CN110882345B - Traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof - Google Patents

Traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof Download PDF

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CN110882345B
CN110882345B CN201911389021.6A CN201911389021A CN110882345B CN 110882345 B CN110882345 B CN 110882345B CN 201911389021 A CN201911389021 A CN 201911389021A CN 110882345 B CN110882345 B CN 110882345B
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traditional chinese
abdominal pain
chinese medicine
medicine composition
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CN110882345A (en
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黎玉琼
崔东安
于洋
赵正伟
高海慧
马吉锋
岳彩娟
张俊丽
梁小军
马青
马小明
额尔和华
王建东
王川
王晓薇
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Institute Of Animal Science Ningxia Academy Of Agricultural And Forestry Sciences
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows, which is prepared from the following raw material medicines in parts by weight: 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 45-65 parts of angelica, 30-50 parts of ligusticum wallichii, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 60-80 parts of motherwort, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus mongholicus, 10-15 parts of amethyst and 40-60 parts of lily; and provides a preparation method and application thereof. The traditional Chinese medicine composition can effectively treat postpartum pain of dairy cows, promote animal welfare of modern animal husbandry, increase milk yield of tested dairy cows, reduce elimination rate, metritis incidence rate and mastitis incidence rate of the dairy cows within 30 days after delivery, boost postpartum health management level of herds in a pasture, solve the problem of lack of clinical treatment medicines, and meet the medication requirement of green and healthy breeding of modern milk industry.

Description

Traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and a preparation method thereof.
Background
Postpartum abdominal pain is one of the more common diseases of dairy cows in clinic, and is mostly caused within 1-3 days after delivery, and symptoms such as anorexia, rumination stoppage, intolerance of cold, cold ears, noses, limbs, arch waist, abdomen kicking, effort and responsibility, restlessness in lying and standing, vaginal discharge secretion or blood stasis and the like are clinically diagnosed. For newly born cows, the two challenges of physiological function recovery and postpartum lactation are faced, and if the cows are not suitable for treatment, postpartum abdominal pain inevitably affects postpartum health recovery and optimal production performance of the cows, so that pasture income is affected. With the increasing welfare awareness of pasture initiatives and the pursuit of the best production benefits, the management of postpartum pain is taken as an important item of postpartum health care by the dairy farms.
At present, non-steroidal anti-inflammatory drugs, such as flunixin meglumine, meloxicam and other drugs, are mostly adopted clinically to manage postpartum pain of cows. Flunixin meglumine is not selective or has low selectivity on cyclooxygenase, so that serious side effects such as gastrointestinal reaction of different degrees, even intestinal hemorrhage, high irritation and the like are caused. Secondly, meloxicam can also cause many adverse reactions such as dyspepsia, vomiting, abdominal pain, constipation, flatulence and diarrhea. Therefore, flunixin meglumine and meloxicam are frequently used in clinic as medicines for managing postpartum pain, but the effect on postpartum abdominal pain of cows is not ideal, and even gastrointestinal reaction negative effect can be caused. Meanwhile, the etiology of postpartum abdominal pain is complicated and uncertain. Therefore, the development of pharmaceutical preparations for postpartum abdominal pain is one of the important tasks required for management of postpartum pain in dairy cows. The traditional Chinese veterinary medicine for treating postpartum abdominal pain has rich syndrome treatment experience, and research data shows that the clinical curative effect of the traditional Chinese veterinary medicine for treating postpartum abdominal pain of dairy cows is exact, and the traditional Chinese veterinary medicine meets the requirements of healthy and green breeding medicines in modern dairy industry.
Disclosure of Invention
The first purpose of the invention is to overcome the defects in the prior art and provide the traditional Chinese medicine composition for preventing and treating the postpartum abdominal pain of the dairy cow, which can effectively prevent and treat the postpartum abdominal pain of the dairy cow.
The second object of the present invention is to provide a process for the preparation of the above composition.
A third object of the present invention is to provide the use of the above composition.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows is prepared from the following raw material medicines in parts by weight: 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 45-65 parts of angelica, 30-50 parts of ligusticum wallichii, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 60-80 parts of motherwort, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus mongholicus, 10-15 parts of amethyst and 40-60 parts of lily.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 40 parts of cattail pollen, 40 parts of trogopterus dung, 50 parts of Chinese angelica, 30 parts of ligusticum wallichii, 30 parts of rhizoma cyperi, 40 parts of mangnolia officinalis, 50 parts of fennel, 80 parts of motherwort, 30 parts of eupatorium japonicum leaves, 40 parts of medicinal cyathula root, 50 parts of codonopsis pilosula, 50 parts of astragalus mongholicus, 12 parts of amethyst and 50 parts of lily.
The preparation method of the traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of the dairy cow comprises the steps of weighing the raw materials according to the proportion, mixing, cleaning and drying the raw materials except amethyst, crushing and sieving the raw materials, and uniformly stirring the raw materials.
Further, the drying temperature is 65 ℃, and the screen mesh number is 80-150 meshes.
The application of the traditional Chinese medicine composition in preparing the medicine for preventing and treating postpartum abdominal pain of the dairy cows.
Postpartum abdominal pain of cows is caused by unsmooth circulation of qi and blood and stasis. The traditional Chinese medicine composition adopts trogopterus dung for promoting blood circulation and removing blood stasis, and treats various postpartum pains; raw cattail pollen can promote blood circulation, remove blood stasis, stop bleeding and treat stranguria; angelica sinensis has the effects of enriching blood, promoting blood circulation and removing blood stasis; the rhizoma ligustici wallichii is capable of activating blood and dissolving stasis, and promoting qi circulation and relieving pain; hou Po can direct qi downward, relieve epigastric distention and resolve phlegm; the fennel has the functions of regulating qi, dispelling cold, eliminating distension and relieving pain; rhizoma Cyperi can promote qi circulation and relieve pain; radix Cyathulae has effects of promoting blood circulation and dredging channels, and can be used for treating postpartum abdominal pain due to blood stasis; herba Lycopi and herba Leonuri have effects of inducing diuresis and relieving swelling, and can be used for treating puerperal stagnation, abdominal pain, and lochiorrhea; radix Codonopsis and radix astragali have effects of invigorating spleen and replenishing qi, and promoting fluid production, and can be used for treating spleen and stomach weakness, and asthenia; purple quartz has effects of tranquilizing mind and warming uterus; the lily has the effects of nourishing brain and soothing nerves, and the combination of the medicines has the effects of activating blood and removing stasis, promoting qi circulation and relieving pain, inducing diuresis and reducing edema, benefiting stomach and intestine, tonifying deficiency and tranquilizing mind and warming uterus, so that lochiorrhea can be smoothened and abdominal pain can be healed.
The invention has the following beneficial effects:
the traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of the dairy cows, provided by the invention, can effectively treat postpartum pain of the dairy cows, improve animal welfare of modern animal husbandry, increase milk yield of tested dairy cows, reduce elimination rate, metritis incidence and mastitis incidence of the dairy cows within 30 days after delivery, boost health management level of dairy herds in the pasture after delivery, solve the problem of lack of clinical treatment medicines, and meet the medication requirement of green and healthy breeding in modern dairy industry.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
The raw materials in the embodiment of the invention are all commercially available products.
Example 1
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weighing 35 kg of cattail pollen, 35 kg of trogopterus dung, 45 kg of angelica, 40 kg of ligusticum wallichii, 20 kg of rhizoma cyperi, 35 kg of mangnolia officinalis, 60 kg of fennel, 60 kg of leonurus, 35 kg of eupatorium japonicum leaves, 50 kg of medicinal cyathula root, 40 kg of codonopsis pilosula, 60 kg of astragalus mongholicus, 10 kg of amethyst and 40 kg of lily according to the proportion of a formula, mixing the components except the amethyst, cleaning, drying at 65 ℃, crushing all the raw materials, sieving by a 150-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and.
Example 2
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weighing 40 kg of cattail pollen, 40 kg of trogopterus dung, 50 kg of angelica, 30 kg of ligusticum wallichii, 30 kg of rhizoma cyperi, 40 kg of mangnolia officinalis, 50 kg of fennel, 80 kg of motherwort, 30 kg of eupatorium japonicum leaves, 40 kg of medicinal cyathula root, 50 kg of codonopsis pilosula, 50 kg of astragalus mongholicus, 12 kg of amethyst and 50 kg of lily according to the proportion of a formula, mixing the components except the amethyst, cleaning, drying at 65 ℃, crushing all the raw materials, sieving by a 120-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and treating.
Example 3
A preparation method of a traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows comprises the following steps: weighing 45 kg of cattail pollen, 45 kg of trogopterus dung, 65 kg of angelica, 50 kg of ligusticum wallichii, 25 kg of rhizoma cyperi, 45 kg of mangnolia officinalis, 70 kg of fennel, 70 kg of leonurus, 40 kg of eupatorium japonicum leaves, 60 kg of medicinal cyathula root, 60 kg of codonopsis pilosula, 70 kg of astragalus mongholicus, 15 kg of amethyst and 20 kg of lily according to the proportion of a formula, mixing the components except the amethyst, cleaning, drying at 65 ℃, crushing all the raw materials, sieving by a 80-mesh sieve, uniformly stirring, and subpackaging to obtain the traditional Chinese medicine composition powder for preventing and.
Comparative example 1
The difference from example 2 was that amethyst and lily were not used, and the rest was the same.
Example 4
The clinical trial research on the treatment of postpartum abdominal pain of the dairy cows by the traditional Chinese medicine composition disclosed by the invention comprises the following steps:
1.1 test drugs
The Chinese medicinal compositions of examples 1-3 and comparative example 1 of the present invention. Flunixin meglumine injection as positive control drug.
Test pasture
The test is carried out in a large-scale cow breeding base near Yinchuan, Wuzhou, Lanzhou and Zhangye from 09 months in 2017 to 03 months in 2019. The management conditions and the feeding level of the pasture are similar, and a basic pasture production management database is established.
Selection of animals
1.3.1 diagnostic criteria
Has main indications and 2 secondary indications, namely, the postpartum abdominal pain of the dairy cow is confirmed. (1) The main indications are as follows: the abdominal pain is manifested as hunching, kicking, effort and muscular tremor, and restlessness within 1-3 days after delivery. (2) Secondary indications: firstly, the spirit is not vibrating; second, the diet is exhausted; ③ the mouth color is bluish white; fourthly, the pulse condition is deep and wiry.
Inclusion criteria
The calf born by the method is 3-8 years old, 2-5 births, the body condition score is 2.5-4.0, the history of infectious diseases does not exist, the prenatal period is healthy, the labor process is smooth, natural delivery is realized, complications do not exist before and after the prenatal period, and the born calf is healthy.
Rejection criteria
Cows with more than 3 days postpartum, cows with retained afterbirth, clinical mastitis, displacement of the true stomach, postpartum fever (rectal temperature of 40 ℃ or higher), cows with postpartum diarrhea, and cows who received other anti-inflammatory or analgesic treatment measures unrelated to the study or had previously participated in other clinical trials were excluded from the study.
Test procedure
1.4.1 random grouping
Postpartum tormina cattle in accordance with this study were randomized into 5 groups, control (300), trial i (example 1, 300), trial ii (example 2, 300), trial iii (example 3, 300) and trial iv (comparative example 1, 300).
Dosing regimens
Four groups of experimental cattle are administrated according to the dose of 400 g/head, before the administration, the tested medicine is soaked in 20-25L of boiled water for 30 minutes, and the patient waits for warm and is orally administrated 1 time per day for 3 days continuously. The control group suffered from cattle, and flunixin meglumine was administered by drenching at a dose of 25 ml/head, and intramuscular injection was carried out for 3 days.
Detecting the index
After dosing, the test cows were monitored for mental status, ingestion of ruminants, and stool. And judging the pain relieving condition through pain indexes such as dorsum arcus, tail rocking, abdomen kicking, knoop and the like after the tested dairy cow is delivered. Carrying out statistical analysis on secondary diseases such as mastitis, metritis and the like within 30 days after delivery and the elimination condition of the tested dairy cows; continuously detecting the body temperature (fever is detected at the temperature of more than 39.5 ℃) for 7 days; and continuously measuring the milk yield after the dairy cow is transferred from the delivery room to a lactating cow house, and comparing the change of the milk yield of the tested dairy cow on the 30 th day after delivery.
Criteria for therapeutic effect
And (3) healing: the mental state and the appetite are normal, the main indications of the abdominal pain of the tested dairy cows are recovered within 48 hours after the first administration, and the dairy cows are judged to be recovered.
The method has the following advantages: the mental state is not good enough, the appetite is slightly reduced, and the main indications of abdominal pain of the tested dairy cows are recovered to be normal within 49-72 hours after the first medication, so that the effect is judged.
And (4) invalidation: the symptoms of abdominal pain such as the arch back, the tail lifting, the muscular tremor and the like are occasionally manifested by depression of the spirit, anorexia, reduction of rumination, increase of water intake or no desire to drink water, and are judged to be invalid.
Data statistics
Data analysis was performed using SPSS @ (Version 17.0). The chi-square test evaluates the cure rate of two groups of tested cows, the milk yield adopts bilateral test,pdifferences tested were considered statistically significant < 0.05.
Results
1.8.1 clinical effects of the Chinese medicinal composition for treating postpartum abdominal pain of dairy cow
The clinical effects of the traditional Chinese medicine composition and the control drug of the embodiment and the comparative example of the invention on treating postpartum abdominal pain of dairy cows are shown in table 1. Compared with the control group, the cure rate and the total effective rate of the traditional Chinese medicine composition of the embodiment and the comparative example are obviously improved, and the difference is very obvious (p<0.01) of the composition of the present invention, while the composition of the present invention is not clear between the groupsShow the difference (p>0.05). The result shows that the traditional Chinese medicine composition can effectively treat postpartum abdominal pain of the dairy cow.
Compared with the group of the comparative example 1, the total effective rate of the tested cows in each experimental group of the traditional Chinese medicine composition of the embodiment 1-3 of the invention is obviously improved (p<0.05), the results are shown in table 1. Experiments show that the traditional Chinese medicine composition has an obvious promoting effect on the treatment of postpartum abdominal pain of cows after the purple quartz and the lily are added into the traditional Chinese medicine composition.
Table 1 clinical efficacy test results of the traditional Chinese medicine composition for treating postpartum abdominal pain of dairy cows
Healing/head Rate of recovery/%) Effective/head Effective rate% Invalid/head Non efficiency/%) Total effective rate/%)
Control group 150 50.0A 75 25.0 75 25.0 75.0A
Test group I 210 70.0B 77 25.7 13 4.3 95.7Ba
Test II group 225 75.0B 70 23.3 5 1.7 98.3Ba
Test group III 216 72.0B 75 25.0 9 3.0 97.0Ba
Test group IV 205 68.3B 68 22.7 27 9.0 91.0Bb
Note: the same column data with the same letters are not significantly different (p> 0.05), marked with different lower case letters (significantly different)p< 0.05), marked with different capital letters (significantly different)p＜0.01）。
The traditional Chinese medicine composition of the invention has influence on the health condition of the tested dairy cow within 30 days after delivery
The clinical effects of the traditional Chinese medicine composition and the control drug of the embodiment and the comparative example of the invention on treating postpartum abdominal pain of dairy cows are shown in table 2. Compared with the control group, the traditional Chinese medicine composition of the embodiment and the comparative example of the invention has the advantages of reduced elimination rate, mastitis incidence and metritis incidence, increased milk yield and very obvious difference (p<0.01) of the composition of the present invention and the comparative examples, but there was no significant difference between the compositions of the present invention and the comparative examples: (p>0.05). It can be seen from the experimental data that the elimination rate and endometritis incidence rate of the cows in each test group of examples 1-3 are lower than those in comparative example 1, but the statistical difference is not achieved, and the incidence rate and milk yield of mastitis in the test group of comparative example 1 are equivalent to those in examples 1-3. The results show that the traditional Chinese medicine composition can effectively improve the postpartum health level of tested flocks and increase the milk yield, and the addition of amethyst and lily has certain improvement effect on the postpartum culling rate and the incidence of endometritis of the dairy cows.
TABLE 2 Effect of the Chinese medicinal composition of the present invention on the health condition of the tested cows within 30 days after delivery
Number of heads/head Elimination ratio/% Incidence/head of mastitis Metritis incidence/%) Milk yield/(kg/d)
Control group 300 5.0A 4.3A 30.7A 33.5±8.4A
Test group I 300 1.3B 2.0B 12.0B 39.8±5.8B
Test II group 300 1.0B 1.0B 11.3B 42.0±9.7B
Test group III 300 1.7B 1.3B 13.0B 39.9±7.3B
Test group IV 300 1.9B 1.7B 18.0B 39.9±7.3B
Note: the same column data with the same letters are not significantly different (p> 0.05), marked with different lower case letters (significantly different)p< 0.05), marked with different capital letters (significantly different)p＜0.01）。
The results show that the traditional Chinese medicine composition can effectively control the postpartum abdominal pain of the dairy cattle, including reducing the proportion of bow backs, tail lifting and muscle tremor, improving the welfare of animals, improving the postpartum health level of tested cattle groups and increasing the milk yield.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. A traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows is characterized by being prepared from the following raw material medicines in parts by weight: 35-45 parts of cattail pollen, 35-45 parts of trogopterus dung, 45-65 parts of angelica, 30-50 parts of ligusticum wallichii, 20-30 parts of rhizoma cyperi, 35-45 parts of mangnolia officinalis, 50-70 parts of fennel, 60-80 parts of motherwort, 30-40 parts of eupatorium japonicum leaves, 40-60 parts of medicinal cyathula root, 40-60 parts of codonopsis pilosula, 50-70 parts of astragalus mongholicus, 10-15 parts of amethyst and 40-60 parts of lily.
2. The traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows according to claim 1, which is prepared from the following raw material medicines in parts by weight: 40 parts of cattail pollen, 40 parts of trogopterus dung, 50 parts of Chinese angelica, 30 parts of ligusticum wallichii, 30 parts of rhizoma cyperi, 40 parts of mangnolia officinalis, 50 parts of fennel, 80 parts of motherwort, 30 parts of eupatorium japonicum leaves, 40 parts of medicinal cyathula root, 50 parts of codonopsis pilosula, 50 parts of astragalus mongholicus, 12 parts of amethyst and 50 parts of lily.
3. The preparation method of the traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of the dairy cow according to claim 1 or 2, characterized in that the raw materials are weighed according to a ratio, mixed, cleaned and dried except amethyst, crushed, sieved and uniformly stirred;
the drying temperature is 65 ℃, and the mesh number is 80-150 meshes.
4. The use of a Chinese medicinal composition as claimed in any one of claims 1-2 in the preparation of a medicament for preventing and treating postpartum abdominal pain in dairy cows.
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