CN100475253C - A medicine for treating infertility, irregular menstruation, dysmenorrhea, endocrine disorders and osteoporosis - Google Patents
A medicine for treating infertility, irregular menstruation, dysmenorrhea, endocrine disorders and osteoporosis Download PDFInfo
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- CN100475253C CN100475253C CNB200610041815XA CN200610041815A CN100475253C CN 100475253 C CN100475253 C CN 100475253C CN B200610041815X A CNB200610041815X A CN B200610041815XA CN 200610041815 A CN200610041815 A CN 200610041815A CN 100475253 C CN100475253 C CN 100475253C
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Abstract
The invention provides a medicament for treating barrenness, abnormal menstruation, dysmenorrhea, endocrine dyscrasia and osteoporosis, which comprises the following raw materials (by weight portions): Chinese angelica root 80-120, doddor seed 80-120, wolfberry fruit 80-120, fleece-flower root 80-120, ligustrum japonicum 70-100, Siberian solomonseal rhizome 70-100, astragalus root 55-85, soybean isoflavones 10-30, VE 10-20, and Zn 3-10.
Description
Technical field
The present invention relates to a kind of treatment infertility, menoxenia, dysmenorrhea, endocrine disturbance and osteoporotic medicine.
Background technology
Menoxenia occupies first of gynecological's warp, band, tire, the product four big diseases, is commonly encountered diseases, the frequently-occurring disease of gynecological.Infertility also is one of gynecological clinic commonly encountered diseases, and sickness rate reaches 5%～15%.This sick cause of disease, pathogenesis are a lot, and conclusion is got up, and nothing more than congenital defect, lacks of proper care after one's birth.Relate to the stagnation of QI, the functional disorder of internal organs such as the cause of disease such as cold-damp and liver,spleen,kidney.And be modal pathogenesis with blood stasis, blood deficiency, deficiency of the liver and kindey.
Chinese medicine is to the understanding of disease etiology and pathogenesis such as infertility, menoxenia, dysmenorrhea, conclusion is got up, nothing more than congenital defect, lack of proper care after one's birth, relate to the malfunction of internal organs such as the causes of disease such as the stagnation of QI, cold-damp, fatigue and liver,spleen,kidney, and with the blood stasis blood deficiency, deficiency of the liver and kindey is modal pathogenesis.Kidney storing essence is basis of reproduction.So, liver controlling conveyance and dispersion and store blood, with menstruation normally whether, closely related.Deficiency of liver-blood, then the menstruation source is limited, and menoxenia, amenorrhea take place easily.If because of congenital deficiency of kidney-QI, the day after tomorrow sexual strain, or after the serious disease prolonged illness, or essence and blood is short, deficiency of the liver and kindey, or feelings will is not smooth, causes the liver failing to maintain the normal flow of QI, stagnation of QI-blood, influence is dashed and is appointed the blood of uterus capable, all can cause infertility, menoxenia, dysmenorrhea.The deficiency of YIN, blood deficiency all can cause interior the giving birth to of deficiency-heat and see all diseases of vexed hot-tempered heat.And modern medicine thinks that infertility, menoxenia, these diseases of dysmenorrhea are relevant with the endocrine disturbance, as " practical combination of Chinese and Western medicine diagnoses and treatment " what is called: " the inside and outside many factors of body are as cataclysm, fatigue, malnutrition or metabolism disorder of spiritual hypertonicity, fear, natural environment and climate or the like.These factors are all disturbed the mutual adjusting and the restriction mechanism of hypothalamus--hypophysis---ovary by corticocerebral neurotransmitter, so that lose normally cyclically-varying clocklike, outstanding behaviours is at ovarian dysfunction, sex hormones secretion amount not normal, influence the target organ endometrium, thereby make menoxenia." " the dysmenorrhea pilosity is born in ovulatory cycle, can treat dysmenorrhea because of oral contraceptive suppresses ovulation again, illustrates that all dysmenorrhea is relevant with the ovary endocrine." again from clinical, women's lusterless complexion, all diseases of vexed hot-tempered heat often occur simultaneously with infertility, menoxenia, amenorrhea.This is because the blood stasis blood deficiency, deficiency of the liver and kindey, can not Rong Run on the essence and blood in face, can not travel the uterus under then.In addition, deficiency of the liver and kindey is more common in the hepatic and renal YIN deficiency, deficiency of YIN bringing about interior heat, and heat is disturbed the mind, so intentionally irritated hot all diseases.
Summary of the invention
The purpose of this invention is to provide a kind ofly treat that blood stasis, blood deficiency, deficiency of the liver and kindey are barrenness caused, menoxenia, dysmenorrhea, endocrine disturbance and osteoporosis and the medicine of the lusterless complexion that occurs, all diseases of vexed hot-tempered heat, this curative effect of medication height, take a kind of medicine and can treat several diseases, treatment face width, taking convenience simultaneously.
Medicine of the present invention is made by the raw material medicaments in part by weight of following component:
Radix Angelicae Sinensis 80-120 Semen Cuscutae 80-120 Fructus Lycii 80-120
Radix Polygoni Multiflori (system) 80-120 Fructus Ligustri Lucidi 70-100 Rhizoma Polygonati 70-100
Radix Astragali 55-85 soybean isoflavone 10-30 V
E10-20 Zn3-10.
Preparation method: eight flavors in the prescription, Radix Angelicae Sinensis, Radix Polygoni Multiflori (system), the Radix Astragali, drying is pulverized, and crosses 100 mesh sieves, and fine powder is standby; Coarse powder and Semen Cuscutae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Fructus Lycii four flavors decoct with water three times by decocting method, and 1.5 hours for the first time, second and third time each 1 hour filtered, merging filtrate is condensed into thick paste, mixes 70～75 ℃ of dryings with above-mentioned fine powder and soybean isoflavone, pulverize, mixing, packing, promptly.
From the description of background technology, treat the key of infertility, menoxenia, dysmenorrhea as can be seen, will catch main pathogenesis exactly---blood stasis blood deficiency, deficiency of the liver and kindey.
We are just according to main the pathogenesis---blood stasis blood deficiency of infertility, menoxenia, dysmenorrhea, deficiency of the liver and kindey, and with nourishing blood and promoting blood circulation, nourishing the liver and kidney is a principle of treatment, so Radix Angelicae Sinensis nourishing blood and promoting blood circulation, Semen Cuscutae nourishing the liver and kidney; Be monarch drug.Soybean isoflavone helps the Radix Angelicae Sinensis nourishing blood and promoting blood circulation, and Radix Polygoni Multiflori, Fructus Lycii, Rhizoma Polygonati, Fructus Ligustri Lucidi help the Semen Cuscutae nourishing the liver and kidney to be ministerial drug altogether, and Radix Astragali benefiting qi and nourishing blood, benefiting QI for activating blood circulation are assistant.Play nourishing blood and promoting blood circulation altogether, the merit of nourishing the liver and kidney.Radix Angelicae Sinensis, sweet in the mouth, suffering, hardship, warm in nature.Return liver, the heart, spleen channel.The function blood-supplementing blood-nourishing is invigorated blood circulation, menstruction regulating and pain relieving.Be all cards of blood deficiency, menoxenia, amenorrhea, the good medicine of dysmenorrhea.
Modern pharmacological research proves, the Radix Angelicae Sinensis infusion orally can significantly be facilitated hemoglobin and erythrocytic generation for mice, platelet aggregation is had the obvious suppression effect, Radix Angelicae Sinensis is relevant with the functional status in uterus to the effect in uterus, when intrauterine does not pressurize, Radix Angelicae Sinensis slightly suppresses uterine contraction, uterus muscle relaxes, and blood flow is unimpeded, local nutrition improvement; During the intrauterine pressurization, then make uterine contraction by arythmia, and the rhythm and pace of moving things is slack-off, this moment, there was the abundant time of having a rest in the uterus, and contractility increases.Therefore, we are with when being classified as first of the monarch drug; Semen Cuscutae, acrid in the mouth, sweet, property is flat.Return the liver,kidney,spleen warp.The function the kidney invigorating and essence nourishing, Gu nourishing the liver to improve visual acuity is tire antidiarrheal." book on Chinese herbal medicine converges and says " utmost point says that this medicine power is comprehensive, and meaning: " medicine of warming the spleen stomach also for Semen Cuscutae, the kidney invigorating nourishing the liver.But mend and not high, temperature and not dry is so go into kidney channel.Void can be mended, in fact can in order to, cold can temperature, heat can be cool, wet can dryly, dry can the profit ", " control woman's ache of the spinal column, the normal pain of lower abdomen, or deficiency-cold of uterus, driping leukorrhea, or diet reduces, loose stool is the card of all male woman's foot three deficiency of YIN." name side's SHOUTAI WAN in " Records of Tradition Chinese and Western Medicine in Combination " both had been monarch drug with the Semen Cuscutae.Modern pharmacology experimental results show that: female mice is irritated the mixed liquor 0.5g that stomach is given the immersion of Semen Cuscutae alcohol, and every day 1 time, successive administration 4d can significantly increase uterus weight, promotes the vaginal epithelial cell keratinization, so; Has estrogenic activity.Female rats gavages decoct 10kg/kg, serve on 5d every day 2 times, and antepituitary, ovary and uterus weight are increased ... ovary chorionic gonadotropin/interstitialcellstimulating hormone (ICSH) (HCG/LH) receptor-specific adhesion and HCG/LC acceptor number increase; Make the LH secretory reaction raising of the hypophysis of removal ovary rat to injection luteinizing hormone releasing hormone (LRH),--hypophysis---gonad (ovary) s function has excitation to the prompting Semen Cuscutae to hypothalamus.So we to be invigorating blood circulation and invigorating the liver and kidney is laid equal stress on, with Semen Cuscutae and Radix Angelicae Sinensis respectively when simultaneously, all as monarch drug.Soybean isoflavone is compositions such as daiazi contained in the Semen sojae atricolor, genistin.The Semen sojae atricolor sweet in the mouth is flat, returns the spleen kidney channel.The function activating blood and promoting diuresis, the detoxifcation of dispeling the wind, tonifying speen and tonifying kidney.Modern pharmacological research proves that the big legumin of contained trace and genistein all have estrogen-like effects in the Semen sojae atricolor.Therefore, our selected soybean isoflavone helps the Radix Angelicae Sinensis nourishing blood and promoting blood circulation.Radix Polygoni Multiflori, nourishing the blood and yin is taken a tonic or nourishing food to build up one's health Liver and kidney." Japan hanako materia medica " meaning: " clothes have made us son for a long time." the Li Shizhen (1518-1593 A.D.) meaning: " the kidney master closes the Tibetan, liver controlling conveyance and dispersion.This thing temperature, bitter and puckery flavor.Bitter the kidney invigorating, the temperature compensation liver puckeryly can be restrained vital essence.The liver benefiting so can nourish blood, the controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black moustache is sent out, and is tonic medicine.Cold not dry, merit is on Radix Rehmanniae, all medicines of Radix Asparagi." Fructus Lycii, sweet in the mouth is flat, function the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Rhizoma Polygonati, the moon of kind spleen reinforcing kidney.Fructus Ligustri Lucidi, the moon of kind invigorating the liver and kidney and clearind deficient heat with helping the Semen Cuscutae nourishing the liver and kidney, is ministerial drug altogether with the soybean isoflavone that helps the Radix Angelicae Sinensis nourishing blood and promoting blood circulation is assistant with Radix Astragali benefiting qi and nourishing blood, benefiting QI for activating blood circulation again, and it is capable to get the capable then blood of gas, and QI invigorating is the meaning of hemopoietic.Full method degree is rigorous, and medication is concise, and the monarch and his subjects help mutually, and compatibility is proper, plays nourishing blood and promoting blood circulation altogether, the merit of nourishing the liver and kidney.
We through clinical practice, treat menoxenia 60 examples according to clinician's experience for many years, infertility 50 examples, and treatment perimenopausal syndrome 60 examples now are reported as follows:
Treatment menoxenia 60 routine visual reports
1 clinical data
Diagnostic criteria and Chinese medical discrimination that case is selected to meet menoxenia in " Chinese medicine clinical pharmacology " belong to blood deficiency, the deficiency of vital energy, suffer from a deficiency of the kidney, the Blood stasis person (has piece through the light red or dim purple of color, thin menses, tired, pale or sallow complexion, soreness of waist abdomen goes up painful, and has a dizzy spell, it is tired that body is stranded limb, thready pulse without strength etc.).Blood-deficiency type 14 examples, qi-deficiency type 10 examples, renal deficiency type 20 examples, Blood stasis person 16 examples.
2 Therapeutic Method
Ante cibum morning, the preceding warm water delivery service of sleeping evening.One time 4～6,2 times on the one.3 months is a course of treatment.
3 criterions of therapeutical effect
Cure: after the treatment, menstrual cycle through amount, recovers normal menstrual period, and 3 months menstruation cycles of drug withdrawal are all normal.Produce effects: after the treatment, menstrual cycle returned to 28 ± 7 days, and the excessive person of menstruation is minimizing 1/3 or be less than 100ml before amount is than treatment, return to menstrual period in 7 days, and other transference cure or alleviate, 3 months menstruation cycles of drug withdrawal are normal.Effectively: after the treatment, menstrual cycle, through amount, improve before the treatment menstrual period, and other symptom is also than alleviating before the treatment.Invalid: after the treatment, menstrual cycle through amount, does not have improvement menstrual period.
4 therapeutic outcomes
Cure 41 examples (68%), produce effects 15 examples (25%), invalid 4 examples (7%), total effective rate 93%.
Treatment woman's acyesis 50 routine visual reports
1 clinical data
The diagnostic criteria of " the 2 years unpregnancies or once had of marrying breed and continue and interval unpregnancy person more than 2 years " that 1.1 diagnostic criteria 50 examples meet all that Department of Medical Administration of national traditional chinese medical science administration in 1998 proposes, and the necessary routine examination of pressing infertility diagnosis, it is obstructed to get rid of bridegroom's or husband's side factor and wife's side uterus and fallopian tube.
1.2 among the physical data 50 routine patients, primary infertility 15 examples, secondary infertility 35 examples.Double disease: heat in blood infertility induced by dysmenorrhea 15 examples, heat in blood stasis of blood resistance blockage of menstruation 15 examples, heat in blood is also seen stagnation of QI due to depression of the liver 10 examples, kidney deficiency blood stasis type 10 examples.
2. Therapeutic Method
Ante cibum morning, the preceding warm water delivery service of sleeping evening.One time 4～6,2 times on the one.3 months is a course of treatment.
3. criterion of therapeutical effect
After treating (1～3 course of treatment), recovery from illness: give birth to or become pregnant; Produce effects: heat in blood is flat, and transference cure or obviously alleviate is not become pregnant but still have; Effectively: symptom alleviates before than treatment or improvement is arranged; Invalid: treatment back symptom does not have improvement.
4. therapeutic outcome
Cure 37 examples (74%), produce effects 8 examples (16%), effective 2 examples (4%), invalid 3 examples (6%), total effective rate 94%.
The 60 routine clinical observations of treatment perimenopausal syndrome
1. clinical data,
1.1 diagnostic criteria is according to " obstetrics and gynecology " the 5th edition.Meet Chinese medical discrimination.YIN-deficiency type: warm sweating, dizziness and tinnitus, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, insomnia and dreamful sleep, dryness of the mouth and throat or skin pruritus due to dryness, the confusion of the menstrual cycle, the few tongue of red tongue, thready and rapid pulse.Deficiency of yang type: dizziness and tinnitus, lumbago be as folding, cold cloudy bob of abdomen, coldness of the body with chills, frequent micturition or incontinence, profuse leukorrhea, menoxenia, lethargy, dim complexion, light red tongue, white, slippery and moist fur, deep-thready pulse and late.The associativity hormone determination, blood estradiol (E2) level is low, and follicule-stimulating hormone (FSH) raises, and interstitialcellstimulating hormone (ICSH) raises, and gets rid of gynecological's other diseases, cardiovascular and mental sickness, endocrine gland organic disease etc.
1.2 all patients derive from the hospital-based outpatient obstetrical clinic patient, complete 60 examples of including, age 40-55 year.
2. Therapeutic Method ante cibum early, the preceding warm water delivery service of sleeping evening.One time 4～6,2 times on the one.3 months is a course of treatment.
3. criterion of therapeutical effect adopts the change that observes the symptoms of improvement Kupperman point system.Symptom score is: hectic fever sweating 4 minutes, and indifferent each 2 minutes of scorching irritability, insomnia, libido, depressed, dizzy, headache, cardiopalmus are tired, urinary system infection, osteoarthrosis pain, skin pruritus each 1 minute.After every kind of symptom score multiply by coefficient 0-3 respectively by light and heavy degree, calculate total points, full marks are 54 minutes, and the state of an illness is heavy more, and integrated value is high more.
Clinical symptoms scoring curative effect judging standard
1. recovery from illness: the clinical symptoms scoring of treatment back reduces more than 90%, and the physico-chemical examination result recovers to be equivalent to the age bracket physiological level.
2. produce effects: the clinical symptoms scoring of treatment back reduces more than the 70-89%, and the physico-chemical examination result recovers to be equivalent to the age bracket physiological level.
3. effective: the clinical symptoms scoring of treatment back reduces more than the 30-69%, and the physico-chemical examination result recovers to be equivalent to the age bracket physiological level.
4. invalid: the clinical symptoms scoring of treatment back reduces more than＜30%, and the physico-chemical examination result does not all have improvement or worsens.
4. therapeutic outcome
After 60 routine perimenopausal syndrome patients took, symptom all had clear improvement, 10 examples of fully recovering (17%), produce effects 36 examples (60%), effective 14 examples (23%), invalid 0 example, total effective rate 100%.
Specific embodiment
Embodiment 1
Press column weight amount weighting raw materials (unit: restrain):
Radix Angelicae Sinensis 80 Semen Cuscutae 80 Fructus Lycii, 80 Radix Polygoni Multiflori (system) 80
Fructus Ligustri Lucidi 70 Rhizoma Polygonatis 70 Radixs Astragali 55 soybean isoflavone 10
V
E?10 Zn?3
Preparation method: eight flavors in the prescription, Radix Angelicae Sinensis, Radix Polygoni Multiflori (system), the Radix Astragali, drying is pulverized, and crosses 100 mesh sieves, and fine powder is standby; Coarse powder and Semen Cuscutae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Fructus Lycii four flavors decoct with water three times by decocting method, and 1.5 hours for the first time, second and third time each 1 hour filtered, merging filtrate is condensed into thick paste, mixes 70～75 ℃ of dryings with above-mentioned fine powder and soybean isoflavone, pulverize, mixing, packing, promptly.
Embodiment 2
Press column weight amount weighting raw materials (unit: kilogram):
Radix Angelicae Sinensis 90 Semen Cuscutae 90 Fructus Lycii, 90 Radix Polygoni Multiflori (system) 90
Fructus Ligustri Lucidi 75 Rhizoma Polygonatis 75 Radixs Astragali 60 soybean isoflavone 15
V
E?15 Zn?6
Preparation method: with embodiment 1.
Embodiment 3
Press column weight amount weighting raw materials (unit: restrain):
Radix Angelicae Sinensis 110 Semen Cuscutae 110 Fructus Lycii, 110 Radix Polygoni Multiflori (system) 110
Fructus Ligustri Lucidi 90 Rhizoma Polygonatis 90 Radixs Astragali 80 soybean isoflavone 20
V
E?10 Zn?8
Preparation method: with embodiment 1.
Embodiment 4
Press column weight amount weighting raw materials (unit: kilogram):
Radix Angelicae Sinensis 120 Semen Cuscutae 120 Fructus Lycii, 120 Radix Polygoni Multiflori (system) 120
Fructus Ligustri Lucidi 100 Rhizoma Polygonatis 100 Radixs Astragali 85 soybean isoflavone 30
V
E?20 Zn?10
Preparation method: with embodiment 1.
Embodiment 5
Press column weight amount weighting raw materials (unit: restrain):
Radix Angelicae Sinensis 100 Semen Cuscutae 100 Fructus Lycii, 100 Radix Polygoni Multiflori (system) 100
Fructus Ligustri Lucidi 82 Rhizoma Polygonatis 82 Radixs Astragali 66 soybean isoflavone 20
V
E?10 Zn?10
Preparation method: with embodiment 1.
Claims (1)
1, a kind of medicine for the treatment of infertility, menoxenia, dysmenorrhea and endocrine disturbance is characterized in that being made by following bulk drugs:
Radix Angelicae Sinensis 80-120 Semen Cuscutae 80-120 Fructus Lycii 80-120
Radix Polygoni Multiflori Preparata 80-120 Fructus Ligustri Lucidi 70-100 Rhizoma Polygonati 70-100
Radix Astragali 55-85 soybean isoflavone 10-30 V
E10-20 Zn 3-10.
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| CN1229130C (en) * | 2003-09-30 | 2005-11-30 | 武汉马应龙药业集团股份有限公司 | Medicine for treating kidney and spleen and preparing method thereof |
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| CN1229130C (en) * | 2003-09-30 | 2005-11-30 | 武汉马应龙药业集团股份有限公司 | Medicine for treating kidney and spleen and preparing method thereof |
Non-Patent Citations (4)
| Title |
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| 中医药治疗几种特殊月经病. 王长柏.当代健康报. 2004 |
| 中医药治疗几种特殊月经病. 王长柏.当代健康报. 2004 * |
| 浅谈血虚治肾和肾血虚证. 黄芝蓉.贵阳中医学院学报，第4期. 1986 |
| 浅谈血虚治肾和肾血虚证. 黄芝蓉.贵阳中医学院学报，第4期. 1986 * |
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