CN110960610A - Traditional Chinese medicine composition for preventing and treating qi deficiency type retained fetal membranes of dairy cows and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating qi deficiency type retained fetal membranes of dairy cows and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating qi deficiency type retained fetal membranes of dairy cows, which is prepared from the following raw material medicines in parts by weight: 60-80 parts of motherwort, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus membranaceus, 30-40 parts of rhodiola rosea, 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 45-65 parts of angelica sinensis, 30-50 parts of ligusticum wallichii, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root and 15-20 parts of rose; and provides a preparation method and application thereof. The traditional Chinese medicine composition can effectively promote the discharge of placenta, reduce the incidence rate of metritis, recover quickly after delivery, improve the reproductive performance of tested cows, solve the problems of drug residues in dairy products caused by clinical treatment drug deficiency and hormone therapy and the like, and meet the medication requirement of green and healthy breeding in the modern dairy industry.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows and a preparation method thereof.
Background
Retention of placenta means that the placenta cannot be discharged in the physiological time limit of the third stage of labor after the female animal delivers the fetus, and in dairy cows, the retention generally means more than 12 hours after delivery. The incidence rate of retained afterbirth in normal calving herd is generally 5% -10%, while the incidence rate of abnormal parturition (such as caesarean section, dystocia, abortion, premature delivery and the like) and herd infected with cloth diseases can reach 20% -50% or even higher. The retention of placenta can obviously increase the risk of suffering from bovine metritis, lead to delayed oestrus, increased mating times, prolonged nonpregnant period and the like of the dairy cattle, seriously affect the postpartum reproductive performance of the dairy cattle, even cause infertility and become a main reason for premature elimination of the dairy cattle.
The traditional veterinary medicine has rich syndrome experience in the aspect of preventing and treating retention of placenta of livestock, has remarkable clinical treatment advantages, and particularly has exact clinical treatment effect in the aspects of promoting retained placenta to be discharged, reducing the risk of secondary infection metritis and improving the breeding performance of the affected cattle. The Chinese patent application 2012103900455 discloses a traditional Chinese veterinary medicine for treating retained afterbirth of dairy cows, which is prepared from 10-20 parts of motherwort, 5-20 parts of dandelion, 5-15 parts of angelica sinensis, 6-9 parts of epimedium, 5-9 parts of ligusticum wallichii, 5-7 parts of bighead atractylodes rhizome, 4-8 parts of codonopsis pilosula, 4-8 parts of astragalus membranaceus, 4-8 parts of hawthorn, 4-7 parts of semen cuscutae, 3-8 parts of bunge corydalis herb, 3-5 parts of rhizoma cyperi, 2-5 parts of immature bitter orange, 2-4 parts of peach kernel, 2-4 parts of eucommia bark, 2-3 parts of safflower, 1-3 parts of honeysuckle and 1-2 parts of honey-fried licorice root, and one or more of dried orange peel, pinellia tuber, trogopterus dung, mangnolia officinalis, prepared rehmannia rhizome, radix. The Chinese patent application 2014105385369 discloses a pharmaceutical composition for treating retained afterbirth disease of dairy cows, which is prepared from 10-30 parts of astragalus membranaceus, 5-30 parts of motherwort, 5-20 parts of cyperus rotundus, 4-30 parts of ligusticum wallichii, 10-40 parts of angelica sinensis, 3-10 parts of trichosanthes kirilowii maxim, 5-10 parts of pericarpium citri reticulatae, 5-30 parts of salvia miltiorrhiza, 2-20 parts of peach kernels, 0.05-1 part of sodium selenite and 0.5-05 part of vitamin E. Chinese patent application 201410608466X discloses a Chinese medicinal oral liquid for treating retained afterbirth of milk cow, which is prepared from semen plantaginis (parched with wine) 20-30 parts, herba Leonuri 20-30 parts, radix Codonopsis 10-20 parts, radix Glycyrrhizae Preparata 10-20 parts, radix Angelicae sinensis 1-10 parts, Carthami flos 1-10 parts and rhizoma Ligustici Chuanxiong 1-10 parts. The traditional Chinese veterinary medicine products protected by the patents do not determine the category of the disease, and the diagnosis and treatment by differentiation are the essence of traditional Chinese veterinary medicine science, and the disease of the cow placenta is different from deficiency and excess.
According to the theory of traditional veterinary medicine, the placenta is divided into two basic syndrome categories of qi deficiency type and qi and blood stagnation type, and the corresponding prescription of the prescription and syndrome can obtain good clinical effect. Chinese patent application 2015102480864 discloses a Chinese medicinal composition for preventing and treating uterine diseases of new-born cows, which is prepared from 100-125 parts of motherwort, 36-48 parts of rhizoma sparganii, 35-45 parts of curcuma zedoary, 18-36 parts of safflower, 25-37 parts of angelica, 21-28 parts of ligusticum wallichii, 18-37 parts of cyperus rotundus and 18-25 parts of liquorice, and a Chinese patent application 201310167878X discloses a Chinese medicinal composition prepared from 20-80 parts of garden balsam seed, 20-60 parts of motherwort, 15-45 parts of angelica, 15-45 parts of peach kernel, 20-30 parts of safflower, 15-60 parts of myrrh, 15-30 parts of medicinal cyathula root, 10-35 parts of plantain seed, 15-60 parts of nutgrass galingale rhizome and 10-25 parts of dried ginger, which are all Chinese medicinal compositions aiming at the pathogenesis characteristics of no blood stasis of cow placenta, and are known from the patent description, the two traditional Chinese medicine compositions can effectively treat qi-blood stagnation type retained afterbirth of dairy cows, but the treatment effect for qi-deficiency type retained afterbirth is unclear.
Disclosure of Invention
The first purpose of the invention is to overcome the defects in the prior art, provide the traditional Chinese medicine composition for treating qi-deficiency type retained afterbirth of the dairy cow, and realize the purpose of safely and effectively treating qi-deficiency type retained afterbirth of the dairy cow.
The second object of the present invention is to provide a process for the preparation of the above composition.
A third object of the present invention is to provide the use of the above composition.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows is prepared from the following raw material medicines in parts by weight: 60-80 parts of motherwort, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus membranaceus, 30-40 parts of rhodiola rosea, 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 45-65 parts of angelica sinensis, 30-50 parts of ligusticum wallichii, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root and 15-20 parts of rose.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 80 parts of motherwort, 50 parts of codonopsis pilosula, 50 parts of astragalus membranaceus, 35 parts of rhodiola rosea, 40 parts of pollen typhae, 40 parts of trogopterus dung, 30 parts of rhizoma cyperi, 40 parts of mangnolia officinalis, 50 parts of fennel, 50 parts of angelica sinensis, 30 parts of ligusticum wallichii, 30 parts of eupatorium japonicum leaves, 40 parts of medicinal cyathula root and 20 parts of rose.
The preparation method of the traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of the dairy cow comprises the following steps of weighing the raw materials according to the proportion, mixing, cleaning, drying, crushing, sieving and uniformly stirring.
Further, the drying temperature is 65 ℃, and the screen mesh number is 50-150 meshes.
The application of the traditional Chinese medicine composition in preparing the medicine for preventing and treating qi deficiency type retained fetal membranes of the dairy cows.
The deficiency of qi in the placenta of the cow is caused by improper feeding, weak carcass, damaged primordial qi, over-production, damaged primordial qi, too long labor, excessive force during parturition, consumption of qi and blood or qi loss with blood, so that qi and blood are weak and weak to discharge the placenta. The traditional Chinese medicine composition selects the codonopsis pilosula for nourishing blood, tonifying middle-jiao and Qi; the astragalus root, radix astragali, invigorating qi and blood, the compatibility of two medicines is used, make qi congestion moist, the pneumatics blood circulation, make the blood stasis get and melt, the uterus is got and led to the throne, the uterus activity resumes normal, do benefit to the placenta to discharge; the rhodiola rosea has the effects of tonifying qi, activating blood, resisting fatigue, enhancing physical performance and accelerating postpartum recovery; trogopterus dung has the effects of promoting blood circulation and removing blood stasis and is used for treating various postpartum pains; raw cattail pollen can promote blood circulation, remove blood stasis, stop bleeding and treat stranguria; angelica sinensis has the effects of enriching blood, promoting blood circulation and removing blood stasis; the rhizoma ligustici wallichii is capable of activating blood and dissolving stasis, and promoting qi circulation and relieving pain; hou Po can direct qi downward, relieve epigastric distention and resolve phlegm; the fennel has the functions of regulating qi, dispelling cold, eliminating distension and relieving pain; rhizoma Cyperi can promote qi circulation and relieve pain; herba Lycopi can induce diuresis to alleviate edema, and treat postpartum stasis and abdominal pain; the motherwort herb induces diuresis to alleviate edema and treats endless lochiorrhea after parturition; radix Cyathulae has effects of promoting blood circulation and dredging channels, and can be used for treating postpartum abdominal pain due to blood stasis; the rose flower and the nutrient can dredge collaterals and help the efficacy of the medicine to play. The medicines are compatible, and have the effects of tonifying qi and nourishing blood, promoting blood circulation by removing blood stasis, promoting qi circulation to relieve pain, dredging and activating the channels and collaterals, strengthening physical strength and removing placenta, and the traditional Chinese medicine composition has the pathogenesis characteristics of qi deficiency type retained placenta of the dairy cow, so that the qi deficiency type retained placenta of the dairy cow can be effectively treated.
The invention has the following beneficial effects:
the traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows, provided by the invention, can effectively promote the discharge of the afterbirth, reduce the incidence rate of metritis, realize quick postpartum recovery, improve the reproductive performance of tested dairy cows, solve the problems of drug residues in dairy products caused by clinical treatment drug deficiency and hormone therapy and the like, and meet the medication requirements of green and healthy breeding in the modern dairy industry.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
The raw materials in the embodiment of the invention are all commercially available products.
Example 1
A preparation method of a traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows comprises the following steps: weighing 40kg of codonopsis pilosula, 60kg of astragalus membranaceus, 30kg of rhodiola rosea, 35kg of pollen typhae, 35kg of trogopterus dung, 20kg of rhizoma cyperi, 35kg of mangnolia officinalis, 60kg of fennel, 45kg of angelica sinensis, 40kg of ligusticum wallichii, 60kg of leonurus, 35kg of eupatorium japonicum leaves, 50kg of medicinal cyathula root and 15kg of rose according to the proportion of a formula, mixing, cleaning, drying at 65 ℃, crushing all the raw materials, sieving with a 150-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and treating qi deficiency.
Example 2
A preparation method of a traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows comprises the following steps: weighing 50kg of codonopsis pilosula, 50kg of astragalus membranaceus, 35kg of rhodiola rosea, 40kg of pollen typhae, 40kg of trogopterus dung, 30kg of rhizoma cyperi, 40kg of mangnolia officinalis, 50kg of fennel, 50kg of angelica sinensis, 30kg of ligusticum wallichii, 80kg of leonurus, 30kg of eupatorium japonicum leaves, 40kg of medicinal cyathula root and 20kg of rose according to the proportion of a formula, mixing, cleaning, drying at 65 ℃, crushing all the raw materials, sieving with a 120-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and treating qi deficiency.
Example 3
A preparation method of a traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows comprises the following steps: weighing 60kg of codonopsis pilosula, 70kg of astragalus membranaceus, 40kg of rhodiola rosea, 45kg of pollen typhae, 45kg of trogopterus dung, 25kg of rhizoma cyperi, 45kg of mangnolia officinalis, 70kg of fennel, 65kg of angelica sinensis, 50kg of ligusticum wallichii, 70kg of leonurus, 40kg of eupatorium japonicum leaves, 60kg of medicinal cyathula root and 17kg of rose according to the proportion of a formula, mixing, cleaning, drying at 65 ℃, crushing all the raw materials, sieving with a 80-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and treating qi deficiency.
Comparative example 1
The difference from example 2 is that rose and rhodiola rosea were not used, and the rest is the same.
Example 4
The traditional Chinese medicine composition disclosed by the invention is used for clinical test research on treatment of qi deficiency type retained fetal membranes of dairy cows:
1.1 test drugs
The Chinese medicinal composition of the embodiments 1 to 3 and the comparative example 1. Positive contrast medicine Tonic Qinggong powder (for animals).
1.2 test pasture
The test is carried out in large-scale cow breeding bases near Lanzhou, Zhangye, Yinchuan and Wuzhou in 2017, 6 months to 2018, 9 months. The management conditions and the feeding level of the pasture are similar, and a basic pasture production management database is established.
1.3 selection of animals
1.3.1 diagnostic criteria
The retention of the placenta of the milk cow means that the placenta cannot be timely discharged 12 hours after the milk cow parturition.
1.3.2 Standard of syndrome differentiation
And (3) dialectical standards: (1) the patients with all the main indications belong to the present syndrome;
(2) those with the primary index ① and the secondary index 2 belong to the original syndrome.
The main indications are ① retained placenta, ② placenta in earth grey and ③ pale white.
The secondary indications include ① inability to work with effort, ② cold ears and nose, ③ pale lochiorrhea and ④ weak and thready and weak pulse.
1.3.3 inclusion criteria
The retention time of the fetal membranes is 16 +/-4 hours, the fetal membranes are aged 3-8 years and have 2-5 times of birth, the body condition score is 2.5-4.0, the fetal membranes have no history of infection, the prenatal health is realized, the labor process is smooth, the fetal membranes are naturally delivered, no complications exist before and after the prenatal period, and the calves are healthy.
1.3.4 rejection Standard
The retention time of the placenta after delivery exceeds 20 hours, the placenta with qi and blood stagnation type can not be got suffered from the cattle, and the cattle suffered from abortion, twin fetuses, dead fetuses, postpartum paralysis, postpartum clinical mastitis, true stomach shift, postpartum fever (rectal temperature is more than or equal to 40 ℃), postpartum diarrhea and the cattle suffered from other anti-inflammatory or antibiotic treatment measures irrelevant to the study or the cows who participated in other clinical trials in the early period are excluded from the study.
1.4 test procedure
1.4.1 random grouping
Cattle with a deficiency of qi type retained afterbirth in accordance with this study were randomly divided into 5 groups, a control group (300), a test i group (example 1, 300), a test ii group (example 2, 300), a test iii group (example 3, 300) and a test iv group (comparative example 1, 300).
1.4.2 dosing regimens
Four groups of test patients are administrated according to the dose of 400 g/head, before the administration, the tested medicine is soaked in 20-25L of boiled water for 30 minutes, and the medicine is taken by oral administration 1 time per day after waiting for a warm period, and is continuously taken for 1-3 days. The tonifying and uterus-clearing powder is administered to the control group suffering cattle by irrigation in the same way at a dose of 400 g/head for 1-3 days.
1.5 detection index
1.5.1 general clinical signs after administration, the test cows were monitored for mental status, feeding rumination, and stool status.
1.5.2 retained fetal membrane expulsion events during the test period 1 test participant was specifically responsible for monitoring retained fetal membrane expulsion events and confirming uterine status and fetal membrane expulsion events by rectal examination 72 hours after the first dose. And recording the treatment time, retained fetal membrane discharge time, discharge state and the like of the tested dairy cow so as to evaluate the recent intervention effect of the traditional Chinese medicine composition on promoting retained fetal membrane discharge.
1.5.3 reproductive performance all the tested cows are oestrous and monitored and bred according to the prescribed breeding management program of the pasture. During the test period, collecting breeding and mating data of a test pasture, and monitoring and recording the parturition time, the first mating time after delivery, the mating times and the conception time of the tested dairy cow during the test period so as to evaluate the long-term intervention effect of the traditional Chinese medicine composition on the breeding performance of the tested dairy cow.
1.6 evaluation index and evaluation Standard of curative Effect
1.6.1 the main efficacy evaluation index is to promote retained afterbirth excretion, and mainly comprises retained afterbirth excretion rate within 72h of first administration, administration frequency, retained afterbirth excretion rate in one administration, and average time of retained afterbirth excretion. The calculation formula of each index is as follows:
1.6.2 the secondary efficacy evaluation index takes the breeding performance in 180 days after delivery as the secondary efficacy evaluation index. Wherein the reproductive performance index comprises the first mating time after delivery, the first mating pregnancy rate, the mating times, the non-pregnant time and the total pregnancy rate within 180 days after delivery.
1.7 statistics of data
Data analysis was performed using SPSS (version21.0). The baseline characteristics of the tested cows in the two groups are evaluated by one-way anova or Kruskal-Wallis, and mainly comprise the differences of age, fetal frequency, body condition score, retention time (medication time) of fetal membranes of the two groups of tested cows, administration times, average retention time of the retained fetal membranes after being discharged, mating times and the like. Chi fang test analysis evaluated the retained fetal membrane discharge rate within 72h of the first dose, retained fetal membrane discharge rate within one dose, first mating pregnancy rate and the difference in pregnancy rate within 180d after delivery for two groups of test cows. And evaluating the difference of the secondary infection rates of the metritis in the two groups of puerperium by using whether the retained fetal membranes are discharged as covariates and adopting logistic regression analysis. Taking the secondary infection rate, the fetal times, the mating times and the body condition score of the metritis in the puerperium as covariates, and analyzing the differences between the postnatal estrus time and the first estrus time and the non-pregnancy time by using Cox proportional risk regression. And if the test cow is not pregnant for 180 days after delivery or is bred for more than six times, taking the data as truncation data. All statistical tests were performed in a two-sided test, and differences were considered statistically significant when P < 0.05.
2 results
2.1 the Chinese medicinal composition of the invention can effectively promote retained fetal membranes to be discharged
Compared with the control drug group, the retention fetal membrane discharge rate of the tested dairy cows in 72h after the first administration of the traditional Chinese medicine composition of the embodiments 1 to 3 and the comparative example 1 is greatly improved (p <0.01), the administration frequency is obviously reduced (p <0.05), the retention fetal membrane discharge rate of one administration is greatly improved (p <0.01), and the average time of fetal membrane discharge is obviously shortened (p <0.05) in each experimental group. The result shows that the traditional Chinese medicine composition can effectively promote retained fetal membranes to be completely discharged as soon as possible.
Compared with the group of the comparative example 1, the retained afterbirth discharge rate of the tested cow in 72 hours after the first administration in each experimental group of the traditional Chinese medicine composition of the embodiments 1-3 of the invention is obviously improved (p is less than 0.05), and the administration times, the retained afterbirth discharge rate after the first administration and the retained afterbirth discharge duration do not reach statistical differences, but show certain improvement effect. The results are shown in Table 1. Experiments show that after the rhodiola rosea with the effects of resisting fatigue and enhancing physical strength and the rose which is auxiliary and has the effect of dredging collaterals are added, the Chinese medicinal composition has an obvious effect of promoting the discharge of retained fetal membranes.
TABLE 1 therapeutic effect of the Chinese medicinal composition of the present invention on promotion of retained fetal membrane discharge
Note: data in the same row with different capital letters indicates significant difference (p <0.05), and data in the same row with different capital letters indicates significant difference (p < 0.01).
2.2 the Chinese medicinal composition can improve the breeding performance of the tested dairy cows within 180 days after delivery
Compared with a control drug group, the traditional Chinese medicine composition provided by the invention has the advantages that the first-time postnatal mating time can be effectively shortened, the mating times can be reduced, the pregnancy rate within 180 days after delivery can be improved, the difference is obvious (p is less than 0.05), the first-time mating pregnancy rate of the tested dairy cow can be improved, the nonpregnant time can be shortened, the difference is extremely obvious (p is less than 0.01), the examples 1-3 and the comparative example 1 have equivalent influence on the reproductive performance of the postpartum dairy cow, the influence of the addition of roses and rhodiola rosea on the reproductive performance of the dairy cow is not obvious, and the results are shown in a table 2. Experiments show that the traditional Chinese medicine composition can effectively improve the postpartum reproductive performance of cattle with retained afterbirth.
Table 2 influence of the Chinese medicinal composition on the breeding performance of the tested cows within 180 days after delivery
Note: data in the same column with a different capital letter indicates significant difference (p <0.05), and data in the same column with a different capital letter indicates very significant difference (p < 0.01).
The results show that the traditional Chinese medicine composition can effectively promote the retained afterbirth to be discharged, can improve the reproductive performance of the tested dairy cow, and is an effective traditional Chinese medicine preparation for preventing and treating qi deficiency type afterbirth retention of the dairy cow.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of dairy cows is characterized by being prepared from the following raw material medicines in parts by weight: 60-80 parts of motherwort, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus membranaceus, 30-40 parts of rhodiola rosea, 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 45-65 parts of angelica sinensis, 30-50 parts of ligusticum wallichii, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root and 15-20 parts of rose.
2. The traditional Chinese medicine composition for preventing and treating qi-deficiency type retained fetal membranes of dairy cows according to claim 1, which is prepared from the following raw material medicines in parts by weight: 80 parts of motherwort, 50 parts of codonopsis pilosula, 50 parts of astragalus membranaceus, 35 parts of rhodiola rosea, 40 parts of pollen typhae, 40 parts of trogopterus dung, 30 parts of rhizoma cyperi, 40 parts of mangnolia officinalis, 50 parts of fennel, 50 parts of angelica sinensis, 30 parts of ligusticum wallichii, 30 parts of eupatorium japonicum leaves, 40 parts of medicinal cyathula root and 20 parts of rose.
3. The preparation method of the traditional Chinese medicine composition for preventing and treating qi deficiency type retained afterbirth of the dairy cow as claimed in claim 1 or 2, wherein the raw materials are weighed according to a ratio, mixed, cleaned, dried, crushed, sieved and uniformly stirred.
4. The preparation method of the traditional Chinese medicine composition for preventing and treating qi-deficiency type retained afterbirth of the dairy cow according to claim 3, wherein the drying temperature is 65 ℃, and the screening mesh number is 50-150 meshes.
5. The use of the Chinese medicinal composition of any one of claims 1-2 in the preparation of a medicament for preventing and treating qi deficiency type retained fetal membranes in dairy cows.
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