CN107303384B

CN107303384B - A Chinese medicinal composition for treating various symptoms, and its derivatives and products

Info

Publication number: CN107303384B
Application number: CN201710265665.9A
Authority: CN
Inventors: 张东
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-21
Filing date: 2017-04-21
Publication date: 2021-08-03
Anticipated expiration: 2037-04-21
Also published as: CN107303384A; WO2017181988A1

Abstract

The invention provides a traditional Chinese medicine composition with curative effect on various symptoms, derivatives and products thereof, belonging to the field of traditional Chinese medicine, which is characterized by comprising 1-3 parts by weight of a raw material medicine A, 0.6-1.5 parts by weight of a raw material medicine B, 0.6-1.5 parts by weight of a raw material medicine C and 0-1.5 parts by weight of a raw material medicine D; the raw material medicine A is prepared from honey-fried licorice root, raw licorice root, Chinese date and/or coix seed; the raw material medicine B is red ginseng; the raw material medicine C is fried bighead atractylodes rhizome; the bulk drug D is 1 part by weight of dried ginger, baked ginger or tuckahoe, and the multi-indication traditional Chinese medicine composition can be matched with various bulk drugs to derive traditional Chinese medicine compositions suitable for different symptoms.

Description

A Chinese medicinal composition for treating various symptoms, and its derivatives and products

Technical Field

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition with curative effect on various symptoms and a derivative traditional Chinese medicine composition and a product thereof.

Technical Field

The middle energizer decoction is first recorded in Shang Han Lun (treatise on Cold-induced diseases) by Zhang Zhongjing and mainly treats deficiency-cold of Taiyin, and has the effects of warming middle energizer to dispel cold, and tonifying qi and spleen. Is one of the commonly used clinical prescriptions. The "Shangshi Lun" records the recipe of Lizhong Wan: ginseng, dried ginger, licorice root (roasted), white atractylodes rhizome, three for two, respectively. The four ingredients are added, smashed and sieved, and mixed with honey into pills, such as chicken yolk, which is large in volume. The decoction is mixed with one pill, ground and taken warmly, three days and four days and two nights. No heat in the abdomen, it is good for the three and four pills, which do not reach the decoction. The decoction method comprises cutting the four materials into two parts, decocting with water eight liters, decocting three liters, removing residues, and warm taking one liter, three days taking. The "jin Kui Yao L ü e" is called ginseng decoction. The two ancient books describe the middle-jiao regulating soup/pill as follows:

cholera, headache, fever, body pain, heat with desire for water, five-poria with powder as the main component; for cold without water, the middle-jiao-Wan is the main herb. "(" Shanghai treatise on Cold-fever syndrome and syndrome differentiation of cholera)

"after a large disease difference, it is with a preference for saliva, not seen for a long time, and cold in chest, so it is advisable to use pills for warming the middle energizer. "(" Shanghai treatise on Cold-induced diseases "& syndrome of recovery from fatigue and pulse after differentiation of Yin and Yang and easiness)

For chest stuffiness and fullness in heart, retained qi is in chest, fullness in chest, adverse flow of qi in hypochondrium and robbing heart, Zhi Shi Xie Bai Gui Tang is also used in ren Shen Tang. "(" jin Kui Yao L ü e chest bi-arthralgia with short breath syndrome treatment ninth)

The study of the study by scholars in all aspects has been continued since ancient times, and 2014 studies the difference in the drug effects of different doses of the formulas in the middle-jiao soup ancient times and modern times on the influence of different doses of the viscera coefficients of the spleen yang deficiency mice; the scholars also study the preparation process of the formulation, and the Chinese patent application 200910263155.3 entitled "preparation technology of an integrated new formulation of Zhongtang" discloses a new formulation of Zhongtang, which is helpful for improving the targeting property and slow release property of the drug and can be made into skin patches for human body, etc.

However, few reports have been made on the development of indications of Zhongtang.

Disclosure of Invention

The invention provides a pharmaceutical composition and a product thereof, wherein the pharmaceutical composition is a classic formula middle-jiao decoction, but the formula meaning and the application range are completely different from those of the middle-jiao decoction. The technical scheme provided by the invention is as follows:

a Chinese medicinal composition with therapeutic effect on various symptoms is characterized by comprising 1-3 parts by weight of a raw material medicament A, 0.6-1.5 parts by weight of a raw material medicament B, 0.6-1.5 parts by weight of a raw material medicament C and 0-1.5 parts by weight of a raw material medicament D;

the raw material medicine A is prepared from radix glycyrrhizae preparata, Chinese date and/or coix seed;

the raw material medicine B is red ginseng;

the raw material medicine C is fried bighead atractylodes rhizome;

the raw material medicine D is dried ginger, baked ginger or tuckahoe;

the symptoms include coronary heart disease, hyperlipidemia, arrhythmia, heart failure, hypertension, type II diabetes, cardiac neurosis, dermatosis, menopathy, painful disease, constipation, insomnia, cervical spondylosis, lumbar spondylosis, common cold, chronic bronchitis, human papilloma virus infection, hyperthyroidism, nervous tremor, spermatorrhea, impotence, infantile hyperactivity disorder, depression, climacteric syndrome, chronic colitis, chronic gastritis, reflux esophagitis, tumor rehabilitation, peripheral neuropathy, chronic urinary infection, allergic diseases, herpes zoster, cerebrovascular disease and hematopathy.

Preferably, the traditional Chinese medicine composition is composed of 1-3 parts by weight of the raw material medicine A, 0.6-1.5 parts by weight of the raw material medicine B, 0.6-1.5 parts by weight of the raw material medicine C and 0.6-1.5 parts by weight of the raw material medicine D.

Preferably, the multi-indication traditional Chinese medicine composition is characterized by consisting of 1-3 parts by weight of raw material medicine A, 1 part by weight of raw material medicine B, 1 part by weight of raw material medicine C and 1 part by weight of raw material medicine D.

A Chinese medicinal composition is prepared by adding any one of the following auxiliary materials into the Chinese medicinal composition with therapeutic effect on various symptoms

Schizonepeta and ledebouriella root; red yeast rice; rhizoma Sparganii and Curcumae rhizoma; rhizoma Alismatis and herba Lycopi; turmeric root tuber; morinda officinalis; fructus Lycii and herba Epimedii; morinda officinalis and epimedium; kudzu root; agastache rugosa and eupatorium; radix Adenophorae and radix Ophiopogonis; astragalus root; largehead atractylodes rhizome; poria with hostwood; pinellia ternata; cistanche deserticola; eucommia ulmoides and achyranthes bidentata; clove and calyx kaki; poria and Alismatis rhizoma; flos Magnoliae and fructus Xanthii; flos Inulae and Haematitum; rhizoma Gastrodiae; garden burnet and sophora fruit; rhizoma corydalis; safflower and motherwort; rhizoma Smilacis Glabrae; aster and coltsfoot; ephedra and almond; pinellia ternata and platycodon grandiflorum; rhizoma Belamcandae and herba Ephedrae; radix Angelicae sinensis; red sage root and safflower; radix Ophiopogonis and fructus Schisandrae; red ginseng; turmeric root-tuber and albizzia flower; albizzia flower; radix astragali, fructus Ligustri Lucidi and fructus Psoraleae; honey ephedra or raw ephedra; colla Corii Asini; radix Angelicae sinensis; white peony root; rhizoma Wenyujin Concisa; herba asari; cinnamon; herba Lycopodii; morinda officinalis; dogwood fruit; prepared rehmannia root; radix rehmanniae; squama Manis; tortoise plastron; carapax Trionycis; radix codonopsitis; ginseng; notoginseng radix; costus root; clematis root; leeches; scorpio; centipede; cortex Albizziae; wild jujube seed; immature bitter orange; gynostemma pentaphylla; buxine; radix asteris; colla cornus cervi; tortoise-plastron glue; peach kernel; earthworm; semen Hoveniae; semen Cuscutae; locking the yang; and (4) splitting the core wood.

Preferably, the auxiliary raw material medicines comprise the following components in parts by weight:

0.6 to 1.5 weight parts of schizonepeta and 0.6 to 1.5 weight parts of divaricate saposhnikovia root;

0.6 to 1.5 portions of red yeast;

0.6 to 1.5 weight portions of rhizoma sparganii and 0.6 to 1.5 weight portions of rhizoma zedoariae;

0.6 to 1.5 weight portions of alisma orientale and 0.6 to 1.5 weight portions of eupatorium japonicum;

0.6 to 1.5 weight parts of curcuma aromatica;

0.6 to 1.5 weight parts of morinda officinalis;

0.6 to 1.5 weight parts of medlar and 0.6 to 1.5 weight parts of epimedium;

0.6 to 1.5 weight parts of morinda officinalis and 0.6 to 1.5 weight parts of epimedium;

0.8 to 1.2 portions of kudzu root;

0.6 to 1.5 weight portions of ageratum and 0.6 to 1.5 weight portions of eupatorium;

0.6 to 1.5 parts of adenophora stricta and 0.6 to 1.5 parts of ophiopogon root;

0.6 to 1.5 weight portions of astragalus;

0.6 to 1.5 weight parts of largehead atractylodes rhizome;

0.6 to 1.5 weight portions of poria with hostwood;

0.6 to 1.5 weight parts of pinellia ternate;

0.6 to 1.5 parts by weight of cistanche;

0.6 to 1.5 weight parts of eucommia bark and 0.6 to 1.5 weight parts of achyranthes root;

0.6 to 1.0 weight part of clove and 0.6 to 1.0 weight part of calyx kaki;

0.6 to 1.5 weight parts of tuckahoe and 0.6 to 1.5 weight parts of alisma orientale;

0.6 to 1.0 weight portion of biond magnolia flower and 0.6 to 1.0 weight portion of siberian cocklebur fruit;

0.6 to 1.5 weight parts of inula flower and 0.6 to 3 weight parts of ruddle;

0.6 to 2 weight parts of gastrodia elata;

0.6 to 1.5 weight parts of garden burnet and 0.6 to 1.5 weight parts of sophora fruit;

0.6 to 1.5 weight portions of rhizoma corydalis;

0.6 to 1.5 weight parts of safflower and 0.6 to 1.5 weight parts of motherwort;

0.6 to 1.5 weight portions of glabrous greenbrier rhizome;

0.6 to 1.5 weight parts of aster and 0.6 to 1.5 weight parts of coltsfoot;

0.6 to 1.0 weight portion of ephedra and 0.6 to 1.5 weight portions of almond;

0.6 to 1.5 weight parts of pinellia ternate and 0.6 to 1.5 weight parts of platycodon grandiflorum;

0.6 to 1.5 weight parts of blackberrykiky rhizome and 0.6 to 1.0 weight part of ephedra;

0.6 to 1.5 weight portions of angelica;

0.6 to 1.5 weight portions of salvia miltiorrhiza and 0.6 to 1.5 weight portions of safflower;

0.6 to 1.5 weight parts of dwarf lilyturf tuber and 0.6 to 1.5 weight parts of Chinese magnoliavine fruit;

0.6 to 1.5 weight parts of red ginseng;

0.6 to 1.5 weight portions of curcuma aromatica and 0.6 to 1.5 weight portions of albizia flower.

0.6 to 1.5 weight portions of albizzia flower

0.6-1.5 parts of astragalus root, 0.6-1.5 parts of glossy privet fruit and 0.6-1.5 parts of fructus psoraleae;

0.6 to 1.5 weight parts of honey ephedra or raw ephedra;

0.6 to 1.5 weight parts of donkey-hide gelatin;

0.6 to 1.5 weight portions of angelica; 0.6 to 1.5 weight portions of white paeony root;

0.6 to 1.5 weight parts of rhizoma wenyujin concinnatae;

0.3-0.6 weight part of asarum;

0.6 to 1.5 weight parts of cinnamon;

0.6 to 1.5 parts of common clubmoss herb;

0.6 to 1.5 weight parts of morinda officinalis;

0.6 to 1.5 weight parts of dogwood;

0.6 to 1.5 parts by weight of prepared rehmannia root;

0.6 to 1.5 weight parts of dried rehmannia root;

pangolin scales 0.6-1.5 weight portions;

0.6 to 1.5 portions of tortoise plastron;

0.6 to 1.5 portions of turtle shell;

0.6 to 1.5 weight parts of codonopsis pilosula;

0.6 to 1.5 weight portions of ginseng;

0.6 to 1.5 weight parts of pseudo-ginseng;

0.6 to 1.5 portions of costustoot;

0.6 to 1.5 parts of clematis root;

0.6 to 1.5 weight parts of leech;

0.6 to 1.5 weight portions of scorpion;

centipede 0.6-1.5 weight portions;

0.6 to 1.5 weight parts of silktree albizzia bark;

0.6 to 1.5 weight parts of spina date seed;

0.6 to 1.5 weight parts of immature bitter orange;

0.6 to 1.5 weight parts of gynostemma pentaphylla;

0.6 to 1.5 weight parts of buxine;

0.6 to 1.5 weight portions of aster;

0.6 to 1.5 parts by weight of antler glue;

0.6-1.5 parts of tortoise-plastron glue;

0.6 to 1.5 parts of peach kernel;

0.6 to 1.5 portions of earthworm;

0.6 to 1.5 parts by weight of hovenia dulcis thunb;

0.6 to 1.5 weight parts of dodder;

0.6 to 1.5 weight portions of cynomorium songaricum;

0.6 to 1.5 parts of diaphragma juglandis.

On the other hand, the invention provides a series of traditional Chinese medicine products based on the traditional Chinese medicine composition with curative effect on various symptoms and the traditional Chinese medicine composition derived from the traditional Chinese medicine composition as raw materials.

Preferably, the dosage form of the traditional Chinese medicine product is oral decoction, powder, granules, pills, tablets, capsules, extracting solution and external dosage forms.

Preferably, the Chinese medicinal preparation further comprises acceptable auxiliary materials for preparing the required dosage form.

The invention also provides a preparation method of the traditional Chinese medicine product, which is characterized in that the preparation method comprises the step of decocting the raw materials to obtain a traditional Chinese medicine water extracting solution.

Preferably. The preparation method comprises decocting Ginseng radix Rubri for at least 15 min, and adding the rest materials for decocting.

The middle energizer regulating pill, recorded in Shang Han Lun of Zhang Zhongjing, regulates the middle energizer, is mainly used for treating deficiency-cold of Taiyin, warming middle energizer to dispel cold, and invigorating qi and spleen. The ginseng used in the method does not exist at present. The subsequent generations generally use northeast ginseng or radix codonopsitis as a substitute, but radix codonopsitis and northeast ginseng are not one family, radix codonopsitis is the platycodonaceae, while northeast ginseng is commonly called ginseng as Araliaceae, radix codonopsitis strengthens spleen and stomach, tonifies middle-warmer energy, but has weaker tonifying power than ginseng. The Shen has recorded in Shen nong Ben Cao Jing (Shen nong's herbal medicine) that the Shen tonifies five internal organs, calms spirit and soul, and the Dang Shen has no such effect. In the ginseng of Araliaceae, the use of ginseng in the future is different, and some of them are described as sun-dried ginseng or red ginseng. The northeast ginseng (ginseng) is dug out from the ground, cleaned and dried in the sun and is called sun-dried ginseng or white ginseng; the red ginseng is prepared by soaking northeast ginseng (Ginseng radix) in boiling water, soaking in sugar juice, taking out, and drying in the sun. Therefore, compared with red ginseng, sun-dried ginseng is a raw product and a cooked product, and as mentioned above, the processed and cooked Chinese herbs are slightly tonic, the raw product is slightly diarrhea, the raw product is mostly scattered, and the cooked product is mostly solid and astringent, so they are different.

The invention provides a traditional Chinese medicine composition (guanfu soup) for removing fetus and regulating middle warmer, which consists of honey-fried licorice root or red date, red ginseng, fried white atractylodes rhizome, tuckahoe and dried ginger, and the dosage proportion is as follows: 1-1.5: 1: 1: 1. the product of the invention changes the ginseng or the codonopsis pilosula in the Zhongzhong decoction into the red ginseng, and is not used as a monarch drug any more. The largehead atractylodes rhizome is replaced by the stir-fried largehead atractylodes rhizome, so that the guanfu soup is relatively more astringent and warm-tonifying. In terms of traditional Chinese medicine preparation, the preparation is generally that the cooked product is partially tonic and the raw product is partially laxative; the unprocessed one is mostly scattered and the cooked one is mostly solid and astringent. For instance, Sheng Di Huang and Shu Di Huang are indicated in Ben Cao gang mu that Sheng is cold in nature and cooling blood and blood heat in need, while it is warm in maturity and tonifying kidney and blood deficiency in need. And raw licorice and prepared licorice, raw white atractylodes rhizome and fried white atractylodes rhizome, raw white peony root and fried white peony root, raw fleece-flower root and cooked fleece-flower root, etc. Therefore, compared with rhizoma Atractylodis Macrocephalae, the stir-fried rhizoma Atractylodis has the actions of strengthening yang and yang.

The recipe is designed to have red ginseng, which enters the heart and has stronger astringency after being steamed, so the recipe is used in the decoction. The "medical inspiration" means that ginseng "tonifies original qi, which is either absent from middle energizer or supplemented by herbs, and enters middle energizer to promote the transformation and transformation of spleen and stomach, and the original qi is generated by itself, and another herb is Bai Zhu. [ solution ] AHerbal medicine for dredging channels and collateralsA large section of: bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, is the most important herb for tonifying spleen and stomach. The book Ben Cao Quzhen is called as the first herb for spleen tonifying qi, and Bighead Atractylodes rhizome has the meaning of bitter descending. Gan Jiang is warming the middle energizer, while gan Jiang is in the middle energizer and is in the astringing sense. After all, the spleen is cold-damp, the dried ginger and the white atractylodes rhizome are bitter and warm and dry, while the dried ginger is pungent and disperses and warms the middle and dispels dampness. And dried ginger makes the sight restoring soup still, neutral and dynamic. Prepared licorice root, radix Glycyrrhizae Praeparata, is the monarch drug that brings the cluster drugs into the center of the circle, as with the Chinese medicine-Yiyin, so the dosage is the largest. Red ginseng astringes heart qi going up, bitter and lowers deficiency fire, it is from summer to astringe yang qi to make yin grow, prepared licorice root collects yang qi in spleen and stomach middle energizer, white atractylodes rhizome and dried ginger take away the repentant yang to make yin and yang harmonize, and primordial qi self-recovers, so it is named as Dufu Tang.

In terms of indications, the compound decoction has wider indications than the middle-jiao decoction, is only not suitable for patients with insufficient kidney reserve and patients with yin deficiency and yang hyperactivity, and is also not suitable for general heat toxin exuberance, particularly symptoms of heat entering nutrient and blood. According to clinical observation, the traditional Chinese medicine composition disclosed by the invention shows remarkable curative effects on various symptoms such as coronary heart disease, hyperlipidemia, arrhythmia, heart failure, hypertension, type 2 diabetes, cardiac neurosis, eczema, acne, irregular menstruation, arthralgia, headache, constipation, insomnia, cervical spondylosis, cold, chronic bronchitis, human papilloma virus infection, hyperthyroidism, nervous tremor, spermatorrhea, impotence, infantile hyperactivity, depression, femoral head necrosis pain, climacteric syndrome, chronic colitis, chronic gastritis, reflux esophagitis, tumor rehabilitation, peripheral neuropathy, chronic urinary infection, allergic diseases, herpes zoster and other symptoms of discomfort in the middle-jiao decoction.

In the traditional Chinese medicine composition, the honey-fried licorice root and the Chinese date can be used interchangeably or mixed, and particularly, for patients with the contraindication of the honey-fried licorice root, the Chinese date can be completely adopted, so that the traditional Chinese medicine composition (the guan-fu soup) has wider and safer application range. Clinical practice cases prove that the multi-indication traditional Chinese medicine composition can be combined with various auxiliary raw material medicines to obtain a formula which is more pertinent and better for specific indications, so that the traditional Chinese medicine composition has wide and pertinent indication range, and according to clinical experimental examples, the effect observation and verification data of each formula at least come from 10 cases, some hundreds of cases are as follows:

herba Schizonepetae and radix Saposhnikoviae are added, so that the curative effect on erythra is better, and the treatment course is 2-3 weeks;

the addition of red yeast rice has better effect on hyperlipemia, and the treatment course is 2-3 months;

rhizoma Sparganii and Curcumae rhizoma can be added for treating coronary heart disease, with a treatment course of 3-12 months;

rhizoma Alismatis and herba Lycopi can be added for improving heart failure, with treatment course of 2-6 months;

morinda officinalis has better curative effect on depression, and the treatment course is 2-3 months;

radix Puerariae can be added for treating cervical spondylosis, with treatment course of 2-3 weeks

Eucommia bark and achyranthes root are added, so that the curative effect on lumbar spondylosis is better, and the treatment course is 2-3 weeks;

rhizoma corydalis has better effect on arrhythmia, and the treatment course is 2-3 months;

poria with hostwood is more beneficial to relieving insomnia, and the treatment course is 2-3 weeks;

the albizia julibrissin and the radix curcumae are added, so that the insomnia can be relieved, and the treatment course is 2-3 weeks;

honey-added ephedra or raw ephedra is added, so that the treatment course has better curative effect on the bradyarrhythmia for 4 weeks;

colla Corii Asini can be added to achieve good therapeutic effect for miscarriage prevention, with a treatment course of 4-12 weeks;

the angelica and the white peony root are added, so that the curative period of treatment for blood deficiency is better for 4 weeks;

rhizoma Wenyujin Concisa is added, so that the treatment course has better curative effect on shoulder and back pain for 4 weeks;

herba asari can be added to achieve better analgesic effect for 4 weeks;

cinnamon has better curative effect on dysmenorrheal, and the treatment course is 4 weeks;

the lycopodium clavatum has better curative effect on muscle spasm for 4 weeks;

dogwood has a better curative effect on tonifying liver and kidney, and the treatment course is 4 weeks;

prepared rehmannia root has better curative effect on nourishing liver and kidney, and the treatment course is 4 weeks;

dried rehmannia root, which has better curative effect on liver and kidney and has a treatment course of 4 weeks;

the pangolin scales have better curative effect on promoting blood circulation and removing obstruction in channels for 4 weeks;

the tortoise plastron has better curative effect on nourishing liver and kidney for 4 weeks;

turtle shell has better curative effect on nourishing liver and kidney and promoting blood circulation for 4 weeks;

the codonopsis pilosula has a better curative effect on strengthening the spleen, and the treatment course is 4 weeks;

ginseng, the treatment course with better curative effect on tonifying qi is 4 weeks;

pseudo-ginseng has better curative effect on promoting blood circulation and removing blood stasis, and the treatment course is 4 to 24 weeks;

the areca peel has better curative effect on treating the gastroenteritis for 4 weeks;

clematis root has better curative effect on pain and gout for 4 weeks;

leeches have better curative effect on promoting blood circulation to remove blood stasis and treating cardiovascular diseases, and the treatment course is 4-12 weeks;

the scorpion has better curative effect and treatment course for relieving pain for 4 weeks;

centipede; the treatment course has better curative effect on relieving pain for 4 weeks; (ii) a

Cortex Albizziae has better curative effect on insomnia, and the treatment course is 4 weeks;

the spina date seed has better curative effect on insomnia, and the treatment course is 4 weeks;

the immature bitter orange has better curative effect on treating the gastroenteritis for 4 weeks;

gynostemma pentaphylla, which has a better curative effect on hyperlipidemia for 4 weeks;

buxine, has better curative effect on arrhythmia for 4 weeks;

aster, which has better curative effect on cough for 4 weeks; (ii) a

The antler glue has better curative effect on tonifying the kidney and treating the blood diseases, and the treatment course is 12 weeks;

the tortoise plastron glue has better curative effect on tonifying the kidney and treating the blood diseases, and the treatment course is 12 weeks;

peach kernel, which has better curative effect for promoting blood circulation and removing blood stasis for 12 weeks;

earthworm has better curative effect on cardiovascular diseases, and the treatment course is 12 weeks;

the semen hoveniae has better curative effect on treating liver diseases, and the treatment course is 12 weeks;

the dodder has better curative effect on tonifying the kidney and treating the blood diseases, and the treatment course is 12 weeks;

cynomorium songaricum has better curative effect on tonifying kidney and treating hematopathy, and the treatment course is 12 weeks;

the diaphragma juglandis has better curative effect and treatment course for senile urinary incontinence for 4 weeks;

according to clinical use cases, the multi-indication traditional Chinese medicine composition can also be mixed with wrinkled giant hyssop and eupatorium; fructus Lycii and herba Epimedii; morinda officinalis and epimedium; garden burnet and sophora fruit; aster and coltsfoot; radix Adenophorae and radix Ophiopogonis; ephedra and almond; ephedra and almond; astragalus root; rhizoma Gastrodiae; largehead atractylodes rhizome; pinellia ternata; cistanche deserticola; clove and calyx kaki; poria, rhizoma Alismatis, flos Magnoliae, and fructus Xanthii; flos Inulae and Haematitum; albizzia flower; radix astragali, fructus Ligustri Lucidi and fructus Psoraleae or Carthami flos and herba Leonuri to obtain formulas with different side effects.

The product of the traditional Chinese medicine composition claimed by the invention can be prepared into any preparation form by adopting the conventional technical means in the field, and comprises various required preparation forms by adopting some conventional auxiliary materials.

In the embodiment of preparing Chinese patent medicine, the Chinese patent medicine is preferably prepared into oral decoction, powder, granules or pills. But is not limited thereto.

The raw material medicines adopted in all schemes of the invention can be purchased in a common traditional Chinese medicine pharmacy, wherein the brief introduction of part of the raw material medicines is as follows:

honey-fried licorice root: (RADIX Glycyrrhiza PREPARATA), which is a leguminous plant, honey-baked licorice root is prepared by putting honey into a pot, refining the honey into medium honey, adding raw licorice root slices with slow fire, uniformly stirring and frying, taking out of the pot for 3-5 min, putting the pot in a baking room or an oven 60-C, taking out when the honey is not sticky, and cooling. Licorice, academic name: glycyrrhiza uralensis Fisch, Leguminosae and liquorice belong to perennial herbs, the medicinal parts are roots and rhizomes, and the medicinal root is cylindrical, 25-100 cm in length and 0.6-3.5 cm in diameter. The honey-fried licorice decoction has the treatment effects of tonifying qi, nourishing yin, activating yang and recovering pulse.

Chinese date: has the functions of nourishing yin, tonifying yang and enriching blood

Dried ginger: is dried rhizome of Zingiber oj-jicinale Rosc. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung and resolving fluid retention.

Red ginseng: is prepared from Ginseng radix of Araliaceae by soaking, cleaning, sorting, steaming, air drying, and oven drying. During steaming, the red ginseng has chemical reaction and weight change due to heat treatment, and has effects of invigorating qi, nourishing yin, nourishing blood, promoting fluid production, tonifying heart, invigorating stomach, and tranquilizing mind.

Frying the bighead atractylodes rhizome: is a processed product of largehead atractylodes rhizome, and the processing method is approximately as follows: spreading the honey-fried bran into a hot pot, adding Atractylodis rhizoma tablet when smoking, parching to brown, and removing the burnt smell, taking out, and sieving to remove the honey-fried bran. Atractylodes macrocephala, the academic name of Latin, Atractylodes macrocephala, belongs to perennial herb of Compositae and Atractylodes. The rhizome is used as a medicine and has multiple medicinal functions. Has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage, and can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm and fluid retention, dizziness, edema, spontaneous perspiration, and threatened abortion.

Tuckahoe, poria cocos: is dried sclerotium of Wolf of Poria cocos (Schw.) Cos (belonging to family Polyporaceae). It is commonly indicated for edema, oliguria, dizziness and palpitation, spleen deficiency, poor appetite, loose stool and diarrhea, uneasiness, palpitation and insomnia etc. due to heart, lung, spleen and kidney.

Herba schizonepetae: alias: herba Schizonepetae, herba Capsellae, herba Artemisiae Annuae, and herba Stachydis Japonicae are perennial plants of genus Schizonepetae of family Labiatae. Used as medicine for its dried stem and leaf and flower spike.

Wind prevention: root of Saposhnikovia divaricata of Umbelliferae.

Red yeast rice: is prepared from long-shaped rice as raw material by separating high-quality Monascus purpureus by modern bioengineering technology, and refining by liquid submerged fermentation, and is a natural food additive with high safety and beneficial to human health

Three-edge: is a dried tuber of Sparganium stoloni erum, Buch. -ham. belonging to the family Sparganium.

Curcumae rhizoma; is dried rhizome of Curcuma zedoaria Curcuma phaeocaulis Val, Curcuma Kwangsiensis S.G.Lee et C.F.Liang or Curcuma wenyujin Y.H.Chen et C.Ling

Rhizoma alismatis: perennial aquatic or marsh grass.

Herba lycopi: is the dry aerial part of the seedling of the sweet potato or the seedling of the hairy sweet potato of the Labiatae family.

Turmeric root-tuber: is dried root tuber of Curcuma wenyuma Curcuma wenyujin Y, H.Chenet C.Ling, Curcuma longa LongaL, Curcuma kwangmakuwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria Curcuma phaeocauli Val.

Morinda officinalis: the name learning: morinda officinalis How, which is a dried root of the plant Morinda officinalis of the family Rubiaceae of the dicotyledonous plant.

Herba epimedii: the name learning: whole plant of perennial herbaceous plant of epicedium brevicornum maxim.

Kudzu root: is dried root of Pueraria lobata Ohwi of Leguminosae

Agastache rugosus: belonging to order Labiatae, a perennial herb of the family Labiatae, also known as: herb of Hexiang, rhizoma Atractylodis Macrocephalae, and fructus Foeniculi.

Herba Eupatorii: the Latin school name Eupatorium aponic Turcz is Eupatorium fortunei (Eupatorium fortunei) of Compositae, and is used as a whole herb.

Root of straight ladybell: latin learning name: adenophora stricta Miq. ], perennial herb of Adenophora of Campanulaceae, root of which is used as a drug.

Radix ophiopogonis: ophiopogon japonicus (scientific name, Ophiopogon aponicas (Linn.F.) Ker-Gawl.) root tuber of perennial evergreen herbaceous plant of the genus Ophiopogon of the family Liliaceae.

Persimmon calyx: is dried persistent calyx of Diospyros kaki Thunb of Ebenaceae

Poria with hostwood: the root of white poria is surrounded by the root of Pinus massoniana.

And (3) magnolia flower: flower bud of Magnolia flower.

Fructus xanthil: fruit with involucre of Xanthium strumarium belonging to Compositae and Xanthium annual herbaceous Compositae.

And (3) inula flower: inula flower of Compositae, also known as: herba Inulae, flos Lonicerae, Didijin, fructus maltreat, summer chrysanthemum, and mulberry, drying flowers for administration.

Haematitum: an oxide mineral hematite ore.

Garden burnet root: latin learning name: sanguisorba officinalis l. is the root of a perennial herb of the genus Sanguisorba of the family rosaceae.

And (3) pod of Chinese scholartree: dried flower, flower bud, and mature fruit of Sophora japonica L.

Rhizoma corydalis; corydalis tuber (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), also known as: corydalis tuber, etc. Is tuber of perennial herb of family Papaveraceae, genus Viola.

Safflower: safflower, (Latin scientific name: Carthamus tinctorius L.), alias: the dried tubular flowers of the plants of the genus Carthamus and the family Compositae are used as the medicine.

Glabrous greenbrier rhizome: is dried rhizome of Smilax scobinicaulis C.Y. Smith of Liliaceae

Aster root: the name learning: astertataricus l.f., alias: radix asteris, purple wonder, braid and the like; root stock of perennial herb belonging to Aster genus of Compositae family.

Coltsfoot: is the flower bud of coltsfoot (Tussilago farfara L.) of coltsfoot of Compositae.

Herba ephedrae: dried grass stem of Ephedra sinica, Ephedra sinica or Ephedra equiseti of Ephedraceae

Shooting; is a Belamcanda chinensis (L.) Redout Wen perennial herbaceous rootstock.

Detailed Description

The preparation method and clinical efficacy of the Chinese medicinal composition and the product thereof are described in the following by specific embodiments

Examples 1-79 prescription and preparation of Compound soup

TABLE 1 formulation of the reduction soup of examples 1-79

The preparation method of the decoction comprises the following steps:

(1) the raw materials were prepared according to the formulations listed in Table 1

(2) Adding 800 ml of water into each dose of the medicine every time, and decocting the medicine for 30 minutes by slow fire;

(3) adding water for 1-2 times, and mixing decoctions to obtain oral decoction.

Note: when one dose of the medicine is mentioned in the invention, taking the example 1 as an example, the one dose of the medicine is equivalent to an oral product prepared by taking 10-30g of honey-fried licorice root, 6-15g of red ginseng, 6-15g of fried bighead atractylodes rhizome and 6-15g of dried ginger as raw material medicines. The rest of the examples are analogized.

Clinical experimental examples:

the drugs of examples 1-78 were recorded for clinical medication.

The statistical results show that the Chinese medicinal compositions of examples 1 to 6 have significant curative effects on a plurality of diseases, and the clinical observation statistics are shown in the following table 2:

TABLE 2 Observation statistics of clinical Experimental examples

The numerical points between the value ranges of the weight parts of the medicines in the formula 1-6 in Table 2 are used in the prescription of outpatient treatment, for example, 0.6-1.5 parts by weight of red ginseng, which means that 0.6 part by weight, 0.7 part by weight, 0.8 part by weight, 0.9 part by weight, 1 part by weight, 1.1 part by weight, 1.2 parts by weight, 1.3 parts by weight, 1.4 parts by weight, and 1.5 parts by weight are effective clinical practice examples;

the same applies to the range of values for the remaining raw materials, and different values within this range have been adopted during several outpatient treatments, depending on the degree of symptoms.

In some embodiments, the amount of the component D, namely dried ginger, baked ginger or poria cocos, is zero.

On the basis of the multi-effect traditional Chinese medicine composition of the embodiments 1 to 6, the inventor selectively adds different auxiliary raw material medicines aiming at different symptoms, so that the effect of the observation and recovery decoction of the invention is more obvious and targeted, and cure statistics of part of clinical observation cases are as follows in the following table 3:

TABLE 3 clinical efficacy statistics of guanfu decoction derived formulations

In conclusion, clinical observation and statistics show that the multi-indication traditional Chinese medicine composition provided by the invention is a miscarriage-removing and middle-regulating decoction, but the multi-indication traditional Chinese medicine composition has wider indications than the middle-regulating decoction, is mild and safe in efficacy, and can be taken by all people except patients with severe yin deficiency and patients with simple excess heat syndrome; on the other hand, on the basis of the multifunctional traditional Chinese medicine composition, a proper amount of raw material medicines corresponding to symptoms are added, so that a targeted medicine formula which has a remarkable curative effect and aims at different diseases is obtained.

Claims

1. The basic unit of the medicine for combining the medicines with different efficacies is characterized by consisting of 2 to 3 weight parts of a raw material medicine A, 0.6 to 1.5 weight parts of a raw material medicine B, 0.6 to 1.5 weight parts of a raw material medicine C and 0 to 1.5 weight parts of a raw material medicine D;

the raw material medicine A is Chinese date;

the raw material medicine B is red ginseng;

the raw material medicine C is fried bighead atractylodes rhizome;

the raw material medicine D is dried ginger.

2. A traditional Chinese medicine composition is obtained by adding any one of the following auxiliary raw material medicines on the basis of the basic medicine unit of claim 1:

0.6 to 1.5 weight portions of rhizoma corydalis;

0.6 to 1.5 portions of red yeast;

0.6 to 1.5 weight parts of morinda officinalis;

0.6 to 1.5 weight portions of poria with hostwood;

0.6 to 1.5 weight parts of albizia flower and 0.6 to 1.5 weight parts of radix curcumae;

0.8 to 1.2 portions of kudzu root;

0.6 to 1.5 weight parts of eucommia bark and 0.6 to 1.5 weight parts of achyranthes root.

3. A Chinese medicinal preparation having therapeutic effects on various disorders, which is prepared from the pharmaceutical basic unit of claim 1 or the Chinese medicinal composition of claim 2.

4. The traditional Chinese medicine product of claim 3, further comprising acceptable excipients for preparing a desired dosage form.

5. The Chinese medicinal preparation according to claim 4, wherein the dosage form is oral decoction, powder, granule, or pill.

6. The method of any one of claims 3-5, wherein the step of preparing comprises decocting the raw materials to obtain an aqueous herbal extract.

7. The method of claim 6, wherein the preparing step comprises decocting the red ginseng for at least 15 minutes, and then adding the rest materials to the decoction.

8. A basic unit of medicine and pharmaceutical use of Chinese medicinal composition comprising basic unit of medicine in preparing different effects medicament, wherein said basic unit of medicine is made up of bulk drug A of 2-3 weight shares, bulk drug B of 0.6-1.5 weight shares, bulk drug C of 0.6-1.5 weight shares and bulk drug D of 0-1.5 weight shares;

the raw material medicine A is Chinese date;

the raw material medicine B is red ginseng;

the raw material medicine C is fried bighead atractylodes rhizome;

the raw material medicine D is dried ginger;

the drug base unit is effective in treating hyperthyroidism and hypertension;

the traditional Chinese medicine composition containing the basic unit of the medicine comprises the following components:

0.6 to 1.5 weight parts of rhizoma sparganii and 0.6 to 1.5 weight parts of rhizoma zedoariae are added on the basis of the basic unit of the medicine, thus effectively treating coronary heart disease;

0.6 to 1.5 weight parts of rhizoma corydalis is added on the basis of the basic medicinal unit, so that arrhythmia is effectively treated;

0.6 to 1.5 weight parts of alisma orientale and 0.6 to 1.5 weight parts of eupatorium japonicum are added on the basis of the basic unit of the medicine, so that the heart failure is effectively treated;

0.6 to 1.5 weight parts of red yeast rice is added on the basis of the basic medicinal units, so that the hyperlipidemia can be effectively treated;

0.6-1.5 parts by weight of morinda officinalis is added on the basis of the basic medicinal units, so that depression is effectively treated;

0.6 to 1.5 weight parts of poria with hostwood or 0.6 to 1.5 weight parts of albizia flower and 0.6 to 1.5 weight parts of radix curcumae are added on the basis of the basic medicinal units, so that insomnia is effectively treated;

0.6 to 1.5 weight parts of schizonepeta and 0.6 to 1.5 weight parts of divaricate saposhnikovia root are added on the basis of the basic medicinal units, so that the rash and the eczema are effectively treated;

0.8-1.2 parts by weight of kudzu root is added on the basis of the basic units of the medicine, so that cervical spondylosis is effectively treated;

on the basis of the basic medicinal units, 0.6-1.5 parts by weight of eucommia ulmoides and 0.6-1.5 parts by weight of achyranthes bidentata are added, so that lumbar spondylosis is effectively treated.

9. The pharmaceutical use according to claim 8, wherein the pharmaceutical basic unit consists of 2 parts by weight of the drug substance A, 1 part by weight of the drug substance B, 1 part by weight of the drug substance C and 1 part by weight of the drug substance D.