CN112494551A

CN112494551A - Traditional Chinese medicine composition for conditioning gastrointestinal functions of middle-aged and elderly people and preparation method thereof

Info

Publication number: CN112494551A
Application number: CN202011404643.4A
Authority: CN
Inventors: 岳玉荣; 易斌; 韩雅慧; 钟敏; 龚旭; 张李丹; 郭文霞; 侯彦爽
Original assignee: Jianchangbang Pharmacy Co ltd
Current assignee: Jianchangbang Pharmacy Co ltd
Priority date: 2020-12-02
Filing date: 2020-12-02
Publication date: 2021-03-16

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for conditioning gastrointestinal functions of middle-aged and elderly people and a preparation method thereof. According to the invention, the body of middle-aged and elderly people is conditioned by using astragalus, bighead atractylodes rhizome, endothelium corneum gigeriae galli, Chinese date, donkey-hide gelatin, caulis spatholobi, white hyacinth bean and fructus amomi, Chinese herbal medicines and folic acid derivatives are compounded, folic acid is wrapped by Chinese herbal medicine plant fibers, and proper Chinese herbal medicine matching and dosage proportion are adopted, so that folic acid is not excessively absorbed or can not be released due to serious wrapping in the process of reaching the microenvironment of large intestine.

Description

Traditional Chinese medicine composition for conditioning gastrointestinal functions of middle-aged and elderly people and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for conditioning gastrointestinal functions of middle-aged and elderly people and a preparation method thereof.

Background

With the increase of age, various functions of a human body are in a degeneration trend, the middle-aged and old people are often constipation due to gradual decline of gastrointestinal functions and weakened enterokinesia, and the constipation is also a common disease and frequently-occurring accompanying symptom of old people such as hypertension, coronary heart disease, hyperlipidemia, diabetes, cerebral apoplexy and the like, and the constipation and the diseases are mutually influenced to cause vicious circle.

The commonly used traditional Chinese medicine for intestine and stomach health care is generally prepared by combining a plurality of medicinal materials and auxiliary materials, for example, a 'xiangguojiangxiao tablet' is prepared by compounding valeriana jatamansi, vanilla, costustoot, sticky rice, dextrin, starch, magnesium stearate and white sugar; the "big haw pill" is made up by using haw, medicated leaven, malt and honey through a certain preparation process. The Chinese patent medicine is beneficial to appetizing and digesting, can relieve stomach discomfort and adverse symptoms, has certain curative effect, but has limited effect on middle-aged and elderly people, improves symptoms during taking, is easy to relapse after stopping taking, forms dependence on medicines, and reduces curative effect and causes burden on intestines and stomach after continuous taking for too long time.

Chinese patent application CN110236034A discloses a Chinese herbal medicine composition for regulating intestines and stomach, belonging to the technical field of Chinese herbal medicine composition food and health food. The Chinese herbal medicine composition comprises an orange peel extract, a dried ginger extract, a fructus amomi extract, a sea buckthorn extract, a lily extract, a red date extract, a longan extract, a hawthorn extract, a mulberry extract and an angelica dahurica extract. The Chinese herbal medicine composition is an edible Chinese herbal medicine food composition or health-care food, is used for conditioning intestines and stomach, is beneficial to balancing digestive system, conditioning intestines and stomach and recovering spleen and stomach functions, and is suitable for office workers, people with frequent improper intestines and stomach, consumers with irregular diet and the like.

Chinese patent application CN108355101A discloses a traditional Chinese medicine composition for coordinating intestines and stomach, which comprises radix codonopsitis, cyperus rotundus, fructus amomi, rhizoma atractylodis macrocephalae, rhizoma atractylodis, charred triplet, pericarpium citri reticulatae viride, oyster and rangooncreeper fruit. The traditional Chinese medicine composition for coordinating intestines and stomach provided by the invention is reasonable in compatibility of components, safe, reliable and free of side effect; the traditional Chinese medicine composition is mild in medicine property, can effectively dispel cold qi of a human body and enhance body resistance, has a good treatment effect on stomach cold type stomach diseases, dyspepsia and intestinal hernia, and has an effective rate of 95.2%.

Chinese patent application CN111150824A discloses a traditional Chinese medicine composition for coordinating intestines and stomach, which comprises 50-80 parts of clove, 25-45 parts of honeysuckle, 20-35 parts of liquorice, 10-15 parts of gordon euryale seed, 12-15 parts of bighead atractylodes rhizome, 20-30 parts of astragalus, 15-18 parts of Chinese yam, 12-16 parts of hawthorn, 18-20 parts of dried ginger, 12-15 parts of poria cocos, 15-17 parts of adenophora stricta and 10-12 parts of polygonatum odoratum; the invention also discloses a preparation method of the traditional Chinese medicine composition for coordinating intestines and stomach, which comprises the following steps: (1) preparing medicines: the medicines are weighed according to the proportion. Cleaning with clear water for later use; (2) respectively crushing the raw materials, sieving with 80 mesh sieve, and filtering to obtain unqualified medicinal powder; (3) the medicinal powder is filled into tea bag, and the tea bag is soaked in boiling water for 15-20min for drinking. The traditional Chinese medicine composition for conditioning intestines and stomach can condition the intestines and stomach and relieve discomfort symptoms of gastrointestinal dysfunction.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide the traditional Chinese medicine composition which can regulate intestines and stomach and is suitable for middle-aged and elderly people and diabetic patients.

A traditional Chinese medicine composition for coordinating intestines and stomach comprises the following components in parts by weight:

astragalus root, white atractylodes rhizome, chicken's gizzard-membrane, Chinese date, donkey-hide gelatin, spatholobus stem, white hyacinth bean, folic acid compounds, amomum fruit and xylo-oligosaccharide.

Further, the traditional Chinese medicine composition comprises the following components in parts by weight:

25-35 parts of astragalus membranaceus, 12-18 parts of bighead atractylodes rhizome, 5-7 parts of endothelium corneum gigeriae galli, 8-12 parts of Chinese date, 6-15 parts of donkey-hide gelatin, 5-7 parts of caulis spatholobi, 3-6 parts of white hyacinth beans, 0.05-0.2 part of folic acid compounds, 3-6 parts of fructus amomi and 1-5 parts of xylo-oligosaccharide.

The folic acid compound is one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances capable of metabolizing and/or generating folic acid in vivo.

Further, the folic acid compounds are at least one of folic acid, leucovorin and L-methyl folic acid.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

respectively weighing radix astragali, Atractylodis rhizoma, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, mixing, adding folic acid compounds and xylooligosaccharide, mixing, stirring, and grinding to 20-60 mesh.

The raw materials of the composition also comprise a pharmaceutically acceptable carrier or excipient and edible essence, wherein the pharmaceutically acceptable carrier or excipient is selected from one or more of starch, magnesium stearate, microcrystalline cellulose xylitol, sorbitol, isomalt, isomaltulose and maltitol.

A preparation of the traditional Chinese medicine composition is in a dosage form of one of tablets, capsules, granules, pills and powder.

The application of the traditional Chinese medicine composition is to prepare a product for regulating the gastrointestinal function of middle-aged and elderly people.

Astragalus root: the smell is slightly sweet, and the chewing taste is slightly beany. Sweet and warm. It enters lung and spleen meridians. Tonify qi, strengthen superficies, induce diuresis, expel pus, heal wound and promote tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): the body has the function of excess exterior and is not used by the patients with exterior evil; can help qi, and is not used for people with excessive qi; can be used for treating internal obstruction, deficiency, obstruction of chest and diaphragm, and stagnation of intestine and stomach; it is contraindicated for yang excess and yin deficiency; it is contraindicated for the cases with excessive heat in the upper energizer and deficiency-cold in the lower energizer; patients are angry and liver qi disharmony is avoided; it is contraindicated for acne with hot blood.

White atractylodes rhizome: atractylodis rhizoma is rhizome of perennial herb of Compositae, and has effects of invigorating qi and spleen, eliminating dampness and promoting diuresis. Modern researches show that the medicine can show obvious and lasting diuretic effect, can promote the discharge of electrolytes, especially sodium, and does not influence the antidiuretic effect of posterior pituitary hormone, so that the action mechanism of the medicine is probably to excrete Na^﹢、Cl^﹣Action, in addition, increased CO content in urine, increased pH and increased K^﹢Excretion, reduction of NH^﹢The feature of excretion. The single white atractylodes rhizome can obviously increase TH cells, improve the TH/TS ratio, correct the distribution disorder state of T cell subsets, obviously improve the low IL-2 level and increase the expression of IL-2R on the surface of T lymphocytes. The atractylodes macrocephala koidz can improve immunity, prolong the service life of lymphocytes and enhance the capability of organism in removing free radicals, and has obvious antioxidation.

Endothelium corneum gigeriae galli: sweet and neutral. It enters spleen, stomach, small intestine and bladder meridians. Modern pharmacological studies show that the endothelium corneum gigeriae galli has the effects of removing food stagnation, strengthening spleen and stomach and the like.

White hyacinth bean: sweet and warm. It enters spleen and stomach meridians. Modern pharmacological research shows that the white hyacinth bean has the functions of improving the immunologic function, resisting bacteria, viruses, tumors, oxidation, blood sugar and cholesterol and the like.

E, donkey-hide gelatin: sweet in nature, neutral in nature, entering lung, liver and kidney meridians, and has the effects of enriching blood, nourishing yin, moistening lung and stopping bleeding. Donkey-hide gelatin is an emotional product of blood and meat, is sweet, mild and moist, is an essential blood-enriching drug, is mostly used for blood deficiency symptoms, and has the function of stopping bleeding, so the donkey-hide gelatin has a good effect on blood deficiency caused by bleeding. Modern pharmacological research shows that the donkey-hide gelatin has obvious blood enriching effect, promotes the hematopoietic function, improves the immunity of the organism, and improves the anoxia resistance and fatigue resistance.

Caulis spatholobi: bitter in property, slightly sweet and warm in property, entering liver and meridian, with the functions of promoting qi and blood circulation, regulating menstruation, relaxing tendons and activating collaterals. "materia Medica" Japanese Shi Yi: its vine has the best effect of promoting blood circulation, warming waist and knees and treating paralysis. Research shows that the traditional Chinese medicine caulis spatholobi monomer SS8 has obvious stimulation effect on the proliferation of hematopoietic progenitor cells (CFU-M, CFU-E, BFU-E and CFU-me) of a marrow suppression mouse, and has certain time and dosage correlation. Researches show that the caulis Spatholobi extract has a function of inhibiting the spectral growth of tumor cell lines in vitro, and flavonoids may be an effective anti-tumor component.

Amomum fruit: pungent taste and warm nature, entering spleen and stomach meridians; has effects in eliminating dampness, promoting qi circulation, warming middle warmer, and preventing miscarriage; can be used for treating stagnation of qi due to damp obstruction, abdominal distention and pain, anorexia, diarrhea due to cold-dampness, pernicious vomiting, and threatened abortion.

Chinese date: sweet and warm. It enters spleen, stomach and heart meridians. Tonify middle-jiao and Qi, nourish blood and soothe the nerves. It can be used for treating spleen deficiency, anorexia, asthenia, and loose stool.

The invention has the beneficial technical effects that:

(1) treating various chronic gastrointestinal diseases such as constipation, abdominal distention and pain, chronic gastritis, bile reflux gastritis, etc.

(2) The body constitution of the middle-aged and the elderly people is optimized and reasonably proportioned; it is safe and has no adverse side effects, and can be taken by patients with diabetes and hypertension.

(3) The invention utilizes the regulation effect of folic acid on intestinal flora and the characteristic of unabsorbed plant fibers in the traditional Chinese medicinal materials, reduces the absorption of folic acid in small intestine by wrapping the plant fibers, and changes the concentration of folic acid in large intestine after the folic acid is brought to duodenum, thereby regulating the intestinal flora and relieving the symptom of gastrointestinal discomfort.

(4) The reasonable compounding of the traditional Chinese medicine composition and the folic acid provided by the invention ensures that the folic acid is not absorbed too much by small intestines but is transported to large intestines, so that the intestinal microenvironment is adjusted while the body is conditioned, the intestinal function is adjusted, and meanwhile, safe traditional Chinese medicinal materials are adopted for conditioning the body conditions of middle-aged and elderly people, so that the application range is wide.

Detailed Description

Example 1

Traditional Chinese medicine composition for coordinating intestines and stomach

25 parts of astragalus membranaceus, 18 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of folic acid and 1 part of xylo-oligosaccharide.

Respectively weighing radix astragali, rhizoma Atractylodis Macrocephalae, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, adding folic acid and xylooligosaccharide, mixing, stirring, and grinding to 60 mesh.

Example 2

35 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 5 parts of caulis spatholobi, 7 parts of endothelium corneum gigeriae galli, 8 parts of Chinese date, 15 parts of donkey-hide gelatin, 3 parts of white hyacinth bean, 3 parts of fructus amomi, 0.1 part of folic acid and 5 parts of xylo-oligosaccharide.

Respectively weighing radix astragali, rhizoma Atractylodis Macrocephalae, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, adding folic acid and xylooligosaccharide, mixing, stirring, and grinding to 20 mesh.

Example 3

30 parts of astragalus membranaceus, 12 parts of bighead atractylodes rhizome, 7 parts of caulis spatholobi, 6 parts of endothelium corneum gigeriae galli, 10 parts of Chinese date, 6 parts of donkey-hide gelatin, 6 parts of white hyacinth bean, 5 parts of fructus amomi, 0.05 part of folic acid and 3 parts of xylo-oligosaccharide.

Respectively weighing radix astragali, rhizoma Atractylodis Macrocephalae, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, adding folic acid and xylooligosaccharide, mixing, stirring, and grinding to 40 mesh.

Example 4

25 parts of astragalus membranaceus, 18 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of leucovorin and 1 part of xylo-oligosaccharide.

Respectively weighing radix astragali, rhizoma Atractylodis Macrocephalae, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, adding leucovorin and xylooligosaccharide, mixing, stirring, and grinding to 60 mesh.

Example 5

25 parts of astragalus membranaceus, 18 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of L-methyl folic acid and 1 part of xylo-oligosaccharide.

Respectively weighing radix astragali, rhizoma Atractylodis Macrocephalae, endothelium corneum Gigeriae Galli, fructus Jujubae, caulis Spatholobi, semen lablab album and fructus Amomi according to weight parts, pulverizing the above Chinese medicinal materials, adding L-methylfolic acid and xylooligosaccharide, mixing, stirring, and grinding to 60 mesh.

Comparative example 1-less fiber of Chinese medicinal plant

15 parts of astragalus membranaceus, 10 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of folic acid and 1 part of xylo-oligosaccharide.

Comparative example 2 more plant fiber of traditional Chinese medicine

40 parts of astragalus membranaceus, 25 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of folic acid and 1 part of xylo-oligosaccharide.

Comparative example 3-No Folic acid or Folic acid derivatives

25 parts of astragalus membranaceus, 18 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of fructus amomi and 1 part of xylo-oligosaccharide.

Comparative example 4 replacement of Astragalus membranaceus and Atractylodes macrocephala

25 parts of ginseng, 18 parts of liquorice, 6 parts of suberect spatholobus stem, 5 parts of chicken's gizzard-membrane, 12 parts of Chinese date, 10 parts of donkey-hide gelatin, 4 parts of white hyacinth bean, 6 parts of villous amomum fruit, 0.2 part of folic acid and 1 part of xylo-oligosaccharide.

Comparative example 5 replacement of fructus Jujubae and colla Corii Asini

25 parts of astragalus membranaceus, 18 parts of bighead atractylodes rhizome, 6 parts of caulis spatholobi, 5 parts of endothelium corneum gigeriae galli, 12 parts of ligusticum wallichii, 10 parts of angelica sinensis, 4 parts of white hyacinth bean, 6 parts of fructus amomi, 0.2 part of folic acid and 1 part of xylo-oligosaccharide.

Effect example-evaluation of defecation promoting Effect (reference to health food test and evaluation technical Specification (2003 edition))

1. Experimental animals, healthy male clean-grade Kunming mice, body weight (20 + -2) g.

2. The experiment groups are divided into a normal control group, a constipation model group, 5 groups of examples 1-5 and a comparative example 1-3, each group contains 5 mice, and the mice are subjected to intragastric administration at fixed time every day.

The normal control group and the constipation model group are infused with distilled water with equal amount;

the corresponding compositions were gavage administered in groups 1-5 and comparative groups 1-3 at 0.05mg folic acid per unit, whereas comparative example 3 contained no folic acid, so the gavage of the composition of comparative example 3 remained the same as example 1 except folic acid.

The gavage treatment was carried out for 10 days, and the mice in the experimental group were fed with free water within 10 days.

3. Mice in each group were fasted for 16 hours without water deprivation. The normal control group was given distilled water, the constipation model group and the groups of examples 1-5, and the groups of comparative examples 1-3 were given compound diphenoxylate (10mg/Kg BW) by gavage.

4. After administering compound diphenoxylate for 0.5 hour, mice in normal control group and constipation model group were gavaged with ink, and the corresponding compositions were gavaged in examples 1-5 and comparative examples 1-3 at 0.05 mg/folic acid compound, wherein comparative example 3 did not contain folic acid compound, so that the gavage amount of the composition in comparative example 3 was identical to that in example 1 except folic acid compound. All mice were fed with normal drinking water.

5. Starting from the ink filling, the time for discharging black feces of the first grain of each animal, the number of the discharged black feces in 6 hours and the weight of the discharged black feces are recorded.

The results are shown in Table 1.

TABLE 1 defecation of mice of different groups

P <0.05, P <0.01, compared to model group.

According to the invention, a plurality of traditional Chinese medicines are utilized to condition the bodies of middle-aged and elderly people, the traditional Chinese medicines are reasonably matched, meanwhile, the traditional Chinese medicines and folic acid derivatives are compounded, the folic acid is wrapped by the plant fibers of the traditional Chinese medicines, and proper traditional Chinese medicine matching and dosage proportion are adopted, so that the folic acid cannot be absorbed too much or cannot be released due to serious wrapping in the process of reaching the microenvironment of the large intestine.

Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A traditional Chinese medicine composition for coordinating intestines and stomach comprises the following components in parts by weight:

2. The composition according to claim 1, which comprises the following components in parts by weight:

3. The composition of claim 1, wherein the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances capable of metabolizing and/or generating folic acid in vivo.

4. The composition of claim 1, wherein the folic acid compounds are at least one of folic acid, leucovorin, and L-methylfolic acid.

5. The composition according to claim 1, wherein the raw materials of the composition further comprise a pharmaceutically acceptable carrier or excipient and a flavoring essence.

6. The composition according to claim 5, wherein the pharmaceutically acceptable carrier or excipient is selected from one or more of starch, magnesium stearate, microcrystalline cellulose xylitol, sorbitol, isomalt, isomaltulose and maltitol.

7. A method for preparing the Chinese medicinal composition as claimed in any one of claims 1 to 6,

weighing the components except the folic acid compounds and the xylo-oligosaccharide according to the weight parts respectively, crushing, mixing, adding the folic acid compounds and the xylo-oligosaccharide, uniformly mixing, and grinding to 20-60 meshes to obtain the product.

8. A formulation of the Chinese medicinal composition of any one of claims 1-6, which is a solid formulation.

9. The formulation of claim 8, wherein the dosage form is one of a tablet, a capsule, a granule, a pill, and a powder.

10. The use of a Chinese medicinal composition as claimed in any one of claims 1 to 6 in the preparation of a product for regulating gastrointestinal function in the elderly.