CN112891432A - A Chinese medicinal granule for treating apoplexy and preparation method thereof - Google Patents
A Chinese medicinal granule for treating apoplexy and preparation method thereof Download PDFInfo
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- CN112891432A CN112891432A CN202110381656.2A CN202110381656A CN112891432A CN 112891432 A CN112891432 A CN 112891432A CN 202110381656 A CN202110381656 A CN 202110381656A CN 112891432 A CN112891432 A CN 112891432A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine granule for treating apoplexy and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations, wherein the traditional Chinese medicine granule comprises the following raw material components in parts by weight: 20-40 parts of astragalus; 5-10 parts of angelica; 4-8 parts of red peony root; heating semen Persicae 4-8 parts; 5-10 parts of safflower; 2-6 parts of salvia miltiorrhiza; 10-15 parts of caulis spatholobi; 2-6 parts of radix pseudostellariae; 3-8 parts of prepared rehmannia root; 3-8 parts of gentiana macrophylla; 3-8 parts of mulberry twigs. The preparation method comprises the following steps: s1, blending; s2, soaking; s3, extracting; s4, preparation of dry paste powder: concentrating under reduced pressure to obtain extract; drying the extract, and pulverizing to obtain dry extract powder; s5, granulating: adding dextrin and wetting agent, stirring, sieving, and making into wet granule; drying the wet granules and finishing the granules to obtain the finished product. The Chinese medicinal granules are used for treating the apoplexy caused by qi deficiency, blood stasis and obstruction of channels and collaterals, and are used for tonifying qi, nourishing blood, promoting blood circulation, removing blood stasis, dispelling wind and dredging collaterals.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine granule for treating apoplexy and a preparation method thereof.
Background
The stroke recovery period is a key period for the prognosis and the recovery of life ability of a patient and is also an important period for clinical treatment. However, modern western medicine lacks effective treatment means for treating stroke in the convalescent period, and is limited by problems such as infusion time window and the like, so that the clinical curative effect is poor. The traditional Chinese medicine emphasizes the combination of syndrome differentiation treatment, integral conditioning, staged treatment and syndrome differentiation treatment, and has unique treatment advantages.
In modern Chinese patent medicine preparations, many medicines for treating apoplexy are available, and the medicines are different in legislation and mainly comprise three types of blood-activating and stasis-resolving agents, qi-tonifying and blood-activating agents and blood-activating and phlegm-resolving wind-calming agents. The most commercially available blood-activating and stasis-resolving agents are Xinnaoshutong capsules, ginkgo leaf capsules, erigeron breviscapus granules, Tongmai granules, Xuesaitong, embolism-eliminating and collateral-dredging capsules, musk anti-embolism capsules, pseudo-ginseng Tongshu capsules and the like. The qi-tonifying and blood-activating agents are mostly thrombus heart-vessel-calming capsules, brain-benefiting tablets, heart-meridian-dredging capsules, thrombus-eliminating and dredging granules, brain-soothing granules, apoplexy-soothing oral liquid, brain-meridian-dredging capsules, brain-heart-dredging capsules and the like sold in the market. Blood circulation promoting, phlegm eliminating and wind calming agents are mostly brain meridian rehabilitation glue speak in a low voice, Naodesheng capsule, anti-thrombus re-made pill, brain benefiting and health restoring capsule, brain blood rehabilitation capsule, blood circulation promoting and muscle strengthening pill, Huatuo re-made pill, herba siegesbeckiae thrombus clearing pill, Tiandan collaterals dredging tablet and the like sold in the market.
The traditional Chinese medicine considers that the stroke is caused by disharmony of yin and yang of viscera, disorder of qi and blood and direct impact on the brain due to overstrain, internal injury, worry, anger, addiction to thick taste, smoking and wine and other inducements on the basis of deficiency of qi and blood, so that the stroke is caused by obstruction of the cerebral vessels or blood overflow of the cerebral vessels, and the pathogenesis of the stroke is not limited to six terminals of deficiency (yin deficiency, yang deficiency), fire (liver fire, heart fire), wind (liver wind, external wind), phlegm (wind phlegm and heat phlegm), qi (qi reversal, qi deficiency) and blood (blood stasis and blood heat). The disease condition is slow after the recovery period of the stroke, the deficient symptoms are obvious, the remaining pathogenic factors are incomplete, the marked-excess syndrome still exists, and qi deficiency and blood stasis collateral obstruction are the main pathogenesis of the recovery period of the stroke. Qi is the commander of blood, while vigorous qi makes blood flow, while unfavorable qi movement makes blood flow weak, and the blood cannot be normally pushed to flow, so that stagnation and stasis are caused, just as Wangqing ren Shen Yun: "original qi is deficient and must not reach blood vessel, blood is not gaseous, and blood must stay and get stasis". The generation of qi deficiency and blood stasis is mainly caused by qi deficiency, and the blood stasis can aggravate qi deficiency. The yang-tonifying and five-returning decoction is prepared from seven medicines of astragalus, angelica tail, red paeony root, earthworm, ligusticum wallichii, safflower and peach kernel, has the effects of tonifying qi, activating blood and dredging collaterals, is a classic and famous prescription for treating the syndrome of qi deficiency and blood stasis of stroke, is well-valued by doctors of all generations and is clinically used up to now.
In view of the above, the invention provides a novel traditional Chinese medicine granule for treating stroke and a preparation method thereof, wherein the traditional Chinese medicine granule is prepared by taking yang-tonifying five-returning decoction as a basic formula.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a traditional Chinese medicine granule for treating stroke and a preparation method thereof.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine granule for treating apoplexy comprises the following raw materials in parts by weight:
20-40 parts of astragalus; 5-10 parts of angelica; 4-8 parts of red peony root; heating semen Persicae 4-8 parts; 5-10 parts of safflower; 2-6 parts of salvia miltiorrhiza; 10-15 parts of caulis spatholobi; 2-6 parts of radix pseudostellariae; 3-8 parts of prepared rehmannia root; 3-8 parts of gentiana macrophylla; 3-8 parts of mulberry twigs.
More preferably: the composition comprises the following raw materials in parts by weight:
30 parts of astragalus; 8 parts of angelica; 6 parts of red peony root; semen Persicae is boiled in 6 parts; 7 parts of safflower; 4 parts of salvia miltiorrhiza; 12 parts of caulis spatholobi; 4 parts of radix pseudostellariae; 5 parts of prepared rehmannia root; 5 parts of gentiana macrophylla; 5 parts of mulberry twig.
A preparation method of traditional Chinese medicine granules for treating stroke comprises the following steps:
s1, preparing the ingredients
Weighing the raw materials according to the raw material components and the parts by weight of any one of the traditional Chinese medicine granules for treating apoplexy, and mixing to obtain a raw material mixture;
s2, soaking
Adding 6-10 times of water into the raw material mixture, and soaking for 40-80min to obtain a soaked mixture;
s3, extraction
Pouring the above soaking mixture into a decocting device, decocting at 80-90 deg.C for 1.5-2.5h, and filtering to obtain filter residue and primary filtrate; adding 6-10 times of water into the residue, decocting at 80-90 deg.C for 1-2 hr, and filtering to obtain residue and secondary filtrate; mixing the primary filtrate and the secondary filtrate, and uniformly mixing to obtain a liquid medicine;
s4 preparation of dry paste powder
Concentrating the medicinal liquid under reduced pressure to obtain extract with relative density of 1.28-1.36 at 60-70 deg.C; drying and crushing the extract to obtain dry extract powder;
s5, granulating
Adding dextrin and wetting agent into the dry extract powder according to the mass ratio of the dry extract powder to the dextrin being 1 (0.85-0.9) and the dry extract powder to the wetting agent being 1 (0.35-0.4), stirring uniformly, sieving and preparing wet granules; drying wet granules at 70-80 deg.C for 4-6 hr, oven drying, and grading to obtain Chinese medicinal granule.
More preferably: the wetting agent is ethanol.
More preferably: the dextrin is beta-cyclodextrin.
More preferably: the decocting device comprises a decocting pot, a filtrate mixing pot, a stirring mechanism, a central pipe, an electric heating coil and a discharging pipe;
a partition board used for dividing the frying pan into an upper cavity and a lower cavity is fixed in the frying pan, the electric heating coil is positioned in the lower cavity of the frying pan, the central pipe is inserted in the middle of the frying pan from bottom to top, the discharge pipe is positioned in the filtrate mixing pan and is connected with the central pipe through a pipeline, a control valve is installed on the pipeline, and a through hole is formed in the central pipe;
the filter liquor mixing pot is provided with a filter liquor outlet, and the stirring mechanism is arranged on the filter liquor mixing pot and is used for stirring materials between the central pipe and the filter liquor mixing pot.
More preferably: the filter is arranged in the central tube and detachably connected in the central tube.
More preferably: the filtering piece comprises a screen, a spring plate and a supporting block;
the screen cloth is used for being inserted into the bottom in the central pipe, so that the elastic pieces are contacted with the inner wall of the central pipe, and when the screen cloth is inserted in the central pipe, the supporting blocks are supported on the top surface of the central pipe.
More preferably: the stirring mechanism comprises a motor, a rotating shaft, a rotating disc, a stirring paddle and a fixing ring;
the frying and boiling pot is cylindrical, the top of the frying and boiling pot is arranged in an open mode, a flange arranged along the circumferential direction of the frying and boiling pot is fixed on the frying and boiling pot, a sliding groove is formed in the top of the flange, the rotating disc is located above the top of the frying and boiling pot and located in the middle of the fixing ring, a sliding strip matched with the sliding groove is fixed at the bottom of the fixing ring, and the sliding strip is inserted into the sliding groove and is in sliding fit with the sliding groove;
the axis of rotation lower extreme with the rolling disc center is fixed, the upper end with the motor output shaft is fixed, motor bolted connection be in on the boiling pan, the stirring rake includes first stirring rake and second stirring rake, first stirring rake with second stirring rake upper end is all fixed the rolling disc bottom, and the lower extreme all inserts the boiling pan with between the center tube, first stirring rake with distance between the rolling disc center with the second stirring rake with distance between the rolling disc center is different, traditional chinese medicine import and water inlet have been seted up on the rolling disc.
More preferably: the discharging pipe is a coiled pipe, and a plurality of liquid outlet holes are formed in the surface of the discharging pipe.
In conclusion, the invention has the following beneficial effects: according to the formula, the raw materials of the yang-tonifying and qi-restoring decoction are mainly prepared from astragalus, which can tonify primordial qi greatly, promote vigor when qi is strong, promote blood circulation to promote diuresis, remove blood stasis when blood circulation is performed, remove blood stasis without hurting vital qi, remove blood stasis and remove collaterals to cause impotence, and are used as main medicines. Removing rhizoma ligustici wallichii, adding salvia miltiorrhiza and caulis spatholobi, nourishing blood and activating blood, removing blood stasis and dredging collaterals, and combining with angelica, red paeony root, blanched semen persicae and safflower, has the functions of activating blood and removing blood stasis, and clearing and activating the channels and collaterals, so as to assist the functions of main drugs. Radix Pseudostellariae is added to supplement qi and nourish yin, and is combined with radix astragali to enhance qi-invigorating and fluid-producing effects; the addition of prepared rehmannia root has the effects of nourishing yin and blood, replenishing vital essence and replenishing marrow, and is suitable for various blood deficiency syndromes. Removing lumbricus, adding Qin jiao, dispelling wind, dredging collaterals and relieving spasm, adding sang Zhi, dispelling wind, dredging collaterals and benefiting joints, and is suitable for the syndrome of spasm of limbs due to apoplexy. The whole formula is used for tonifying and dredging, the astragalus, the angelica, the radix pseudostellariae and the prepared rehmannia root can tonify qi and blood, the angelica, the red paeony root, the blanched peach seed, the safflower, the salvia miltiorrhiza and the suberect spatholobus stem can activate blood circulation, remove stasis and dredge channels, the gentiana macrophylla and the mulberry twig can dispel wind, dredge collaterals and relieve spasm, and the effects of tonifying qi, nourishing blood, activating blood circulation, removing stasis, dispelling wind and dredging collaterals are achieved by combining the medicines. The traditional Chinese medicine can be used for treating the root cause of diseases by promoting the circulation of qi and blood, treating the secondary cause of diseases by removing blood stasis and dredging collaterals, and promoting blood circulation of the whole body, so that the traditional Chinese medicine can treat both symptoms and root causes, can tonify qi without congestion, and can promote blood circulation without hurting the body resistance, and all symptoms are cured.
Drawings
FIG. 1 is a block flow diagram of an embodiment, which is mainly used for embodying a method for preparing Chinese medicinal granules;
FIG. 2 is a schematic structural diagram of an embodiment, which is mainly used for embodying the structure of a decocting device;
FIG. 3 is a schematic cross-sectional view of an embodiment, primarily for embodying the filter construction;
fig. 4 is a schematic bottom view of the stirring mechanism according to the embodiment, which is mainly used for showing the structure of the stirring mechanism.
In the figure, 1, a frying pan; 2. a filtrate mixing pot; 3. a residue outlet; 4. a liquid medicine outlet; 51. a motor; 52. a rotating shaft; 53. rotating the disc; 541. a first stirring paddle; 542. a second stirring paddle; 55. a fixing ring; 56. a slide bar; 57. importing traditional Chinese medicines; 58. a water inlet; 6. a flange; 7. a filter member; 71. screening a screen; 72. a spring plate; 73. a support block; 8. a central tube; 9. a partition plate; 10. an electric heating coil pipe; 11. a control valve; 12. a discharge pipe; 13. a through hole; 14. and a liquid outlet hole.
Detailed Description
The invention is described in detail below with reference to the figures and examples.
Example 1: a traditional Chinese medicine granule for treating apoplexy and a preparation method thereof, the traditional Chinese medicine granule comprises the following raw material components by weight:
30g of astragalus; 8g of Chinese angelica; 6g of red paeony root; blanched peach kernel 6 g; 7g of safflower; 4g of salvia miltiorrhiza; 12g of caulis spatholobi; 4g of radix pseudostellariae; 5g of prepared rehmannia root; 5g of gentiana macrophylla; 5g of mulberry twig.
In the technical scheme, in recent years, the yang-tonifying and five-returning decoction has been widely clinically researched for treating apoplexy, and the yang-tonifying and five-returning decoction is mainly used as a basic formula and is subjected to reduction treatment, so that the clinical curative effect is obvious. Modern pharmacological research shows that the yang-tonifying five-returning decoction has the following characteristics: directly inhibit the generation of brain peroxide and reduce the damage of oxygen free radicals to blood brain barrier and brain cells; improving microcirculation, improving hypoxia tolerance of tissues, improving platelet function, improving fibrinolysis capacity and improving blood circulation state; the test of a mouse cerebral embolism model proves that the composition can reduce the content of cholesterol in the artery wall; inhibiting blood coagulation, resisting thrombosis, preventing thrombus recurrence, inhibiting and dissolving thrombus, and promoting collateral circulation; regulating blood flow distribution, promoting tissue regeneration and repair, etc. Therefore, aiming at the common apoplexy caused by qi deficiency and blood stasis in clinic, the invention takes yang-tonifying five-returning decoction as a basic formula, and adds reduction and sanction according to the evidence to summarize and form the prescription of the particles (traditional Chinese medicine particles) for strengthening and relieving paralysis.
According to the original formula, the astragalus is mainly used as a main drug, and has the effects of tonifying primordial qi, promoting vigor by vigorous qi, promoting blood circulation to remove blood stasis, removing blood stasis without damaging vital qi, removing blood stasis and dredging collaterals, and causing impotence. Removing rhizoma ligustici wallichii, adding salvia miltiorrhiza and caulis spatholobi, nourishing blood and activating blood, removing blood stasis and dredging collaterals, and combining with angelica, red paeony root, blanched semen persicae and safflower, has the functions of activating blood and removing blood stasis, and clearing and activating the channels and collaterals, so as to assist the functions of main drugs. Radix Pseudostellariae is added to supplement qi and nourish yin, and is combined with radix astragali to enhance qi-invigorating and fluid-producing effects; the addition of prepared rehmannia root has the effects of nourishing yin and blood, replenishing vital essence and replenishing marrow, and is suitable for various blood deficiency syndromes. Removing lumbricus, adding Qin jiao, dispelling wind, dredging collaterals and relieving spasm, adding sang Zhi, dispelling wind, dredging collaterals and benefiting joints, and is suitable for the syndrome of spasm of limbs due to apoplexy. The whole formula is used for tonifying and dredging, the astragalus, the angelica, the radix pseudostellariae and the prepared rehmannia root can tonify qi and blood, the angelica, the red paeony root, the blanched peach seed, the safflower, the salvia miltiorrhiza and the suberect spatholobus stem can activate blood circulation, remove stasis and dredge channels, the gentiana macrophylla and the mulberry twig can dispel wind, dredge collaterals and relieve spasm, and the effects of tonifying qi, nourishing blood, activating blood circulation, removing stasis, dispelling wind and dredging collaterals are achieved by combining the medicines. The traditional Chinese medicine can be used for treating the root cause of diseases by promoting the circulation of qi and blood, treating the secondary cause of diseases by removing blood stasis and dredging collaterals, and promoting blood circulation of the whole body, so that the traditional Chinese medicine can treat both symptoms and root causes, can tonify qi without congestion, and can promote blood circulation without hurting the body resistance, and all symptoms are cured.
The formula is a fixed proved formula which is prepared from eleven traditional Chinese medicines, namely, astragalus, angelica, red paeony root, blanched peach seed, safflower, salvia miltiorrhiza, suberect spatholobus stem, heterophylly falsestarwort root, prepared rehmannia root, largeleaf gentian root and mulberry twig, is developed through compatibility according to clinical requirements and experiences, and has the functions of tonifying qi and nourishing blood, promoting blood circulation by removing blood stasis, dispelling wind and dredging collaterals. Can be used for treating apoplexy due to qi deficiency, blood stasis, and obstruction of collaterals, with symptoms of headache, giddiness, short breath, debilitation, hemiplegia, facial distortion, dysphasia, numbness or weakness of limbs; cerebral thrombosis, cerebral arteriosclerosis, and apoplexy with the above syndromes in convalescent period. Through clinical application, the formula has definite curative effect and no toxic or side effect.
The preparation method of the traditional Chinese medicine granules is shown in figures 1-4 and comprises the following steps:
s1, preparing the ingredients
Weighing the raw materials according to the raw material components and the parts by weight of the traditional Chinese medicine granules for treating the apoplexy, and mixing to obtain a raw material mixture;
s2, soaking
Adding water 8 times the weight of the raw material mixture into the raw material mixture, and soaking for 60min to obtain a soaked mixture;
s3, extraction
Pouring the soaked mixture into a decocting device, decocting at 85 deg.C for 2 hr, and filtering to obtain filter residue and primary filtrate; adding 8 times of water into the residue, decocting at 85 deg.C for 1.5 hr, and filtering to obtain residue and secondary filtrate; mixing the primary filtrate and the secondary filtrate, and uniformly mixing to obtain a liquid medicine;
s4 preparation of dry paste powder
Concentrating the medicinal liquid under reduced pressure to obtain extract with relative density of 1.31 at 65 deg.C; spray drying the extract, and pulverizing to obtain dry extract powder;
s5, granulating
Adding dextrin and wetting agent into the dry extract powder according to the mass ratio of the dry extract powder to the dextrin of 1:0.88 and the dry extract powder to the wetting agent of 1:0.38, stirring uniformly, and sieving with a 20-mesh sieve to prepare wet granules; drying the wet granules at 75 deg.C for 5 hr, oven drying, grading to obtain traditional Chinese medicine granules, and packaging to obtain final product.
In the technical scheme, the dextrin is an auxiliary material, preferably, the dextrin is beta-cyclodextrin, and the wetting agent is ethanol.
In the technical scheme, the preparation process of the traditional Chinese medicine granules adopts two extraction modes, so that the effective ingredients in the raw material components are fully extracted, the medicinal value of the raw material components is improved, and the cost is saved. The preparation method has simple process, and the prepared traditional Chinese medicine granules (Fuji Zhensliao granules) are used for treating the apoplexy caused by qi deficiency, blood stasis and obstruction of channels and collaterals, and are used for tonifying qi, nourishing blood, promoting blood circulation, removing blood stasis, dispelling wind and dredging collaterals.
Referring to fig. 1-4, the decocting apparatus includes a decocting pan 1, a filtrate mixing pan 2, a stirring mechanism, a central tube 8, an electric heating coil 10, and a discharge tube 12. A clapboard 9 used for dividing the frying pan 1 into an upper chamber and a lower chamber is fixed in the frying pan 1, and an electric heating coil 10 is positioned in the lower chamber of the frying pan 1. The central tube 8 is inserted into the middle of the frying and boiling pan 1 from bottom to top, the frying and boiling pan 1 is cylindrical, and the central axis of the central tube 8 is on the same straight line with the central axis of the central tube. The upper end of the central tube 8 is positioned in the central tube 8, the lower end of the central tube passes through the bottom of the frying pan 1, and the electric heating coil 10 is positioned below the partition board 9 and is coiled around the central tube 8. In order to convey the filtrate through the central tube 8, preferably, a plurality of through holes 13 are formed in the circumferential surface of the central tube 8, and the through holes 13 are all located in the upper chamber of the decocting pot 1 and are uniformly distributed on the surface of the central tube 8.
Referring to fig. 1 to 4, the discharge pipe 12 is located in the filtrate mixing pot 2 and is connected to the central pipe 8 through a pipeline, a control valve 11 is installed on the pipeline, the control valve 11 may be an electromagnetic valve or a manual switch valve, and the specific type is not limited herein. The frying and boiling pot 1 is provided with a residue outlet 3, and the residue outlet 3 is positioned at one side below the upper cavity of the frying and boiling pot 1. The filtrate mixing pot 2 is provided with a liquid outlet 14, and the liquid outlet 14 is positioned at one side below the filtrate mixing pot 2. A plurality of liquid outlet holes 14 are formed in the circumferential surface of the discharge pipe 12, and the liquid outlet holes 14 are all located in the filtrate mixing pot 2 and are uniformly distributed on the discharge pipe 12. The discharge pipe 12 is a coiled pipe, one end of the discharge pipe is connected with the central pipe 8 through a pipeline, the other end of the discharge pipe is a closed end, and the end face of the discharge pipe is also provided with a liquid outlet 14.
In the technical scheme, because the traditional Chinese medicine particles are required to be extracted secondarily in the preparation process, if the traditional decocting equipment is adopted for decocting, a plurality of steps are required to be operated repeatedly, and inconvenience and troublesome and complicated operation are brought in the process of combining primary filtrate and secondary filtrate, so that the operation steps of the extraction process are reduced, and the work efficiency is accelerated. The decocting device mainly comprises two independent pot bodies, namely a decocting pot 1 and a filtrate mixing pot 2, wherein the decocting pot 1 is used for decocting, the filtrate mixing pot 2 is used for mixing primary filtrate and secondary filtrate, and the use is simple and convenient.
Because the central tube 8 is connected with the discharge tube 12 through a pipeline, and the discharge tube 12 is arranged in the filtrate mixing pot 2 in a snake shape, after primary decoction is completed, primary filtrate enters the filtrate mixing pot 2 through the central tube 8 and the discharge tube 12 for storage, and after secondary decoction is completed, secondary filtrate enters the discharge tube 12 through the central tube 8 and finally enters the filtrate mixing pot 2 through the liquid outlet hole 14 on the discharge tube 12, so that the primary filtrate in the filtrate mixing pot 2 is uniformly mixed. The discharge pipe 12 is snakelike to be arranged, can make secondary filtrate can mix fast and even mixture with primary filtrate in filtrating hybrid kettle 2, need not set up agitating unit in addition and stir primary filtrate and secondary filtrate.
Referring to fig. 1 to 4, in order to make the primary filtrate and the secondary filtrate entering the filtrate mixing pot 2 as free as possible of suspended particles, it is preferable that a filter member 7 for intercepting solid impurities is provided in the central tube 8, and the filter member 7 is detachably attached to the central tube 8. Specifically, the filter 7 includes a screen 71, a spring 72, and a support block 73. The two elastic pieces 72 are respectively fixed on two opposite sides of the screen 71, the lower end of each elastic piece 72 is fixed with the screen 71, and the upper end of each elastic piece 72 inclines towards the outer side of the screen 71 and is fixed with the supporting block 73. The screen 71 is inserted into the bottom of the center tube 8, so that the elastic sheet 72 contacts with the inner wall of the center tube 8, when the screen 71 is inserted into the center tube 8, the supporting block 73 is supported on the top surface of the center tube 8, the elastic sheet 72 abuts against the inner wall of the center tube 8, and the screen 71 is located below the lowest through hole 13. The screen 71 is circular in plan view, has the same diameter as the inner diameter of the central tube 8, and the screen 71 is hollow and semi-elliptical and has an outer arc surface facing downward.
In above-mentioned technical scheme, through-hole 13's setting, aim at makes the inside and outside intercommunication of center tube 8 to make things convenient for raw materials component to fully decoct, consequently through-hole 13 aperture should not set up the undersize, otherwise through-hole 13 blocks up easily, thereby influences the decocte, and through-hole 13 blocks up the clearance and is more troublesome. Therefore, the detachable filter element 7 is inserted in the central tube 8, when primary filtrate and secondary filtrate are discharged, large-particle impurities are intercepted through the through hole 13, and then small-particle impurities are intercepted through the screen 71, so that the primary filtrate and the secondary filtrate entering the filtrate mixing pot 2 do not contain suspended particles as much as possible, and the filtering effect is good. The arrangement of the elastic sheet 72 enables the elastic sheet 72 to abut against the inner wall of the central tube 8 when the screen 71 is inserted into the central tube 8, so that the screen 71 is prevented from moving in the central tube 8 under the action of buoyancy, and the installation stability of the screen 71 is improved.
Referring to fig. 1-4, a stirring mechanism is mounted on the fryer 1 and is used to stir the material between the central tube 8 and the fryer 1. Preferably, the stirring mechanism includes a motor 51, a rotating shaft 52, a rotating disk 53, a stirring paddle, and a fixing ring 55. The top of the frying and boiling pot 1 is open, and a flange 6 arranged along the circumferential direction of the frying and boiling pot 1 is fixed on the outer surface of the top of the frying and boiling pot 1. The top of the flange 6 is provided with a chute which is circular and is arranged around the frying and boiling pot 1. The turning disc 53 is located above the top of the fryer 1 and in the middle of the fixing ring 55, which fixing ring 55 is supported above the flange 6. A circle of slide bars 56 matched with the sliding grooves are fixed at the bottom of the fixing ring 55, and the slide bars 56 are inserted into the sliding grooves and are in sliding fit with the sliding grooves. The lower end of the rotating shaft is fixed with the center of the rotating disc 53, the upper end of the rotating shaft is fixed with an output shaft of the motor 51, and the motor 51 is positioned above the rotating disc 53 and is connected to the shell of the frying and boiling pan 1 through bolts. The central axis of the central tube 8 and the central axis of the rotating disc 53 are positioned on the same vertical line. The stirring paddles comprise a first stirring paddle 541 and a second stirring paddle 542, the upper ends of the first stirring paddle 541 and the second stirring paddle 542 are fixed at the bottom of the rotating disc 53, and the lower ends of the first stirring paddle 541 and the second stirring paddle 542 are inserted between the decocting pot 1 and the central tube 8. The first stirring paddle 541 and the second stirring paddle 542 are both inclined blade type blades, and the first stirring paddle 541 and the second stirring paddle 542 are respectively located at two opposite sides of the center of the rotating disc 53. The distance between the first paddles 541 and the center of the rotating disk 53 is greater than the distance between the second paddles 542 and the center of the rotating disk 53, so that the first paddles 541 and the second paddles 542 can stir the material at different positions. The rotating disc 53 is provided with a traditional Chinese medicine inlet 57 and a water inlet 58, and the traditional Chinese medicine inlet 57 and the water inlet 58 are respectively positioned at two opposite sides of the rotating shaft.
In the above technical scheme, in the decocting process, the motor 51 can be started to enable the rotating disc 53 and the fixing ring 55 to rotate above the decocting pan 1, and since the first stirring paddle 541 and the second stirring paddle 542 are both fixed on the rotating disc 53 and both located between the central tube 8 and the inner wall of the decocting pan 1, when the rotating disc 53 rotates, the first stirring paddle 541 and the second stirring paddle 542 will rotate around the center of the rotating disc 53 between the central tube 8 and the inner wall of the decocting pan 1, so that the materials in the decocting pan 1 can be stirred, and the decocting efficiency is accelerated.
Example 2: the difference between the traditional Chinese medicine granules for treating stroke and the preparation method thereof in the embodiment 1 is that the traditional Chinese medicine granules comprise the following raw material components in parts by weight:
20g of astragalus; 5g of Chinese angelica; 4g of red paeony root; heating semen Persicae in water for 4 g; 5g of safflower; 2g of salvia miltiorrhiza; 10g of caulis spatholobi; 2g of radix pseudostellariae; 3g of prepared rehmannia root; 3g of gentiana macrophylla; 3g of mulberry twig.
The preparation method of the traditional Chinese medicine granules comprises the following steps:
s1, preparing the ingredients
Weighing the raw materials according to the raw material components and the parts by weight of the traditional Chinese medicine granules for treating the apoplexy, and mixing to obtain a raw material mixture;
s2, soaking
Adding 6 times of water into the raw material mixture, and soaking for 40min to obtain a soaked mixture;
s3, extraction
Pouring the soaked mixture into a decocting device, decocting at 80 deg.C for 1.5h, and filtering to obtain filter residue and primary filtrate; adding 8 times of water into the residue, decocting at 80 deg.C for 1 hr, and filtering to obtain residue and secondary filtrate; mixing the primary filtrate and the secondary filtrate, and uniformly mixing to obtain a liquid medicine;
s4 preparation of dry paste powder
Concentrating the medicinal liquid under reduced pressure to obtain extract with relative density of 1.28 at 60 deg.C; spray drying the extract, and pulverizing to obtain dry extract powder;
s5, granulating
Adding dextrin and wetting agent into the dry paste powder according to the mass ratio of the dry paste powder to the dextrin of 1:0.85 and the dry paste powder to the wetting agent of 1:0.35, uniformly stirring, and sieving by a 20-mesh sieve to prepare wet granules; drying the wet granules at 70 deg.C for 4 hr, oven drying, grading to obtain traditional Chinese medicine granules, and packaging to obtain final product.
Example 3: the difference between the traditional Chinese medicine granules for treating stroke and the preparation method thereof in the embodiment 1 is that the traditional Chinese medicine granules comprise the following raw material components in parts by weight:
40g of astragalus; 10g of Chinese angelica; 8g of red paeony root; scalding semen Persicae in 8 g; 10g of safflower; 6g of salvia miltiorrhiza; 15g of caulis spatholobi; 6g of radix pseudostellariae; 8g of prepared rehmannia root; 8g of gentiana macrophylla; 8g of mulberry twig.
The preparation method of the traditional Chinese medicine granules comprises the following steps:
s1, preparing the ingredients
Weighing the raw materials according to the raw material components and the parts by weight of the traditional Chinese medicine granules for treating the apoplexy, and mixing to obtain a raw material mixture;
s2, soaking
Adding water 8 times the weight of the raw material mixture into the raw material mixture, and soaking for 80min to obtain a soaked mixture;
s3, extraction
Pouring the soaked mixture into a decocting device, decocting at 90 deg.C for 2.5h, and filtering to obtain filter residue and primary filtrate; adding 8 times of water into the residue, decocting at 90 deg.C for 2 hr, and filtering to obtain residue and secondary filtrate; mixing the primary filtrate and the secondary filtrate, and uniformly mixing to obtain a liquid medicine;
s4 preparation of dry paste powder
Concentrating the medicinal liquid under reduced pressure to obtain extract with relative density of 1.36 at 70 deg.C; spray drying the extract, and pulverizing to obtain dry extract powder;
s5, granulating
Adding dextrin and wetting agent into the dry paste powder according to the mass ratio of the dry paste powder to the dextrin of 1:0.9 and the dry paste powder to the wetting agent of 1:0.4, uniformly stirring, and sieving by a 20-mesh sieve to prepare wet granules; drying the wet granules at 80 deg.C for 6 hr, oven drying, grading to obtain traditional Chinese medicine granules, and packaging to obtain final product.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that several improvements and modifications without departing from the principle of the present invention will occur to those skilled in the art, and such improvements and modifications should also be construed as within the scope of the present invention.
Claims (10)
1. A traditional Chinese medicine granule for treating stroke is characterized in that: the composition comprises the following raw materials in parts by weight:
20-40 parts of astragalus; 5-10 parts of angelica; 4-8 parts of red peony root; heating semen Persicae 4-8 parts; 5-10 parts of safflower; 2-6 parts of salvia miltiorrhiza; 10-15 parts of caulis spatholobi; 2-6 parts of radix pseudostellariae; 3-8 parts of prepared rehmannia root; 3-8 parts of gentiana macrophylla; 3-8 parts of mulberry twigs.
2. The traditional Chinese medicine granule for treating stroke according to claim 1, characterized in that: the composition comprises the following raw materials in parts by weight:
30 parts of astragalus; 8 parts of angelica; 6 parts of red peony root; semen Persicae is boiled in 6 parts; 7 parts of safflower; 4 parts of salvia miltiorrhiza; 12 parts of caulis spatholobi; 4 parts of radix pseudostellariae; 5 parts of prepared rehmannia root; 5 parts of gentiana macrophylla; 5 parts of mulberry twig.
3. A preparation method of traditional Chinese medicine granules for treating stroke is characterized by comprising the following steps: the method comprises the following steps:
s1, preparing the ingredients
Weighing the raw material components and the parts by weight of the traditional Chinese medicine granules for treating stroke according to any one of claims 1-2, and mixing to obtain a raw material mixture;
s2, soaking
Adding 6-10 times of water into the raw material mixture, and soaking for 40-80min to obtain a soaked mixture;
s3, extraction
Pouring the above soaking mixture into a decocting device, decocting at 80-90 deg.C for 1.5-2.5h, and filtering to obtain filter residue and primary filtrate; adding 6-10 times of water into the residue, decocting at 80-90 deg.C for 1-2 hr, and filtering to obtain residue and secondary filtrate; mixing the primary filtrate and the secondary filtrate, and uniformly mixing to obtain a liquid medicine;
s4 preparation of dry paste powder
Concentrating the medicinal liquid under reduced pressure to obtain extract with relative density of 1.28-1.36 at 60-70 deg.C; drying and crushing the extract to obtain dry extract powder;
s5, granulating
Adding dextrin and wetting agent into the dry extract powder according to the mass ratio of the dry extract powder to the dextrin being 1 (0.85-0.9) and the dry extract powder to the wetting agent being 1 (0.35-0.4), stirring uniformly, sieving and preparing wet granules; drying wet granules at 70-80 deg.C for 4-6 hr, oven drying, and grading to obtain Chinese medicinal granule.
4. The method for preparing a Chinese medicinal granule for treating stroke according to claim 3, wherein the Chinese medicinal granule comprises the following raw materials: the wetting agent is ethanol.
5. The method for preparing a Chinese medicinal granule for treating stroke according to claim 3, wherein the Chinese medicinal granule comprises the following raw materials: the dextrin is beta-cyclodextrin.
6. The method for preparing a Chinese medicinal granule for treating stroke according to claim 3, wherein the Chinese medicinal granule comprises the following raw materials: the decocting device comprises a decocting pot (1), a filtrate mixing pot (2), a stirring mechanism, a central pipe (8), an electric heating coil pipe (10) and a discharge pipe (12);
a partition plate (9) used for dividing the frying and boiling pot (1) into an upper cavity and a lower cavity is fixed in the frying and boiling pot (1), the electric heating coil (10) is located in the lower cavity of the frying and boiling pot (1), the central pipe (8) is inserted into the middle of the frying and boiling pot (1) from bottom to top, the discharge pipe (12) is located in the filtrate mixing pot (2) and is connected with the central pipe (8) through a pipeline, a control valve (11) is installed on the pipeline, and a through hole (13) is formed in the central pipe (8);
the filter residue mixing device is characterized in that a residue outlet (3) is formed in the decocting pot (1), a liquid outlet hole (14) is formed in the filter liquid mixing pot (2), and the stirring mechanism is installed on the decocting pot (1) and used for stirring materials between the central pipe (8) and the decocting pot (1).
7. The method for preparing a Chinese medicinal granule for treating stroke according to claim 6, wherein the Chinese medicinal granule comprises the following raw materials: be provided with in center tube (8) and filter piece (7), it connects to filter piece (7) can dismantle in center tube (8).
8. The method for preparing a Chinese medicinal granule for treating stroke according to claim 7, wherein the Chinese medicinal granule comprises the following raw materials: the filter element (7) comprises a screen (71), an elastic sheet (72) and a supporting block (73);
the elastic pieces (72) are arranged in two numbers, the two elastic pieces (72) are fixed on two opposite sides of the screen (71) respectively, the lower ends of the elastic pieces (72) are fixed to the screen (71), the upper ends of the elastic pieces incline towards the outer side of the screen (71) and are fixed to the supporting blocks (73), the screen (71) is used for being inserted into the inner bottom of the central tube (8) so that the elastic pieces (72) are in contact with the inner wall of the central tube (8), and when the screen (71) is inserted into the central tube (8), the supporting blocks (73) are supported on the top surface of the central tube (8).
9. The method for preparing a Chinese medicinal granule for treating stroke according to claim 8, wherein the Chinese medicinal granule comprises: the stirring mechanism comprises a motor (51), a rotating shaft (52), a rotating disc (53), a stirring paddle and a fixing ring (55);
the frying and boiling pot (1) is cylindrical, the top of the frying and boiling pot is arranged in an open mode, a flange (6) arranged along the circumferential direction of the frying and boiling pot (1) is fixed on the frying and boiling pot (1), a sliding groove is formed in the top of the flange (6), the rotating disc (53) is located above the top of the frying and boiling pot (1) and located in the middle of the fixing ring (55), a sliding strip (56) matched with the sliding groove is fixed at the bottom of the fixing ring (55), and the sliding strip (56) is inserted into the sliding groove and is in sliding fit with the sliding groove;
the axis of rotation lower extreme with rolling disc (53) center is fixed, the upper end with motor (51) output shaft is fixed, motor (51) bolted connection be in on boiling pan (1), the stirring rake includes first stirring rake (541) and second stirring rake (542), first stirring rake (541) with second stirring rake (542) upper end is all fixed rolling disc (53) bottom, and the lower extreme all inserts boiling pan (1) with between center tube (8), first stirring rake (541) with distance between rolling disc (53) center with second stirring rake (542) with distance between rolling disc (53) center is different, traditional chinese medicine import (57) and water inlet (58) have been seted up on rolling disc (53).
10. The method for preparing a Chinese medicinal granule for treating stroke according to claim 8, wherein the Chinese medicinal granule comprises: the discharge pipe (12) is a coiled pipe, and the surface of the discharge pipe is provided with a plurality of liquid outlet holes (14).
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Application publication date: 20210604 |