CN1562116A - Chinese medicine preparation with invigorating kidney function - Google Patents
Chinese medicine preparation with invigorating kidney function Download PDFInfo
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- CN1562116A CN1562116A CN 200410010762 CN200410010762A CN1562116A CN 1562116 A CN1562116 A CN 1562116A CN 200410010762 CN200410010762 CN 200410010762 CN 200410010762 A CN200410010762 A CN 200410010762A CN 1562116 A CN1562116 A CN 1562116A
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Abstract
A Chinese medicine for invigorating the function of kidney and delaying sanility is prepared from 21 Chinese-medicinal materials including antler glue, wolfberry fruit, deer penis, stragalus root, etc.
Description
Technical field:
The present invention discloses a kind of Chinese medicine preparation with strong renal function, has the effect of life essence-filling, marrow-benefitting and kidney invigorating, and relating to the Chinese herbal medicine is the kidney invigorating technical field of pharmaceuticals that raw material is made.
Background technology:
Deficiency of kidney-essence can cause bleary-eyed dizzy, forgetful weak, soreness of the waist and knees, knowledge is become deaf, vexed dreaminess, diseases such as seminal emission, the kidney invigorating medicine commonly used adopt famous and precious Chinese herbal medicine or the positive tool of animal mostly, and the cost of medicine is higher, patient economy burden is excessive, curative effect is not remarkable yet, even the medicine that has also has very big toxic and side effects, has influenced the treatment of deficiency of the kidney disease of patient.
Summary of the invention:
The invention provides a kind of Chinese medicine preparation with strong renal function, have evident in efficacy, cheap, the characteristics of the life essence-filling, marrow-benefitting and kidney invigorating that toxic and side effects is little.
Technical solution of the present invention is as follows; According to kidney storing essence, main bone is given birth to marrow, leads in brain, has one's ideas straightened out in ear; Blood stored in the liver, main catharsis, main muscle is had one's ideas straightened out in order; Heart storing spirit, the theory of Chinese medical science of controlling blood and vessel, from life essence-filling, marrow-benefitting, benefiting QI and nourishing blood, the Liver and kidney giving young employees remedial-courses in general knowledge and vocational skills, the Therapeutic Principle that heart kidney two is transferred starts with, and selected Chinese herbal medicine with curative effect from the medical treasure-house of motherland is made the present invention by ratio of weight and the number of copies:
Colla cornus cervi 10～15, Fructus Lycii 58～65, Penis et testis cervi (scalding) 2～5, the Radix Astragali 55～65,
Testis et Pentis Canis (scalding) 15～20, Rhizoma Cibotii (scalding) 100～150, Testis Et penis Equi (scalding) 10～15,
Radix Rehmanniae Preparata 100～150, Hippocampus (shortcake) 2～5, Herba Cistanches 50～70, Concha Ostreae (forging) 100～150,
Semen Allii Tuberosi (stir-fry) 100～150, Penaeus seu panulirus 10～15, Herba Cynomorii 50～65, Radix Ginseng Rubra 20～35,
Fructus Psoraleae (processed with salt) 50～65, Herba Epimedii (system) 50～65, the Cortex Eucommiae (charcoal) 25～35,
Cortex Cinnamomi (removing rough bark) 20～30, Radix Achyranthis Bidentatae 50～65, Semen Cuscutae (processed with wine) 50～65.
Processing procedure of the present invention is as follows: above 20 simply, and except that Herba Epimedii, Fructus Lycii, Herba Cistanches, Radix Rehmanniae Preparata four flavors, 17 flavors such as all the other Radixs Astragali are ground into fine powder, cross 100 mesh sieves.Herba Cistanches and Radix Rehmanniae Preparata are added 6～8 times of decoctings boil 2～4 times, be respectively 3～1 hours, collecting decoction filters; With Herba Epimedii, Fructus Lycii with 60～90% soak with ethanol reflux, extract, secondary after 0.5～1.5 hour, each 1～2 hour, merge reflux extracting liquid, filter, reclaim ethanol.Merge above extracting solution, be condensed into the thick paste that relative density is about 1.20 (60 ℃ of surveys), drying under reduced pressure is pulverized, and sieves, and adds fine powders such as the above-mentioned Radix Astragali, and mix homogeneously is cooked disintegrating agent with 10% starch that is about total amount, uses water pill, makes 1000g, drying, promptly.
[character] this product is the tan watered pill; Gas is special, lightly seasoned, little raw meat.
[function cures mainly] kidney invigorating and YANG supporting, benefiting QI and nourishing blood.Be used for insufficiency of kidney-YANG, deficient qi and blood.
[usage and dosage] is oral, a 3.5g, 2 times on the one.
[points for attention] hyperactivity of fire caused by deficiency of YIN, the dysphoria with feverish sensation in the chest palms and soles person avoids usefulness.
The present invention by 20 simply Chinese medicine form, wherein seven flavor medicine things such as Colla cornus cervi, Penis et testis cervi, Testis Et penis Equi, Hippocampus are animal drugs, account for full side's 1/3rd, ancient claim that animal drugs is the in love product of flesh and blood, original flavor is deep, is just accord with the main points of " tonifying with drugs of thick flavor ".
Take a broad view of monarch's usefulness Herba Epimedii, Herba Cistanches, Colla cornus cervi, Radix Ginseng Rubra in all prescriptions.The lid kidney is the origin of human body, and the gas that kidney is hidden is the vigour of life, is again that water is dirty, is responsible for five liquid, and life-span length, deficient impairment caused by overstrain are decided by the prosperity and decline of vigour, and filling of essence (blood) gas is prosperous.The Herba Cistanches sweet in the mouth is sour and salty, warm in nature, goes into kidney channel, has the effect of nourishing kidney enrich and benefit essence and blood.Colla cornus cervi acid is salty and warm, enriching blood and replenishing vital essence, and the dredging DU Meridian arteries and veins is mended the gate of vitality, mends and can loose, mends greatly and little stagnant, and the master is at enrich and benefit essence and blood.The sweet temperature of Radix Ginseng Rubra, the disease of all qi-blood-body fluid deficiencies of tonification, Colla cornus cervi and Radix Ginseng Rubra share, qi and blood tonifying, four medicines are harmonious, and make kidney yang gas prosperous, and essence and blood must fill, and is listed as principal agent, cures mainly insufficiency of kidney-YANG, the card of deficiency of qi and blood.
Minister is with Fructus Psoraleae, Herba Cynomorii, Penis et testis cervi, Testis et Pentis Canis, Semen Allii Tuberosi, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Psoraleae reinforcing the kidney and supporting YANG.The Herba Cynomorii merit is in the kidney invigorating intestine moistening.Penis et testis cervi has the function of the kidney invigorating, tonifying YANG, controlling nocturnal emission with astringent drugs.Testis et Pentis Canis has invigorating the spleen and replenishing QI, the function that nourishing kidney is supporing yang.Semen Allii Tuberosi use invigorating the liver and kidney, warm waist knee joint.Xing Yangdao controls sexual impotence.Five tastes medicine phase 5, the effect of auxiliary monarch drug performance kidney invigorating and YANG supporting.Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae are harmonious, merit nourishes blood in nourishing the liver and kidney, cooperates the power of Colla cornus cervi, Radix Ginseng Rubra, Herba Cistanches performance hemopoietic QI invigorating, is combined into usefulness mutually with Fructus Psoraleae, Herba Cynomorii, Penis et testis cervi, Testis et Pentis Canis, the Semen Allii Tuberosi of warming the kidney to activate YANG, be intended to coordination of YIN and YANG, guiding QI in YIN meridian to expel the pathogen in YANG meridian, guiding QI in YANG meridians to expel the pathogen in YIN meridian, thus reach Yin grows while yang is generating, the purpose that cloudy long sun is given birth to, eight herbal medicines are combined into minister mutually, and principal drug assistance is brought into play the kidney invigorating warming YANG, the effect that spermatogenesis nourishes blood altogether.
Assistant is with Testis Et penis Equi, the Radix Astragali, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Hippocampus, dried shrimps, Testis et Pentis Canis, Concha Ostreae.Radix Ginseng Rubra, the Radix Astragali, Colla cornus cervi, Testis Et penis Equi cooperate with Radix Rehmanniae Preparata, Fructus Lycii, Semen Cuscutae, amount to the merit of vigorate qi and replenish the blood, and the reason of residence essence and blood alternate.The Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Cibotii can invigorating the liver and kidney and bone and muscle strengthening.Radix Achyranthis Bidentatae: control sexual impotence, kidney tonifying, essence replenishing.Rhizoma Cibotii energy " strong Liver and kidney is good for bone, is controlled wind disease ".Dried shrimps, Hippocampus merit are in kidney invigorating and YANG supporting, and auxiliary ministerial drug is brought into play the effect of its kidney invigorating and YANG supporting.Concha Ostreae master man seminal emission, asthenia is weary to be decreased, and the kidney invigorating healthy energy and Radix Rehmanniae mutually 5 can " beneficial smart astringent therapy be only urinated, and the medicine of this kidney channel is also ".
Make with meat good.Hot sweet and hot, go into the kidney spleen channel, and the energy kidney-Yang invigorating, warm spleen kidney, removing accumulated cold, promoting blood circulation.
All medicine compatibilities, the effect of playing kidney invigorating and YANG supporting, benefiting QI and nourishing blood altogether cures mainly all diseases of strain of insufficiency of kidney-YANG, deficiency of qi and blood.
For showing the curative effect of medicine of the present invention, in January, 1998～March, 180 routine syndrome of deficiency of kidney-YANG patients have been carried out clinical observation and comparative study by the attached doctor of Changchun Traditional Chinese Medical College, Changchun institute of traditional Chinese medicine, Changchun worker's hospital of automobile factory, now the result is reported as follows:
Clinical data
Meet experiment case standard person 180 routine patients, be divided into observation group's 120 examples at random, inpatient 50 examples wherein, out-patient's 70 examples; Matched group 60 examples, inpatient 33 examples wherein, out-patient's 27 examples.
One, diagnostic criteria
Formulate with reference to " new Chinese medicine clinical know principle ".
1, sexual impotence: during between twenty and fifty man's sexual intercourse,, and cause can not carrying out more than 75% of sexual intercourse chance, can be diagnosed as sexual impotence because penis can not effectively erect.
2, premature ejaculation: during sexual intercourse, penis does not insert vagina as yet, and both sides do not contact as yet or rigidly connect and touch, or, insert the ejaculation at once in 1 minute of back less than, so that can not carry out normal sexual intercourse, continue person more than 1 month, can be diagnosed as primary disease.
Two, curative effect determinate standard
(2), YANG asthenia disease curative effect determinate standard: formulate with reference to " new Chinese medicine clinical research guideline ".
1, clinical recovery: the symptom of insufficiency of kidney-YANG, sign disappears; If the physics and chemistry reference index of deficiency of kidney-YANG syndrome is arranged, should be normal substantially.
2, produce effects: the symptom of insufficiency of kidney-YANG, sign are obviously improved (or treatment back symptom integral value descends＞2/3), if the physics and chemistry reference index of deficiency of kidney-YANG syndrome is arranged, obvious improvement should be arranged.
3, effective: the symptom of insufficiency of kidney-YANG, sign all take a favorable turn (or treatment back symptom integral value descends between 2/3～1/3); If the physics and chemistry reference index of syndrome of deficiency of kidney-YANG is arranged, corresponding improvement should be arranged.
4, invalid: the symptom of insufficiency of kidney-YANG, sign do not have and improve (or treatment back symptom integral value descends not as good as 1/3); And the physics and chemistry reference index of syndrome of deficiency of kidney-YANG is arranged, also there is not improvement.
(2), the curative effect determinate standard of sexual impotence: formulate with reference to " new Chinese medicine clinical research guideline ".
1, cures in the recent period; Treatment back erection＞90 °, the energy success more than 75% of sexual intercourse chance.2, produce effects: erect＞90 ° in the treatment back, and 50% of sexual intercourse chance can success.3, effective: erect improvement arranged in the treatment back, the energy success more than 25% of sexual intercourse chance.4, invalid; Every index does not all have improvement before and after the medication.
(3), premature ejaculation curative effect determinate standard: formulate with reference to " new Chinese medicine clinical research guideline ".
1, cure in the recent period: after the treatment, sexual intercourse all can success.
2, produce effects; 75% above sexual intercourse chance has the sexual life of success, and the ejaculation time is all in sexual intercourse after 1 minute.
3, effective: as to insert vagina during sexual intercourse, sexual intercourse ejaculation later in 1 minute under the part situation.
4, invalid: before and after the treatment, all diseases do not become.
Comparative study result to strong kidney ball (honeyed pill) treatment of medication treatment and matched group Aodong syndrome of deficiency of kidney-YANG 60 examples of syndrome of deficiency of kidney-YANG 120 examples shows by medicine of the present invention:
1, to treat the total effective rate of deficiency of kidney-YANG syndrome be 90.83% in the present invention, cure-remarkable-effectiveness rate is 38.33%, and matched group is respectively 86.67%, 38.33%, the two is there was no significant difference (P＞0.10) relatively, the two is to the soreness of waist and knee joint of deficiency of kidney-YANG syndrome, aversion to cold and cold limbs, hyposexuality, light red tongue is fat, tongue is white, deep pulse, deficient syndrome shape, sign all have the obvious treatment effect.
2, the present invention's total effective rate, cure-remarkable-effectiveness rate for the treatment of sexual impotence is respectively 88.89%, 90.16% no significant difference of comparing with matched group 90.00%, 40%.
Total effective rate, the cure-remarkable-effectiveness rate that 3 the present invention treat premature ejaculation is respectively 89.47%, 42.11% and compares no significant difference with matched group 83.33%, 26.67%.
4, the present invention has tangible kidney invigorating and Yang strengthening function: all there are obvious potentiation sexual intercourse number of times, sexual intercourse ejaculation persistent period to the insufficiency of kidney-YANG patient, have obtained and the corresponding to action effect of matched group.
In sum, the present invention has tangible kidney invigorating and Yang strengthening function, does not see that clinically any poison pays effect.
Good effect of the present invention is: be pure Chinese medicinal preparation, have life essence-filling, marrow-benefitting, benefiting QI and nourishing blood, the Liver and kidney giving young employees remedial-courses in general knowledge and vocational skills, heart kidney two is transferred, and grows and oiliness, the tonify without causing stagnation effect is taken for a long time, the energy the kidney invigorating, benefit marrow, QI invigorating and blood producing, nourishing blood to tranquillize the mind helps the recovery of whole body function, receive that the kidney invigorating is also few, function in delaying senility.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope of the present invention.
Embodiment 1:
Take by weighing Colla cornus cervi 12.5g, Fructus Lycii 62.5g, Penis et testis cervi (scalding) 3.125g, Radix Astragali 62.5g, Testis et Pentis Canis (scalding) 18.75g, Rhizoma Cibotii (scalding) 125g, Testis Et penis Equi (scalding) 12.5g, Radix Rehmanniae Preparata 125g, Hippocampus (shortcake) 3.125g, Herba Cistanches 62.5g, Concha Ostreae (forging) 125g, Semen Allii Tuberosi (stir-fry) 125g, Penaeus seu panulirus 12.5g, Herba Cynomorii 62.5g, Radix Ginseng Rubra 25g, Fructus Psoraleae (processed with salt) 62.5g, Herba Epimedii (system) 62.5g, the Cortex Eucommiae (charcoal) 31.25g, Cortex Cinnamomi (removing rough bark) 25g, Radix Achyranthis Bidentatae 62.5g, Semen Cuscutae (processed with wine) 62.5g.
More than 20 simply, except that Herba Epimedii, Fructus Lycii, Herba Cistanches, Radix Rehmanniae Preparata four flavors, 17 flavors such as all the other Radixs Astragali are ground into fine powder, cross 100 mesh sieves.Herba Cistanches and Radix Rehmanniae Preparata are decocted with water three times, be respectively 2,2,1 hours, collecting decoction filters; With Herba Epimedii, Fructus Lycii with 70% soak with ethanol reflux, extract, secondary after half an hour, each 2 hours, merge reflux extracting liquid, filter, reclaim ethanol.Merge above extracting solution, be condensed into the thick paste that relative density is about 1.20 (60 ℃ of surveys), drying under reduced pressure is pulverized, and sieves, and adds fine powders such as the above-mentioned Radix Astragali, and mix homogeneously is cooked disintegrating agent with 10% starch that is about total amount, uses water pill, makes 1000g, drying, promptly.
Embodiment 2:
Get Colla cornus cervi 12.5g, Fructus Lycii 62.5g, Penis et testis cervi (scalding) 3.125g, Radix Astragali 62.5g, Testis et Pentis Canis (scalding) 18.75g, Radix Rehmanniae Preparata 125g, Herba Cistanches 62.5g, Semen Allii Tuberosi (stir-fry) 125g, Herba Cynomorii 62.5g, Radix Ginseng Rubra 25g, Fructus Psoraleae (processed with salt) 62.5g, Herba Epimedii (system) 62.5g, Semen Cuscutae (processed with wine) 62.5g.Corresponding processing procedure according to embodiment 1 extracts respectively, will take by weighing 1kg after the extract mixing separately, in addition taking polyethylene glycol 4000 15g, heating and melting, temperature remains on 70～80 ℃, adds the said extracted thing respectively, is transferred in the reservoir rapidly after stirring.Airtight and insulation is dripped system at 80 ℃ from top to bottom with dosing pump drop pill machine, drip fast 30 balls/minute, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back fill to be dried is packed, promptly.
Other project should meet 2000 editions drop pill projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 3:
Get Colla cornus cervi 12.5g, Fructus Lycii 62.5g, Penis et testis cervi (scalding) 3.125g, Radix Astragali 62.5g, Testis et Pentis Canis (scalding) 18.75g, Rhizoma Cibotii (scalding) 125g, Testis Et penis Equi (scalding) 12.5g, Radix Rehmanniae Preparata 125g, Hippocampus (shortcake) 3.125g, Herba Cistanches 62.5g, Concha Ostreae (forging) 125g, Semen Allii Tuberosi (stir-fry) 125g, Penaeus seu panulirus 12.5g, Herba Cynomorii 62.5g, Radix Ginseng Rubra 25g, Fructus Psoraleae (processed with salt) 62.5g, Herba Epimedii (system) 62.5g, the Cortex Eucommiae (charcoal) 31.25g, Cortex Cinnamomi (removing rough bark) 25g, Radix Achyranthis Bidentatae 62.5g, Semen Cuscutae (processed with wine) 62.5g.Press embodiment 1 processing procedure and extract, take by weighing 1kg after the extract mixing with each herbal medicine, medical starch 0.4kg, with 80% ethanol wet granulation, granulate, dress 1# capsule, every 0.25g.
Other project should meet 2000 editions capsule items of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 4:
Get the extract mixtures 1kg of each herbal medicine of embodiment 3, medical starch 0.5kg, dextrin 1kg, 50% ethanol is granulated in right amount, granulate, drying, tabletting.Every 0.3g.
Or get the extract mixtures 1kg of each herbal medicine of embodiment 2, and citric acid 0.1kg, sodium bicarbonate 0.1kg, an amount of tabletting of magnesium stearate, promptly.Every 0.5g.
Other project should meet 2000 editions tablet projects of Pharmacopoeia of People's Republic of China relevant requirements.
Claims (5)
1, a kind of Chinese medicine preparation with strong renal function is characterized in that being made by following raw medicaments in portion by weight:
Colla cornus cervi 10～15, Fructus Lycii 58～65, boiling hot Penis et testis cervi 2～5, boiling hot Testis et Pentis Canis 15～20, Radix Rehmanniae Preparata 100～150, Herba Cistanches 50～70, stir-fry Semen Allii Tuberosi 100～150, Radix Ginseng Rubra 20～35, Herba Cynomorii 50～65, processed with salt Fructus Psoraleae 50～65, Herba Epimedii (processed) 50～65, processed with wine Semen Cuscutae 50～65.
2, Chinese medicine preparation according to claim 1 is characterized in that crude drug also has:
The Radix Astragali 55～65, boiling hot Rhizoma Cibotii 100～150, boiling hot Testis Et penis Equi 10～15, crisp Hippocampus 2～5, Concha Ostreae (calcined) 100～150, Penaeus seu panulirus 10～15, the charcoal Cortex Eucommiae 25～35, Cortex Cinnamomi 20～30, Radix Achyranthis Bidentatae 50～65.
3, Chinese medicine preparation according to claim 2 is characterized in that the consumption of each component is: Colla cornus cervi 12.5g, Fructus Lycii 62.5g, boiling hot Penis et testis cervi 3.125g, Radix Astragali 62.5g, boiling hot Testis et Pentis Canis 18.75g, boiling hot Rhizoma Cibotii 125g, boiling hot Testis Et penis Equi 12.5g, Radix Rehmanniae Preparata 125g, crisp hippocampus 3 .125g, Herba Cistanches 62.5g, Concha Ostreae (calcined) 125g, stir-fry Semen Allii Tuberosi 125g, Penaeus seu panulirus 12.5g, Herba Cynomorii 62.5g, Radix Ginseng Rubra 25g, processed with salt Fructus Psoraleae 62.5g, Herba Epimedii (processed) 62.5g, charcoal Cortex Eucommiae 31.25g, Cortex Cinnamomi 25g, Radix Achyranthis Bidentatae 62.5g, processed with wine Semen Cuscutae 62.5g.
4, according to any medicine production technology described in the claim 1-3, may further comprise the steps: above 20 simply, except that Herba Epimedii, Fructus Lycii, Herba Cistanches, Radix Rehmanniae Preparata four flavors, all the other ten seven flavor medicine things are ground into fine powder, cross 100 mesh sieves, Herba Cistanches and Radix Rehmanniae Preparata are added 6～8 times of decoctings boil 2～4 times, be respectively 3～1 hours, collecting decoction filters; Herba Epimedii, Fructus Lycii with 60～90% soak with ethanol reflux, extract, secondary after 0.5～1.5 hour, each 1～2 hour, are merged reflux extracting liquid, filter, reclaim ethanol, merge above extracting solution, be condensed into relative density and be about 1.20 thick paste, drying under reduced pressure, pulverize, sieve, add fine powders such as the above-mentioned Radix Astragali, mix homogeneously, promptly.
5, can be said dosage form on any pharmaceutics according to any medicine described in the claim 1-3.
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| CN102836272B (en) * | 2012-09-10 | 2014-10-15 | 王仲举 | Medicinal composition for treating prostate hyperplasia |
| CN105770062A (en) * | 2016-03-24 | 2016-07-20 | 李力 | Medicine for treating nephrosis |
| CN109481558A (en) * | 2018-12-18 | 2019-03-19 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Chinese medicine composition is preparing the application in fatigue proof drug |
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