CN108261505A - A kind of drug of logical stalkization bolt and preparation method thereof - Google Patents
A kind of drug of logical stalkization bolt and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of drugs of logical stalkization bolt and preparation method thereof, and by the raw material of following weight, routinely oral solutions are made in formulation method：15 ~ 50 parts of Radix Astragali, 10 ~ 40 parts of Radix Salviae Miltiorrhizae, 10 ~ 30 parts of hawthorn, 8 ~ 32 parts of gynostemma pentaphylla, 2 ~ 30 parts of radix cyathulae, 2 ~ 30 parts of Caulis Spatholobi, 2 ~ 20 parts of Rhizoma Et Radix Notopterygii, 1 ~ 15 part of frankincense, 1 ~ 15 part of myrrh, 2 ~ 25 parts of peach kernel, 2 ~ 25 parts of safflower, 2 ~ 25 parts of cassia twig, 2 ~ 25 parts of ramulus mori, 2 ~ 25 parts of the radix paeoniae rubrathe, 2 ~ 18 parts of Rhizoma Chuanxiong, 2 ~ 18 parts of Radix Angelicae Sinensis, 2 ~ 20 parts of earthworm, 2 ~ 30 parts of Rhizoma Gastrodiae, 5 ~ 35 parts of uncaria, 4 ~ 30 parts of selfheal, 2 ~ 18 parts of leech, 2 ~ 30 parts of Common St.Paulswort Herb, 2 ~ 30 parts of Cortex Eucommiae, 2 ~ 25 parts of Ramulus Taxilli.Drug of the present invention is through clinically hundred case observation verifications, the results showed that, treatment hypertension, cerebral infarction total effective rate are 97.5%, and cure rate is high, and treatment cycle is short, without any side effects to human body, use easy to spread.
Description
Technical field
The invention belongs to field of Chinese medicinal composition, and in particular to a kind of drug of logical stalkization bolt.
Background technology
Hypertension, cerebral infarction are human body common diseases, and the pathogenesis under theory of traditional Chinese medical science is：Qi being the governor of blood, blood are gas
Mother, after more than illness is due to human body apoplexy, healthy tendency virtual loss, blood stagnancy due to deficiency of QI, caused by venation block, healthy tendency virtual loss, and cannot
Promoting circulation of blood, so that venation block, tendon and vessel muscle, which loses, to be supported, blood stagnation, smooth slow, makes blood supply in brain insufficient, in the course of time
Blood stasis is formed, blood pressure raising then generates infraction, thrombus, therefore sees hemiplegia, the clinical manifestations such as facial paralysis.
The traditional Chinese medical science thinks that the occurrence and development process of any disease is all since pathogenic factor acts on human body, causes body cloudy
Positive contain partially is declined partially, the result of zang-fu differentiation malfunction；The basic principle that traditional Chinese medicine disease prevention is cured the disease：Eliminating evil is gone because strengthening the body resistance to consolidate the constitution, assisting
Adjust zang-fu differentiation function, so as to correct it is yin or yang excess decline partially, make body recovery to the normal condition of yin and yang in equilibrium.
Doctor trained in Western medicine thinks that hypertension, cerebral infarction are a kind of symptoms of organ ischemia's property necrosis, are mainly in 50~60 years old or more
Crowd, the death rate is high, often has atherosclerosis, hypertension, has premonitory symptom more before onset, and clinical manifestation is facial paralysis,
Hemiplegia is slobbered, rice grain of eating, and lifts motionless chopsticks, the symptoms such as headache, dizziness, transience extremity numbness, which rises
Sick general relatively slow, patient onset, most of patients symptom mostly in quiet and sleep reach through a few houres even 1~3 day state of an illness
Peak.
The common Western medicine of clinical treatment hypertension has blood pressure decreasing capsule, three essences to take charge of happy piece, Indapamide, decompression No. 0 etc. at present,
Chinese medicine has Duzhong Jiangya Tablets, Niuhuang Jiangya piece etc., these western medicines in treatment hypertension are all long medication time, once be discontinued
Blood pressure can increase again, rebound again；Treatment cerebral infarction Western medicine have Betahistine Hydrochloride oral liquid, brain protein hydrolysate tablet and
Aspirin enteric coated tablet etc., Time of Administration will be up to 3-5 years, and treatment cycle is long, expensive, and cure rate is low, and takes for a long time
Side effect can be generated with Western medicine, damages hepatic and renal function, the Chinese medicine for the treatment of cerebral infarction has Folium Ginkgo, Danshen Tablets, cerebral ischemic, blood
Plug is logical etc., and product stability is poor, slowly effect.
Invention content
For the above-mentioned prior art the problem of and defect, a kind for the treatment of cycle of present invention offer is short, and expense is low, controls
More rate is high, and to a kind of drug of human body logical stalkization bolt without any side effects.
Technical solution is used by solving above-mentioned technical problem：A kind of drug of logical stalkization bolt, is matched by following parts by weight
Routinely oral liquid is made in formulation method to the raw material of ratio.
15 ~ 50 parts of Radix Astragali, 10 ~ 40 parts of Radix Salviae Miltiorrhizae, 10 ~ 30 parts of hawthorn, 8 ~ 32 parts of gynostemma pentaphylla, 2 ~ 30 parts of radix cyathulae, Caulis Spatholobi 2
~ 30 parts, 2 ~ 20 parts of Rhizoma Et Radix Notopterygii, 1 ~ 15 part of frankincense, 1 ~ 15 part of myrrh, 2 ~ 25 parts of peach kernel, 2 ~ 25 parts of safflower, 2 ~ 25 parts of cassia twig, ramulus mori 2
~ 25 parts, 2 ~ 25 parts of the radix paeoniae rubrathe, 2 ~ 18 parts of Rhizoma Chuanxiong, 2 ~ 18 parts of Radix Angelicae Sinensis, 2 ~ 20 parts of earthworm, 2 ~ 30 parts of Rhizoma Gastrodiae, 5 ~ 35 parts of uncaria, summer it is withered
4 ~ 30 parts of grass, 2 ~ 18 2 ~ 30 parts of Fen, Common St.Paulswort Herbs of leech, 2 ~ 30 parts of Cortex Eucommiae, 2 ~ 25 parts of Ramulus Taxilli.
Preparing the raw material of preferred weight part proportioning of drug of the present invention is：
25 ~ 40 parts of Radix Astragali, 15 ~ 35 parts of Radix Salviae Miltiorrhizae, 12 ~ 25 parts of hawthorn, 16 ~ 22 parts of gynostemma pentaphylla, 8 ~ 22 parts of radix cyathulae, Caulis Spatholobi 8 ~ 22
Part, 8 ~ 15 parts of Rhizoma Et Radix Notopterygii, 4 ~ 11 parts of frankincense, 4 ~ 11 parts of myrrh, 6 ~ 18 parts of peach kernel, 6 ~ 18 parts of safflower, 6 ~ 18 parts of cassia twig, ramulus mori 6 ~ 18
Part, 6 ~ 18 parts of the radix paeoniae rubrathe, 5 ~ 12 parts of Rhizoma Chuanxiong, 5 ~ 12 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of earthworm, 8 ~ 22 parts of Rhizoma Gastrodiae, 10 ~ 25 parts of uncaria, selfheal
10 ~ 22 parts, 5 ~ 12 8 ~ 22 parts of Fen, Common St.Paulswort Herbs of leech, 8 ~ 22 parts of Cortex Eucommiae, 6 ~ 18 parts of Ramulus Taxilli.
Preparing the raw material of optimum weight part proportioning of drug of the present invention is：
35 parts of Radix Astragali, 25 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 18 parts of gynostemma pentaphylla, 10 parts of radix cyathulae, 10 parts of Caulis Spatholobi, 9 parts of Rhizoma Et Radix Notopterygii, frankincense 5
Part, 5 parts of myrrh, 8 parts of peach kernel, 8 parts of safflower, 8 parts of cassia twig, 8 parts of ramulus mori, 8 parts of the radix paeoniae rubrathe, 6 parts of Rhizoma Chuanxiong, 6 parts of Radix Angelicae Sinensis, earthworm 9 part, day
10 parts of fiber crops, 15 parts of uncaria, 12 parts of selfheal, 6 10 parts of Fen, Common St.Paulswort Herbs of leech, 10 parts of Cortex Eucommiae, 8 parts of Ramulus Taxilli.
Drug of the present invention can be prepared into any drug for being suitable for clinically using according to conventional preparation process
Type, for example, pill, tablet, capsule, pulvis, powder, oral liquid etc..
The preferred agents dosage form of drug of the present invention is oral liquid, and preparation method is as follows：
Take seven dosage of Chinese herbal medicine of drug by weight ratio in inventive formulation（The dose of seven days）, sealed after being packed into medicine bag
Mouthful, it adds in 5000-6000ml water and impregnates 1 hour, the water then impregnated and medicine bag are packed into automatic boiling-machine, and use is civil and military
Remove slag taking liquid after fire is 45 minutes pan-fried, is packed with machine, and every bag is 200ml, and it is spare to be placed on refrigeration in refrigerator.
Effect to taste Chinese medicine each in the present invention in formula below, the compatibility relationship of formulation of drug and monarch, minister, assistant,
Make to elaborate：
Qi-blood deficiency is the pathogenic basic reason of this disease, and drug of the present invention is using the deficiency of vital energy as this, and the deficiency of blood is marks, based on tonifying Qi, promoting blood circulation
Supplemented by disperse blood stasis and dredge collateral.Radix Astragali, help vigour are reused in a kind of pharmaceutical formulation of logical stalkization bolt of the present invention, it is intended that gas foot, gas are prosperous then
Blood, then the stasis of blood goes network to lead to blood, is " monarch drug in a prescription ".
Leech blood-breaking dredging collateral disappears Disorder by the stasis of blood, adds and be apt to walk to alter with earthworm pharmacological property, dissipating blood stasis with potent drugs, can more play current whole body warp
The effect of network, ceases wind relieve the pain, and reduce blood pressure, and are " ministerial drug ".
Chinese angelica blood supplementing blood-nourishing；Rhizoma Chuanxiong is used for blood-activating and qi-promoting, and wind-expelling pain-stopping shares with Radix Angelicae Sinensis, help Radix Astragali benefiting qi and nourishing blood it
Effect；Large dosage of Radix Salviae Miltiorrhizae is promoting blood circulation and removing blood stasis, expands blood vessel, improves microcirculation, reduces blood pressure, and reduces blood viscosity, can break extravasated blood benefit
New blood；Peach kernel has dissipating blood stasis with potent drugs, the work(moisturized；Safflower is promoting blood circulation and removing obstruction in channels, stasis-dispelling and pain-killing, promoting blood circulation；Radix paeoniae rubrathe clearing heat and cooling blood, promoting blood circulation
Removing blood stasis and analgesics improves blood circulation, and sharing jointly can enhance promoting blood circulation and removing blood stasis, the effect of clearing and activating the channels and collaterals, and can reduce serum courage
Sterol；Frankincense, for promoting blood circulation and stopping pain, promoting the circulation of qi, shares Caulis Spatholobi, relaxing tendons and activating collaterals, promoting circulation of blood and enriching blood makes blood Channel Group, all diseases with myrrh
It can solve；Selfheal mass dissipating and swelling eliminating, purge the green, blood pressure lowering；Uncaria suppressing hyperactive liver for calming endogenous wind relieves the pain, blood pressure lowering；Rhizoma Gastrodiae ceases wind relieves the pain, and stabilizes liver
Sun, dispelling wind and removing obstruction in the meridians reduce blood pressure, share can suppressing liver-YANG and ceases wind relieve the pain, reduce blood pressure, control wind and first invigorate blood circulation, blood is lived wind
From going out；Cortex Eucommiae filling liver kidney, strengthening the bones and muscles, blood pressure lowering；Ramulus Taxilli wind-damp dispelling, Kidney-invigorating and tendon-reinforcing, blood pressure lowering；Common St.Paulswort Herb degrading the channel Li Guan
Section, wind-damp dispelling, blood pressure lowering, filling liver kidney can be enhanced by sharing, degrading the channel, sharp joint, the synergistic effect of blood pressure lowering；Hawthorn promoting the circulation of qi dissipates
The effect of stasis of blood, help digestion reducing blood lipid, shares and replenishes qi to invigorate the spleen with gynostemma pentaphylla, reinforcement blood activating and fat reducing, above-described Chinese medicine are altogether " assistant
Medicine ".
Radix cyathulae can promoting blood circulation and removing obstruction in channels and priming downlink in place of the lesion；Cassia twig, ramulus mori are good at wind-damp dispelling, promoting menstruation
Network can make blood circulation in limb end；Rhizoma Et Radix Notopterygii priming uplink is altogether " making medicine " in place of the lesion of head.
In order to verify Liquid drug preparation of the present invention to hypertension, the therapeutic effect of cerebral infarction, applicant will use this hair
Bright Liquid drug preparation commission Yulin City First Hospital traditional chinese medical science clinic of Shaanxi Province carries out 200 hypertension, Cerebral Infarction Patients
Clinical observation experiment, result of the test show in drug oral liquor treatment hypertension of the present invention, Cerebral Infarction Patients, recovery from illness 120
Example accounts for 60%, and effective 20 account for 10%, and effective 55 account for 27.5%, and invalid 5 account for 2.5%, total effective rate 97.5%, this hair
Bright drug can be promoted the use of clinically after State Food and Drug Administration's approval production.
Specific embodiment
With reference to embodiment, the present invention is described in more detail, but the present invention is not limited to these Examples.Experiment is used
Raw material include：Radix Astragali, Radix Salviae Miltiorrhizae, hawthorn, gynostemma pentaphylla, radix cyathulae, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, frankincense, myrrh, peach kernel, safflower, cassia twig,
Ramulus mori, the radix paeoniae rubrathe, Rhizoma Chuanxiong, Radix Angelicae Sinensis, earthworm, Rhizoma Gastrodiae, uncaria, selfheal, leech, Common St.Paulswort Herbs, Cortex Eucommiae, Ramulus Taxilli.
1 toxicity test of test example
Radix Astragali that the present invention selects, Radix Salviae Miltiorrhizae, hawthorn, gynostemma pentaphylla, radix cyathulae, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, frankincense, myrrh, peach kernel, safflower,
Cassia twig, ramulus mori, the radix paeoniae rubrathe, Rhizoma Chuanxiong, Radix Angelicae Sinensis, earthworm, Rhizoma Gastrodiae, uncaria, selfheal, leech, Common St.Paulswort Herbs, Cortex Eucommiae, Ramulus Taxilli are all normal
The Chinese medicine of rule, and Chinese medicine is made to the mode of oral liquid in the present invention, it is safe and convenient.
Acute toxicity test：Using NIH mouse 80, SPF grades, half male and half female, 16 ~ 22g of weight carries out acute toxicity examination
It tests.Mouse is randomly divided into two groups of administration group and control group, and every group 40, fasting 12h before experiment, drug of the present invention is brewed into liquid
Agent so that a concentration of 4.0g crude drugs/mL, using gastric infusion mode, gavage volume is 4.5mL/kg, and control group gives physiology salt
Water is administered 2 times, delivery time 6h, is observed continuously after administration 14 days, and record toxic reaction and the death of mouse for one day
Quantity.Result of the test shows that compared with the control group administration group mouse shows no obvious abnormalities, and experiment is observed continuously 14 days, and mouse is complete
Body situation, diet, drinking-water, body weight increase are normal.Selection put to death administration group mouse, test under microscope mouse core, liver, spleen,
In lung, stomach and the vitals such as thymus gland, show no obvious abnormalities.Therefore external used medicine acute toxicity of the present invention is low, clinical application
Safety.
Long term toxicity test：Using SD rats, weight 200g ± 10g, half male and half female.Drug of the present invention is brewed into liquor
It is tested, prepares high, medium and low three dosage groups, be 20,10,5 times of adult's clinical application amount respectively, using gastric infusion
Mode, continuous use 20 weeks, after being discontinued 4 weeks, test result shows：Drug of the present invention to the hair of rat, behavior, stool and urine,
The indexs such as weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat have no significant effect, and internal organs are virtually free from discovery
After significantly abnormal and histological indications show that medication is discontinued 4 weeks for 20 weeks, each internal organs of rat nothing is substantially change.Illustrate this
Invention external used medicine is to small toxicity after rat long-term administration, and also Non Apparent Abnormality reacts after drug withdrawal, and application is safe.
2 clinical test of test example
Using optimum weight part of the present invention match formula be：35 parts of Radix Astragali, 25 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 18 parts of gynostemma pentaphylla, river
10 parts of the root of bidentate achyranthes, 10 parts of Caulis Spatholobi, 9 parts of Rhizoma Et Radix Notopterygii, 5 parts of frankincense, 5 parts of myrrh, 8 parts of peach kernel, 8 parts of safflower, 8 parts of cassia twig, 8 parts of ramulus mori,
8 parts of the radix paeoniae rubrathe, 6 parts of Rhizoma Chuanxiong, 6 parts of Radix Angelicae Sinensis, 9 parts of earthworm, 10 parts of Rhizoma Gastrodiae, 15 parts of uncaria, 12 parts of selfheal, 6 Fen, Common St.Paulswort Herbs 10 of leech
Oral solutions are made in part, 10 parts of Cortex Eucommiae, 8 parts of Ramulus Taxilli, and clinical observation treatment has been carried out to 200 hypertension, Cerebral Infarction Patients,
41 ~ 76 years old age, result of the test show that drug oral liquor of the present invention is treated in hypertension, Cerebral Infarction Patients, fully recover 120
60% is accounted for, effective 20 account for 10%, and effective 55 account for 27.5%, and invalid 5 account for 2.5%, total effective rate 97.5%.
Instructions of taking：Liquid drug preparation of the present invention is taken orally, it is 3 times a day, half small after meal every time
When after the 200ml medicine bags for determining dress are heated oral, a month as a treatment course takes 1-6 courses for the treatment of altogether.Clinical test
In the process, patient, which should strictly observe, takes item, must not take other treatment this medicine in addition, should keep work and rest rule, drink
Eat it is light, it is happy, after taking 1-6 courses for the treatment of, after 3 months, start to pay a return visit patient every 2 months
And record test result.
Embodiment 1
A kind of preparation method of the oral solutions of logical stalkization bolt drug is as follows：
Take seven dosage of Chinese herbal medicine of drug by weight ratio in inventive formulation（Dose on the seven）, sealed after being packed into medicine bag
Mouthful, it adds in 5000-6000ml water and impregnates 1 hour, the water then impregnated and medicine bag are packed into automatic boiling-machine, and use is civil and military
Fire is packed after decocting 45 minutes with machine, and every bag is 200ml, and it is spare to be placed on refrigeration in refrigerator.
Embodiment 2
A kind of drug of logical stalkization bolt, is made of the raw material of following weight：
15 parts of Radix Astragali, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of hawthorn, 8 parts of gynostemma pentaphylla, 2 parts of radix cyathulae, 2 parts of Caulis Spatholobi, 2 parts of Rhizoma Et Radix Notopterygii, 1 part of frankincense,
1 part of myrrh, 2 parts of peach kernel, 2 parts of safflower, 2 parts of cassia twig, 2 parts of ramulus mori, 2 parts of the radix paeoniae rubrathe, 2 parts of Rhizoma Chuanxiong, 2 parts of Radix Angelicae Sinensis, 2 parts of earthworm, Rhizoma Gastrodiae 2
Part, 5 parts of uncaria, 4 parts of selfheal, 22 parts of Fen, Common St.Paulswort Herbs of leech, 2 parts of Cortex Eucommiae, 2 parts of Ramulus Taxilli.
Embodiment 3
A kind of drug of logical stalkization bolt, is made of the raw material of following weight：
25 parts of Radix Astragali, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of hawthorn, 16 parts of gynostemma pentaphylla, 8 parts of radix cyathulae, 8 parts of Caulis Spatholobi, 8 parts of Rhizoma Et Radix Notopterygii, frankincense 4
Part, 4 parts of myrrh, 6 parts of peach kernel, 6 parts of safflower, 6 parts of cassia twig, 6 parts of ramulus mori, 6 parts of the radix paeoniae rubrathe, 5 parts of Rhizoma Chuanxiong, 5 parts of Radix Angelicae Sinensis, earthworm 8 part, day
8 parts of fiber crops, 10 parts of uncaria, 10 parts of selfheal, 58 parts of Fen, Common St.Paulswort Herbs of leech, 8 parts of Cortex Eucommiae, 6 parts of Ramulus Taxilli.
Embodiment 4
A kind of drug of logical stalkization bolt, is made of the raw material of following weight：
40 parts of Radix Astragali, 35 parts of Radix Salviae Miltiorrhizae, 25 parts of hawthorn, 22 parts of gynostemma pentaphylla, 22 parts of radix cyathulae, 22 parts of Caulis Spatholobi, 15 parts of Rhizoma Et Radix Notopterygii, frankincense
11 parts, 11 parts of myrrh, 18 parts of peach kernel, 18 parts of safflower, 18 parts of cassia twig, 18 parts of ramulus mori, 18 parts of the radix paeoniae rubrathe, 12 parts of Rhizoma Chuanxiong, 12 parts of Radix Angelicae Sinensis,
15 parts of earthworm, 22 parts of Rhizoma Gastrodiae, 25 parts of uncaria, 22 parts of selfheal, 12 22 parts of Fen, Common St.Paulswort Herbs of leech, 22 parts of Cortex Eucommiae, Ramulus Taxilli 18
Part.
Embodiment 5
A kind of drug of logical stalkization bolt, is made of the raw material of following weight：
35 parts of Radix Astragali, 25 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 18 parts of gynostemma pentaphylla, 10 parts of radix cyathulae, 10 parts of Caulis Spatholobi, 9 parts of Rhizoma Et Radix Notopterygii, frankincense 5
Part, 5 parts of myrrh, 8 parts of peach kernel, 8 parts of safflower, 8 parts of cassia twig, 8 parts of ramulus mori, 8 parts of the radix paeoniae rubrathe, 6 parts of Rhizoma Chuanxiong, 6 parts of Radix Angelicae Sinensis, earthworm 9 part, day
10 parts of fiber crops, 15 parts of uncaria, 12 parts of selfheal, 6 10 parts of Fen, Common St.Paulswort Herbs of leech, 10 parts of Cortex Eucommiae, 8 parts of Ramulus Taxilli.
Embodiment 6
A kind of drug of logical stalkization bolt, is made of the raw material of following weight：
50 parts of Radix Astragali, 40 parts of Radix Salviae Miltiorrhizae, 30 parts of hawthorn, 32 parts of gynostemma pentaphylla, 30 parts of radix cyathulae, 30 parts of Caulis Spatholobi, 20 parts of Rhizoma Et Radix Notopterygii, frankincense
15 parts, 15 parts of myrrh, 25 parts of peach kernel, 25 parts of safflower, 25 parts of cassia twig, 25 parts of ramulus mori, 25 parts of the radix paeoniae rubrathe, 18 parts of Rhizoma Chuanxiong, 18 parts of Radix Angelicae Sinensis,
20 parts of earthworm, 30 parts of Rhizoma Gastrodiae, 35 parts of uncaria, 30 parts of selfheal, 18 30 parts of Fen, Common St.Paulswort Herbs of leech, 30 parts of Cortex Eucommiae, Ramulus Taxilli 25
Part.
In order to verify Liquid drug preparation of the present invention to hypertension, the therapeutic effect of cerebral infarction, applicant will use this hair
Bright Liquid drug preparation commission First Hospital traditional chinese medical science clinic of Yulin city carries out 200 hypertension, Cerebral Infarction Patients
Clinical observation experiment, test situation are as follows：
1st, clinical data
Experiment hypertension, cerebral infarction disease amount to 200 and select to outpatient, and the age is 41 years old minimum, 76 years old maximum, wherein 41-
55 years old 25,55-65 years old 135,65-76 years old 40, the course of disease is most 1 month short, longest 6 months.
2nd, diagnostic criteria
Nuclear-magnetism supplies to shake inspection result as cerebral infarction, clinical manifestation facial paralysis, hemiplegia, bicker
Salivation, extremity numbness, aphasia, headache, dizzy, blood pressure 140/100mmHg ~ 220/130mmHg, Hyperlipidemia.
3rd, criterion of therapeutical effect
Nuclear-magnetism checks no abnormality seen for shaking, and clinical manifestation symptom is all normal, subject to blood pressure, blood fat are normal, maintain 2-3 years with
On do not recur.
4th, therapy
Liquid drug preparation of the present invention is taken orally, 3 times a day, will be filled surely after half an hour after meal every time
The heating of 200ml medicine bags it is oral, seven dosage point are taken for seven days.
5th, criterion of therapeutical effect
Recovery from illness：Blood pressure, blood fat are normal, headache, dizzy disappearance, and freely, language expression is smooth for limb activity；It is effective：Clinical symptoms
And the sign person of having clear improvement；Effectively：Clinical symptoms and the sign person of making moderate progress；In vain：Clinical symptoms and sign are without improver.
6th, treatment results
In 200 hypertension, Cerebral Infarction Patients, recovery from illness 120 accounts for 60%, and effective 20 account for 10%, and effective 55 account for 27.5%,
Invalid 5 account for 2.5%, total effective rate 97.5%.
Model case
Mr. Liu, 55 years old, married, workers in enterprise, illness 7 years once happen suddenly brain according to my readme when on January 7th, 2010, evening slept
Block disease, household has found to be sent to the rescue of Yulin City First Hospital in time, be shown according to case history, blood pressure 220/130mmHg, the patient
Clinical manifestation goes out facial paralysis, speaks with a lisp, hemiplegia, the symptoms such as slobber, and fortunately rescue has held the state of an illness in time, by
After the treatment of 1 course for the treatment of of drug of the present invention, which improves, and measurement blood pressure is 140/100mmHg, treats 3 treatments
Cheng Hou, patient mental shine, and health does not recur so far.
In conclusion the present invention a kind of hypertension therapy, the cerebral infarction disease of logical stalkization bolt have special efficacy, patient's treatment
Blood pressure can restore normal as early as possible afterwards, and especially to suffering from cerebral infarction disease patient again without facial paralysis on ordinary days, numb limb, ability to speak is not
Clearly, hemiplegia is slobbered, and the premonitory symptoms such as dizziness occur, and physical condition restores normal.
The points for attention of the present invention：Suitable for qi deficiency to blood stasis endomorphy type patient, taking dose will consider weight factor, and brain goes out
Blood and body a part bleeder disabling, woman month menstrual period cut out.
Claims (4)
1. a kind of drug of logical stalkization bolt, which is characterized in that be made of the raw material of following weight：
15 ~ 50 parts of Radix Astragali, 10 ~ 40 parts of Radix Salviae Miltiorrhizae, 10 ~ 30 parts of hawthorn, 8 ~ 32 parts of gynostemma pentaphylla, 2 ~ 30 parts of radix cyathulae, Caulis Spatholobi 2 ~ 30
Part, 2 ~ 20 parts of Rhizoma Et Radix Notopterygii, 1 ~ 15 part of frankincense, 1 ~ 15 part of myrrh, 2 ~ 25 parts of peach kernel, 2 ~ 25 parts of safflower, 2 ~ 25 parts of cassia twig, ramulus mori 2 ~ 25
Part, 2 ~ 25 parts of the radix paeoniae rubrathe, 2 ~ 18 parts of Rhizoma Chuanxiong, 2 ~ 18 parts of Radix Angelicae Sinensis, 2 ~ 20 parts of earthworm, 2 ~ 30 parts of Rhizoma Gastrodiae, 5 ~ 35 parts of uncaria, selfheal 4 ~
30 parts, 2 ~ 18 2 ~ 30 parts of Fen, Common St.Paulswort Herbs of leech, 2 ~ 30 parts of Cortex Eucommiae, 2 ~ 25 parts of Ramulus Taxilli.
A kind of 2. drug of logical stalkization bolt according to claim 1, which is characterized in that the weight of wherein each raw material
It is：
25 ~ 40 parts of Radix Astragali, 15 ~ 35 parts of Radix Salviae Miltiorrhizae, 12 ~ 25 parts of hawthorn, 16 ~ 22 parts of gynostemma pentaphylla, 8 ~ 22 parts of radix cyathulae, Caulis Spatholobi 8 ~ 22
Part, 8 ~ 15 parts of Rhizoma Et Radix Notopterygii, 4 ~ 11 parts of frankincense, 4 ~ 11 parts of myrrh, 6 ~ 18 parts of peach kernel, 6 ~ 18 parts of safflower, 6 ~ 18 parts of cassia twig, ramulus mori 6 ~ 18
Part, 6 ~ 18 parts of the radix paeoniae rubrathe, 5 ~ 12 parts of Rhizoma Chuanxiong, 5 ~ 12 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of earthworm, 8 ~ 22 parts of Rhizoma Gastrodiae, 10 ~ 25 parts of uncaria, selfheal
10 ~ 22 parts, 5 ~ 12 8 ~ 22 parts of Fen, Common St.Paulswort Herbs of leech, 8 ~ 22 parts of Cortex Eucommiae, 6 ~ 18 parts of Ramulus Taxilli.
A kind of 3. drug of logical stalkization bolt according to claim 1, which is characterized in that the weight of wherein each raw material
It is：
35 parts of Radix Astragali, 25 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 18 parts of gynostemma pentaphylla, 10 parts of radix cyathulae, 10 parts of Caulis Spatholobi, 9 parts of Rhizoma Et Radix Notopterygii, frankincense 5
Part, 5 parts of myrrh, 8 parts of peach kernel, 8 parts of safflower, 8 parts of cassia twig, 8 parts of ramulus mori, 8 parts of the radix paeoniae rubrathe, 6 parts of Rhizoma Chuanxiong, 6 parts of Radix Angelicae Sinensis, earthworm 6 part, day
10 parts of fiber crops, 15 parts of uncaria, 12 parts of selfheal, 6 10 parts of Fen, Common St.Paulswort Herbs of leech, 10 parts of Cortex Eucommiae, 8 parts of Ramulus Taxilli.
4. the method prepared with claim 1, it is characterised in that：Take the medium-height grass of drug by weight ratio in inventive formulation
Seven dosage of medicine（The dose of seven days）, sealed after being packed into medicine bag, add in 5000-6000ml water and impregnate 1 hour, then soaked
The water and medicine bag of bubble are packed into automatic boiling-machine, and remove slag taking liquid after being decocted 45 minutes with mild and heavy respiration, is packed with machine, every bag
For 200ml, it is spare to be placed on refrigeration in refrigerator.
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| CN2016112586605 | 2016-12-30 | ||
| CN201611258660.5A CN106474356A (en) | 2016-12-30 | 2016-12-30 | A kind of medicine of logical stalkization bolt and preparation method thereof |
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| CN201711056389.1A Active CN108261505B (en) | 2016-12-30 | 2017-10-27 | Medicine for treating hypertension and cerebral infarction and preparation method thereof |
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| CN112891432A (en) * | 2021-04-09 | 2021-06-04 | 湖南三真康复医院股份有限公司 | A Chinese medicinal granule for treating apoplexy and preparation method thereof |
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| JP7158831B2 (en) * | 2017-06-30 | 2022-10-24 | 小林製薬株式会社 | Tablet containing goshitsu processed material |
| CN111759958B (en) * | 2020-07-15 | 2021-08-20 | 黑龙江中医药大学 | Medicine device is spouted in thrombus clearance |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520862A (en) * | 2003-01-29 | 2004-08-18 | 赵步长 | Prepared traditional Chinese medicine for apoplexy and obstruction of qi in the chest |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520862A (en) * | 2003-01-29 | 2004-08-18 | 赵步长 | Prepared traditional Chinese medicine for apoplexy and obstruction of qi in the chest |
Non-Patent Citations (1)
| Title |
|---|
| 潘金友等: "中西医结合治疗老年缺血性中风——附对脑血流影响的观察", 《辽宁中医杂志》 * |
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| CN112891432A (en) * | 2021-04-09 | 2021-06-04 | 湖南三真康复医院股份有限公司 | A Chinese medicinal granule for treating apoplexy and preparation method thereof |
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