CN1229130C - Medicine for treating kidney and spleen and preparing method thereof - Google Patents
Medicine for treating kidney and spleen and preparing method thereof Download PDFInfo
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- CN1229130C CN1229130C CN 03134963 CN03134963A CN1229130C CN 1229130 C CN1229130 C CN 1229130C CN 03134963 CN03134963 CN 03134963 CN 03134963 A CN03134963 A CN 03134963A CN 1229130 C CN1229130 C CN 1229130C
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Abstract
The present invention discloses medicine for curing the kidneys and the spleens and a preparation method thereof. The medicine is prepared from astragalus root, fructus lycii, dodder seed, fleeceflower root, fructus, suberect spatholobus, angelica and tuckahoe. First, the stir frying with honey of the astragalus root is carried out in a honey fromation pan; secondly, the astragalus root processed through the stir frying with honey is jointly added to an extracting tank with the fructus lycii, the dodder seed, the fleeceflower root, the fructus, the suberect spatholobus, the angelica and the tuckahoe for carrying out extraction for two times; thirdly, alcohol is added to concentrated liquor for carrying out alcohol deposition, and after clear liquor is filtrated, concentration is carried out; fourthly, water is added to concentrated physic liquor which is processed through the alcohol deposition, uniform stirring, stewing, filtration, deposition removal and impurity removal are carried out, and the physic liquor is retained for reservation. Fifthly, honey is preprocessed; sixthly, the processed honey is added to the supernatant physic liquor which is processed through concentration and water deposition and is retained for reservation under the condition of stirring, and purified water is supplied for continuing stirring; seventhly, the physic liquor is heated until the physic liquor is boiled; eighthly, the refrigeration, the filtration and the filling of the physic liquor are carried out. The present invention has the advantages of simple technology, low cost, obvious curative effect and industrialized production suitability.
Description
Technical field
The present invention relates to a kind of insufficiency of the spleen weak medicine of kidney for the treatment of, specifically, this drug regimen can be used for person in middle and old age because of suffering from a deficiency of the kidney, insufficiency of the spleen due to disease such as soft, the inappetence of spiritlessness and weakness, the soreness of waist, insomnia and dreamful sleep, dizziness and blurred vision, the invention still further relates to the preparation method of this medicine.
Background technology
At present, the medicament categories that is used for the treatment of the insufficiency of the spleen weak oral liquid of kidney is a lot, and chemical synthetic drug is because the limitation of clinical efficacy and toxic and side effects is all unsatisfactory.Chinese medicine preparation is subjected to expert and patient's favorable comment owing to evident in efficacy and low toxic and side effects.Treat the insufficiency of the spleen weak oral liquid of kidney in the market and mainly contain medicines such as benefiting QI and nourishing blood oral liquid, compound black-bone chicken oral liquid, it is mainly with Radix Ginseng, Gallus Domesticus, benefiting QI and nourishing blood such as Radix Codonopsis are main, treat diseases such as gynaecological disease clinically curative effect is preferably all arranged, but its complicated process of preparation, the cost height, therapeutic domain is narrow and small.
Summary of the invention
The object of the present invention is to provide the insufficiency of the spleen weak medicine of a kind of treatment kidney, this compatibility of drugs is reasonable, and the system prescription just, and is evident in efficacy, effect is fast.
Another object of the present invention has provided a kind of preparation method of this medicine, and this method technology is simple, with low cost, energy consumption is low, is applicable to suitability for industrialized production.
The present invention can also make other dosage forms such as tablet, capsule preparations, pill.
For achieving the above object, the present invention realizes by following technical measures:
The Radix Astragali---QI invigorating invigorating middle warmer.It is weak to be used for the deficiency of vital energy, anorexia and loose stool.
Fructus Lycii---nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Semen Cuscutae---nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Be used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, the blurred vision ear toot, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Radix Polygoni Multiflori---invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Be used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void; Hyperlipidemia.
Fructus Ligustri Lucidi---nourishing the liver and kidney, black hair makes eye bright.Be used for vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Caulis Spatholobi---enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Angelicae Sinensis---enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Poria---promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia
Medicine of the present invention is formulated by following raw materials according, and consumption is a weight portion:
The Radix Astragali 75～115
Fructus Lycii 75～115
Semen Cuscutae 50～75
Radix Polygoni Multiflori 35～60
Fructus Ligustri Lucidi 35～60
Caulis Spatholobi 50～75
Radix Angelicae Sinensis 35～60
Poria 50～75
Mel 120～160
Ethyl hydroxybenzoate 0.1～0.9
Medicine of the present invention preferably formulated by following raw materials according, consumption is a weight portion:
The Radix Astragali 80～100
Fructus Lycii 80～100
Semen Cuscutae 55～70
Radix Polygoni Multiflori 40～55
Fructus Ligustri Lucidi 40～55
Caulis Spatholobi 55～70
Radix Angelicae Sinensis 40～55
Poria 55～70
Mel 130～150
Ethyl hydroxybenzoate 0.3～0.7
Among the present invention based on the Radix Astragali, Fructus Lycii QI invigorating, the kidney invigorating; Help the merit of invigorating the spleen and benefiting QI with the auxiliary Radix Astragali of Poria; With Semen Cuscutae, Radix Polygoni Multiflori, the auxiliary sub-invigorating the liver and kidney of Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) of Fructus Ligustri Lucidi, benefiting essence-blood; Radix Angelicae Sinensis is joined the Radix Astragali, contains the meaning of eastern permanent Chinese angelica blood supplementing; Fructus Ligustri Lucidi is joined the Radix Astragali, the meaning of residence " body resistance-strengthening Zhenqi " (regulating the immunologic function preparation); More help to foster the merit of blood with Caulis Spatholobi; Full side's invigorating the liver and kidney, beneficial marrow are weary to replenish old and feeble body.It is old and feeble main performance that modern medicine study, immunologic function go down.Improve the achievement in research of immunologic function in conjunction with modern about Chinese medicine, relatively poor because of old people's equilibrium between yin and yang ability, so we select the gentle product of flavour of a drug to consolidate, it is dry strong not ask taste to invest; All medicines share, and gather kidney and spleen invigorating altogether, the effect of benefiting QI and nourishing blood.This prescription is on the basis of record prescription in Compendium of Material Medica, at the insufficient shortcoming of original formulation QI invigorating, uses the Radix Astragali instead with QI invigorating; Going down at immunologic function is old and feeble main performance, adopts Fructus Ligustri Lucidi, Caulis Spatholobi to regulate immunologic function; Improve greatly through a large amount of experiment and clinical manifestation curative effects of the present invention, the scope of application increases.Great majority are to make solid preparation (as tablet, pill etc., because of its mouthfeel and absorb poorly, it is not too obvious that effect is taken in patient's reflection) on the market, and the present invention is the drug oral liquid preparation, and drug absorption is good, and drug effect is clear and definite.Invented the preparation method of this agent through years of researches.The present invention adopts the Chinese medicine extraction method, and drug effect absorbs fast.Manufacture method of the present invention, its step comprises: at first in the refined honey pot with Radix Astragali processed with honey; Next is that the Radix Astragali that processed with honey is good adds with Fructus Lycii, Semen Cuscutae, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Caulis Spatholobi, Radix Angelicae Sinensis, Poria and makes extracted twice in the extraction pot, merges Chinese medicine extraction liquid twice, concentrates the extracting solution of twice acquisition; The 3rd is to add ethanol 1000～1500ml in concentrated solution, carries out precipitate with ethanol, behind supernatant liquid filtering, concentrates; The 4th is to concentrate the water that adds concentrated liquid equimultiple behind the precipitate with ethanol in the good medicinal liquid behind precipitate with ethanol, stirs, and leaves standstill 24～48 hours, gets supernatant to filter, and removes precipitation and impurity, concentrates the supernatant behind the water precipitating, standby; The 5th is that 130～150Kg Mel is carried out pretreatment; The 6th is under condition of stirring, in the standby last clear liquid medicine behind the concentrated water precipitating of handling well of Mel adding, and mends purified water to cumulative volume, continues to stir; The 7th is that the 6th medicinal liquid that goes on foot is heated to boiling, and keeps 40～70 minutes; The 8th is to stop heating, and turn on agitator treats that medicinal liquid is cooled to 60～80 ℃, will slowly add in the medicinal liquid with the ethyl hydroxybenzoate behind the dissolve with ethanol, continues to stir, and treats that medicinal liquid is cooled to 30～45 ℃, filters, and fill promptly gets this product.
The present invention compares with existing Technology, has the following advantages and effect:
1, the present invention has adopted oral liquid, and mouthfeel is good, and drug absorption rate height is promoted curative effect of medication.
2, technology of the present invention is simply ripe, and cost is low, be suitable for suitability for industrialized production.
3, the present invention fills a prescription rationally.Drug distribution in the prescription is wide, aboundresources.
4, pharmacological research shows, the present invention has the effect of significant kidney and spleen invigorating, benefiting QI and nourishing blood.Pharmacodynamic experiment studies show that out the experimental animal models model is shown excellent curative.Show that in clinical a large amount of case treatments the present invention has good improvement effect to senile symptom, and it can also improve the sex hormone metabolism effect, reduce the effect of middle-aged and elderly people serum T ch, LDLC, reach function in delaying senility by kidney and spleen invigorating, benefiting QI and nourishing blood.The bound drug dynamics research shows, good absorbing of the present invention, and drug effect speed is fast, the bioavailability height, drug effect is clear and definite.
5, acute toxicity test shows, the present invention is nontoxic, safety.
The specific embodiment
Medicine embodiment consumption of the present invention following (weight portion):
A kind of preparation method for the treatment of the insufficiency of the spleen weak oral liquid of kidney, its step is as follows:
1, the processed with honey Radix Astragali
1), add Mel in the refined honey pot, slowly be heated to and boil, temperature is controlled at 90-110 ℃, crosses 50～120 mesh sieve scumming, impurity;
2), stir while tempering, refining is to twisting with the fingers toughness with hands, till two fingers do not have white silk separately the time, adds the dilution of 50～100L boiled water.
3), the Radix Astragali that takes by weighing formula ratio adds in the refined honey pot, stirs evenly down heating, temperature is controlled at 90-100 ℃, the limit heating edge is turned over and is copied, and copies to tack-free.
2, extract (decoct, concentrate, precipitate with ethanol, water precipitating)
1), decocts, concentrates
(1), the Radix Astragali, Fructus Lycii, Semen Cuscutae, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Caulis Spatholobi, Radix Angelicae Sinensis, Poria decoction pieces are added 5-15 times of water gaging, soaked 10～20 hours.Heating decocted 2～5 hours, filtered decoction liquor, and temperature is controlled at 90-110 ℃.
(2), the filtering residue that stays after filtering is added 8 times of water gagings again, continuation decoction 2～5 hours.Decoction liquor is filtered through filter for the second time, and with the decoction liquor merging first time, medicinal residues discard.
(3), twice decoction liquor is concentrated into about 1000～1200L.
2), precipitate with ethanol, concentrated
(1), in concentrated solution, adds 70～98% ethanol, about 1000～1500L; Make to contain alcohol amount and reach 60～80%, cooling was left standstill 24～48 hours.With supernatant liquid filtering, residue discards.
(2), the ethanol in the reclaim under reduced pressure supernatant, to there not being the alcohol flavor, obtain concentrated solution.
3), water precipitating, concentrated
Add 1～3 times of water gaging in the concentrated solution behind precipitate with ethanol, stir, cooling was left standstill 24～48 hours, filtered, and discarded precipitation.
3. preparation
1), Mel pretreatment
Mel is heated to boils 45 minutes, temperature is controlled at 90-110 ℃, crosses 50～120 mesh sieves, defoams, impurity.
2), the Mel handled well is added in the concentrated solution behind the water precipitating, add purified water, continue to be stirred to evenly to the medicinal liquid cumulative volume.
3), medicinal liquid is heated to boiling, temperature is controlled at 90-110 ℃.And keep seething with excitement 30～60 minutes.
4), stop heating, medicinal liquid is cooled to 60～80 ℃, stir down, slowly add in the medicinal liquid after ethyl hydroxybenzoate is dissolved with 2～5L ethanol (80～98%).
5), continue to stir, messenger drug liquid is cooled to 30～45 ℃, filters, fill promptly gets this product.
Claims (6)
1, the insufficiency of the spleen weak medicine of a kind of treatment kidney, it is made by following materials of weight proportions:
The Radix Astragali 75～115
Fructus Lycii 75～115
Semen Cuscutae 50～75
Radix Polygoni Multiflori 35～60
Fructus Ligustri Lucidi 35～60
Caulis Spatholobi 50～75
Radix Angelicae Sinensis 35～60
Poria 50～75
Mel 120～160
Ethyl hydroxybenzoate 0.1～0.9.
2, the insufficiency of the spleen weak medicine of a kind of treatment kidney according to claim 1 is characterized in that the weight proportion of each raw material is:
The Radix Astragali 80～100
Fructus Lycii 80～100
Semen Cuscutae 55～70
Radix Polygoni Multiflori 40～55
Fructus Ligustri Lucidi 40～55
Caulis Spatholobi 55～70
Radix Angelicae Sinensis 40～55
Poria 55～70
Mel 130～150
Ethyl hydroxybenzoate 0.3～0.7.
3, the insufficiency of the spleen weak medicine of a kind of treatment kidney according to claim 1 is characterized in that the weight proportion of each raw material is:
The Radix Astragali 98
Fructus Lycii 98
Semen Cuscutae 63
Radix Polygoni Multiflori 40
Fructus Ligustri Lucidi 40
Caulis Spatholobi 63
Radix Angelicae Sinensis 40
Poria 63
Mel 135
Ethyl hydroxybenzoate 0.4.
4, the insufficiency of the spleen weak medicine of a kind of treatment kidney according to claim 1 is characterized in that the weight proportion of each raw material is:
The Radix Astragali 85
Fructus Lycii 85
Semen Cuscutae 59
Radix Polygoni Multiflori 45
Fructus Ligustri Lucidi 45
Caulis Spatholobi 59
Radix Angelicae Sinensis 45
Poria 59
Mel 140
Ethyl hydroxybenzoate 0.5.
5, the insufficiency of the spleen weak medicine of a kind of treatment kidney according to claim 1 is characterized in that the weight proportion of each raw material is:
The Radix Astragali 91
Fructus Lycii 91
Semen Cuscutae 61
Radix Polygoni Multiflori 45
Fructus Ligustri Lucidi 45
Caulis Spatholobi 61
Radix Angelicae Sinensis 45
Poria 61
Mel 142
Ethyl hydroxybenzoate 0.5.
6, a kind of described a kind of preparation method for the treatment of the insufficiency of the spleen weak medicine of kidney of claim 1 that realizes comprises the following steps:
A, the processed with honey Radix Astragali at first are to add Mel in the refined honey pot, slowly are heated to and boil, and temperature is controlled at 90-110 ℃, cross 50～120 mesh sieve scumming, impurity; Next is to stir while tempering, and refining does not have till the white silk when two fingers separate to twisting with the fingers toughness with hands, adds the dilution of 50～100L boiled water; The 3rd is that the Radix Astragali that takes by weighing formula ratio adds in the refined honey pot, stirs evenly down heating, and temperature is controlled at 90-100 ℃, and the limit heating edge is turned over and copied, and copies to tack-free;
B, extraction at first are to decoct, concentrate, the one, the Radix Astragali, Fructus Lycii, Semen Cuscutae, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Caulis Spatholobi, Radix Angelicae Sinensis, Poria decoction pieces are added 5-15 times of water gaging, soaked 10～20 hours, heating decocted 2～5 hours, filtered decoction liquor, and temperature is controlled at 90-110 ℃; The 2nd, the filtering residue that stays after filtering is added 8 times of water gagings again, continue decoction 2～5 hours, decoction liquor is filtered through filter for the second time, and with the decoction liquor merging first time, medicinal residues discard; The 3rd, twice decoction liquor is concentrated into 1000～1200L; Next is precipitate with ethanol, concentrates, and the one, in concentrated solution, add 70～98% ethanol, 1000～1500L; Make to contain alcohol amount and reach 60～80%, cooling was left standstill 24～48 hours, and with supernatant liquid filtering, residue discards; The 2nd, the ethanol in the reclaim under reduced pressure supernatant to there not being the alcohol flavor, obtains concentrated solution; The 3rd is water precipitating, concentrated, adds 1～3 times of water gaging in the concentrated solution behind precipitate with ethanol, stirs, and cooling was left standstill 24～48 hours, filtered, and discarded precipitation;
C, preparation at first are the Mel pretreatment, Mel is heated to boils 45 minutes, and temperature is controlled at 90-110 ℃, cross 50～120 mesh sieves, defoam, impurity; Next be will handle well Mel add in the concentrated solution behind the water precipitating, add purified water to the medicinal liquid cumulative volume, continue to be stirred to evenly; The 3rd is that medicinal liquid is heated to boiling, and temperature is controlled at 90-110 ℃, and keeps boiling 30～60 minutes; The 4th is to stop heating, and medicinal liquid is cooled to 60～90 ℃, stir down, with ethyl hydroxybenzoate with 2～5L dissolve with ethanol after in the adding medicinal liquid; The 5th is to continue to stir, and messenger drug liquid is cooled to 30～45 ℃, filters, and fill promptly gets this product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03134963 CN1229130C (en) | 2003-09-30 | 2003-09-30 | Medicine for treating kidney and spleen and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03134963 CN1229130C (en) | 2003-09-30 | 2003-09-30 | Medicine for treating kidney and spleen and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1528369A CN1528369A (en) | 2004-09-15 |
| CN1229130C true CN1229130C (en) | 2005-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03134963 Expired - Lifetime CN1229130C (en) | 2003-09-30 | 2003-09-30 | Medicine for treating kidney and spleen and preparing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100475253C (en) * | 2006-02-22 | 2009-04-08 | 陈耀明 | Medicine for treating barrenness, irregular menses, painful menstruation, endocrine dyscrasia and osteoporosis |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330341C (en) * | 2005-11-11 | 2007-08-08 | 范中举 | Chinese medicine for essence nourishing, bady building and hearth protection |
| CN105535356A (en) * | 2014-11-03 | 2016-05-04 | 谢芳 | Traditional Chinese medicinal ointment and preparation method thereof |
-
2003
- 2003-09-30 CN CN 03134963 patent/CN1229130C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100475253C (en) * | 2006-02-22 | 2009-04-08 | 陈耀明 | Medicine for treating barrenness, irregular menses, painful menstruation, endocrine dyscrasia and osteoporosis |
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| Publication number | Publication date |
|---|---|
| CN1528369A (en) | 2004-09-15 |
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Owner name: MAYINGLONG PHARMACEUTICAL GROUP CO.,LTD. Free format text: FORMER NAME OR ADDRESS: WUHAN MAYINGLONG PHARMACEUTICAL GROUP CORP., LTD. |
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Assignee: XI'AN TAI CHI PHARMACEUTICAL Co.,Ltd. Assignor: MAYINGLONG PHARMACEUTICAL GROUP Co.,Ltd. Contract record no.: 2009610000020 Denomination of invention: Medicine for treating kidney and spleen and preparing method thereof Granted publication date: 20051130 License type: Exclusive License Open date: 20040915 Record date: 20091119 |
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