CN104666658A - Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition Download PDFInfo
- Publication number
- CN104666658A CN104666658A CN201510130068.6A CN201510130068A CN104666658A CN 104666658 A CN104666658 A CN 104666658A CN 201510130068 A CN201510130068 A CN 201510130068A CN 104666658 A CN104666658 A CN 104666658A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- preparation
- ostalgia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 95
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 201000008968 osteosarcoma Diseases 0.000 title claims abstract description 23
- 239000000203 mixture Substances 0.000 title claims abstract description 10
- 206010028980 Neoplasm Diseases 0.000 title abstract description 8
- 206010027476 Metastases Diseases 0.000 title abstract 4
- 208000035269 cancer or benign tumor Diseases 0.000 title abstract 4
- 230000009401 metastasis Effects 0.000 title abstract 4
- 238000011282 treatment Methods 0.000 claims abstract description 14
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 12
- 241000218176 Corydalis Species 0.000 claims abstract description 12
- 241001489978 Eupolyphaga Species 0.000 claims abstract description 12
- 239000004863 Frankincense Substances 0.000 claims abstract description 12
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims description 26
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 21
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 17
- 239000008187 granular material Substances 0.000 claims description 14
- 241000756943 Codonopsis Species 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 239000003826 tablet Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 9
- 241000007126 Codonopsis pilosula Species 0.000 abstract description 7
- 240000001398 Typha domingensis Species 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 210000003608 fece Anatomy 0.000 abstract description 7
- 244000237330 gutta percha tree Species 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000301400 Trogopterus Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 26
- 210000000952 spleen Anatomy 0.000 description 14
- 210000004185 liver Anatomy 0.000 description 12
- 235000009508 confectionery Nutrition 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 241000092665 Atractylodes macrocephala Species 0.000 description 6
- 241001608538 Boswellia Species 0.000 description 6
- 235000018062 Boswellia Nutrition 0.000 description 6
- 241000282461 Canis lupus Species 0.000 description 6
- 241000131329 Carabidae Species 0.000 description 6
- 241000830532 Corydalis yanhusuo Species 0.000 description 6
- 244000197580 Poria cocos Species 0.000 description 6
- 235000008599 Poria cocos Nutrition 0.000 description 6
- 241000405911 Rehmannia glutinosa Species 0.000 description 6
- 241000304195 Salvia miltiorrhiza Species 0.000 description 6
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 235000004224 Typha angustifolia Nutrition 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 3
- 206010008342 Cervix carcinoma Diseases 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 208000019255 Menstrual disease Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 3
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
- 206010033128 Ovarian cancer Diseases 0.000 description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 206010038389 Renal cancer Diseases 0.000 description 3
- 208000006265 Renal cell carcinoma Diseases 0.000 description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 description 3
- 208000033781 Thyroid carcinoma Diseases 0.000 description 3
- 208000024770 Thyroid neoplasm Diseases 0.000 description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 3
- 239000000605 aspartame Substances 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
- 235000010357 aspartame Nutrition 0.000 description 3
- 229960003438 aspartame Drugs 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 201000008275 breast carcinoma Diseases 0.000 description 3
- 201000010881 cervical cancer Diseases 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000005619 esophageal carcinoma Diseases 0.000 description 3
- 206010017758 gastric cancer Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 201000010174 renal carcinoma Diseases 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 201000011549 stomach cancer Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 201000002510 thyroid cancer Diseases 0.000 description 3
- 208000013077 thyroid gland carcinoma Diseases 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 206010006002 Bone pain Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 208000012886 Vertigo Diseases 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000002567 autonomic effect Effects 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 231100000889 vertigo Toxicity 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- WGYQMUUOJZKKDJ-UHFFFAOYSA-M C(CCC(=O)O)(=O)O.C(CCCCCCCCCCCCCCC)S[Na] Chemical compound C(CCC(=O)O)(=O)O.C(CCCCCCCCCCCCCCC)S[Na] WGYQMUUOJZKKDJ-UHFFFAOYSA-M 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010027452 Metastases to bone Diseases 0.000 description 1
- 206010027458 Metastases to lung Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 240000002825 Solanum vestissimum Species 0.000 description 1
- 235000018259 Solanum vestissimum Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 206010042170 Strangury Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 208000024851 esophageal melanoma Diseases 0.000 description 1
- 201000005621 esophagus lymphoma Diseases 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 210000002758 humerus Anatomy 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000003689 pubic bone Anatomy 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-15 parts of codonopsis pilosula, 10-15 parts of poria, 15-20 parts of raw rhizoma atractylodis macrocephalae, 15-30 parts of radix rehmanniae preparata, 10-15 parts of eucommia ulmoides, 15-20 parts of glossy privet fruit, 15-30 parts of salviae miltiorrhizae, 10-12 parts of olibanum, 10-15 parts of cattail pollen, 10-15 parts of trogopterus dung, 8-10 parts of eupolyphaga, 15-30 parts of white paeony root, 15-30 parts of rhizoma corydalis and 5-15 parts of honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, is free of a toxic or side effect, convenient to process, low in cost, and obvious in treatment effect on osteosarcoma ostalgia and bone metastasis neoplasm. The invention further discloses a preparation method of the traditional Chinese medicine composition and a medicine prepared from the traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia.
Description
Technical field
The invention belongs to modern Chinese traditional medicine field, relate to a kind of treat osteosarcoma osteodynia and metastatic tumor of bone osteodynia Chinese prescription and application in the medicine of preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia.
Background technology
Osteosarcoma is one of common malignant tumor of teenager, and send out well the age between 3-25 year, the multiple long bone being born in human body, sees femur at most.Osteosarcomatous main clinical manifestation is: local pain and swelling, and pain is persistence severe pain, is difficult to stand, bone and arthralgia or swelling, and night increases the weight of, and whole body is with heating, weight loss, fatigue and mobility decline simultaneously.Disease progression is rapid, and grade malignancy is high, often Lung metastases occurs in early days and occurs the symptoms such as cough, spitting of blood.
Metastatic tumor of bone refers to other organs tumor, is transferred to the tumor of osseous tissue by the multiple channel such as blood or lymph.The modal primary tumo(u)r of metastatic tumor of bone is breast carcinoma, pulmonary carcinoma, thyroid carcinoma and renal carcinoma, and other have nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma and lymphoma etc.All can there is metastatic tumor in the bone of whole body, but common with rib, vertebrae, ilium, pubis, humerus, femur and skull etc. clinically.The modal symptom of metastatic tumor of bone is local pain.Also can there is pathologisch Bruch and subside or the outer extensive diffusive of bone and cause the neurological symptom caused by corresponding spinal cord, cranial nerve and peripheral nerve pressurized due to osteoclasia.
The symptom that metastatic tumor of bone and osteosarcoma also have some identical.Bone tumor and pernicious metastatic tumor of bone develop very fast because of it, often merge General Symptoms, and as weak, anemia, malnutrition, even cachexia, visible local pain and tenderness, normal and lump occurs simultaneously or first occurs.Start pain slightly in intermittent dull pain, then become persistence and to give a farfetched interpretation sample severe pain, make us unbearably, especially to attach most importance to night.
For the treatment of osteosarcoma and metastatic tumor of bone, often first-selected operation, but because postoperative recurrence needs row second operation, also may occur recurrence and transfer in addition, therefore Most patients and relatives are unwilling to accept this reality.Chemotherapy is owing to directly suppressing bone marrow hematogenesis function, and the leukocyte of patient reduces rapidly, and body constitution obviously weakens, and makes treatment have to interrupt.From traditional medicine, find active active drug that is strong, that have no side effect become the new way solving this problem.
Summary of the invention
The object of the present invention is to provide a kind of Be very effective, have no side effect, medication is convenient, treatment osteosarcoma osteodynia with low cost and the medicine of metastatic tumor of bone osteodynia.
For achieving the above object, the present invention takes following technical scheme:
The invention provides a kind of Chinese prescription for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia, described Chinese prescription is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 10-15 part, Poria (Poria cocos (Schw.) Wolf) 10-15 part, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15-20 part, Radix Rehmanniae Preparata (Rehmannia glutinosa) 15-30 part, the Cortex Eucommiae (Eucommia ulmoides) 10-15 part, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15-20 part, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 15-30 part, Olibanum (Boswellia carterii Birdw.) 10-12 part, Pollen Typhae (Typha angustifolia L.) 10-15 part, Oletum Trogopterori (Faeces Trogopterori) 10-15 part, eupolyphaga (ground beetle) 8-10 part, the Radix Paeoniae Alba (Radix Paeoniae Alba) 15-30 part, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 15-30 part, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 5-15 part.
Preferably, a kind of Chinese prescription for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia provided by the invention is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 20 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
Chinese medicine of the present invention according to traditional medicine and modern medical analysis, the property of medicine and pharmacological action as follows:
Radix Codonopsis: sweet in the mouth, property is put down.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI; For diseases such as deficiency of vital energy deficiency, fatigue and weakness, dyspnea with rapid breath, insufficiency of the spleen lack of appetite, the edema of the face, chronic diarrhea proctoptosis.
Poria: slightly sweet flavor, property are flat; Gui Jing: GUIXIN, lung, spleen channel; Function cures mainly: spleen invigorating, calm the nerves, calm, diuresis, also can promote body immune ability.
Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement for insufficiency of the spleen lack of appetite, abdominal distention.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, and night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, vertigo and tinnitus, early whitening of beard and hair.
The Cortex Eucommiae: nature and flavor are sweet, temperature; Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Fructus Ligustri Lucidi: nature and flavor are sweet, bitter, cool; Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, improving eyesight, clearind deficient heat.
Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Function cures mainly: obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, and abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Olibanum: nature and flavor are pungent, bitter, temperature; GUIXIN, liver, spleen channel.Function cures mainly: obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, and lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.
Pollen Typhae: nature and flavor are sweet, flat; Return liver, pericardium channel.Function cures mainly: spit blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, and amenorrhea stimulates the menstrual flow, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Oletum Trogopterori: nature and flavor are bitter, sweet, warm; Return Liver Channel.Function cures mainly: function cures mainly: amenorrhea, dysmenorrhea, postpartum stagnation, breast abdomen pain, metrorrhagia, menorrhagia.
Eupolyphaga: nature and flavor are salty, cold, slightly poisonous; Return Liver Channel.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
The Radix Paeoniae Alba: bitter, acid, to be slightly cold; Return liver, spleen channel.Function cures mainly: menoxenia, metrorrhagia, sweating due to debility, gastral cavity abdomen shoot, the pain over the hypochondriac region, limb pain twin, headache are dizzy.
Rhizoma Corydalis: pungent, bitter, temperature; Return liver, spleen channel.Function cures mainly: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Glycyrrhizae Preparata: taste is sweet, flat; GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Present invention also offers a kind of pharmaceutical preparation for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia, the effective ingredient of described pharmaceutical preparation is prepared from according to pharmaceutical preparation customary preparation methods by above-mentioned Chinese prescription.In specific embodiment of the invention scheme, the effective ingredient of described pharmaceutical preparation is prepared by the following method: (1) prepares above-mentioned Chinese prescription; (2) above-mentioned Chinese prescription is concentrated into paste; (3) by extractum prepared by step (2), pharmaceutics conventional formulation technique is adopted to be prepared into various dosage form.
Further, said medicine preparation also comprises pharmaceutically conventional adjuvant, and described adjuvant can be lubricant, filler, disintegrating agent, correctives.Filler is selected from one or more in lactose, microcrystalline cellulose, sucrose, sorbitol, mannitol, starch, pregelatinized Starch; Disintegrating agent is selected from one or more in hydroxypropyl cellulose, Sodium Hydroxymethyl Stalcs, sodium carboxymethyl cellulose, sodium lauryl sulphate, Hexadecvlthio sodium succinate, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium dioctyl sulfosuccinate; Lubricant is selected from one or more in Stepanol MG, silicon dioxide, Pulvis Talci, stearic acid, magnesium stearate, calcium stearate; Correctives includes but not limited to sucrose, polyhydric alcohol, glycerol, aspartame, cyclamate, stevioside.
Further, the dosage form of described pharmaceutical preparation is the conventional oral dosage formulations on pharmaceutics.Described peroral dosage form can be oral liquid, granule, pill, tablet, capsule.
The invention provides a kind of preparation method of above-mentioned Chinese prescription, the concrete steps of described preparation method are as follows:
(1) get it filled by above-mentioned raw material of Chinese medicine proportioning, clear water soaks;
(2) medicament mixed through soaking is put into drug-decocting appliance and decoct twice, first time adds 3 times amount soak by water and filters, and second time adds 2 times amount soak by water and filters;
(3) twice decoction liquor is merged, needed for gained Chinese medicine extract is.
Further, the concrete steps of the preparation method of above-mentioned Chinese prescription are as follows:
(1) get it filled by above-mentioned raw material of Chinese medicine proportioning, clear water soaks 6-10h;
(2) medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1-3h and filters, and second time adds 2 times amount soak by water 0.5-1.5h and filters;
(3) twice decoction liquor is merged, needed for the Chinese medicine extract of acquisition is.
In specific embodiment of the invention scheme, the concrete operation step of bolus of drug preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) ball is made by extractum group prepared by step (2), obtain pill.
In specific embodiment of the invention scheme, the concrete operation step of medicinal granule preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) extractum prepared by step (2) is added the starch of raw material of Chinese medicine total amount 1/10 weight portion, the sucrose of 1/10 weight portion, make granule; Or add the dextrin of raw material of Chinese medicine total amount 1/5 weight portion, make granule; Or add the aspartame of the starch of raw material of Chinese medicine total amount 1/5 weight portion, 1/2000 weight portion, make granule.
In specific embodiment of the invention scheme, the concrete operation step of medicine capsule preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extract dry prepared by step (2), pulverize and sieve, incapsulate shell, capsule.
In specific embodiment of the invention scheme, the concrete operation step of medicinal tablet preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) extractum prepared by step (2) is added the starch mixing of raw material of Chinese medicine total amount 1/5 weight portion, make granule, dry, tabletting, makes tablet.
In specific embodiment of the invention scheme, the concrete operation step of drug oral liquid and preparation method thereof is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) extracting solution prepared by step (1) is concentrated into original 1/20, cold preservation, gets supernatant and is again concentrated into 2/3, cold preservation, centrifugal, the sucrose that centrifugal liquid adds raw material of Chinese medicine total amount 1/5 weight portion boils dosing, bottling, sealing sterilizing, obtained oral liquid.
Present invention also offers the application of above-mentioned Chinese prescription in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
Present invention also offers the application of said medicine preparation in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
Pharmaceutical preparation the present invention prepared is applied to osteosarcoma osteodynia patient, metastatic tumor of bone patient, detects therapeutic effect.Pharmaceutical preparation consumption: patient often takes the pharmaceutical preparation be equivalent to containing Radix Codonopsis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rehmanniae Preparata 20g, Cortex Eucommiae 12g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 30g, Olibanum 10g, Pollen Typhae 10g, Oletum Trogopterori 10g, eupolyphaga 10g, Radix Paeoniae Alba 30g, Rhizoma Corydalis 30g, Radix Glycyrrhizae Preparata 10g day by day.
The primary tumor of metastatic tumor of bone of the present invention includes but not limited to breast carcinoma, pulmonary carcinoma, thyroid carcinoma, renal carcinoma, nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma, lymphoma.
Advantage of the present invention and beneficial effect:
(1) Chinese prescription of the present invention, pharmaceutical preparation the experiment proved that good effect, toxic and side effects are little, low price, are suitable for clinical universal use;
(2) Chinese prescription of the present invention can make the medicine of various ways, as capsule, tablet, pill, granule, meets the demand of different patient.
Detailed description of the invention
In order to understand better and implement, further illustrate the present invention below in conjunction with embodiment.If no special instructions, embodiments of the invention only for explaining the present invention, and do not mean that restriction protection scope of the present invention.
The preparation of embodiment 1 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 10 parts, Poria (Poria cocos (Schw.) Wolf) 10 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 15 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 10 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 15 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 8 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 15 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 15 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 5 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 6h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1h and filters, and second time adds 2 times amount soak by water 0.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 2 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 15 parts, Poria (Poria cocos (Schw.) Wolf) 15 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 20 parts, 30 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 15 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 20 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 12 parts, Pollen Typhae (Typha angustifolia L.) 15 parts, Oletum Trogopterori (Faeces Trogopterori) 15 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 15 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 8h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 2h and filters, and second time adds 2 times amount soak by water 1h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 3 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 18 parts, 18 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 18 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 18 parts, Olibanum (Boswellia carterii Birdw.) 11 parts, Pollen Typhae (Typha angustifolia L.) 12 parts, Oletum Trogopterori (Faeces Trogopterori) 11 parts, eupolyphaga (ground beetle) 9 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 20 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 20 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 10h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 3h and filters, and second time adds 2 times amount soak by water 1.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 4 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 20 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 8h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1h and filters, and second time adds 2 times amount soak by water 0.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 5 pharmaceutical preparation
1, the preparation of oral liquid
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) extract prepared by step (1) is concentrated into original 1/20, cold preservation, gets supernatant and is again concentrated into 2/3, cold preservation, centrifugal, the sucrose that centrifugal liquid adds raw material of Chinese medicine total amount 1/5 weight portion boils dosing, bottling, sealing sterilizing, obtained oral liquid.
2, the preparation of pill
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) ball is made by extractum group prepared by step (2), obtain pill.
3, the preparation of granule
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) add the sucrose of the starch of raw material of Chinese medicine total amount 1/10 weight portion, 1/10 weight portion, make granule; Or add the dextrin of raw material of Chinese medicine total amount 1/5 weight portion, make granule; Or add the aspartame of the starch of raw material of Chinese medicine total amount 1/5 weight portion, 1/2000 weight portion, make granule.
4, the preparation of capsule
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extract dry prepared by step (2), pulverize and sieve, incapsulate shell, capsule.
5, the preparation of tablet
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extractum prepared by step (2), add the starch mixing of raw material of Chinese medicine total amount 1/5 weight portion, make granule, dry, tabletting, makes tablet.
The curative effect of embodiment 6 pharmaceutical preparation
1, study subject: 300 routine patients all derive from specific disease outpatient and inpatient, have trackability, all can coordinate experiment.200 routine patients undergoing surgery, the definitive pathological diagnosis such as bronchoscope and lymph node biopsy is malignant tumor, and the kind of malignant tumor comprises breast carcinoma, pulmonary carcinoma, thyroid carcinoma, renal carcinoma, nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma, lymphoma.Be diagnosed as metastatic tumor of bone through imaging examinations such as ECT, MRI, CT, x-ray, PET-CT, meet the patient of following standard simultaneously, the age is between 18-70 years old; Do not carry out the treatments such as metastatic tumor of bone local radiotherapy, chemotherapy, Diphosphonate and nucleic; Estimate that survival period was more than 6 months.Other 100 routine patients are through being diagnosed as Patients with Osteosarcoma.
2, Therapeutic Method: patient often takes the pharmaceutical preparation (can be oral liquid, granule, tablet or capsule) be equivalent to containing Radix Codonopsis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rehmanniae Preparata 20g, Cortex Eucommiae 12g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 30g, Olibanum 10g, Pollen Typhae 10g, Oletum Trogopterori 10g, eupolyphaga 10g, Radix Paeoniae Alba 30g, Rhizoma Corydalis 30g, Radix Glycyrrhizae Preparata 10g day by day.The every bu of pharmaceutical preparation three picked-ups of above-mentioned dosage, take 3 months continuously.3 months post-evaluation curative effects.
3, efficacy assessment standard
Bone pain palliation rate is with reference to VRS method, and pain divides 4 grades, 0 grade: painless; I level: slight, pain can tolerate, and does not affect sleep, can orthobiosis; II level: moderate, pain is obvious, and can not tolerate, sleep is disturbed, and requires to take analgesic, can with autonomic nervous dysfunction or positive position; M level: severe, sharp ache, can not tolerate, sleep by severe jamming, need take analgesic, can with autonomic nervous dysfunction or positive position.Pain relieving standard: effective, pain relief more than II grade.Effective: pain relief I level.Invalid: pain slightly alleviates, but far less than I level or pain without alleviating or increasing the weight of.Evaluation on quality of life standard is scored by Kamofsky scoring criteria, and the increase >10 person of dividing that scores is raising; Reduce >10 and be divided into reduction; The increase and decrease <10 person of dividing is stable.
4, result
Use pharmaceutical preparation of the present invention treatment osteosarcoma osteodynia or Painful bone metastases effective percentage to reach more than 95%, the lighter one week, severe one is obviously alleviated for one month.
Table 1 bone pain palliation rate curative effect
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. treat the Chinese prescription of osteosarcoma osteodynia and metastatic tumor of bone osteodynia for one kind, it is characterized in that, described Chinese prescription is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis 10-15 part, Poria 10-15 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Rehmanniae Preparata 15-30 part, Cortex Eucommiae 10-15 part, Fructus Ligustri Lucidi 15-20 part, Radix Salviae Miltiorrhizae 15-30 part, Olibanum 10-12 part, Pollen Typhae 10-15 part, Oletum Trogopterori 10-15 part, eupolyphaga 8-10 part, Radix Paeoniae Alba 15-30 part, Rhizoma Corydalis 15-30 part, Radix Glycyrrhizae Preparata 5-15 part.
2. Chinese prescription according to claim 1, it is characterized in that, described Chinese prescription is formulated by the raw material of Chinese medicine of following weight: Radix Codonopsis 12 parts, Poria 12 parts, Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Radix Rehmanniae Preparata, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 15 parts, Radix Salviae Miltiorrhizae 30 parts, Olibanum 10 parts, Pollen Typhae 10 parts, Oletum Trogopterori 10 parts, eupolyphaga 10 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Corydalis 30 parts, Radix Glycyrrhizae Preparata 10 parts.
3. treat a pharmaceutical preparation for osteosarcoma osteodynia and metastatic tumor of bone osteodynia, it is characterized in that, the effective ingredient of described pharmaceutical preparation is prepared from by the Chinese prescription described in claim 1 or 2.
4. pharmaceutical preparation according to claim 3, is characterized in that, the dosage form of described pharmaceutical preparation is the conventional oral dosage formulations on pharmaceutics.
5. pharmaceutical preparation according to claim 4, is characterized in that, described peroral dosage form is oral liquid, granule, pill, tablet, capsule.
6. a preparation method for the Chinese prescription described in claim 1 or 2, is characterized in that, the concrete operation step of described preparation method is as follows:
(1) get it filled by the raw material of Chinese medicine proportioning described in claim 1 or 2, clear water soaks;
(2) medicament mixed through soaking is put into drug-decocting appliance and decoct twice, first time adds 3 times amount soak by water and filters, and second time adds 2 times amount soak by water and filters;
(3) twice decoction liquor is merged, needed for the Chinese medicine extract of acquisition is.
7. preparation method according to claim 6, is characterized in that, the concrete maneuvering sequence of described preparation method is as follows:
(1) get it filled by the raw material of Chinese medicine proportioning described in claim 1 or 2, clear water soaks 6-10h;
(2) medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1-3h and filters, and second time adds 2 times amount soak by water 0.5-1.5h and filters;
(3) bottling of twice decoction liquor is merged, needed for the drug extract of acquisition is.
8. the application of the Chinese prescription described in claim 1 or 2 in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
9. the application of the pharmaceutical preparation according to any one of claim 3-5 in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
10. application according to claim 8 or claim 9, it is characterized in that, described medicine is the pharmaceutical preparation according to any one of claim 3-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510130068.6A CN104666658A (en) | 2015-03-24 | 2015-03-24 | Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510130068.6A CN104666658A (en) | 2015-03-24 | 2015-03-24 | Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104666658A true CN104666658A (en) | 2015-06-03 |
Family
ID=53302594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510130068.6A Pending CN104666658A (en) | 2015-03-24 | 2015-03-24 | Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104666658A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267886A (en) * | 2015-11-28 | 2016-01-27 | 隋丽红 | Traditional Chinese medicine composition for treating osteosarcoma and plaster preparation method thereof |
| CN105853742A (en) * | 2016-05-30 | 2016-08-17 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for thyroid cancer with osseous metastasis |
| CN106309585A (en) * | 2015-07-01 | 2017-01-11 | 上海中医药大学附属龙华医院 | Traditional Chinese medicinal composition with effect of relieving ostealgia of tumor patient, and application of traditional Chinese medicinal composition in pain-easing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908563A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine medicament for treating extraskeletal osteosarcoma and preparation method thereof |
-
2015
- 2015-03-24 CN CN201510130068.6A patent/CN104666658A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908563A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine medicament for treating extraskeletal osteosarcoma and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 盛展能: "《抗癌治验本草》", 31 July 1994 * |
| 陈德货: "定痛汤加味治疗癌性疼痛45例", 《湖北中医杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309585A (en) * | 2015-07-01 | 2017-01-11 | 上海中医药大学附属龙华医院 | Traditional Chinese medicinal composition with effect of relieving ostealgia of tumor patient, and application of traditional Chinese medicinal composition in pain-easing |
| CN106309585B (en) * | 2015-07-01 | 2019-09-27 | 上海中医药大学附属龙华医院 | A traditional Chinese medicine composition for improving bone pain in tumor patients and its application in analgesia |
| CN105267886A (en) * | 2015-11-28 | 2016-01-27 | 隋丽红 | Traditional Chinese medicine composition for treating osteosarcoma and plaster preparation method thereof |
| CN105853742A (en) * | 2016-05-30 | 2016-08-17 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for thyroid cancer with osseous metastasis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103536758B (en) | Traditional Chinese medicinal composition for treating night sweat due to yin deficiency | |
| CN103550696B (en) | Medicine for treating lung cancer | |
| CN105663607A (en) | Traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN103977217A (en) | Medicinal composition for treating renal carcinoma | |
| CN106511864A (en) | Traditional Chinese medicine composition and preparation method and applications thereof in treatment of cervical carcinoma | |
| CN105056133A (en) | Traditional Chinese medicine pills for treating fibromyalgia syndrome and preparing method of traditional Chinese medicine pills | |
| CN101455795B (en) | Traditional Chinese medicine preparation for treating spontaneous perspiration and preparation method thereof | |
| CN104689096A (en) | Depressive neurosis treating traditional Chinese medicine composition | |
| CN103394030B (en) | Traditional Chinese medicine composition for treating depressed liver and deficient spleen | |
| CN106421432A (en) | Traditional Chinese medicine for treating aged body deficiency syndrome and delaying senescence | |
| CN101284093B (en) | Chinese herb medicine for treating coronary heart disease | |
| CN104606561A (en) | Traditional Chinese medicinal composition for treating spontaneous perspiration | |
| CN104258369A (en) | Traditional Chinese medicine composition for treating epigastric pain | |
| CN104042981A (en) | Medicament for treating postnatal constipation and preparation method thereof | |
| CN102949698A (en) | Medicine for treating uterine myoma and preparation method thereof | |
| CN102836276B (en) | Bone spur softening pill for treating osteoarthritis | |
| CN103845690A (en) | Medicament for treating geriatric depression | |
| CN102247584B (en) | Traditional Chinese medicine for treating kidney-deficiency vertigo and preparation method thereof | |
| CN104547553A (en) | Traditional Chinese medicine for treating nervous endocrine disorder | |
| CN104547369A (en) | Oral medicine for treating blepharospasm and preparation method thereof | |
| CN104826079A (en) | Traditional Chinese medicine for treating parturient paresis | |
| CN104857370A (en) | Traditional Chinese medicine composition for treating breast cancer | |
| CN104398789A (en) | Traditional Chinese medicine decoction for treating iron-deficiency anemia | |
| CN103239574A (en) | Traditional Chinese medicine for treating postpartum aphagia of pig | |
| CN102688453A (en) | Traditional Chinese medicine composite for treating breast cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150603 |
|
| RJ01 | Rejection of invention patent application after publication |