CN104888175A - Traditional Chinese medicine for treatment of Yang-deficiency and cold-blood type diminished ovarian reserve function - Google Patents

Abstract

The invention belongs to the technical field of medication and particularly relates to traditional Chinese medicine for treatment of Yang-deficiency and cold-blood type diminished ovarian reserve function. The traditional Chinese medicine is prepared from traditional Chinese medicine raw materials comprising, by weight, 8-16 parts of herba epimedii, 5-13 parts of curculigo orchioides, 2-4 parts of human placenta, 8-16 parts of eucommia ulmoides, 8-16 parts of teasel roots, 8-16 parts of ginseng, 8-16 parts of codonopsis pilosula, 8-16 parts of angelia sinensis, 8-16 parts of colla corii asini, 8-16 parts of aconitum carmichaelii, 8-16 parts of dried ginger, 4-8 parts of cortex cinnamomi, 5-13 parts of clove, 8-16 parts of safflower carthamus, 8-16 parts of roots of bidentate achyranthes, 4-8 parts of rosa chinensis and 4-8 parts of liquorice. By the application of the traditional Chinese medicine for treatment of the Yang-deficiency and cold-blood type diminished ovarian reserve function, sex hormone levels can be remarkably removed, presentation of ovarian granulose cell of inhibin B protein and anti-mullerian hormone are up-regulated, the count of antrum ovarian follicle is increased, ovarian volume is enlarged, ovarian blood supply in improved, ovarian reserve function is improved, clinical symptoms are improved, and clinical curative effect is distinct.

Description

A kind of Chinese medicine for the treatment of yang deficiency blood-cold type diminished ovarian reserve function

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of yang deficiency blood-cold type diminished ovarian reserve function.

Background technology

Ovary reserve (Ovairan Reservation, OR) refers to the ability of ovarian cortex district ovarian follicular growth, growth, formation fertilizability follicle.Therefore the decline of reproductive function shows that the quality that the ovulum blast cell in cortical areas stores and quantity decline, and this is also the basic intension of diminished ovarian reserve function (Decreasing Ovarian Reservation, DOR).The DOR clinical manifestation initial stage there is no special, i.e. the shortening in the clinical manifestation of the earliest period of ovarian senescence mainly menstrual period, then occurs the menopause transition performances such as irregular, menostaxis in menstrual period.Major part patient early symptom is slight, easily ignores, and manyly when symptom is obvious has developed into premature ovarian failure (Premature Ovarian Failure, POF), thus bad old practices die hard.Domestic and international research display, approximately needs 1 ~ 6 year from DOR to ovarian function failure amenorrhea.So, earlier evaluations DOR, and treating in time, significant to prevention amenorrhea, infertile, POF etc.

The multiplex hormone replacement therapy of DOR doctor trained in Western medicine, and hormone can increase the disease incidence danger such as endometrial hyperplasia, carcinoma of endometrium, breast carcinoma, apoplexy, and contraindication is more, therefore finds Therapeutic Method safely and effectively particularly important.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of yang deficiency blood-cold type diminished ovarian reserve function is provided, this Chinese medicine can obvious improvement hormonal readiness, raise the expression of gonad granulocyte inhibin B albumen, anti-gyneduct hormone, increase Antral follicles, increase Ovarian Volume, improve the confession of ovary blood, improve Ovary reserve, improve clinical symptoms, clinical efficacy is remarkable.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 8-16 part, Rhizoma Curculiginis 5-13 part, Placenta Hominis 2-4 part, Cortex Eucommiae 8-16 part, Radix Dipsaci 8-16 part, Radix Ginseng 8-16 part, Radix Codonopsis 8-16 part, Radix Angelicae Sinensis 8-16 part, Colla Corii Asini 8-16 part, Radix Aconiti Lateralis Preparata 8-16 part, Rhizoma Zingiberis 8-16 part, Cortex Cinnamomi 4-8 part, Flos Caryophylli 5-13 part, Flos Carthami 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Flos Rosae Chinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment yang deficiency blood-cold type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 10-14 part, Rhizoma Curculiginis 7-11 part, Placenta Hominis 2.5-3.5 part, Cortex Eucommiae 10-14 part, Radix Dipsaci 10-14 part, Radix Ginseng 10-14 part, Radix Codonopsis 10-14 part, Radix Angelicae Sinensis 10-14 part, Colla Corii Asini 10-14 part, Radix Aconiti Lateralis Preparata 10-14 part, Rhizoma Zingiberis 10-14 part, Cortex Cinnamomi 5-7 part, Flos Caryophylli 7-11 part, Flos Carthami 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Flos Rosae Chinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment yang deficiency blood-cold type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 12 parts, Rhizoma Curculiginis 9 parts, Placenta Hominis 3 parts, the Cortex Eucommiae 12 parts, Radix Dipsaci 12 parts, Radix Ginseng 12 parts, Radix Codonopsis 12 parts, Radix Angelicae Sinensis 12 parts, 12 parts, Colla Corii Asini, Radix Aconiti Lateralis Preparata 12 parts, Rhizoma Zingiberis 12 parts, Cortex Cinnamomi 6 parts, Flos Caryophylli 9 parts, 12 parts, Flos Carthami, Radix Achyranthis Bidentatae 12 parts, Flos Rosae Chinensis 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of delayed menstrual cycle that yang deficiency blood-cold type diminished ovarian reserve function causes, very few.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

Yang deficiency blood-cold type is the clinical common pattern of syndrome of DOR.The pathogeny of DOR is main relevant with the pathological changes of kidney and blood.In kidney, yang-energy can the metabolic activity of warm, exciting human, is the power that Follicular growth and ovum are discharged.YANG QI deficiency, yin-cold excess, internal organs deficiency and coldness, insufficiency of generating and transforming QI and blood, deficiency of vital energy insufficiency of blood, punching is appointed can not lead to Sheng on time, and sea of blood spill-over postpones, or cold blood stasis, therefore menstruation is postponed and arrives, and amount is few, and color is light, and matter is rare; Deficiency and coldness in born of the same parents, vessels of the uterus loses in replenishing vital QI with drugs of warm nature, therefore has a dull ache through row lower abdomen, likes hot pain relieved by pressing; Yang deficiency deficiency of kidney-QI, outer mansion is lost and is supported, therefore the soreness of waist is unable; Yang-energy is cloth not, therefore face is in vain photochromic; Deficiency-cold in the urinary bladder, loses in warm, therefore clear urine in large amounts.Light red tongue, thin fur, deep-slow pulse is unable, is levying of deficiency and coldness.Therefore need warming the meridian and reinforcing YANG be adopted, the delayed menstrual cycle, very few of yang deficiency blood-cold type diminished ovarian reserve function is treated in nourishing blood for regulating menstruation ruling by law.

Prescription is as follows:

Monarch drug: Herba Epimedii, Rhizoma Curculiginis, Placenta Hominis, the Cortex Eucommiae, Radix Dipsaci merit, with warming the kidney to invigorate YANG, adjust punching to appoint; Be monarch drug altogether.Yang-energy is sufficient, and YIN-cold is from going.

Ministerial drug: Radix Ginseng, Radix Codonopsis, Radix Angelicae Sinensis, Colla Corii Asini merit are with benefiting QI and nourishing blood; QI and blood is filled, and on time logical Sheng is appointed in punching, and menstruation on time.

Adjuvant drug: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Cortex Cinnamomi, Flos Caryophylli merit are with dispelling cold by warming the meridian, and vessels of the uterus must in replenishing vital QI with drugs of warm nature, and sympotoms caused by cold factors must be removed.Flos Carthami, Radix Achyranthis Bidentatae, Flos Rosae Chinensis merit are with promoting blood flow to regulate menstruation, and wherein Flos Rosae Chinensis is good at dispersing the stagnated live-QI to relieve the stagnation of QI, adjust smooth QI and blood, simultaneously availablely control the stagnation of liver-QI symptoms such as the irritable that with the passing of time female irregular menstruation cause.

Make medicine: Radix Glycyrrhizae for making, coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, plays warming the meridian and reinforcing YANG altogether, the effect of nourishing blood for regulating menstruation, the delayed menstrual cycle for the treatment of yang deficiency blood-cold type diminished ovarian reserve function, very few, make its YIN and YANG in a relative equilibrium, essence and blood all prosperous, QI and blood is logical to be adjusted, then menstruation self-regulated, can obvious improvement hormonal readiness, raises the expression of gonad granulocyte inhibin B albumen, anti-gyneduct hormone, increase Antral follicles, increase Ovarian Volume, improve the confession of ovary blood, improve Ovary reserve, improve clinical symptoms, clinical efficacy is remarkable, is worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Herba Epimedii 12g, Rhizoma Curculiginis 9g, Placenta Hominis 3g, Cortex Eucommiae 12g, Radix Dipsaci 12g, Radix Ginseng 12g, Radix Codonopsis, 12g, Radix Angelicae Sinensis 12g, Colla Corii Asini 12g, Radix Aconiti Lateralis Preparata 12g, Rhizoma Zingiberis 12g, Cortex Cinnamomi 6g, Flos Caryophylli 9g, Flos Carthami 12g, Radix Achyranthis Bidentatae 12g, Flos Rosae Chinensis 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Herba Epimedii 10g, Rhizoma Curculiginis 11g, Placenta Hominis 2.5g, Cortex Eucommiae 10g, Radix Dipsaci 14g, Radix Ginseng 10g, Radix Codonopsis 14g, Radix Angelicae Sinensis 10g, Colla Corii Asini 14g, Radix Aconiti Lateralis Preparata 10g, Rhizoma Zingiberis 14g, Cortex Cinnamomi 5g, Flos Caryophylli 7g, Flos Carthami 14g, Radix Achyranthis Bidentatae 10g, Flos Rosae Chinensis 7g, Radix Glycyrrhizae 7g.

Embodiment 3

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Herba Epimedii 14g, Rhizoma Curculiginis 7g, Placenta Hominis 3.5g, Cortex Eucommiae 14g, Radix Dipsaci 10g, Radix Ginseng 14g, Radix Codonopsis 10g, Radix Angelicae Sinensis 14g, Colla Corii Asini 10g, Radix Aconiti Lateralis Preparata 14g, Rhizoma Zingiberis 10g, Cortex Cinnamomi 7g, Flos Caryophylli 7g, Flos Carthami 10g, Radix Achyranthis Bidentatae 14g, Flos Rosae Chinensis 5g, Radix Glycyrrhizae 5g.

Embodiment 4

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Herba Epimedii 8g, Rhizoma Curculiginis 13g, Placenta Hominis 2g, Cortex Eucommiae 8g, Radix Dipsaci 16g, Radix Ginseng 8g, Radix Codonopsis 16g, Radix Angelicae Sinensis 8g, Colla Corii Asini 16g, Radix Aconiti Lateralis Preparata 8g, Rhizoma Zingiberis 16g, Cortex Cinnamomi 4g, Flos Caryophylli 5g, Flos Carthami 16g, Radix Achyranthis Bidentatae 8g, Flos Rosae Chinensis 8g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Herba Epimedii 16g, Rhizoma Curculiginis 5g, Placenta Hominis 4g, Cortex Eucommiae 16g, Radix Dipsaci 8g, Radix Ginseng 16g, Radix Codonopsis 8g, Radix Angelicae Sinensis 16g, Colla Corii Asini 8g, Radix Aconiti Lateralis Preparata 16g, Rhizoma Zingiberis 8g, Cortex Cinnamomi 8g, Flos Caryophylli 13g, Flos Carthami 8g, Radix Achyranthis Bidentatae 16g, Flos Rosae Chinensis 4g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to treatment yang deficiency blood-cold type diminished ovarian reserve function Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose the delayed menstrual cycle of yang deficiency blood-cold type diminished ovarian reserve function, very few patient 200 example.

1.1.1 diagnostic criteria

Western medicine diagnose standard:

Draft with reference to " practical gynecologic endocrinology (the 2nd edition) ", " obstetrics and gynecology (the 7th edition) " and " obstetrical and gynecological disease Diagnosis and differential diaggnosis (the 2nd edition) ".(1) patient has normal menstruation or childbearing history, obviously gradually occurs infrequent menstruation, simultaneously can with irritable, hectic fever sweating, the class such as soreness of the waist and knees, hyposexuality perimenopausal symptom.(2) 10mIU/mL< follicle-stimulating growth hormone (FSH) < 40mIU/mL; Or FSH/ interstitialcellstimulating hormone (ICSH) (LH) > 3.6; Above-mentionedly meet wherein one.

Tcm diagnosis standard

(1) traditional Chinese medical science differential diagnosis of diseases standard

Draft with reference to the diagnostic criteria of menoxenia in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002.

Delayed menstrual cycle: wrong latter more than 7 days of menstrual cycle, even 3 ~ 5 months a line, menstrual blood volume is normal, needs to occur more than two menstrual cycle continuously.

Hypomenorrhea: refer to that menstrual cycle is normal, menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, there are more than two menstrual cycle continuously.It is generally acknowledged Hypomenorrhea in 20ml be hypomenorrhea.

(2) Standards of Chinese Medical Syndrome Differentiation

Draft with reference to the CM syndrome differentiation criterion of nephrasthenia syndrome, syndrome of blood stasis in menoxenia in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002.

Main symptom: 1. menstruation is delayed; 2. Hypomenorrhea; 3. the rare color of the light matter of color secretly has block.

Secondary disease: 1. the soreness of waist is unable; Lumbosacral aching pain is lower abdomen dull pain 2., likes hot pain relieved by pressing; Dizziness and tinnitus is clear urine in large amounts 3.; Hectic fever sweating is the white hyposexuality of the complexion corner of the eyes 4..

Tongue arteries and veins: light red tongue, tongue is white, and the unable light red tongue of deep-slow pulse or purple dark side have ecchymosis, deep-thready pulse or heavy.

1., 2. primary symptom at least possesses one, and possesses 3. simultaneously, secondary disease 1. ~ 4. in one, in conjunction with tongue arteries and veins can dialectical for blood stasis due to renal deficiency demonstrate,prove.

1.1.2 include case standard in

1. age >20 year and <40 year.

2. primary disease Western medicine diagnose standard and tcm diagnosis standard person is met.

3. do not merge and use other medicines therapist.

4. urine pregnancy test is negative.

5. patient willingness participates in this research and actively can coordinate further consultation, completes clinical observers.

1.1.3 Excluded cases standard

1. age >40 year or <20 year.

2. hormone medicine therapist is applied in 3 months.

3. genitals organic disease person is associated with.

4. the severe primary disease patients such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are merged.

5. the premature ovarian failure that causes of bilateral ovaries or Unilateral oophorectomy.

6. psychotic.

7. not by regulation medication, curative effect cannot be judged, or the not congruent judgement person that affects the treatment of data.

8. polycystic ovary syndrome is got rid of.

9. previously menorrhagia is got rid of

The case standard 1.1.4 come off

1. the bad person of compliance.

2. occur that adverse events should not proceed this clinical trial person.

3. experimenter exits voluntarily.

1.2 method

1.2.1 Therapeutic Method

Adopt the Chinese medicine of the treatment yang deficiency blood-cold type diminished ovarian reserve function of the embodiment of the present invention 1, prescription: Herba Epimedii 12g, Rhizoma Curculiginis 9g, Placenta Hominis 3g, Cortex Eucommiae 12g, Radix Dipsaci 12g, Radix Ginseng 12g, Radix Codonopsis, 12g, Radix Angelicae Sinensis 12g, Colla Corii Asini 12g, Radix Aconiti Lateralis Preparata 12g, Rhizoma Zingiberis 12g, Cortex Cinnamomi 6g, Flos Caryophylli 9g, Flos Carthami 12g, Radix Achyranthis Bidentatae 12g, Flos Rosae Chinensis 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, every day potion, sooner or later sub-service.Menstruation starts every day one pair on the 5th day, and serveing on 14 days is a course for the treatment of.Be used in conjunction two menstrual cycle.

1.2.2 observation index

Lab index: serum FSH, LH, FSH/LH, estradiol (E2) level are with chemiluminescence determination.Inhibin B(INHB), AMH (AMH) adopts elisa (ELISA) detection method.(menstruation 2nd ~ 3 days)

Vagina supersonic inspection: observe basic Antral follicles (Antral Follicle Count, AFC) peak systolic velocity (the Peak Systolic Velocity obtained under blood flow parameter chromatic colour Doppler (Color Doppler) condition that (follicle of diameter 2 ~ 10mm), flat Ovarian Volume, ovarian stromal blood flow are used, PSV), pulsatility index (Pulsatility In-Dex, PI), drag index (Resistance Index, RI).

TCM syndrome integration: instruct with reference to the scalar quantization index of menoxenia deficiency of YANG of middle-JIAO blood-cold type in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002 and draft.

1.2.3 tcm syndrome curative effect determinate standard

Relevant criterion with reference to " new Chinese medicine guideline of clinical investigations " is drafted.Computing formula (nimodipine method): integration × 100% before therapeutic index (n)=(before treatment the rear integration of integration-treatment)/treatment.

1. cure: menstruation recovers normal through amount, cycle; Clinical symptom disappearance or substantially disappear, maintains more than 3 menstrual cycle.N >=95%; 2. effective: menstruation is close normal through amount, cycle; Clinical symptoms is obviously improved, and continues more than 3 menstrual cycle.95% > n >=70%; 3. effective: menstruation increases to some extent through amount, and delayed menstrual cycle person shortens the postponed menstruation time to some extent, but menstrual cycle is abnormal; Clinical symptoms all take a favorable turn but fails lasting 3 menstrual cycle.70% > n >=30%; 4. invalid: menstruation through amount, the cycle is without improvement; Clinical symptoms is all not improved, even increase the weight of.n＜30％

1.2.4 regulating menstruation observation of curative effect

Menstrual blood loss (Menstrual Blood, MBL) measures: MBL is assessed in application menstrual blood loss figure (Pictprial Blood Loss Assessment Chart, PBAC).After each sanitary towel of menstruation each time menstrual period before and after patient treatment finishes using, all put into plastic bag voluntarily by patient and deposit, MBL press to PBAC method is marked, record simultaneously.Again by reclassifying in person, marking, record, adjust after the sanitary towel left in plastic bag is collected.

Degree of staining with blood according to PBAC Mei Zhang sanitary towel is divided into:

Slight: to stain 1/3 of area≤whole sanitary towel area with blood, comment 1 point;

Moderate: stain that area accounts for whole sanitary towel area with blood 1/3 ~ 3/5, comments 5 points;

Severe: staining area with blood is whole sanitary towel substantially, comments 20 points.

The clot size scoring of losing:

Lose clot <1 unit coin, be little clot, comment 1 point;

Lose clot >=1 yuan coin, be large clot, comment 5 points;

Every patient per MBL Integral Transformation of passing through becomes TCM symptom score standard:

MBL integration≤10 point, symptom integral meter 12 points;

10 points of <MBL integration≤15 point, symptom integral meter 6 points;

15 points of <MBL integration≤20 point, symptom integral meter 4 points;

20 points of <MBL integration≤25 point, symptom integral meter 2 points;

MBL integration ﹥ 25 points, symptom integral meter 0 point.

Note: the scoring of PBAC method with the corresponding relation of MBL is: 1ml blood can comment to obtain 1.25 points, and namely the size of score value is 1.25 times of blood volume.Then 100 points of persons, blood volume is 80ml; Blood volume is 20ml person, can comment to obtain 25 points.

1.2.5 regulating menstruation efficacy assessment standard

1. cure: recover normal (quite through amount about 30 ~ 80 milliliters) through amount after treatment, drug withdrawal 3 menstrual cycle do not recur.

2. effective: after treatment through amount comparatively treatment before increase and more than.

3. effective: to improve before amount comparatively treatment after treatment.

4. invalid: unchanged through measuring after treatment.

1.2.6 statistical method

Adopt SPSS18.0 version statistics software to process, measurement data represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 between group.

2. result

TCM syndrome integration curative effect before and after 2.1 treatments

Treat rear and drug withdrawal TCM syndrome integration obviously reduction before all comparatively treating after three months, difference has statistical significance (P<0.05); After treatment and drug withdrawal comparing difference not statistically significant (P>0.05) after three months.

Front and back TCM syndrome integration curative effect treated by table 1

Number of cases	Before treatment	After treatment	Drug withdrawal is after three months
				200	23.32±2.89	7.31±1.04	7.67±1.02

200 routine patient's TCM syndrome curative effects: cure: 68 examples (34.0%), effective 110 examples (55.0%), effective 20 examples (10.0%), invalid 2 examples (1.0%), cure rate 34.0%, total obvious effective rate 89.0%, total effective rate 99.0%.

2.2 regulating menstruation curative effects

200 routine patient's regulating menstruation curative effects: cure 74 examples (37.0%), effective 96 examples (48.0%), effective 26 examples (13.0%), invalid 4 examples (2.0%), cure rate 37.0%, total obvious effective rate 85.0%, total effective rate 98.0%.

Lab index change before and after 2.3 treatments

After treatment, plasma FSH, LH, FSH/LH, E2, INHB, AMH level are obviously improved before all comparatively treating, and difference has statistical significance (P<0.05).The results are shown in Table 2.

Front and back lab index change treated by table 2

FSH(mIU/ml)

LH(mIU/ml)

FSH/LH

E2(mIU/ml)

INHB(mIU/ml)

AMH(mIU/ml)

Before treatment

19.13±3.54

11.33±2.56

2.74±1.02

23.36±5.26

78.23±13.43

3.01±1.14

After treatment

5.23±1.67

3.22±1.16

1.01±0.72

48.34±8.46

146.45±21.46

6.58±1.14

The observation that before and after 2.4 treatments, female B is super

After treatment, bilateral basis Antral follicles, Ovarian Volume, ovary PSV, ovary PI, ovary RI obviously improve before all comparatively treating, and difference has statistical significance (P<0.05).The results are shown in Table 3.

Table 3 is treated front and back female B and is surpassed results change before treating

Left side Antral follicles

Right side Antral follicles

Left ovary volume

Right ovary volume

Left ovary PSV

Right ovary PSV

Left ovary PI

Right ovary PI

Left ovary RI

Right ovary RI

Before treatment

2.57±1.02

2.45±1.02

4.14±1.32

4.18±1.29

9.12±3.56

9.16±3.84

1.89±0.54

1.96±0.35

0.85±0.15

0.89±0.17

After treatment

7.46±2.56

7.45±2.43

7.67±2.24

7.58±2.24

16.67±4.34

17.23±4.78

1.02±0.43

1.01±0.43

0.26±0.04

0.24±0.03

Claims (3)

1. treat a Chinese medicine for yang deficiency blood-cold type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 8-16 part, Rhizoma Curculiginis 5-13 part, Placenta Hominis 2-4 part, Cortex Eucommiae 8-16 part, Radix Dipsaci 8-16 part, Radix Ginseng 8-16 part, Radix Codonopsis 8-16 part, Radix Angelicae Sinensis 8-16 part, Colla Corii Asini 8-16 part, Radix Aconiti Lateralis Preparata 8-16 part, Rhizoma Zingiberis 8-16 part, Cortex Cinnamomi 4-8 part, Flos Caryophylli 5-13 part, Flos Carthami 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Flos Rosae Chinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of yang deficiency blood-cold type diminished ovarian reserve function according to claim 1, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 10-14 part, Rhizoma Curculiginis 7-11 part, Placenta Hominis 2.5-3.5 part, Cortex Eucommiae 10-14 part, Radix Dipsaci 10-14 part, Radix Ginseng 10-14 part, Radix Codonopsis 10-14 part, Radix Angelicae Sinensis 10-14 part, Colla Corii Asini 10-14 part, Radix Aconiti Lateralis Preparata 10-14 part, Rhizoma Zingiberis 10-14 part, Cortex Cinnamomi 5-7 part, Flos Caryophylli 7-11 part, Flos Carthami 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Flos Rosae Chinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of treatment yang deficiency blood-cold type diminished ovarian reserve function according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

Herba Epimedii 12 parts, Rhizoma Curculiginis 9 parts, Placenta Hominis 3 parts, the Cortex Eucommiae 12 parts, Radix Dipsaci 12 parts, Radix Ginseng 12 parts, Radix Codonopsis 12 parts, Radix Angelicae Sinensis 12 parts, 12 parts, Colla Corii Asini, Radix Aconiti Lateralis Preparata 12 parts, Rhizoma Zingiberis 12 parts, Cortex Cinnamomi 6 parts, Flos Caryophylli 9 parts, 12 parts, Flos Carthami, Radix Achyranthis Bidentatae 12 parts, Flos Rosae Chinensis 6 parts, 6 parts, Radix Glycyrrhizae.