CN101810743A - Normal temperature preparation method for submicron powder of sexual maturity promoting powder - Google Patents
Normal temperature preparation method for submicron powder of sexual maturity promoting powder Download PDFInfo
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- CN101810743A CN101810743A CN200910227509A CN200910227509A CN101810743A CN 101810743 A CN101810743 A CN 101810743A CN 200910227509 A CN200910227509 A CN 200910227509A CN 200910227509 A CN200910227509 A CN 200910227509A CN 101810743 A CN101810743 A CN 101810743A
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Abstract
The invention discloses a normal temperature preparation method for submicron powder of a sexual maturity promoting powder. The method comprises the following steps of: medicine selection: selecting 6 parts of epimedium, 6 parts of actinolite, 4 parts of angelica, 5 parts of nut grass, 6 parts of motherwort and 5 parts of dodder in parts by weight; washing, airing, and cutting into long sections of 3-5cm for later use; crude powder, crushing the cut traditional Chinese medicines, and sieving by using a sieve of 65 meshes; mixing: uniformly mixing the powders; fine powder: crushing the mixing powder into the finest powder, and sieving by using a sieve of 100 meshes; and submicron powder: carrying out micronization on the fine powder into submicron powder, wherein the powder size is 20-40 micrometers. The preparation is carried out at normal temperature, and has no need of low-temperature or special condition; the wall breaking rate and biological utilization degree of cells are enhanced, and the pharmacological action is strengthened; the amount of the consumed medicines is reduced, thereby saving medicines; the submicron powder can be directly taken along with water drinking; and the preparation process is simple, the quality is standard and controllable, therefore, the invention is suitable for scale production requirement.
Description
Technical field
The present invention relates to a kind of preparation method of veterinary drug, especially relate to the normal temperature preparation method of submicron powder of sexual maturity promoting powder.
Background technology
China is vast in territory, extends across cold, warm, hot three bands, and one of country that the resources of medicinal plant that is richly stored with is wild in the world medicinal plants most species, utilize the earliest, utilization rate is the highest is accumulating rich experience aspect the utilization Chinese herbal medicine.Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect; Be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under the overall background of green ecological, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
Tradition is promoted the sexual maturity to loose with veterinary drug and is made up of Herba Epimedii, Actinolitum, Radix Angelicae Sinensis, Rhizoma Cyperi, Herba Leonuri and Semen Cuscutae 6 flavor Chinese medicines, and wherein Herba Epimedii, Actinolitum, Radix Angelicae Sinensis, Herba Leonuri and Semen Cuscutae are all on the books in Shennong's Herbal.Herba Epimedii acrid in the mouth, sweet, warm in nature is returned liver, kidney channel, and the effect of warming the kidney to invigorate YANG, bone and muscle strengthening, wind-damp dispelling is arranged; Be used for cards such as myalgia due to the deficiency of the liver and kindey, rheumatism contracture numbness.Actinolitum is the silicates mineral, and salty in the mouth, warm in nature is gone into kidney channel, the effect of warming the kidney to invigorate YANG is arranged, promoting the sexual maturity, be used for infertile and waist unable etc.The Radix Angelicae Sinensis sweet in the mouth is flat, and is warm in nature, is widely used in clinically so far, have the title of " ten side's rules for doing division with a one-digit divisor on the abacus ", the good reputation of " king of medicine ".Motherland's medical science thinks, Radix Angelicae Sinensis have enrich blood invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation, the strong bone of granulation promoting.Herba Leonuri acrid in the mouth, little hardship, cold nature is gone into pericardium, Liver Channel, has eliminating blood stasis to promote regeneration of blood, the effect of promoting blood flow to regulate menstruation, traditional medicine is applied to treat obstetrical and gynecological disease with Herba Leonuri and preparation thereof, and Herba Leonuri is called as the credit panacea.Semen Cuscutae acrid in the mouth, property are put down, and go into the liver,kidney,spleen warp; But nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.This preparation is widely used on veterinary clinic because of waist suffer from a deficiency of the kidney cattle, horse, pig, sheep non-estrus that cold, infertility, stagnation of QI-blood, salpingitis etc. cause or join infertile etc. for a long time.
Used promoting the sexual maturity at present is dispersed in domestic animal promoting the sexual maturity of animals and promoting gravidity aspect better effects, but also has following shortcoming, and 1. medicated powder is thick, and its particle diameter is the 250-850 micron; 2. using dosage is big: horse, cattle 150-250g, sheep, pig 30-45g; 3. presentation quality and palatability are poor, and Chinese medicine powder exists very intensive bitterness and abnormal flavour, makes animal dislike eating; 4. effective ingredient can not fully discharge, and bioavailability is low, has had a strong impact on Chinese medicine quality and therapeutic effect, has restricted application clinically.
Summary of the invention
The object of the present invention is to provide a kind of veterinary drug rapid-action, that curative effect is high, bioavailability is high diffusing normal temperature preparation method of promoting the sexual maturity.
The normal temperature preparation method of submicron powder of sexual maturity promoting powder of the present invention, it comprises the steps:
The first step, select medicine: choose 6 parts of Chinese crude drug Herba Epimedii, 6 parts of Actinolitum, 4 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Cyperis, 6 parts of Herba Leonuris, Semen Cuscutae according to weight portion and clean, dry for 5 parts, it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m, the powder amount of crossing 80 mesh sieves is no more than 60%;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the 3rd step gained mixed powder is ground into fine powder with universal mill, crosses 100 mesh sieves, powder diameter 100-150 μ m, the powder amount of crossing 120 mesh sieves is no less than 95%;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder diameter 20-40 μ m can obtain the submicron powder of sexual maturity promoting powder finished product.
The submicron powder of sexual maturity promoting powder finished product is sub-packed in the aluminium foil bag every bag heavy 100g, 200g, 500g, 1000g, 2000g etc.
The invention has the advantages that:
1. whole process of preparation is all carried out at normal temperatures, does not need the preparation of low temperature or specific condition.
2. with after the crude drug micronizing, improve cell wall breaking rate and bioavailability, can strengthen pharmacological action.
3. minimizing dosage is saved medical material, and resource conservation improves abnormal smells from the patient, mouthfeel, improves drug quality, has prolonged storage life.
4. adopt the submicron powder of sexual maturity promoting powder of the present invention's preparation, can be directly used in drinking-water and using, drug effect is brought into play to greatest extent, changed the instructions of taking that Chinese powder medicine can only spice can not be drunk water.
5. adopt the submicron powder of sexual maturity promoting powder of the present invention's preparation, its preparation technology is simple, quality standard is controlled, is fit to the large-scale production demand.
Clinical therapeutic efficacy of the present invention:
The infertility of sow is one of principal disease that has a strong impact on the pig industry economic benefit, confirms that by following test the submicron powder of sexual maturity promoting powder preparation of the present invention's preparation is evident in efficacy to treatment sow infertility, and result of the test is as follows:
Trial drug: the made submicron powder of sexual maturity promoting powder preparation of the present invention.
Experimental animal: the three way cross offspring sow of Landrace, big yorker and duroc.Be divided into 3 groups according to the non-estrus persistent period.The I group is for stopping the 15-30 days non-estrus sows in breast back; The II group is for stopping the 31-45 days non-estrus sows in breast back; III group is for stopping newborn back non-estrus sow still more than 45 days.
Test method: carry out the spice treatment of feeding by 15g/ head/sky, 5 days is a course of treatment, is drug withdrawal after occurring oestrusing; Non-estrus still after the course of treatment is also discontinued medication.
Use submicron powder of sexual maturity promoting powder the sow that stops breast back different time non-estrus is treated, the results are shown in Table 1.
Table 1 the effect of promoting the sexual maturity of loosing of promoting the sexual maturity to sow
| Group | Test sow number (head) | Oestrus and count (head) | The rate of oestrusing (%) | Average estrus time after the medication (my god) |
| ??I | ??85 | ??76 | ??89.4 | ??3.3 |
| ??II | ??56 | ??44 | ??78.6 | ??4.4 |
| ??III | ??30 | ??21 | ??70.0 | ??5.1 |
| Add up to | ??171 | ??141 | ??82.5 | ??4.3 |
The infertility sow is used loose conception rate and litter size after the treatment and the situation of the sow that normally oestruses of promoting the sexual maturity and has carried out relative analysis, the results are shown in Table 2.
Sow conception rate after the treatment of table 2 submicron powder of sexual maturity promoting powder and average litter size
| Group | The breeding number | The number of being impregnated | Conception rate (%) | The farrowing sum | Average litter size (head) |
| ??I | ??75 | ??70 | ??93.3 | ??631 | ??9.01 |
| ??II | ??46 | ??41 | ??89.1 | ??355 | ??8.66 |
| ??III | ??24 | ??21 | ??87.5 | ??164 | ??7.81 |
| Add up to | ??145 | ??132 | ??91.0 | ??1150 | ??8.64 |
| Normal group | ??234 | ??224 | ??95.7 | ??2155 | ??9.68 |
Result of the test shows with sow non-return rate after the submicron powder of sexual maturity promoting powder treatment and normal sow does not relatively have significant difference, and the potentia concipiendi that equal capability is arranged with infertility sow after the diffusing treatment of promoting the sexual maturity and normal sow is described.It is the infertility of promoting the sexual maturity and loosing and effectively to treat sow that the present invention prepares.
The specific embodiment
The preparation method of submicron powder of sexual maturity promoting powder of the present invention, whole process of preparation are all carried out at normal temperatures, and its step is as follows:
The first step, select medicine: choose Chinese crude drug Herba Epimedii 6kg, Actinolitum 6kg, Radix Angelicae Sinensis 4kg, Rhizoma Cyperi 5kg, Herba Leonuri 6kg, Semen Cuscutae 5kg clean, dry, it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m, the powder amount of crossing 80 mesh sieves is no more than 60%;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the 3rd step gained mixed powder is ground into fine powder with universal mill, crosses 100 mesh sieves, powder diameter 100-150 μ m, the powder amount of crossing 120 mesh sieves is no less than 95%;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder diameter 20-40 μ m can obtain the submicron powder of sexual maturity promoting powder finished product.
The submicron powder of sexual maturity promoting powder finished product is sub-packed in the aluminium foil bag every bag heavy 1000g.
Claims (1)
1. the normal temperature preparation method of a submicron powder of sexual maturity promoting powder comprises the steps:
The first step, select medicine: choose 6 parts of Chinese crude drug Herba Epimedii, 6 parts of Actinolitum, 4 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Cyperis, 6 parts of Herba Leonuris, Semen Cuscutae according to weight portion and clean, dry for 5 parts, it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the 3rd step gained mixed powder is ground into fine powder with universal mill, crosses 100 mesh sieves, powder diameter 100-150 μ m;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder diameter 20-40 μ m can obtain the submicron powder of sexual maturity promoting powder finished product.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406548A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Method for preparing ultramicro medicinal powder of motherwort at normal temperature and special two-way air stream screening machine therefor |
| CN102512654A (en) * | 2011-12-20 | 2012-06-27 | 长沙施比龙动物药业有限公司 | Swine aphrodisiac powder preparation and its preparation technology |
| CN105393984A (en) * | 2015-12-07 | 2016-03-16 | 黄森林 | Forest mush deer culture method promoting estrus and twinning |
| CN105535343A (en) * | 2015-12-31 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine compound for preventingand treating livestock anestrus and promoting pregnancy |
| CN107519262A (en) * | 2017-10-14 | 2017-12-29 | 杜运升 | One kind is promoted the sexual maturity scattered medicine and preparation method and application |
| CN109394967A (en) * | 2018-11-30 | 2019-03-01 | 合肥中龙神力动物药业有限公司 | A kind of dam submicron powder of sexual maturity promoting powder agent and preparation method thereof |
| CN110432383A (en) * | 2019-08-09 | 2019-11-12 | 内蒙古自治区农牧业科学院 | It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe |
| CN115886155A (en) * | 2022-11-28 | 2023-04-04 | 西北农林科技大学 | Estrus promoting feed additive special for dairy goats and preparation method thereof |
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2009
- 2009-12-17 CN CN200910227509A patent/CN101810743A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406548A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Method for preparing ultramicro medicinal powder of motherwort at normal temperature and special two-way air stream screening machine therefor |
| CN102406548B (en) * | 2011-11-28 | 2013-07-24 | 河南省康星药业股份有限公司 | Method for preparing ultramicro medicinal powder of motherwort at normal temperature |
| CN102512654A (en) * | 2011-12-20 | 2012-06-27 | 长沙施比龙动物药业有限公司 | Swine aphrodisiac powder preparation and its preparation technology |
| CN102512654B (en) * | 2011-12-20 | 2014-02-12 | 长沙施比龙动物药业有限公司 | Swine aphrodisiac powder preparation and its preparation technology |
| CN105393984A (en) * | 2015-12-07 | 2016-03-16 | 黄森林 | Forest mush deer culture method promoting estrus and twinning |
| CN105393984B (en) * | 2015-12-07 | 2018-03-06 | 徐挺 | Woods musk deer, which is promoted the sexual maturity, promotees twin cultural method |
| CN105535343A (en) * | 2015-12-31 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine compound for preventingand treating livestock anestrus and promoting pregnancy |
| CN107519262A (en) * | 2017-10-14 | 2017-12-29 | 杜运升 | One kind is promoted the sexual maturity scattered medicine and preparation method and application |
| CN109394967A (en) * | 2018-11-30 | 2019-03-01 | 合肥中龙神力动物药业有限公司 | A kind of dam submicron powder of sexual maturity promoting powder agent and preparation method thereof |
| CN109394967B (en) * | 2018-11-30 | 2021-06-25 | 合肥中龙神力动物药业有限公司 | Female animal estrus-promoting powder superfine powder and preparation method thereof |
| CN110432383A (en) * | 2019-08-09 | 2019-11-12 | 内蒙古自治区农牧业科学院 | It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe |
| CN115886155A (en) * | 2022-11-28 | 2023-04-04 | 西北农林科技大学 | Estrus promoting feed additive special for dairy goats and preparation method thereof |
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Application publication date: 20100825 |