CN101181441A - Medicine for treating premature ovarian failure and preparation process thereof - Google Patents
Medicine for treating premature ovarian failure and preparation process thereof Download PDFInfo
- Publication number
- CN101181441A CN101181441A CNA2007101868632A CN200710186863A CN101181441A CN 101181441 A CN101181441 A CN 101181441A CN A2007101868632 A CNA2007101868632 A CN A2007101868632A CN 200710186863 A CN200710186863 A CN 200710186863A CN 101181441 A CN101181441 A CN 101181441A
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- China
- Prior art keywords
- medicine
- ovarian failure
- premature ovarian
- chinese medicine
- treatment
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003814 drug Substances 0.000 title claims abstract description 28
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 title claims abstract description 8
- 206010036601 premature menopause Diseases 0.000 title claims abstract description 8
- 208000017942 premature ovarian failure 1 Diseases 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 229940079593 drug Drugs 0.000 title description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- 239000007902 hard capsule Substances 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 238000009835 boiling Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 230000002611 ovarian Effects 0.000 abstract description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 abstract 1
- 241000234276 Curculigo Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 238000010792 warming Methods 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010030247 Oestrogen deficiency Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940035811 conjugated estrogen Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 description 1
- 229960004616 medroxyprogesterone Drugs 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a medicament for treating premature ovarian failure and process for preparation, wherein the raw materials include fleece flower root (prepared), cuttlebone, curculigo rhizome, epimeddium and Cinnamomum cassia bark through steps of proportioning, grilling, drying, sterilizing and filling into hard capsules. The medicine of the invention can warm and tonify kidney yang and recover the ovarian function of women, and has convenient administration and no side effect.
Description
The present invention relates to a kind of Chinese patent medicine for the treatment of premature ovarian failure, is the Chinese patent medicine of feedstock production with Chinese medicine specifically, the invention still further relates to the preparation method of this medicine.
Premature ovarian failure be meant the women 40 years old with preceding because of certain reason causes amenorrhea, infertile, estrogen deficiency, and the promoting sexual gland hormone level raises and to be a kind of disease of feature.Sickness rate is in rising trend in recent years.The gonadal hormone alternative medicine is used in treatment always clinically, but curative effect owes desirable, and untoward reaction is bigger.Through the clinical experience in 40 years, think that women's ovary senilism belongs to kidney yang and loses due to the void in person.
The present invention is a kind of compound Chinese medicinal preparation and preparation technology thereof, and its raw material is made up of Radix Polygoni Multiflori (system), Endoconcha Sepiae, Rhizoma Curculiginis, Herba Epimedii, Cortex Cinnamomi.Each component is Radix Polygoni Multiflori (system) 20% by weight ratio, Endoconcha Sepiae 25%, Rhizoma Curculiginis 20%, Herba Epimedii 20%, Cortex Cinnamomi 15%.Its preparation technology is: 1, insert above-mentioned Chinese medicine of the five flavours earlier in the medicine pot, 3 times of water yields that add the five kinds of Chinese medicine gross weight decoct, and to boiling back 20 minutes, it is standby to take concoction from fire; 2,2 times of water yields that add former five kinds of Chinese medicine gross weight on medicinal residues are carried out the 2nd decoction, and to boiling back 20 minutes Zhongli's fire, it is standby to take concoction.3, with the medicine juice of twice decoction through mix, filter, remove slag, drying, insert hard capsule after the sterilization and form.
The present invention presses the Chinese medicine principle, Radix Polygoni Multiflori (system) invigorating the liver and kidney benefiting essence-blood, and Endoconcha Sepiae convergence controlling nocturnal emission with astringent drugs, Rhizoma Curculiginis Herba Epimedii warming the kidney to invigorate YANG, the Cortex Cinnamomi promoting the flow of QI-blood by warming the meridian, to mend fire supporing yang.All medicines cooperate, and play warming and recuperating the kidney-YANG, recover the effect of ovarian function.I am diagnosis and treatment premature ovarian failure patient totally 45 examples for many years, are divided into treatment at random and organize 30 examples, matched group 15 examples.All patients all meet traditional Chinese medical science kidney yang and lose empty dialectical; Amenorrhea more than 4 months appears before the treatment, and with the symptom of perimenopausal syndrome; Repeatedly check result is pointed out serum FSH＞40IU/L.Treatment group patient every day oral invention side finished product 20 gram, with 30 days be a course of treatment, 4 courses of treatment of logotype.Matched group adopts artificial periodic method, takes conjugated estrogens 0.625mg/d, and logotype 21 days added and to use medroxyprogesterone 6mg/d in back 10 days, treats after the drug withdrawal menstrual onset the 5th day, and the same again medication treatment is treated 4 menstrual cycle altogether.Curative effect is judged: menstrual onset, keep 3 above menorrheas of cycle, and clinical symptom disappearance person is for curing; Menstruation recovery is risen, but menstrual cycle is abnormal, and the clinical symptom relief person is for taking a turn for the better.Continuously menstruation is not seen and is risen after treatment April, or the clinical symptoms no change is invalid.The treatment group is cured 6 examples, 16 examples that take a turn for the better, 8 examples that do not heal, total effective rate 73.3%.Matched group is cured 1 example, and 6 examples take a turn for the better.Total effective rate 46.7%.Treatment group curative effect obviously is better than matched group.
The present invention has the following advantages: the one, and curative effect is reliable; The 2nd, taking convenience safety has no side effect; The 3rd, low price is suitable for vast rural area and uses; The 4th, method for making is easy, and is free from environmental pollution, and suitable society and economic benefit are arranged.
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment:
Radix Polygoni Multiflori (system) 20 restrains by weight ratio, Endoconcha Sepiae 25 grams, Rhizoma Curculiginis 20 grams, Herba Epimedii 20 grams, Cortex Cinnamomi 15 grams.Above-mentioned Chinese medicine of the five flavours is inserted and is added water 300 gram decoctions in the medicine pot to boiling back 20 minutes, and it is standby to take concoction from fire; 2, add 200 gram water on medicinal residues and carry out the 2nd decoction, to boiling back 20 minutes Zhongli's fire, it is standby to take concoction.With the medicine juice of twice decoction through mix, filter, remove slag, drying, insert hard capsule after the sterilization and form.
Claims (3)
1. a medicine for the treatment of premature ovarian failure is characterized in that its primary raw material is made up of following component by weight ratio: Radix Polygoni Multiflori (system) 20%, Endoconcha Sepiae 25%, Rhizoma Curculiginis 20%, Herba Epimedii 20%, Cortex Cinnamomi 15%.
2. the medicine of the described treatment premature ovarian failure of claim 1 is characterized in that it is a capsule.
3. the preparation technology of the pharmaceutical preparation described in the claim 1, it is characterized in that this technology is made up of the following step: insert above-mentioned Chinese medicine of the five flavours in the medicine pot earlier, 3 times of water yields that add the five kinds of Chinese medicine gross weight decoct, and to boiling back 20 minutes, it is standby to take concoction from fire; 2 times of water yields that add former five kinds of Chinese medicine gross weight on medicinal residues are carried out the 2nd decoction, and to boiling back 20 minutes Zhongli's fire, it is standby to take concoction.With the medicine juice of twice decoction through mix, filter, remove slag, drying, sterilization is inserted hard capsule and is formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101868632A CN101181441B (en) | 2007-11-22 | 2007-11-22 | Medicament for curing gonad progeria as well as preparation technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101868632A CN101181441B (en) | 2007-11-22 | 2007-11-22 | Medicament for curing gonad progeria as well as preparation technique thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101181441A true CN101181441A (en) | 2008-05-21 |
| CN101181441B CN101181441B (en) | 2011-03-30 |
Family
ID=39446953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101868632A Expired - Fee Related CN101181441B (en) | 2007-11-22 | 2007-11-22 | Medicament for curing gonad progeria as well as preparation technique thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101181441B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850016B (en) * | 2009-03-31 | 2012-02-22 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating premature ovarian failure and preparation method thereof |
| CN104587408A (en) * | 2015-02-05 | 2015-05-06 | 林久全 | New use of Qilin pills |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400086C (en) * | 2005-12-13 | 2008-07-09 | 王忠民 | Medicine for treating low function of ovary |
-
2007
- 2007-11-22 CN CN2007101868632A patent/CN101181441B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850016B (en) * | 2009-03-31 | 2012-02-22 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating premature ovarian failure and preparation method thereof |
| CN104587408A (en) * | 2015-02-05 | 2015-05-06 | 林久全 | New use of Qilin pills |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101181441B (en) | 2011-03-30 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20080521 |
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| C20 | Patent right or utility model deemed to be abandoned or is abandoned | ||
| RR01 | Reinstatement of patent right |
Former decision: deemed to have abandoned the patent right Former decision publication date: 20110119 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110330 Termination date: 20131122 |