LU504023B1 - Traditional chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof - Google Patents
Traditional chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof Download PDFInfo
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- LU504023B1 LU504023B1 LU504023A LU504023A LU504023B1 LU 504023 B1 LU504023 B1 LU 504023B1 LU 504023 A LU504023 A LU 504023A LU 504023 A LU504023 A LU 504023A LU 504023 B1 LU504023 B1 LU 504023B1
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows, which is prepared from the following bulk drugs in parts by weight: 35-45 parts of typhae pollen, 35-45 parts of faeces trogopterori, 45-65 parts of angelicae sinensis radix, 30-50 parts of chuanxiong rhizoma, 20-30 parts of cyperi rhizoma, 35-45 parts of magnoliae officinalis cortex, 50-70 parts of foeniculi fructus, 60-80 parts of leonuri herba, 30-40 parts of herba lycopi, 40-60 parts of cyathulae radix, 40-60 parts of codonopsis radix, 50-70 parts of astragali radix, 10-15 parts of fluoritum, and 40-60 parts of lilii bulbus; it also provides a preparation method and an application thereof. The traditional Chinese medicine composition can effectively treat the postpartum pain of dairy cows, improve the animal welfare of modern animal husbandry, increase the milk yield of tested dairy cows, reduce the elimination rate, the incidence of metritis.
Description
DESCRIPTION LU504023
TRADITIONAL CHINESE MEDICINE COMPOSITION FOR PREVENTING AND
TREATING POSTPARTUM ABDOMINAL PAIN OF DAIRY COWS AND
PREPARATION METHOD THEREOF
The invention belongs to the technical field of veterinary drugs, and particularly relates to a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and a preparation method thereof.
Postpartum abdominal pain is one of the common clinical diseases in dairy cows, which mostly occurs within 1 - 3 days after delivery. The clinical symptoms are anorexia, rumination cessation, chills, cold ears, nose, limbs, hunching, abdominal kicking, tiredness, restless lying, vaginal discharge or blood stasis. For new cows, it is faced with the dual challenges of physiological function recovery and postpartum lactation. If it is not properly handled at the right time, postpartum abdominal pain will seriously affect the postpartum health recovery and the best production performance of cows, and then affect the pasture income. With the enhancement of animal welfare awareness of ranchers and the pursuit of the best production efficiency, postpartum pain management is regarded as an important item of postpartum health care in dairy farms.
At present, non-steroidal anti-inflammatory drugs, such as flunixin meglumine and meloxicam, are often used to manage postpartum pain in dairy cows. No or low selectivity of flunixin meglumine to cyclooxygenase leads to serious side effects, such as different degrees of gastrointestinal reactions, even intestinal bleeding and irritation.
Secondly, meloxicam can also cause many adverse reactions such as indigestion, such as vomiting, abdominal pain, constipation, flatulence and diarrhea. It can be seen that flunixin meglumine and meloxicam are commonly used drugs for postpartum paltJ504023 management in clinic, but the effect on postpartum abdominal pain in dairy cows is not ideal, and it may even cause negative gastrointestinal reactions. At the same time, the etiology of postpartum abdominal pain is complicated and uncertain. Therefore, the development of pharmaceutical preparations for postpartum abdominal pain is one of the important tasks of postpartum pain management in dairy cows. Chinese veterinary drugs have accumulated rich experience in treating postpartum abdominal pain. The research data show that the clinical effect of Chinese veterinary drugs in treating postpartum abdominal pain of dairy cows is exact, which meets the demand of modern dairy industry for healthy and green farming drugs.
The first purpose of the invention is to overcome the defects in the prior art and provide a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows, which can effectively prevent and treat postpartum abdominal pain of dairy cows.
A second object of the present invention is to provide a preparation method of the above composition.
A third object of the present invention is to provide an application of the above composition.
The purpose of the invention is specifically realized by the following technical schemes: a Chinese medicinal composition for preventing and treating postpartum abdominal pain of dairy cows is prepared from the following bulk drugs in parts by weight: 35-45 parts of typhae pollen, 35-45 parts of faeces trogopterori, 45-65 parts of angelicae sinensis radix, 30-50 parts of chuanxiong rhizoma, 20-30 parts of cyperi rhizoma, 35-45 parts of magnoliae officinalis cortex, 50-70 parts of foeniculi fructus, 60-80 parts of leonuri herba, 30-40 parts of herba lycopi, 40-60 parts of cyathulae radix, 40-60 parts of codonopsis radix, 50-70 parts of astragali radix, 10-15 parts of fluoritum, and 40-60 parts of lilii bulbus.
Preferably, it is prepared from the following bulk drugs in parts by weight: 40 parts bE504023 typhae pollen, 40 parts of faeces trogopterori, 50 parts of angelicae sinensis radix, 30 parts of chuanxiong rhizoma, 30 parts of cyperi rhizoma, 40 parts of magnoliae officinalis cortex, 50 parts of foeniculi fructus, 80 parts of leonuri herba, 30 parts of herba lycopi, 40 parts of cyathulae radix, 50 parts of codonopsis radix, 50 parts of astragali radix, 12 parts of fluoritum, and 50 parts of lilii bulbus.
A preparation method of the above traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows includes weighing each raw material according to the proportion, mixing, cleaning and drying them except for fluoritum, crushing each raw material through a sieve and mixing them well.
Further, the drying temperature is 65°C, and the sieving mesh number is 80-150 meshes.
An application of the traditional Chinese medicine composition in preparing medicines for preventing and treating postpartum abdominal pain of dairy cows.
Postpartum abdominal pain in dairy cows is mostly caused by poor gi and blood circulation and blood stasis. The traditional Chinese medicine composition of the invention selects faeces trogopterori to promote blood circulation and dissipate blood stasis to treat postpartum pains; raw typhae pollen promotes blood circulation to dissipate blood stasis, stops bleeding and relieves stranguria; angelicae sinensis radix enriches blood, promotes blood circulation and removes blood stasis; chuanxiong rhizoma promotes blood circulation, removes blood stasis, promotes qi circulation and relieves pain; magnoliae officinalis cortex can relieve phlegm by relaxing the qi; foeniculi fructus regulates qi and dispels cold, and relieves bloating and pain; cyperi rhizoma promotes gi and relieves pain; cyathulae radix can promote blood circulation and dredge menstruation, and treat postpartum abdominal pain due to blood stasis; herba lycopi and leonuri herba induce diuresis to reduce swelling and treat postpartum blood stasis, abdominal pain and lochia; codonopsis radix and astragali radix can tonify the middle energizer and promote the production of body fluid, and are mainly used for treating spleen and stomach weakness, fatigue and fatigue; fluoritum calms the nerves and warms the palace; lilii bulbus moistens the brain and calms the nerves. The combination of various medicines has the effects of promoting blood circulation, removing blodd/504023 stasis, promoting qi circulation to relieve pain, inducing diuresis to reduce swelling, benefiting the stomach and intestines, tonifying deficiency and calming the nerves, and warming the uterus, so it can make lochia flow smoothly and abdominal pain heal itself.
The traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows has the following beneficial effects: the traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows can effectively treat postpartum pain of dairy cows, improve animal welfare of modern animal husbandry, increase milk yield of tested dairy cows, reduce the elimination rate, the incidence of metritis and the incidence of mastitis within 30 days after delivery, boost the postpartum health management level of dairy cows, solve the problem of lack of clinical treatment drugs, and meet the drug demand of green and healthy breeding of modern dairy industry.
Hereinafter, the preferred embodiments of the present invention will be described, and it should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not used to limit the present invention.
The raw materials in the embodiment of the invention are all products available in the market.
Embodiment 1
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weigh typhae pollen 35 kg, faeces trogopterori 35 kg, angelicae sinensis radix 45 kg, chuanxiong rhizoma 40 kg, cyperi rhizoma 20 kg, magnoliae officinalis cortex 35 kg, foeniculi fructus 60 kg, leonuri herba 60 kg, herba lycopi 35 kg, cyathulae radix 50 kg, codonopsis radix 40 kg, astragali radix 60 kg, fluoritum 10 kg and lilii bulbus 40 kg, all ingredients, except fluoritum, are mixed, purified and dried at 65°C; all ingredients are crushed, sieved through 150 mesh, stirred well and sub-packed to obtain a traditionall504023
Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows.
Embodiment 2
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weigh typhae pollen 40 kg, faeces trogopterori 40 kg, angelicae sinensis radix 50 kg, chuanxiong rhizoma 30 kg, cyperi rhizoma 30 kg, magnoliae officinalis cortex 40 kg, foeniculi fructus 50 kg, leonuri herba 80 kg, herba lycopi 30 kg, cyathulae radix 40 kg, codonopsis radix 50 kg, astragali radix 50 kg, fluoritum 12 kg, and lilii bulbus 50 kg, mix them except fluoritum, and clean them and drying at 65°C; all ingredients are crushed, sieved through 120 mesh, stirred well and sub-packed to obtain a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy
COWS.
Embodiment 3
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weigh typhae pollen 45 kg, faeces trogopterori 45 kg, angelicae sinensis radix 65 kg, chuanxiong rhizoma 50 kg, cyperi rhizoma 25 kg, magnoliae officinalis cortex 45 kg, foeniculi fructus 70 kg, leonuri herba 70 kg, herba lycopi 40 kg, cyathulae radix 60 kg, codonopsis radix 60 kg, astragali radix 70 kg, fluoritum 15 kg, and lilii bulbus 20 kg, mix them except fluoritum, and clean them and drying at 65°C; all ingredients are crushed, sieved through 80 mesh, stirred well and sub-packed to obtain a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy
COWS.
Comparative embodiment 1
The difference from Embodiment 2 is that fluoritum and lilii bulbus are not used, and the rest are the same.
Embodiment 4 LU504023
Clinical experimental study on the treatment of postpartum abdominal pain in dairy cows with the traditional Chinese medicine composition of the invention: 1.1 Test drugs
Traditional Chinese medicine compositions of Embodiments 1-3 and Comparative embodiment 1 of the present invention. Positive control drug of flunixin meglumine injection.
Experimental pasture
The experiment is conducted in large-scale dairy farming bases near Yinchuan,
Wuzhong, Lanzhou and Zhangye from September 2017 to March 2019. The management conditions and feeding level of the included pastures are similar, and a basic database of pasture production management is established.
Animal selection 1.3.1 Diagnostic criteria
The selected animal has the main indication and two secondary indications, that is, it is diagnosed as postpartum abdominal pain of dairy cows. (1) Main indications: cows have abdominal pain within 1-3 days after delivery, which is manifested as hunching, kicking, exertion, muscle tremor, and restless lying. (2) Secondary indications: (1) listlessness; (2) diet is abolished; (3) mouth color is blue and white; (4) the pulse condition is heavy.
Inclusion criteria: 3-8 years old, 2-5 births, physical condition score of 2.5-4.0, no history of infectious diseases, prenatal health, smooth labor process, natural delivery, no complications before and after delivery, and healthy calves.
Rejection criteria
Cows suffering from postpartum for more than 3 days, cows suffering from retained placenta, postpartum clinical mastitis, abomasum displacement, postpartum fever (rectal temperature 240°C), postpartum diarrhea, and cows receiving other anti-inflammatory or analgesic treatment measures unrelated to this study or participating in other clinical trials in the early stage are excluded from this study.
Test procedure
1.4.1 Random grouping LU504023
Cows suffering from postpartum abdominal pain are randomly divided into five groups: control group (300 cows), experimental group | (300 cows, Embodiment 1), experimental group Il (300 cows, Embodiment 2), experimental group Ill (300 cows, Embodiment 3) and experimental group IV (300 cows, Comparative embodiment 1).
Administration regimen
Four groups of experimental cows are given drugs according to the dosage of 400 g/cow.
Before administration, the tested drugs are soaked in 20-25 L boiling water for 30 min, waiting for the temperature, and taken orally once a day for 3 days. In the control group, the infected cows are given flunixin meglumine 25 mL/cow and intramuscular injection for 3 days.
Detection indicator
After administration, the mental state, rumination and defecation of the cows are monitored. The pain relief status is judged by the pain indexes such as hunching back, wagging tail, kicking abdomen and trying hard. The secondary diseases such as mastitis and metritis within 30 days after delivery and the elimination of the tested cows are statistically analyzed. The body temperature is continuously detected for 7 days (> 39.5°C for fever); after being transferred from the delivery room to the milking barn, the milk yield is continuously measured, and the changes of milk yield of the tested cows on the 30th postpartum day are compared.
Criteria for judging curative effect
Recovery: mental state and appetite are normal, and the main indications of abdominal pain of the tested cows return to normal within 48 hours after the first medication, which is judged as recovery.
Effective. the mental state is poor, and the appetite decreases slightly. The main indications of abdominal pain in the tested cows return to normal within 49-72 hours after the first medication, and it is judged as effective.
Invalid: depressed spirit, loss of appetite, decreased rumination, increased water consumption or unwillingness to drink water, and abdominal pain symptoms such as hunchback, tail lifting and muscle tremor from time to time, which are judged as invalid.
Statistics LU504023
The data are analyzed by SPSS®(Version 17.0). Chi-squared test is used to evaluate the cure rate of the two groups of dairy cows, and milk production is tested using a two-sided test for both groups, where p < 0.05 is considered a statistically significant difference in the test.
Result 1.8.1 Clinical effect of the traditional Chinese medicine composition in treating postpartum abdominal pain of dairy cows
The clinical effects of the traditional Chinese medicine compositions of the embodiments and comparative embodiments and the control drugs in treating postpartum abdominal pain of dairy cows are shown in Table 1. Compared with the control group, the cure rate and total effective rate of the traditional Chinese medicine compositions in the embodiments and comparative embodiments of the present invention are significantly improved, with a significant difference (p<0.01), while there is no significant difference among the traditional Chinese medicine compositions in the embodiments of the present invention (p>0.05). The results show that the traditional Chinese medicine composition can effectively treat postpartum abdominal pain of dairy cows.
Compared with group 1 of comparative embodiments 1, the total effective rate of the tested cows in each experimental group of the traditional Chinese medicine composition of Embodiments 1-3 of the invention has been obviously improved (p<0.05), and the results are shown in Table 1. The experiment shows that adding two kinds of auxiliary
Chinese medicines, fluoritum and lili bulbus, to the Chinese medicine composition can obviously promote the treatment of postpartum abdominal pain in dairy cows.
Table 1 Clinical efficacy test results of the traditional Chinese medicine composition 504023 treating postpartum abdominal pain of dairy cows.
Total
Recovery |Effective [Effective Inefficiency.
Heal/cow Invalid/cow effective rate/% /cow rate/% % rate/%
Control 150 50.04 75 25.0 75 25.0 75.04 group
Experiment 210 70.08 77 25.7 13 4.3 95.7Ba al group
Experiment 225 75.08 70 23.3 5 1.7 08.382 al group II
Experiment 216 72.08 75 25.0 3.0 97.0Ba al group Ill
Experiment 205 69.35 22.7 27 91.08Bb al group IV
Note: there is no significant difference between the data in the same column with the same letter (p> 0.05), those with different lowercase letters (P < 0.05) and those with different uppercase letters (p< 0.01).
The influence of the traditional Chinese medicine composition on the health status of the tested dairy cows within 30 days after delivery.
The clinical effects of the traditional Chinese medicine compositions of the embodiments and comparative embodiments and the control drugs in treating postpartum abdominal pain of dairy cows are shown in Table 2. Compared with the control group, the elimination rate, incidence of mastitis and metritis of the traditional Chinese medicine compositions in the embodiments and comparative embodiments of the present invention are decreased, and the milk yield increased, with a significant difference (p<0.01), while there is no significant difference among the traditional Chinese medicine compositions in the embodiments and comparative embodiments (p>0.05). From tH&J504023 experimental data, it can be seen that the elimination rate of dairy cows and the incidence of endometritis in each experimental group of Embodiments 1-3 are lower than those in Comparative embodiment 1, but there is no statistically significant difference.
The incidence of mastitis and milk production in Comparative Embodiment 1 are equivalent to those in Embodiments 1-3. The results show that the traditional Chinese medicine composition can effectively improve the postpartum health level of the tested cows and increase the milk yield, and the addition of fluoritum and lili bulbus can improve the postpartum elimination rate and the incidence of endometritis of dairy cows.
Table 2 Effect of Chinese traditional medicine composition of the invention on health status of dairy cows within 30 days after delivery.
Number ofElimination Incidence o of Milk yield /(kg/d) heads/cows |rate/% mastitis/cow metritis/%
SS a ee 300 5.04 4.37 30.74 33.5+8.44 group
Experime ntal group300 1.38 2.08 12.08 39.8+5.85
Experime ntal group300 1.08 1.08 11.38 42.0+9.75
Il
Experime ntal group300 1.78 1.38 13.08 39.9+7.35
Ill
Experime
IV
Note: there is no significant difference between the data in the same column with tH&J504023 same letter (p> 0.05), those with different lowercase letters (p< 0.05) and those with different uppercase letters (p< 0.01).
The above results show that the traditional Chinese medicine composition can effectively control the postpartum abdominal pain of dairy cows, including reducing the proportion of hunchback, tail lifting and muscle tremor, improving animal welfare, improving the postpartum health level of the tested cows and increasing milk yield.
The above describes only the preferred embodiments of the present invention, and it is not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, it is still possible for a person skilled in the art to modify the technical scheme described in the foregoing embodiments or to replace some technical features equally. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the invention should be included in the protection scope of the invention.
Claims (5)
1. A Chinese medicinal composition for preventing and treating postpartum abdominal pain in dairy cows, characterized by being prepared from the following raw materials in parts by weight: 35-45 parts of typhae pollen, 35-45 parts of faeces trogopterori, 45-65 parts of angelicae sinensis radix, 30-50 parts of chuanxiong rhizoma, 20-30 parts of cyperi rhizoma, 35-45 parts of magnoliae officinalis cortex, 50-70 parts of foeniculi fructus, 60-80 parts of leonuri herba, 30-40 parts of herba lycopi, 40-60 parts of cyathulae radix, 40-60 parts of codonopsis radix, 50-70 parts of astragali radix, 10-15 parts of fluoritum, and 40-60 parts of lilii bulbus.
2. The traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows according to claim 1, characterized by being prepared from the following raw materials in parts by weight: 40 parts of typhae pollen, 40 parts of faeces trogopterori, 50 parts of angelicae sinensis radix, parts of chuanxiong rhizoma, 30 parts of cyperi rhizoma, 40 parts of magnoliae officinalis cortex, 50 parts of foeniculi fructus, 80 parts of leonuri herba, 30 parts of herba lycopi, 40 parts of cyathulae radix, 50 parts of codonopsis radix, 50 parts of astragali radix, 12 parts of fluoritum, and 50 parts of lilii bulbus.
3. A preparation method of the traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows according to claim 1 or 2, characterized by comprising weighing each raw material according to the proportion, mixing, cleaning and drying except for fluoritum, crushing each raw material through a sieve and mixing well.
4. The preparation method of the traditional Chinese medicine composition fbH504023 preventing and treating postpartum abdominal pain of dairy cows according to claim 3, characterized in that the drying temperature is 65°C, and the sieving mesh is 80-150 meshes.
5. An application of the Chinese medicinal composition according to any one of claims 1-2 in preparing medicines for preventing and treating postpartum abdominal pain of dairy cows.
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| Application Number | Priority Date | Filing Date | Title |
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| LU504023A LU504023B1 (en) | 2023-04-21 | 2023-04-21 | Traditional chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| LU504023A LU504023B1 (en) | 2023-04-21 | 2023-04-21 | Traditional chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof |
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| Country | Link |
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