CN103432543B - A kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows and preparation method thereof - Google Patents
A kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows, effectively can promote Uterine And Cervical Involution In The Cow, the weight proportion of this Chinese medicine composition Raw medicine is: Radix Angelicae Sinensis 20-50 part, Rhizoma Chuanxiong 15-45 part, Semen Persicae 15-40 part, Rhizoma Zingiberis 10-35 part, Herba Artemisiae Anomalae 18-45 part, Radix Paeoniae Alba 15-50 part, Rhizoma Cyperi 15-45 part, Fructus Crataegi 30-65 part, Massa Medicata Fermentata 45-90 part, Fructus Hordei Germinatus 25-65 part.Chinese medicine composition of the present invention bestows the pathophysiological condition of calving cow scalable fresh cow multiple deficiency and stasis in puerperal in 2h, improve himself phylactic power defensive power, effective prevention placenta retention in puerperal, lochia, promote that lochia drains, purification intrauterine environment, promotes the involution of uterus simultaneously, recover its normal physiological function, thus improve the fertility performance of milch cow.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows.
Background technology
Take milk yield as the breeding selection-breeding of guiding, through genetic improvement for many years with preferred, the milk yield of milch cow improves year by year, and modern dairy bread is more responsive to environment, reduces the resistance of disease, easily hysteropathy in puerperal occurs.And puerperal hysteropathy, be one of principal element affecting milk cow production performance, the fertility performance therefore how improving milch cow is that current milch cow develops the new challenge faced.Calving interval is one of important indicator evaluating cow reproduction efficiency, and the calving interval is longer, means that feeding cost is higher.Although it is apparent unlike Other diseases that the calving interval extends its clinical harm, cow reproduction benefit is had to the impact of potentiality, have a strong impact on cattle farm economic benefit.
Affect a lot of because have of calving interval, wherein the speed of the involution of uterus and degree, post-partum estrus breeding and time of becoming pregnant are the most direct factors extending the calving interval.The involution of uterus refers to that puerperal is through volume-diminished, tissue degradation and endometrial epithelium tissue repair, and recover of uterus is to the physiological process of state during unpregnancy and function.Cow involution of uterus of puerperal is an important research category in obstetrics.The speed of Uterine And Cervical Involution In The Cow and degree, directly affect the post-partum estrus of milch cow, breed and become pregnant, and is the principal element determining milch cow fertility in puerperal quality.As important economic animal, the meaning of involution of uterus of puerperal dairy cows is important more than other domestic animal, Postpartum Cows uterus returns to normal physiological function as early as possible, and the benefit for the stability development and cattle farm that maintain milk cow production performance has very important practice significance and economic benefit.
At present, existing research shows, by using hormone, as estrogen, progestogen, promoting sexual gland hormone, GnRH, prostaglandin and oxytocin etc., to accelerating the speed of involution of uterus of puerperal dairy cows, does not get a desired effect.Secondly the utilization of these medicines, also can cause hormone residues, finally affects the health of the mankind.And Chinese medicine has rich experience in puerperal disease is prevented and treated.Milch cow placenta retention in puerperal, blood stasis uterus, or damage uterus because of practise midwifery and when peeling off and be detained afterbirth, or milch cow has a delicate constitution, QI and blood is thanks to two, loses puerperal in nursing, has a cold caused by invasion and attack, blood stagnation, all can delay the involution of uterus or cause subinvolution of uterus.Chinese veterinarian's pharmacy, from this Pathophysiology feature of multiple deficiency and stasis in puerperal, adopts the therapy of righting, blood stasis dispelling, effectively can improve the recovery of producing poultry self-defense power and accelerating physiological function, thus it is healthy to maintain puerperal.
Along with dairy industry in China develop rapidly and compatriots to the raising of high-quality milk product demand, how effectively carrying out the Developing Application of the Chinese medicine preparation of dairy stock puerperal disease control, promote the lasting sane development of milk industry, is the important topic of Chinese veterinarian's medicine development.Chinese invention patent application CN 102133307 A discloses the medicine for the treatment of subinvolution of uterus, but it lays particular emphasis on the therapeutical effect of subinvolution of uterus and endometritis.And for milch cow, subinvolution of uterus or the involution of uterus slow down all will have a strong impact on milk cow production performance, deal with improperly and milch cow even can be caused infertile throughout one's life, shorten milch cow service life, add mortality, bring the heavy losses for the treatment of cost and economic interests.Adopt Chinese herb prevention to combine aggregate measures such as strengthening feeding and management, prevent trouble before it happens, namely the preventive treatment of disease of the traditional Chinese medical science is this.
Summary of the invention
The invention provides a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows, effectively can promote Uterine And Cervical Involution In The Cow, for this reason, the present invention also provides the preparation method of this Chinese medicine composition.
A kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows provided by the invention, the weight proportion of described Chinese medicine composition Raw medicine is: Radix Angelicae Sinensis 20 – 50 parts, Rhizoma Chuanxiong 15 – 45 parts, Semen Persicae 15 – 40 parts, Rhizoma Zingiberis 10 – 35 parts, Herba Artemisiae Anomalae 18 – 45 parts, the Radix Paeoniae Alba 15 – 50 parts, Rhizoma Cyperi 15 – 45 parts, Fructus Crataegi 30 – 65 parts, Massa Medicata Fermentata 45 – 90 parts, Fructus Hordei Germinatus 25 – 65 parts.
Further, the weight proportion of described Chinese medicine composition Raw medicine is: Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 25 parts, 25 parts, Semen Persicae, Rhizoma Zingiberis 15 parts, Herba Artemisiae Anomalae 30 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 50 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
The best results of the promotion involution of uterus of puerperal dairy cows of Chinese medicine composition under this formula.
Further, pharmaceutically acceptable adjuvant is also comprised.
Further, the dosage form of described Chinese medicine composition is the molten Chinese medicine granules of alcohol.
Second object of the present invention is to provide a kind of medicine, comprise crude drug and pharmaceutically acceptable adjuvant, the weight proportion of described crude drug is: Radix Angelicae Sinensis 20 – 50 parts, Rhizoma Chuanxiong 15 – 45 parts, Semen Persicae 15 – 40 parts, Rhizoma Zingiberis 10 – 35 parts, Herba Artemisiae Anomalae 18 – 45 parts, the Radix Paeoniae Alba 15 – 50 parts, Rhizoma Cyperi 15 – 45 parts, Fructus Crataegi 30 – 65 parts, Massa Medicata Fermentata 45 – 90 parts, Fructus Hordei Germinatus 25 – 65 parts.
Preferably, the weight proportion of described crude drug is: Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 25 parts, 25 parts, Semen Persicae, Rhizoma Zingiberis 15 parts, Herba Artemisiae Anomalae 30 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 50 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
3rd object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition, and be the crude drug mixing of getting formula ratio, adding mass percent is 50% ethanol, carry out reflux, extract, ethanol is reclaimed in heating pressurization, is concentrated into paste, add adjuvant, wet granulation after mix homogeneously, dry.
Further, the addition of described ethanol is 5 – 10 times of crude drug weight.
Further, ethanol is reclaimed in described heating pressurization is reclaim ethanol under the condition of 40-60 DEG C, 0.06-0.08MPa.
4th object of the present invention is to provide the application of above-mentioned Chinese medicine composition in the medicine of preparation promotion involution of uterus of puerperal dairy cows.
The present invention is the Pathophysiology feature according to fresh cow multiple deficiency and stasis, under the reason of traditional Chinese veterinary medicine, method, side and medicine theoretical direction, and uses for reference the modern study achievement of involution of uterus mechanism, selects plurality of Chinese to carry out prescription.In pharmaceutical composition of the present invention, Radix Angelicae Sinensis, Rhizoma Chuanxiong, enrich blood and invigorate blood circulation, circulation of qi promoting; Semen Persicae, removing blood stasis with potent drugs blood, pain relieving, stimulates the menstrual flow; Rhizoma Cyperi, promoting the circulation of QI to relieve pain; Rhizoma Zingiberis, the Radix Paeoniae Alba, warming middle-JIAO is supporing yang, and hemostasis, nourishes blood; Herba Leonuri, Herba Artemisiae Anomalae, blood circulation promoting and blood stasis dispelling, pain relieving; Fructus Crataegi, Massa Medicata Fermentata, spleen invigorating and in; Fructus Hordei Germinatus, lactogenesis.All medicine compatibilities, have blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the effect of training tonifying the spleen and stomach and QI and blood.Chinese medicine composition of the present invention bestows the pathophysiological condition of calving cow scalable fresh cow multiple deficiency and stasis in puerperal in 2h, improve himself phylactic power defensive power, effective prevention placenta retention in puerperal, lochia, promote that lochia drains, purification intrauterine environment, promotes the involution of uterus simultaneously, recover its normal physiological function, thus improve the fertility performance of milch cow.
Detailed description of the invention
Explain the present invention in detail hereafter by concrete preparation example and test example, but following examples case being descriptive, is not determinate, can not limit protection scope of the present invention with this.In an embodiment, term " part " refers to weight portion.
embodiment 1
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 25 parts, 25 parts, Semen Persicae, Rhizoma Zingiberis 15 parts, Herba Artemisiae Anomalae 30 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 50 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
preparation methodadopt Effect of Alcohol Extracting Procedureto Total, each formula is removed impurity, after following an example to do, takes medical material in prescription ratio, pulverize, add 50% ethanol of medical material weight 7 times amount, reflux, extract, 2 times, merge extractive liquid, 40 DEG C, under 0.08MPa pressure condition, after reclaiming ethanol, be concentrated into paste, the ratio of thick paste, dextrin and calcium gluconate is 1:1:2, dextrin and calcium gluconate are added in thick paste and makes soft material, cross 16 mesh sieves and granulate, dry, granulate, obtains (1g is equivalent to primary crude drug 3g), is granule.
embodiment 2
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 15 parts, 40 parts, Semen Persicae, Rhizoma Zingiberis 10 parts, Herba Artemisiae Anomalae 45 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi 15 parts, Fructus Crataegi 30 parts, Massa Medicata Fermentata 45 parts and Fructus Hordei Germinatus 65 parts.
preparation methodadopt Effect of Alcohol Extracting Procedureto Total, each formula is removed impurity, after following an example to do, take medical material in prescription ratio, pulverize, add 50% ethanol of medical material weight 5 times amount, reflux, extract, 3 times, merge extractive liquid, 50 DEG C, under 0.06MPa pressure condition, after reclaiming ethanol, be concentrated into paste, the ratio of thick paste, dextrin and calcium gluconate is 1:1:2, dextrin and calcium gluconate are added in thick paste and makes soft material, cross 16 mesh sieves to granulate, dry, granulate, obtaining (1g is equivalent to primary crude drug 3g), is granule.
embodiment 3
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 50 parts, Rhizoma Chuanxiong 15 parts, 40 parts, Semen Persicae, Rhizoma Zingiberis 35 parts, Herba Artemisiae Anomalae 18 parts, the Radix Paeoniae Alba 50 parts, Rhizoma Cyperi 15 parts, Fructus Crataegi 30 parts, Massa Medicata Fermentata 45 parts and Fructus Hordei Germinatus 40 parts.
preparation methodadopt Effect of Alcohol Extracting Procedureto Total, each formula is removed impurity, after following an example to do, take medical material in prescription ratio, pulverize, add 50% ethanol of medical material weight 10 times amount, reflux, extract, 1 time, collects backflow medicinal liquid, 60 DEG C, under 0.07MPa pressure condition, after reclaiming ethanol, be concentrated into paste, the ratio of thick paste, dextrin and calcium gluconate is 1:1:2, dextrin and calcium gluconate are added in thick paste and makes soft material, cross 16 mesh sieves to granulate, dry, granulate, obtaining (1g is equivalent to primary crude drug 3g), is granule.
embodiment 4
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 50 parts, Rhizoma Chuanxiong 15 parts, 40 parts, Semen Persicae, Rhizoma Zingiberis 35 parts, Herba Artemisiae Anomalae 45 parts, the Radix Paeoniae Alba 50 parts, Rhizoma Cyperi 45 parts, Fructus Crataegi 30 parts, Massa Medicata Fermentata 90 parts and Fructus Hordei Germinatus 40 parts.
The preparation method of the present embodiment is in the same manner as in Example 1.
embodiment 5
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 45 parts, 40 parts, Semen Persicae, Rhizoma Zingiberis 10 parts, Herba Artemisiae Anomalae 45 parts, the Radix Paeoniae Alba 50 parts, Rhizoma Cyperi 45 parts, Fructus Crataegi 65 parts, Massa Medicata Fermentata 45 parts and Fructus Hordei Germinatus 40 parts.
The preparation method of the present embodiment is in the same manner as in Example 2.
embodiment 6
1. the formula of Chinese medicine composition of the present invention is:radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 15 parts, 40 parts, Semen Persicae, Rhizoma Zingiberis 30 parts, Herba Artemisiae Anomalae 20 parts, the Radix Paeoniae Alba 50 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 65 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
The preparation method of the present embodiment is in the same manner as in Example 3.
embodiment 7
Lower routine test example proves that Chinese medicine composition of the present invention has excellent prevention effect to involution of uterus of puerperal dairy cows, lochia.
preclinical safety evaluation
1.1 objectcarry out acute toxicity test, to evaluate the safety of Chinese medicine composition clinical application of the present invention.
test methodby 50 white mice after laboratory rearing 3d, be divided into 5 groups, often organize 10, male and female half and half.Fasting 8h(can't help water) after, by geometric ratio coefficient 1.4 administration, namely respectively by 14.0000 g/kg, 19.6000g/kg, 27.4400 g/kg, 38.4160 g/kg and 53.7824 g/kg, 5 dosage groups, by the non-isoconcentration gastric infusion of the capacity such as body weight, each dosage≤0.8 mL, point 1-3 administration (high dose needs 3 administrations) within 24h.To the spirit of observation post administration white mice, behavior, diet for situations such as performance and death, analyse dead white mice in time, observe the pathological change of its main organs, altogether 7d.Dissect by medicine mice during off-test, observe and record the change of each internal organs of test mice.Add up dead mice number, calculate its LD by improvement karber's method
50and 95% fiducial limit.
resultlow dose group no abnormality seen performance after white mice perfusion, spirit is still good, movable as usual.High dose group is after the 3rd administration, quiet and few dynamic, the no abnormality seens such as breathing.Within 2nd day, start to occur death, cut open inspection pathological change mainly at small intestinal, be congested or hemorrhage change, other organs has no observes pathological changes.Within 7d, 5 groups respectively dead 0,2,5,8 with 10.Refer to table 1.
。
Its LD is calculated by improvement karber's method
50and LD
5095% fiducial limit.LD
50for 27.44g/kg.bw, LD
5095% be crediblely limited to 23.121-32.566g/kg.bw.
1.4 brief summaryin the present invention, Chinese medicine composition is to the per os LD of mice
50be greater than 15g/kg.bw, according to exogenous polyamines acute toxicity grading criteria (Canadian Centre for Occupational Health and Safety), be considered as actual avirulence, clinical drug safety is reliable.
2. Clinical Treatment Test
2.1 cows are selectedduring in March, 2008 to 2012 year JIUYUE, select Lanzhou, the calving cow of silver and Deng Di cattle farm, Ningxia is this experimental study object, selected milch cow is healthy in the pregnancy period, 2-7 parity, do not inoculate brucellin, and Brucella is detected as feminine gender, according to milch cow body condition standards of grading, during calving, its Body Condition Score is between 3.0 ~ 4.0.According to ear tag numeral, test Niu Suiji is divided into two groups, odd number person is present composition prophylactic treatment group, and even number person is matched group, and as there is placenta retention or hysteropathy, cattle farm veterinary according to circumstances takes corresponding treatment measure.
test medication and methodchinese medicinal composition granules 100g of the present invention is dissolved in 500ml yellow wine, gavages administration, or share with brown sugar, wheat bran, and boiled water soaks, Hou Wen, and puerperal, about 2h bestowed Postpartum Cows from drink.Once a day, 3 days are used in conjunction.Observe in process of the test and record milch cow spirit, situation discharged by appetite, afterbirth and the fertility performance index in tested milch cow puerperal, comprises the postpartum heat time, Breeding times, the conceived time.
evaluating drug effect indexretained afterbirth in puerperal rate, lochia discharges situation and reproductive performance in 180 days puerperal, comprises the postpartum heat time, conception rate, pregnancy rate of once oestrusing, nonpregnant time and general fertility rate.The wherein criterion of placenta retention: puerperal, 12h afterbirth did not descend person, was judged to be retained afterbirth.
data statisticsutilize SPSS
?(Version 17.0) carries out data analysis.Utilize conception rate between each group of Variance Analysis Evaluation, the diversity of once inseminate pregnancy rate and total fertility rate; Utilize the diversity of estrus time first time between each group of U-test checking and appraising and nonpregnant time, represent with median and quartile interval.P< 0.05 is significant difference.
result
Duration of test has 2360 cow head calving, according to judgment criteria and the exclusion standard of the test milch cow of this experiment, final Chinese medicine composition prophylactic treatment group of the present invention and matched group have the interpretation of result of therapeutic outcome for this test of 1150 and 1090 test milch cows respectively.Duration of test does not find to bring obvious negative effect to by medicine milch cow.
on the impact that afterbirth is discharged
According to test medication, puerperal, about 2h gave Chinese medicine composition of the present invention, once a day, continuous three days, prophylactic treatment group had 45 cow head generation placenta retention, the incidence rate of placenta retention is 3.9%, and matched group has 235 cow head generation placenta retention, the incidence rate of placenta retention is 21.6%, and difference is extremely remarkable, p<0.01, result shows that the present composition effectively can prevent the generation of milch cow placenta retention in puerperal.Secondly, the afterbirth for the treatment of group of the present invention does not descend cattle, and when without human intervention, generally independently can discharge afterbirth 3-5 days puerperal, afterbirth is complete, but afterbirth color is crineous; Duration of test present composition prophylactic treatment group has 7 cattle, be take tetramycin hydrochloride uterus topical to carry out processing cattle farm veterinary and carry out peel manually from delay afterbirth.
on the impact that lochia is discharged
Observe Chinese medicine composition of the present invention to the time effects of milch cow lochia emptying, only the tested milch cow of 2 cattle farms carries out wherein, and Chinese medicine composition prophylactic treatment group of the present invention has 96, and matched group has 75 cow heads.Prophylactic treatment group is according to test medication, puerperal 2h give Chinese medicine composition of the present invention, once a day, continuous three days, thin out gradually with the color of lochia, bad smell alleviates as index judges gradually, the lochia of matched group milch cow drained the time between 12.5-18.0 days, and the milch cow of Chinese medicine composition prophylactic treatment group of the present invention is after treatment 3-4 days, rectum touches and detects, the uterine contraction rhythm and pace of moving things is normal, and within the 6th day, start intrauterine and discharge limpid mucus, lochia drains the time then between 9.5-14.5 days.Result of the test shows, Chinese medicine composition of the present invention puerperal about 2h bestow and can promote draining of milch cow lochia, effectively purification intrauterine environment in puerperal.
chinese medicine composition of the present invention is on the impact of fertility performance in puerperal
Chinese medicine composition of the present invention is on milch cow productive impact in puerperal, in table 2, compare with normal group milch cow, Chinese medicine composition of the present invention can significantly improve the fertility performance by medicine milch cow, be mainly manifested in, improve milch cow conception rate (p=0.044), first service pregnancy rate (p=0.075), by the total fertility rate (p<0.01) of medicine milch cow in 180 days.In addition, in Chinese medicine composition prophylactic treatment group of the present invention, the tire pregnancy rate of awarding by medicine milch cow is 100%.Compare with matched group milch cow, Chinese medicine composition of the present invention obviously can shorten estrus time puerperal to first time and nonpregnant time.Result shows, Chinese medicine composition of the present invention effectively can improve the fertility performance of puerperal by medicine milch cow.From by the medicine milch cow nonpregnant time in puerperal effectively shorten with 90 days in milch cow pregnancy rate significantly raise, can infer that Chinese medicine composition 2h in puerperal of the present invention bestows and effectively can promote involution of uterus of puerperal dairy cows.
。
A p<0.05, significant difference; B p<0.01, difference is extremely remarkable.
brief summaryclinical test results shows, Chinese medicine composition of the present invention bestows in puerperal the incidence rate that calving milch cow effectively can prevent placenta retention in 2h, promotes that lochia drains, purification intrauterine environment in puerperal, and restoration of old ways uterus normal physiological function, improves the fertility performance of milch cow.
conclusionpreclinical safety evaluation and clinical pharrnacokinetics result of the test show, Chinese medicine composition of the present invention is one new product of Chinese medicine safely and effectively, effectively can prevent placenta retention, purification intrauterine environment in puerperal, restoration of old ways uterus normal physiological function, improves the fertility performance of milch cow.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. promote a Chinese medicine composition for involution of uterus of puerperal dairy cows, it is characterized in that: the weight proportion of described Chinese medicine composition Raw medicine is: Radix Angelicae Sinensis 20 – 50 parts, Rhizoma Chuanxiong 15 – 45 parts, Semen Persicae 15 – 40 parts, Rhizoma Zingiberis 10 – 35 parts, Herba Artemisiae Anomalae 18 – 45 parts, the Radix Paeoniae Alba 15 – 50 parts, Rhizoma Cyperi 15 – 45 parts, Fructus Crataegi 30 – 65 parts, Massa Medicata Fermentata 45 – 90 parts, Fructus Hordei Germinatus 25 – 65 parts.
2. according to a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows described in claim 1, it is characterized in that: the weight proportion of described Chinese medicine composition Raw medicine is: Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 25 parts, 25 parts, Semen Persicae, Rhizoma Zingiberis 15 parts, Herba Artemisiae Anomalae 30 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 50 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
3. a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows according to claim 1 or 2, is characterized in that: also comprise pharmaceutically acceptable adjuvant.
4. a kind of Chinese medicine composition promoting involution of uterus of puerperal dairy cows according to claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine composition is the molten Chinese medicine granules of alcohol.
5. a medicine, comprise crude drug and pharmaceutically acceptable adjuvant, it is characterized in that: the weight proportion of described crude drug is: Radix Angelicae Sinensis 20 – 50 parts, Rhizoma Chuanxiong 15 – 45 parts, Semen Persicae 15 – 40 parts, Rhizoma Zingiberis 10 – 35 parts, Herba Artemisiae Anomalae 18 – 45 parts, the Radix Paeoniae Alba 15 – 50 parts, Rhizoma Cyperi 15 – 45 parts, Fructus Crataegi 30 – 65 parts, Massa Medicata Fermentata 45 – 90 parts, Fructus Hordei Germinatus 25 – 65 parts.
6. according to the medicine described in claim 5, it is characterized in that: the weight proportion of described crude drug is: Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 25 parts, 25 parts, Semen Persicae, Rhizoma Zingiberis 15 parts, Herba Artemisiae Anomalae 30 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Cyperi 30 parts, Fructus Crataegi 50 parts, Massa Medicata Fermentata 60 parts and Fructus Hordei Germinatus 40 parts.
7. the preparation method of the arbitrary described Chinese medicine composition of claim 1-4, be the crude drug mixing of getting formula ratio, adding mass percent is 50% ethanol, carry out reflux, extract, heating decompression recycling ethanol, is concentrated into paste, add adjuvant, wet granulation after mix homogeneously, dry.
8. according to the preparation method described in claim 6, it is characterized in that: the addition of described ethanol is 5-10 times of crude drug weight.
9. according to the preparation method described in claim 6, it is characterized in that: described heating decompression recycling ethanol reclaims ethanol under the condition of 40-60 DEG C, 0.06-0.08MPa.
10. the arbitrary described Chinese medicine composition of claim 1-4 is at preparation prevention placenta retention, purification intrauterine environment in puerperal, and restoration of old ways uterus normal physiological function, improves the application in the medicine of the fertility performance of milch cow.
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| CN110882345B (en) * | 2019-12-30 | 2021-06-29 | 宁夏农林科学院动物科学研究所 | Traditional Chinese medicine composition for preventing and treating postpartum abdominal pain of dairy cows and preparation method thereof |
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