CN104587408A - New use of Qilin pills - Google Patents
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Abstract
The invention discloses a new use of Qilin pills, belonging to the field of traditional Chinese medicines. The Qilin pills are prepared from polygonum multiflorum preparata, herba ecliptae, herba epimedii, semen cuscutae, cynomorium songaricum, codonopsis pilosula, radix curcumae, fructus lycii, fructus rubi, rhizoma dioscoreae, radix salviae miltiorrhizae, radix astragali, radix paeoniae alba, green tangerine peel and mulberry. Apart from basic functions, the Qilin pills have the functions of promoting follicular development and ovulation, improving ovarian functions and the like, and have a perfect treatment effect on premature ovarian failure of parous or nonparous women. The invention is a discovery of a new use of Qilin pills.
Description
Technical field
The invention discloses a kind of novelty teabag of Chinese medicine kylin ball, belong to the field of Chinese medicines.
Background technology
Premature ovarian failure (POF) refers to that Menarcheal Age is normal, the normotrophic women of secondary sex characteristics, before 40 years old, occur secondary amenorrhea.Feature is that former or secondary amenorrhea raise with blood Gonadotropin Level and estrogen level reduction, and with a series of low estrogen symptoms in various degree as hectic fever hyperhidrosis, flush, hyposexuality etc.Make patient's geromorphism, if can not get adjusting timely and treating, the appearance of osteoporosis, cardiovascular and cerebrovascular disease chronic diseases can be caused, directly affect female life quality, have a strong impact on the normal work of women, bring considerable distress to its physical and mental health and love life simultaneously.Premature ovarian failure is a multi-pathogenesis disease, may due to congenital ovum negligible amounts, growing follicle latching process accelerates, or after birth, ovum is destroyed by different mechanisms and causes follicle to be exhausted too early, or promoting sexual gland hormone effect obstacle, although patient exists follicle, but follicle no longer shows periodically reaction to hormone in vivo, similarly be lose function, etc., these mechanism result in the generation of premature ovarian failure.
Clinical statistics finds, is not giving birth to and all existing in fertility crowd the patient of premature ovarian failure.After the crowd that do not give birth to is ill, infertile except causing, premature ovarian failure symptom is the earliest exactly the secretion minimizing of sexual life and the reduction of libido prestige, just slowly occurs amenorrhea, sexual anhedonia etc. afterwards.And to giving birth to crowd, the performance after premature ovarian failure is exactly the symptom of climacteric women, the namely sore waist and aching in the waist and the back etc. that causes of hectic fever, cardiopalmus, Spirit nerve symptoms of disease and osteoporosis.Spirit nerve symptoms of disease is irritable, insomnia, dreaminess, depression, emotional, easy anxiety, energy physically-draining, hypomnesis etc. mostly.Senilism patient geromorphism, all brings considerable distress to physical and mental health, figure appearance and love life.
But premature ovarian failure treatment is more difficult, and doctor trained in Western medicine adopts Hormone Replacement Therapy clinically, needs to use estrogen and progestogen under the guidance of doctor.Time research shows this estrogen and progestogen therapy, have certain effect, can symptom be improved, but unsatisfactory to the recovery of ovarian function, and after drug withdrawal simultaneously, symptom reappears, and makes ovary be in dependent status, has and causes the worse possibility of ovarian function.That is Hormone Replacement Therapy only serves the effect taken stopgap measures, and this method side effect is large, and life-time service exogenous hormones has the danger causing endometrium canceration, and increases the sickness rate of coronary heart disease and cholecystopathy.In recent years, along with Chinese medicine development, be more and more concerned with the chemotherapy that natural plant kind medicine substitutes in doctor trained in Western medicine.Chinese medicine has the integrally-regulated effect of multisystem too many levels, can improve ovarian function, improves ovarian reserve ability, and promote follicular development and ovulation, regulating menstruation and assisting pregnancy is antiabortive, is confirmed in long-term clinical practice.
In this context, kylin ball is used for the treatment of premature ovarian failure in clinical.Inventor finds kylin ball except having its basic effect in Long-term Clinical Observation, also has promotion follicular development and ovulation, improves the effects such as ovarian function, have good therapeutic effect to the premature ovarian failure of giving birth to or not giving birth to women.This is the discovery of a novelty teabag of kylin ball.
Kylin ball is made up of Radix Polygoni Multiflori Preparata, black Herba Ecliptae, Herba Epimedii, Semen Cuscutae, Herba Cynomorii, Radix Codonopsis, Radix Curcumae, Fructus Lycii, Fructus Rubi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, the Radix Astragali, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, Fructus Mori.The kylin ball that Guangdong Tai'antang Pharmaceutical Co., Ltd. produces, (authentication code: the accurate word Z10930034 of traditional Chinese medicines), its description shows that kylin ball has effect of kidney tonifying, essence replenishing, benefiting QI and nourishing blood.Be applicable to deficiency of kidney essence, vim and vigour are not enough, soreness of the waist and knees, fatigue and weakness, lustreless complexion, and man semen is rare clearly, impotence and premature ejaculation, woman's menoxenia; Or masculine sterility, female barrenness is shown in above-mentioned disease person.It has curative effect for female irregular menstruation, infertility, but does not then have applied research for the premature ovarian failure of married woman.
Effect (composition of this Chinese medicine is consistent with the kylin ball in the present invention) of a kind of Chinese medicine is described in number of patent application CN200910174452.0, this Chinese medicine has the effect for the treatment of sterility and infertility, tonification strengthening body and slow down aging, the infertility of this Chinese medicine to unmarried female has therapeutic effect, but does not then have applied research for the premature ovarian failure of married woman.Although it refer to the effect of slow down aging, the effect just in the resisting fatigue, raising anoxia endurance etc. of body, effect and the premature ovarian failure of the delaying human body caducity of this entirety then do not have dependency.
In this context, inventor proposes a kind of novelty teabag of kylin ball, i.e. the application of kylin ball in the premature ovarian failure for the treatment of women.
Summary of the invention
The object of the present invention is to provide a kind of novelty teabag of kylin ball, i.e. the application of kylin ball in the premature ovarian failure for the treatment of women.
Kylin ball can treat premature ovarian failure in clinical.Inventor finds kylin ball except having its basic effect in Long-term Clinical Observation, also has promotion follicular development and ovulation, improves the effects such as ovarian function, have good therapeutic effect to the premature ovarian failure of giving birth to or not giving birth to women.That is, kylin ball can treat the premature ovarian failure of having given birth to women, also can treat the premature ovarian failure of not giving birth to women.This is the discovery of a novelty teabag of kylin ball.
Kylin ball can treat the premature ovarian failure of not giving birth to women.Do not give birth to women ill after, topmost disease causes infertile, and the secretion minimizing of sexual life and the libido reduction of hoping besides, just slowly occurs amenorrhea, sexual anhedonia etc. afterwards.Kylin ball, by improving ovarian reserve ability, promotes follicular development and ovulation, the antiabortive symptom regulating premature ovarian failure of regulating menstruation and assisting pregnancy.
Kylin ball can treat the premature ovarian failure of having given birth to women.To giving birth to women, the performance after premature ovarian failure is exactly the symptom (i.e. climacteric syndrome) of climacteric women, namely the sore waist and aching in the waist and the back etc. that causes of hectic fever, cardiopalmus, Spirit nerve symptoms of disease and osteoporosis.Spirit nerve symptoms of disease is irritable, insomnia, dreaminess, depression, emotional, easy anxiety, energy physically-draining, hypomnesis etc. mostly.Senilism patient geromorphism, all brings considerable distress to physical and mental health, figure appearance and love life.Kylin ball by nourishing the liver and kidney, yin nourishing pathogenic fire reducing, improve the symptom that ovarian function regulates premature ovarian failure.
Kylin ball in the present invention is made up of Radix Polygoni Multiflori Preparata, black Herba Ecliptae, Herba Epimedii, Semen Cuscutae, Herba Cynomorii, Radix Codonopsis, Radix Curcumae, Fructus Lycii, Fructus Rubi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, the Radix Astragali, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, Fructus Mori.
Kylin ball in the present invention is by Radix Polygoni Multiflori 3%-15%, Herba Ecliptae 3%-10%, Herba Epimedii 3%-10%, Semen Cuscutae 3%-15%, Herba Cynomorii 3%-10%, Radix Codonopsis 3%-15%, Radix Curcumae 3%-10%, Fructus Lycii 3%-15%, Fructus Rubi 3%-15%, Rhizoma Dioscoreae 3%-10%, Radix Salviae Miltiorrhizae 3%-10%, Radix Astragali 3%-10%, Radix Paeoniae Alba 3%-10%, Pericarpium Citri Reticulatae Viride 1%-5%, Fructus Mori 5%-10% makes.
Wherein, above-mentioned Radix Polygoni Multiflori is Radix Polygoni Multiflori Preparata.
Kylin ball in the present invention can also be made up of following drug effective region:
Kylin ball volatile oil part 0.1 ~ 0.5 weight portion; Kylin ball water extraction position 15 ~ 25 weight portion; Radix Paeoniae Alba fine powder 4 ~ 8 weight portion
Wherein, acid 5 ~ 8% is put containing curcumenol 3 ~ 9%, d-limonen 12 ~ 20%, palm fibre in kylin ball volatile oil part.Kylin ball volatile oil part is prepared by the following method: get Pericarpium Citri Reticulatae Viride, Radix Curcumae, Herba Cynomorii, adds 10 times of water gagings, vapor distillation 5 hours, collects volatile oil (medicinal residues and water liquid for subsequent use), to obtain final product.
Containing icariin 0.2 ~ 0.4% in kylin ball water extraction position, stilbene glucoside (C
20h
22o
9) 0.5 ~ 1%, astragaloside 0.02 ~ 0.05%.Kylin ball water extraction position is prepared by the following method: get Radix Polygoni Multiflori Preparata, ink Herba Ecliptae, Herba Epimedii, Semen Cuscutae, Radix Codonopsis, Fructus Lycii, Fructus Rubi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Mori, and Pericarpium Citri Reticulatae Viride during extraction volatile oil, Radix Curcumae, the medicinal residues of Herba Cynomorii, add 10 times amount soak by water 2 times, each 2 hours, filter, merging filtrate, water liquid during united extraction volatile oil, be evaporated to relative density 1.10 ~ 1.15(60 DEG C), add ethanol and reach 60% ~ 80% to alcohol content, leave standstill, get supernatant, decompression recycling ethanol, continue to be evaporated to thick paste, drying under reduced pressure, pulverize, obtain.
Radix Paeoniae Alba fine powder is containing peoniflorin 1.2% ~ 2.5%.Radix Paeoniae Alba fine powder is prepared by the following method: get BAIYAO, is crushed to fine powder, sieves, and to obtain final product.
Each index components content described above all records according to Chinese Pharmacopoeia version in 2010 corresponding method of determination.Above-mentioned each medical material ingredient proportion is Radix Polygoni Multiflori 3%-15%, Herba Ecliptae 3%-10%, Herba Epimedii 3%-10%, Semen Cuscutae 3%-15%, Herba Cynomorii 3%-10%, Radix Codonopsis 3%-15%, Radix Curcumae 3%-10%, Fructus Lycii 3%-15%, Fructus Rubi 3%-15%, Rhizoma Dioscoreae 3%-10%, Radix Salviae Miltiorrhizae 3%-10%, Radix Astragali 3%-10%, Radix Paeoniae Alba 3%-10%, Pericarpium Citri Reticulatae Viride 1%-5%, Fructus Mori 5%-10%.
Kylin ball in the present invention can be that the Chinese patent medicine of regular pharmaceutical factory production is (as the kylin ball that Guangdong Tai'antang Pharmaceutical Co., Ltd. produces, authentication code: the accurate word Z10930034 of traditional Chinese medicines), also can be the decoction prepared by above-mentioned prescription flavour of a drug or other pharmaceutics acceptable preparations.That is, every medicine made according to above-mentioned medical material ratio, all within the scope of protection of the present invention.
beneficial effect
For verifying the novelty teabag of Chinese medicine of the present invention further, inventors performed animal pharmacodynamic experiment.
Test name: kylin ball is on the impact of premature ovarian failure sex hormone level in rats
1 material
Animal Wistar rat 40, male and female half and half, body weight 200 ± 20g.Purchased from Laboratory Animal Science portion of Traditional Chinese Medicine University Of Guangzhou.
Kylin ball: Guangdong Tai'antang Pharmaceutical Co., Ltd., lot number 20110805
Cyclophosphamide, Hengrui Medicine Co., Ltd., Jiangsu Prov..
Conjugated estrogen tablet: Wyeth pharmaceuticals produces.
Gonadal hormone is put and is exempted from detection kit (Sigma): purchased from Beijing Fu Rui bio-engineering corporation
2 methods and result
2.1 experimental technique
Female Wistar rats 40 is got in grouping, is divided at random: i.e. blank group (normal group), model group, kylin ball group, positive drug group (conjugated estrogen tablet group), often organizes 10.
Modeling is except blank group, and all the other are group employing birth the 9th age in days female rats children Mus respectively, cyclophosphamide 8mg/ (kgd) modeling in 14 days of continuous lumbar injection.
Testing program 1) kylin ball group: modeling terminates latter 24 hours by kylin ball 35g/kg gavage, every day 1 time.2) Western medicine group: modeling terminates latter 24 hours, by conjugated estrogen tablet 0.075mg/kg gavage, every day 1 time.3) model group: modeling terminates latter 24 hours by normal saline 2mL/kg gavage, every day 1 time.4) blank group (blank group): freely drink water.Sampling originally, is treated 35 days continuously.At last therapeutic after 24 hours, femoral artery is got blood and is surveyed serum sex hormone level.Disconnected neck puts to death rat, cuts open the belly and gets ovary, retains specimen and censorship by the regulation of corresponding Testing index.
Observation index 1) rat blood serum FSH, E2 horizontal detection; 2) rat ovary Histomorphological; 3) mature follicle quantity and corpus luteum inspection: take out ovary by each group and make tissue slice, HE dyes, at light Microscopic observation.And count mature follicle sum and corpus luteum number.
Statistical procedures test data adopts the analysis of SPSS12. 0 statistical software, and data represent with (mean ± standard deviation).
2.2 result
2.2.1 serum sex hormone level testing result, in table 1.
Table 1 serum sex hormone level testing result (X ± S)
| Group | Number of animals (only) | E2(pg/ml) | FSH(mIU/ml) |
| Blank group | 10 | 8.42±0.55 | 0.72±0.30 |
| Model group | 10 | 3.25±0.51 | 1.36±0.56 |
| Positive drug group | 10 | 7.34±1.21 * | 0.92±0.32 * |
| Kylin ball group | 10 | 6.73±1.05 * | 0.85±0.27 * |
Compare with model group, * P<0.05, * * P<0.01
Analyze from table 1, model group E2 level reduces, and compares, have significant difference with blank group; After treatment, E2 level can raise, and its curative effect is best (P<0.05) with positive drug group and kylin ball group successively.FSH level, positive drug group and kylin ball group compare with model group, and difference all has significance, P<0.05.Visible, the kylin ball in the present invention has good effect to the serum sex hormone level recovering rat, thus improves estrogen level, promotes follicular development, plays therapeutical effect to premature ovarian failure.
2.2.2 respectively group rat mature follicle number and corpus luteum number compare, and the results are shown in Table 2.
Table 2 respectively group rat mature follicle number and corpus luteum number compares (X ± S, individual)
| Group | Number of animals (only) | Mature follicle number | Corpus luteum number |
| Blank group | 10 | 8.5±1.6 | 7.2±0.8 |
| Model group | 10 | 0.7±0.2 | 1.3±0.4 |
| Positive drug group | 10 | 7.6±0.6 * | 6.1±0.9 * |
| Kylin ball group | 10 | 7.2±1.2 * | 6.4±0.6 * |
Compare with model group, * P<0.05, * * P<0.01
2.2.3 ovary tissue morphological examination
Om observation rat ovary tectology, result is as follows: 1) blank group: Ovarian Volume is large, and ovarian follicular growth enlivens, visible Follicles, and granular cell level is many, and follicular fluid content is many; Corpus luteum development is good, and volume is large, and corpus luteum cell space enriches.2) model group: ovary body atrophy, ovarian follicular growth is few, part replace by fibrous tissue; Corpus luteum quantity is few, and atretic follicle is many.3) kylin ball group: ovarian follicular growth is more, granular cell level is more, and corpus luteum is many, and lutein cell is abundanter, close to normal group.4) positive drug group: Follicles growing state is good, corpus luteum growth is good, close to normal group.
Visible, the kylin ball in the present invention is better to the recovery effects of ovary tissue, after taking and normal group form close.Obviously can promote mature egg cell and the corpus luteum number of rat, kylin ball has estrogen-like effects, but not simple estrogen substituted role, but by the function point analysis to neuro-endocrine system, promote the recovery of hypothalamic-pituitary-ovarian function, to immunity POF, there is preventive and therapeutic effect.Its effect is not single, independently, but many-sided, comprehensive, the advantage place of this medicine of the present invention just.
Detailed description of the invention
Enumerate embodiment below, further illustrate the present invention, each embodiment, only for illustration of the present invention, does not limit the present invention:
Embodiment 1
Certain female, 28 years old, menoxenia, through measuring rareness, 3 years after marriage unpregnancies.Clinical diagnosis is premature ovarian failure.After taking kylin ball (Guangdong Tai'antang Pharmaceutical Co., Ltd.'s production), every day twice, each 6g; After first 3 months courses for the treatment of, menstrual onset strengthens through amount, and menstrual phase 4 days, takes 2 courses for the treatment of continuously, monthly about 4-6 days menstrual onset time phase difference time; After taking three 9 months courses for the treatment of, menstrual blood volume and time all basic laws, sexual life is normal, and menstrual cycle basic law, is ovulatory menstruation.Take medicine to 11st month, the pregnant inspection of hospital, confirm conceived.
Embodiment 2
Certain female, 35 years old, company middle level leader, give birth to latter 2 years, menstruation comes once about half a year, through measuring rareness, hyposexuality, hectic fever hyperhidrosis, with insomnia and dreamful sleep, tired, irritated, nervous (clinical diagnosis is premature ovarian failure).Start to take kylin ball (Guangdong Tai'antang Pharmaceutical Co., Ltd.'s production), each serving with 6g, every day 2 times, after first 3 months course for the treatment of, menstruation is monthly risen, through measuring rareness, and menstrual phase 2 days, after taking 26 months courses for the treatment of continuously, endocrine recovers normal, and menstruation recovery is normal, sleep improvement, the colour of skin becomes clear, energetic.
Embodiment 3
Year February in June, 2011 to 2013 carries out the observation of curative effect of kylin pill for curing premature ovarian failure of women in the institute of traditional Chinese medicine of Guangdong.
1. choose qualified case to include in.Inclusive criteria: 1. the age is between 25 ~ 45 years old, gives birth to; 2. Western medicine diagnose standard and traditional Chinese medical science Western medicine diagnose standard person is met; 3. do not merge and use other drug therapist; 4. patient willingness participates in this research and completes clinical observers.Exclusion standard: 1. age < 25 one full year of life or > 45 years old person or nullipara; 2. to medicine allergy sufferers; 3. severe primary disease and the psychotics such as cardiovascular, lung, liver, kidney and hemopoietic system is associated with; 4. allly inclusive criteria is not met, not by regulation medication person; 5. cannot judge that curative effect or data are not congruent to affect the treatment and safety judgement person.Totally 48 examples, 25 ~ 45 years old age, average (34.2 ± 4.5) year, the course of disease is the shortest 6 months, the longest 5 years, average (2.6 ± 0.8) year.
2. therapeutic scheme.Take kylin ball (Guangdong Tai'antang Pharmaceutical Co., Ltd.'s production), a 6g, twice on the one.Within 3 months, be 1 course for the treatment of to treat, totally 3 courses for the treatment of.
3. observation index.1. clinical efficacy (clinical symptoms improvement situation); 2. sex hormone level detects: respectively at the forward and backward detection for the treatment of two groups of patients serum's estrogen (E2), FSH (FSH), interstitialcellstimulating hormone (ICSH) (LH), progesterone (P), prolactin antagonist (PRL) level; 3. peripheral T lymphocyte subsets counts: respectively at the forward and backward detection for the treatment of two groups of T Lymphocyte Subsets of Peripheral Blood CD3+, CD4+, CD8+, CD4+/CD8+ situations of change.
4. efficacy assessment standard.Formulate with reference to " new Chinese medicine guideline of clinical investigations " related standards.1. clinical cure: menstruation recovery normal cycle, low estrogen syndrome group disappears substantially, maintains more than 3 menstrual cycle after drug withdrawal, and blood serum E2, LH, FSH are normal; 2. effective: menstruation is close to normal cycle, and automatically rise in 3 months 1 time after drug withdrawal, low estrogen syndrome group alleviates, blood serum E2, FSH, LH are close to normal; 3. effective: through treating 3 months, menstrual onset more than 1 time, low estrogen syndrome group alleviates, and blood serum E2, FSH, LH have fluctuation; 4. invalid: through treating 3 months, menstruation is not risen, group is without improvement for low estrogen syndrome, and blood serum E2, FSH, LH are unchanged.
5. statistical method.SPSS12.0 software is adopted to process.Enumeration data compares employing chi-square criterion, and measurement data adopts t inspection.
6. result.Clinical cure 22 example, effective 17 examples, effective 4 examples, invalid 5 examples, total effective rate 89.6%.
Above-described embodiment shows, kylin ball has been given birth in premature ovarian failure of women in treatment and had definite curative effect.This is its new discovery on original function cures mainly, and the invention of this novelty teabag is that clinical chain reaction in patients with premature ovarian provides new, effective medication and selects, and will benefit extensive patients.
Embodiment 4
Prepared by kylin pill thing:
Get kylin ball volatile oil part 3g(and put acid 7.2% containing curcumenol 5.3%, d-limonen 18.3%, palm fibre), kylin ball water extraction position 200g(icariin 0.32%, stilbene glucoside (C
20h
22o
9) 0.76%, astragaloside 0.038%), Radix Paeoniae Alba fine powder 60g(is containing peoniflorin 2.1%), by kylin ball water extraction position and Radix Paeoniae Alba fine powder mix homogeneously, spray into kylin ball volatile oil part, evenly, rub ball bar with the hands, pill grain, to obtain final product.
[wherein, kylin ball volatile oil part is prepared by the following method: get Pericarpium Citri Reticulatae Viride, Radix Curcumae, Herba Cynomorii, adds 10 times of water gagings, vapor distillation 5 hours, collects volatile oil (medicinal residues and water liquid for subsequent use), to obtain final product.
Kylin ball water extraction position is prepared by the following method: get Radix Polygoni Multiflori Preparata, ink Herba Ecliptae, Herba Epimedii, Semen Cuscutae, Radix Codonopsis, Fructus Lycii, Fructus Rubi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Mori, and Pericarpium Citri Reticulatae Viride during extraction volatile oil, Radix Curcumae, the medicinal residues of Herba Cynomorii, add 10 times amount soak by water 2 times, each 2 hours, filter, merging filtrate, water liquid during united extraction volatile oil, be evaporated to relative density 1.10 ~ 1.15(60 DEG C), add ethanol and reach 80% to alcohol content, leave standstill, get supernatant, decompression recycling ethanol, continue to be evaporated to thick paste, drying under reduced pressure, pulverize, obtain.
Radix Paeoniae Alba fine powder is prepared by the following method: get BAIYAO, is crushed to fine powder, sieves, and to obtain final product.】
Certain female, 42 years old, full-time housewife, give birth to latter 10 years, menstruation comes once about half a year, through measuring rareness, hyposexuality, hectic fever hyperhidrosis, with insomnia and dreamful sleep, tired, irritated, nervous (clinical diagnosis is premature ovarian failure and climacteric syndrome).Start to take above-mentioned kylin ball, each serving with 6g, every day 2 times, after first 3 months course for the treatment of, menstruation is monthly risen, through measuring rareness, menstrual phase 3 days, after taking 26 months courses for the treatment of continuously, endocrine recovers normal, and menstruation recovery is normal, sexual life is harmonious, sleep improvement, mood relaxes, and memory recovers good.
Claims (3)
1. the novelty teabag of kylin ball, is characterized in that kylin ball is used for the treatment of the premature ovarian failure of women.
2. the novelty teabag of kylin ball according to claim 1, is characterized in that kylin ball is made up of Radix Polygoni Multiflori Preparata, black Herba Ecliptae, Herba Epimedii, Semen Cuscutae, Herba Cynomorii, Radix Codonopsis, Radix Curcumae, Fructus Lycii, Fructus Rubi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, the Radix Astragali, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, Fructus Mori.
3. the novelty teabag of kylin ball according to claim 1 and 2, is characterized in that kylin ball is by Radix Polygoni Multiflori 3%-15%, Herba Ecliptae 3%-10%, Herba Epimedii 3%-10%, Semen Cuscutae 3%-15%, Herba Cynomorii 3%-10%, Radix Codonopsis 3%-15%, Radix Curcumae 3%-10%, Fructus Lycii 3%-15%, Fructus Rubi 3%-15%, Rhizoma Dioscoreae 3%-10%, Radix Salviae Miltiorrhizae 3%-10%, Radix Astragali 3%-10%, Radix Paeoniae Alba 3%-10%, Pericarpium Citri Reticulatae Viride 1%-5%, Fructus Mori 5%-10% makes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113855715A (en) * | 2021-10-30 | 2021-12-31 | 佛山市欣康迈科技有限公司 | Application of cynomorium songaricum extract in preparation of ovarian maintenance traditional Chinese medicine product |
| CN116603030A (en) * | 2023-05-27 | 2023-08-18 | 陕西年青保制药有限公司 | Traditional Chinese medicine composition and preparation for premature ovarian failure and preparation process thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855715A (en) * | 2021-10-30 | 2021-12-31 | 佛山市欣康迈科技有限公司 | Application of cynomorium songaricum extract in preparation of ovarian maintenance traditional Chinese medicine product |
| CN116603030A (en) * | 2023-05-27 | 2023-08-18 | 陕西年青保制药有限公司 | Traditional Chinese medicine composition and preparation for premature ovarian failure and preparation process thereof |
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