CN114699474A

CN114699474A - Traditional Chinese medicine composition for treating ovarian reserve function reduction and application thereof

Info

Publication number: CN114699474A
Application number: CN202111598227.7A
Authority: CN
Inventors: 陈雪琴; 宋佳怡; 沈宏平; 冯定军
Original assignee: Ningbo First Hospital
Current assignee: Ningbo First Hospital
Priority date: 2021-12-24
Filing date: 2021-12-24
Publication date: 2022-07-05

Abstract

The invention provides a traditional Chinese medicine composition for treating ovarian reserve function reduction and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines: radix rehmanniae Preparata, parched Atractylodis rhizoma, rhizoma Dioscoreae, radix Angelicae sinensis, parched radix Paeoniae alba, parched semen Ziziphi Spinosae, cortex moutan, bupleuri radix, radix Dipsaci, radix Codonopsis, radix Glehniae, semen Cuscutae, fructus Ligustri Lucidi, and pericarpium Citri Tangerinae. The traditional Chinese medicine composition is supported by the traditional Chinese medicine classic theory, has reasonable formula and proper compatibility, can tonify kidney and replenish essence, warm yang and tonify qi, nourish blood and nourish liver, thereby improving the ovarian function and clinical symptoms, and has definite curative effect, obvious effect, no obvious adverse reaction and good safety.

Description

Traditional Chinese medicine composition for treating ovarian reserve function reduction and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ovarian reserve function reduction and application thereof.

Background

Decreased Ovarian Reserve (DOR) refers to decreased oocyte number and quality in women, which can lead to decreased fertility potential in women of fertile age. The american national assisted reproduction technical association reports that ovarian reserve function is the second leading cause of assisted pregnancy in patients who choose assisted reproduction, accounting for 32% of in vitro fertilization-embryo transfer (IVF-ET) patients, but with a minimum live yield of only 13.1%. In China, the infertility rate of couples of childbearing age is increased from 3% to 15% before 20 years, the infertility caused by DOR accounts for about 10%, and the number of infertility caused by the reduction of ovarian reserve function is in a rising state. Moreover, when premature ovarian failure occurs in more and more young women, if effective intervention is not performed in time, the women may have ovarian atrophy within 1 to 6 years, progress to premature ovarian failure, and even lose fertility. The reduction of the ovarian reserve function is accompanied with the reduction of the quality of the oocyte, and the pregnancy rate is reduced, and the abortion rate and the embryo teratogenesis rate are increased, so that the problem and the challenge of the reproductive medicine are that how to reduce the ovarian reserve function of the female in the 'upper pregnant part' and the 'lower born part' are great problems and challenges. Besides infertility, long-term deficiency of ovarian hormone can lead to occurrence of multiple systemic diseases such as nerve, cardiovascular, urinary system, skin and bone system, etc., perimenopausal symptoms appear, and life quality of patients is affected.

In order to improve the ovarian function of patients, experts at home and abroad try different treatment modes, hormone replacement therapy is mostly adopted in the existing treatment for DOR patients with no fertility requirement, the therapy can relieve the low estrogen symptoms of the patients but can not radically improve the ovarian function, the recurrence rate is high after the drug withdrawal, and the therapy can not be used for patients with certain hormone-dependent diseases; for DOR patients with fertility requirements, coenzyme Q10 and dehydroepiandrosterone are commonly used in an auxiliary mode, growth hormone is added in the auxiliary reproductive ovary stimulation process, and the like, but the treatment is mainly limited to increase the number of obtained eggs, and the quality of the reduced oocytes is not improved, so that research shows that the treatment can improve the ovarian function of the patients to a certain extent, but has no influence on the survival rate.

The infertility treated by the traditional Chinese medicine has a long history, the advantages in the aspect of ovarian function improvement are increasingly highlighted, the traditional Chinese medicine considers that the root cause of the DOR is kidney essence deficiency, and a treatment method for tonifying kidney and replenishing essence is adopted. The traditional Chinese medicine can play effects in multiple ways and multiple target points, improve the environment in the organism, stimulate the organism to repair the self functions, improve the ovarian function of a patient and simultaneously improve clinical symptoms, and has lasting curative effect and less side effects. For example, CN107441313A discloses a Chinese medicinal composition for treating diminished ovarian reserve function, which is prepared from 10-20 parts of raspberry, 10-20 parts of dodder, 10-20 parts of cistanche, 15-30 parts of kudzu root, 10-15 parts of asparagus, 10-15 parts of angelica, 10-15 parts of fried white peony root and 10-15 parts of platycladi seed, and can treat symptoms of hypomenorrhea, infrequent menstruation, amenorrhea and perimenopausal period of patients with diminished ovarian reserve function; CN103520487A discloses a pharmaceutical composition for treating ovarian reserve function decline and/or promoting endometrial development, which is prepared from 15-35 parts of epimedium, 10-20 parts of glossy privet fruit, 5-15 parts of fragrant solomonseal rhizome, 5-15 parts of black soybean, 5-15 parts of sophora flower, 5-15 parts of mulberry, 5-15 parts of raspberry, 1-5 parts of American ginseng, 2-9 parts of donkey-hide gelatin and 1-5 parts of paecilomyces hepiali mycelium powder, and can treat ovarian function decline and improve the symptoms of reproductive organ atrophy and perimenopause of patients.

Although the above patent applications describe that the traditional Chinese medicine prescription has a certain curative effect, in view of the large market demand of the medicines for treating ovarian failure, the constitution of each patient is different, and the problems of uncertain curative effect and unobvious effect of the traditional Chinese medicine prescription exist, the development of a traditional Chinese medicine preparation which has the advantages of definite curative effect, simple and convenient administration, safety and no toxic or side effect is urgently needed, and more medicine choices are provided for clinicians and patients.

Disclosure of Invention

In order to solve the defects of the prior art, the invention aims to provide the traditional Chinese medicine composition which is reasonable in formula and obvious in effect and is used for treating the ovarian reserve function reduction.

The above object of the present invention can be achieved by the following technical solutions:

a traditional Chinese medicine composition for treating ovarian reserve function reduction is prepared from the following raw material medicines in parts by weight: 20-35 parts of prepared rehmannia root, 15-35 parts of fried bighead atractylodes rhizome, 10-30 parts of Chinese yam, 10-20 parts of angelica, 10-20 parts of fried white peony root, 10-30 parts of fried spina date seed, 10-20 parts of moutan bark, 5-20 parts of radix bupleuri, 10-20 parts of teasel root, 10-20 parts of codonopsis pilosula, 10-20 parts of radix glehniae, 10-30 parts of semen cuscutae, 10-30 parts of glossy privet fruit and 5-20 parts of dried orange peel.

Preferably, the traditional Chinese medicine composition for treating ovarian reserve function reduction is prepared from the following raw material medicines in parts by weight: 25-35 parts of prepared rehmannia root, 25-35 parts of fried bighead atractylodes rhizome, 10-20 parts of Chinese yam, 10-15 parts of angelica sinensis, 10-15 parts of fried white peony root, 10-20 parts of fried spina date seed, 10-15 parts of moutan bark, 5-10 parts of radix bupleuri, 15-20 parts of teasel root, 10-15 parts of codonopsis pilosula, 10-20 parts of radix glehniae, 15-20 parts of semen cuscutae, 15-20 parts of glossy privet fruit and 5-10 parts of dried orange peel.

Preferably, the traditional Chinese medicine composition for treating ovarian reserve function reduction is prepared from the following raw material medicines in parts by weight: 30 parts of prepared rehmannia root, 30 parts of fried bighead atractylodes rhizome, 15 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 10 parts of fried spina date seed, 10 parts of tree peony bark, 6 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 12 parts of codonopsis pilosula, 15 parts of coastal glehnia root, 15 parts of south dodder seed, 15 parts of glossy privet fruit and 9 parts of tangerine peel.

Preferably, the traditional Chinese medicine composition for treating the ovarian reserve function reduction comprises a medically acceptable medicine carrier.

The invention also aims to disclose the application of the traditional Chinese medicine composition in preparing a medicine for treating ovarian reserve function reduction.

Preferably, the dosage form of the medicine is granule, oral liquid, tablet, capsule, powder, pill or paste.

The invention has the following beneficial effects:

the traditional Chinese medicine composition is supported by the traditional Chinese medicine classic theory, has reasonable formula and proper compatibility, can tonify kidney and replenish essence, warm yang and replenish qi, nourish blood and nourish liver, thereby improving the ovarian function and clinical symptoms, and has definite curative effect, obvious effect, no obvious adverse reaction and good safety.

The traditional Chinese medicine composition can be used for preparing medicines for treating ovarian reserve function reduction, can be selected from various dosage forms, and has the advantages of convenience in treatment, long drug effect, portability of the medicines, stable curative effect, strong medicine economy and the like while ensuring the curative effect.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention relates to a traditional Chinese medicine composition for treating ovarian reserve function reduction, which is prepared from the following raw material medicines: radix rehmanniae Preparata, parched Atractylodis rhizoma, rhizoma Dioscoreae, radix Angelicae sinensis, radix Paeoniae alba preparata, semen Ziziphi Spinosae preparata, cortex moutan, bupleuri radix, radix Dipsaci, radix Codonopsis, radix Glehniae, semen Cuscutae, fructus Ligustri Lucidi, and pericarpium Citri Tangerinae.

The hypofunction of ovary reserve is the name of modern medicine, and can be classified into the categories of "advanced menstruation", "scanty menstruation", "amenorrhea", "blood depletion", "infertility", "symptoms before and after menopause" and the like in traditional Chinese medicine. The traditional Chinese medicine considers that the kidney is the congenital foundation and governs reproduction and growth, the sex-stimulating hormone in the kidney is the key factor of female growth and reproduction, and the plain questions and the ancient Tianzhen treatise have cloud, the female is seven years old, the kidney is vigorous, and the teeth are grown more. The second seven, the third one, the fifth one and the sixth one, the ren channel is open, the Taichong pulse is strong, the moon is in the late morning, so there are son … … Qiqi, the ren channel is weak, the Taichong pulse is weak, the Tian Dec is exhausted, the tunnel is obstructed, so there is no son or son. "means" till "and" exhausted "of Tian Dec are closely related to the growth, sturdiness and aging of human body. Ming, Madil, cloud of Huangdi's Cansu wen Ling Shu Zhu Zhen Zheng Fa Wei: "Tianqi is also called Tianqi because yin essence, covering kidney, and decyl also belong to water, which is generated by innate qi accumulation. "Ming, Zhang Jingyue" classics: "Tian Dec is a" Yuan Yin "… … it is in the human body, and" Yuan Yin "it is thought that Tian Dec is a" Yuan Yin ", it is the innate essence and stores in the kidney. Kidney yin can nourish viscera and blood, while kidney essence is abundant, which leads to vigorous reproductive function, and failure of pregnancy if kidney yin is deficient, consuming true yin or transforming heat, disturbing the Chong and ren meridians. The primordial sperm of the human beings and the spermatozoon are main substances for the development of the follicles, whether the yin essence is sufficient or not directly determines the quality of the follicles, if the yin essence is insufficient, the growth and the development of the follicles are abnormal, so that the ova cannot mature or have low quality, the embryo quality and the pregnancy outcome are further influenced, and the reduction of the ovary reserve function is caused by the deficiency of the kidney essence and the difficulty of sex-stimulating to fully satisfy the female reproductive function. Therefore, the treatment of this disease is mainly to tonify kidney and replenish essence, but most yin-tonifying herbs are greasy, and yang-warming and qi-tonifying herbs should be combined to tonify without retention. Blood and essence have the same source and are bred mutually, and the essence-replenishing adjuvant has the effect of replenishing blood and nourishing blood. Therefore, the pharmacology of the traditional Chinese medicine composition is to tonify the kidney and replenish essence, warm yang and tonify qi, nourish blood and soften liver. The Chinese medicinal composition has the following formulation:

monarch drug: prepared rehmannia root, white atractylodes rhizome. Prepared rehmannia root: sweet and warm in nature, it enters liver and kidney meridians. Nourish yin and enrich blood, supplement essence and replenish marrow. The herbal supplement: the traditional Chinese medicine is a main medicine for strengthening water. "meaning of pharmacy": prepared rehmannia root, radix rehmanniae Praeparata has the effects of benefiting heart blood and tonifying kidney water. It is indicated for internal injury, mental fatigue, blood injury, desire to consume essence, and menstruation and abortion. Tranquilize the five internal organs, harmonize the blood vessels, moisten the skin, nourish the heart spirit, tranquilize the soul, nourish the yin, and seal the bone marrow, which is also a holy drug. ' frying white atractylodes rhizome: bitter, sweet and warm, entering spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. The herbal tea is prepared in Ben Cao Tong Xuan (herbal tea for promoting urination): herbs that tonify spleen and stomach do not go beyond the right. It is also indicated for food failure, food stagnation and distension and fullness because it can strengthen the body's movement with vigorous soil. When the body is too strong, it can clear dampness, so it is also used for phlegm-fluid retention, swelling and damp arthralgia. The book Ben Cao Hui Yan (treatise on materia Medica): bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, is also the key herb for strengthening the spleen and stomach, dissipating dampness and removing arthralgia, promoting digestion and removing stuffiness. "the materia Medica: bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, bitter and sweet in taste, can dry dampness and strengthen spleen, and can relieve spleen and promote fluid production. Moreover, it is the warmest in nature, so it can be used as the first herb for spleen qi tonify to promote digestion and to eliminate food stagnation when taken. The combination of the two has the effects of replenishing vital essence and marrow, invigorating spleen and replenishing qi.

Ministerial drugs: semen Cuscutae, fructus Ligustri Lucidi, radix Glehniae, rhizoma Dioscoreae, radix Dipsaci, radix Codonopsis, and pericarpium Citri Tangerinae. Dodder seed: sweet and warm in nature, it enters liver, kidney and spleen meridians. Tonify liver and kidney, replenish essence, prevent abortion, and improve vision. The book Ben Cao Hui Yan: tu Si Zi also has the actions of tonifying kidney, nourishing liver, warming spleen and stomach. But it is not drastic but warm but not dry, so it enters kidney meridian, and can tonify deficiency, benefit, warm cold, cool heat, dry dampness and wet dryness. "(materia Medica of materia Medica): dodder is the top grade product for nourishing yin and dredging collaterals. It is slightly pungent in flavor, so it can keep yin with yang and move away, and is different from other yin-nourishing herbs which are greasy and stagnant. "(this Jing): "continue the wound, tonify deficiency, tonify qi, strengthen human body, nourish, all have the spirit of promoting blood circulation, warming and activating yang. "glossy privet fruit: sweet, bitter and cool, enter liver and kidney meridians. Nourishing liver and kidney, improving eyesight and blackening hair. The materia Medica treatment: nourishing yin qi, calming yin fire, relieving restlessness, and relieving bone-steaming. "(renewal of materia Medica): nourishing yin, tonifying kidney, invigorating qi and soothing liver. For lumbago and skelalgia, unblocking meridians and regulating blood. "(Ben Cao Jing Shu): "Zhen Zhi has both yin smell and heat-removing and essence-replenishing essence essential for kidney, so it is good at five zang organs, mental and general diseases and healthy . "radix glehniae: sweet, slightly bitter and slightly cold, entering lung and stomach meridians. To nourish yin, clear lung-heat, nourish stomach and promote fluid production. The book of Traditional Chinese Medicine (TCM) (J: it is indicated for fever due to consumptive disease, dry cough due to yin deficiency, thirst and dry throat. "Chinese yam: sweet and neutral in nature, they enter spleen, lung and kidney meridians. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. The book materia Medica is as follows: chinese yam can invigorate spleen, tonify deficiency, nourish essence and strengthen kidney, and treat consumptive disease and seven injuries. "(the book of materia Medica): the Chinese yam has the functions of tonifying kidney and replenishing essence, and the essence is sufficient to strengthen yin, improve eyesight and improve hearing. "teasel root: bitter and pungent with slight warm property enter liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, continue fracture and stop metrorrhagia and metrostaxis. The Yunnan herbal medicine: nourishing liver, strengthening tendons and bones, walking channels and collaterals, relieving soreness of meridians and collaterals, preventing miscarriage, treating leucorrhea, promoting blood circulation, and removing blood stasis. "(the summary of the present materia Medica): "Buxue Shengxue" (tonifying without stagnation) and moving without diarrhea), so it is often used in women and surgery. "dangshen: sweet and neutral in nature, they enter spleen and lung meridians. Tonify qi, strengthen spleen and nourish lung. The book of materia Medica: dangshen has the actions of tonifying spleen and stomach, moistening lung and promoting fluid production, and strengthening and transporting qi, and is not far from ginseng. Especially the more noble ones, it can invigorate the spleen but not dry, nourish stomach yin but not wet, moisten lung but not cold or cool, nourish blood but not greasy, inspire fresh yang, vibrate middle qi without the disadvantage of dryness. "dried orange peel: bitter, pungent and warm. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Compendium (compendium): orange peel, bitter in flavor and purging in property can dry, pungent in flavor and dispersing in property and warm in property. For all kinds of diseases, it is always used to regulate qi and dry dampness, tonics are used to tonify qi, purgatives are used to purge qi, ascending qi and descending qi. The spleen is the mother of original qi and the lung is the key of qi absorption, so orange peel is the key of qi of the two meridians, but it can tonify and purge ascending and descending along with it. The Chinese herbal medicines are used as ministerial medicines, and have the effects of tonifying liver and kidney, replenishing essence and marrow, tonifying qi and spleen, warming kidney and tonifying yang. Monarch and minister are compatible, yin and yang are supplemented, and essence and blood are supplemented.

Adjuvant drugs: angelica, fried white peony root, fried spina date seed and moutan bark. Chinese angelica: sweet, pungent and warm in property, enter liver, heart and spleen meridians. Tonify blood and activate blood, regulate menstruation and alleviate pain, moisten intestines and relax bowel. The book materia Medica is as follows: dang Gui is sweet and heavy in flavor, so it can tonify blood, and light and pungent in qi, so it can also move blood, tonify middle energizer and tonify middle energizer, and is good at qi in blood and holy herbs in blood. It is usually used as an assistant to tonify the body, so it can nourish yin and blood, tonify qi and produce essence, calm the five internal organs, strengthen the body and benefit the spirit, and is not suitable for diseases with physical deficiency. For those with excessive fire in yin, it is not advisable for Dang Gui to move and circulate blood, but for those with deficiency of yin and yang, Dang Gui can nourish blood. "Shen nong Ben Cao Jing Bai Zhong Lu (Shen nong's herbal records of hundreds of species): dang Gui is pungent and fragrant and moist, the fragrance moves the spleen, and the moistening tonifies blood, so it can penetrate into the middle energizer to nourish qi, and is the holy herb for nourishing qi. It is classified as essential herb for blood group. Stir-frying white paeony root: bitter and sour, slightly cold, entering liver and spleen meridians. Nourish blood and soften liver, relieve middle energizer and alleviate pain, astringe yin and astringe sweat. Tang Ben Cao (materia Medica of Tang Dynasty): "Yizixue". "(Rihuazi Ben Cao >): "treating all diseases of women and before and after delivery, promoting menstruation, relieving fever and restlessness, and invigorating qi" is recorded in the book of materia Medica of Cuckoo fur: for yin deficiency with yang hyperactivity, Bai Shao is used to tonify yin and yang. Parching semen Ziziphi Spinosae: sweet, sour and neutral, enter liver, gallbladder and heart meridians. Tonify liver, calm heart, arrest sweating and promote the production of body fluid. The original menstrual period was: semen Ziziphi Spinosae, when cooked, astringes semen, so it is indicated for insomnia due to gallbladder deficiency and polydipsia due to sweating due to deficiency. "Zhuzhenheng with clouds: for insomnia due to blood failing to enter spleen, it is advisable to use Ziziphus jujuba (Ziziphus jujuba) to tonify heart and spleen, so blood entering spleen and five zang-and-an-he, so that sleeping is easy. Tree peony bark: bitter and pungent with slight cold enter heart, liver and kidney meridians. Clear heat and cool blood, activate blood and resolve stasis. Moutan bark, cortex moutan has the actions of clearing blood and promoting blood circulation, so it has the actions of cooling blood and dissipating blood stasis, making blood flow smoothly without retaining blood stasis, and clearing blood heat without bleeding, so it is an essential herb for exuberance of blood heat, hyperactivity of liver and kidney fire and blood stasis. The herbal Zhenzhen: the root bark of peony tree, cortex moutan can purge fire in yin to reduce fire and promote yin generation, so it is used as an adjuvant to tonify yin. "(materia Medica): "harmonize blood, cool blood, generate blood, remove dysphoria with smothery sensation and promote blood circulation. Because stagnant heat is relieved by itself, it can also abate fever. For this reason, they can move blood without any serious symptoms. The four medicines are combined together to play the effects of nourishing blood, nourishing liver, assisting yin, clearing heat, calming heart and soothing nerves.

A messenger drug: bupleurum root: bitter and slightly cold. It enters liver and gallbladder meridians. To soothe the liver, relieve depression, and harmonize exterior, interior and yin-yang.

The whole formula has the effects of tonifying kidney and replenishing essence, warming yang and tonifying qi, nourishing blood and liver, clearing heat and calming heart. When the essence and blood are filled, the oocyte grows actively, develops and matures, and the ovarian function is improved; the essence can be passed through water, the women can pass through as usual, and the seeds are sometimes.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight and has the pharmacological effects:

20-35 parts of prepared rehmannia root, 15-35 parts of fried bighead atractylodes rhizome, 10-30 parts of Chinese yam, 10-20 parts of angelica, 10-20 parts of fried white peony root, 10-30 parts of fried spina date seed, 10-20 parts of moutan bark, 5-20 parts of radix bupleuri, 10-20 parts of teasel root, 10-20 parts of codonopsis pilosula, 10-20 parts of radix glehniae, 10-30 parts of semen cuscutae, 10-30 parts of glossy privet fruit and 5-20 parts of dried orange peel.

Prepared rehmannia root: sweet and warm. It enters liver and kidney meridians. To nourish yin, enrich blood, replenish essence and replenish marrow. Can be used for treating liver and kidney yin deficiency, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, menoxenia, metrorrhagia, metrostaxis, giddiness, tinnitus, and early white beard and hair. Typical but non-limiting amounts of prepared rehmannia root are: 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts and 35 parts.

Frying the bighead atractylodes rhizome: bitter, sweet and warm. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Typical but non-limiting amounts of roasted white atractylodes rhizome are: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts and 35 parts.

Chinese yam: sweet and neutral. It enters spleen, lung and kidney meridians. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, asthenic fever, and diabetes. Typical but non-limiting contents of yam are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts and 30 parts.

Chinese angelica: sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, etc. Typical but non-limiting contents of angelica are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Parching radix Paeoniae alba: bitter, sour and slightly cold. It enters liver and spleen meridians. Nourish blood and liver, relieve the middle energizer and alleviate pain, astringe yin and collect sweat. It is used to treat chest, abdomen, hypochondriac pain, dysentery, abdominal pain, spontaneous perspiration, night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, etc. Typical but non-limiting amounts of parched white peony root are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Parching semen Ziziphi Spinosae: sweet, sour and neutral. It enters liver, gallbladder and heart meridians. Tonify liver, calm heart, astringe sweat, promote fluid production. Can be used for treating vexation, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid deficiency, and thirst. Typical but non-limiting contents of parched semen Ziziphi Spinosae are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts and 30 parts.

Moutan bark: bitter, pungent and slightly cold. It enters heart, liver and kidney meridians. Clear heat and cool blood, activate blood and resolve stasis. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning cool, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, etc. Typical but non-limiting contents of moutan bark are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Bupleurum root: bitter and slightly cold. It enters liver and gallbladder meridians. Harmonize exterior and interior, soothe liver and raise yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, prolapse of son and sense organs, and proctoptosis. Typical but non-limiting amounts of bupleurum are: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Teasel root: bitter and pungent with mild warm nature. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, continue fracture and stop metrorrhagia and metrostaxis. Can be used for treating soreness of waist and knees, rheumatalgia, metrorrhagia, fetal leakage, and traumatic injury. Typical but non-limiting amounts of teasel are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Codonopsis pilosula: sweet and neutral. It enters spleen and lung meridians. Tonify middle-jiao and Qi, invigorate spleen and benefit lung. Can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes. Typical but non-limiting amounts of Codonopsis pilosula are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Radix glehniae: sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. To nourish yin, clear lung-heat, nourish stomach and promote fluid production. Can be used for treating lung heat dry cough, overstrain cough with phlegm and blood, fever with body fluid consumption and thirst. Typical, but non-limiting, amounts of glehnia littoralis are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

Dodder seed: sweet and warm. It enters liver, kidney and spleen meridians. Tonify liver and kidney, benefit essence and marrow, prevent miscarriage, improve eyesight, and check diarrhea. Can be used for treating sexual impotence, spermatorrhea, enuresis, frequent micturition, soreness of waist and knees, blurred vision, tinnitus, fetal leakage due to kidney deficiency, threatened abortion, and spleen and kidney deficiency. Typical, but non-limiting, contents of dodder are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts and 30 parts.

Glossy privet fruit: sweet, bitter and cool. It enters liver and kidney meridians. Nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating vertigo, tinnitus, soreness of waist and knees, premature gray hair, and dim eyesight. Typical but non-limiting contents of fructus ligustri lucidi are: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts and 30 parts.

Dried orange peel: bitter, pungent and warm. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating fullness in chest and epigastrium, anorexia, vomiting, diarrhea, cough, excessive phlegm, etc. Typical but non-limiting contents of dried orange peel are: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts.

The other embodiment of the invention is a medicine for treating the ovarian reserve function reduction, and the traditional Chinese medicine composition for treating the ovarian reserve function reduction and pharmaceutically acceptable auxiliary materials are processed into the medicine. The dosage form of the medicine is any one of granules, oral liquid, tablets, capsules, powder, pills and paste.

The technical solution of the present invention will be further described with reference to specific examples.

Example 1

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines by weight: 30 parts of prepared rehmannia root, 30 parts of fried bighead atractylodes rhizome, 15 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 10 parts of fried spina date seed, 10 parts of tree peony bark, 6 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 12 parts of codonopsis pilosula, 15 parts of coastal glehnia root, 15 parts of south dodder seed, 15 parts of glossy privet fruit and 9 parts of tangerine peel.

The preparation and administration method comprises the following steps: soaking the medicinal materials in clear water for half an hour, boiling with strong fire, decocting with slow fire for 30 min, decocting the first part, adding water, decocting for 20 min, decocting the second part, mixing the two decoctions, and taking the mixture twice in the morning and evening.

Example 2

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines by weight: 25 parts of prepared rehmannia root, 25 parts of fried bighead atractylodes rhizome, 10 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 10 parts of fried spina date seed, 10 parts of tree peony bark, 5 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 10 parts of codonopsis pilosula, 10 parts of coastal glehnia root, 15 parts of south dodder seed, 15 parts of glossy privet fruit and 5 parts of tangerine peel.

The preparation method comprises the following steps: weighing the above materials according to the dosage, adding water to immerse the materials, soaking for 3 hr, heating to boil, decocting for 0.5 hr, and collecting decoction. Decocting the residues by the method for 2-3 times, and mixing the decoctions. Filtering, concentrating by evaporation (1:1), cooling, adding 1.5 times of ethanol, mixing, standing overnight, collecting supernatant, washing precipitate with a little 50% ethanol, mixing the washing solution with the filtrate, recovering ethanol under reduced pressure, concentrating, cooling, standing, filtering, vacuum concentrating at low temperature to obtain soft extract with specific gravity of 1.33, spray drying, sieving with 300 mesh sieve, adding appropriate amount of adjuvants, and making into granule.

Example 3

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines by weight: 35 parts of prepared rehmannia root, 35 parts of fried bighead atractylodes rhizome, 20 parts of Chinese yam, 15 parts of Chinese angelica, 15 parts of fried white peony root, 20 parts of fried spina date seed, 15 parts of tree peony bark, 10 parts of Chinese thorowax root, 20 parts of teasel root, 15 parts of codonopsis pilosula, 20 parts of radix glehniae, 20 parts of dodder, 20 parts of glossy privet fruit and 10 parts of dried orange peel.

The preparation method comprises the following steps: weighing the above medicinal materials according to the dosage, pulverizing three fifths of the medicinal materials, sieving with a 50 mesh sieve, adding water to immerse the medicinal materials, soaking for 3 hr, heating to boil, decocting for 0.5 hr, and collecting decoction. Decocting the residue by the method for 2-3 times, and mixing decoctions. Filtering, concentrating by evaporation (1:1), cooling, adding 1.5 times of ethanol, mixing, standing overnight, collecting supernatant, washing precipitate with a little 50% ethanol, mixing the washing solution with the filtrate, recovering ethanol under reduced pressure, concentrating, cooling, standing, filtering, vacuum concentrating at low temperature to obtain soft extract with specific gravity of 1.33, spray drying, grinding, sieving with 300 mesh sieve to obtain extract powder, and making into capsule.

Example 4

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines by weight: 30 parts of prepared rehmannia root, 30 parts of fried bighead atractylodes rhizome, 20 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 15 parts of fried spina date seed, 10 parts of tree peony bark, 10 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 15 parts of codonopsis pilosula, 15 parts of coastal glehnia root, 20 parts of south dodder seed, 15 parts of glossy privet fruit and 9 parts of tangerine peel.

The preparation method comprises the following steps: weighing the raw materials according to the weight, drying, micronizing to obtain particles above 800 meshes, adding appropriate amount of dextrin, stirring, and making into tablet.

Example 5

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines in parts by weight: 30 parts of prepared rehmannia root, 30 parts of fried bighead atractylodes rhizome, 15 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 10 parts of fried spina date seed, 10 parts of tree peony bark, 6 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 12 parts of codonopsis pilosula, 15 parts of coastal glehnia root, 15 parts of south dodder seed, 15 parts of glossy privet fruit and 9 parts of tangerine peel.

The preparation method comprises the following steps: weighing the raw materials according to the weight, soaking the raw materials in clear water for half an hour, boiling the raw materials with strong fire, then decocting the raw materials with slow fire for 30 minutes, taking the first decoction, adding water, decocting the first decoction for 20 minutes, taking the second decoction, uniformly mixing the two decoctions to obtain decoction, and taking the decoction twice in the morning and at night. Then adding appropriate amount of Camphora into the decocted medicinal residue, wrapping with towel, and making into hot compress agent. The lower abdomen is heated for 30 minutes, preferably hot rather than hot. The towel is coated with a hot water bag to keep the temperature at about 40 ℃. Once a day.

Example 6

A traditional Chinese medicine composition for treating ovarian reserve function reduction comprises the following raw material medicines by weight: 25 parts of prepared rehmannia root, 25 parts of fried bighead atractylodes rhizome, 15 parts of Chinese yam, 15 parts of Chinese angelica, 10 parts of fried white peony root, 15 parts of fried spina date seed, 12 parts of tree peony bark, 10 parts of Chinese thorowax root, 15 parts of teasel root, 15 parts of codonopsis pilosula, 15 parts of radix glehniae, 20 parts of dodder, 15 parts of glossy privet fruit and 10 parts of dried orange peel.

The preparation method comprises the following steps: weighing the above materials according to the dosage, adding water to immerse the materials, soaking for 3 hr, heating to boil, decocting for 0.5 hr, and collecting decoction. Decocting the residue by the method for 2-3 times, and mixing decoctions. Filtering, concentrating by evaporation (1:1), cooling, adding 1.5 times of ethanol, mixing, standing overnight, collecting supernatant, washing precipitate with a small amount of 50% ethanol, mixing the washing solution with the filtrate, recovering ethanol under reduced pressure, concentrating, cooling, standing, filtering, and vacuum concentrating at low temperature to obtain fluid extract with specific gravity of 1.20-1.35; drying the second residue, pulverizing into fine powder as additive, mixing with the fluid extract with a specific gravity of 1.20-1.35, and spray drying with water vapor gas or nitrogen gas as atomizing gas to obtain medicinal powder granule.

Clinical trial

1. Study object

60 patients with ovarian reserve function reduction diagnosed in the first hospital reproductive center in Ningbo city are selected, and the treatment groups are divided into 30 patients and 30 patients in the control group according to whether the treatment is carried out by a kidney nourishing and meridian benefiting method. The mean ages of the two groups of patients are (31.43 +/-3.93) and (31.83 +/-3.90), and the difference is not statistically significant (P is more than 0.05). The infertility years and BMI of two groups of patients have no statistical difference (P is more than 0.05), and the two groups of patients have comparability.

2. Execution standard and method

(1) Diagnostic criteria

DOR diagnostic criteria were as follows: (a) age: female aged 20-40 years old; (b) anti-mullerian hormone (AMH) levels: AMH is less than or equal to 3.0ng/ml for 20-25 years old, AMH is less than or equal to 2.5ng/ml for 26-30 years old, AMH is less than or equal to 1.5ng/ml for 31-35 years old, and AMH is less than or equal to 1.0ng/ml for 36-40 years old; (c) the number of basic antral follicles (bAFC) is less than or equal to 5 (on the 2-5 th day of menstruation). The term (a) is a requirement, and the term (b) and the term (c) are secondary conditions, and any one of the requirement and the secondary condition is satisfied, and the DOR diagnosis can be made.

(2) The treatment method comprises the following steps:

treatment groups: 30g of prepared rehmannia root, 30g of fried bighead atractylodes rhizome, 15g of Chinese yam, 10g of Chinese angelica, 10g of fried white peony root, 10g of fried spina date seed, 10g of tree peony bark, 6g of Chinese thorowax root, 15g of himalayan teasel root, 12g of codonopsis pilosula, 15g of coastal glehnia root, 15g of south dodder seed, 15g of glossy privet fruit and 9g of tangerine peel. The decoction is taken by water, one dose is taken every day, and the decoction is taken in the morning and the evening. Each menstrual cycle is 1 course, and the treatment course is 3.

Control group: coenzyme Q10, 10mg once, 3 times a day, was administered after meals.

(3) Observation indicator and method

Firstly, ovarian function indexes: anti-mullerian hormone (AMH);

② clinical symptom indexes: menstrual and clinical symptom improvement;

safety evaluation indexes: adverse reactions, adverse events and side effects are clinically observed, recorded or reported in time, and information such as the occurrence time, symptoms and physical signs of the adverse events, whether medication is used for relieving or not, the time for relieving or not, whether therapeutic measures are used for causing or not and the like is recorded in detail.

(4) Clinical efficacy evaluation criteria

Is made according to the Chinese medicine industry standard of the people's republic of China-the Chinese medicine gynecological disease diagnosis curative effect standard.

Firstly, curing: the menstrual amount, menstrual period and cycle are recovered to be normal, and clinical symptoms basically disappear;

improvement: the menstrual amount, menstrual period and period are approximately recovered to be normal, and the clinical symptoms are improved;

③ invalid: the symptoms are not obviously improved.

(5) Statistical method

Statistical description and analysis data processing was performed using SPSS 22.0 statistical software. The measured data conforms to the normal distribution

Expressing that the measured data does not conform to the normal distribution and adopts M (P25, P75), and adopting t test when the measured data conforms to the normal distribution and adopting rank sum test when the measured data does not conform to the normal distribution; counting data are described by frequency and percentage, and binary data are compared between groups by adopting a chi 2 test or a Fisher test of exact probability. P<A difference of 0.05 is statistically significant.

3. Results of the study

(1) Index of ovarian function

As shown in Table 1, compared before and after treatment of blood AMH in two groups, the difference between the blood AMH (1.00 +/-0.72) ng/ml before treatment in the treatment group and the difference between the blood AMH (1.12 +/-0.73) ng/ml in the control group are not statistically significant (P is more than 0.05), and the differences are comparable. After treatment, the blood AMH (1.76 +/-1.29) ng/ml of the treatment group and the ng/ml of the control group (1.46 +/-0.97) are increased compared with the blood AMH before treatment, the difference is statistically significant (P is less than 0.05), but compared with the two groups without statistical difference (P is more than 0.05), the increase amplitude after treatment of the treatment group is larger than that of the control group.

TABLE 1 comparison of AMH before and after treatment of the two groups

(2) Clinical symptoms

As shown in Table 2, the clinical symptoms of the two groups of patients after treatment are generally improved, the cure rate is 33.3%, the improvement rate is 60.0%, and the clinical symptoms of 6.7% of patients have no obvious change. The cure rate of the control group is 3.3%, the improvement rate is 30.0%, 66.7% of patients have no obvious improvement on symptoms, and the difference between the two groups has statistical significance (P < 0.05).

Table 2 two-group clinical symptom comparison n (%)

(3) Safety evaluation index

No obvious adverse reaction is seen in the two groups.

The research result shows that: the traditional Chinese medicine compound can improve the ovarian function and clinical symptoms of patients, has no obvious adverse reaction, and has better safety.

Typical case

Case 1: cao was a female, 28 years old, married. The main complaints are: no contraception was performed and no further pregnancy occurred for 2 years. The current medical history: marriage 3 years, biochemical treatment 1 time in 2019, and no recygiency after contraception. Pinsu is advanced in menstruation, has a cycle of 23 days, has little dosage, is red in color, has blood clots (-) and has dysmenorrhea (-). The last menstruation: 8/2021. Blood AMH at 6 months in 2021: 0.08ng/ml, FSH: 10.56 IU/L. The salpingography indicates that the two fallopian tubes are unobstructed and the uterine adnexa is not obviously abnormal. No abnormality is found in sperm examination of male. The patients see a doctor in my department in 8 months and 17 days in 2021, and the disease is marked as follows: soreness and weakness of the waist and knees, dry throat, thirst, restlessness, difficulty in receiving, and a red tongue with yellowish root. The syndrome belongs to the syndrome of kidney essence deficiency, and the main therapeutic principle is tonifying kidney and replenishing essence. The method comprises the following steps: 30g of prepared rehmannia root, 30g of fried bighead atractylodes rhizome, 15g of Chinese yam, 15g of Chinese angelica, 10g of fried white peony root, 10g of fried spina date seed, 10g of tree peony bark, 6g of Chinese thorowax root, 15g of teasel root, 12g of codonopsis pilosula, 15g of coastal glehnia root, 15g of south dodder seed, 15g of glossy privet fruit and 9g of dried orange peel. Order patients to adjust life style, enhance exercise, prepare for pregnancy as soon as possible, and be unsuitable for follow-up diagnosis. The addition and subtraction of the medicines are carried out on the basis of the upper part according to the symptom change of the patient during the re-diagnosis, and the blood AMH is re-examined after 3 months of treatment: 0.36 ng/ml, FSH: 9.37 IU/L. The patient self-tests the urine TT (+) in 27 days after 11 months, and the traditional Chinese medicine treats the disease to tonify the kidney and prevent abortion. 12 month, 14 day 2021 ultrasonic B prompt: single live fetus in uterus.

Case 2: li Shi, female, age 32, married. The main complaints are: no contraception and 4 years of infertility. The current medical history: marrying for 6 years, and non-contraceptive and non-pregnancy for 4 years after contraception is relieved. Irregular menstruation, cycle 25-40 days, 4 days of menstrual period, low volume, dark color, blood clot (-), dysmenorrhea (-), last menstruation: 1 month and 25 days 2021. AMH of 11 months in 2019: 0.32ng/ml, FSH: 15.5IU/L, if the ovary reserve function is reduced, IVF-ET assisted pregnancy is carried out, 2 eggs are respectively taken in 5-month 2-month and 6-month 29-month 2020, and the eggs are not prepared and are about to be taken again. Reexamination of AMH in 7 months in 2020: 0.19ng/ml, FSH: 18.45 IU/L. The sperm of the male is checked normally. The patients have a diagnosis in my department within 3 months and 2 days in 2021, and the following symptoms are seen: soreness and weakness of the loins and knees, impatience and dry throat, insomnia and dreamful sleep, feverish sensation in the palms and soles, and red tongue. The syndrome belongs to the syndrome of kidney essence deficiency, and the main therapeutic principle is tonifying kidney and replenishing essence. The method comprises the following steps: 30g of prepared rehmannia root, 30g of fried bighead atractylodes rhizome, 15g of Chinese yam, 15g of Chinese angelica, 10g of fried white peony root, 10g of fried spina date seed, 10g of tree peony bark, 6g of Chinese thorowax root, 15g of teasel root, 12g of codonopsis pilosula, 15g of radix glehniae, 15g of Chinese dodder seed, 15g of glossy privet fruit and 9g of dried orange peel, and the raw materials are decocted with water for taking, and one dose is taken every day and taken in the morning and evening. Order the patient to adjust the life style, prepare for pregnancy as soon as possible, and be unsuitable for follow-up diagnosis. The medicine is added or subtracted on the basis of the above according to the symptom change of a patient during the return visit, 3 eggs are taken in 8 months and 17 days after 4 months of treatment, 2 eggs are prepared, and 1 blastocyst is obtained. The patient wants to take eggs again, and then continues conditioning and instructs the pregnancy test, and the patient rechecks blood for 10 months in 2021, AMH: 0.23ng/ml, FSH: 11.88 IU/L. The patient self-tests the urine TT (+) after 10 months and 30 days, and the traditional Chinese medicine is used for tonifying the kidney and preventing miscarriage. 11/2021, 13/month, B-ultrasonic: single live fetus in uterus.

Although the present disclosure has been described above, the scope of the present disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present disclosure, and such changes and modifications will fall within the scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating ovarian reserve function reduction is characterized by being prepared from the following raw material medicines in parts by weight: 20-35 parts of prepared rehmannia root, 15-35 parts of fried bighead atractylodes rhizome, 10-30 parts of Chinese yam, 10-20 parts of angelica, 10-20 parts of fried white peony root, 10-30 parts of fried spina date seed, 10-20 parts of moutan bark, 5-20 parts of radix bupleuri, 10-20 parts of teasel root, 10-20 parts of codonopsis pilosula, 10-20 parts of radix glehniae, 10-30 parts of semen cuscutae, 10-30 parts of glossy privet fruit and 5-20 parts of dried orange peel.

2. The traditional Chinese medicine composition for treating ovarian reserve function reduction according to claim 1, is characterized by being prepared from the following raw material medicines in parts by weight: 25-35 parts of prepared rehmannia root, 25-35 parts of fried bighead atractylodes rhizome, 10-20 parts of Chinese yam, 10-15 parts of angelica sinensis, 10-15 parts of fried white peony root, 10-20 parts of fried spina date seed, 10-15 parts of moutan bark, 5-10 parts of radix bupleuri, 15-20 parts of teasel root, 10-15 parts of codonopsis pilosula, 10-20 parts of radix glehniae, 15-20 parts of semen cuscutae, 15-20 parts of glossy privet fruit and 5-10 parts of dried orange peel.

3. The traditional Chinese medicine composition for treating ovarian reserve function reduction according to claim 1, which is prepared from the following raw material medicines in parts by weight: 30 parts of prepared rehmannia root, 30 parts of fried bighead atractylodes rhizome, 15 parts of Chinese yam, 10 parts of Chinese angelica, 10 parts of fried white paeony root, 10 parts of fried spina date seed, 10 parts of tree peony bark, 6 parts of Chinese thorowax root, 15 parts of himalayan teasel root, 12 parts of codonopsis pilosula, 15 parts of coastal glehnia root, 15 parts of south dodder seed, 15 parts of glossy privet fruit and 9 parts of tangerine peel.

4. The composition of claim 1, comprising a pharmaceutically acceptable carrier for the treatment of reduced ovarian reserve.

5. Use of a Chinese medicinal composition according to any one of claims 1 to 4 in the preparation of a medicament for the treatment of reduced ovarian reserve function.

6. The use of claim 5, wherein the medicament is in the form of granules, oral liquid, tablets, capsules, powders, pills or creams.