CN1047946C

CN1047946C - Preparation for treating senile diseases

Info

Publication number: CN1047946C
Application number: CN94107068A
Authority: CN
Inventors: 殷广全
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-06-17
Filing date: 1994-06-17
Publication date: 2000-01-05
Anticipated expiration: 2014-06-17
Also published as: CN1113778A

Abstract

The present invention relates to a preparation for treating senile diseases, which is prepared from ant having the functions for nourishing the kidney and liver, reinforcing the spleen, supplementing qi, nourishing blood, strengthening muscles and bones, expelling wind, dredging channels and regulating the immunity of human bodies as a main medicine. Natural animal and plant medicinal materials with the functions for nourishing the kidney, reinforcing the spleen, nourishing the heart to calm the mind and promoting blood circulation to remove blood stasis are added as auxiliary medicines, and a new 'like fermentation' technological process different from the traditional process is adopted. The preparation has the functions for replenishing essence, supplementing qi, removing food stagnancy, nourishing blood and promoting blood circulation, can effectively improve the function of the viscera and can increase immunity. The preparation has ideal effect for clinically preventing and treating senile diseases, such as hyperosteogeny, climacteric syndrome, embolism, hypertension, etc.

Description

Preparation for treating senile diseases

The invention belongs to the formulated Chinese medicine preparation of natural animal and plant medical material, be specifically related to a kind of senile disease Chinese medicine preparation.

Senile disease mainly comprises senile dementia, climacteric syndrome, hypertension, osteoporosis, hyperosteogeny, blood vessel inspection plug senile plaque, sexual disorder etc.All belong to increase along with the age, the decline of physical function, immunologic function weaken caused disease.Medical circle is consistent to be thought, old involution of thymus is old and feeble major reason.Thymus is the immune maincenter of human body, involution of thymus, and the human immunologic function is low, so that All kinds of diseases and ailments break out.Therefore; the traditional Chinese medical science adopts tonification or gets rid of illness; directly with the indirect old man's body constitution that strengthens; excite old man's body ﹠ mind vigor; the poised state of control agent internal and external environment; the infringement of elimination pathogenic factor, the above-mentioned various old illness of normal function, enhancing immunity, control of recovery human body, the purpose of delaying senility course.Chinese medicine decoction, though the doctor can be according to the dialectical plus-minus medication of the state of an illness, because of decocting complexity, dose is big, and very inconvenient, patient is difficult for adhering to.Existing Chinese patent medicine such as treasured three animal penes pill, select the formulated pill of kind of Chinese medicine surplus Radix Ginseng, Cornu Cervi Pantotrichum, Testis et penis callorhini, Penis et testis cervi, wide Penis et testis canitis, Hippocampus, Gecko, Cortex Cinnamomi, Lignum Aquilariae Resinatum, Radix Polygoni Multiflori, BAZAITIAN, Fructus Corni, the Radix Astragali, the Herba Epimedii etc. 40 for use, have that spermatogenesis is enriched blood, brain-strengthening is kept fit, replenishing QI to invigorate the spleen, nourishing blood to tranquillize the mind, focus on tonification and keep fit etc.Often the power of tonification is had a surplus, and it is low that power deficiency that gets rid of illness and old people digest and assimilate the receipts function, and mostly existing Chinese patent medicine is to use the traditional method of the not special processing of process to make, though so the old people takes the back certain effect is arranged, because of consumption is many, the time is long, patient lacks perseverance, often gives up halfway.

The object of the present invention is to provide a kind ofly can strengthen function of human body, improve immunity, can effectively prevent and treat senile disease, the preparation for senile disease of slow down aging.

The present invention is directed to the cause of multiple senile disease, smart withered, blood closes, involution of thymus, immune function is low, according to theory of Chinese medical science and clinical experience, select the nourishing the liver and kidney that has that medical circle generally acknowledges for use, spleen invigorating, benefiting QI and nourishing blood, strengthening the tendons and bones, dispelling wind and removing obstruction in the collateral, promote thymic hyperplasia, mediator's body immunity function, contain a large amount of vitamin again, the medicine of trace element, the Formica fusca that eats the senior tonic of dual-purpose curative effect-type is a principal agent, be equipped with the kidney invigorating again, spleen invigorating, tranquilizing by nourishing the heart, blood-activating stasis-removing kind Chinese medicine, employing is different from the preparation for senile disease that traditional new " like fermentation " production technology is produced, has medicine, the food compatibility, be easy to old age accept, easily digest and assimilate, tonification, get rid of illness and have both, the purpose that fundamentally reaching gets rid of illness lengthens the life.

Preparation for senile disease of the present invention, its characteristics are to include at least the medicine of following compositing range (percetage by weight):

Formica fusca 50-62

The kidney invigorating class medicine (A) 10-18

Spleen invigorating class medicine (B) 11-20

Tranquilizing by nourishing the heart class medicine (C) 6-10

Blood-activating stasis-removing kind thing (D) 4-8

Above-mentioned category-A medicine is meant at least a as in the kidney invigorating class Chinese medicines such as Herba Epimedii, Semen Sesami Nigrum, Rhizoma Polygonati, Cortex Acanthopancis, Fructus Cnidii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Rhizoma Curculiginis, Nidus Vespae, Fructus Lycii, Pericarpium Zanthoxyli; The category-B medicine is meant at least a as in the spleen invigorating class Chinese medicines such as Radix Ginseng, Poria, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali; C class medicine is meant at least a as in the tranquilizing by nourishing the heart class Chinese medicines such as Semen Ziziphi Spinosae, Ganoderma, bee pollen, Semen Nelumbinis, Poria cum Radix Pini, Caulis Polygoni Multiflori, Fructus Schisandrae Chinensis, Cortex Albiziae; D class medicine is meant at least a as in the blood-activating stasis-removing kind Chinese medicines such as Herba Leonuri, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Notoginseng, Pollen Typhae, Rhizoma Acori Graminei, Radix Et Rhizoma Rhei.

The present invention is when prescription, select at least a in Formica fusca and the kidney invigorating, spleen invigorating, tranquilizing by nourishing the heart, the multiple similar medicine of blood-activating stasis-removing kind respectively for use by the principles of formulating prescriptions of monarch, except that Formica fusca, the preferably assembly of multiple similar medicine of each class medicine, bring into play the synergism of multiple medicine, to obtain best curative effect.

The present invention according to the composition of theory of Chinese medical science, the principles of formulating prescriptions and clinical trial selection prescription, determines the content range of each composition when prescription.The relative amount preferably of determining various kinds of drug in the content range of each composition is also very important, and clinical practice and pharmacological research show, preparation for senile disease of the present invention, at following content range:

Formica fusca: A: B: C: D=100: 26-32: 26-34: 13-15: 9-11 (parts by weight) effect is better

In this scope, the present invention recommends to select for use following two assembly sides:

Formica fusca 100 Herba Epimedii 5-7 Semen Sesami Nigrum 3-5

Rhizoma Polygonati 4-6 Cortex Acanthopancis 4-6 Fructus Cnidii 5-7

Radix Codonopsis 5-7 Rhizoma Atractylodis Macrocephalae 4-6 Radix Astragali 3-5

Radix Polygoni Multiflori 5-7 Radix Rehmanniae Preparata 2-4 Semen Ziziphi Spinosae 3-5

Ganoderma 3-5 bee pollen 5-7 Semen Nelumbinis 0.5-2

Poria cum Radix Pini 0.5-2 Fructus Crataegi 1-3 Radix Notoginseng 1-3

Pollen Typhae 1-3 Rhizoma Acori Graminei 1-3 Radix Et Rhizoma Rhei 1-3

Pericarpium Citri Reticulatae 0.5-2 Radix Paeoniae Alba 4-6 Cordyceps 1-3

Formica fusca 100 Rhizoma Curculiginis 5-8 Nidus Vespae 3-5

Fructus Ligustri Lucidi 5-7 Fructus Lycii 7-10 Pericarpium Zanthoxyli 1-3

Radix Ginseng 6-8 Poria 3-5 Rhizoma Dioscoreae 5-7

Fructus Schisandrae Chinensis 5-7 Cortex Albiziae 3-5 Herba Leonuri 3-5

Rhizoma Chuanxiong 0.5-2 Radix Salviae Miltiorrhizae 3-5 Fructus Jujubae 0.5-2

Tremella 3-5 Caulis Polygoni Multiflori 3-5 Aspongopus 1-3

Eupolyphaga Seu Steleophaga 1-3 Fructus Chaenomelis 3-6 Fructus Mori 4-8

Preparation for senile disease of the present invention can also add removing mass medicine such as Semen Raphani (old people is how long-pending, excessive phlegm, the clear key of Yi Shangmeng); Awaking drug such as Radix Polygalae; Benefiting QI and nourishing blood medicine such as Arillus Longan with the lingering disease heresy of dispelling, buttress healthy energy, reach the purpose of vital QI recovered after pathogens eliminated.

In order to give full play to the drug effect of every herbal medicine in the preparation for senile disease of the present invention, the present invention has adopted the compound method that is different from Chinese medicine, characteristics mainly are various dissimilar classification of medicinal materials processing, and fine-powdered re-uses beans and Fructus Hordei Germinatus as " like the fermentation " production technology of drawing material, has fully extracted the active ingredient of the selected various natural animal-plant medical materials of the present invention, the effectiveness of medicine is given full play to, easily digest and assimilate, dose is little, and dosage form is various.Concrete processing method comprises:

1 will draw material Semen Glycines 2-4%, Semen sojae atricolor 0.5-2, Fructus Hordei Germinatus 0.5-2% like the fermentation of fermentation technology, and fermentation was ground into paste (promptly drawing material) with colloid mill after 24-36 hour in 20-40 degree container.

2. fresh animal kind medicines such as Formica fusca are added deionized water, grind to form paste with colloid mill.

3. viscosity and oil spice are put in the drying baker dry 12-24 hour at the 60-80 degree.

4 were put in the inherent 25-35 degree of drying baker dry 12-24 hour with the other medicines beyond 2,3, then its mixed powder were broken to the 70-80 order.

5. 3 spice is mixed mix homogeneously in 4 successively, be crushed to the 90-100 order together, below be referred to as full powder.

6. will draw material stick with paste be added to respectively that 2 animal kind medicines such as Formica fusca are stuck with paste and 5 full powder in, add deionized water respectively after, the former soaks down in room temperature and claimed animal to stick with paste in 12-24 hour, the latter soaks in the 28-40 degree and claimed branch powder lake in 24-36 hour.

Grind after paste of the animal after the immersion and Quan Fenhu mixing above-mentioned 6, add deionized water again, soaked 2-5 hour down in room temperature, agitation and filtration, room temperature soaked 1-2 hour down after filtering residue added deionized water again, before boil one hour after-filtration of pot, twice filtrate is mixed the back concentrating under reduced pressure and is got concentrated solution, adds 9-11% again and makes oral liquid through refined honey, bottling, pressure sterilizing, the packing of fine filtering.

1) powder: above-mentioned mixing spice is crushed to the 80-100 order, sieves, the packed products radiation sterilization.

2) pill: above-mentioned mixing spice is crushed to the 100-120 order, and per 100 gram fine powders restrain with an amount of water pill, are drying to obtain the finished product radiation sterilization with refined honey 50.

3) tablet: above-mentioned mixing spice is crushed to the 80-100 order, add accurate Rhizoma Dioscoreae fine powder as diluent, absorbent and disintegrating agent, and join a little lactose [or 7 parts of starch, 1 part in dextrin, 1 part of mixing of Icing Sugar] as diluent, with the distilled water is wetting agent, direct compression or sugar coating, the finished product radiation sterilization is carried out the total quality inspection by pharmacopeia, is used for after qualified clinical.

4) capsule (hard capsule)

Above-mentioned mixed material is crushed to the 100-120 order,, incapsulates the finished product radiation sterilization in 60-70 degree oven dry 2 hours.

Preparation for senile disease of the present invention, at the hypofunction of old people's internal organs, immunologic hypofunction, according to theory of Chinese medical science and clinical experience, select the nourishing the liver and kidney that has that medical circle generally acknowledges for use, spleen invigorating, benefiting QI and nourishing blood, strengthening the tendons and bones, dispelling wind and removing obstruction in the collateral, the Formica fusca of mediator's body immunity function is a principal agent, be aided with the kidney invigorating again, spleen invigorating, tranquilizing by nourishing the heart, blood-activating stasis-removing kind Chinese medicine is formulated, has replenishing essence, QI invigorating, logical abdomen, the function of nourshing blood and promoting blood circulation, can improve the internal organs function effectively, improve immunity, and the present invention is because employing is different from traditional new " like fermentation " production technology, therefore fully extracted the active ingredient in the crude drug, preparation for senile disease of the present invention is prevented and treated senile disease and is had better effect.

Embodiment one

1. 2 kilograms of Semen Glyciness, 0.5 kilogram of Semen sojae atricolor, 0.5 kilogram of Fructus Hordei Germinatus are added 3.75 kilograms of deionized waters, place in the container,, grind to form paste with colloid mill, hereinafter referred to as drawing material 37 ± 1 ℃ of bottom fermentations 26 hours.

2. with the polyrhachis of 1 kilogram of Cordyceps, 58 kilograms of work, add 5.9 kilograms of deionized waters, grind to form paste, stick with paste hereinafter referred to as animal with colloid mill.

3. 2 kilograms of Semen Sesami Nigrums, 2.5 kilograms of Rhizoma Polygonatis, 1.5 kilograms of Radix Rehmanniaes Preparata, 2 kilograms of Semen Ziziphi Spinosaes are put into far-infrared ray drying oven in 60 ± 1 ℃ of dryings 24 hours.

4. 3 kilograms of Herba Epimedii, 2,5 kilograms of Cortex Acanthopanciss, 3 kilograms of Radix Codonopsis, 2.5 kilograms of Rhizoma Atractylodis Macrocephalaes, 2 kilograms of Radixs Astragali, 3 kilograms of Fructus Cnidiis, 3 kilograms of Radix Polygoni Multiflori, 2 kilograms of Ganodermas, 3 kilograms of bee pollen, 0.5 kilogram of Semen Nelumbinis, 0.5 kilogram of Poria cum Radix Pini, 1 kilogram of Fructus Crataegi, 1 kilogram of Radix Notoginseng, 1 kilogram of Pollen Typhae, 1 kilogram of Rhizoma Acori Graminei, 1 kilogram of Radix Et Rhizoma Rhei, 0.5 kilogram of Pericarpium Citri Reticulatae, 2.5 kilograms of Radix Paeoniae Albas are put into far-infrared ray drying oven in 30 ± 1 ℃ of dryings 24 hours, then it is mixed and pulverize, its fineness is 75 orders.

5. 3 spice is mixed successively in 4 the mixed powder, be crushed to 95 orders together, below be referred to as full powder.

6. draw material respectively with 1 6.75 kilograms:

(1) add animal stick with paste in 3.98 kilograms, add 29.5 kilograms of deionized waters again and soaked 16 hours down in room temperature

(2) add in the full powder 2.77 kilograms, add 102.5 kilograms of deionized waters again and under 37 ± 1 ℃ of temperature, seemingly fermented 26 hours.

With above-mentioned 6:(1), (2) spice after processing mixes the back and grinds, the deionized water that adds 309 kilograms again soaked 3 hours down in room temperature, stir after-filtration, the deionized water that filtering residue adds 1 times of the surplus quantity of slag again soaked 1.5 hours down in room temperature, the back decocts to boil and filtered in 1 hour, twice filtrate is mixed back concentrating under reduced pressure (65 ℃), and fine filtering to get amount of liquid medicine be 270 kilograms, add 30 kilograms of the refined honeys of fine filtering again, after mixing, staticly settled 12 hours, fine filtering, bottling, pressure sterilizing, packing promptly gets the senile disease oral liquid I number.

The case history summary:

1. Xiao, woman, 57 years old, people from Shantou, Guangdong, on August 2nd, 1993, suddenly stupor is revived through rescue, after go to the People's Hospital, city to check to be diagnosed as: multiple diseases such as hypertension, cardiac cerebral arteriosclerosis, cervical spondylosis, rheumatoid, cholelithiasis, hepatitis B, take senile disease oral liquid of the present invention I number, every day secondary, each 20 milliliters, cause in December, 93 No. 18, blood pressure is steadily, rheumatoid disease is almost recovered, the every index of hepatitis B is normal, and other multiple symptoms disappear.

2. Zhang, woman 58 years old, ShenZhen,GuangDong people from city from little trouble asthma, increase the weight of in recent years, swoon in excuse in 1978 and remove how tame hospital diagnosis; Hypertension, cervical spondylosis, pulmonary heart disease through the multi-treatment poor effect, are taken senile disease oral liquid of the present invention I number in June, 1993, secondary, caused No. 20 various symptoms of in December, 1993 and disappeared substantially by each 20 milliliters every day, patient feels well, does not catch a cold again.

Embodiment two

With the medical material of following content (kilogram), 2 kilograms of Semen Glyciness, 0.5 kilogram of Semen sojae atricolor, 0.5 kilogram of Fructus Hordei Germinatus be for drawing material, makes the senile disease oral liquid II number by the method for embodiment one:

Formica fusca 56 Rhizoma Curculiginises 3 Nidus Vespae 2

Fructus Ligustri Lucidi 3 Fructus Lycii 4 Pericarpium Zanthoxylies 1

Radix Ginseng 3.5 Poria 2 Rhizoma Dioscoreaes 4

Fructus Schisandrae Chinensis 3 Cortex Albiziaes 2 Tremella 2

Fructus Mori 3 Herba Leonuris 2 Aspongopuss 1

Rhizoma Chuanxiong 0.5 Radix Salviae Miltiorrhizae 2 Eupolyphaga Seu Steleophagas 1

Fructus Chaenomelis 2.5 Fructus Jujubaes 0.5 Caulis Polygoni Multiflori 2

Wherein, Formica fusca, Aspongopus, Eupolyphaga Seu Steleophaga are the animal class: Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Mori, Fructus Jujubae, Rhizoma Chuanxiong are for containing viscosity and oil spice;

The case history summary:

Chen, woman, 46 years old, ShenZhen,GuangDong people from city, suffered from diabetes, rheumatoid, waist knee joint hyperosteogeny nearly 20 years, through the multi-treatment poor effect, take senile disease oral liquid of the present invention II number in July, 1993, every day secondary, each 20 milliliters, to No. 26, in December, 93, various symptoms disappear substantially, and existing other drug is all inactive, check repeatedly that through the Red Cross, the People's Hospital, city every index is all normal substantially, in the existing continuous clothes.

Claims

1. preparation for senile disease that is prepared from by natural Chinese medicine is characterized in that the component parts by weight of making said preparation are:

Formica fusca 100 Herba Epimedii 5-7 Semen Sesami Nigrum 3-5

Rhizoma Polygonati 4-6 Cortex Acanthopancis 4-6 Fructus Cnidii 5-7

Radix Codonopsis 5-7 Rhizoma Atractylodis Macrocephalae 4-6 Radix Astragali 3-5

Ganoderma 3-5 bee pollen 5-7 Rhizoma Acori Graminei 1-3

Radix Et Rhizoma Rhei 1-3 Pericarpium Citri Reticulatae 0.5-2 Radix Paeoniae Alba 4-6

Cordyceps 1-3 Semen Nelumbinis Poria cum Radix Pini 0.5-2 0.5-2

Fructus Crataegi 1-3 Radix Notoginseng 1-3 Pollen Typhae 1-3,

Method is divided into following steps:

1) fermentation is drawn material Semen Glycines 2-4%, Semen sojae atricolor 0.5-2%, Fructus Hordei Germinatus 0.5-2%, fermentation ground to form paste with colloid mill after 24-36 hour in 20-40 degree container, must draw material and stick with paste;

2) fresh Formica fusca is added deionized water, grind to form paste with colloid mill;

3) viscosity and oil spice are put in the drying baker dry 12-24 hour at the 60-80 degree;

4) with 2), 3) in addition other drug is put in the drying baker, dry 12-24 hour of 25-35 degree, then its mixed powder is broken to the 70-80 order;

5) with 3) spice mix in 4 successively) in mix homogeneously, be crushed to the 90-100 order together, full powder;

6) will draw material stick with paste be added to 2 respectively) Formica fusca mass and 5) full powder in, add deionized water respectively after, the former soaked 12-24 hour down in room temperature, the animal paste; The latter soaked 24-36 hour in the 28-40 degree, got full powder and stuck with paste;

7) with above-mentioned 6) the gained animal is stuck with paste and full powder is stuck with paste mixing, promptly.