CN105748666A - Pharmaceutical composition containing argy wormwood leaf for preventing and treating depression and climacteric syndrome - Google Patents
Pharmaceutical composition containing argy wormwood leaf for preventing and treating depression and climacteric syndrome Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to the field of traditional Chinese medicines, and relates to a pharmaceutical composition containing argy wormwood leaf for preventing and treating depression and climacteric syndrome. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 16-23 parts of argy wormwood leaf, 15-21 parts of largehead atractylodes rhizome, 14-21 parts of lotus seed, 13-18 parts of immature bitter orange, 10-16 parts of platycladi seed, 13-18 parts of vaccinium bracteatum thumb, 11-16 parts of myrrh, 10-15 parts of glossy privet fruit, 9-14 parts of codonopsis pilosula, 8-13 parts of nutmeg, 8-12 parts of Chinese angelica and 7-11 parts of licorice root. The pharmaceutical composition provided by the invention has the effects of enriching yin and nourishing kidney, reinforcing qi and nourishing blood, promoting blood circulation to restore menstrual flow, invigorating spleen to remove dampness, and soothing nerves to regulate qi, can significantly improve serum estradiol of a castrated rat and reduce the content of follicle-stimulating hormone of the rat, has a significant improvement effect on female hormone of the castrated rat, and is beneficial for treating depression and climacteric syndrome.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to a kind of pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon.
Background technology
Depression refers to a big class mental handicape, commonly referred to collectively as " emotional handicap ".This is a kind of with the low syndrome as principal character of mental state.
This obstacle may slight the best to serious depression from mood, it is different from the most depressed.Emotional handicap includes many different obstacles,
Mainly have: PD and chronic depression.
Climacteric metancholia is the series of symptoms caused by decrease in estrogen.Along with change in menstrual cycle, decrease in estrogen, interior
Excretory system and neural blood vessel function are the most unstable, are temporarily in disorderly period.Thus can cause series of symptoms such as dysphoria, insomnia and dreamful sleep,
Dizziness and tinnitus, dysphoria in chestpalms-soles, warm sweating, edema loose stool, or palpitaition nervous, soreness of the loins and bones, even abnormal feeling etc., it is referred to as climacteric comprehensive
Close disease.Due to the generation of these symptoms, so usually causing depression in patients Menopause when, the most sometimes people are comprehensive climacteric
Disease is referred to as climacteric depression.
" Plain Questions innocence in ancient times opinion " is said: " woman seven years old, kidney qi Sheng, dental transition is sent out long；Two or seven and the menarche, conception vessel lead to, taichong channel contain, menses
With at present, therefore having son ... seventy-seven conception vessels are empty, taichong channel declines few, the menopause, menostasia, thus shape is bad and s.m.p also." this is that women grows and declines
The old natural law, if these changes can be accepted, responds actively, strengthens autoprotection psychologically, mostly can spend climacteric smoothly.Zhou Mintong
Cross and climacteric women quality of life investigated, find climacteric women often oneself aging, sexual deterioration etc. are caused melancholy, anxiety and
The negative thought such as dysphoria, it is therefore necessary to they are strengthened mental hygiene and instructs so that it is understand and grasp involutional physilogical characteristics and change rule
Rule, actively, calmly in the face of everything.
The traditional Chinese medical science thinks that suffering from a deficiency of the kidney is the principle pathological mechanism of menopause, climacteric metancholia, is therefore divided into liver energy stagnation type, renal deficiency type, liver by climacteric metancholia
Strongly fragrant renal deficiency type, liver depression are suffered from a deficiency of the kidney and are held stasis of blood type under the arm.
The kidney being the origin of congenital constitution, and kidney is by wantonly two vascular reason menstruation and the reproductions of punching.Before and after menopause, kidney qi degradation, menses gradually exhausts, and rushes wantonly two feeble pulses and declines, menstruation
To break and the menopause that arrives, fecundity reduces and arrives and disappear.In each stage that women grows, the prosperity and decline of kidney qi is key factor, kidney qi fill Sheng with gradually
Decline be menstrual onset with through the disconnected immanent cause not come, kidney qi decline cause all dirty or even whole body dysfunction be menopausal syndrome fall ill the most former
Cause.Village paramenia to be shown as or even menopause and the shape badly big feature of s.m.p two for women.
Liver function and women's climacteric syndrome have substantial connection, due to liver controlling conveyance and dispersion, store blood, if losing in catharsis, cause feelings will freely feelings easily do not occur
Thread problem such as irritable, anxiety such as suspect at the menopause symptom, if the unbalance visceral dysfunction of qi and blood, cause disease occur or increase the weight of.Climacteric women
Experience produces the physiology course of fertility, simultaneously because it is strongly fragrant to cause seven feelings to stroke from the pressure of more live and work, if liver is lost, bar reaches, catharsis is immoderate,
Functional activity of QI being not smooth, blood cause all diseases with the stagnation of the circulation of vital energy, disharmony of Chong and Conception Channels.
Additionally through the morbidity close relation deeply grinding in high discovery burnt taste and climacteric metancholia of traditional Chinese medical science scholar, as warmed sweating, insomnia
The burning hot symptom such as dreaminess, irritable with weakness of the spleen and the stomach, to rise clear deficiency, yin fire upper punch relevant.
Chinese patent application CN201410621748 discloses a kind of Chinese medicine composition treating climacteric metancholia, and this Chinese medicine composition is by following heavy
The raw material of amount part is prepared from: red sage root 10-15, Radix Codonopsis 10-15, asparagus fern 5-10, fruit of glossy privet 15-20, Eclipta prostrata 10-15, lily 15-20, Huang
Even 5-10, light wheat 10-15, jujube kernel 10-15, root tuber of aromatic turmeric 15-20, keel 15-20, fruit of Chinese magnoliavine 10-15, Poria cocos 10-15, root of herbaceous peony 5-10, when
Return 10-15 and Rhizoma Sparganii 10-15, this Chinese medicine composition have nourishing heart, calm the nerves, flat liver, clear away heart-fire, kidney tonifying, nourshing kidney, qi-supplementing, blood-engendering, soft liver, work
Effect of blood, but this pharmaceutical compositions is complicated, and medicine cost is of a relatively high.
Summary of the invention
It is an object of the invention to overcome weak point of the prior art, it is provided that a kind of pharmaceutical composition preventing and treating depression and climacteric metancholia, tool
Body relates to a kind of pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon.This pharmaceutical composition have enriching yin and nourishing kidney, nourishing qi and blood,
Promoting blood circulation for regulating menstruation, invigorating the spleen dry, effect regulated the flow of vital energy of calming the nerves, and also have good effect, have no side effect and the advantage such as taking convenience.Additionally, the present invention is also
There is provided corresponding manufacture method to be made on the premise of ensureing curative effect by this pharmaceutical composition and facilitate easy-to-use preparation.
Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:
Tarragon 16-23 part, bighead atractylodes rhizome 15-21 part, lotus seeds 14-21 part, dried immature fruit of citron orange 13-18 part, seed of Oriental arborvitae 10-16 part, fragile blueberry fruit 13-18 part, do not have
Medicine 11-16 part, fruit of glossy privet 10-15 part, Radix Codonopsis 9-14 part, nutmeg 8-13 part, Radix Angelicae Sinensis 8-12 part and Radix Glycyrrhizae 7-11 part.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Tarragon 16 parts, the bighead atractylodes rhizome 15 parts, 14 parts of lotus seeds, the dried immature fruit of citron orange 13 parts, the seed of Oriental arborvitae 10 parts, fragile blueberry fruit 13 parts, myrrh 11 parts, the fruit of glossy privet
10 parts, Radix Codonopsis 9 parts, nutmeg 8 parts, Radix Angelicae Sinensis 8 parts and 7 parts of Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Tarragon 23 parts, the bighead atractylodes rhizome 21 parts, 21 parts of lotus seeds, the dried immature fruit of citron orange 18 parts, the seed of Oriental arborvitae 16 parts, fragile blueberry fruit 18 parts, myrrh 16 parts, the fruit of glossy privet
15 parts, Radix Codonopsis 14 parts, nutmeg 13 parts, Radix Angelicae Sinensis 12 parts and 11 parts of Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Tarragon 21 parts, the bighead atractylodes rhizome 18 parts, 17 parts of lotus seeds, the dried immature fruit of citron orange 16 parts, the seed of Oriental arborvitae 13 parts, fragile blueberry fruit 15 parts, myrrh 13 parts, the fruit of glossy privet
12 parts, Radix Codonopsis 11 parts, nutmeg 11 parts, Radix Angelicae Sinensis 10 parts and 9 parts of Radix Glycyrrhizae.
Correspondingly, the preparation method of described pharmaceutical composition comprises following step:
S1: weigh tarragon, the bighead atractylodes rhizome, lotus seeds, the dried immature fruit of citron orange, the seed of Oriental arborvitae, fragile blueberry fruit, myrrh, the fruit of glossy privet, Radix Codonopsis, nutmeg, Radix Angelicae Sinensis and Radix Glycyrrhizae each
Taste medicinal material, pulverizes respectively, standby；
S2: the medicinal material coarse powder prepared by S1 merges, and adds the purified water of initial 8-12 times of weight of medicinal material, soaks 12-24 hour, decocts 1-3 little
Time, filter；Add the purified water of medicinal material gross weight 5-9 times weight, decoct 1-3 hour, filter and retain filter residue, merging filtrate, be concentrated into
55-60 DEG C of relative density is that the concentrate of 1.20-1.25 is standby；
S3: add the ethanol of concentration 65-80% of medicinal material gross weight 5-7 times weight toward the filter residue of S2, refluxing extraction 2-3 time, each 2-5 hour,
Filtering, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrate that 55-60 DEG C of relative density is 1.20-1.25；
S4: the concentrate of S2, S3 gained is merged, continues to be concentrated into the Chinese medical concrete that 55-60 DEG C of relative density is 1.33-1.38, i.e. get Ben Fa
Bright pharmaceutical composition.
Further, described pharmaceutical composition is made into capsule, tablet, powder, oral liquid, granule or pill.
The source of component used by the present invention, nature and flavor, return through and effect:
Tarragon: for the dry leaf of feverfew Chinese mugwort；Taste is pungent, bitter, warm in nature, returns liver,spleen,kidney warp；Warming channel for arresting bleeding, eliminating cold to stop pain, menstruation regulating is pacified
Tire, removing dampness to relieve itching, clearing and activating the channels and collaterals.
The bighead atractylodes rhizome: for the dry rhizome of the feverfew bighead atractylodes rhizome；Bitter, sweet, warm in nature；Return spleen, stomach warp；Strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, peace
Tire.
Lotus seeds: for the dry mature seed of nymphaeaceae plant lotus；Taste is sweet, puckery, and property is put down；Return spleen, kidney, the heart channel of Hang-Shaoyin；Tonifying spleen and stopping diarrhea, the puckery essence of kidney-nourishing,
Mental-tranquilization.
The dried immature fruit of citron orange: for rutaceae bitter orange and variety thereof or the dry young fruit of sweet orange；Bitter, pungent, sour, warm in nature；Return spleen, stomach warp；Relieving stagnant Qi
Disappear long-pending, scattered ruffian of reducing phlegm.
The seed of Oriental arborvitae: for the dry mature kernal of Cupressaceae plant arbor-vitae；Taste is sweet, and property is put down；The thoughts of returning home, kidney, large intestine channel；Mental-tranquilization, hidroschesis, ease constipation.
Fragile blueberry fruit: for the fruit of ericad crow fruit；Taste is sweet, sour, warm in nature；Calm the nerves, cough-relieving.
Myrrh: for Burseraceae bdellium plant myrrh and belong to him together and plant the oleo-gum-resin that the trunk skin zone of plant oozes out；Bitter, property is put down；Return Liver Channel；
Scattered blood removes the stasis of blood, detumescence ding-tong.
The fruit of glossy privet: for the fruit of Oleaceae Ligustrum plant glossy privet；Taste is sweet, bitter, cool in nature；Return liver, kidney channel；Tonify the liver and kidney, improving eyesight, clearind deficient heat.
Radix Codonopsis: for Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or the dry root of radix codonpsis tangshen；Taste is sweet, and property is put down；Return spleen, lung channel；Tonifying middle-Jiao and Qi, invigorating the spleen
Benefit lung.
Nutmeg: for the myristic dry kind of benevolence of Myristicaceae Myristica plant；Taste is pungent, warm in nature；Return spleen, stomach, large intestine channel；Promoting the circulation of qi in temperature,
Relieving diarrhea with astringents.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica；Its taste is sweet, pungent, warm in nature；Return liver, the heart, the spleen channel；Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, profit
Intestines defaecation.
Radix Glycyrrhizae: for glycyrrhizic legume, swollen fruit Radix Glycyrrhizae or the dry root of glycyrrhiza glabra.Taste is sweet, and property is put down；The thoughts of returning home, lung, spleen, stomach warp；Tonifying spleen benefit
Gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
The prescription analysis of Chinese medicine of the present invention:
According to the compatibility theory of the traditional Chinese medical science dialectical and Chinese medicine to having depression and climacteric metancholia, in conjunction with fitness and the modern system of modern
The feature of medicine technology, the collocation ingredients of reasonable science, form Chinese prescription of the present invention.The prescription of the present invention is with tarragon and the bighead atractylodes rhizome as monarch drug in a prescription,
Warming channel for arresting bleeding, eliminating cold to stop pain, strengthening the spleen and replenishing qi, clearing and activating the channels and collaterals；With lotus seeds, the dried immature fruit of citron orange and the seed of Oriental arborvitae as ministerial drug, reinforcing spleen and kidney, mental-tranquilization, relieving stagnant Qi
Disappear long-pending；With fragile blueberry fruit, myrrh, the fruit of glossy privet, Radix Codonopsis and nutmeg as adjutant, calming the nerves, scattered blood goes the stasis of blood, tonifies the liver and kidney, promoting the circulation of qi in temperature, invigorating the spleen benefit
Lung；With Radix Angelicae Sinensis and Radix Glycyrrhizae for making medicine, inrigorating qi and promoting blood circulation, enriching yin of enriching blood, coordinating the drug actions of a prescription；The all medicines of monarch coordinate, collaborative promotion, complement each other,
Be finally reached enriching yin and nourishing kidney, nourishing qi and blood, promoting blood circulation for regulating menstruation, invigorating the spleen are dried, effect regulated the flow of vital energy of calming the nerves, and are suitable for the trouble of depression and climacteric metancholia
Person.
Compared with prior art, the present invention has a following technical advantage:
1, results of animal shows, pharmaceutical composition of the present invention can significantly increase Ovariectomized Rat Serum estradiol and its follicle-stimulating hormone of reduction contains
Amount, it is seen then that medicine of the present invention is significantly improved effect to castrated rats estrogen, is conducive to treatment depression and climacteric metancholia；
2, compared with the chemotherapeutic agent of Current therapeutic depression and climacteric metancholia, the prescription of pharmaceutical composition of the present invention is the medicine of pure natural
Material, bad reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, and medication effect more preferably, efficiently solves depression
The morbidity root of disease and climacteric metancholia, and improve the quality of life of patient；
3, pharmaceutical composition of the present invention also has compatibility science, cure rate is high, be difficult to the advantages such as recurrence.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following example represents the performance in the practice of the invention that the inventors discovered that good
The technology of effect.But, disclosed specific embodiments can be made many changes, and still obtain same or analogous result, and not
Depart from the spirit and scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: tarragon 16 parts, the bighead atractylodes rhizome 15 parts, 14 parts of lotus seeds,
The dried immature fruit of citron orange 13 parts, the seed of Oriental arborvitae 10 parts, fragile blueberry fruit 13 parts, myrrh 11 parts, the fruit of glossy privet 10 parts, Radix Codonopsis 9 parts, nutmeg 8 parts, Radix Angelicae Sinensis 8 parts
With 7 parts of Radix Glycyrrhizae.
Preparation method is as follows:
S1: weigh respectively by Chinese prescription tarragon, the bighead atractylodes rhizome, lotus seeds, the dried immature fruit of citron orange, the seed of Oriental arborvitae, fragile blueberry fruit, myrrh, the fruit of glossy privet, Radix Codonopsis, nutmeg,
Radix Angelicae Sinensis and Radix Glycyrrhizae ingredients, pulverize respectively, standby；
S2: the medicinal material coarse powder prepared by S1 merges, and adds the purified water of initial 10 times of weight of medicinal material, soaks 18 hours, decocts 2 hours, mistake
Filter, adds the purified water of 6 times of weight of initial weight, decocts 2 hours, filter and retain filter residue, merging filtrate, be concentrated into 60 DEG C of relative densities
Be 1.20 concentrate standby；
S3: the filter residue toward S2 adds the ethanol of the concentration 75% of 6 times of weight, refluxing extraction 2 times, each 2 hours, filters, merging filtrate, subtracts
Pressure is distilled off ethanol, and it is standby to be concentrated into the concentrate that 60 DEG C of relative densities are 1.20；
S4: being merged by the concentrate of S2, S3 gained, continuing to be concentrated into 60 DEG C of relative densities is the Chinese medical concrete of 1.33, obtains medicine group of the present invention
Compound medicinal extract；
S5: the Chinese medical concrete of S4 is added capsule and commonly uses auxiliary material, mixing, step-down dry, pulverize, and crosses 100 mesh sieves, loads in capsule shells,
Every capsule medicated amount is 0.4g, obtains the capsule of the embodiment of the present invention 1 pharmaceutical composition.
Embodiment 2
The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: tarragon 23 parts, the bighead atractylodes rhizome 21 parts, 21 parts of lotus seeds,
The dried immature fruit of citron orange 18 parts, the seed of Oriental arborvitae 16 parts, fragile blueberry fruit 18 parts, myrrh 16 parts, the fruit of glossy privet 15 parts, Radix Codonopsis 14 parts, nutmeg 13 parts, Radix Angelicae Sinensis 12
Part and 11 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: tarragon 20 parts, the bighead atractylodes rhizome 17 parts, 16 parts of lotus seeds,
The dried immature fruit of citron orange 15 parts, the seed of Oriental arborvitae 12 parts, fragile blueberry fruit 14 parts, myrrh 12 parts, the fruit of glossy privet 11 parts, Radix Codonopsis 10 parts, nutmeg 10 parts, Radix Angelicae Sinensis 9
Part and 8 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4
The embodiment of the present invention 4 pharmaceutical composition is prepared from by the raw material of following parts by weight: tarragon 22 parts, the bighead atractylodes rhizome 19 parts, 18 parts of lotus seeds,
The dried immature fruit of citron orange 17 parts, the seed of Oriental arborvitae 14 parts, fragile blueberry fruit 16 parts, myrrh 14 parts, the fruit of glossy privet 13 parts, Radix Codonopsis 12 parts, nutmeg 12 parts, Radix Angelicae Sinensis 11
Part and 10 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 5
The embodiment of the present invention 5 pharmaceutical composition is prepared from by the raw material of following parts by weight: tarragon 21 parts, the bighead atractylodes rhizome 18 parts, 17 parts of lotus seeds,
The dried immature fruit of citron orange 16 parts, the seed of Oriental arborvitae 13 parts, fragile blueberry fruit 15 parts, myrrh 13 parts, the fruit of glossy privet 12 parts, Radix Codonopsis 11 parts, nutmeg 11 parts, Radix Angelicae Sinensis 10
Part and 9 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Test example one, the pharmaceutical composition of the present invention impact on castrated rats hormonal readiness
1. animal used as test: SPF level female sd inbred rats 80, body weight 225 ± 9g, is provided by Guangdong Province's Experimental Animal Center.
2. Experimental agents: the capsule that embodiment of the present invention 1-5 prepares respectively；Positive control drug is that (new sky, Kweiyang medicine company share has Kuntai capsule
Limit company, traditional Chinese medicines quasi-word Z20000083,0.5g*24 grain/box).
3. prepared by model: after female rats being anaesthetized, under most end rib, and midaxillary line and about 2cm infall outside backbone deduct and become mildewed, cut
Open skin and dorsal muscles about 1.5～2cm, related for fallopian tubal under ovary fat silk thread is ligatured, extract ovary.After performing the operation 5 days, animal is carried out the moon
Road cast-off cells plate coating checking, once a day, continuous 5 days, basis of microscopic observation cell picture occurred without oestrous cycle reaction and proves modeling success.
4. experimental technique:
80 rats are randomly divided into 8 groups, often group 10, are respectively as follows: blank group, test A-E group, positive controls, model group,
In addition to blank group, remaining each group carries out modeling, carries out gastric infusion after modeling success, and wherein test A-E group gavage respectively is real to the present invention
Executing the solution of the capsule preparation that example 1-5 prepares, dosage is 40mg/kg；Positive controls gavage gives the solution of commercially available Kuntai capsule preparation,
Dosage is 25mg/kg；Blank group and the equal gavage of model group, to the physiological saline of equivalent, respectively organize gavage every day 1 time, continuous gavage 1
Put to death rat after Yue, detect the hormone-content in each group of rat body.
5. experimental result
The comparision contents of hormone in rat blood serum respectively organized by table 1
| Group | Quantity | Dosage mg/kg | Follicle-stimulating hormone (ng/ml) | Estradiol (pg/ml) |
| Blank group | 10 | - | 2.82±0.32 | 58.12±3.89 |
| Model group | 10 | - | 5.63±0.89ΔΔ | 29.69±2.17△△ |
| Positive controls | 10 | 25 | 3.77±0.52* | 52.20±3.14** |
| A group | 10 | 40 | 3.68±0.68* | 45.59±3.87* |
| B group | 10 | 40 | 3.72±0.53* | 44.92±3.54* |
| C group | 10 | 40 | 3.79±0.45* | 41.65±3.22* |
| D group | 10 | 40 | 3.80±0.42* | 40.95±2.63* |
| E group | 10 | 40 | 3.56±0.50* | 51.82±2.55** |
Note: compare with blank group,ΔΔP ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01.
From upper table data, comparing with Normal group, the serum estradiol content of model group rats significantly reduces, and follicle-stimulating hormone content significantly rises
Height, illustrates this experimental animal model modeling success.Give pharmaceutical composition of the present invention to treat, it is possible to be obviously improved modeling rat blood serum estradiol
Content, significantly reduce the content of follicle-stimulating hormone simultaneously, illustrate that medicine of the present invention is significantly improved effect to castrated rats estrogen, its effect with
The result for the treatment of of positive controls is suitable, and with the embodiment 5 prepared pharmaceutical composition improvement result best results to castrated rats estrogen.
Test example two, the pharmaceutical composition of the present invention observation of curative effect to female dimacteric syndrome clinical volunteers patient
One, diagnostic criteria
With reference to the diagnostic criteria of climacteric metancholia in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":
1, mostly occur more than 45 years old, irregular menses or amenorrhoea, hectic fever, perspiration, palpitaition, emotional, insomnia or the symptom such as depressed；
2, reproductive organs and secondary sex characters have atrophy in various degree；
3, urine, blood estrogen reduce, and follicle-stimulating hormone and lutropin are significantly raised.
Two, criterion of therapeutical effect
With reference to the efficacy assessment standard of climacteric metancholia in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":
Cure: warm, sweating, agitation, the transference cure such as depression, feel comfortable；
Effective: warm, sweating, agitation, the symptom such as depression alleviate；
Invalid: after taking medicine, the state of an illness is unchanged.
Three, clinical testing
1, physical data
The female dimacteric syndrome clinical volunteers patient that 480 are selected is divided into 4 groups at random, often organizes 120 people, respectively test A, B,
C group and control group, respectively organize the influence factors such as the age of patient, symptom, and through statistical procedures, there was no significant difference, meets packet condition.
2, methods for the treatment of
Test A, B, C group: take the capsule (0.4g*60 grain/bottle) that the embodiment of the present invention 1,2,5 prepares respectively, every day 2 times, often
Secondary 4, it serve on one month；
Control group: take Kuntai capsule (Guiyang Xintian Pharmaceutical Industry Co., Ltd., traditional Chinese medicines quasi-word Z20000083,0.5g*24 grain/box), one time 4
Grain, 3 times on the one, serve on three months.
3, treatment results, as shown in table 2.
The result for the treatment of of clinical volunteer patients respectively organized by table 2
| Group | Number of cases | Cure (rate) | Effectively | Invalid | Total effective rate |
| Test A group | 120 | 93 (77.5%) | 19 | 8 | 93.3% |
| Test B group | 120 | 94 (78.3%) | 16 | 10 | 91.7% |
| Test C group | 120 | 100 (83.3%) | 14 | 6 | 95.0% |
| Control group | 120 | 97 (80.8%) | 16 | 7 | 94.2% |
This test uses Kuntai capsule as a control group, and Kuntai capsule is carried meticulously by Chinese medicines such as prepared rhizome of rehmannia, the coptis, the root of herbaceous peony, the root of large-flowered skullcap, donkey-hide gelatin, Poria cocos
Refining forms, and has nourishing Yin and clearing heat, to calm the nerves relieving restlessness effect, can be clinically used for depression and climacteric metancholia.Knowable to upper table data, this
The cure rate of the capsule that bright embodiment 1,2,5 prepares respectively reaches more than 75%, and total effective rate reaches more than 90%, and the treatment with positive control drug is imitated
Fruit is suitable, and the result for the treatment of with test C group is optimal.Result above proves medicine composite for curing depression of the present invention and climacteric metancholia effect
Fruit is notable, has enriching yin and nourishing kidney, nourishing qi and blood, promoting blood circulation for regulating menstruation, invigorating the spleen are dried, effect regulated the flow of vital energy of calming the nerves, can as clinical treatment depression and more
Term syndrome medicament uses, and clinical generalization value is high.
Owing to describing the present invention by above preferred embodiment, in the spirit and/or scope of the present invention, any replacement for the present invention/
Or combination implement the present invention, will be apparent from for a person skilled in the art, and be included among the present invention.
Claims (6)
1. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon, it is characterised in that described pharmaceutical composition is by following weight
The raw material of number is prepared from:
Tarragon 16-23 part, bighead atractylodes rhizome 15-21 part, lotus seeds 14-21 part, dried immature fruit of citron orange 13-18 part, seed of Oriental arborvitae 10-16 part, fragile blueberry fruit 13-18 part, do not have
Medicine 11-16 part, fruit of glossy privet 10-15 part, Radix Codonopsis 9-14 part, nutmeg 8-13 part, Radix Angelicae Sinensis 8-12 part and Radix Glycyrrhizae 7-11 part.
2. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon as claimed in claim 1, it is characterised in that described medicine group
Compound is prepared from by the raw material of following parts by weight:
Tarragon 16 parts, the bighead atractylodes rhizome 15 parts, 14 parts of lotus seeds, the dried immature fruit of citron orange 13 parts, the seed of Oriental arborvitae 10 parts, fragile blueberry fruit 13 parts, myrrh 11 parts, the fruit of glossy privet
10 parts, Radix Codonopsis 9 parts, nutmeg 8 parts, Radix Angelicae Sinensis 8 parts and 7 parts of Radix Glycyrrhizae.
3. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon as claimed in claim 1, it is characterised in that described medicine group
Compound is prepared from by the raw material of following parts by weight:
Tarragon 23 parts, the bighead atractylodes rhizome 21 parts, 21 parts of lotus seeds, the dried immature fruit of citron orange 18 parts, the seed of Oriental arborvitae 16 parts, fragile blueberry fruit 18 parts, myrrh 16 parts, the fruit of glossy privet
15 parts, Radix Codonopsis 14 parts, nutmeg 13 parts, Radix Angelicae Sinensis 12 parts and 11 parts of Radix Glycyrrhizae.
4. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon as claimed in claim 1, it is characterised in that described medicine group
Compound is prepared from by the raw material of following parts by weight:
Tarragon 21 parts, the bighead atractylodes rhizome 18 parts, 17 parts of lotus seeds, the dried immature fruit of citron orange 16 parts, the seed of Oriental arborvitae 13 parts, fragile blueberry fruit 15 parts, myrrh 13 parts, the fruit of glossy privet
12 parts, Radix Codonopsis 11 parts, nutmeg 11 parts, Radix Angelicae Sinensis 10 parts and 9 parts of Radix Glycyrrhizae.
5. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon as described in claim 1-4 is arbitrary, it is characterised in that described
Pharmaceutical composition is made into capsule, tablet, powder, oral liquid, granule or pill.
6. the pharmaceutical composition preventing and treating depression and climacteric metancholia containing tarragon as described in claim 1-4 is arbitrary, it is characterised in that described
The preparation method of pharmaceutical composition comprises following step:
S1: weigh tarragon, the bighead atractylodes rhizome, lotus seeds, the dried immature fruit of citron orange, the seed of Oriental arborvitae, fragile blueberry fruit, myrrh, the fruit of glossy privet, Radix Codonopsis, nutmeg, Radix Angelicae Sinensis and Radix Glycyrrhizae each
Taste medicinal material, pulverizes respectively, standby；
S2: the medicinal material coarse powder prepared by S1 merges, and adds the purified water of initial 8-12 times of weight of medicinal material, soaks 12-24 hour, decocts 1-3 little
Time, filter；Add the purified water of medicinal material gross weight 5-9 times weight, decoct 1-3 hour, filter and retain filter residue, merging filtrate, be concentrated into
55-60 DEG C of relative density is that the concentrate of 1.20-1.25 is standby；
S3: add the ethanol of concentration 65-80% of medicinal material gross weight 5-7 times weight toward the filter residue of S2, refluxing extraction 2-3 time, each 2-5 hour,
Filtering, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrate that 55-60 DEG C of relative density is 1.20-1.25；
S4: the concentrate of S2, S3 gained is merged, continues to be concentrated into the Chinese medical concrete that 55-60 DEG C of relative density is 1.33-1.38, i.e. get Ben Fa
Bright pharmaceutical composition.
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| CN201610206717.0A CN105748666A (en) | 2016-04-01 | 2016-04-01 | Pharmaceutical composition containing argy wormwood leaf for preventing and treating depression and climacteric syndrome |
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| CN201610206717.0A CN105748666A (en) | 2016-04-01 | 2016-04-01 | Pharmaceutical composition containing argy wormwood leaf for preventing and treating depression and climacteric syndrome |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106890085A (en) * | 2017-01-23 | 2017-06-27 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion climacteric metancholia |
| EP3549455A4 (en) * | 2016-12-01 | 2019-10-09 | Jeonnam Bioindustry Foundation | Health functional food composition for preventing and alleviating depression, containingvaccinium bracteatum |
| US11944661B2 (en) * | 2017-06-01 | 2024-04-02 | Jeonnam Bioindustry Foundation | Pharmaceutical composition containing extract of leaves of Vaccinium bracteatum Thunb. for prevention or treatment of stress disease and depression |
-
2016
- 2016-04-01 CN CN201610206717.0A patent/CN105748666A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3549455A4 (en) * | 2016-12-01 | 2019-10-09 | Jeonnam Bioindustry Foundation | Health functional food composition for preventing and alleviating depression, containingvaccinium bracteatum |
| JP2019536798A (en) * | 2016-12-01 | 2019-12-19 | ジョンナム バイオインダストリー ファウンデーション | A health-functional food composition for preventing and ameliorating depression, comprising an extract of shashanbo seeds |
| US10925914B2 (en) | 2016-12-01 | 2021-02-23 | Jeonnam Bioindustry Foundation | Method for alleviating depression using a health functional food containing Vaccinium bracteatum Thunb fruit extract |
| JP2021151245A (en) * | 2016-12-01 | 2021-09-30 | ジョンナム バイオインダストリー ファウンデーション | Health functional food composition for preventing and improving melancholia containing extract of vaccinium bracteatum thunb. fruit |
| JP7189137B2 (en) | 2016-12-01 | 2022-12-13 | ジョンナム バイオインダストリー ファウンデーション | Health functional food composition for preventing and ameliorating depression containing extract of Citrus fruit |
| CN106890085A (en) * | 2017-01-23 | 2017-06-27 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion climacteric metancholia |
| US11944661B2 (en) * | 2017-06-01 | 2024-04-02 | Jeonnam Bioindustry Foundation | Pharmaceutical composition containing extract of leaves of Vaccinium bracteatum Thunb. for prevention or treatment of stress disease and depression |
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Application publication date: 20160713 |