CN101152345B - Traditional Chinese medicine preparation for treating female acyesis caused by ovulation obstacle - Google Patents
Traditional Chinese medicine preparation for treating female acyesis caused by ovulation obstacle Download PDFInfo
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Abstract
The present invention pertains to the art of Chinese medicine products and provides a Chinese medicine for treating female barrenness due to the suppression of ovulation, mainly comprising ginseng, hominis placenta, angelica, codonopsis pilosula, wolfberry and epimedium. After being prepared, the combination synergy effect of all the drugs can adjust female endocrine disorders, improve body immunity and luteal function, facilitate follicle formation, eliminate polycystic ovary, prevent more follicles ovulation, optimize the fertilized egg in the innate and avoid the occurrence of abortion and fetal malformation. Compared with a traditional method, the invention treats both symptom and root cause of the disease, improves ovulation rate, pregnancy rate and fertility rate, has no side effect and protects female health.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to a kind of Chinese medicine preparation for the treatment of female acyesis, be specifically related to a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes.
Background technology
The occurrence cause of infertility is a lot, and wherein the infertile patient that causes because of ovulation failure is more, reaches 25-30%, traditional Therapeutic Method mainly adopts the treatment of Western medicine clomiphene, bring out ovulation, ovulation rate is about 50%, but side effect is bigger, causing pregnancy rate only is 30%, easily multiple pregnancy accounts for about 15%, and abortion ratio is up to about 25%, cause easily that also ovarian hyperstimulation syndrome takes place, the infringement women's health.
Summary of the invention
The inventor is in the diagnosis and treatment activity of being engaged in gynaecopathia for a long time, through investigation, find that traditional doctor trained in Western medicine is existing open defect aspect the infertility that causes of treatment ovulation failure, people thirst for this infertility medicine of treatment of determined curative effect, the objective of the invention is to develop a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes, can overcome the existing existing defective of western medicine method preferably.
For realizing task of the present invention, the inventor is through exploring repeatedly, and test improves, the technical scheme of being taked is a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes of design, adopts and is made up of following weight portion medicine: Radix Ginseng 9-25, Placenta Hominis 18-36, Radix Angelicae Sinensis 15-35, the 30-90 of Radix codonopsis pilosulae (Radix Codonopsis), fructus lycii 30-60, Radix Rubiae 15-35, Flos Rosae Chinensis 15-35, Flos Carthami 5-20, Periostracum Cicadae 10-30, Colla cornus cervi 15-45, Herba Epimedii 30-60.
Through preferred, the present invention adopts and is made up of following weight portion medicine: Radix Ginseng 12-20, Placenta Hominis 20-30, Radix Angelicae Sinensis 20-30, the 40-60 of Radix codonopsis pilosulae (Radix Codonopsis), fructus lycii 35-55, Radix Rubiae 20-30, Flos Rosae Chinensis 20-30, Flos Carthami 10-15, Periostracum Cicadae 15-25, Colla cornus cervi 25-35, Herba Epimedii 40-50.
Above-mentioned component and preferred component are that the inventor sums up out through groping repeatedly, all have curative effect preferably in the each component amount ranges.
In order further to improve curative effect, at the difficult state of an illness such as polycystic ovary of some colonies, the inventor through exploring, also adds following weight portion medicine: Radix Dipsaci 30-60, Colla Corii Asini 25-40, Herba Taxilli 20-40 again in above-mentioned prescription.
The inventor reaches clinical experience for many years according to theory of Chinese medical science, think the women because of ovulation failure cause infertile, mainly be because the endocrine disturbance of human body, hypoimmunity, hormonal readiness descends, cause not having follicle, or primordial follicle or polycystic ovary are arranged, the performance menoxenia, amenorrhea, obesity, hirsutism, symptoms such as endometriosis or breast lesion.
The present invention selects the said medicine component for use, and with Radix Ginseng, Placenta Hominis when being classified as monarch drug, is because Radix Ginseng is returned lung spleen heart kidney channel, can promote anabolism, slow down aging; Placenta Hominis GUIXIN lung kidney channel, the kidney-replenishing that fills blood can promote gonadal hormone, regulates immunity; Radix Angelicae Sinensis GUIXIN spleen Liver Channel can strengthen hemopoietic function, regulates immunity.With Radix codonopsis pilosulae (Radix Codonopsis), fructus lycii, Radix Rubiae is ministerial drug, because the spleen lung meridian is returned by Radix codonopsis pilosulae (Radix Codonopsis), can strengthen hemopoietic function, and immunity is regulated, slow down aging in excited uterus; Fructus lycii is returned the Liver and kidney lung meridian, nourishing the liver and kidney, and benefit is smart; Radix Rubiae returns Liver Channel, the energy blood circulation promoting and blood stasis dispelling, and cooling blood for hemostasis is stimulated the menstrual flow, excited uterus, leukocyte increasing, anti-monster.With Flos Rosae Chinensis, Flos Carthami, Herba Epimedii is assistant, because Flos Rosae Chinensis is returned Liver Channel, promoting blood flow to regulate menstruation is transferred smooth QI and blood; Reddening GUIXIN Liver Channel, promoting blood circulation to restore menstrual flow; Herba Epimedii is returned the Liver and kidney warp, kidney-replenishing, and the energy endocrine regulation improves immunity.With Periostracum Cicadae, Colla cornus cervi for making because Periostracum Cicadae returns the lung Liver Channel, the wind spasmolytic of loosing; Colla cornus cervi is returned the Liver and kidney warp, energy YIN nourishing and QI supplementing, promoting generation of vital essence and blood.
Why the present invention also will add Radix Dipsaci, Colla Corii Asini, Herba Taxilli, is because Radix Dipsaci is returned the kidney Liver Channel, invigorating the liver and kidney, and blood circulation regulating ends metrorrhagia, can prevent and treat habitual abortion; Colla Corii Asini is returned lung Liver and kidney warp, and nourishing is nourished blood, arresting bleeding and miscarriage prevention; Herba Taxilli is returned the kidney Liver Channel, invigorating the liver and kidney, and antiabortive unit is used for metrorrhagia, blood leaking in gestation, frequent fetal movement.
The present invention with above-mentioned monarch, minister, help, make and increase medicine and carry out combination and compatibility, each efficacy of drugs produces synergism, can regulate the female incretion function, human body immunity improving power, regulate luteal function, impel follicle to generate and grow, eliminate polycystic ovary, prevent polyovulation, for ovum provides nutrition, improve the ovum effective mass, make germ cell be able to congenital optimization, avoid miscarriage and monster to take place preferably in the period of development, compare with existing method, have and have no side effect, treating both the principal and secondary aspects of a disease meets the remarkable advantage of population and family planning policy.
The specific embodiment
One, Example formulations:
A kind of Example formulations 1 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts and is made by following weight portion medicine: Radix Ginseng 9, Placenta Hominis 18, Radix Angelicae Sinensis 15, Radix codonopsis pilosulae (Radix Codonopsis) 30, fructus lycii 30, Radix Rubiae 15, Flos Rosae Chinensis 15, Flos Carthami 5, Periostracum Cicadae 10, Colla cornus cervi 15, Herba Epimedii 30.
A kind of Example formulations 2 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts and is made by following weight portion medicine: Radix Ginseng 25, Placenta Hominis 36, Radix Angelicae Sinensis 35, Radix codonopsis pilosulae (Radix Codonopsis) 90, fructus lycii 60, Radix Rubiae 35, Flos Rosae Chinensis 35, Flos Carthami 20, Periostracum Cicadae 30, Colla cornus cervi 45, Herba Epimedii 60.
A kind of Example formulations 3 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts and is made by following weight portion medicine: Radix Ginseng 15, Placenta Hominis 25, Radix Angelicae Sinensis 25, Radix codonopsis pilosulae (Radix Codonopsis) 50, fructus lycii 40, Radix Rubiae 25, Flos Rosae Chinensis 25, Flos Carthami 10, Periostracum Cicadae 20, Colla cornus cervi 30, Herba Epimedii 45.
A kind of Example formulations 4 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts and is made by following weight portion medicine: Radix Ginseng 12, Placenta Hominis 20, Radix Angelicae Sinensis 20, Radix codonopsis pilosulae (Radix Codonopsis) 40, fructus lycii 35, Radix Rubiae 20, Flos Rosae Chinensis 20, Flos Carthami 10, Periostracum Cicadae 15, Colla cornus cervi 25, Herba Epimedii 40.
A kind of Example formulations 5 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts and is made by following weight portion medicine: Radix Ginseng 20, Placenta Hominis 30, Radix Angelicae Sinensis 30, Radix codonopsis pilosulae (Radix Codonopsis) 60, fructus lycii 55, Radix Rubiae 30, Flos Rosae Chinensis 30, Flos Carthami 15, Periostracum Cicadae 25, Colla cornus cervi 35, Herba Epimedii 50.
A kind of Example formulations 6 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts to add Radix Dipsaci 30, Colla Corii Asini 25, Herba Taxilli 20 in Example formulations 1 or 4.
A kind of Example formulations 7 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts to add Radix Dipsaci 60, Colla Corii Asini 40, Herba Taxilli 40 in Example formulations 2 or 5.
A kind of Example formulations 8 for the treatment of the Chinese medicine preparation of female acyesis of the present invention adopts to add Radix Dipsaci 40, Colla Corii Asini 35, Herba Taxilli 30 in Example formulations 3.
Above-mentioned each example formulations of the present invention all is the prescription that the inventor finds out in clinical trial, can both play curative effect preferably to the patient of the different state of an illness.
The present invention takes by weighing by above-mentioned prescription dosage, through mixing, pulverizes, and makes concentrated solution or pill, granule according to conventional preparation method.
Two, the envelop of function of Chinese medicine preparation of the present invention: the infertility that treatment women ovulation failure causes.
Three, usage and dosage of the present invention: oral morning every day, evening each 1 time, each 20-30 gram pours yellow wine, and 2 weeks were a course of treatment, minimum taking 2 courses of treatment, the longest taking 6 courses of treatment.
Four, clinic trial of the present invention is observed: accept out-patient's 100 examples for medical treatment, the patient is divided into two groups voluntarily at random, matched group 20 examples adopt conventional Western medicine method treatment, 80 examples are organized in treatment, minimum 21 years old of age wherein, maximum 48 years old, the course of disease the shortest half a year, the longest 15 years, the course of treatment is the shortest 2 months, and is the longest 3 years.
Diagnostic criteria:
1, detects endocrine, hormonal readiness through chemical examination, low person;
2, ultrasound diagnosis result has primordial follicle, or does not have follicle, or the polycystic ovary person.
Efficacy assessment standard:
1, cures, for becoming ovum, pregnancy, fertility;
2, effective, be the one-tenth ovum, or not conceived, or the miscarriage of conceived back;
3, invalid, for symptom does not have change, or the ovum disunion, not broken.
Comparison sheet as a result:
As can be seen from the above table, treatment group curative effect obviously is better than matched group, total effective rate 88.8%, and cure rate 72.5% is higher than 55%, 30% of matched group respectively.
Case 1, Zhang, the woman, 35 years old, Bin He road, the Nanyang worker of company, first visit in April, 2005, face is told to live together after marriage and was not practised contraception and unpregnancy in 8 years, and bridegroom's or husband's side semen efamination is normal.Menstruation 6/40 day, menstruation last time on April 5th, 2003, color is dark, and amount is few, usually soreness of the waist and knees, coldness of the body with chills, property paddy is indifferent, and pale tongue is fat, white and thin fur, deep-thready pulse, BBT are single-phase, and the hydrotubation test is shown: the bilateral fallopian tube is unobstructed, Western medicine diagnose: the constitutional ovulatory dysfunction is infertile; Differential diagnosis in tcm: kidney yang deficiency syndrome is infertile.By the menstruation cycle therapy, suitable warming the kidney to invigorate YANG, benefiting QI and nourishing blood, oral medicine of the present invention, every day secondary, each 25 the gram, serve on 15, continue 6 cycles of treatment, BBT presents typical two-phase, advise its clothes that continue after clean, advise patient front and back onset of ovulation having sexual intercourse thing, the patient is when on October 26th, 2005 further consultation, private prosecution menolipsis 40 days, BBT is high 21 days mutually, stringy pulse and sliding, the pregnancy tests positive, the prompting patient is gestation.
Case 2, Yuan so-and-so, the woman, 28 years old, architectural engineering worker of office in Zhengzhou City's was in first visit on May 14 in 2006, private prosecution was married 5 years, and the man and wife lives together, and contraception is not and infertile, and its husband's seminal fluid routine examination is normal, the patient once did the hydrotubation test in the outer court, show normally diagnostic curettage once before the menstruation, be reported as proliferative phase of endometrium, it is single-phase that BBT is, menstruation 3/24 day, and amount is few, color is red, soreness of the waist and knees usually, dizziness and tinnitus, feverish sensation in the palms and soles, the body of the tongue point is red, yellow and thin fur, thready and rapid pulse, Western medicine diagnose: the constitutional ovulatory dysfunction is infertile.Differential diagnosis in tcm: kidney yang deficiency syndrome is infertile, controls suitable kidney-yang nourishing by the menstruation cycle therapy.Oral medicine secondary every day of the present invention, each 25 grams serve on 15, continue 3 all after dates of treatment, BBT is typical two-phase, and surplus disease disappears, and is conscious good, when JIUYUE in 2006 further consultation on the 15th, BBT has continued high 22 days mutually, the pregnancy tests positive, and the prompting patient is conceived.
Claims (10)
1. Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes, it is characterized in that forming: Radix Ginseng 9-25, Placenta Hominis 18-36, Radix Angelicae Sinensis 15-35 by following weight portion medicine, the 30-90 of Radix codonopsis pilosulae (Radix Codonopsis), fructus lycii 30-60, Radix Rubiae 15-35, Flos Rosae Chinensis 15-35, Flos Carthami 5-20, Periostracum Cicadae 10-30, Colla cornus cervi 15-45, Herba Epimedii 30-60.
2. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 1, it is characterized in that forming: Radix Ginseng 12-20, Placenta Hominis 20-30, Radix Angelicae Sinensis 20-30 by following preferred weight part medicine, the 40-60 of Radix codonopsis pilosulae (Radix Codonopsis), fructus lycii 35-55, Radix Rubiae 20-30, Flos Rosae Chinensis 20-30, Flos Carthami 10-15, Periostracum Cicadae 15-25, Colla cornus cervi 25-35, Herba Epimedii 40-50.
3. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 1 is characterized in that being made up of following weight portion medicine: Radix Ginseng 9, Placenta Hominis 18, Radix Angelicae Sinensis 15, Radix codonopsis pilosulae (Radix Codonopsis) 30, fructus lycii 30, Radix Rubiae 15, Flos Rosae Chinensis 15, Flos Carthami 5, Periostracum Cicadae 10, Colla cornus cervi 15, Herba Epimedii 30.
4. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 1 is characterized in that being made up of following weight portion medicine: Radix Ginseng 25, Placenta Hominis 36, Radix Angelicae Sinensis 35, Radix codonopsis pilosulae (Radix Codonopsis) 90, fructus lycii 60, Radix Rubiae 35, Flos Rosae Chinensis 35, Flos Carthami 20, Periostracum Cicadae 30, Colla cornus cervi 45, Herba Epimedii 60.
5. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 1, it is characterized in that forming: Radix Ginseng 15, Placenta Hominis 25, Radix Angelicae Sinensis 25 by following weight portion medicine, Radix codonopsis pilosulae (Radix Codonopsis) 50, fructus lycii 40, madder can the grass 25, Flos Rosae Chinensis 25, Flos Carthami 10, Periostracum Cicadae 20, Colla cornus cervi 30, Herba Epimedii 45.
6. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 2 is characterized in that being made up of following weight portion medicine: Radix Ginseng 12, Placenta Hominis 20, Radix Angelicae Sinensis 20, Radix codonopsis pilosulae (Radix Codonopsis) 40, fructus lycii 35, Radix Rubiae 20, Flos Rosae Chinensis 20, Flos Carthami 10, Periostracum Cicadae 15, Colla cornus cervi 25, Herba Epimedii 40.
7. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 2 is characterized in that being made up of following weight portion medicine: Radix Ginseng 20, Placenta Hominis 30, Radix Angelicae Sinensis 30, Radix codonopsis pilosulae (Radix Codonopsis) 60, fructus lycii 55, Radix Rubiae 30, Flos Rosae Chinensis 30, Flos Carthami 15, Periostracum Cicadae 25, Colla cornus cervi 35, Herba Epimedii 50.
8. a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes as claimed in claim 1 or 2 is characterized in that also adding following weight portion medicine: Radix Dipsaci 30-60, Colla Corii Asini 25-40, Herba Taxilli 20-40.
9. as claim 3 or 6 described a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes, it is characterized in that also adding following weight portion medicine: Radix Dipsaci 30, Colla Corii Asini 25, Herba Taxilli 20.
10. as claim 4 or 7 described a kind of Chinese medicine preparation for the treatment of the female acyesis that ovulation failure causes, it is characterized in that also adding following weight portion medicine: Radix Dipsaci 60, Colla Corii Asini 40, Herba Taxilli 40.
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| CN104784587A (en) * | 2015-05-08 | 2015-07-22 | 宋佳伦 | Traditional Chinese medicine composition for treating endocrine dyscrasia type infertility and preparation method thereof |
| CN104888175A (en) * | 2015-06-25 | 2015-09-09 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treatment of Yang-deficiency and cold-blood type diminished ovarian reserve function |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356123A (en) * | 2001-08-16 | 2002-07-03 | 赵西铭 | Medicine for treating female acyesis |
| CN1461652A (en) * | 2002-05-27 | 2003-12-17 | 李敬纯 | Pure traditional Chinese medicine prepn. for treating female sterility, and its prepn. method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356123A (en) * | 2001-08-16 | 2002-07-03 | 赵西铭 | Medicine for treating female acyesis |
| CN1461652A (en) * | 2002-05-27 | 2003-12-17 | 李敬纯 | Pure traditional Chinese medicine prepn. for treating female sterility, and its prepn. method |
Non-Patent Citations (2)
| Title |
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| 许润三.中医治疗排卵障碍性不孕症.药物与人.2007,68-69. * |
| 邓萍.中医及中西医结合治疗排卵障碍性不孕的研究进展.现代中西医结合杂志14 24.2005,14(24),3310-3312. * |
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