TWI740228B - Chinese herbal medicine composition for livestock - Google Patents

Chinese herbal medicine composition for livestock Download PDF

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TWI740228B
TWI740228B TW108136432A TW108136432A TWI740228B TW I740228 B TWI740228 B TW I740228B TW 108136432 A TW108136432 A TW 108136432A TW 108136432 A TW108136432 A TW 108136432A TW I740228 B TWI740228 B TW I740228B
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medicine composition
herbal medicine
animal husbandry
chinese herbal
feed
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TW202114723A (en
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吳忠信
王佩華
王喆宣
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國立臺灣師範大學
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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Abstract

The present invention provides a Chinese herbal medicine composition for livestock, which comprises the following medicinal ingredients in a weight percentage: 5-40% of cinnamon twig, 10-25% of ginseng or codonopsis root, 10-25% of licorice, 10-35% of largehead atractylodes rhozome and 10-25% of dried ginger. The Chinese herbal medicine composition for livestock of the present invention can be used for adding into animal feed to prevent or relieve the respiratory and digestive diseases of livestock animals, and replace the antibiotics used in the livestock industry.

Description

畜牧用中草藥組成物Chinese herbal medicine composition for animal husbandry

本發明係關於一種畜牧用中草藥組成物,特別係用以防治畜牧動物之呼吸系統及消化系統疾病之畜牧用中草藥組成物。The present invention relates to a Chinese herbal medicine composition for animal husbandry, especially a Chinese herbal medicine composition for animal husbandry used to prevent and treat respiratory and digestive system diseases of livestock animals.

畜牧動物健康生長的條件是提供足夠營養、減少疾病產生或傷害等,避免畜牧環境造成動物心理或是生理上的不適感。當畜牧動物感受到生長環境壓力時,常常會造成免疫力下降,產生疾病或死亡。由於台灣位處亞熱帶地區,氣候濕熱而畜牧業多為集約飼養,飼養空間有限,因此常造成畜牧動物容易罹患呼吸系統及消化系統疾病。尤其剛離乳的保育期畜牧動物之抵抗力較弱,更容易發生下痢、呼吸症狀等,甚至因此死亡。The conditions for the healthy growth of livestock animals are to provide adequate nutrition, reduce disease or injury, etc., to avoid the psychological or physical discomfort caused by the livestock environment. When livestock animals feel the pressure of their growth environment, they often cause a decline in immunity, disease or death. Because Taiwan is located in a subtropical region, the climate is hot and humid, and the animal husbandry is mostly intensive breeding, and the breeding space is limited. Therefore, livestock animals are often susceptible to respiratory and digestive diseases. In particular, the resistance of livestock animals in the nursery period that has just been weaned is weaker, and they are more likely to develop diarrhea, respiratory symptoms, and even die as a result.

以台灣飼養的豬隻為例,秋冬季是豬呼吸道疾病的發生期,因天氣變冷,豬隻通常會堆疊取暖,即提高飼養密度,而一旦有疾病發生,傳染的風險也隨之提高。投藥治療雖可降低豬隻的呼吸道或消化道疾病發生率,但當於幼豬適逢成長期,生病即會減緩生長速度,影響發育,進而延長養殖時間。更嚴重的是,若豬隻之間互相傳染,疫情通常不易控制,甚或造成豬隻死亡等損失。Take the pigs raised in Taiwan as an example. Autumn and winter are the occurrence periods of pig respiratory diseases. As the weather becomes cold, pigs are usually stacked for heating, that is, raising the stocking density. Once a disease occurs, the risk of infection also increases. Although drug administration can reduce the incidence of respiratory or digestive tract diseases in pigs, when young pigs are in the growing period, illness will slow down the growth rate, affect development, and extend the breeding time. What's more serious is that if pigs infect each other, the epidemic is usually not easy to control, and it may even cause losses such as pig deaths.

常見有的細菌性疾病包含豬黴漿菌性肺炎(Swine Enzootic Pneumonia, SEP)、豬附紅血球黴漿菌(Eperythrozoonosis, EPY)、豬增生性迴腸炎(Porcine Proliferative Enteropathy)、副豬嗜血桿菌(Haemophilus Parasuis)。Common bacterial diseases include swine enzootic pneumonia (Swine Enzootic Pneumonia, SEP), Eperythrozoonosis (EPY), Porcine Proliferative Enteropathy (Porcine Proliferative Enteropathy), Haemophilus parasuis ( Haemophilus Parasuis).

一般畜牧動物感染疾病時,會使用抗生素進行治療,效果快速有效,但長久使用抗生素除了會有疾病抗藥性,也潛在對人體健康的危害。為了減少抗生素的使用,近期已研發出不少增強畜牧動物抵抗力的方式,多半集中在腸道健康及免疫功能,特別在動物營養範疇,新型飼料添加物之開發如具有特殊功能性之微生物等,乃是目前生物科技研發之主軸;此外,也逐漸開發出防治畜牧動物疾病的中藥複方。然而,大多未能克服療效不彰、用量大、成分複雜及成本高等缺點。Generally, when a livestock animal is infected with a disease, antibiotics are used for treatment, and the effect is fast and effective. However, long-term use of antibiotics will not only cause disease resistance, but also potentially harm human health. In order to reduce the use of antibiotics, many ways to enhance the resistance of livestock animals have been developed recently, mostly focusing on intestinal health and immune function, especially in the field of animal nutrition. The development of new feed additives such as microorganisms with special functions, etc. , Is the main axis of current biotechnology research and development; in addition, Chinese medicine compounds for the prevention and treatment of animal diseases are gradually being developed. However, most of them have failed to overcome the shortcomings of poor efficacy, large dosage, complex ingredients, and high cost.

有鑑於此, 本案發明人認為有必要研發出有效防治畜牧動物疾病之天然中藥複方,改善動物之健康狀態,同時免除畜牧用西藥及抗生素所帶來的負面影響。In view of this, the inventor of this case believes that it is necessary to develop a natural Chinese medicine compound that can effectively prevent and treat animal diseases, improve the health of animals, and at the same time avoid the negative effects of western medicine and antibiotics for animal husbandry.

是以,本發明提供一種畜牧用中草藥組成物,其包含下列重量百分比之藥材成分:桂枝5-40%、人參或黨參10-25%、甘草10-25%、白朮10-35%及乾薑10-25%。Therefore, the present invention provides a Chinese herbal medicine composition for animal husbandry, which contains the following medicinal ingredients in weight percentage: Cassia twig 5-40%, ginseng or Codonopsis 10-25%, licorice 10-25%, Atractylodes macrocephala 10-35% and dried Ginger 10-25%.

進一步地,該藥材成分之型式可為中藥材、濃縮中藥材、中藥材萃取物或其混合物。Further, the type of the medicinal ingredients may be Chinese medicinal materials, concentrated Chinese medicinal materials, Chinese medicinal materials extracts or mixtures thereof.

進一步地,該畜牧用中草藥組成物係一種口服製劑。Further, the Chinese herbal medicine composition for animal husbandry is an oral preparation.

進一步地,該畜牧用中草藥組成物係用於防止或緩解一畜牧動物的呼吸系統及消化系統疾病。Further, the animal husbandry Chinese herbal medicine composition is used to prevent or relieve the respiratory system and digestive system diseases of a livestock animal.

進一步地,該畜牧用中草藥組成物係用於取代畜牧產業使用之西藥或抗生素。Further, the Chinese herbal medicine composition for animal husbandry is used to replace western medicine or antibiotics used in the animal husbandry industry.

進一步地,該畜牧動物為豬。Further, the livestock animal is a pig.

本發明另提供一種如上述之畜牧用中草藥組成物之用途,其係將該畜牧用中草藥組成物用於添加於一飼料中,使該飼料具有重量百分比為0.01-2%之該畜牧用中草藥組成物。The present invention also provides a use of the above-mentioned animal husbandry Chinese herbal medicine composition, which is used for adding the animal husbandry Chinese herbal medicine composition to a feed so that the feed has 0.01-2% by weight of the animal husbandry Chinese herbal medicine composition Things.

進一步地,該飼料具有重量百分比為0.05%之該畜牧用中草藥組成物。Further, the feed has 0.05% by weight of the Chinese herbal medicine composition for animal husbandry.

進一步地,該飼料具有重量百分比為0.1%之該畜牧用中草藥組成物。Further, the feed has 0.1% by weight of the Chinese herbal medicine composition for animal husbandry.

進一步地,該飼料具有重量百分比為0.2%之該畜牧用中草藥組成物。Further, the feed has 0.2% by weight of the Chinese herbal medicine composition for animal husbandry.

本發明另提供一種畜牧用飼料,其包含重量百分比為0.01-2%之上述之畜牧用中草藥組成物。The present invention also provides a feed for animal husbandry, which contains 0.01-2% by weight of the above-mentioned Chinese herbal medicine composition for animal husbandry.

相較於習知技術,本發明之畜牧用中草藥組成物之成分天然單純,可有效防止或緩解畜牧動物之呼吸系統及消化系統疾病,增強動物對不良環境之抵抗力及心血管功能,幫助飼料營養吸收並降低飼養及治療成本,甚至可達到優於使用抗生素的效果,足以取代抗生素。Compared with the conventional technology, the composition of the Chinese herbal medicine composition for animal husbandry of the present invention is natural and simple, which can effectively prevent or alleviate the respiratory and digestive system diseases of livestock animals, enhance the animal’s resistance to adverse environments and cardiovascular functions, and help feed It can absorb nutrients and reduce the cost of feeding and treatment, and can even achieve better effects than the use of antibiotics, which is enough to replace antibiotics.

有關本發明之詳細說明及技術內容,現就配合圖表說明如下。該等圖表並非用以限制本發明之範圍,在此先行敘明。The detailed description and technical content of the present invention are described below in conjunction with the diagrams. These diagrams are not used to limit the scope of the present invention, and are described here first.

本發明揭示一種畜牧用中草藥組成物,其包含下列重量百分比之藥材成分:桂枝5-40%、人參或黨參10-25%、甘草10-25%、白朮10-35%及乾薑 10-25%,較佳為:桂枝10-30%、人參或黨參15-20%、甘草15-20%、白朮15-30%及乾薑 15-20%,更佳為:桂枝25%、人參或黨參18.75 %、甘草18.75%、白朮18.75%及乾薑18.75%,其他具體例如:桂枝5%、人參或黨參25%、甘草25%、白朮30%及乾薑15%;桂枝10%、人參或黨參20%、甘草20%、白朮30%及乾薑20%;桂枝15%、人參或黨參15%、甘草25%、白朮35%及乾薑10%;桂枝20%、人參或黨參15%、甘草15%、白朮30%及乾薑20%;桂枝30%、人參或黨參20%、甘草20%、白朮20%及乾薑10%,且本發明不限於此等。The present invention discloses a Chinese herbal medicine composition for animal husbandry, which contains the following medicinal ingredients in weight percentage: Cassia twig 5-40%, ginseng or Codonopsis 10-25%, licorice 10-25%, Baizhu 10-35% and dried ginger 10- 25%, preferably: Guizhi 10-30%, ginseng or Codonopsis 15-20%, licorice 15-20%, Baizhu 15-30% and dried ginger 15-20%, more preferably: Guizhi 25%, Ginseng or Codonopsis 18.75%, Licorice 18.75%, Atractylodes macrocephala 18.75%, and dried ginger 18.75%, other specific examples: Guizhi 5%, Ginseng or Codonopsis 25%, Licorice 25%, Atractylodes macrocephala 30% and dried ginger 15%; Guizhi 10 %, Ginseng or Codonopsis 20%, Licorice 20%, Atractylodes 30% and Dried Ginger 20%; Guizhi 15%, Ginseng or Codonopsis 15%, Licorice 25%, Atractylodes 35% and Dried Ginger 10%; Guizhi 20%, Ginseng or Codonopsis 15%, Licorice 15%, Baizhu 30%, and Dried Ginger 20%; Guizhi 30%, Ginseng or Dangshen 20%, Licorice 20%, Atractylodes 20% and Dried Ginger 10%, and the present invention is not limited to these .

一般藥材中,桂枝可用於治療風寒感冒或治療心悸等;人參可用於治療氣虛、脾氣不足的倦怠乏力、心悸、失眠或健忘等;甘草可用於治療心氣不足的心動悸、痰多咳嗽、脘腹及四肢攣急作痛、熱毒瘡瘍、咽喉腫痛、食物中毒等;白朮可用於治療脾胃氣虛、運化無力、食少便溏、脘腹脹滿、肢軟神疲、脾虛水停、胎動不安等;乾薑可用於治療脾胃氣虛、脾虛水停、脾虛氣弱等。Among the general medicinal materials, Guizhi can be used to treat colds and colds or treat heart palpitations; ginseng can be used to treat fatigue, palpitations, insomnia, or forgetfulness due to deficiency of qi, spleen deficiency, etc.; licorice can be used to treat heart palpitations, phlegm, cough, and swelling due to insufficient heart-qi. Abdominal and extremity contractures, acute pain, heat toxin sore, sore throat, food poisoning, etc.; Atractylodes macrocephala can be used to treat spleen and stomach qi deficiency, lack of movement and transformation, lack of food, loose stools, fullness of the stomach, soft limbs, fatigue, spleen deficiency and water stagnation, Fetal movement, etc.; dried ginger can be used to treat spleen and stomach qi deficiency, spleen deficiency and water stagnation, spleen deficiency and weak qi.

本發明之畜牧用中草藥組成物亦可視需要地添加其他藥材成分,例如附子、茯苓、蜜丸、川椒,烏梅、黃連、陳皮、當歸、白芍、厚朴、川芎、黃耆、藿香或青皮等,且本發明不限於此等。The animal husbandry Chinese herbal medicine composition of the present invention may also optionally add other medicinal ingredients, such as aconite, poria, honey pill, Sichuan pepper, ebony, coptis, tangerine peel, angelica, white peony, magnolia root, chuanxiong, scutellaria, ageratum or Qingpi etc., and the present invention is not limited to these.

本發明之畜牧用中草藥組成物中,該藥材成分之型式可為中藥材、濃縮中藥材、中藥材萃取物或其混合物。In the animal husbandry Chinese herbal medicine composition of the present invention, the form of the medicinal material component may be a Chinese medicinal material, a concentrated Chinese medicinal material, a Chinese medicinal material extract or a mixture thereof.

本發明中,所述之「中藥材」係源自於自然界得供藥品使用之植物、動物或礦物,經乾燥除去雜質等加工之原藥材或依中醫藥理論進行淨製、切製或炮製以達到臨床的減毒、增效及改變藥性後製成合適秤量與煎藥之中藥飲片,能應用於藥膳或供調劑、調配及製劑使用。基於藥食同源概念,部分中藥材可同時提供食品、健康食品或其他用途使用。In the present invention, the "Chinese medicinal materials" are raw medicinal materials that are derived from plants, animals, or minerals that are used for medicines in nature, and are dried to remove impurities, etc. After achieving clinical attenuation, synergistic effect and changing the medicinal properties, it can be made into suitable weighing and decoction pieces of Chinese medicine, which can be used in medicated diet or for adjustment, blending and preparation. Based on the concept of medicine and food homology, some Chinese medicinal materials can be used for food, health food or other purposes at the same time.

本發明中,所述之「濃縮中藥材」又稱科學中藥,係指將中藥材經水煎煮、濃縮、造粒,再製成顆粒、散、錠、膠囊等不同劑型,以供處方調劑使用者。In the present invention, the "concentrated Chinese medicinal materials" is also called scientific Chinese medicine, which refers to the Chinese medicinal materials are decocted, concentrated and granulated in water, and then made into different dosage forms such as granules, powders, tablets, capsules, etc., for prescription adjustment user.

本發明中,所述之「中藥材萃取物」係利用一些萃取技術將中藥中最大濃度的有效成分提取出,使得中藥製劑的內在質量及臨床治療效果提高,將中藥的效果得以最大限度地發揮者。中藥萃取技術可為溶劑萃取法(例如酒精或水溶劑)、水蒸氣蒸餾法、昇華法、超臨界流體萃取、膜萃取分離技術、超微粉碎技術或中藥絮凝分離技術等,且本發明不限於此等。In the present invention, the "Chinese medicinal material extract" is to use some extraction techniques to extract the maximum concentration of active ingredients in Chinese medicine, so that the intrinsic quality and clinical treatment effect of Chinese medicine preparations are improved, and the effect of Chinese medicine can be maximized. By. Traditional Chinese medicine extraction technology can be solvent extraction (such as alcohol or water solvent), steam distillation, sublimation, supercritical fluid extraction, membrane extraction separation technology, ultra-fine grinding technology or traditional Chinese medicine flocculation separation technology, etc., and the present invention is not limited to And so on.

本發明之畜牧用中草藥組成物係一種口服製劑,用於防止或緩解一畜牧動物的呼吸系統及消化系統疾病。The animal husbandry Chinese herbal medicine composition of the present invention is an oral preparation used to prevent or alleviate the respiratory system and digestive system diseases of a livestock animal.

本發明中,所述之「口服製劑」之形式除了直接將中藥組成物投予給畜牧動物服用外,也可係將中藥組成物與一賦型劑混合成一組成物,或更可依需要加入其他醫藥可接受之載體,例如,膠囊、錠片、乳化劑與液狀懸浮液、分散劑與溶劑。以錠片為例,一般所使用的載體為乳糖、玉米澱粉、潤滑劑、或硬脂酸鎂等。以口服膠囊投藥型式,可以如乳糖與乾燥玉米澱粉等做為有效的稀釋液。此外,可視需要地添加適度的甜味劑、風味劑或是色素。In the present invention, in addition to directly administering the traditional Chinese medicine composition to livestock animals in the form of the "oral preparation", it can also be a combination of the traditional Chinese medicine composition and an excipient to form a composition, or it can be added as needed Other pharmaceutically acceptable carriers, for example, capsules, tablets, emulsifiers and liquid suspensions, dispersions and solvents. Taking tablets as an example, generally used carriers are lactose, corn starch, lubricants, or magnesium stearate. Oral capsule administration type, such as lactose and dried corn starch, etc. can be used as effective diluents. In addition, appropriate sweeteners, flavors, or colorings can be added as needed.

本發明之畜牧用中草藥組成物係用於取代畜牧產業使用之西藥或抗生素。The Chinese herbal medicine composition for animal husbandry of the present invention is used to replace western medicine or antibiotics used in the animal husbandry industry.

本發明中,所述之「畜牧動物」包括豬、牛、羊、馬、騾、驢、駱駝、雞、鴨、鵝、兔等各種禽畜,且本發明並不限於此等;其中,較佳為豬、牛、羊、雞、鴨、鵝,更佳為豬,且最佳為離乳仔豬。In the present invention, the "livestock animals" include pigs, cattle, sheep, horses, mules, donkeys, camels, chickens, ducks, geese, rabbits and other poultry and livestock, and the present invention is not limited to these; among them, more Preferably they are pigs, cattle, sheep, chickens, ducks, and geese, more preferably pigs, and most preferably weaned piglets.

本發明中,所述之「離乳仔豬」係指出生約3至4週,係指剛離乳的仔豬成長至保育豬的豬隻。一般情況下,剛離乳的仔豬的正常個體通常約6至7 kg,而成長至為體重約15至20 kg時,則稱為「保育豬」。豬隻在保育豬時期具備健康體質基礎者可順利進入肉豬階段,較為穩定地成長發育。In the present invention, the "weaning piglet" refers to a piglet that is about 3 to 4 weeks old, and refers to a piglet that has just been weaned and grows to a nursery pig. Under normal circumstances, the normal individual of a newly weaned piglet is usually about 6 to 7 kg, and when it grows to a weight of about 15 to 20 kg, it is called a "care pig". Pigs who have a healthy physical foundation during the nursery period can smoothly enter the hog stage and grow and develop more steadily.

本發明之畜牧用中草藥組成物係用於取代畜牧產業使用之西藥或抗生素,例如治療豬隻下痢或呼吸道疾病的西藥或抗生素(但不限於治療用抗生素及生長用抗生素),本發明並不予以限制。The Chinese herbal medicine composition for animal husbandry of the present invention is used to replace western medicine or antibiotics used in the animal husbandry industry, such as western medicine or antibiotics for the treatment of swine diarrhea or respiratory diseases (but not limited to therapeutic antibiotics and growth antibiotics). limit.

本發明之畜牧用中草藥組成物之用途,係將該畜牧用中草藥組成物用於添加於一飼料中,使該飼料具有重量百分比為0.01至2%之該畜牧用中草藥組成物,具體例如0.01%、0.05%、0.10%、0.2%、0.3%、0.4%、0.5%、0.6%、0.7%、0.8%、0.9%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%或2%;其中,以0.05%、0.1%或0.2%為較佳,0.2%為更佳。The use of the Chinese herbal medicine composition for animal husbandry of the present invention is to add the Chinese herbal medicine composition for animal husbandry to a feed so that the feed has 0.01 to 2% by weight of the Chinese herbal medicine composition for animal husbandry, for example, 0.01% , 0.05%, 0.10%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6 %, 1.7%, 1.8%, 1.9% or 2%; among them, 0.05%, 0.1% or 0.2% is preferred, 0.2% is more preferred.

本發明之畜牧用料,其包含重量百分比為0.01至2%之如上所述之畜牧用中草藥組成物,具體例如0.01%、0.05%、0.10%、0.2%、0.3%、0.4%、0.5%、0.6%、0.7%、0.8%、0.9%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%或2%;其中,以0.05%、0.1%或0.2%為較佳,0.2%為更佳。[ 具體實施例 ] The animal husbandry material of the present invention contains 0.01 to 2% by weight of the above-mentioned animal husbandry Chinese herbal medicine composition, such as 0.01%, 0.05%, 0.10%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9% or 2%; among them, 0.05% , 0.1% or 0.2% is preferred, 0.2% is more preferred. [ Specific Examples ]

以下實施方式不應視為過度地限制本發明。本發明所屬技術領域中具有通常知識者可在不背離本發明之精神或範疇的情況下對本文所討論之實施例進行修改及變化,而仍屬於本發明之範圍。The following embodiments should not be regarded as excessively limiting the present invention. Those with ordinary knowledge in the technical field to which the present invention pertains can make modifications and changes to the embodiments discussed herein without departing from the spirit or scope of the present invention, and still fall within the scope of the present invention.

實施例Example 1-1- 本發明之畜牧用中草藥組成物Chinese herbal medicine composition for animal husbandry of the present invention

配製重量比例為桂枝25%、人參18.75%、甘草18.75%、白朮18.75%及乾薑18.75 %的畜牧用中草藥組成物,以添加於以下實施例2的試驗用飼料中。The animal husbandry Chinese herbal medicine composition was prepared with a weight ratio of 25% cassia twig, 18.75% ginseng, 18.75% licorice, 18.75% Atractylodes macrocephala and 18.75% dried ginger, to be added to the experimental feed of Example 2 below.

實施例Example 2-2- 本發明之畜牧用中草藥組成物Chinese herbal medicine composition for animal husbandry of the present invention 用作離乳仔豬飼料添加劑Used as feed additive for weaning piglets

將120隻約28日齡三品種雜交的離乳仔豬,隨機分配每組30隻的空白組及三個實驗組(0.05%中藥組、0.2%中藥組及0.2%抗生素組):(1) 空白組:飼料不添加任何藥劑;(2) 0.05%中藥組:飼料中添加重量百分比0.05%之實施例1本發明之畜牧用中草藥組成物;(3) 0.2%中藥組:飼料中添加重量百分比0.2%之實施例1本發明之畜牧用中草藥組成物;及(4) 0.2%抗生素組:飼料中添加重量百分比0.2%之抗生素「氨基泰黴素(Tilmicosin)」,此係呼吸道疾病之生長用抗生素。每組豬隻最初平均體重約10 kg,實驗期為六週,飼養至每隻豬隻體重約30 kg,並記錄六週間豬隻生長表現,實驗結果如表1至3及圖1至4所示。本實驗中,「死亡」係指實驗期間六週內死亡的豬隻,「淘汰」係指實驗期間六週內無法成長至體重30 kg的豬隻。120 weaned piglets crossed with three breeds of about 28 days old were randomly assigned to a blank group of 30 and three experimental groups (0.05% Chinese medicine group, 0.2% Chinese medicine group and 0.2% antibiotic group): (1) Blank group : No medicine is added to the feed; (2) 0.05% Chinese medicine group: 0.05% by weight is added to the feed of the Chinese herbal medicine composition for animal husbandry of the present invention; (3) 0.2% Chinese medicine group: 0.2% by weight is added to the feed Example 1 The animal husbandry Chinese herbal medicine composition of the present invention; and (4) 0.2% antibiotic group: 0.2% by weight of the antibiotic "Tilmicosin" is added to the feed, which is an antibiotic for the growth of respiratory diseases. The initial average weight of each group of pigs is about 10 kg, the experimental period is six weeks, and the pigs are raised to a weight of about 30 kg each, and the growth performance of the pigs during the six weeks is recorded. The experimental results are shown in Tables 1 to 3 and Figures 1 to 4. Show. In this experiment, "death" refers to pigs that died within six weeks of the experiment, and "eliminated" refers to pigs that were unable to grow to a body weight of 30 kg within six weeks of the experiment.

表1.生長性狀   空白組 0.05% 中藥組 0.2% 中藥組 0.2% 抗生素組 起始體重 10.31 ± 0.40 (n=31) 10.63 ± 0.35 (n=32) 11.19 ± 0.29 (n=32) 10.93 ± 0.36 (n=31) 前期 -2 週後體重 12.99 ± 0.48 (n=29) 14.04 ± 0.53 (n=29) 15.72 ± 0.47 (n=31) 15.54 ± 0.50 (n=30) 中期 -4 週後體重 18.34 ± 0.72 (n=25) 20.80 ± 0.73 (n=25) 22.13 ± 0.65 (n=29) 22.71 ± 0.75 (n=26) 後期 -6 週後體重 27.45 ± 1.07 (n=22) 29.63 ± 0.97 (n=25) 30.97 ± 0.93 (n=29) 30.92 ± 0.95 (n=26) 0-2 週增重 2.81 ± 0.33 (n=29) 3.30 ± 0.27 (n=29) 4.52 ± 0.28 (n=31) 4.51 ± 0.29 (n=30) 2-4 週增重 5.22 ± 0.42 (n=25) 6.33 ± 0.30 (n=25) 6.07 ± 0.43 (n=29) 6.82 ± 0.40 (n=26) 4-6 週增重 8.51 ± 0.53 (n=22) 8.82 ± 0.44 (n=25) 8.84 ± 0.45 (n=29) 8.22 ± 0.36 (n=26) 0-6 週增重 17.45 ± 0.94 (n=22) 18.78 ± 0.76 (n=25) 19.61 ± 0.86 (n=29) 19.88 ± 0.75 (n=26) 0-2 週日平均增重 0.201 ± 0.024 (n=29) 0.236 ± 0.019 (n=29) 0.323 ± 0.020 (n=31) 0.322 ± 0.021 (n=30) 0-4 週日平均增重 0.294 ± 0.023 (n=25) 0.355 ± 0.016 (n=25) 0.385 ± 0.020 (n=29) 0.416 ± 0.019 (n=26) 0-6 週日平均增重 0.415 ± 0.022 (n=22) 0.447 ± 0.018 (n=25) 0.467 ± 0.020 (n=29) 0.473 ± 0.018 (n=26) 體重單位:kg;n:仔豬數量Table 1. Growth traits Blank group 0.05% Chinese medicine group 0.2% Chinese medicine group 0.2% antibiotic group Starting weight 10.31 ± 0.40 (n=31) 10.63 ± 0.35 (n=32) 11.19 ± 0.29 (n=32) 10.93 ± 0.36 (n=31) Weight in the first period -2 weeks later 12.99 ± 0.48 (n=29) 14.04 ± 0.53 (n=29) 15.72 ± 0.47 (n=31) 15.54 ± 0.50 (n=30) Mid-term - weight after 4 weeks 18.34 ± 0.72 (n=25) 20.80 ± 0.73 (n=25) 22.13 ± 0.65 (n=29) 22.71 ± 0.75 (n=26) Late- 6 weeks weight 27.45 ± 1.07 (n=22) 29.63 ± 0.97 (n=25) 30.97 ± 0.93 (n=29) 30.92 ± 0.95 (n=26) 0-2 weeks weight gain 2.81 ± 0.33 (n=29) 3.30 ± 0.27 (n=29) 4.52 ± 0.28 (n=31) 4.51 ± 0.29 (n=30) Weight gain in 2-4 weeks 5.22 ± 0.42 (n=25) 6.33 ± 0.30 (n=25) 6.07 ± 0.43 (n=29) 6.82 ± 0.40 (n=26) Weight gain in 4-6 weeks 8.51 ± 0.53 (n=22) 8.82 ± 0.44 (n=25) 8.84 ± 0.45 (n=29) 8.22 ± 0.36 (n=26) 0-6 weeks weight gain 17.45 ± 0.94 (n=22) 18.78 ± 0.76 (n=25) 19.61 ± 0.86 (n=29) 19.88 ± 0.75 (n=26) 0-2 Average weight gain on Sunday 0.201 ± 0.024 (n=29) 0.236 ± 0.019 (n=29) 0.323 ± 0.020 (n=31) 0.322 ± 0.021 (n=30) 0-4 Average weight gain on Sunday 0.294 ± 0.023 (n=25) 0.355 ± 0.016 (n=25) 0.385 ± 0.020 (n=29) 0.416 ± 0.019 (n=26) 0-6 average weight gain on weekdays 0.415 ± 0.022 (n=22) 0.447 ± 0.018 (n=25) 0.467 ± 0.020 (n=29) 0.473 ± 0.018 (n=26) Weight unit: kg; n: number of piglets

表2. 死亡及淘汰數   空白組 0.05% 中藥組 0.2% 中藥組 0.2% 抗生素組 死亡 3 2 3 2 淘汰 6 5 0 3 Table 2. Number of deaths and eliminations Blank group 0.05% Chinese medicine group 0.2% Chinese medicine group 0.2% antibiotic group die 3 2 3 2 disuse 6 5 0 3

表3. 疾病發生率   空白組 0.05% 中藥組 0.2% 中藥組 0.2% 抗生素組   下痢隻數 0.27 ± 0.71 0.41 ± 0.92 0.15 ± 0.48 0.78 ± 1.42 每日下痢發生率 (%) 0.98 ± 2.42 1.54 ± 3.49 0.48 ± 1.58 2.83 ± 5.26 呼吸症狀隻數 2.76 ± 1.73 3.05 ± 2.17 1.73 ± 1.32 1.54 ± 1.63 每日呼吸症狀發生率 (%) 10.45 ± 6.29 10.98 ± 7.29 5.65 ± 4.23 5.28 ± 5.45 Table 3. Disease incidence Blank group 0.05% Chinese medicine group 0.2% Chinese medicine group 0.2% antibiotic group Number of diarrhea 0.27 ± 0.71 0.41 ± 0.92 0.15 ± 0.48 0.78 ± 1.42 Daily incidence of diarrhea (%) 0.98 ± 2.42 1.54 ± 3.49 0.48 ± 1.58 2.83 ± 5.26 Respiratory symptoms only 2.76 ± 1.73 3.05 ± 2.17 1.73 ± 1.32 1.54 ± 1.63 Daily incidence of respiratory symptoms (%) 10.45 ± 6.29 10.98 ± 7.29 5.65 ± 4.23 5.28 ± 5.45

請參閱表1及圖1,0.2%中藥組及0.2%抗生素組的豬隻的體重增加最多,其次為0.05%中藥組,最後為空白組,顯見本發明之畜牧用中草藥組成物以重量百分比0.2%添加於飼料,可達到與使用0.2%氨基泰黴素之抗生素組相同的成長狀況。Please refer to Table 1 and Figure 1. The pigs in the 0.2% Chinese medicine group and 0.2% antibiotic group gained the most weight, followed by the 0.05% Chinese medicine group, and finally the blank group. It is obvious that the animal husbandry Chinese herbal medicine composition of the present invention has a weight percentage of 0.2 % Added to feed, it can achieve the same growth condition as the antibiotic group using 0.2% aminotaimycin.

請參閱表2及圖2,無論是死亡或淘汰,空白組的豬隻皆為最多,隨依序為0.05%中藥組、0.2%抗生素組、0.2%中藥組。其中,0.2%中藥組並無死亡豬隻,只有3隻淘汰豬隻。此外,如圖3所示,0.2%中藥組的育成率為最高,隨後依序為0.2%抗生素組、0.05中藥組及空白組。由此可知,本發明之畜牧用中草藥組成物可有效降低豬隻患病及死亡的機率,提升育成率,使得豬隻在更佳體質基礎之上持續成長,且足以取代抗生素。Please refer to Table 2 and Figure 2. Regardless of whether it is dead or eliminated, the blank group has the most pigs, followed by 0.05% Chinese medicine group, 0.2% antibiotic group, and 0.2% Chinese medicine group. Among them, there were no dead pigs in the 0.2% Chinese medicine group, and only 3 culled pigs. In addition, as shown in Figure 3, the 0.2% Chinese medicine group had the highest breeding rate, followed by the 0.2% antibiotic group, the 0.05 Chinese medicine group, and the blank group. It can be seen that the animal husbandry Chinese herbal medicine composition of the present invention can effectively reduce the probability of disease and death of pigs, increase the breeding rate, and enable pigs to continue to grow on the basis of better physical fitness, and is sufficient to replace antibiotics.

請參閱表3及圖4,每日下痢發生率最低為0.2%中藥組,隨後依序升高為空白組、0.05%中藥組及0.2%抗生素組,顯見由於0.2%抗生素組由於係投予呼吸道疾病之生長用抗生素,而無法有效控制下痢發生率。每日呼吸症狀發生率則係0.2%中藥組及0.2%抗生素組結果為相近,分別僅有5.65%及5.25%,顯見0.2%中藥組對呼吸症發生的控制可達到同0.2%抗生素組相同效果。綜觀兩項疾病發生率可知,相較於抗生素組僅能提供降低呼吸道症狀發生率但無法降低下痢發生率,本發明之畜牧用中草藥組成物則能有效預防或治療豬隻消化系統及呼吸系統疾病,即可作為替代抗生素或西藥的良方。Please refer to Table 3 and Figure 4. The daily incidence of diarrhea was the lowest in the 0.2% Chinese medicine group, and then increased to the blank group, 0.05% Chinese medicine group, and 0.2% antibiotic group. Obviously, the 0.2% antibiotic group was administered to the respiratory tract. Antibiotics are used for the growth of the disease, but the incidence of diarrhea cannot be effectively controlled. The incidence of daily respiratory symptoms was similar in the 0.2% Chinese medicine group and the 0.2% antibiotic group, with only 5.65% and 5.25% respectively. It is obvious that the 0.2% Chinese medicine group can achieve the same effect as the 0.2% antibiotic group in controlling the occurrence of respiratory symptoms. . Looking at the incidence of the two diseases, it can be seen that compared to the antibiotic group, which can only reduce the incidence of respiratory symptoms but not the incidence of diarrhea, the Chinese herbal medicine composition for animal husbandry of the present invention can effectively prevent or treat pig digestive and respiratory diseases , Can be used as a good alternative to antibiotics or western medicine.

綜上所述,本發明之畜牧用中草藥組成物之成分天然單純,可有效防止或緩解畜牧動物之呼吸系統及消化系統疾病,增強動物對不良環境之抵抗力及心血管功能,幫助飼料營養吸收並降低飼養及治療成本,且本發明之畜牧用中草藥組成物甚至可達到優於使用抗生素的效果,足以取代抗生素。In summary, the composition of the Chinese herbal medicine composition for animal husbandry of the present invention is natural and simple, which can effectively prevent or alleviate the respiratory and digestive system diseases of livestock animals, enhance the animal’s resistance to adverse environments and cardiovascular functions, and help feed nutrition absorption And reduce the cost of feeding and treatment, and the Chinese herbal medicine composition for animal husbandry of the present invention can even achieve better effects than the use of antibiotics, which is sufficient to replace antibiotics.

以上已將本發明做一詳細說明,惟以上所述者,僅為本發明之一較佳實施例而已,當不能以此限定本發明實施之範圍,即凡依本發明申請專利範圍所作之均等變化與修飾,皆應仍屬本發明之專利涵蓋範圍內。The present invention has been described in detail above, but what is described above is only a preferred embodiment of the present invention, and should not be used to limit the scope of implementation of the present invention, that is, everything made in accordance with the scope of the patent application of the present invention is equal Changes and modifications should still fall within the scope of the patent of the present invention.

圖1係實施例2豬隻生長體重增加效果之雷達圖。Fig. 1 is a radar chart of the growth and weight gain effect of pigs in Example 2.

圖2係實施例2豬隻淘汰及死亡比例之柱狀圖。Figure 2 is a histogram of the proportion of pigs culled and died in Example 2.

圖3係實施例2豬隻育成率之曲線圖。Figure 3 is a graph showing the breeding rate of pigs in Example 2.

圖4係實施例2豬隻每日疾病發生率之柱狀圖。Figure 4 is a histogram of the daily disease incidence of pigs in Example 2.

Claims (10)

一種畜牧用飼料,其包含重量百分比為0.01-2%之中草藥組成物,該中草藥組成物係由下列重量百分比之藥材成分所組成:桂枝5-40%、人參或黨參10-25%、甘草10-25%、白朮10-35%及乾薑10-25%。 A feed for animal husbandry, comprising 0.01-2% by weight Chinese herbal medicine composition, the Chinese herbal medicine composition is composed of the following medicinal components by weight: Cassia twig 5-40%, ginseng or Codonopsis 10-25%, licorice 10-25%, Baizhu 10-35% and dried ginger 10-25%. 如請求項1所述之畜牧用飼料,其中該藥材成分之型式可為中藥材、濃縮中藥材、中藥材萃取物或其混合物。 The animal husbandry feed according to claim 1, wherein the form of the medicinal material component may be Chinese medicinal materials, concentrated Chinese medicinal materials, Chinese medicinal materials extracts or mixtures thereof. 如請求項1所述之畜牧用飼料,其係一種口服製劑。 The animal husbandry feed as described in claim 1, which is an oral preparation. 如請求項1所述之畜牧用飼料,其係用於防止或緩解一畜牧動物的呼吸系統及消化系統疾病。 The livestock feed as described in claim 1, which is used to prevent or alleviate the respiratory and digestive system diseases of a livestock animal. 如請求項4所述之畜牧用飼料,其係用於取代畜牧產業使用之西藥或抗生素。 The feed for animal husbandry as described in claim 4, which is used to replace western medicine or antibiotics used in the animal husbandry industry. 如請求項4或5所述之畜牧用飼料,其中該畜牧動物為豬。 The livestock feed according to claim 4 or 5, wherein the livestock animal is a pig. 一種畜牧用中草藥組成物之用途,其係將一畜牧用中草藥組成物用於添加於一飼料中,使該飼料具有重量百分比為0.01-2%之該畜牧用中草藥組成物,其中,該畜牧用中草藥組成物係由下列重量百分比之藥材成分所組成:桂枝5-40%、人參或黨參10-25%、甘草10-25%、白朮10-35%及乾薑10-25%。 A use of a Chinese herbal medicine composition for animal husbandry, which is to add a Chinese herbal medicine composition for animal husbandry to a feed so that the feed has 0.01-2% by weight of the Chinese herbal medicine composition for animal husbandry. The Chinese herbal medicine composition is composed of the following medicinal ingredients in weight percentages: Cassia twig 5-40%, ginseng or Codonopsis 10-25%, licorice 10-25%, Atractylodes macrocephala 10-35% and dried ginger 10-25%. 如請求項7所述之用途,其中該飼料具有重量百分比為0.05%之該畜牧用中草藥組成物。 The use according to claim 7, wherein the feed has 0.05% by weight of the Chinese herbal medicine composition for animal husbandry. 如請求項7所述之用途,其中該飼料具有重量百分比為0.1%之該畜牧用中草藥組成物。 The use according to claim 7, wherein the feed has 0.1% by weight of the Chinese herbal medicine composition for animal husbandry. 如請求項7所述之用途,其中該飼料具有重量百分比為0.2%之該畜牧用中草藥組成物。 The use according to claim 7, wherein the feed has 0.2% by weight of the Chinese herbal medicine composition for animal husbandry.
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醫砭 常用方劑 (869方) 方名 桂枝人參湯 來源 傷寒卒病論 http://yibian.hopto.org/fang/?fno=285 *

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