CN105727139A - Composition for treating gastrointestinal diseases, preparation method thereof and medicine made from composition - Google Patents

Composition for treating gastrointestinal diseases, preparation method thereof and medicine made from composition Download PDF

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Publication number
CN105727139A
CN105727139A CN201610173481.5A CN201610173481A CN105727139A CN 105727139 A CN105727139 A CN 105727139A CN 201610173481 A CN201610173481 A CN 201610173481A CN 105727139 A CN105727139 A CN 105727139A
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parts
parched
brown
medicine
fructus
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王伟民
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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Abstract

The invention provides a composition for treating gastrointestinal diseases, a preparation method of the composition and a medicine prepared from the composition. The composition is mainly prepared from the following components: 5-15 parts of rhizoma cyperi, 4-13 parts of fructus amomi, 10-30 parts of dried tangerine or orange peel, 1-5 parts of processed pinellia tuber, 10-25 parts of radix codonopsis, 10-30 parts of poria cocos, 1-6 parts of rhizoma atractylodis macrocephalae stir-fried with bran, 2-10 parts of Chinese yam, 10-30 parts of white hyacinth beans, 1-9 parts of endothelium corneum gigeriae galli, 2-10 parts of scorched medicated leaven, 2-10 parts of scorched malt, 2-10 parts of scorched hawthorn fruit, 5-20 parts of raw hawthorn fruit, 1-9 parts of semen raphani, 10-25 parts of astragalus, 10-30 parts of clove, 4-13 parts of nutmeg, 5-15 parts of cortex magnoliae officinalis, 5-15 parts of costusroot, 5-15 parts of white paeony root, 1-5 parts of liquorice and 2-7 parts of Chinese date. Multiple components are mutually combined and have positive synergistic effect, and the gastrointestinal diseases can be thoroughly cured when the composition is used for treating the gastrointestinal diseases.

Description

The treatment compositions of gastroenteropathy, preparation method and the medicine being made from Thing
Technical field
The present invention relates to compositions field, treat the intestines and stomach disease in particular to one The compositions of disease, preparation method and the medicine being made from.
Background technology
Gastroenteropathy is a kind of common multiple disease being difficult to and treating, and does not heals Chronic disease is in the majority, such as chronic gastritis, chronic enteritis, reflux esophagitis, colitis, straight Enteritis etc..These gastroenteropathys usually can cause flatulence, belching and acid regurgitation, inappetence, Become thin the malaise symptoms such as loose stool, fatigue and weakness, affect orthobiosis and the work of people.Especially It is the modern society accelerated in rhythm of life, and the operating pressure of people is relatively big, drinks in addition Eat the irregular impact waiting many factors so that the ratio that modern suffers from gastroenteropathy increases Add.
Owing to gastroenteropathy can cause the gastrointestinal function of patient to die down, therefore, Western medicine is used to control When treating this kind of disease, it is more fragile that Long-term taking medicine sometimes results in gastrointestinal function, is formed pernicious Circulation.And, when using western medicine, sometimes it is only capable of alleviating slight illness at short notice, but It is unable to reach the purpose of radical cure.Patient is after drug withdrawal, if not noting the protection to the intestines and stomach, this A little gastroenteropathys easily recur.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of compositions treating gastroenteropathy.This group Compound is treating chronic enteritis, chronic gastritis, colitis, proctitis etc. for existing medicine The problem cured the symptoms, not the disease existed during gastroenteropathy, collaborative by 23 kinds of active components is joined 5, when treating gastroenteropathy, it is possible to invigorating the spleen and benefiting QI and stomach and alleviating pain, antidiarrheal, emesis, Promoting digestion and removing stagnation, debulking antacid, increase appetite, same in rapid recovery symptom management symptom Time, have the intestines and stomach coordinating concurrently so that the function of impaired the intestines and stomach is progressively recovered, thus fundamentally Cure gastroenteropathy.
The second object of the present invention is to provide a kind of medicine being prepared from by above-mentioned composition Thing, had both ensured drug effect, and patient can be facilitated again to take.
The third object of the present invention is to provide the preparation method of a kind of above-mentioned composition.This system Preparation Method has advantage easily and fast.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
Treatment gastroenteropathy compositions, in parts by weight, mainly prepared by following components and Become:
Rhizoma Cyperi 5-15 part, Fructus Amomi 4-13 part, Pericarpium Citri Reticulatae 10-30 part, Rhizoma Pinelliae Preparatum 1-5 part, party Ginseng 10-25 part, Poria 10-30 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 1-6 part, Rhizoma Dioscoreae 2-10 part, the most flat Bean 10-30 part, Endothelium Corneum Gigeriae Galli 1-9 part, Massa Medicata Fermentata (parched to brown) 2-10 part, Fructus Hordei Germinatus (parched to brown) 2-10 part, Jiaoshan Hill Short, bristly hair or beard 2-10 part, Fructus Crataegi 5-20 part, Semen Raphani 1-9 part, Radix Astragali 10-25 part, Flos Caryophylli 10-30 part, Semen Myristicae 4-13 part, Cortex Magnoliae Officinalis 5-15 part, Radix Aucklandiae 5-15 part, Radix Paeoniae Alba 5-15 Part, Radix Glycyrrhizae 1-5 part and Fructus Jujubae 2-7 part.
The compositions that the present invention provides, scientific formulation is reasonable, specifically, composite formula Principle as follows:
Monarch drug in formula include Pericarpium Citri Reticulatae, Poria, Semen Lablab Album, Radix Codonopsis, the Radix Astragali and Flos Caryophylli this 6 kinds of components.Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm；Poria spleen invigorating mind calming, has diuretic concurrently and oozes Wet；Semen Lablab Album invigorating the spleen for eliminating dampness, and in relieve summer heat；Radix Codonopsis invigorating the spleen and replenishing QI, stomach function regulating promotes the production of body fluid, and eliminates the phlegm Cough-relieving；Radix Astragali qi-restoratives, consolidating superficial resistance；Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG, they are as monarch drug Use, cooperate, play effect of spleen invigorating, QI invigorating, fundamentally the intestines and stomach coordinating, by Step is recovered and improves the normal function of impaired the intestines and stomach.
Ministerial drug in allocation include Rhizoma Cyperi, Fructus Amomi, Semen Myristicae, Cortex Magnoliae Officinalis, the Radix Aucklandiae and the Radix Paeoniae Alba this 6 kinds of components.Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving；Fructus Amomi is warm in nature, acrid in the mouth, Have warming the spleen and kidney, therapeutic method to keep the adverse QI flowing downwards pain relieving, the chest stuffiness relieving diaphragm, dredge the stagnation of QI, except vomiting, increase appetite, only Cold diarrhea, whet the appetite, change effect stagnant, that help digestion；Semen Myristicae warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents；Thick Piao's removing dampness by means of aromatics, regulating the flow of QI to ease the stomach；Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion；Radix Paeoniae Alba nourishing blood for regulating menstruation, Astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG, they use as ministerial drug, it is possible to stomach function regulating, Pain relieving, antidiarrheal, emesis, eliminate the pain that gastroenteropathy brings to patient.
Adjuvant drug in formula include Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata (parched to brown), Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and These 6 kinds of components of Semen Raphani.Chinese yam spleen-strengtheningporridge stomach reinforcing is aid digestion；Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion is puckery Essence is only lost, treating stranguria fossil；Massa Medicata Fermentata (parched to brown) is warm in nature, returns taste warp, has promoting digestion and removing stagnation, spleen invigorating Effect of stomach function regulating；Fructus Hordei Germinatus (parched to brown) is aid digestion；Semen Raphani removing food stagnancy is stagnant, heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, Removing toxic substances, they use as adjuvant drug, it is possible to promoting digestion and removing stagnation, debulking antacid.
In formula make medicine include Rhizoma Pinelliae Preparatum, Rhizoma Atractylodis Macrocephalae (parched with bran), Fructus Crataegi, Radix Glycyrrhizae and Fructus Jujubae this 5 Plant component, be combined with monarch drug, ministerial drug and adjuvant drug and use, it is possible to coordinating the actions of various ingredients in a prescription, simultaneously can also Enough play and increase effect of appetite.
In sum, through mutual compatibility between each component of compositions that the present invention provides, rise Arrive positive synergism, when being used for treating gastroenteropathy, be not only able to take stopgap measures, simultaneously Can also effect a permanent cure, while rapid recovery symptom management symptom, have the intestines and stomach coordinating concurrently, make The function obtaining impaired the intestines and stomach is progressively recovered, thus fundamentally cures gastroenteropathy.
The said composition that the present invention provides, verifies through Long-term clinical, the group that the present invention provides When compound is for treating all kinds of common gastroenteropathy, not only can quickly take stopgap measures, and pass through After the treatment of 1-3 month, additionally it is possible to reach the effect taken stopgap measures, make the normal function of the intestines and stomach obtain To recover.
The consumption of each component in formula also contributes to the using effect of compositions, each component Optimum (in parts by weight) is: Rhizoma Cyperi 5-15 part, Fructus Amomi 4-13 part, Pericarpium Citri Reticulatae 10-30 Part, Rhizoma Pinelliae Preparatum 1-5 part, Radix Codonopsis 10-25 part, Poria 10-30 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 1-6 part, Rhizoma Dioscoreae 2-10 part, Semen Lablab Album 10-30 part, Endothelium Corneum Gigeriae Galli 1-9 part, Massa Medicata Fermentata (parched to brown) 2-10 part, Jiao Fructus Hordei Germinatus 2-10 part, Fructus Crataegi (parched to brown) 2-10 part, Fructus Crataegi 1-6 part, Semen Raphani 1-9 part, the Radix Astragali 10-25 part, Flos Caryophylli 10-30 part, Semen Myristicae 4-13 part, Cortex Magnoliae Officinalis 5-15 part, Radix Aucklandiae 5-15 Part, Radix Paeoniae Alba 5-15 part, Radix Glycyrrhizae 1-5 part, Fructus Jujubae 2-7 part.Preferably, described Rhizoma Cyperi is 10-14 part, described Fructus Amomi be 10-12 part, described Pericarpium Citri Reticulatae be 15-20 part, described Rhizoma Pinelliae Preparatum For 3-5 part, described Radix Codonopsis be 15-20 part, described Poria be that 15-20 part, described parched with bran are white Art be 3-6 part, described Rhizoma Dioscoreae be 5-10 part, described Semen Lablab Album be 15-20 part, described chicken Endothelium corneum be 5-9 part, described Massa Medicata Fermentata (parched to brown) be 7-10 part, described Fructus Hordei Germinatus (parched to brown) be 7-10 part, described Fructus Crataegi (parched to brown) be 7-10 part, described Fructus Crataegi be 3-6 part, described Semen Raphani be 5-9 part, institute State the Radix Astragali be 15-18 part, described Flos Caryophylli be 15-20 part, described Semen Myristicae be 10-12 part, Described Cortex Magnoliae Officinalis be 10-15 part, the described Radix Aucklandiae be 10-14 part, the described Radix Paeoniae Alba be 10-14 part, Described Radix Glycyrrhizae be 3-5 part, described Fructus Jujubae be 4-7 part.Most preferably, described Rhizoma Cyperi is 12-13 Part, described Fructus Amomi be 11-12 part, described Pericarpium Citri Reticulatae be 18-20 part, described Rhizoma Pinelliae Preparatum be 4-5 Part, described Radix Codonopsis be 15-16 part, described Poria be that 18-20 part, described Rhizoma Atractylodis Macrocephalae (parched with bran) are 5-6 part, described Rhizoma Dioscoreae be 8-10 part, described Semen Lablab Album be 16-18 part, described Endothelium Corneum Gigeriae Galli For 8-9 part, described Massa Medicata Fermentata (parched to brown) be 9-10 part, described Fructus Hordei Germinatus (parched to brown) be 9-10 part, described Jiaoshan Hill Short, bristly hair or beard be 9-10 part, described Fructus Crataegi be 5-6 part, described Semen Raphani be 8-9 part, described Huang Stilbene be 15-16 part, described Flos Caryophylli be 16-18 part, described Semen Myristicae be 11-12 part, described Cortex Magnoliae Officinalis be 12-14 part, the described Radix Aucklandiae be 12-13 part, the described Radix Paeoniae Alba be 12-13 part, described Radix Glycyrrhizae be 4-5 part, described Fructus Jujubae be 5-7 part.
Preferred through layer by layer, there is between each component in compositions more preferable Synergistic and make With, the consumption of each component is more reasonable, to the intestines and stomach without any pessimal stimulation.
The medicine that the compositions of this treatment gastroenteropathy according to present invention offer is prepared from Thing.
It is prepared as medicine by this compositions present invention provided, is not only able to guarantee group The drug effect of compound, but also patient can be facilitated to take.
Preferably, during the dosage form of described medicine includes capsule, tablet, pill or granule Any one.
The medicine that the present invention provides can be capsule, can be tablet, can be pill, It can be granule.These different dosage forms all have good therapeutic effect.But also it is convenient Patient selects according to use habit and the state of an illness.
Except above-mentioned several dosage forms, this compositions that the present invention provides can also be fried into biography The decoction of system.When fried, each component cleaned (all can pulverize), adds each group The water of point gross mass 4-5 times, elder generation's intense fire decocts 0.5-1 hour, then going to slow fire, to decoct 1-1.5 little Time, the filtrate after filtration is decoction.
Decoction has identical drug effect, but is compared to capsule, tablet, pill or granule These dosage forms of agent, decoction is difficult to preserve, and patient can select according to own situation.
Preferably, described medicine also includes pharmaceutically acceptable adjuvant.
Preferably, described pharmaceutically acceptable adjuvant includes wetting agent, binding agent, filling One or more in agent, disintegrating agent, lubricant.
Preferably, described wetting agent includes that distilled water or ethanol, described binding agent include starch One or more in slurry, dextrin, ethyl cellulose, polyvidone or Mel, described filling Agent includes starch, lactose, microcrystalline Cellulose, glucose, mannitol, sucrose or calcium phosphate In one or more；Described disintegrating agent is carboxymethyl starch sodium, cross-linked carboxymethyl cellulose One or more in sodium or polyvinylpolypyrrolidone, described lubricant includes magnesium stearate, Talcum One or more in powder, Polyethylene Glycol or micropowder silica gel.
The preparation method of the compositions of this treatment gastroenteropathy that a kind of present invention provides, bag Include following steps:
Successively through drying, pulverize, mixing after each component being cleaned, obtain the group in the present invention Compound.
In preparation process, each component after pulverizing has a mixed process.Mix is the most equal Even, drug effect is the best.So that can mix more uniform between each component, it is preferable that In the step of described pulverizing, the granularity of pulverizing is not less than 80 mesh.
Compared with prior art, the invention have the benefit that
(1) the invention provides a kind of compositions, said composition working in coordination with by various ingredients Compatibility, when being used for treating gastroenteropathy, is not only able to take stopgap measures, moreover it is possible to effect a permanent cure.
(2) compositions that the present invention provides to the intestines and stomach without pessimal stimulation, can quick acting.Warp Long-term clinical uses checking, takes 1 week and can alleviate the state of an illness, adheres to taking 1-3 month i.e. Can reach the effect taken stopgap measures, make the normal function of the intestines and stomach be recovered.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but this Skilled person is it will be appreciated that the following example is merely to illustrate the present invention, and should not regard For limiting the scope of the present invention.Unreceipted actual conditions person in embodiment, according to normal condition Or the condition of manufacturer's suggestion is carried out.Agents useful for same or instrument unreceipted production firm person, all For the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Weigh Rhizoma Cyperi 5g, Fructus Amomi 4g, Pericarpium Citri Reticulatae 10g, Rhizoma Pinelliae Preparatum 1g, Radix Codonopsis 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 1g, Rhizoma Dioscoreae 2g, Semen Lablab Album 10g, Endothelium Corneum Gigeriae Galli 1g, Massa Medicata Fermentata (parched to brown) 2g, Fructus Hordei Germinatus (parched to brown) 2g, Fructus Crataegi (parched to brown) 2g, Fructus Crataegi 1g, Semen Raphani 1g, Radix Astragali 10g, Flos Caryophylli 10g, Semen Myristicae 4g, Cortex Magnoliae Officinalis 5g, Radix Aucklandiae 5g, Radix Paeoniae Alba 5g, Radix Glycyrrhizae 1g and Fructus Jujubae 2g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, then mix Uniformly, obtain medical treatment the compositions of gastroenteropathy.
With 20Mpa after above-mentioned composition is mixed homogeneously with appropriate lactose and microcrystalline Cellulose Above pressure is pressed into the sheet of diameter 2.5cm, crushes with pulverizer, crosses 18 mesh sieves, Add magnesium stearate mixing tabletting and i.e. obtain tablet.
Embodiment 2
Weigh Rhizoma Cyperi 10g, Fructus Amomi 6g, Pericarpium Citri Reticulatae 12g, Rhizoma Pinelliae Preparatum 6g, Radix Codonopsis 10g, Fu Siberian cocklebur 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 5g, Rhizoma Dioscoreae 10g, Semen Lablab Album 15g, Endothelium Corneum Gigeriae Galli 9g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Hordei Germinatus (parched to brown) 10g, Fructus Crataegi (parched to brown) 10g, Fructus Crataegi 10g, Semen Raphani 10g, Radix Astragali 16g, Flos Caryophylli 10g, Semen Myristicae 5g, Cortex Magnoliae Officinalis 10g, Radix Aucklandiae 10g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 5g, big Fructus Jujubae 5g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, pulverize granulating Degree is the powder of 120 mesh, then mix homogeneously, obtains the treatment the intestines and stomach that the present embodiment provides The compositions of disease.
Above-mentioned composition is added appropriate dextrin mix homogeneously, adds distilled water and prepare soft material, Prepare with granulator and be dried granule, then select No. 3 capsulae vacuus capsule filling machines to prepare glue Wafer.
Embodiment 3
Weigh Rhizoma Cyperi 15g, Fructus Amomi 13g, Pericarpium Citri Reticulatae 30g, Rhizoma Pinelliae Preparatum 5g, Radix Codonopsis 25g, Fu Siberian cocklebur 30g, Rhizoma Atractylodis Macrocephalae (parched with bran) 6g, Rhizoma Dioscoreae 10g, Semen Lablab Album 30g, Endothelium Corneum Gigeriae Galli 9g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Hordei Germinatus (parched to brown) 10g, Fructus Crataegi (parched to brown) 10g, Fructus Crataegi 6g, Semen Raphani 9g, Radix Astragali 25g, Flos Caryophylli 30g, Semen Myristicae 13g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 15g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 5g and Fructus Jujubae 7g.
Above-mentioned each component is cleaned, putting into adds water in marmite carry out fried.The consumption of water is each 4-5 times of component total amount.First the most fried 0.5 hour, then go to slow fire fried 1 Hour.Rear leaching excessively is filtered, and obtains decoction.
Embodiment 4
Weigh Rhizoma Cyperi 10g, Fructus Amomi 10g, Pericarpium Citri Reticulatae 15g, Rhizoma Pinelliae Preparatum 3g, Radix Codonopsis 15g, Fu Siberian cocklebur 15g, Rhizoma Atractylodis Macrocephalae (parched with bran) 3g, Rhizoma Dioscoreae 5g, Semen Lablab Album 15g, Endothelium Corneum Gigeriae Galli 5g, Massa Medicata Fermentata (parched to brown) 7g, Fructus Hordei Germinatus (parched to brown) 7g, Fructus Crataegi (parched to brown) 7g, Fructus Crataegi 3g, Semen Raphani 5g, Radix Astragali 15g, Flos Caryophylli 15g, Semen Myristicae 10g, Cortex Magnoliae Officinalis 10g, Radix Aucklandiae 10g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 3g and Fructus Jujubae 4g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, pulverize granulating Degree is the powder of 100 mesh, then mix homogeneously, obtains the treatment the intestines and stomach that the present embodiment provides The compositions of disease.
Above-mentioned composition is added appropriate dextrin mix homogeneously, adds distilled water and prepare soft material, Prepare with granulator again and be dried granule, obtain granule.
Embodiment 5
Weigh Rhizoma Cyperi 14g, Fructus Amomi 12g, Pericarpium Citri Reticulatae 20g, Rhizoma Pinelliae Preparatum 5g, Radix Codonopsis 20g, Fu Siberian cocklebur 20g, Rhizoma Atractylodis Macrocephalae (parched with bran) 6g, Rhizoma Dioscoreae 10g, Semen Lablab Album 20g, Endothelium Corneum Gigeriae Galli 9g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Hordei Germinatus (parched to brown) 10g, Fructus Crataegi (parched to brown) 10g, Fructus Crataegi 6g, Semen Raphani 9g, Radix Astragali 18g, Flos Caryophylli 20g, Semen Myristicae 12g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 14g, Radix Paeoniae Alba 14g, Radix Glycyrrhizae 5g and Fructus Jujubae 7g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, pulverize granulating Degree is the powder of 120 mesh, then mix homogeneously, obtains the treatment the intestines and stomach that the present embodiment provides The compositions of disease.
Above-mentioned composition is mixed homogeneously with appropriate starch and magnesium stearate, selects No. 3 skies Capsule capsule filling machine prepares capsule.
Embodiment 6
Weigh Rhizoma Cyperi 12g, Fructus Amomi 11g, Pericarpium Citri Reticulatae 18g, Rhizoma Pinelliae Preparatum 4g, Radix Codonopsis 15g, Fu Siberian cocklebur 18g, Rhizoma Atractylodis Macrocephalae (parched with bran) 5g, Rhizoma Dioscoreae 8g, Semen Lablab Album 16g, Endothelium Corneum Gigeriae Galli 8g, Massa Medicata Fermentata (parched to brown) 9g, Fructus Hordei Germinatus (parched to brown) 9g, Fructus Crataegi (parched to brown) 9g, Fructus Crataegi 5g, Semen Raphani 8g, Radix Astragali 15g, Flos Caryophylli 16g, Semen Myristicae 11g, Cortex Magnoliae Officinalis 12g, Radix Aucklandiae 12g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 4g, Fructus Jujubae 5g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, pulverize granulating Degree is the powder of 100 mesh, then mix homogeneously, obtains the treatment the intestines and stomach that the present embodiment provides The compositions of disease.
Above-mentioned composition will add the Mel after refining in right amount, warp and medicine, pill bar, divide Cut round, after sterilization, prepare the pill of 2g specification.
Embodiment 7
Weigh Rhizoma Cyperi 13g, Fructus Amomi 12g, Pericarpium Citri Reticulatae 20g, Rhizoma Pinelliae Preparatum 5g, Radix Codonopsis 16g, Fu Siberian cocklebur 20g, Rhizoma Atractylodis Macrocephalae (parched with bran) 6g, Rhizoma Dioscoreae 10g, Semen Lablab Album 18g, Endothelium Corneum Gigeriae Galli 9g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Hordei Germinatus (parched to brown) 10g, Fructus Crataegi (parched to brown) 10g, Fructus Crataegi 6g, Semen Raphani 9g, Radix Astragali 16g, Flos Caryophylli 18g, Semen Myristicae 12g, Cortex Magnoliae Officinalis 14g, Radix Aucklandiae 13g, Radix Paeoniae Alba 13g, Radix Glycyrrhizae 5g, Fructus Jujubae 7g.
Dry after above-mentioned each component is cleaned, put in pulverizer and pulverize, pulverize granulating Degree is the powder of 100 mesh, then mix homogeneously, obtains the treatment the intestines and stomach that the present embodiment provides The compositions of disease.
Prepare soft material by above-mentioned composition adds appropriate starch, cross 16 mesh sieves and pelletize wet Granule, is dried wet granular in 40-60 DEG C, crosses 16 mesh sieves and pelletizes, and adds Pulvis Talci mixing, Tabletting i.e. obtains tablet.
Clinical practice case:
Liu, man, 32 years old, the frequent pain of upper abdomen occurs for 2014, returns acid, scorching hot, Feel sick, the malaise symptoms such as vomiting, it is diagnosed as chronic gastric ulcer on inspection.Adhere to taking this The medicine (tablet that embodiment 7 prepares) that invention provides.After taking 1 week continuously, pain The phenomenons such as shape disappears, and returns acid, scorching hot, feels sick, vomiting alleviate.After taking 2 months, no Suitable symptom all disappears, and will check, chronic gastric ulcer is easily cured, and does not recurs so far.
Lin, female, 41 years old, within 2015, it is diagnosed as duodenal ulcer.Period ate The medicine that hospital opens, cannot thoroughly cure all the time.Start to take this in June, 2015 The medicine (tablet that embodiment 7 prepares) that invention provides.Fully recover after taking continuously 3 weeks, extremely The present has no recurrence.
Lee, female, 28 years old, start in March, 2014 diarrhoea, after confirm as rectum Scorching.Carrying out enema treatment half a year in hospital, curative effect is inconspicuous.Patient's appetite reduces, body weight Alleviating, complexion is poor.Start in January, 2015 to take the medicine (embodiment that the present invention provides 6 pills prepared), thoroughly to fully recover after treating 2 weeks, appetite also increases, and body weight the most gradually rises Height, complexion slowly improves, and does not recurs so far.
Wang, female, 8 years old, long-term unknown cause loose stool, repeatedly fail to respond to any medical treatment.After take The medicine (tablet that embodiment 7 prepares) that the present invention provides.Cure after 2 weeks, the most not multiple Send out.
Lee, man, 58 years old, long-term gastric acid, flatulence, it is impossible to eat any raw food fruit, food Thing, vomits once eating and suffers from diarrhea, be confirmed to be gastropathy.In many ways seek medical advice and medicine, all cannot Thoroughly cure, diet does not the most note just recur.Rear beginning takes the medicine that the present invention provides Thing (tablet that embodiment 7 provides), thoroughly cures gastropathy after taking continuously 3 months, extremely The present does not recurs.
Zhang, female, 19 years old, functional gastrointestinal disorder, frequent light red tongue was tasteless, and mouth has abnormal flavour. Multi-medicament, DeGrain are eaten.Rear beginning takes the medicine (enforcement that the present invention provides The tablet that example 7 prepares), i.e. cure after taking 20 days continuously, do not recur so far.
Zhao, man, 40 years old, gastric ulcer, have blood in stool.Eat multi-medicament, all cannot be thorough Cure.The rear medicine (pill that embodiment 6 prepares) starting to take present invention offer, continuously The most thoroughly cure after taking 3 months, do not recur so far.
Experimental example 1
This experimental example investigated the present invention provide medicine and conventional Western medicine of the prior art and The Chinese patent medicine of the prior art drug effect in terms for the treatment of chronic gastritis.
Clinical case 184 example, is chronic gastritis.Wherein, male patient 77 example, women Patient 107 example, age distribution is in 22-67 year.
Experimental technique:
The medicine that Example 1-embodiment 7 prepares respectively, takes the circumstances into consideration to take according to conditions of patients, It within 2 weeks, it is a course for the treatment of.
Matched group 1: (manufacturer is for revising the Pharmaceutical group limited public affairs of share for SIDASHU JIAONANG Department), take in accordance with description.
Matched group 2: embodiment 1 preparation in referenced patent application CN103394026A Decoction.Every day, potion, took at twice sooner or later.
Criterion of therapeutical effect is as follows:
Recovery from illness: disease disappears, and gastroscopy inflammation is wholly absent.
Effective: symptom takes a turn for the better, and gastroscopy inflammation disappears substantially.
Effective: symptom takes a turn for the better, and gastroscopy inflammation alleviates.
Invalid: symptom and gastroscopy result are and are obviously improved.
Its result is as shown in table 1:
Table 1 Experimental comparison results
By the above results it can be seen that the medicine that the present invention provides is superior on therapeutic effect Western medicine of the prior art and Chinese patent medicine.
Experimental example 2
This experimental example investigated the present invention provide medicine and conventional Western medicine of the prior art and The Chinese patent medicine of the prior art drug effect in terms for the treatment of chronic enteritis.
Clinical case 244 example, is chronic enteritis.Wherein, male patient 89 example, women Patient 155 example, age distribution is in 17-63 year.
Experimental technique:
The medicine that Example 1-embodiment 7 prepares respectively, takes the circumstances into consideration to take according to conditions of patients, It within 1 week, it is a course for the treatment of.
Matched group 1: norfloxacin capsule (manufacturer be system in Beijing Jing rich pharmacy group) is every Day 2 times, each 4,10 days be a course for the treatment of.
Matched group 2: embodiment 1 preparation in referenced patent application CN101468190A Decoction.Every day potion.
Criterion of therapeutical effect is as follows:
Recovery from illness: clinical symptoms all disappears, and lab testing is normal.
Effective: clinical symptoms takes a turn for the better, and lab testing indices is close to normal level.
Effective: clinical symptom relief, lab testing indices makes moderate progress, and sign has Improve.
Invalid: clinical symptoms is not improved or increases the weight of.
Its result is as shown in table 2:
Table 2 Experimental comparison results
Group Number Recovery from illness Effective Effectively Invalid Total effective rate
Experimental example 1 23 16 2 2 3 87%
Experimental example 2 18 14 1 1 2 89%
Experimental example 3 21 15 1 2 3 86%
Experimental example 4 28 23 1 2 2 93%
Experimental example 5 37 30 2 3 2 95%
Experimental example 6 30 25 2 2 1 97%
Embodiment 7 40 34 3 2 1 98%
Comparative example 1 25 13 4 3 5 80%
Comparative example 2 22 7 3 5 7 68%
By the above results it can be seen that the medicine that the present invention provides is superior on therapeutic effect Western medicine of the prior art and Chinese patent medicine.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that May be made that without departing from the spirit and scope of the present invention many other change and Amendment.It is, therefore, intended that include in the following claims belonging in the scope of the invention All such changes and modifications.

Claims (10)

1. treat gastroenteropathy compositions, it is characterised in that in parts by weight, mainly by Following components is prepared from:
Rhizoma Cyperi 5-15 part, Fructus Amomi 4-13 part, Pericarpium Citri Reticulatae 10-30 part, Rhizoma Pinelliae Preparatum 1-5 part, party Ginseng 10-25 part, Poria 10-30 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 1-6 part, Rhizoma Dioscoreae 2-10 part, the most flat Bean 10-30 part, Endothelium Corneum Gigeriae Galli 1-9 part, Massa Medicata Fermentata (parched to brown) 2-10 part, Fructus Hordei Germinatus (parched to brown) 2-10 part, Jiaoshan Hill Short, bristly hair or beard 2-10 part, Fructus Crataegi 1-6 part, Semen Raphani 1-9 part, Radix Astragali 10-25 part, Flos Caryophylli 10-30 Part, Semen Myristicae 4-13 part, Cortex Magnoliae Officinalis 5-15 part, Radix Aucklandiae 5-15 part, Radix Paeoniae Alba 5-15 part, sweet Grass 1-5 part and Fructus Jujubae 2-7 part.
The compositions for the treatment of gastroenteropathy the most according to claim 1, it is characterised in that Described Rhizoma Cyperi be 10-14 part, described Fructus Amomi be 10-12 part, described Pericarpium Citri Reticulatae be 15-20 part, Described Rhizoma Pinelliae Preparatum be 3-5 part, described Radix Codonopsis be 15-20 part, described Poria be 15-20 part, Described Rhizoma Atractylodis Macrocephalae (parched with bran) be 3-6 part, described Rhizoma Dioscoreae be 5-10 part, described Semen Lablab Album be 15-20 Part, described Endothelium Corneum Gigeriae Galli be 5-9 part, described Massa Medicata Fermentata (parched to brown) be 7-10 part, described Fructus Hordei Germinatus (parched to brown) be 7-10 Part, described Fructus Crataegi (parched to brown) be 7-10 part, described Fructus Crataegi be 3-6 part, described Semen Raphani be 5-9 Part, the described Radix Astragali be 15-18 part, described Flos Caryophylli be 15-20 part, described Semen Myristicae be 10-12 Part, described Cortex Magnoliae Officinalis be 10-15 part, the described Radix Aucklandiae be 10-14 part, the described Radix Paeoniae Alba be 10-14 Part, described Radix Glycyrrhizae be 3-5 part, described Fructus Jujubae be 4-7 part.
The compositions for the treatment of gastroenteropathy the most according to claim 1, it is characterised in that Described Rhizoma Cyperi be 12-13 part, described Fructus Amomi be 11-12 part, described Pericarpium Citri Reticulatae be 18-20 part, Described Rhizoma Pinelliae Preparatum be 4-5 part, described Radix Codonopsis be 15-16 part, described Poria be 18-20 part, Described Rhizoma Atractylodis Macrocephalae (parched with bran) be 5-6 part, described Rhizoma Dioscoreae be 8-10 part, described Semen Lablab Album be 16-18 Part, described Endothelium Corneum Gigeriae Galli be 8-9 part, described Massa Medicata Fermentata (parched to brown) be 9-10 part, described Fructus Hordei Germinatus (parched to brown) be 9-10 Part, described Fructus Crataegi (parched to brown) be 9-10 part, described Fructus Crataegi be 5-6 part, described Semen Raphani be 8-9 Part, the described Radix Astragali be 15-16 part, described Flos Caryophylli be 16-18 part, described Semen Myristicae be 11-12 Part, described Cortex Magnoliae Officinalis be 12-14 part, the described Radix Aucklandiae be 12-13 part, the described Radix Paeoniae Alba be 12-13 Part, described Radix Glycyrrhizae be 4-5 part, described Fructus Jujubae be 5-7 part.
4. treat according to any one of claim 1-3 gastroenteropathy compositions preparation and The medicine become.
Medicine the most according to claim 4, it is characterised in that the dosage form of described medicine Including any one in capsule, tablet, pill or granule.
Medicine the most according to claim 5, it is characterised in that described medicine also includes Pharmaceutically acceptable adjuvant.
Medicine the most according to claim 6, it is characterised in that described pharmaceutically can connect The adjuvant being subject to includes the one in wetting agent, binding agent, filler, disintegrating agent, lubricant Or it is multiple.
Medicine the most according to claim 7, it is characterised in that described wetting agent includes Distilled water or ethanol, described binding agent includes starch slurry, dextrin, ethyl cellulose, poly-dimension One or more in ketone or Mel, described filler includes starch, lactose, microcrystalline cellulose One or more in element, glucose, mannitol, sucrose or calcium phosphate；Described disintegrating agent For the one in carboxymethyl starch sodium, cross-linking sodium carboxymethyl cellulose or polyvinylpolypyrrolidone or many Kind, described lubricant includes in magnesium stearate, Pulvis Talci, Polyethylene Glycol or micropowder silica gel One or more.
9. described in an any one of claim 1-3, treat the preparation of the compositions of gastroenteropathy Method, it is characterised in that comprise the steps:
Successively through drying, pulverize, mixing after each component being cleaned, obtain the group in the present invention Compound.
Preparation method the most according to claim 9, it is characterised in that described pulverizing Step in, the granularity of pulverizing is not less than 80 mesh.
CN201610173481.5A 2016-03-24 2016-03-24 Composition for treating gastrointestinal diseases, preparation method thereof and medicine made from composition Pending CN105727139A (en)

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CN112494551A (en) * 2020-12-02 2021-03-16 建昌帮药业有限公司 Traditional Chinese medicine composition for conditioning gastrointestinal functions of middle-aged and elderly people and preparation method thereof
CN112807401A (en) * 2021-02-22 2021-05-18 周鹏 Traditional Chinese medicine formula for treating gastrointestinal diseases

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CN101983702A (en) * 2010-11-16 2011-03-09 西安融慧专利产品开发咨询有限责任公司 Traditional Chinese medicine composition for treating stomach deficiency and preparation method thereof
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