CN102038778A - Chinese medicinal composition with effects of relaxing meridians, activating collaterals, expelling wind and removing dampness and preparation method thereof - Google Patents
Chinese medicinal composition with effects of relaxing meridians, activating collaterals, expelling wind and removing dampness and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition with the effects of relaxing meridians, activating collaterals, expelling wind and removing dampness and a preparation method thereof. The composition is mainly prepared from the following raw materials in part by weight: 10 to 45 parts of east Asian tree fern rhizome, 20 to 60 parts of sargentgloryvine stem, 10 to 45 parts of Chinese taxillus twig, 10 to 45 parts of Himalayan teasel root, 10 to 45 parts of eucommia bark, 10 to 45 parts of glossy privet fruit, 10 to 45 parts of suberect spatholobus stem, 10 to 45 parts of cherokee rose fruit and 10 to 45 parts of south dodder seed. The preparation method comprises the following steps of: performing water extraction and alcohol precipitation on the medicinal materials according to the proportion, and concentrating. The Chinese medicinal composition has the effects of relaxing the meridians, activating the collaterals, lubricating joints, expelling the wind and removing the dampness, and is convenient to use, and safe and high-efficiency.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of soothing the channels and quicking the network vessels, expelling wind and removing dampness and preparation method thereof.
Background technology
Along with rapid economy development, people's rhythm of life is also accelerated day by day, but usually because pressure and the tired generation that causes arthromyodynia.Special in the crowd who bends over one's desk working for a long time, because of the same posture of long-term maintenance, cause muscular strains in shoulder region, numb limbs and tense tendons, the joint joint stuffiness, pain acid is expanded, symptoms such as fatigue is dizzy, severe patient can cause diseases such as cervical spondylosis, scapulohumeral periarthritis, can cause neck coronary heart disease, hypertension, hemiplegia, insomnia etc. what is more, has influenced work and life.The traditional Chinese medical science is on the angle of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and the meridians that these diseases belong to due to wind, the exopathogen invasion such as cold, wet are obstructed, move obstructed and arthromyodynia that cause.
Therefore, address the above problem extremely urgent.At present, the pure Chinese medicinal preparation of also effective such disease of treatment.
Summary of the invention
The object of the present invention is to provide a kind of efficient, safe soothing the channels and quicking the network vessels, expelling wind and removing dampness Chinese medicine composition.
Another object of the present invention is to provide the preparation method of this soothing the channels and quicking the network vessels, expelling wind and removing dampness Chinese medicine composition.
Solution of the present invention is mainly based on understanding and the Therapeutic Principle of motherland's medical science to arthromyodynia, with reference to the modern pharmacological research achievement, from pools of traditional Chinese medicine, filter out the good Chinese medicine of coupling therapeutic effect, by the theory of Chinese medical science prescription, effective ingredient in the side of extracting makes it reach the purpose of soothing the channels and quicking the network vessels, expelling wind and removing dampness.In addition, by standardized production preparation, make pharmacology, medicineization and drug effect standardization.
The objective of the invention is to implement in the following manner:
A kind of soothing the channels and quicking the network vessels, expelling wind and removing dampness Chinese medicine composition, this Chinese medicine composition is mainly obtained by following feedstock production:
Rhizoma Cibotii 10-45 part, Caulis Sargentodoxae 20-60 part, Herba Taxilli 10-45 part, Radix Dipsaci 10-45 part, Cortex Eucommiae 10-45 part, Fructus Ligustri Lucidi 10-45 part, Caulis Spatholobi 10-45 part, Fructus Rosae Laevigatae 10-45 part, Semen Cuscutae 10-45 part.
Above-mentioned soothing the channels and quicking the network vessels, expelling wind and removing dampness Chinese medicine composition are preferably mainly made by following weight proportioning raw material:
Rhizoma Cibotii 15-30 part, Caulis Sargentodoxae 20-40 part, Herba Taxilli 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae 15-30 part, Fructus Ligustri Lucidi 15-30 part, Caulis Spatholobi 15-30 part, Fructus Rosae Laevigatae 15-30 part, Semen Cuscutae 15-30 part.
Above-mentioned Chinese medicine composition can be prepared into unguentum, oral liquid, tablet, granule or capsule with acceptable accessories.
The preparation method of the Chinese medicine composition of soothing the channels and quicking the network vessels of the present invention, expelling wind and removing dampness may further comprise the steps:
Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae are pressed recipe quantity to be mixed, the water heating extraction of doubly measuring with total medical material 6-12 1-3 time, each 1-3 hour, filter merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 60-80 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure ethanol, make to contain the alcohol amount and be 60-70%, standing over night, filter, filtrate concentrates.
But above-mentioned Chinese medicine composition soothing the channels and quicking the network vessels, relieving rigidity of joints, expelling wind and removing dampness can be used in the medicine of preparation treatment arthromyodynia.Particularly in the medicine of preparation treatment shoulder and neck arthralgia, use and have significant effect.Shoulder and neck arthralgia shows as the strain of shoulder cervical muscle meat, upper limb joint stuffiness etc.
Above-mentioned soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum are made up of the following weight proportion raw material:
Rhizoma Cibotii 10-45 part, Caulis Sargentodoxae 20-60 part, Herba Taxilli 10-45 part, Radix Dipsaci 10-45 part, Cortex Eucommiae 10-45 part, Fructus Ligustri Lucidi 10-45 part, Caulis Spatholobi 10-45 part, Fructus Rosae Laevigatae 10-45 part, Semen Cuscutae 10-45 part, stearic acid 3-10 part, glyceryl monostearate 15-30 part, hexadeca-octadecyl alcohol 10-30 part, lanoline 10-20 part, liquid paraffin 75-120 part, vaseline 40-80 part, glycerol 50-100 part, azone 5-15 part, ethoxylation methylglucoside stearate 10-40 part, propyl p-hydroxybenzoate 1-4 part, methyl parahydroxybenzoate 1-2 part, methylglucoside stearate 5-8 part, propylene glycol 10-30 part.
Above-mentioned soothing the channels and quicking the network vessels, the expelling wind and removing dampness unguentum preferably is made up of the following weight proportion raw material: Rhizoma Cibotii 15-30 part, Caulis Sargentodoxae 20-40 part, Herba Taxilli 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae 15-30 part, Fructus Ligustri Lucidi 15-30 part, Caulis Spatholobi 15-30 part, Fructus Rosae Laevigatae 15-30 part, Semen Cuscutae 15-30 part, stearic acid 5-10 part, glyceryl monostearate 15-20 part, hexadeca-octadecyl alcohol 15-25 part, lanoline 10-20 part, liquid paraffin 90-110 part, vaseline 50-70 part, glycerol 60-80 part, azone 8-13 part, ethoxylation methylglucoside stearate 15-30 part, propyl p-hydroxybenzoate 1-2 part, methyl parahydroxybenzoate 1-2 part, methylglucoside stearate 5-8 part, propylene glycol 15-30 part.
The preparation method of soothing the channels and quicking the network vessels of the present invention, expelling wind and removing dampness Chinese medicine composition may further comprise the steps:
A, extraction: Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae are mixed the water extraction of doubly measuring with total medical material 6-12 1-3 time, each 1-3 hour with recipe quantity; Filter, merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 60-80 ℃, add concentrated solution 2-3 and doubly measure ethanol in concentrated solution, makes to contain the alcohol amount and be 60-70%, and standing over night is filtered, and obtains alcohol deposit fluid;
B, decolouring: with active carbon alcohol deposit fluid is carried out reflux decolour, decolouring finishes after-filtration and removes active carbon; At 40-80 ℃ of following concentrating under reduced pressure destaining solution to relative density 1.08-1.12;
C, get stearic acid, glyceryl monostearate, hexadeca-octadecyl alcohol, lanoline, liquid paraffin, vaseline, azone, ethoxylation methylglucoside stearate, propyl p-hydroxybenzoate, methyl parahydroxybenzoate, be heated to 93-97 ℃ after the mixing while stirring, filter, filtrate 93-97 ℃ vacuum heat-preserving 25-35 minute, wait to be cooled to 83-87 ℃ and get oil phase, be incubated standby;
D, get the Chinese medicine concentrated solution that methylglucoside stearate, glycerol, propylene glycol and " b " step obtain and mix, be heated to 93-97 ℃ while stirring, be incubated 25-35 minute, filtered while hot, when waiting to be cooled to 83-87 ℃, add the oil phase that standby " c " step of insulation obtains, the formation mastic stirs.
Described decolouring for active carbon to alcohol deposit fluid by 1% (W/V) measure (being that the 100mL alcohol deposit fluid adds the 1g active carbon) carry out reflux decolour processing 1-2 hour (active carbon with preceding more than 80 ℃ baking oven for heating be no less than 4 hours), note mix homogeneously when active carbon mixes with alcohol deposit fluid, otherwise decolorizing effect can be influential; Decolouring finishes after-filtration, guarantees the active carbon removal fully.
The using method of unguentum of the present invention: rub with the hands even in the palm of at first unguentum being let go, be applied to the position such as shoulder neck, back of health, crumple back and forth with palm, and emphasis is pressed the acupuncture point relevant with treating arthromyodynia, as take on neck, Tian Zong, chien cheng, wind pond, windy mansion etc., active ingredient of drugs is infiltrated in the body, play the effect of treatment, each 20g carried out 30-60 minute at every turn, 1 time on the one or the next day 1 time, 6 times is a course of treatment, can obviously feel that sx, meridian energy value raise and near normal, effective percentage can be up to more than 95% after 2 courses of treatment 1 course of treatment.Can be better with soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum in conjunction with meridians massage effect, for the arthromyodynia crowd provides the specialty conditioning, particularly cause muscular strains in shoulder region for reason such as bend over one's desk working for a long time, upper limb numbness, the joint joint stuffiness, pain acid is expanded, and tired symptom effect such as dizzy is very remarkable.
In the raw material of Chinese medicine prescription, Rhizoma Cibotii is the dry rhizome of Dicksoniaceae plant Rhizoma Cibotii Cibotium barometz (L.) J.Sm..The Rhizoma Cibotii wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Be used for anemofrigid-damp arthralgia, soreness of the waist and knees, weakness of the lower extremities etc.Caulis Sargentodoxae is the dry rattan of Lardizabalaceae plant Caulis Sargentodoxae Sargentodoxa cuneata (Oliv.) Rehd.Et wils..Claim Caulis Sargentodoxae again.The Caulis Sargentodoxae heat-clearing and toxic substances removing is invigorated blood circulation, and dispels the wind pain relieving.Be used for abdominalgia with intestinal abscess, traumatic injury, rheumatic arthralgia.Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.The Herba Taxilli wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for rheumatic Bi syndrome, metrorrhagia is through many etc.Radix Dipsaci is the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperodies C.Y.Cheng et T.M.Ai..The Radix Dipsaci liver and kidney tonifying, strengthening the tendons and bones, arresting bleeding and miscarriage prevention, the continuous folding of curing the wound.Radix Dipsaci is used for sexual impotence erectile problem, soreness of waist and knee joint, arthralgia due to cold-dampnes, metrostaxis, traumatic injury.The Cortex Eucommiae is the bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoodes Oliv..Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency and various lumbago, frequent fetal movement.Fructus Ligustri Lucidi is the mature fruit of Oleaceae plant Fructus Ligustri Lucidi Ligustrum lucidum Ait..The Fructus Ligustri Lucidi nourishing the liver and kidney, crow must make eye bright.Fructus Ligustri Lucidi is used for syndrome of yin deficiency of liver and kidney.Caulis Spatholobi is a leguminous plant honey HUADOU Spatholobus suberectus Dunn ratan.The Caulis Spatholobi promoting the circulation of blood is enriched blood, regulating menstruation, soothing the channels and quicking the network vessels.Caulis Spatholobi is used for menoxenia, rheumatic arthralgia, numb hand and foot etc.Fructus Rosae Laevigatae is the mature fruit of rosaceous plant Fructus Rosae Laevigatae Rosa laevigata Michx..Fructus Rosae Laevigatae controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping, relieving diarrhea with astringents.Fructus Rosae Laevigatae is used for emission and spermatorrhea, chronic diarrhea chronic dysentery etc.Semen Cuscutae is the mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..The Semen Cuscutae the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antidiarrheal, antiabortive.Semen Cuscutae is used for lumbago due to renal deficiency, frequent micturition, deficiency of the liver and kindey, poor vision, deficiency of spleen-YANG and kidneyYANG etc.
The side separates: we institute control be seek, defend, gas, blood imbalance or (QI and blood) lose empty, due to wind, exopathogen such as cold, wet are invaded.Wind, exopathogen invasion such as cold, wet can cause numb limbs and tense tendons, the joint joint stuffiness, and pain acid is expanded, tired symptom such as dizzy.In the event side with Rhizoma Cibotii, Herba Taxilli, the Cortex Eucommiae, Caulis Sargentodoxae expelling wind and removing dampness, channels sootheing and network vessel quickening, relieving rigidity of joints, liver and kidney tonifying.Invigorate blood circulation with Radix Dipsaci, Semen Cuscutae, Caulis Spatholobi, dispel the wind, relieving spasm to stop pain.With Fructus Rosae Laevigatae, Fructus Ligustri Lucidi invigorating the liver and kidney.We's medication, with the meridian dredging that relaxes, relieving rigidity of joints, expelling wind and removing dampness is main, and compatibility tonification, the crystalline substance of invigorating blood circulation are dredged and are supported combination, and heresy is just taken into account, and plays wind-damp dispelling altogether, the effect of the meridian dredging.
Beneficial effect of the present invention compared with the prior art: Chinese medicine composition of the present invention has the effect of soothing the channels and quicking the network vessels, relieving rigidity of joints, expelling wind and removing dampness, can be to arthromyodynia, muscular strain due to the bad or wind of posture, the exopathogen invasion such as cold, wet particularly, numb limbs and tense tendons, the joint joint stuffiness, pain acid is expanded, and tired symptom such as dizzy is treated, effect is remarkable, and safe in utilization, convenient.
In order to prove the effect and the safety of soothing the channels and quicking the network vessels of the present invention, expelling wind and removing dampness Chinese medicine composition, be made into soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum (preparing) according to embodiment 1 method, carried out dermatologic irritant experiment, toxicological experiment and curative effect checking, its experimental data is specific as follows:
1, irritant experiment
A, experiment material:
Medicine: prepare according to embodiment 1 method
Animal: Cavia porcellus is provided by China Medicine University's Experimental Animal Center
B, experimental technique:
Get six of Cavia porcelluss, body weight 250 ± 20 grams, male and female half and half.With Cavia porcellus spinal column both sides unhairing, the unhairing district was 8*5cm in preceding 24 hours of administration
2, checked in 24 hours after the unhairing, injured to guarantee that skin of unhairing does not have.
Adopt self contrast of leaning to one side about consubstantiality, unhairing district in left side is coated with and is subjected to reagent thing 1g (preparing according to embodiment 1 method), and the right side is coated with 1g vaseline in contrast, adds gauze, immobilization with adhesive tape with thin film.Every Cavia porcellus sub-cage rearing, be subjected to reagent after 24 hours, be subjected to reagent with the warm water flush away is residual, removal is subjected to perusal in 1,24,48,72 hour and histopathologic examination behind the reagent thing, and record is smeared the position and is had or not situations such as erythema and edema, mark, write down the score value and the recovery situation in each time, observe zest intensity intact skin.
Table 1 is subjected to reagent thing and the remedium constituens stimulation situation to intact skin
Get 6 of Cavia porcelluss, body weight 250 ± 20 grams, male and female half and half.With Cavia porcellus spinal column both sides unhairing, the unhairing district was 8*5cm in preceding 24 hours of administration
2, the unhairing district skin after will sterilizing with " # " with scalpel scratches, the degree of being with the oozing of blood, left and right sides skin by the damaged degree basically identical.
Adopt self contrast of leaning to one side about consubstantiality, unhairing district in left side is coated with and is subjected to reagent thing 1g, and the right side is coated with 1g vaseline in contrast, adds gauze, immobilization with adhesive tape with thin film.Every Cavia porcellus sub-cage rearing, be subjected to the reagent thing after 24 hours, with the residual reagent thing that is subjected to of warm water flush away, removal is subjected to perusal in 1,24,48,72 hour and histopathologic examination behind the reagent thing, and record is smeared the position and is had or not erythema and edema situation, mark, write down the score value and the recovery situation in each time, observe stimulation situation damaged skin
Table 2 is subjected to reagent thing and the remedium constituens stimulation situation to damaged skin
2, toxicological experiment
A, animal acute toxicity test
Acute toxicity test in mice studies show that medicine of the present invention (preparing according to embodiment 4 methods) gastric infusion can't be measured LD
50Use instead and irritate the test of stomach maximum dosage-feeding.The result shows: press Cmax, maximum volume, one day at every turn and irritate stomach twice, the maximum dosage-feeding of mice administration is 342g crude drug/kg (is equivalent to intend clinical application 855 times), does not have tangible toxic reaction, observes no animal dead in the week.
B, long-term toxicity test for animals
Medicine 18,9 of the present invention and 3g/kg (in the crude drug amount, being equivalent to intend 60,30 and 10 times of clinical consumption) three dosage groups and blank groups are established in test, adopt the gastric infusion approach to give rat respectively, successive administration 6 months.Observe general situation features such as the appetite respectively organize rat, body weight, outward appearance sign,, carry out hematology, blood parameters and pathological examination respectively in administration 3 months, 6 months and convalescent period.The result shows: medicine of the present invention is to the not obviously influence of animal general signs, and administration 3 months, 6 months removes high dose group minority rats'liver to take a favourable turn-the moderate necrosis, the inflammation pathological change, zero difference between female, the tom.After the drug withdrawal 21 days, high dose group was respectively examined the internal organs pathology of livers and is alleviated, with blank group no significant difference relatively.Show to be the nontoxic amounts of reactants of rat less than 9g/kg.
3, efficacy experiment
100 examples had muscular strains in shoulder region, upper limb numbness, the joint joint stuffiness, pain acid is expanded, the tired dizzy sub-health population of shoulder and neck arthralgia symptom that waits carries out clinical treatment with this soothing the channels and quicking the network vessels, expelling wind and removing dampness Chinese medicine composition in conjunction with massage, adopts vaseline to massage to combine to treat with 20 examples of matched group simultaneously and compares.The results are shown in Table 1.
In 100 examples of treatment group: male, each 50 example of women, stadium is the shortest 3 months, and is the longest 30 years.
In 20 examples of matched group: male, each 10 example of women, stadium is the shortest 5 months, and is the longest 21 years.
Show according to clinical trial, Chinese medicine composition of the present invention (preparing) according to embodiment 1 method use continuously 1 course of treatment (each 20g carried out 30-60 minute at every turn, 1 time on the one or the next day 1 time, totally 6 times), total effective rate reaches 85%; Use 2 courses of treatment (12 times) continuously, total effective rate reaches 96%.
Criterion is as follows:
Efficiently: the shoulder tuberosity disappears, and shoulder joint is ached to feel and disappeared, tired dizzy, upper limb numbness transference cure;
Produce effects: the shoulder tuberosity disappears substantially, this disappearance of joint aches sensillary base, and fatigue is dizzy, the upper limb numbness symptom disappears substantially;
Effectively: the shoulder tuberosity, joint aches, tired dizzy, upper limb numbness all has improvement;
Invalid: the shoulder tuberosity does not have to change substantially, joint aches, tired dizzy, and this does not eliminate the upper limb numbness sensillary base.
Table 1 is subjected to the clinical trial situation of examination group and matched group
Above-mentioned evidence, the present invention prescription can wind-damp dispelling, bone and muscle strengthening, and invigorating the liver and kidney, and non-stimulated to skin in using has safety non-toxic, characteristics evident in efficacy.
The specific embodiment
Embodiment 1
A kind of soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum, it is to be made by following weight proportioning raw material:
25 parts of 30 parts of Herba Taxillis of 25 portions of Caulis Sargentodoxaes of Rhizoma Cibotii
25 parts of 25 parts of Fructus Ligustri Lucidi of 25 parts of Cortexs Eucommiae of Radix Dipsaci
25 parts of 25 parts of Semen Cuscutae of 25 portions of Fructus Rosae Laevigatae of Caulis Spatholobi
20 parts of 17 parts of hexadeca-octadecyl alcohols of 6 parts of glyceryl monostearates of stearic acid
10 parts of 100 parts of azones of 15 parts of liquid paraffin of lanoline
1 part of 2 parts of methyl parahydroxybenzoate of 25 parts of propyl p-hydroxybenzoate of ethoxylation methylglucoside stearate
70 parts of 20 parts of glycerol of 6 parts of propylene glycol of methylglucoside stearate
60 parts in vaseline
The preparation method of above-mentioned soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum is according to following steps:
A, get Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae according to aforementioned proportion, with the water heating extraction of 10 times of amounts of total medical material 2 times, each 2 hours, filter, merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 70 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure 95% ethanol, make to contain the alcohol amount, stir evenly standing over night for 60-70%.Filter, obtain alcohol deposit fluid; With medical activated carbon to alcohol deposit fluid by 1% (W/V) measure (being that the 100mL alcohol deposit fluid adds the 1g active carbon) carry out reflux decolouring handle 1 hour (active carbon with preceding more than 80 ℃ baking oven for heating be no less than 4 hours); To relative density 1.10, obtain the Chinese medicine concentrated solution at 60 ℃ of following concentrating under reduced pressure destaining solution;
B, get stearic acid, glyceryl monostearate, hexadeca-octadecyl alcohol, lanoline, liquid paraffin, vaseline, azone, ethoxylation methylglucoside stearate, propyl p-hydroxybenzoate, methyl parahydroxybenzoate according to aforementioned proportion, after the mixing, be heated to 93 ℃ while stirring, filter, 93 ℃ of vacuum heat-preservings of filtrate 25 minutes, wait to be cooled to 83 ℃ and get oil phase, be incubated standby;
C, get methylglucoside stearate, glycerol, propylene glycol according to aforementioned proportion and mix with the Chinese medicine concentrated solution that " a " step obtains, be heated to 93 ℃ while stirring, be incubated 25 minutes, filtered while hot, when waiting to be cooled to 83 ℃, add the oil phase that standby " b " step of insulation obtains, the formation mastic stirs.
Embodiment 2
A kind of soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum, it is to be made by following weight proportioning raw material:
40 parts of 60 parts of Herba Taxillis of 40 portions of Caulis Sargentodoxaes of Rhizoma Cibotii
40 parts of 40 parts of Fructus Ligustri Lucidi of 40 parts of Cortexs Eucommiae of Radix Dipsaci
40 parts of 40 parts of Semen Cuscutae of 40 portions of Fructus Rosae Laevigatae of Caulis Spatholobi
30 parts of 30 parts of hexadeca-octadecyl alcohols of 10 parts of glyceryl monostearates of stearic acid
15 parts of 110 parts of azones of 20 parts of liquid paraffin of lanoline
2 parts of 4 parts of methyl parahydroxybenzoate of 35 parts of propyl p-hydroxybenzoate of ethoxylation methylglucoside stearate
80 parts of 25 parts of glycerol of 8 parts of propylene glycol of methylglucoside stearate
80 parts in vaseline
The preparation method of above-mentioned soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum is according to following steps:
A, get Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae according to aforementioned proportion, with the water heating extraction of 8 times of amounts of total medical material 1 time, each 3 hours, filter, merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 80 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure 95% ethanol, make to contain the alcohol amount, stir evenly standing over night for 60-70%.Filter, obtain alcohol deposit fluid; With medical activated carbon to alcohol deposit fluid by 1% (W/V) measure (being that the 100mL alcohol deposit fluid adds the 1g active carbon) carry out reflux decolouring handle 2 hours (active carbon with preceding more than 80 ℃ baking oven for heating be no less than 4 hours); To relative density 1.08, obtain the Chinese medicine concentrated solution at 60 ℃ of following concentrating under reduced pressure destaining solution;
B, get stearic acid, glyceryl monostearate, hexadeca-octadecyl alcohol, lanoline, liquid paraffin, vaseline, azone, ethoxylation methylglucoside stearate, propyl p-hydroxybenzoate, methyl parahydroxybenzoate according to aforementioned proportion, after the mixing, be heated to 96 ℃ while stirring, filter, 96 ℃ of vacuum heat-preservings of filtrate 30 minutes, wait to be cooled to 85 ℃ and get oil phase, be incubated standby;
C, get methylglucoside stearate, glycerol, propylene glycol according to aforementioned proportion and mix with the Chinese medicine concentrated solution that " a " step obtains, be heated to 96 ℃ while stirring, be incubated 30 minutes, filtered while hot, when waiting to be cooled to 85 ℃, add the oil phase that standby " b " step of insulation obtains, the formation mastic stirs.
Embodiment 3
A kind of soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum, it is to be made by following weight proportioning raw material:
10 parts of 40 parts of Herba Taxillis of 10 portions of Caulis Sargentodoxaes of Rhizoma Cibotii
10 parts of 10 parts of Fructus Ligustri Lucidi of 10 parts of Cortexs Eucommiae of Radix Dipsaci
10 parts of 10 parts of Semen Cuscutae of 10 portions of Fructus Rosae Laevigatae of Caulis Spatholobi
15 parts of 15 parts of hexadeca-octadecyl alcohols of 5 parts of glyceryl monostearates of stearic acid
5 parts of 90 parts of azones of 10 parts of liquid paraffin of lanoline
1 part of 1 part of methyl parahydroxybenzoate of 10 parts of propyl p-hydroxybenzoate of ethoxylation methylglucoside stearate
50 parts of 10 parts of glycerol of 5 parts of propylene glycol of methylglucoside stearate
40 parts in vaseline
The preparation method of above-mentioned soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum is according to following steps:
A, get Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae according to aforementioned proportion, with the water heating extraction of 12 times of amounts of total medical material 3 times, each 1 hour, filter, merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 60 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure 95% ethanol, make to contain the alcohol amount, stir evenly standing over night for 60-70%.Filter, obtain alcohol deposit fluid; With medical activated carbon to alcohol deposit fluid by 1% (W/V) measure (being that the 100mL alcohol deposit fluid adds the 1g active carbon) carry out reflux decolouring handle 1 hour (active carbon with preceding more than 80 ℃ baking oven for heating be no less than 4 hours); To relative density 1.12, obtain the Chinese medicine concentrated solution at 80 ℃ of following concentrating under reduced pressure destaining solution;
B, get stearic acid, glyceryl monostearate, hexadeca-octadecyl alcohol, lanoline, liquid paraffin, vaseline, azone, ethoxylation methylglucoside stearate, propyl p-hydroxybenzoate, methyl parahydroxybenzoate according to aforementioned proportion, after the mixing, be heated to 97 ℃ while stirring, filter, 97 ℃ of vacuum heat-preservings of filtrate 35 minutes, wait to be cooled to 87 ℃ and get oil phase, be incubated standby;
C, get methylglucoside stearate, glycerol, propylene glycol according to aforementioned proportion and mix with the Chinese medicine concentrated solution that " a " step obtains, be heated to 97 ℃ while stirring, be incubated 35 minutes, filtered while hot, when waiting to be cooled to 87 ℃, add the oil phase that standby " b " step of insulation obtains, the formation mastic stirs.
Embodiment 4
Get 30 parts of Rhizoma Cibotii, 40 parts of Caulis Sargentodoxaes, 30 parts of Herba Taxillis, 30 parts of Radix Dipsacis, 30 parts of the Cortexs Eucommiae, 30 parts of Fructus Ligustri Lucidi, 30 parts of Caulis Spatholobis, 30 parts of Fructus Rosae Laevigatae, 30 parts of Semen Cuscutae, with above-mentioned medical material, with the water heating extraction of 10 times of amounts of total medical material 2 times, each 2 hours, filter, merging filtrate, filtrate, adds concentrated solution 2-3 and doubly measures 95% ethanol to relative density 1.05-1.10 at 70 ℃ of following concentrated extracting solution in concentrated solution, make to contain the alcohol amount and be 60-70%, stir evenly standing over night.Filter, obtain alcohol deposit fluid; Under 60 ℃, be evaporated to the extractum that relative density is 1.25-1.30; With 70 ℃ of dried cream of vacuum drying of extractum, be ground into fine powder, adding starch is an amount of, and mix homogeneously is made soft material in right amount with 70% ethanol, granulates, 70 ℃ of dryings, granulate promptly gets granule.
Embodiment 5
Get 15 parts of Rhizoma Cibotii, 20 parts of Caulis Sargentodoxaes, 15 parts of Herba Taxillis, 15 parts of Radix Dipsacis, 15 parts of the Cortexs Eucommiae, 15 parts of Fructus Ligustri Lucidi, 15 parts of Caulis Spatholobis, 15 parts of Fructus Rosae Laevigatae, 15 parts of Semen Cuscutae, with above-mentioned medical material, with the water heating extraction of 10 times of amounts of total medical material 2 times, each 2 hours, filter, merging filtrate, filtrate, adds concentrated solution 2-3 and doubly measures 95% ethanol to relative density 1.05-1.10 at 70 ℃ of following concentrated extracting solution in concentrated solution, make to contain the alcohol amount and be 60-70%, stir evenly standing over night.Filter, obtain alcohol deposit fluid; Under 60 ℃, be evaporated to the extractum that relative density is 1.25-1.30; With 80 ℃ of dried cream of vacuum drying of extractum, be ground into fine powder, adding starch is an amount of, and mix homogeneously is made soft material in right amount with 70% ethanol, granulates, 80 ℃ of dryings, granulate adds 0.5% magnesium stearate, mix homogeneously, filled capsules makes capsule.
Embodiment 6
Get 40 parts of Rhizoma Cibotii, 55 parts of Caulis Sargentodoxaes, 40 parts of Herba Taxillis, 40 parts of Radix Dipsacis, 45 parts of the Cortexs Eucommiae, 45 parts of Fructus Ligustri Lucidi, 45 parts of Caulis Spatholobis, 45 parts of Fructus Rosae Laevigatae, 45 parts of Semen Cuscutae, with above-mentioned medical material, with the water heating extraction of 10 times of amounts of total medical material 2 times, each 2 hours, filter, merging filtrate, filtrate, adds concentrated solution 2-3 and doubly measures 95% ethanol to relative density 1.05-1.10 at 70 ℃ of following concentrated extracting solution in concentrated solution, make to contain the alcohol amount and be 60-70%, stir evenly standing over night.Filter, obtain alcohol deposit fluid; Under 60 ℃, be evaporated to the extractum that relative density is 1.25-1.30; With 60 ℃ of dried cream of vacuum drying of extractum, be ground into 100 order fine powders, adding starch is an amount of, and mix homogeneously is made soft material in right amount with 70% ethanol, granulates, and 60 ℃ of dryings are pressed the compacting of tablet common process in flakes.
Embodiment 7
Get 20 parts of Rhizoma Cibotii, 30 parts of Caulis Sargentodoxaes, 20 parts of Herba Taxillis, 20 parts of Radix Dipsacis, 20 parts of the Cortexs Eucommiae, 20 parts of Fructus Ligustri Lucidi, 20 parts of Caulis Spatholobis, 20 parts of Fructus Rosae Laevigatae, 20 parts of Semen Cuscutae, with above-mentioned medical material, with the water heating extraction of 8 times of amounts of total medical material 3 times, each 2 hours, filter, merging filtrate, filtrate, adds concentrated solution 2-3 and doubly measures 95% ethanol to relative density 1.05-1.10 at 70 ℃ of following concentrated extracting solution in concentrated solution, make to contain the alcohol amount and be 60-70%, stir evenly standing over night.Filter, obtain alcohol deposit fluid; Under 60 ℃, be evaporated to the extractum that relative density is 1.25-1.30; Extractum≤60 ℃ vacuum drying to dried cream, is ground into fine powder, adds conventional adjuvant, make pill.
Embodiment 8
Get 15 parts of Rhizoma Cibotii, 50 parts of Caulis Sargentodoxaes, 15 parts of Herba Taxillis, 15 parts of Radix Dipsacis, 15 parts of the Cortexs Eucommiae, 15 parts of Fructus Ligustri Lucidi, 15 parts of Caulis Spatholobis, 15 parts of Fructus Rosae Laevigatae, 15 parts of Semen Cuscutae, with above-mentioned medical material, with the water heating extraction of 12 times of amounts of total medical material 1 time, 2 hours extraction times, filter, merging filtrate, filtrate, adds concentrated solution 2-3 and doubly measures 95% ethanol to relative density 1.05-1.10 at 70 ℃ of following concentrated extracting solution in concentrated solution, make to contain the alcohol amount and be 60-70%, stir evenly standing over night.Filter, obtain alcohol deposit fluid; Under 60 ℃, be evaporated to the extractum that relative density is 1.25-1.30; Extractum≤60 ℃ vacuum drying to dried cream, is ground into fine powder, and conventional preparation technology makes oral liquid by oral liquid.
Claims (10)
1. the Chinese medicine composition of a soothing the channels and quicking the network vessels, expelling wind and removing dampness is characterized in that this Chinese medicine composition is mainly obtained by following feedstock production:
Rhizoma Cibotii 10-45 part, Caulis Sargentodoxae 20-60 part, Herba Taxilli 10-45 part, Radix Dipsaci 10-45 part, Cortex Eucommiae 10-45 part, Fructus Ligustri Lucidi 10-45 part, Caulis Spatholobi 10-45 part, Fructus Rosae Laevigatae 10-45 part, Semen Cuscutae 10-45 part.
2. Chinese medicine composition according to claim 1 is characterized in that this Chinese medicine composition is mainly obtained by following feedstock production:
Rhizoma Cibotii 15-30 part, Caulis Sargentodoxae 20-40 part, Herba Taxilli 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae 15-30 part, Fructus Ligustri Lucidi 15-30 part, Caulis Spatholobi 15-30 part, Fructus Rosae Laevigatae 15-30 part, Semen Cuscutae 15-30 part.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that this Chinese medicine composition is prepared into unguentum, oral liquid, tablet, granule, pill or capsule.
4. the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that this method may further comprise the steps:
Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae are pressed recipe quantity to be mixed, the water heating extraction of doubly measuring with total medical material 6-12 1-3 time, each 1-3 hour, filter merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 60-80 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure ethanol, make to contain the alcohol amount and be 60-70%, standing over night, filter, filtrate concentrates.
5. claim 1 or the 2 described Chinese medicine compositions application in the medicine of preparation soothing the channels and quicking the network vessels, relieving rigidity of joints, expelling wind and removing dampness.
6. the application of Chinese medicine composition according to claim 5 in the medicine of preparation treatment arthromyodynia, particularly shoulder and neck arthralgia.
7. the described soothing the channels and quicking the network vessels of claim 3, expelling wind and removing dampness unguentum is characterized in that this unguentum is made up of the following weight proportion raw material:
Rhizoma Cibotii 10-45 part, Caulis Sargentodoxae 20-60 part, Herba Taxilli 10-45 part, Radix Dipsaci 10-45 part, Cortex Eucommiae 10-45 part, Fructus Ligustri Lucidi 10-45 part, Caulis Spatholobi 10-45 part, Fructus Rosae Laevigatae 10-45 part, Semen Cuscutae 10-45 part, stearic acid 3-10 part, glyceryl monostearate 15-30 part, hexadeca-octadecyl alcohol 10-30 part, lanoline 10-20 part, liquid paraffin 75-120 part, vaseline 40-80 part, glycerol 50-100 part, azone 5-15 part, ethoxylation methylglucoside stearate 10-40 part, propyl p-hydroxybenzoate 1-4 part, methyl parahydroxybenzoate 1-2 part, methylglucoside stearate 5-8 part, propylene glycol 10-30 part.
8. soothing the channels and quicking the network vessels according to claim 7, the expelling wind and removing dampness unguentum is characterized in that this unguentum is made up of the following weight proportion raw material: Rhizoma Cibotii 15-30 part, Caulis Sargentodoxae 20-40 part, Herba Taxilli 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae 15-30 part, Fructus Ligustri Lucidi 15-30 part, Caulis Spatholobi 15-30 part, Fructus Rosae Laevigatae 15-30 part, Semen Cuscutae 15-30 part, stearic acid 5-10 part, glyceryl monostearate 15-20 part, hexadeca-octadecyl alcohol 15-25 part, lanoline 10-20 part, liquid paraffin 90-110 part, vaseline 50-70 part, glycerol 60-80 part, azone 8-13 part, ethoxylation methylglucoside stearate 15-30 part, propyl p-hydroxybenzoate 1-2 part, methyl parahydroxybenzoate 1-2 part, methylglucoside stearate 5-8 part, propylene glycol 15-30 part.
9. the preparation method of claim 7 or 8 described soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum is characterized in that this method may further comprise the steps:
A, Rhizoma Cibotii, Caulis Sargentodoxae, Herba Taxilli, Radix Dipsaci, the Cortex Eucommiae, Fructus Ligustri Lucidi, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Cuscutae are mixed with recipe quantity, the water heating extraction of doubly measuring with total medical material 6-12 1-3 time, each 1-3 hour, filter merging filtrate, filtrate is concentrated into relative density 1.05-1.10 under 60-80 ℃, in concentrated solution, add concentrated solution 2-3 and doubly measure ethanol, make to contain the alcohol amount and be 60-70%, standing over night, filter, obtain alcohol deposit fluid;
B, with active carbon alcohol deposit fluid is carried out reflux decolour, decolouring finishes after-filtration and removes active carbon, at 40-80 ℃ of following concentrating under reduced pressure destaining solution to relative density 1.08-1.12;
C, get stearic acid, glyceryl monostearate, hexadeca-octadecyl alcohol, lanoline, liquid paraffin, vaseline, azone, ethoxylation methylglucoside stearate, propyl p-hydroxybenzoate, methyl parahydroxybenzoate, be heated to 93-97 ℃ after the mixing while stirring, filter, filtrate 93-97 ℃ vacuum heat-preserving 25-35 minute, wait to be cooled to 83-87 ℃ and get oil phase, be incubated standby;
D, get the Chinese medicine concentrated solution that methylglucoside stearate, glycerol, propylene glycol and " b " step obtain and mix, be heated to 93-97 ℃ while stirring, be incubated 25-35 minute, filtered while hot, when waiting to be cooled to 83-87 ℃, add the oil phase that standby " c " step of insulation obtains, the formation mastic stirs.
10. the using method of claim 7 or 8 described soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum is characterized in that soothing the channels and quicking the network vessels, expelling wind and removing dampness unguentum are massaged in conjunction with meridians, for the arthromyodynia crowd provides the specialty conditioning.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977128A (en) * | 2014-05-17 | 2014-08-13 | 吕怀霞 | Traditional Chinese medicine composition for treating postoperative lumbar spinal stenosis |
| CN106267114A (en) * | 2016-09-30 | 2017-01-04 | 赵雪霞 | Remove rheumatism, the medicine for external use and preparation method thereof of soothing the channels and quicking the network vessels |
| CN108403872A (en) * | 2018-05-07 | 2018-08-17 | 深圳润邦之家生物科技有限公司 | A kind of dispeling wind and dehumidification is dispelled pain herbal essences liquid |
| CN114652769A (en) * | 2022-05-10 | 2022-06-24 | 辽宁格林希尔医疗科技有限公司 | Target medicine-introduced plaster for treating pain and dispelling wind |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679802A (en) * | 2005-01-21 | 2005-10-12 | 叶耀良 | Preparation of strengthening waist and health-caring kidney and its making method |
| CN1748739A (en) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | Muscle relaxing waist strengthening preparation and new preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1679802A (en) * | 2005-01-21 | 2005-10-12 | 叶耀良 | Preparation of strengthening waist and health-caring kidney and its making method |
| CN1748739A (en) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | Muscle relaxing waist strengthening preparation and new preparing method |
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| 《河南中医》 20100228 郑荣林 龙马二蛇酒内服外用治疗腰椎骨质增生症36例 164 1-10 第30卷, 第2期 * |
| 《河南中医》 20100228 郑荣林 龙马二蛇酒内服外用治疗腰椎骨质增生症36例 164 1-10 第30卷, 第2期 2 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977128A (en) * | 2014-05-17 | 2014-08-13 | 吕怀霞 | Traditional Chinese medicine composition for treating postoperative lumbar spinal stenosis |
| CN103977128B (en) * | 2014-05-17 | 2016-05-18 | 吕怀霞 | The Chinese medicine composition of lumbar spinal stenosis after a kind of iatrotechnics |
| CN106267114A (en) * | 2016-09-30 | 2017-01-04 | 赵雪霞 | Remove rheumatism, the medicine for external use and preparation method thereof of soothing the channels and quicking the network vessels |
| CN108403872A (en) * | 2018-05-07 | 2018-08-17 | 深圳润邦之家生物科技有限公司 | A kind of dispeling wind and dehumidification is dispelled pain herbal essences liquid |
| CN108403872B (en) * | 2018-05-07 | 2021-05-18 | 深圳润邦之家生物科技有限公司 | Herbal essence capable of dispelling wind, removing dampness and relieving pain |
| CN114652769A (en) * | 2022-05-10 | 2022-06-24 | 辽宁格林希尔医疗科技有限公司 | Target medicine-introduced plaster for treating pain and dispelling wind |
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| CN102038778B (en) | 2012-07-25 |
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