CN109549984B

CN109549984B - Traditional Chinese medicine composition for treating infertility

Info

Publication number: CN109549984B
Application number: CN201910041775.6A
Authority: CN
Inventors: 田景永
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-01-16
Filing date: 2019-01-16
Publication date: 2021-05-28
Anticipated expiration: 2039-01-16
Also published as: CN109549984A

Abstract

A Chinese medicinal composition for treating infertility belongs to the technical field of traditional Chinese medicine, and is prepared from radix Codonopsis, Cistanchis herba, caulis Sargentodoxae, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae alba, radix rehmanniae Preparata, cortex moutan, ramulus Cinnamomi, and Massa Medicata Fermentata; the traditional Chinese medicine composition has the beneficial effects that the codonopsis pilosula, the cistanche and the sargentgloryvine stem are combined to be used as monarch medicine, so that the traditional Chinese medicine composition can replenish qi and blood, warm kidney yang and dredge channels; angelica, ligusticum wallichii, white paeony root and prepared rhizome of rehmannia are used as ministerial drugs and as blood enriching basic formulas; the cassia twig and the cortex moutan are used as adjuvant drugs, the cassia twig helps a monarch drug to dredge the channels and dispel cold, and the cortex moutan relieves dryness of warm and hot property of various drugs and clears damp-heat in lower energizer; medicated leaven is used as a messenger drug to strengthen the spleen and stomach and promote the absorption of the drug; the medicines are combined to play the effects of tonifying qi and nourishing blood, clearing and activating the channels and collaterals, warming the kidney and dispelling cold, and clearing and removing dampness and heat in lower jiao; and prepares the medicine related to the symptoms, is especially suitable for infertility caused by deficiency of qi and blood, deficiency of kidney qi, damp-heat in lower-jiao and the like, and is suitable for mass production, popularization and application.

Description

Traditional Chinese medicine composition for treating infertility

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating infertility.

Background

Medically, a couple of childbearing age who is not pregnant after one year or more of marrying is generally called infertility. There are three clinical situations: firstly, the non-pregnant person who has normal sexual life and is not contraceptive for 1 year is called infertility; ② the one who has not contraceptive but has never been pregnant after marriage for 1 year is called primary infertility; and the infertile people who have been pregnant and then have not been contraceptive for 1 year are called secondary infertility.

At present, a plurality of methods for treating infertility are available, and the methods mainly comprise western medicine treatment and traditional Chinese medicine treatment. Western medicine treatment mainly comprises drug treatment and operative treatment, wherein the drug treatment mainly regulates hormone level, is easy to cause endocrine dyscrasia to cause other diseases, the antibiotic treatment is used for treating inflammation of reproductive system, the long-time and large-dose use of the antibiotic is easy to cause dyscrasia of flora and damage to liver and kidney functions, and many antibiotics have the defect of fetal malformation. And many patients are not effectively treated by western medicine. The operation treatment is mainly artificial pregnancy and test tube babies, but is only carried out in a few large hospitals at present, the cost is high, and much inconvenience and heavy economic burden are brought to families of patients.

In the aspect of traditional Chinese medicine, according to the view point of traditional Chinese medicine: infertility belongs to the category of kidney deficiency, and the kidney is the congenital source and stores essence. The main reproductive development, congenital endowment deficiency, acquired daily living disorder, overwork, emotional discomfort, sexual overstrain and other factors damage kidney qi, so that male kidney essence deficiency, female thoroughfare and conception vessel deficiency and uterus malnutrition are caused, the basic pathogenesis of infertility is that kidney is closely related to heart and liver, and the clinical pathological manifestations are symptoms of liver and kidney deficiency, heart and kidney imbalance and the like, so that the treatment of the infertility is based on the principle of conditioning yin and yang and qi and blood of heart, liver and kidney, and is based on the excess of qi and blood and yin and yang to respectively supplement qi, nourish blood, nourish yin, strengthen yang and the like, and the prescription is performed according to the principle. For example, patent document CN 103272162a discloses a Chinese medicinal composition for treating infertility and its preparation method, wherein the composition is prepared from herba Leonuri, radix Codonopsis, herba Epimedii, radix Angelicae sinensis, radix rehmanniae Preparata, pericarpium Citri Reticulatae, radix Linderae, radix astragali, rhizoma Chuanxiong, rhizoma Atractylodis Macrocephalae preparata with bran, rhizoma Cyperi preparata with vinegar, Poria, radix aucklandiae, folium Perillae, colla Corii Asini, fructus Amomi, radix Scutellariae, Succinum, radix Glycyrrhizae, lignum Aquilariae Resinatum, radix Cyathulae, and fructus Lycii, and has effects of promoting qi circulation and blood circulation for regulating qi and blood of female, replenishing essence and marrow, promoting urination, invigorating kidney yang, and nourishing kidney for male, and can be administered together by female and male. Patent document CN 108619441a discloses a pharmaceutical composition for treating infertility, and a preparation method and application thereof, wherein the pharmaceutical composition is prepared from fructus lycii, semen cuscutae, ginseng, cinnamon, fructus alpiniae oxyphyllae, longan, raspberry, herba epimedii, rhizoma curculiginis and morinda officinalis for tonifying middle-jiao and draining diarrhea, nourishing yin and strengthening yang for tonifying kidney and replenishing vital essence, filling vital essence, and improving congenital deficiency of kidney essence for treating infertility. Patent document CN 103989803a discloses a traditional Chinese medicine for treating infertility, which adopts eucommia bark, cinnamon, raw astragalus root, dodder, ginseng, magnolia bark, asarum, prepared rehmannia root and raw licorice to strengthen the body resistance, strengthen the body resistance and eliminate pathogenic factors, tonify qi and raise yang, nourish yin and enrich the blood, replenish vital essence and marrow, tonify spleen and lung, consolidate fetus and stop diarrhea, activate blood and dredge channels to promote conception.

The medicines are prepared from the aspects of tonifying the kidney or activating blood and qi, the systemic reason is not considered, and the medicines are effective only when the patients have infertility caused by kidney deficiency or deficiency of qi and blood. However, this is likely to neglect the comprehensive regulation and treatment of diseases of the waist (house of kidney) and inflammations of the reproductive system (damp-heat in the lower-jiao), and thus many of them have poor curative effects. In fact, most patients do not only have a partial condition, but a combination of many causes. Kidneys are water-zang organs and located in the lower-jiao to control water and open and close, so as to maintain water metabolism of human body, and if the qi transformation of kidneys is abnormal, the water metabolism is unbalanced, so that the damp-heat in the lower-jiao is easily caused; the waist is the house of the kidney, modern people often sit and stay up for a long time due to the reason of work, and the modern people lack exercise and exercise, so that the diseases of the muscles and bones of the waist are ubiquitous, and therefore, the treatment needs to consider the problems of the kidney deficiency and qi and blood, pay attention to simultaneously regulating and treating the diseases of the waist, dredging the meridians of the waist and clearing damp-heat in the lower energizer, so that the comprehensive treatment can be realized, and the good effect can be obtained. The present invention has been made in view of the above circumstances.

Disclosure of Invention

The invention aims to overcome the defects of the traditional Chinese medicine for treating infertility, provides a traditional Chinese medicine composition product which has the effects of simultaneously benefiting qi and nourishing blood, clearing and activating the channels and collaterals, warming kidney and dispelling cold and clearing damp-heat in lower jiao, is particularly suitable for treating infertility caused by multiple reasons of qi and blood deficiency, kidney qi deficiency, cold evil face and lower jiao damp-heat, is suitable for treating various types of infertility and improves the success rate of infertility treatment.

In order to achieve the purpose, the technical scheme adopted by the invention is a traditional Chinese medicine composition for treating infertility, which is characterized in that codonopsis pilosula, cistanche, sargentgloryvine stem, angelica, ligusticum wallichii, white paeony root, prepared rhizome of rehmannia, cortex moutan, cassia twig and medicated leaven are used as raw materials in a compatible way.

In the formula, the codonopsis pilosula is used for tonifying middle-jiao energy, the cistanche is used for warming and invigorating kidney yang and replenishing essence and blood, and the sargentgloryvine stem is used for promoting blood circulation and removing obstruction in channels, and the three medicines are combined to replenish qi and blood, warm kidney yang and dredge channels and collaterals to be monarch medicines; the Chinese angelica and the szechuan lovage rhizome have the effects of enriching blood and activating blood, the white paeony root has the effects of nourishing yin and softening liver, relieving spasm and pain, and the prepared rehmannia root has the effects of tonifying kidney and replenishing essence; the cassia twig warms the channels and promotes blood circulation, and assists yang and regulates qi, thereby not only assisting the sargentgloryvine stem in clearing and activating the channels and collaterals, but also expelling cold evil; cortex moutan enters heart, liver and kidney meridians, and has effects of clearing heat, cooling blood, promoting blood circulation, removing blood stasis, relieving dryness of various herbs, and clearing damp-heat in lower energizer, so ramulus Cinnamomi and cortex moutan are used as adjuvant drugs; medicated leaven is prepared from herba Polygoni Hydropiperis, herba Artemisiae Annuae, herba Xanthii, semen Phaseoli, semen Armeniacae amarum, and testa Tritici; has effects in invigorating spleen, regulating stomach function, promoting digestion, and regulating middle warmer; can be used for treating weakness of spleen and stomach, diet stagnation, chest distress, abdominal distention, and infantile dyspepsia; can prevent the medicine from damaging the spleen and stomach and promote the absorption of the medicine, and is used as a messenger medicine; the traditional Chinese medicine composition has the effects of tonifying qi and nourishing blood, clearing and activating the channels and collaterals, warming the kidney and dispelling cold, and clearing and removing dampness and heat in the lower jiao, and has a good treatment effect on infertility caused by various reasons of qi and blood deficiency, kidney qi deficiency, cold evil face and dampness and heat in the lower jiao.

The specific scheme is that the traditional Chinese medicine composition for treating infertility is prepared from the following raw material medicines in parts by mass: 30-70 parts of codonopsis pilosula, 15-50 parts of cistanche, 30-70 parts of sargentgloryvine stem, 20-50 parts of angelica, 5-20 parts of ligusticum wallichii, 10-30 parts of radix paeoniae alba, 15-45 parts of radix rehmanniae preparata, 30-80 parts of cortex moutan, 5-20 parts of cassia twig and 5-15 parts of medicated leaven; is a universal progestational medicine.

Generally, patients suffering from infertility mostly have comprehensive symptoms and mainly show symptoms such as deficiency of qi and blood, damp-heat in lower jiao, deficiency of kidney qi, cold evil squat and the like, and the preferable scheme is that the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the composition is a comprehensive pregnancy-promoting medicine.

When the symptoms of deficiency of qi and blood are relatively prominent, 5 parts of angelica can be added; namely the raw material medicaments: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 35 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven are qi and blood deficiency type pregnancy-promoting medicines.

When the lower-jiao damp-heat symptom is relatively prominent, 8 parts of cortex moutan can be added; namely the raw material medicaments: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 58 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the medicine is a damp-heat type pregnancy-promoting medicine.

When kidney qi deficiency is eliminated and cold evil discopathy is relatively prominent, 5 parts of cistanche deserticola can be added, namely the raw material medicaments comprise: 50 parts of codonopsis pilosula, 35 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the medicine is a deficiency-cold type pregnancy-promoting medicine.

The product form of the traditional Chinese medicine composition can adopt dosage forms of oral liquid, electuary, tablets, capsules, granules, water-bindered pills, honeyed pills and the like.

The oral liquid is prepared by the following method.

Weighing the raw materials according to the proportion, adding water which is 6-10 times of the total weight of the traditional Chinese medicines, decocting for 2-4 times, wherein the decocting time is 1-3 hours each time, combining the decoctions, filtering, concentrating, and containing the filtrate according to 100ml per vial to obtain the oral liquid product.

The granule is prepared by the following method.

Weighing the raw materials according to the proportion, adding water which is 6-10 times of the total weight of the traditional Chinese medicines, decocting for 1-3 times, wherein the decocting time is 1-3 hours each time, combining the decoctions, filtering, concentrating, drying, crushing, sieving to obtain powder with the particle size of less than 100 meshes, and subpackaging according to 6 g per small packet to obtain the electuary product.

The honeyed pill is prepared by the following method.

Weighing the traditional Chinese medicine raw materials according to the proportion, respectively grinding the raw materials into powder, sieving the powder to obtain powder below 100 meshes, uniformly mixing the powder, mixing the honey with equal mass with the mixed powder, rubbing the mixture into strips, making pills, preparing honeyed pills, and subpackaging the honeyed pills according to 12 g per small package to obtain the honeyed pill product.

Or mixing the powder with pharmaceutically acceptable carrier and/or excipient, and making into capsule, tablet, granule or pill.

The Chinese medicinal composition of the invention has various dosage forms which are oral preparations, is used for treating infertility caused by various reasons, and needs to be taken by both couples at the same time.

Taking oral liquid as an example, the oral dosage is 100 ml/time, namely one vial each time, 4 times/day, and one treatment course in half a month; taking granules as an example: the dosage of the oral granule is 6 g/time, namely one packet each time and 4 times/day, the granule is taken with boiled water and warm water, and a treatment course is 15 days in half a month. The oral honeyed pill is 12 g/time, namely one small bag each time, 4 times/day, and is taken with warm water, and a treatment course is half a month. The same room is forbidden during taking medicine, so as to avoid fatigue. The time for taking the medicine is different according to individual difference, and the pregnant woman can be pregnant after taking the medicine for 2-8 months.

During actual treatment, corresponding medicines are generally prepared and taken according to different symptoms of a couple, for example, when qi and blood are insufficient on one party and damp-heat is in the lower jiao on the other party, a pregnancy promoting medicine with qi and blood deficiency and a pregnancy promoting medicine with damp-heat in the lower jiao are prepared respectively, and after conditioning for a period of time, comprehensive pregnancy promoting medicines are prepared and taken; or when one party is dampness-heat in lower jiao and the other party is squat with kidney qi deficiency and cold evil, the medicine is respectively taken with dampness-heat type pregnancy promoting medicine and deficiency-cold type pregnancy promoting medicine, and the comprehensive pregnancy promoting medicine is taken after conditioning for a period of time; or when one party is deficient in qi and blood, the other party is deficient in kidney qi, and cold evil is face-laid, the qi and blood deficiency type pregnancy promoting medicine and the deficiency-cold type pregnancy promoting medicine are respectively taken firstly, and the comprehensive pregnancy promoting medicine is taken after conditioning for a period of time; therefore, the Chinese patent medicine component can be prepared from the Chinese patent medicine component which is formed by combining the dosage of 1-3 courses of qi and blood deficiency type pregnancy promoting medicines, the dosage of 1-3 courses of damp-heat type pregnancy promoting medicines, the dosage of 1-3 courses of deficiency-cold type pregnancy promoting medicines and the dosage of 1-5 courses of comprehensive type pregnancy promoting medicines.

In the above, the dosage of the treatment course is a metering and time distribution unit. When the oral liquid progestational drug is taken, the dosage in one treatment course is 100ml for 4 times a day and is the dosage for half a month; i.e. 60 vials of oral liquid. When the honeyed pill pregnancy promoting medicine is taken, the dosage of one treatment course is 12 g per time and 4 times a day, and the dosage is half a month; namely 720 g honeyed pills. When the granule pregnancy promoting medicine is taken, the dosage of one treatment course is 4 times a day, 6 g each time and half a month; i.e. 360 g of infusion. The dosage of the other dosage forms can be executed according to the reference.

The invention has the advantages that the codonopsis pilosula, the cistanche deserticola and the sargentgloryvine stem are combined as monarch drug, which can replenish qi and blood, warm kidney yang and dredge channels; angelica, ligusticum wallichii, white paeony root and prepared rhizome of rehmannia are used as ministerial drugs and as blood enriching basic formulas; the cassia twig and the cortex moutan are used as adjuvant drugs, the cassia twig helps a monarch drug to dredge the channels and dispel cold, and the cortex moutan relieves dryness of warm and hot property of various drugs and clears damp-heat in lower energizer; medicated leaven is used as a messenger drug to strengthen the spleen and stomach and promote the absorption of the drug; the traditional Chinese medicine composition has the advantages of reasonable formula, treatment of both symptoms and root causes, obvious curative effect and low price, has a good treatment effect on infertility caused by various reasons, is especially suitable for infertility caused by deficiency of qi and blood, deficiency of kidney qi, dampness and heat in lower jiao and the like, is prepared into medicines related to the prominent symptoms, is convenient to take, and is suitable for mass production and popularization and application.

Detailed Description

The present invention is further illustrated by the following examples, which are intended to illustrate the invention but not to limit it further, and should not be construed as limiting the scope of the invention.

Example 1.

Preparing traditional Chinese medicine composition powder electuary for treating infertility, wherein 30kg of codonopsis pilosula, 15kg of cistanche, 30kg of sargentgloryvine stem, 20kg of angelica, 5kg of ligusticum wallichii, 10kg of radix paeoniae alba, 15kg of radix rehmanniae preparata, 30kg of cortex moutan, 5kg of cassia twig and 5kg of medicated leaven are taken; adding 10 times of 1650kg of clear water, soaking for 30 min, boiling with strong fire, stewing with slow fire for 90-100 min, and filtering to obtain filtrate; then putting the dregs into 8 times of 1320kg of clear water, boiling with big fire, stewing with small fire for 55-65 minutes, filtering and taking liquid; then putting the dregs into 990kg of clear water which is 6 times the amount of the dregs, stewing the dregs for 30-35 minutes by small fire after boiling by big fire, and filtering the dregs to obtain liquid; and merging the decoctions for three times, concentrating, drying, crushing, sieving by a 100-mesh sieve to obtain powder, and subpackaging the powder according to 6 g per small bag to obtain the universal pregnancy promoting powder.

[ usage amount ]: the medicine is taken 4 times a day, 6 g each time, is infused with boiled water and is taken with warm water half an hour before and after a meal, and 30 days is a course of treatment.

[ accommodation range ]: various infertility symptoms.

[ Note ] that: it should be used with cautions for patients with hypertension and hyperglycemia, and should not be used for patients with heart disease, severe hypertension, and diabetes.

[ contraindication ]: the same room is forbidden during taking medicine, so as to avoid fatigue.

The time for taking the medicine is different according to individual difference, and the pregnant woman can be pregnant after taking the medicine for 2-8 months.

Example 2.

Preparing a traditional Chinese medicine composition oral liquid for treating infertility suitable for syndromes such as qi and blood deficiency, lower-jiao damp-heat, kidney qi deficiency, cold evil squat and the like, wherein 10kg of dried radix codonopsis pilosulae, 6kg of cistanche, 10kg of sargentgloryvine stem, 6kg of angelica, 2kg of ligusticum wallichii, 4kg of radix paeoniae alba, 6kg of radix rehmanniae preparata, 10kg of cortex moutan, 2kg of cassia twig and 2kg of medicated leaven are taken; respectively pulverizing into fine powder with a pulverizer, sieving with a 100-mesh sieve, and mixing to obtain mixed powder for later use. Taking honey which is 1.3-1.5 times of the total weight of the mixed powder, taking 80kg of honey at this time, and then refining the honey, namely boiling the honey with big fire, then decocting with small fire for 25-30 minutes, heating to 116-118 ℃, and when the foam is light red and glossy, twisted with hands and sticky but can not be pulled into long white filaments, simultaneously dripping a drop of honey into cold water to form beads, thus obtaining refined honey; then 65.5kg of refined honey is obtained, the decocted refined honey is poured into the medicinal powder, the medicinal powder is stirred rapidly by a stirrer while the honey is poured, and the stirring is continued for 10 to 20 minutes when the dry medicinal powder is basically not seen; and then the raw materials are kneaded into a thin strip shape, the strip shape is cut into thin sections, the pills are prepared, 0.25 to 0.35 g of thin pills are prepared in the pill, and the thin pills are subpackaged according to 12 g of each small bag, so that the honeyed pill product comprehensive pregnancy promoting medicine suitable for symptoms of deficiency of qi and blood, damp and hot in lower jiao, deficiency of kidney qi, cold evil squat and the like is obtained.

[ usage amount ]: the preparation is taken 4 times a day, 10g each time, half an hour before and after a meal, and half a month is a treatment course.

[ accommodation range ]: various infertility symptoms.

Example 3.

A Chinese medicinal oral liquid for treating infertility, which is mainly due to deficiency of qi and blood, is prepared by adding 5kg of radix Angelicae sinensis on the basis of example 2. Taking 50kg of codonopsis pilosula, 30kg of cistanche, 50kg of sargentgloryvine stem, 35kg of angelica, 10kg of ligusticum wallichii, 20kg of radix paeoniae alba, 30kg of radix rehmanniae preparata, 50kg of cortex moutan, 10kg of cassia twig and 10kg of medicated leaven; adding clean water 10 times of the total weight of the raw materials, namely adding 2950kg of clean water, firstly soaking for 40 minutes, then boiling with strong fire, stewing for 90-100 minutes with slow fire, and filtering to obtain a solution; then putting the dregs into 8 times of 2360kg of clear water, boiling with big fire, stewing with small fire for 55-65 minutes, filtering and taking liquid; then putting the dregs into 6 times of 1770kg of clear water, boiling with strong fire, stewing with slow fire for 30-35 minutes, filtering and taking the liquid; and combining the three decoctions, filtering to obtain a filtrate, concentrating the filtrate to a weight equal to the total weight of the raw material medicines, namely 295kg, and then containing the concentrated solution according to 100ml per vial to obtain the qi-blood deficiency type pregnancy-promoting medicine of the oral liquid product.

[ usage amount ]: the preparation is taken 4 times a day, 100ml each time, half an hour before and after a meal, and half a month is a treatment course.

[ accommodation range ]: various infertility symptoms.

Example 4.

A traditional Chinese medicine composition oral liquid for treating infertility, which emphasizes damp-heat symptom of lower jiao, is prepared, and the cortex moutan is added by 8kg on the basis of the embodiment 2. Taking 50kg of codonopsis pilosula, 30kg of cistanche, 50kg of sargentgloryvine stem, 30kg of angelica, 10kg of ligusticum wallichii, 20kg of radix paeoniae alba, 30kg of radix rehmanniae preparata, 58kg of cortex moutan, 10kg of cassia twig and 10kg of medicated leaven; adding clean water 10 times of the total weight of the raw materials, namely adding 2980kg of clean water, firstly soaking for 40 minutes, then boiling with strong fire, stewing for 90-100 minutes with slow fire, and filtering to obtain a solution; then putting the dregs into 8 times of clean water, namely 2384kg, stewing the dregs for 55-65 minutes by small fire after boiling by big fire, and filtering the decoction to obtain liquid; then putting the dregs into 6 times of 1788kg of clear water, boiling with strong fire, stewing with slow fire for 30-35 minutes, filtering and taking the liquid; combining the three decoctions, filtering to obtain a filtrate, concentrating the filtrate to a weight equal to the total weight of the raw material medicines, namely 298kg, and then containing the concentrated solution according to 100ml per vial to obtain the wet-heat type pregnancy-promoting medicine of the oral liquid product.

[ accommodation range ]: various infertility symptoms.

Example 5.

The traditional Chinese medicine composition oral liquid for treating infertility, which emphasizes on the symptoms of kidney qi deficiency and cold evil face squat, is prepared, and the cistanche is increased by 5kg on the basis of the embodiment 2. Taking 50kg of codonopsis pilosula, 35kg of cistanche, 50kg of sargentgloryvine stem, 30kg of angelica, 10kg of ligusticum wallichii, 20kg of radix paeoniae alba, 30kg of radix rehmanniae preparata, 50kg of cortex moutan, 10kg of cassia twig and 10kg of medicated leaven; adding clean water 10 times of the total weight of the raw materials, namely adding 2950kg of clean water, firstly soaking for 40 minutes, then boiling with strong fire, stewing for 90-100 minutes with slow fire, and filtering to obtain a solution; then putting the dregs into 8 times of 2360kg of clear water, boiling with big fire, stewing with small fire for 55-65 minutes, filtering and taking liquid; then putting the dregs into 6 times of 1770kg of clear water, boiling with strong fire, stewing with slow fire for 30-35 minutes, filtering and taking the liquid; and combining the three decoctions, filtering, concentrating to 295kg of raw medicinal materials, and then containing 100ml of concentrated solution in each bottle to obtain the deficiency-cold type pregnancy-promoting medicine.

[ accommodation range ]: various infertility symptoms.

Example 6.

Preparing a traditional Chinese medicine composition powder electuary for treating infertility, taking 70kg of codonopsis pilosula, 50kg of cistanche, 70kg of sargentgloryvine stem, 50kg of angelica, 20kg of ligusticum wallichii, 30kg of radix paeoniae alba, 45kg of radix rehmanniae preparata, 80kg of cortex moutan, 20kg of cassia twig and 15kg of medicated leaven; adding 10 times of 4500kg of clear water, soaking for 50 min, boiling with strong fire, stewing with slow fire for 90-100 min, and filtering to obtain filtrate; then putting the medicine residues into 8 times of 3600kg of clear water, stewing the medicine residues for 55-65 minutes by small fire after boiling by big fire, and filtering to obtain liquid; then putting the dregs into 6 times of clean water (2700 kg), stewing the dregs for 30-35 minutes with slow fire after boiling with big fire, and filtering to obtain liquid; and merging the decoctions for three times, concentrating, drying, crushing, sieving by a 100-mesh sieve to obtain powder, and subpackaging the powder according to 6 g per small bag to obtain the universal pregnancy promoting powder.

[ usage amount ]: the medicine is taken 4 times a day, 6 g each time, is infused with boiled water and is taken with warm water half an hour before and after a meal, and half a month is a treatment course.

[ accommodation range ]: various infertility symptoms.

And (5) observing clinical curative effect.

First, case selection.

Selecting couples 122 of patients with infertility, age 26-45 years old for male and 24-40 years old for female, who are diagnosed in Minkang clinics of Qianjiang district of Chongqing from 1 month to 2018 month in 2015.

And II, diagnosis basis of infertility.

The diagnosis was made according to the "gynaecology" (textbook of higher medical colleges and universities, nationwide).

The non-pregnant person who has normal sexual life and is not subjected to contraception for 1 year is called infertility.

And the non-pregnant woman is called as primary infertility disease after the marriage in 1 year without contraception.

And the infertile people who have been pregnant and then have no contraception for 1 year are called secondary infertility.

Thirdly, the evaluation standard of the curative effect.

The preparation method comprises the following steps of clinical cure: correcting the primary disease, and delivering from normal pregnancy to full term.

The medicine is used for treating: the patients are not yet pregnant after the treatment of the medicines.

Fourthly, the using method comprises the following steps: the medicine is taken orally, and the couple and the medicine are taken simultaneously for 4 times per day, warm taking is carried out, and a treatment course is half a month. The medicine is taken in the first half month and is stopped in the second half month, and all patients are treated for 2-8 courses of treatment. The 122 pairs of couples have infertility, male diseases and female diseases, but even if the male or female has the disease independently, the other should be matched, so that both the male and female are required to be treated and taken at the same time during treatment; the medicine is taken according to corresponding diseases when the patient has infertility, and the medicine is taken according to comprehensive diseases when the patient does not have infertility; corresponding medicines are taken at the early stage corresponding to the prominent symptoms, and the comprehensive pregnancy promoting medicines are taken after a period of time.

The 122 couples of 244 patients simultaneously show comprehensive symptoms of deficiency of qi and blood, damp-heat in lower-jiao, deficiency of kidney qi, cold evil squat and the like, and a small number (8 patients) of 152 patients without infertility take the honeyed pill comprehensive pregnancy promoting medicine produced in the example 2. Of these patients, 18 persons showing more prominent symptoms of deficiency of qi and blood took the oral liquid qi-blood deficient type progestational agent produced in example 3. Among these patients, 30 persons with more prominent symptoms of damp-heat in the lower-jiao took the oral liquid damp-heat type progestational drug produced in example 4. Of these patients, 44 people who had prominent symptoms of kidney qi deficiency and cold pathogen convulsive squat were administered the oral liquid pregnancy-promoting drug of deficiency-cold type produced in example 5. After 2-3 courses of treatment, the honeyed pills are taken for comprehensive pregnancy promoting medicine.

And fifthly, attention points.

The same room is forbidden during the first half month of medicine taking, so as to avoid fatigue. Uncooked, cold, greasy and spicy food is prohibited during administration, and the medicine can be stopped after pregnancy.

Sixthly, treatment results.

After 2-8 months of medication treatment, 149 of 152 people suffering from comprehensive symptoms are cured among 122 couples, 16 of 18 people mainly suffering from qi-blood deficiency symptoms are cured, 27 of 30 people mainly suffering from the following symptoms of dampness and heat in the lower jiao are cured, and 39 of 44 people mainly suffering from kidney qi deficiency and cold evil according to symptoms are cured; of these patients, 112 couples were successfully pregnant within 8 months, and 107 couples delivered at term, with a successful cure rate of 87.7%. See table below.

And seventhly, a conclusion is drawn.

The invention has obvious treatment effect on infertility, has no toxic or side effect during treatment, is convenient to take, has the effective rate of 91.8 percent and the cure rate of 87.70 percent, and is a preferred medicine for patients with infertility.

Eight, typical cases.

The patient is a couple, a male and a female, the male is a couple, the female is a 28-year old, both are office-enterprise workers, the office-enterprise workers often overtime, the living life is less regular, the marriage is carried out for 5 years, no contraceptive measures are taken after the marriage, the patient is not pregnant, a plurality of doctors and doctors are available, and the doctor is introduced by friends to visit the department: often complaining of lumbago is easy to fatigue, particularly obvious in fatigue and rainy days, moist scrotum, yellow urine, pale tongue, white greasy tongue coating and deep pulse, and the examination and prompt in the hospital are as follows: curing certain lumbar muscle strain, prostatitis and low sperm motility, and diagnosing: kidney yang deficiency, damp-heat in the lower-jiao; the patient is easy to feel dizzy, cool limbs, poor sleep, easy excited or low mood, delayed menstruation, small amount, light color, waist and abdominal pain in menstrual period, sleepiness and weakness, and the previous examination: pelvic effusion, adnexitis, and mild anemia. Deep and thready pulse, pale tongue with white coating. And (3) diagnosis: deficiency of both qi and blood. After taking one of the damp-heat type pregnancy promoting medicine oral liquid products and one of the qi and blood deficiency type pregnancy promoting medicine oral liquid products, after taking 2 courses, the symptoms of lumbago in one of the great vessels basically disappear, the occasional feelings are tired, the urine is clear, the dizziness in one of the old vessels disappears, the limbs are warm, the mood is pleasant, the menstruation is basically recovered to be normal, and the symptoms of lumbago and abdominal pain in the menstrual period disappear. Then, the couple takes the Chinese medicinal composition honeyed pill product to realize successful pregnancy after 5 courses of treatment, stops taking the medicine, and gives birth to 1 male baby in term.

The patient declines a couple, male, 28 years old, his wife opens a certain book, 26 years old, both couples are unit workers, marriage for 2 years, contraceptive measures are not taken, no pregnancy is performed all the time, more diagnosis and treatment are performed within 1 year before our visit, decline a certain complaint work is easy, but sitting for a long time, lack of exercise, frequent deep yellow urine, and defecation is accompanied with burning sensation, no obvious abnormality is seen in hospital examination, the pulse is slippery, the tongue is red and greasy, and diagnosis: damp-heat in the lower energizer. Zhang Zhi Yue you are bad in constitution, especially afraid of cold, gallbladder is small, nightmare is caused, gastrointestinal tract function is bad in nearly two years, diarrhea can happen if diet is careless, there is a history of unexpected pregnancy before marriage, pregnancy is terminated manually for various reasons, thereafter pregnancy is not performed again, and hospital examination suggests: pelvic effusion of 3.6cm, left fallopian tube blockage, and low hormone level. The pulse is weak, the tongue is pale with white coating. And (3) diagnosis: deficiency of both qi and blood, deficiency of both the heart and kidney. The oral liquid of the damp-heat type pregnancy promoting drug is taken for a patient, and the oral liquid of the qi-blood deficiency type pregnancy promoting drug is taken for a patient, after 1 treatment course, the patient feels a little cold, the nightmare symptom disappears after the patient feels a little cold, the appetite is enhanced, and the diarrhea symptom does not appear after the patient takes the oral liquid of the damp-heat type pregnancy promoting drug; then, the couple takes the Chinese medicinal composition honeyed pill product to synthesize the pregnancy promoting medicine for 2 courses of treatment at the same time, so that the pregnancy is successful, the next child is born in term, and the mother and the children are safe.

The patient is a couple, a lie, a man, a 42 year old, a wife, a grandfather, a 38 year old, a lie is an individual family, a wife works in a unit, a woman is born, the 11 year old, and the birth is intentionally regenerated and born again due to the adjustment of birth control policy, but the patient is not as desired. Li's complaints are caused by business, and the peaceful nature is tired, so it often feels poor energy, cold pain of waist and knees, occasionally feels dizziness and tinnitus, the pulse is deep and thin, the tongue coating is thin and white, and the diagnosis: deficiency of liver and kidney. Often sit for a long time due to work, lack of exercise, often neck and waist stiffness and pain, and often affect urinary tract infection, irregular menstruation, black color, less amount, yellow and thick leucorrhea with peculiar smell, deep and thready pulse, red tongue and white fur, diagnosis: kidney yin deficiency, dampness-heat in the lower energizer. When a certain plum is taken with the deficiency-cold type pregnancy promoting oral liquid of the traditional Chinese medicine composition, and a certain sun is taken with the damp-heat type pregnancy promoting oral liquid of the traditional Chinese medicine composition, after taking for 3 courses of treatment, the plum feels vigorous, and symptoms of cold pain in waist and knees, dizziness and tinnitus disappear. Stiffness and pain of the neck and waist of Sunzhi are obviously improved, the menstrual regularity, color, quality and quantity are normal, and the leucorrhea is normal. Then the integrated pregnancy promoting medicinal honey pill product of the traditional Chinese medicine composition is continuously taken by the couples, successful pregnancy can be achieved after the couples continuously take the medicinal honey pill product for 3 courses of treatment, the women and the children can give birth in full term, and the mothers and the children are safe.

The male couple, male, female, male, female, male, female: L5-S1 herniated disc (central type), no obvious abnormality is seen, the pulse is deep and thin, the tongue is pale and the tongue fur is white, and diagnosis is as follows: liver and kidney deficiency and impaired meridians. Zhang a complaint is limited by rural sanitary conditions, is lack of sexual hygiene, frequent micturition, urgent micturition and odynuria, and is treated by purchasing amoxicillin capsules orally, and other medicines basically have no discomfort. And (3) diagnosis: damp-heat in the lower energizer. When a certain populus is taken with the deficiency-cold type pregnancy promoting oral liquid of the traditional Chinese medicine composition, and a certain populus is simultaneously taken with the damp-heat type pregnancy promoting oral liquid, after 3 courses of treatment, the lumbago symptom of the populus disappears, does not relapse, obviously enhances the sexual desire compared with that before the medicine is taken, and improves the premature ejaculation symptom; the symptom of Zhangzhi urinary tract infection disappears and does not recur. Then the integrated pregnancy promoting medicinal honey pill product of the traditional Chinese medicine composition is continuously taken by the couples, the couples take the medicinal honey pill product for 3 courses of treatment, the pregnancy is successfully performed, the next child is born in term, and the mother and the children are safe.

Patients are married for nearly 10 years, pregnant for 2 times in two years before marrying, aborted in the middle of pregnancy, and then not pregnant, invalid for medical treatment in four places, tired of debt, fatigued body and mind, and presented with a trial of mind and consultation before the mood. The rest complaints are caused by no fixed work, the life is irregular, and the rest complaints are often played after being decocted all the time, the lumbosacral part is often felt to be sour, swollen and uncomfortable, the urine is yellow, the eyes are dry and astringent, the perineum is wet, the palms and soles are easy to sweat, and the prior examination has no obvious abnormality, the pulse is deep and weak, the tongue is red, the tongue has yellow coating, and the diagnosis is carried out: deficiency of liver-yin and kidney-yin. Thank for certain complaints, poor plain constitution, parturient after 4 and 5 months of pregnancy, poor home situation, incomplete repair and rehabilitation after parturition, dizziness, cold limbs, lassitude and weakness, appetite reduction, low mood, delayed menstruation, little amount and light color, lingering for 10 days, thready and weak pulse, white and greasy tongue coating, diagnosis: deficiency of both qi and blood, deficiency of both the heart and kidney. After taking the traditional Chinese medicine composition for 5 treatment courses, the rest people suffer from soreness and distension of lumbosacral parts, dry eyes, moist perineum, easy cold sweat of palms and soles, good mental state, greatly increased diet, disappearance of dizziness symptoms, warm limbs and normal menstruation. Then, the integrated pregnancy promoting medicinal honey pill product of the traditional Chinese medicine composition is continuously taken by couples, and the patients are continuously taken for 3 courses of treatment, so that the patients are successfully pregnant, delivered in full term and safe for mothers and women.

Claims

1. A traditional Chinese medicine composition for treating infertility is characterized by being prepared from the following raw material medicines: radix Codonopsis, Cistanchis herba, caulis Sargentodoxae, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae alba, radix rehmanniae Preparata, cortex moutan, ramulus Cinnamomi, and Massa Medicata Fermentata; the weight ratio of the raw material medicines is as follows: 30-70 parts of codonopsis pilosula, 15-50 parts of cistanche, 30-70 parts of sargentgloryvine stem, 20-50 parts of angelica, 5-20 parts of ligusticum wallichii, 10-30 parts of radix paeoniae alba, 15-45 parts of radix rehmanniae preparata, 30-80 parts of cortex moutan, 5-20 parts of cassia twig and 5-15 parts of medicated leaven.

2. The Chinese medicinal composition for treating infertility according to claim 1, wherein:

the weight ratio of the raw material medicines is as follows: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the compound progestational drug is defined;

the weight ratio of the raw material medicines is as follows: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 35 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the medicines are defined as qi and blood deficiency type pregnancy-promoting medicines;

the weight ratio of the raw material medicines is as follows: 50 parts of codonopsis pilosula, 30 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 58 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the medicine is defined as a damp-heat type pregnancy-promoting medicine;

the weight ratio of the raw material medicines is as follows: 50 parts of codonopsis pilosula, 35 parts of cistanche, 50 parts of sargentgloryvine stem, 30 parts of angelica, 10 parts of ligusticum wallichii, 20 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 50 parts of cortex moutan, 10 parts of cassia twig and 10 parts of medicated leaven, and the composition is defined as a pregnancy-promoting medicine of deficiency-cold type.

3. The Chinese medicinal composition for treating infertility according to claim 2, wherein the product form of the Chinese medicinal composition is one of the following dosage forms: oral liquid, granule, tablet, capsule, and pill.

4. The Chinese medicinal composition for treating infertility according to claim 3, wherein the preparation method of the oral liquid is as follows: weighing the raw material medicaments according to the proportion, adding clear water which is 10 times of the total weight of the raw material medicaments, firstly soaking for 30-50 minutes, then boiling with strong fire, then slightly boiling with small fire for 90-100 minutes, and then filtering to obtain liquid; then putting the dregs into clear water with the weight 8 times of the total weight of the raw materials, boiling with big fire, decocting with small fire for 55-65 minutes, and filtering to obtain a solution; then putting the dregs into clear water with 6 times of the total weight of the raw materials, boiling with big fire, decocting with small fire for 30-35 minutes, and filtering to obtain a solution; mixing the three decoctions, filtering, concentrating to weight equal to the total weight of the raw materials, and packaging with 100ml per vial.