CN100352472C - Kidney-replenishing yang-invigorating medicine and its preparing method - Google Patents
Kidney-replenishing yang-invigorating medicine and its preparing method Download PDFInfo
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Abstract
The present invention discloses a kidney tonifying and yang strengthening medicine prepared from ginseng, desertliving cistanche, antlers, asiatic cornelian cherry fruit, eucommia bark, songaria cynomorium herbs, epimedium herbs, mornda root, barbary wolfberry fruit, fleeceflower root, indian bread and radix glycyrrhiza in terms of certain weight proportion. The medicine can be made into any common oral preparation. The medicine has the functions of kidney tonification, yang strengthening, essence filling and marrow benefiting, and can be effectively used for treating diseases, such as waist and knee soreness and softness, impotence, premature ejaculation, etc. in clinical treatment.
Description
Technical field
The present invention relates to medicine of a kind of kidney invigorating and YANG supporting and preparation method thereof, belong to tcm field.
Background technology
Along with rapid development of social economy, the productivity's raising greatly, people's the material and the level of cultural life improve constantly, and average life obviously prolongs, and aged ratio increases gradually in the population, and the old man requires to improve the quality of living and have good health and a long life; Simultaneously between twenty and fifty crowd, because the high competition and the bad habit of social work and life, the ratio of suffering from sexual impotence and seminal emission patient in the society increases, people require to give health care and treatment, and hoping has the effective Chinese medicine health care product of a kind of safety non-toxic, both can health body-building, strong body lengthens one's life, have the effect of treatment yang deficiency again, anti-ageing health care, health are lengthened the life, body-building and tonifying yang has definite effect.Traditional single the kidney invigorating of some temperature compensation medicines will be suffered from a deficiency of the kidney and four deficiency of five ZANG-organs decrease treatment and disconnect, and causing the kidney invigorating is not have effect, be exactly after the drug withdrawal the various symptoms of suffering from a deficiency of the kidney stage a comeback again.Suoyang gujing pills, Yang-tonifying kidney-protecting pill, incomparable Rhizoma Dioscoreae ball, YISHENLING granule, WUZIYANZONG WAN, powerful army's ball, NANBAO JIAONANG, three-animal penes shake male ball, LONGFENGBAO JIAONANG and Yougui Wan, the kidney-Yang-Reinforcing Bolus are arranged on the existing domestic market, more than these the kidney invigorating patent medicine, some is sold for a long time on market, certain guarantor's kidney and enhancing body effect is arranged, but its curative effect or less, or effect is slow, or relatively poor to whole tonification effect, is not patient's favor.In addition, the invention of the quick erection function medicine of Western medicine male is come out, it is the invention greatly of nineteen nineties, as viagra (sldenafil), gift comes the up-to-date release tadalafil of company etc., can treat erection disturbance, quick-acting is its advantages, but headache, flushing, vision changes and the cardiac accident incident is its apparent side effect.Particularly it consumes human body energy, loses with causing for a long time, and health is caused the smart consumption of suffering from a deficiency of the kidney, and positive QI-insufficiency is its weak point.
Summary of the invention
Therefore, people wish to find the medicine of the little kidney invigorating and YANG supporting of a kind of better efficacy, side effect.Up to now, also do not find the report of any relevant medicine of the present invention.The inventor, in conjunction with the experience handed down from one's ancestors of long-term clinical application and through modern science processing development, has obtained the oral medicinal herb medicine that is used for kidney invigorating and YANG supporting of a kind of safety, produce effects finally, thereby has finished the present invention according to the Chinese traditional treatment theory of suffering from a deficiency of the kidney.
Purpose of the present invention is exactly that a kind of better efficacy, the little kidney invigorating and YANG supporting medicine of side effect will be provided.
Another object of the present invention provides the preparation method of this medicine.
Medicine of the present invention is prepared from by 12 flavor crude drug such as Radix Ginseng, Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae (saline stir-fry), Herba Cynomorii, Herba Epimedii, Radix Morindae Officinalis, Fructus Lycii, Radix Polygoni Multiflori Preparata, Poria, Radix Glycyrrhizae (processed with honey), has the strong waist of kidney invigorating and YANG supporting, the QI invigorating spermatogenesis is mended the effect of marrow, can be used for treating diseases such as soreness of the waist and knees, sexual impotence, premature ejaculation.The first-selected Radix Ginseng of medicament composing prescription of the present invention, Cornu Cervi Pantotrichum, Radix Ginseng is sweet, and is flat, returns spleen, lung, heart channel, strongly invigorating primordial QI, invigorating the spleen to benefit the lung promotes the production of body fluid, and tonifying five ZANG-organs is arranged, and peace spirit is decided soul, and the physical strength reinforcing effect is arranged; Cornu Cervi Pantotrichum is the beast of pure sun, and the top, mountain peak is given birth at the angle, the product that flesh and blood is in love, and nature and flavor are sweet, and are salty, and temperature is returned kidney, Liver Channel.Kidney-replenishing is arranged, warm kidney and replenishing marrow, spermatogenesis benefit blood function cures mainly first YANG deficiency, kidney yang deficiency, bone strengthening plays flaccidity, and Radix Ginseng, Cornu Cervi Pantotrichum have kidney invigorating and YANG supporting, and the QI invigorating Spermatogenic action is a monarch drug.The Fang Zhongyong Herba Cistanches, sweet, salty, temperature is gone into kidney, large intestine channel, and kidney invigorating and YANG supporting is warm and soft and moist; Herba Cynomorii, Gan Wen goes into liver, kidney channel, kidney invigorating and YANG supporting, benefit is smart supporing yang, and the nourishing muscle and tendon Conclusion Decreasing has good effectiveness to impotence due to deficiency of the kidney, weakness of the waist and knees etc.; Herba Epimedii, i.e. Herba Epimedii, suffering, temperature is gone into liver, kidney channel, warming the kidney to activate YANG is used for the sexual impotence spermatorrhea, the disease of insufficiency of kidney-YANG; Radix Morindae Officinalis, suffering, sweet, tepor is gone into kidney channel, and temperature is not and dry, and tonify without causing stagnation helps kidney yang, and bone and muscle strengthening is used for impotence and seminal emission; The Cortex Eucommiae, sweet, temperature is gone into liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening is used for deficiency of the liver and kindey, and soreness of waist and knee joint is weak, sexual impotence.Above-mentioned Herba Cistanches, Herba Cynomorii, Herba Epimedii, Radix Morindae Officinalis and the Cortex Eucommiae five tastes help kidney yang principal drug assistance altogether, and to strengthen the kidney invigorating and YANG supporting of full side, the strong waist effect of spermatogenesis is a ministerial drug.Zhao Xianke once had " fire like water is main, water is former with fire.So the cloudy person who gets asks water in the fire, its essence is inexhaustible; The positive person who gets seeks fire in the water, it is bright not to put out " to discuss, so " kind YANG invigorating person must be in treating YANG within YIN, then positive cloudy helping and biochemical infinite ".For this reason, reuse Fructus Lycii in this, nature and flavor are sweet, and are flat, return kidney, Liver Channel.The tool YIN nourishing and the production of body fluid promoting, enriching blood and replenishing vital essence, nourishing the liver and kidney, soft and moist many liquid, Yin-nourishing and Yang-supporting can be used for deficiency of the liver and kindey, seminal emission, soreness of waist and knee joint and making eye bright; Fructus Corni, acid, puckery, tepor is gone into liver, kidney channel.Liver and kidney tonifying, arresting seminal emission is controlled the soreness of waist; Radix Polygoni Multiflori Preparata, nature and flavor are sweet, and hardship is puckery, and tepor is returned liver, the heart, kidney channel.Invigorating the liver and kidney is arranged, support the essence and blood effect; Poria, sweet, flat, property mitigation, function heart-spleen boosting, diuretic is wet, spleen invigorating and in, mend and produce highly, sharp and not violent, can set upright, again can be eliminating evil, can assist all medicines to strengthen effect, above-mentioned Fructus Lycii, Fructus Corni, Radix Polygoni Multiflori and Poria help monarch-minister drug altogether, are adjuvant drug to strengthen its kidney invigorating and YANG supporting.Radix Glycyrrhizae is in order to relaxing the property of all medicines in the side, and can the tonifying the spleen and stomach deficiency and gas in the benefit, and coordinating the actions of various ingredients in a prescription is a messenger drug.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each crude drug consumption proportion of preparation medicine of the present invention all has better curative effect in following ranges:
10～20 parts of 25～35 parts of Radix Ginsengs, 25～35 parts of Herba Cistanches, 35～45 parts in Cornu Cervi Pantotrichum, 25～35 parts of Fructus Corni, 25～35 parts of saline Cortex Eucommiae (parched), 25～35 parts of Herba Cynomoriis, 25～35 parts of Herba Epimedii, 25～35 parts of Radix Morindae Officinaliss, 35～45 parts of Fructus Lycii, 35～45 parts of Radix Polygoni Multiflori Preparatas, 25～35 parts in Poria and Radix Glycyrrhizae (processed with honey).
Be preferably: 15 parts of 30 parts of Radix Ginsengs, 30 parts of Herba Cistanches, 40 parts in Cornu Cervi Pantotrichum, 30 parts of Fructus Corni, 30 parts of saline Cortex Eucommiae (parched), 30 parts of Herba Cynomoriis, 30 parts of Herba Epimedii, 30 parts of Radix Morindae Officinaliss, 40 parts of Fructus Lycii, 40 parts of Radix Polygoni Multiflori Preparatas, 30 parts in Poria and Radix Glycyrrhizae (processed with honey).
The active component of medicine of the present invention can prepare in order to the below method;
A) take by weighing each crude drug of described weight proportion, wherein Poria was divided into two parts pulverize separately by about 2: 1 and becomes coarse powder and fine powder, and is standby;
B) get Radix Ginseng, Fructus Lycii, Herba Cynomorii, Poria and Radix Glycyrrhizae coarse powder, add 5-10 times of water gaging and decoct 2-3 time, each 1--2 hour, filter, merging filtrate and concentrated concentrated solution 1, standby;
C) get Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae, Herba Epimedii, Radix Morindae Officinalis and Radix Polygoni Multiflori coarse powder, add 5--10 and doubly measure the 30-70% alcohol heating reflux 2-3 time, each 1-2 hour, filter, merging filtrate, recovery ethanol is not to there being the alcohol flavor, and it is 1.30～1.35 that remaining aqueous solution is concentrated into relative density, gets concentrated solution 2;
D) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder adds the Poria fine powder, and mix homogeneously just has been prepared into the active component of medicine of the present invention.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as drug excipients such as disintegrating agent, lubricant, binding agents, be prepared into any peroral dosage form commonly used with conventional method of Chinese medicinal, as capsule, soft capsule, drop pill, granule, tablet or oral liquid etc.
Deficiency of the kidney is accumulation damage year in year out, can not become strong within several days even several hrs, and helping property of kidney tonifying must be incremental, and the kidney invigorating must be put safety in the first place.Therefore, science, safe the kidney invigorating at first maintenance are in harmonious proportion the five internal organs, eliminate the five big factors of being impairment of the kidney comprehensively, promptly weak, the deficiency of the lung of heart failure, spleen, liver become silted up, deficiency of the kidney, by heart tonifying, foster lung, spleen invigorating, liver nourishing, the kidney invigorating, reach the five internal organs harmony; Two, two-ways regulation, reach negative and positive by tonifying both YIN and YANG and coordinate; Three, rebuild " kidney balance ", coordinate, reach the balance of new essence, gas, blood by the five internal organs regulating YIN and YANG, finally reach safe, quick, persistent the kidney invigorating effect, a kidney five is controlled, and breaks through traditional the kidney invigorating method slow limitation that takes effect simultaneously, more effective than temperature compensation, more safer than quick-acting.Medicine of the present invention bases oneself upon this aim just, and the classical prescription and the proved recipe exploitation of excavating the Chinese medicine treasure-house form.Confirm that through Preliminary Clinical Observation this medicine is used for diseases such as soreness of the waist and knees, sexual impotence, premature ejaculation, and is evident in efficacy.Its existing effect of YANG invigorating faster, kidney invigorating and YANG supporting fundamentally again, beneficial marrow and benefitting semen, enrich and benefit essence and blood is kept fit brain-strengthening, reaches strong physique effect, makes every effort to promote Cause ﹠ Symptom Solution, is the new Chinese medicine preparation of an ideal safe produce effects.This product is made dosage forms such as hard capsule, can cover the medicine foreign odor, can play simultaneously the effect of protection against the tide, anti-oxidation, lucifuge, improves stability of drug; And supplementary product consumption is few, and is fast in the gastrointestinal tract disintegration rate.This product is the medicine that is used for the treatment of diseases such as sexual impotence, premature ejaculation, and medicining cycle is long, makes patent medicine, help the patient to take for a long time, and carry, convenient transportation.
The specific embodiment
Below by test the example further set forth medicine of the present invention (to call capsule for nourishing kidney and strengthening Yang in the following text) beneficial effect.
The pharmacodynamic study of [test example 1] capsule for nourishing kidney and strengthening Yang
One, test objective:
Capsule for nourishing kidney and strengthening Yang has kidney invigorating and YANG supporting, the merit of life essence-filling, marrow-benefitting, and the clinical soreness of the waist and knees that is used for, the impotence and premature ejaculation curative effect is better, for verifying its effect and inquiring into its effect characteristics, has observed the influence of this capsule to diversity dysfunction animal model.
Two, test material:
1, capsule for nourishing kidney and strengthening Yang: mainly form by medicines such as Radix Ginseng, Herba Cistanches, by Fructus Citri tangerinae core hall pharmacy (Macao) company limited, Yi Kang institute of materia medica, high and new technology industrial development zone, Zhengzhou provides, lot number 041122, every gram capsule 's content is equivalent to the 3.75g raw medicinal herbs, the heavy 0.5g of every capsules, every day 3 times, each 2 (are equivalent to 0.05g patent medicine/kg).
2, NANBAO JIAONANG: Tianjin man of great strength Pharmacy stock Co., Ltd produces, lot number 020427, every 0.3g, 2～3 of every days; Every day 2 times;
3, hydrocortisone, modern Kazakhstan, Shanghai gloomy Shangqiu pharmaceutcal corporation, Ltd produces lot number 041203;
4, estradiol benzoate, Shanghai General Pharmaceutical Co., ltd. produces, lot number 030702;
5, Progesterone, Shanghai General Pharmaceutical Co., ltd. produces, lot number 030704;
6, formaldehyde, Chinese Laiyang City chemical industry company limited are in pairs produced lot number 040801;
7, iodine [
125I]-hydrocortisone radioimmunoassay, RIA medicine box, Ke Meiya Bioisystech Co., Ltd in Beijing produces, lot number 050425; Iodine [
125I]-serum testosterone radioimmunoassay, RIA medicine box, Ke Meiya Bioisystech Co., Ltd in Beijing produces, lot number 050425.
Three, experiment and medication:
1, observation causes the influence of mice insufficiency of kidney-YANG model to hydrocortisone
Get 60 of body weight 18～21g male mices, be divided into 6 groups at random, wherein make hydrocortisone insufficiency of kidney-YANG model for 5 groups.Modeling method be every Mus intramuscular injection hydrocortisone 30mg/kg (3mg/ml, 0.1ml/10g), every day 1 time, continuous 7 times, in modeling perfusion simultaneously.Modeling gavages big respectively for 5 groups, in, low dose of capsule for nourishing kidney and strengthening Yang suspension (is made into 0.075g/ml with 0.2%CMC, 0.05g/ml, 0.025g/ml, 0.2ml/10g, 1.5g/kg, 1.0g/kg, 0.5g/kg, be equivalent to 30 times of the clinical consumption of people, 20 times, 10 times), the NANBAO JIAONANG suspension (is made into 0.03g/ml with 0.2%CMC, 0.2ml/10g, 0.6g/kg, be equivalent to 20 times of clinical consumption), with 0.2%CMC physiological salt liquid (0.2ml/10g) with volume, other has 1 group to be the blank group, and not modeling is only given with volume 0.2%CMC normal saline.Administration every day 1 time, successive administration 7 days.1h after last 1 administration puts into mice autonomic activities instrument with mice, observes autonomic activities situation in the mice 10 minutes.Then mice is put into little wire mesh cage, 5 in every cage is put into-20 ℃ of ice pivots with little mouse cage, observes the mice time-to-live.
2, carried out in addition to repeat to suspend in midair influence experiment that the stress stimulation mice makes it the damaged model mice of sexual behaviour, to the experiment of rat mating ability influence, to the experiment of the main gonad organ weight influence of rat with to the experiment of castrated rats influence.Dosage is in the experiment:
NANBAO JIAONANG (positive control drug): mice consumption 0.6g/kg, rat consumption 0.3g/kg;
Capsule for nourishing kidney and strengthening Yang: the mice consumption is respectively 0.5,1.0 and 1.5g patent medicine/kg (be equivalent to respectively clinical plan consumption 10,20,30 times); The rat consumption is respectively 0.25,0.5 and 0.75g one-tenth/kg (be equivalent to respectively clinical plan consumption 5,10,15 times).
Four, experimental result:
Capsule for nourishing kidney and strengthening Yang gavaged for mice in continuous 7 days with the dosage of 1.5g/kg, 1.0g/kg, 0.5g/kg, can significantly increase autonomic activities number of times in the insufficiency of kidney-YANG mice 10min, significantly increase the mice number of times of standing, the time that the significant prolongation mice survives in-20 ℃ of environment.Capsule for nourishing kidney and strengthening Yang gavaged for mice in continuous 10 days with the dosage of 1.5g/kg, 1.0g/kg, 0.5g/kg, can significantly reduce to repeat to suspend in midair to cause the male Mus of the damaged model of mice sexual behaviour female Mus is pounced on the incubation period of catching, and significantly increased to pounce on and caught number of times.Capsule for nourishing kidney and strengthening Yang gavaged for rat in continuous 15 days with the dosage of 0.75g/kg, 0.5g/kg, 0.25g/kg, can significantly shorten male rat catches incubation period pouncing on of female rats, obviously shorten ejaculation latency, can significantly increase to pounce on and catch number of times and obviously increase ejaculation frequency; Can obviously increase the weight of epididymis, seminal vesicle; Adrenal gland's glomerular zone, zona fasciculata and reticular zone cell there is obvious increase effect, can promote the secretion of prostate body of gland, make spermatogonium chromosome basophilia intensification in the convoluted tubule of testis, testicular spermatogenic there is facilitation, make the expansion of epididymis tube chamber, sperm increases, and makes penis spongy body increase on every side.Capsule for nourishing kidney and strengthening Yang gavaged for castrated rats in continuous 14 days with the dosage of 1.5g/kg, 1.0g/kg, 0.5g/kg, can significantly shorten erection incubation period; Can significantly shorten male Mus pouncing on of female Mus caught incubation period, obviously increase to pounce on and catch number of times; Obviously increase levator ani weight, significantly improve the serum cortisol level; The prostate of promotion and seminal vesicle secretory action are arranged, the effect of the cavernous body of penis of increase is arranged, the levator ani of promotion growth effect is arranged.
Five, conclusion:
Capsule for nourishing kidney and strengthening Yang toxicologic study result shows that this poison of drug is lower.Pharmacodynamic study is the result show, this medicine can significantly improve the insufficiency of kidney-YANG state of mice; Can obviously shorten pouncing on of rat and catch incubation period, increase to pounce on and catch number of times, and can shorten ejaculation latency increase ejaculation frequency; The promotion glucocorticoid is arranged, and androgenic effect, the Spermatogenic action that increases prostate secretion and short testis is arranged, and cavernous body of penis is increased.And the erection incubation period of energy significant prolongation animal, shorten to pounce on and catch incubation period, increase and catch number of times.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
The capsule preparation of [embodiment 1] medicine of the present invention
A) take by weighing Radix Ginseng 30 grams, Herba Cistanches 30 grams, Cornu Cervi Pantotrichum 40 grams, Fructus Corni 30 grams, the Cortex Eucommiae (saline stir-fry) 30 grams, Herba Cynomorii 30 grams, Herba Epimedii 30 grams, Radix Morindae Officinalis 30 grams, Fructus Lycii 40 grams, Radix Polygoni Multiflori Preparata 40 grams, Poria 30 grams and Radix Glycyrrhizae (processed with honey) 15 grams, standby;
B) get Radix Ginseng, Fructus Lycii, Herba Cynomorii, 20 gram Poria and Radix Glycyrrhizae coarse powder, add 7 times of water gagings and decoct 3 times, each 2 hours, filter, merging filtrate and concentrate concentrated solution 1, standby;
C) get Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae, Herba Epimedii, Radix Morindae Officinalis and Radix Polygoni Multiflori coarse powder, add 7 times of amount 50% alcohol heating reflux 3 times, each 2 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, and it is 1.30～1.35 concentrated solution 2 that remaining aqueous solution is concentrated into relative density;
D) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, add 10 gram Poria fine powders, the snap fit capsule of packing into behind the mix homogeneously.
The preparation tablets of [embodiment 2] medicine of the present invention
A) take by weighing each crude drug by following weight proportion:
Radix Ginseng 35 grams, Herba Cistanches 35 grams, Cornu Cervi Pantotrichum 45 grams, Fructus Corni 35 grams, the Cortex Eucommiae (saline stir-fry) 35 grams, Herba Cynomorii 35 grams, Herba Epimedii 35 grams, Radix Morindae Officinalis 35 grams, Fructus Lycii 45 grams, Radix Polygoni Multiflori Preparata 45 grams, Poria 35 grams and Radix Glycyrrhizae (processed with honey) 20 grams, standby;
B) get Radix Ginseng, Fructus Lycii, Herba Cynomorii, 24 gram Poria and Radix Glycyrrhizae coarse powder, add 10 times of water gagings and decoct 3 times, each 2 hours, filter, merging filtrate and concentrate concentrated solution 1, standby;
C) get Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae, Herba Epimedii, Radix Morindae Officinalis and Radix Polygoni Multiflori coarse powder, add 10 times of amount 70% alcohol heating reflux 3 times, each 2 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, and it is 1.30～1.35 concentrated solution 2 that remaining aqueous solution is concentrated into relative density;
D) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, add 11 gram Poria fine powders and adjuvant and make granule, and compacting is in flakes.
The preparation of [embodiment 3] granule of the present invention
A) take by weighing Radix Ginseng 25 grams, Herba Cistanches 25 grams, Cornu Cervi Pantotrichum 35 grams, Fructus Corni 25 grams, the Cortex Eucommiae (saline stir-fry) 25 grams, Herba Cynomorii 25 grams, Herba Epimedii 25 grams, Radix Morindae Officinalis 25 grams, Fructus Lycii 35 grams, Radix Polygoni Multiflori Preparata 35 grams, Poria 25 grams and Radix Glycyrrhizae (processed with honey) 10 grams, standby;
B) get Radix Ginseng, Fructus Lycii, Herba Cynomorii, 16 gram Poria and Radix Glycyrrhizae coarse powder, add 5 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate and concentrate concentrated solution 1, standby;
C) get Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae, Herba Epimedii, Radix Morindae Officinalis and Radix Polygoni Multiflori coarse powder, add 5 times of amount 30% alcohol heating reflux 2 times, each 2 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, and it is 1.30～1.35 concentrated solution 2 that remaining aqueous solution is concentrated into relative density;
D) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, and add 9 gram Poria fine powder and appropriate amount of auxiliary materials, be pressed into granule.
Claims (5)
1. the medicine of a kidney invigorating and YANG supporting is characterized in that it is made by following raw materials by weight proportions: 10～20 parts of 25～35 parts of Radix Ginsengs, 25～35 parts of Herba Cistanches, 35～45 parts in Cornu Cervi Pantotrichum, 25～35 parts of Fructus Corni, 25～35 parts of saline Cortex Eucommiae (parched), 25～35 parts of Herba Cynomoriis, 25～35 parts of Herba Epimedii, 25～35 parts of Radix Morindae Officinaliss, 35～45 parts of Fructus Lycii, 35～45 parts of Radix Polygoni Multiflori Preparatas, 25～35 parts in Poria and Radix Glycyrrhizae (processed with honey).
2. medicine according to claim 1, wherein the consumption of each crude drug is: 15 parts of 30 parts of Radix Ginsengs, 30 parts of Herba Cistanches, 40 parts in Cornu Cervi Pantotrichum, 30 parts of Fructus Corni, 30 parts of saline Cortex Eucommiae (parched), 30 parts of Herba Cynomoriis, 30 parts of Herba Epimedii, 30 parts of Radix Morindae Officinaliss, 40 parts of Fructus Lycii, 40 parts of Radix Polygoni Multiflori Preparatas, 30 parts in Poria and Radix Glycyrrhizae (processed with honey).
3. medicine according to claim 1 and 2, it is the pharmaceutics of Chinese drugs common formulations: capsule, soft capsule, tablet, drop pill, granule or oral liquid.
4. the preparation method of each described medicine among the claim 1-3, it may further comprise the steps:
A) take by weighing each crude drug of described weight proportion, wherein Poria was divided into two parts pulverize separately by about 2: 1 and becomes coarse powder and fine powder, and is standby;
B) get Radix Ginseng, Fructus Lycii, Herba Cynomorii, Poria and Radix Glycyrrhizae coarse powder, add 5--10 times of water gaging and decoct 2-3 time, each 1--2 hour, filter, merging filtrate and concentrated concentrated solution 1, standby;
C) get Herba Cistanches, Cornu Cervi Pantotrichum, Fructus Corni, the Cortex Eucommiae, Herba Epimedii, Radix Morindae Officinalis and Radix Polygoni Multiflori coarse powder, add 5--10 and doubly measure the 30--70% alcohol heating reflux 2-3 time, each 1-2 hour, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, and it is 1.30～1.35 that remaining aqueous solution is concentrated into relative density, get concentrated solution 2, standby;
D) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder adds the Poria fine powder, and mix homogeneously just has been prepared into the active component of medicine of the present invention.
5. according to the preparation method of the described medicine of claim 4, wherein the active component that step d) is made is mixed with appropriate amount of drug correctives and/or drug excipient, makes conventional peroral dosage form: capsule, soft capsule, drop pill, granule, tablet or oral liquid.
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| CN107669866A (en) * | 2017-11-23 | 2018-02-09 | 重庆三峡云海药业股份有限公司 | A kind of compound kidney-nourishing tcm drug capsule and preparation method thereof |
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|---|---|---|---|---|
| CN102204995B (en) * | 2011-05-26 | 2013-05-22 | 威海金颐阳药业有限公司 | Kidney-reinforcing tonic wine |
| CN102697964B (en) * | 2012-05-11 | 2014-05-28 | 贾晋科 | Medicine for treating male sexual dysfunction |
| CN103689149A (en) * | 2013-12-07 | 2014-04-02 | 郑州市康健电子产品研究所 | Kidney tonifying tea |
| CN104435528A (en) * | 2014-10-20 | 2015-03-25 | 安徽华泽医药有限公司 | Traditional Chinese medicine preparation with effects of tonifying kidney and benefiting yang |
| CN105031347A (en) * | 2015-07-29 | 2015-11-11 | 郭学敏 | Traditional Chinese medicine decoction for invigorating kidney and strengthening Yang |
| CN105343419A (en) * | 2015-11-20 | 2016-02-24 | 吴冲 | Traditional Chinese medicinal pill for invigorating yang and tonifying kidney, and preparation method thereof |
| CN105558977A (en) * | 2015-12-14 | 2016-05-11 | 青岛华之草医药科技有限公司 | Method for preparing solid mutton broth with effects of tonifying Yang and dispelling cold |
| CN107737191A (en) * | 2017-09-22 | 2018-02-27 | 内蒙古蒙肽生物工程有限公司 | The saline cistanche composition and preparation technology of a kind of kidney-tonifying health-care |
| CN110721269A (en) * | 2019-12-02 | 2020-01-24 | 宁夏宝丰生态牧场有限公司 | Chinese wolfberry composite oral liquid and preparation method thereof |
| CN111184821A (en) * | 2020-04-09 | 2020-05-22 | 胡志民 | Medicinal liquor |
| CN113750148A (en) * | 2021-07-19 | 2021-12-07 | 浙江羲和时光科技有限公司 | Chinese herbal medicine formula for treating prostatitis of middle-aged and old people |
| CN113750174A (en) * | 2021-07-20 | 2021-12-07 | 浙江羲和时光科技有限公司 | Chinese herbal medicine formula for improving male sexual function weakness |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153642A (en) * | 1995-12-07 | 1997-07-09 | 沈阳长城文化企业发展公司 | Health oral liquid |
-
2005
- 2005-11-04 CN CNB2005101175254A patent/CN100352472C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153642A (en) * | 1995-12-07 | 1997-07-09 | 沈阳长城文化企业发展公司 | Health oral liquid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669866A (en) * | 2017-11-23 | 2018-02-09 | 重庆三峡云海药业股份有限公司 | A kind of compound kidney-nourishing tcm drug capsule and preparation method thereof |
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| CN1768811A (en) | 2006-05-10 |
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