CN104138341A - Preparation method of qi tonifying, whitening and bacterium inhibiting mask - Google Patents
Preparation method of qi tonifying, whitening and bacterium inhibiting mask Download PDFInfo
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- CN104138341A CN104138341A CN201310169277.2A CN201310169277A CN104138341A CN 104138341 A CN104138341 A CN 104138341A CN 201310169277 A CN201310169277 A CN 201310169277A CN 104138341 A CN104138341 A CN 104138341A
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- invigorating
- tonifying
- rhizoma atractylodis
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Abstract
The invention discloses a preparation method of a qi tonifying, whitening and bacterium inhibiting mask. The mask is composed of an extract obtained after extracting four traditional Chinese medicines, 5.5-6.5g of polyvinyl alcohol AH-26 and 3.7-4.3mL of glycerin, and contains no sorbic acid, the four traditional Chinese medicines comprise 9g of Rhizoma Atractylodis Macrocephalae, 9g of ginseng, 9g of Poria cocos and 6g of licorice root, and the extract is obtained through the steps of adding 250mL of 45% ethanol (diluted with 98% ethanol), carrying out reflux extraction for 2h, carrying out pumping filtration, evaporating in a constant temperature water-bath tot dryness and no ethanol smell, and concentrating to obtain the extract. Additives are obtained by optimizing through an orthogonal test design. Ginseng in the above prescription is used as a monarch medicine, and has a dry temperature qi tonifying effect. Rhizoma Atractylodis Macrocephalae is used as a minister medicine, has bitter warm qi tonifying reinforcement effect, and also has a bacterium inhibiting efficacy; slightly sweet Poria cocos is used as an assistant medicine, has spleen invigorating and dampness excreting effects, and the cooperation of Poria cocos with Rhizoma Atractylodis Macrocephalae realizes substantial spleen invigorating and dampness dispelling efficacies. Honey-fried licorice root is used as a guide medicine, can tonity qi, harmonize the middle warmer and regulate many medicines, has different bacterium inhibition effects on two common pathogens, and has obvious bacterium inhibition effects. The qi tonifying, whitening and bacterium inhibiting effects of the mask are finally reached.
Description
Technical field
The invention belongs to cosmetics and health product manufacture field, relate to the preparation of the antibacterial facial film of a kind of QI invigorating whitening.
Background technology
According to learning in obtained documents and materials, although existing many about the research of this taste medicine of the Rhizoma Atractylodis Macrocephalae, be the research to its effective ingredient mostly, therefore select the compound recipe Rhizoma Atractylodis Macrocephalae to there is certain researching value for experimental subject.
Facial film is a kind of a kind of preparation that contacts skin and absorb by skin permeation administration, facial film is applicable to the complex situations of Chinese medicine compound multicomponent compatibility, can hold Chinese medicine extract and superfine medicated powder simultaneously, adapt to the condition of production of Chinese medicine compound medicining condition and preparation, also easy to utilize.In the Chinese herbal medicine resource of China's abundant, medicinal plants kind approximately has 11020 kinds, and cleawhite pack is many in the market, but seldom sees the facial film that has QI invigorating fungistatic effect concurrently, has also seldom done antibacterial, antibacterial activity research.Plant is the natural treasure-house of bioactive compound, and the secondary metabolite of its generation exceedes 400,000 kinds, and in Chinese herbal medicine, most of materials all have antibacterial, antibacterial or bactericidal activity as alkaloid, flavonoid, steroidal, phenols, unique aminoacid and polysaccharide etc.At present, relevant Chinese herbal medicine insecticide active substance research is more deep, and Chinese herbal medicine is antibacterial, the research of sterilization aspect is relatively less.
Summary of the invention
The product of the present invention's research and development is intended to by the effect of herbal mixture pharmacology, and in side, Radix Ginseng is monarch, dry warm QI invigorating, strengthening the spleen and nourishing the stomach.Minister is with the bitter using warming therapy Rhizoma Atractylodis Macrocephalae, and the spleen strengthening and damp drying is strengthened QI invigorating and help the power of fortune; Help with sweet light Poria, spleen invigorating eliminating dampness by diuresis, Siberian cocklebur, art match, the merit of invigorating the spleen to clear away damp pathogen benefit work.Make with Radix Glycyrrhizae Preparata, QI invigorating and in, coordinating the actions of various ingredients in a prescription.Four medicine compatibilities, the merit of playing altogether replenishing QI to invigorate the spleen.Develop a kind of face mask of traditional Chinese medicine with QI invigorating whitening bacteriostasis, used modern pharmacological methods to verify effect of this facial film.
The present invention takes following measures:
1. formulation, by By consulting literatures data, record has the Chinese herbal medicine of QI invigorating whitening effect.And formulate multiple may tool medicative formula.As Radix Ginseng, effect of the Rhizoma Atractylodis Macrocephalae.
2. selected rational formula
From multiple formulas, determine the most effective and reasonable formula.
3. facial film preparation
In the face mask of traditional Chinese medicine of QI invigorating whitening bacteriostasis, each raw material of Chinese medicine medicine and weight proportion thereof are as follows:
4 taste Chinese medicines comprise the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, the each 9g of Poria, Radix Glycyrrhizae 6g.Each raw material of Chinese medicine medicine all needs through pulverizing, and crosses sieve No. 5-7, and then the leaching process of extractum is as follows: add 45% ethanol 250mL (by 98% ethanol dilution), put in 500mL round-bottomed flask reflux, extract, 2h, sucking filtration, in water bath with thermostatic control, evaporate to dryness, to without ethanol taste, is condensed into thick paste.Adjuvant is preferably obtained by Orthogonal Experiment and Design.
Detailed description of the invention
Below in conjunction with detailed description of the invention, summary of the invention of the present invention is described in further detail.
The antibacterial each raw material of Chinese medicine medicine of facial film and the weight proportion thereof of QI invigorating whitening is as follows:
The Rhizoma Atractylodis Macrocephalae, Radix Ginseng, the each 9g of Poria, Radix Glycyrrhizae 6g.
Each raw material of Chinese medicine medicine all needs through pulverizing, and crosses sieve No. 5-7.
Extractum leaching process is as follows: add 45% ethanol 250mL (by 98% ethanol dilution), and reflux, extract, 2h, sucking filtration, in water bath with thermostatic control, evaporate to dryness, to without ethanol taste, is condensed into thick paste.
Adjuvant is preferably obtained by Orthogonal Experiment and Design.On the basis of documents and materials and trial test, taking polyvinyl alcohol AH-26 as substrate, taking the film formation time of liniment, presentation quality as index, optimize the formulation and technology of liniment.Adopt orthogonal design, select consumption, the glycerol consumption of the principal element polyvinyl alcohol AH-26 that affects liniment, 3 factors of consumption of sorbic acid, 3 levels of each factor are carried out preferably, factor level arrangement (in table 1).
Table 1 factor level table
Table1?Factor?level?table
Orthogonal experiment results (in table 2).Measure the film formation time of each test specimen according to official method, and its appearance index (comprising viscosity, moulding property, uniformity, tearable) is carried out to comprehensive grading with ten point system.As shown in Table 2, taking film formation time as investigating index, extreme difference R value size shows that each factor is followed successively by film formation time influence degree: A > C > B, wherein with polyvinyl alcohol AH-26, film formation time is had the greatest impact, and more with polyvinyl alcohol AH-26 consumption, film formation time is longer; Taking the presentation quality of liniment as investigating index, extreme difference R value size shows that each factor is followed successively by presentation quality influence degree: C > B=A, and C factor affects presentation quality maximum, and sorbic acid consumption is fewer, film outward appearance is better, taking need not be as good.Because film formation time is better than presentation quality, and in clinical practice, should shorten the film formation time of liniment, principle determines that each factor is followed successively by the influence degree of extraction effect accordingly: A > C > B as far as possible; Best prescription is: polyvinyl alcohol AH-266g, glycerol 4mL, does not use sorbic acid.
Table 2 orthogonal experiments
Table2?Orthogonal?test
Table 2: orthogonal experiments
Table2：Orthogonal?test
And carried out the extracorporeal bacteria inhibitor test to encountered pathogenic bacteria, specific as follows:
The preparation of beef-protein medium: take respectively peptone 10g, Carnis Bovis seu Bubali cream 3g, sodium chloride 5g agar powder 15g, get the water that is less than total amount in beaker, by each medium component (except agar) add be one by one right treat molten, use slow fire heating for dissolving, and constantly stir, after dissolving, be settled to 1000mL.The beef extract-peptone culture fluid just preparing is slightly acidic, therefore need to adjust pH to 7.2-7.4 with NaOH solution, regulates its pH-value with PH reagent paper.The culture medium preparing is divided in corresponding triangular flask, adds tampon, wrapping triangular flask.Pressurization autoclave 2h will be put into the culture medium of sterilizing.Storage, for culture of bacteria.
The preparation of bacteria suspension: will move in the corresponding test tube slant of access culture medium for examination strain, escherichia coli, staphylococcus aureus are put in 36-37 DEG C of constant incubator and cultivate 24h, with a little thalline of inoculating loop picking, in physiological saline solution being housed in vitro, vibrations evenly, are made bacteria suspension., be for examination bacteria suspension the dilution of bacterium liquid with dilution method.
Adopt agar borehole culture method: first in aseptic plate, add the agar culture medium 20mL having melted as bottom, after solidifying, add again to contain and cultivate 18-24h experimental bacteria liquid broth agar culture medium 4-5mL and be layered on above-mentioned bottom, after solidifying, in every plate, evenly burrow 3 with the aseptic grommet device of diameter 6-12mm, remove agar in hole, pour into tested medicinal liquid, sealing, put cultivation 24h in 37 DEG C of calorstats, result to be seen, if there is antibacterial action, there is the area of asepsis growth in hole week, claim inhibition zone to record the diameter of inhibition zone, with symbol "-", "+", " ++ ", " +++ " represents antibacterial intensity.
Result (in table 3) tested number 1,2,3 is colibacillary 3 groups of parallel tests, 3 groups of parallel tests that tested number 5,6,7 is staphylococcus aureus, and tested number 4,8 is not for adding the matched group of medicine.
Table 3 bacteriostatic test result
Table3?Antibacterial?test?results
Put in 37 DEG C of calorstats and cultivate after 24h, respectively in the antibacterial result of first day, second day, the 3rd day, the 5th day, the 7th day viewing test.Table 3 shows: tested number 1,2, and 3 have shown obvious fungistatic effect, and tested number 4, for blank experiment shows as without fungistatic effect, has obvious fungistatic effect therefore experimental result shows the extracting solution of the compound recipe Rhizoma Atractylodis Macrocephalae to escherichia coli, and antibacterial intensity is " +++ "; Tested number 5,6,7 have also shown fungistatic effect, and tested number 8, for blank experiment shows as without according to effect, has obvious fungistatic effect therefore experimental result shows the extracting solution of the compound recipe Rhizoma Atractylodis Macrocephalae to staphylococcus aureus, and antibacterial intensity is " ++ ".
Figure is that the side of the antibacterial facial film of QI invigorating whitening separates and prepares sketch.
Claims (5)
1. a preparation method for the antibacterial facial film of QI invigorating whitening, extractum and the polyvinyl alcohol AH-265.5-6.5g of the present invention after by 4 taste Chinese medicine extraction, glycerol 3.7-4.3mL, does not use sorbic acid composition.
2. the antibacterial each raw material of Chinese medicine medicine of facial film and the weight proportion thereof of QI invigorating whitening according to claim 1 is as follows: the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, the each 9g of Poria, Radix Glycyrrhizae 6g.
3. the each raw material of Chinese medicine medicine of the antibacterial facial film of QI invigorating whitening according to claim 1 all needs through pulverizing, and crosses sieve No. 5-7.
4. in the antibacterial facial film of QI invigorating whitening according to claim 1, extractum leaching process is as follows: add 45% ethanol 250mL, and reflux, extract, 2h, sucking filtration, in water bath with thermostatic control, evaporate to dryness, to without ethanol taste, is condensed into thick paste.
5. measure the film formation time of each test specimen with reference to official method according to adjuvant claimed in claim 1, and its appearance index (comprising viscosity, moulding property, uniformity, tearable) is carried out comprehensive grading and obtained, the proportioning of thick paste and adjuvant is the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, the each 9g of Poria, Radix Glycyrrhizae 6g concentrated and thick paste and polyvinyl alcohol AH-265.5-6.5g, glycerol 3.7-4.3mL, does not use sorbic acid composition.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105520881A (en) * | 2016-01-18 | 2016-04-27 | 罗美香 | Whitening and moisturizing facial mask used in winter |
| WO2017181988A1 (en) * | 2016-04-21 | 2017-10-26 | 张东 | Traditional-chinese-medicine composition effective in treating various conditions, and derivative thereof and product thereof |
| CN109431887A (en) * | 2018-08-07 | 2019-03-08 | 湖南炎帝生物工程有限公司 | A kind of beauty bazhen decoction extracting solution and its preparation method and application |
| CN114869831A (en) * | 2022-05-26 | 2022-08-09 | 江苏巴帝恩生物科技有限公司 | A method for preparing cosmetic composition containing natural plants |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475647A (en) * | 2010-11-23 | 2012-05-30 | 刘世超 | Ginseng mask |
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2013
- 2013-05-06 CN CN201310169277.2A patent/CN104138341A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475647A (en) * | 2010-11-23 | 2012-05-30 | 刘世超 | Ginseng mask |
Non-Patent Citations (4)
| Title |
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| 刘程等编: "《表面活性剂应用手册》", 30 September 2004 * |
| 南京中医药大学编著: "《中药大辞典》", 31 March 2006 * |
| 周德生、何清湖总主编: "《<医方论>释义》", 28 February 2013 * |
| 朱晓平编: "《很老很老的老偏方，女人烦恼一扫光》", 31 December 2011 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105520881A (en) * | 2016-01-18 | 2016-04-27 | 罗美香 | Whitening and moisturizing facial mask used in winter |
| WO2017181988A1 (en) * | 2016-04-21 | 2017-10-26 | 张东 | Traditional-chinese-medicine composition effective in treating various conditions, and derivative thereof and product thereof |
| CN109431887A (en) * | 2018-08-07 | 2019-03-08 | 湖南炎帝生物工程有限公司 | A kind of beauty bazhen decoction extracting solution and its preparation method and application |
| CN114869831A (en) * | 2022-05-26 | 2022-08-09 | 江苏巴帝恩生物科技有限公司 | A method for preparing cosmetic composition containing natural plants |
| CN114869831B (en) * | 2022-05-26 | 2024-04-30 | 江苏巴帝恩生物科技有限公司 | A method for preparing cosmetic composition containing natural plants |
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Application publication date: 20141112 |
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