CN101658656B - Medicine for curing cholelithiasis - Google Patents

Abstract

A medicine for curing cholelithiasis adopts more than ten natural Chinese herbal medicines such as loosestrife, absinthin, gardenia, saltpeter, mirabilite, bitter orange, curcuma longa, magnolia officinalis, rhizoma corydalis, scutellaria, bupleurum, dried alum, pinellia ternate, white peony root, galli stomachichum corium, honeysuckle, dandelion, chinaberry fruit, pangolin and the like. The medicines are compounded scientifically and reasonably so that the efficacy of each medicine generates a cooperative function, the compounding way is unique and the compounding is strict. The four following steps, such as dissolving, moving, washing and discharging, can be summarized for curing cholelithiasis, and the medicine overcomes the defects that the existing medicine for curing cholelithiasis has long medicine-taking time, slow stone elimination speed, low effective rate and recrudescence after treatment. The medicine takes 20 days as one treatment course and the patient with the disease of cholelithiasis can be generally cured after 1-2 treatment courses. The effective rate achieves more than 98% and the curative rate achieves more than 94%. The medicine has the advantages of quick effect, short period of treatment, high curative rate, no toxicity, safety, reliability and the like; furthermore, the raw material has rich source, the fabrication method is simple, the cost is low and the medicine is the preferably selected medicine for the wide patients with the disease of cholelithiasis.

Description

The medicine of treatment cholelithiasis

Technical field

The present invention relates to a kind of medicine for the treatment of cholelithiasis, belong to the field of Chinese medicines.

Background technology

Cholelithiasis is a kind of commonly encountered diseases of serious harm human health, can betide gallbladder, stones in intrahepatic bile duct and common bile duct, and its prevalence is different because of factors such as race, heredity, geography, diet.Along with the progressively raising of China's living standards of the people, dietary structure changes, and the sickness rate of cholelithiasis rises rapidly.

Cholecystitis is clinical comparatively common, and 11.6% is acute cholecystitis among the cholecystitis patient, and chronic cholecystitis is the chronic inflammation pathological changes of gallbladder, and sickness rate mostly is chronic calculous cholecystitis greatly about 10%.Present western medical treatment cholelithiasis is based on operation, but effect is unsatisfactory, and the postoperative remnant gallstone rate is up to 30-40%, relapse rate height.

Use the treatment by Chinese herbs cholelithiasis, have no contraindication, safety, effective, side effect is little, easily by plurality of advantages such as the patient accept.But, existing medicine for the treatment of cholelithiasis, cholecystitis and biliary tract inflammation etc., it is long to exist medicine time in various degree, and calculus is slower, and is most after 2 weeks of back of taking medicine, discrete even period of greater than two months, effective percentage is low, and healing back appearance " bounce-back " etc. are not enough.

Summary of the invention

The objective of the invention is at above-mentioned deficiency, excavate and utilize effective prescription in the pools of traditional Chinese medicine, the medicine of a kind of prescription uniqueness, cost treatment cholelithiasis low, safe and reliable, evident in efficacy is provided.

The cholelithiasis that the present invention is alleged comprises cholelithiasis, liver and bile stone, cholecystitis, biliary tract inflammation and biliary postoperative syndrome etc.

Drug main of the present invention will be selected Herba Lysimachiae, Herba Artemisiae Scopariae, Fructus Gardeniae for use, forge ten multi-flavor natural Chinese medicinal herb such as Sal Nitri, Natrii Sulfas, Fructus Aurantii, Radix Curcumae, Cortex Magnoliae Officinalis, Rhizoma Corydalis, Radix Scutellariae, Radix Bupleuri, dried Alumen, the Rhizoma Pinelliae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, Flos Lonicerae, Herba Taraxaci, Fructus Toosendan, Squama Manis, through scientific and reasonable compatibility, make the effect of each medicine produce synergism, thereby reach the purpose of effective treatment cholelithiasis.

The objective of the invention is to be achieved through the following technical solutions.

The medicine of this treatment cholelithiasis, make by following raw medicaments in portion by weight:

Herba Lysimachiae 15-35 part, Herba Artemisiae Scopariae 15-35 part, Fructus Gardeniae 9-21 part, forge Sal Nitri 9-21 part, Natrii Sulfas 12-28 part, Fructus Aurantii 9-21 part, Radix Curcumae 12-28 part, Cortex Magnoliae Officinalis 6-14 part, Rhizoma Corydalis 12-28 part, Radix Scutellariae 6-14 part, Radix Bupleuri 9-21 part, dried Alumen 6-14 part, Rhizoma Pinelliae 6-14 part, Radix Paeoniae Alba 9-21 part, Endothelium Corneum Gigeriae Galli 15-35 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, Fructus Toosendan 12-28 part, Squama Manis 9-21 part.

Each amounts of components all has better curative effect in the following weight parts scope:

Herba Lysimachiae 20-30 part, Herba Artemisiae Scopariae 20-30 part, Fructus Gardeniae 12-18 part, forge Sal Nitri 12-18 part, Natrii Sulfas 16-24 part, Fructus Aurantii 12-18 part, Radix Curcumae 16-24 part, Cortex Magnoliae Officinalis 8-12 part, Rhizoma Corydalis 16-24 part, Radix Scutellariae 8-12 part, Radix Bupleuri 12-18 part, dried Alumen 8-12 part, Rhizoma Pinelliae 8-12 part, Radix Paeoniae Alba 12-18 part, Endothelium Corneum Gigeriae Galli 20-30 part, Flos Lonicerae 20-30 part, Herba Taraxaci 20-30 part, Fructus Toosendan 16-24 part, Squama Manis 12-18 part.

Be preferably:

25 parts of Herba Lysimachiaes, 25 parts of Herba Artemisiae Scopariaes, 15 parts of Fructus Gardeniaes, forge 15 parts on Sal Nitri, 20 parts in Natrii Sulfas, 15 parts of Fructus Aurantiis, 20 parts of Radix Curcumaes, 10 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Corydalis, 10 parts of Radix Scutellariaes, 15 parts of Radix Bupleuri, 10 parts of dried Alumens, 10 parts of the Rhizoma Pinelliaes, 15 parts of the Radix Paeoniae Albas, 25 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Flos Loniceraes, 25 parts of Herba Taraxacis, 20 parts of Fructus Toosendans, 15 parts of Squama Maniss.

In order better to bring into play the therapeutical effect of crude drug, the Fructus Aurantii among the present invention, Endothelium Corneum Gigeriae Galli and Squama Manis are respectively Fructus Aurantii (parched), Endothelium Corneum Gigeriae Galli (parched) and Squama Manis(parched); Radix Curcumae, Rhizoma Corydalis, Radix Bupleuri and Fructus Toosendan are respectively vinegar Radix Curcumae, vinegar Rhizoma Corydalis, Radix Bupleuri (processed with vinegar) and vinegar Fructus Toosendan; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis(processed with ginger).

Fructus Aurantii (parched) is a stir-baked Fructus Aurantii in bran, and per 50 kilograms of Fructus Aurantii sheets burn heat with pot earlier with 7.5 kilograms in Testa Tritici, evenly are sprinkled into quantitative Testa Tritici, and the moderate heat heating is treated that cigarette rises to pour the Fructus Aurantii sheet into, constantly stirs and fries to little yellow, takes out well sifted Testa Tritici, the cold of drying in the air.Fructus Aurantii can be removed partly volatile oil after Testa Tritici is fried, relax dry property and the acidity of living Fructus Aurantii, strengthens the regulating qi-flowing for harmonizing stomach effect.

Endothelium Corneum Gigeriae Galli (parched) is the stir-baking with sand Endothelium Corneum Gigeriae Galli, strengthens the effect of spleen invigorating removing food stagnancy behind the stir-baking with sand.

Squama Manis(parched) is the stir-baking with sand Squama Manis, and sand is put a pot internal heating, pours Squama Manis sheet of the same size into, fries with high heat to heaving to be yellow, takes out, and with ferrum sieve sieve shakeout, the time spent smashs to pieces.Stir-baking with sand can make medicinal substances ground become crisp, is easy to pulverize and fried active ingredient the performance curative effect.

The vinegar Radix Curcumae, per 50 kilograms of Radix Curcumaes are got clean Radix Curcumae with 10 kilograms of vinegar, mix thoroughly with vinegar, soak into to the vinegar exhaustion, put and steam in the cage thoroughly, take out, and cut thick transverse sheet of half point or oblique sheet, dry.Processed with vinegar can increase the dissolubility of volatile oil in water, and slow its toxicity, goes into liver with it, increases Radix Curcumae resolving depression pain-relieving functions.

The vinegar Rhizoma Corydalis, per 50 kilograms of Rhizoma Corydalis are chosen clean impurity with vinegar 7.5-10 kilogram, sieves anti-dandruffly, smash, and are exhausted to vinegar with the airtight stewing 3-4 of vinegar hour, fry extremely little yellow with slow fire, put to be used as medicine after cold.After the vinegar process of preparing Chinese medicine, alkaloid in the Rhizoma Corydalis and acetic acid are combined into acetate soluble in water, improve clinical efficacy.

Radix Bupleuri (processed with vinegar), per 50 kilograms of Radix Bupleuri are got the Radix Bupleuri sheet with 10 kilograms of vinegar, and are even with the vinegar spray, and little profit is put and is done in the pot, with the little stir-fry of slow fire, takes out the cold of drying in the air.Radix Bupleuri (processed with vinegar) rises the property mitigation of loosing, and has strengthened the dispersing the depressed liver-QI for alleviating pain effect.

The vinegar Fructus Toosendan, per 50 kilograms of Fructus Toosendans are chosen clean impurity with 7.5 kilograms of vinegar, smash, and mix thoroughly with vinegar, place in the pot, and the little stir-fry of slow fire is taken out, and dries.After concocting with vinegar, the Toosendanin, alkaloid etc. that are insoluble in water in the crude drug are had an effect with acetic acid, generate water-soluble acetate, the raising clinical efficacy.

Cortex Magnoliae Officinalis(processed with ginger), per 50 kilograms of Cortex Magnoliae Officinalis are got clean Rhizoma Zingiberis Recens section and are fried in shallow oil soup with 5 kilograms in Rhizoma Zingiberis Recens, add clean Cortex Magnoliae Officinalis, boil to soup exhaustion and saturating, take out, and chop up silk, dry.Strengthen the effect of preventing or arresting vomiting stomach function regulating, reduce zest.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation, and required various conventional adjuvant was prepared into any conventional oral preparations when the active component of medicine of the present invention was added the preparation different dosage form.For example these crude drug pulverize mix homogeneously can be made powder, pill or made capsule, tablet; Can or extract active component and make oral liquid these crude drug decoctings, condensed water decocting liquid, also can make powder, capsule etc. pulverizing behind the extracting solution concentrate drying.But these can not be used to limit protection scope of the present invention.

The generation of cholelithiasis is lacked of proper care relevant with liver, gallbladder, spleen three dirty physiological functions.Liver controlling conveyance and dispersion, the gallbladder master is logical to fall, and executes the gas of the few positive hair growth promoting of cloth, the lifting of turn spleen, transfer, the machine of fortuneization, gastric qi then with.The generation of cholelithiasis is fluctuation for a long time on the emotion, the surfeit delicious food, excessively easy, it is obstructed to block biliary tract, stagnation of YANG QI in the interior, the gas of the weary hair growth promoting of spleen, fortuneization is unable, and the machine that transfers lifting is dull, can not wet by drain water, causing in wet the storing in wet being stranded in sun, then yang-energy must not declare diffusing, strongly fragrant and heat-transformation, then heat is steamed in gallbladder, bile is fried in shallow oil, and is condensed into stone.Stone is desired to leak, and then goes up angina abdominis, tenderness, bitter taste, vomiting, fever of the body etc., then is converted into mechanism of qi for a long time to be obstructed, and qiactivity of triple energizer is unfavorable, turbid QI failing to descend, and the filling middle part of gastric cavity, so card is seen upper abdomen dull pain, bitter taste, nauseating, belch, arrow gas, appetite is not good enough etc.Medicine of the present invention catches cholelithiasis to block to cause the principal contradiction of " obstructed ", is the basis from the theory of the traditional Chinese medical science " the six hollow viscera must keep its unobstructed ", determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.

In the medicine of the present invention: forge Sal Nitri hard masses softening and resolving energy fossil, the Herba Lysimachiae cholagogic and lithagogue is used dissolving cholesterol, bile pigments and mixed calculus mutually, and the prevention cholelithiasis transfers bile duct and hepatic calculus to, then is monarch drug; The Endothelium Corneum Gigeriae Galli eliminating stagnation of stimulating the menstrual flow, spleen benefiting and stimulating the appetite, Natrii Sulfas Tongli are captured letting out pathogenic heat, collaborative monarch drug fossil, and Radix Scutellariae, Herba Artemisiae Scopariae, Fructus Gardeniae let out the liver and gall excess-fire clearly, and the dehumidifying jaundice eliminating then is a ministerial drug; Radix Bupleuri, Radix Curcumae, Cortex Magnoliae Officinalis, Rhizoma Corydalis, Fructus Toosendan, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Fructus Aurantii are with using depressed liver-energy dispersing and function of gallbladder promoting, regulating the flow of QI to alleviate depression, stopping nausea and vomiting by lowering the adverse flow of QI, removing mass pain relieving, matching then strengthens the gallbladder contractility, promotes the bile discharging, removes obstruction of bile duct, eliminating stenosis of bile duct, promote calculus to discharge, then is adjuvant drug; With Flos Lonicerae, Herba Taraxaci, Squama Manis, dried Alumen compatibility anti-inflammation then, eradicate the bile duct repeated infection, prevent that bile pigment calculus from producing, then be messenger drug.Form depressed liver-energy dispersing and QI regulating, clearing heat secreting bile, function of gallbladder promoting fossil, the novel drugs of the treatment cholelithiasis of anti-inflammatory analgetic.Suitably cooperate fat meal, can make biliary system form temporary high pressure, impact, impel cholelithiasis to discharge by bile.

The therapeutical effect of medicine of the present invention can reduce " change ", " moving ", " dashing ", " row " four steps.

" change " is the corner angleization circle that makes calculus, and be by sharp rust, little from bigization; " moving " is to induce calculus from quiet change, swings, from moving down; " dash " is to increase ballistic power, produce " torrent " or " vortex " and make calculus beat swing, the strength of this " dashing " can increase the narrow and spasm that the bile amount solves bile duct in moment, reach the effect of tonneau, " row " excretes calculus under the condition of changing, moving, dash.

Medicament composing prescription uniqueness of the present invention, prescription be rigorous, select YAOJING refining, and each component drug synergism complements each other, and overcome that to treat the cholelithiasis medicine long medicine time in the past, and calculus is slower, and effective percentage is low, cures the back and deficiencies such as " bounce-backs " occurs.

With Drug therapy cholelithiasis of the present invention, 20 days is a course of treatment, can cure general 1-2 course of treatment, and effective percentage is more than 98%, and cure rate is more than 94%, after the drug withdrawal not " bounce-back ".Have instant effect, short treating period, cure rate height, avirulence, characteristics such as safe and reliable, and raw material sources are abundant, manufacture method is simple, with low cost, are vast cholelithiasis patient's first-selected good medicine.

The specific embodiment

Below by embodiment and test example the present invention is further described.But the present invention is not limited to embodiment, and those of ordinary skills do some modification, all in protection domain of the present invention.

Embodiment 1-5: the preparation of medicine of the present invention " the pain relieving fossil looses "

(the unit: kilogram) see Table 1 of the consumption of each crude drug among each embodiment.

Preparation method: Fructus Aurantii, Endothelium Corneum Gigeriae Galli and the Squama Manis of described weight proportion are concocted into Fructus Aurantii (parched), Endothelium Corneum Gigeriae Galli (parched) and Squama Manis(parched) respectively; Radix Curcumae, Rhizoma Corydalis, Radix Bupleuri and Fructus Toosendan are concocted into vinegar Radix Curcumae, vinegar Rhizoma Corydalis, Radix Bupleuri (processed with vinegar) and vinegar Fructus Toosendan respectively; After Cortex Magnoliae Officinalis is concocted into Cortex Magnoliae Officinalis(processed with ginger), with all the other described materials of weight proportions medicines together, be developed into fine powder according to a conventional method again, behind the 100-120 mesh sieve, mix homogeneously is distributed into " the pain relieving fossil looses " that restrain for every bag 3 excessively.

Medicine of the present invention is the yellowish-brown powder, gas fragrance, bitter in the mouth.

Usage and dosage: boiled water is taken after mixing it with water, and 3 times on the one, each 1 bag, 20 days is 1 course of treatment.

Table 1

Embodiment number	1?	2?	3?	4?	5?
						Herba Lysimachiae	1.5?	2.0?	2.5?	3.0?	3.5?
Herba Artemisiae Scopariae	3.5?	3.0?	2.5?	2.0?	1.5?
						Fructus Gardeniae	0.9?	1.4?	1.5?	1.6?	2.1?
Forge Sal Nitri	0.9?	1.2?	1.5?	1.8?	2.1?
						Natrii Sulfas	1.2?	1.6?	2.0?	2.4?	2.8?
Fructus Aurantii	0.9?	1.3?	1.5?	1.6?	2.1?
						Radix Curcumae	1.6?	1.2?	2.0?	2.3?	2.8?

Cortex Magnoliae Officinalis	0.6?	0.8?	1.0?	1.2?	1.4?
						Rhizoma Corydalis	1.2?	1.5?	2.0?	2.3?	2.8?
Radix Scutellariae	0.8?	0.6?	1.0?	1.3?	1.4?
						Radix Bupleuri	0.9?	1.8?	1.5?	1.2?	2.1?
Dried Alumen	0.6?	0.8?	1.0?	1.2?	1.4?
						The Rhizoma Pinelliae	0.8?	0.6?	1.0?	1.4?	1.3?
The Radix Paeoniae Alba	2.1?	1.1?	1.5?	1.7?	0.9?
						Endothelium Corneum Gigeriae Galli	1.5?	2.0?	2.5?	3.5?	3.1?
Flos Lonicerae	1.5?	2.2?	2.5?	3.3?	3.5?
						Herba Taraxaci	2.0?	1.5?	2.5?	3.5?	3.0?
Fructus Toosendan	1.2?	1.5?	2.0?	2.3?	2.8?
						Squama Manis	0.9?	1.2?	1.5?	1.8?	2.1?

Test example: the clinical observation of medicine of the present invention " the pain relieving fossil looses " treatment cholelithiasis

1, physical data

Inventor 2002-2007 accepts outpatient service for medical treatment and is unfit to do operation or is reluctant the cholelithiasis patient that performs an operation totally 389 examples, male's 155 examples wherein, and women's 234 examples, at minimum 20 years old of age, maximum 80 years old, 30-60 year patient 305 examples accounted for 78.4%.

Medical history person below a year 121 examples, 2-10 206 examples, 11-20 62 examples.

Be diagnosed as 172 examples of cholelithiasis, 95 examples of liver and bile stone, 114 examples of cholecystitis, 8 examples of biliary postoperative syndrome.

Traditional Chinese medical science typing, Qi-stagnation type 329 examples, damp-heat type 60 examples.

2, Therapeutic Method

Oral embodiment 3 gained every day " the pain relieving fossil looses ".Each 1 bag (3 gram), 3 times on the one, boiled water is taken after mixing it with water.20 days is 1 course of treatment.

Patient with slight symptoms's conciliation that should be careful in one's diet, the treatment initial stage is given digestible low fat food, and the fat food of can suitably taking food after taking medicine 4-5 days to strengthen function of gallbladder promoting, brings out calculus; The patient with severe symptoms often needs fasting, gastrointestinal decompression and fluid infusion.Anti-harness the river, electrolyte and acid base imbalance, pay attention to the control of shock; Play pain below right costal margin can appear in the back patient that takes medicine, and times of defecation increases.When the yellow mucus loose stool appears in stool, should note having or not cholelithiasis to discharge, 7-15 days is the calculus climax after taking medicine, the calculus reaction can be arranged, increase slightly as slight heating, jaundice, leukocyte, suddenly right hypochondrial region exacerbates, and after taking medicine 1 hour, the fat meal of should taking food (for example eating 1 on Ungula Sus domestica) strengthens lithagogue effect.Second day colic symptoms disappears, and prove that calculus discharges, can note naughty stone from stool; Calculus is discharged back stomachache and is alleviated immediately, and body temperature descends.

Attention: weak, the careful usefulness of hepatic disfunction person; Anemia of pregnant woman's forbidding.

3, criterion

Calculosis treatment criterion

(1) cure: clinical symptoms, sign disappear, ultrasound diagnosis stone-echo group disappear and or the enhancing echo of gallbladder (pipe) wall thickness recover normally.

(2) take a turn for the better: clinical symptom disappearance or alleviate, ultrasound diagnosis stone-echo light group reduces more than 0.5 centimetre, increases thick bile duct internal diameter and reduces more than 0.2 centimetre, and it is normal that directly recover in the chamber.

(3) invalid: clinical symptoms, sign do not have change, and ultrasound diagnosis or check cholangiography do not have change.

The cholecystitis criterion of therapeutical effect

(1) cure: clinical symptoms, sign disappear, and it is normal that ultrasound diagnosis gallbladder size and form is recovered.

(2) produce effects: 4-5 days clinical symptoms of taking medicine and sign have obviously and alleviate, and ultrasound diagnosis has remarkable improvement.

(3) effective: after taking medicine 4-5 days, clinical symptoms and sign have certain improvement, and the ultrasound diagnosis gallbladder makes moderate progress.

(4) invalid: after medication 5-6 days, clinical symptoms and sign all do not have improvement.

4, therapeutic outcome

20 days is 1 course of treatment, and after taking medicine 40 days, the statistics therapeutic outcome is as table 2.

As can be seen from Table 2, in the clinical observation with Drug therapy cholelithiasis patient 389 examples of the present invention, 369 examples of healing account for 94.86%; 14 examples of produce effects, improvement account for 3.60%; 6 invalid examples account for 1.54%; Total effective rate 98.46%.

Invalid 6 examples are all changed hands the art treatment.4 examples are shown effect repeatedly, 1 routine perforation of gallbladder, and 1 example shock increases the weight of.

Table 2

Model case

Example 1: Wang, man 50 years old.May 4 calendar year 2001, not good enough because of right hypochondrial region is diagnosed as cholelithiasis through the western medicine effect, fall ill repeatedly more than 1 year, promptly feel upper right abdomen severe pain after the morbidity, heat, bitter taste, loss of appetite sometimes occur together.This time because of upper right abdomen severe pain, the cold fever that occurs together, vomiting and seek medical advice.

Health check-up: sanity, face dolorosa, body temperature 38.6 degree, blood pressure 109/75 millimetres of mercury, pulse 80 times/minute, the slight xanthochromia of sclera, tongue fur is white thick greasy, stringy and rolling pulse, chest cardiopulmonary no abnormality seen, abdominal part is smooth, upper right abdomen has obvious tenderness, stomach wall is nervous slightly, does not contact gallbladder below right costal margin, and the liver spleen does not all touch.Be diagnosed as the concurrent biliary tract infection of cholelithiasis (type expels the heat-evil).

Take " the pain relieving fossil looses ", each 1 bag of 3 gram, three times on the one, boiled water is taken after mixing it with water, clothes back pain are down alleviated gradually, pain relieving after a day, right hypochondrial region aggravation in the 9th day, hyperpyrexia, obvious xanthochromia appears in skin, sclera, takes " the pain relieving fossil looses " and eats 1 on Ungula Sus domestica later about 1 hour.Stomachache alleviated in the 10th day, the also more preceding alleviation of other symptom.From feces, wash in a pan out 6 of the big cholelithiasiss of Semen phaseoli radiati next day, after continue to discharge some mud sample calculus again.Took medicine symptom complete obiteration and fully recovering continuously 30 days.Confirm that through B ultrasonic cholelithiasis is emptying.

Example 2: Liu, man 55 years old.The patient right hypochondrial region occurs, and it is vexed indigestion and loss of appetite to feel breast gastral cavity painful abdominal mass gradually after accompanying a guest and having meal before first quarter moon, abdominal distention, spiritlessness and weakness, after gradually occur together burning, feel cold, vomit, can not take food, it is invalid to take the Western medicine a few days.After due to illness feelings aggravation, slight coma appears, speaking incoherently, sclera, yellowing of the skin and examine.

Health check-up: face dolorosa, absentminded, body temperature 39.5 degree, blood pressure 100/60 millimetres of mercury, pulse 123 times/minute, tachypnea, sclera, the obvious xanthochromia of skin, dry fur on tongue is greasy, slippery and rapid pulse.The chest cardiopulmonary show no obvious abnormalities.Abdominal part is full, and upper right abdomen has obvious tenderness, and the abdominal part anxiety can contact the gallbladder of enlargement below right costal margin, and the liver spleen does not touch.

Laboratory examination: leukocyte 16.2 * 10 ⁹/ L, neutrophilic granulocyte 0.02, urine bilirubin (++), urobilinogen (±) Urobilin (-).

Clinical diagnosis: the concurrent toxic shock of cholelithiasis (toxic type)

Award venous transfusion immediately, use antibiotic, hormone etc., take " the pain relieving fossil looses " simultaneously.The state of an illness takes a turn for the better rapidly after 24 hours, the basic shock of correcting.Right upper quadrant of the abdomen began severe pain in the 13rd day, was that calculus disease resembles, and took medicine and gave fat meal about 1 hour.Began to wash in a pan out from feces volume silt sample cholelithiasis on the 14th day, the state of an illness takes a turn for the better rapidly behind the calculus.Through controlling 35 days, the symptom complete obiteration confirms that through the B ultrasonic check cholelithiasis is emptying.

Example 3: Xu so-and-so, woman 67 years old.First visit on April 6 in 2002.Right flank pain 4 years is surplus, and the paroxysmal outbreak increased the weight of in nearly 4 days.Examine and see: the heating nausea and vomiting, it is glossy that appearance and whole skin are crocus, and the urine yellow skin is red, constipation, red tongue, yellow and greasy fur, wiry and frequent pulse.A corpse or other object for laboratory examination and chemical testing: body temperature 38 degree, blood pressure 100/60 millimetres of mercury, upper right abdominal pressure pain is obviously, Murphy's sign (+) touches following 3 centimetres of 2 centimetres, xiphoid-process under the rib of the liver left and right sides, matter is medium, icteric index 60 units, B ultrasonic prompting gallbladder increases, gallbladder is interior, the interior calculus companion of right common hepatic duct hypomere extrahepatic biliary passages blocks.Tcm diagnosis: liver gallbladder damp-heat type hypochondriac pain, jaundice, Western medicine diagnose: acute episode of chronic cholecystitis.Take " the pain relieving fossil loose ", each 1 bag of 3 gram, 3 times on the one, boiled water is taken after mixing it with water.The 5th day, body temperature was normal, and hypochondriac pain alleviates, and the 15th day, hypochondriac pain disappeared, and jaundice disappears, and urinates three gallbladders (-).20 days check livers, except that Iod R (±), remainder is all normal, B ultrasonic, gallbladder more obviously dwindled, and calculus is discharged, cures.

Example 4: Zhao so-and-so, woman 42 years old.First visit on May 11 in 2004: in 1 week of right side abdominal and hypochondriac pain, be the persistence aggravation.Fever with aversion to cold, bitter taste is felt sick, anorexia, constipation, Jian Bei Paralysis Chu.Body is looked into: body temperature 39.1 degree, and the slight xanthochromia of eye conjunctiva, Murphy's sign (+), 12800/ cubic millimeter of leukocyte, the Urobilin positive, the red matter of gallbladder is weak positive, ultrasound wave prompting acute cholecystitis, tongue is greasy in vain, wiry and frequent pulse.Diagnosis: damp and hot fumigation liver and gall type, the rule of treatment: clearing away heat and eliminating dampness, depressed liver-energy dispersing and function of gallbladder promoting.Take " the pain relieving fossil looses ", each 1 bag of 3 gram, 3 times on the one, boiled water is taken after mixing it with water.After 3 days, cold and heat all move back, and the gastral cavity hypochondriac pain is slow.After 8 days, all cards are known flat, and it is normal that ultrasonic check gallbladder recovers, and cures.

Example 5: Zheng, woman, 39 years old.In winter calendar year 2001, cholelithiasis is through four operations, existing angor takes place again, through the doctor trained in Western medicine inspection, is diagnosed as the cholelithiasis recurrence, because of the affected part wound in length and breadth, cicatrix is staggered, can't go operation again, advises the commentaries on classics Chinese traditional treatment.Take " the pain relieving fossil looses ", each 1 bag of 3 gram, 3 times on the one, boiled water is taken after mixing it with water.Clothes back pain relief serve on 25 days, and pain is flat entirely.From then on work as usual, work is adhered in not recurrence in 7 years so far all the year round, is as healthy as usual.

Example 6: Liu so-and-so, woman, 28 years old.Prominent sense of in June, 1999 epigastrium pain is felt sick during inappetence, through certain institute's ultrasonic examination: 3.5-4 centimetre of gallbladder fluid level, cyst wall thickens, and gives the 654-2 intramuscular injection, treatments such as oral cholic acid is received, XIAOYAN LIDAN PIAN, the aggravation of pain gesture, certain hospital is hospitalized for treatment with cholecystitis, cholelithiasis.Be admitted to hospital after curative effects such as Western medicine antiinflammatory, calculus do not show, advise the commentaries on classics tcm diagnosis and treatment.This disease is pressed the Chinese medical discrimination diagnosis: the QI stagnation of the liver and galibladder type.The cause of disease: QI stagnation of the liver and galibladder, bile Cheng Shi is endured in damp and hot friendship resistance.The rule of treatment: depressed liver-energy dispersing and QI regulating, clearing heat secreting bile, the stagnant fossil of row.Take " the pain relieving fossil loose ", each 1 bag of 3 gram, 3 times on the one, boiled water is taken after mixing it with water.After 5 days, the light food of pain increases.After the 10th day, all diseases disappear.For consolidating its effect, continued to take medicine 10, cut dose with disease increasing, make the thorough removing of cholelithiasis not stay future trouble.

Claims (4)

1. medicine for the treatment of cholelithiasis is characterized in that being made by following bulk drugs:

Herba Lysimachiae 15-35 part, Herba Artemisiae Scopariae 15-35 part, Fructus Gardeniae 9-21 part, forge Sal Nitri 9-21 part, Natrii Sulfas 12-28 part, Fructus Aurantii 9-21 part, Radix Curcumae 12-28 part, Cortex Magnoliae Officinalis 6-14 part, Rhizoma Corydalis 12-28 part, Radix Scutellariae 6-14 part, Radix Bupleuri 9-21 part, dried Alumen 6-14 part, Rhizoma Pinelliae 6-14 part, Radix Paeoniae Alba 9-21 part, Endothelium Corneum Gigeriae Galli 15-35 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, Fructus Toosendan 12-28 part, Squama Manis 9-21 part.

2. the medicine of treatment cholelithiasis according to claim 1 is characterized in that being made by following bulk drugs:

Herba Lysimachiae 20-30 part, Herba Artemisiae Scopariae 20-30 part, Fructus Gardeniae 12-18 part, forge Sal Nitri 12-18 part, Natrii Sulfas 16-24 part, Fructus Aurantii 12-18 part, Radix Curcumae 16-24 part, Cortex Magnoliae Officinalis 8-12 part, Rhizoma Corydalis 16-24 part, Radix Scutellariae 8-12 part, Radix Bupleuri 12-18 part, dried Alumen 8-12 part, Rhizoma Pinelliae 8-12 part, Radix Paeoniae Alba 12-18 part, Endothelium Corneum Gigeriae Galli 20-30 part, Flos Lonicerae 20-30 part, Herba Taraxaci 20-30 part, Fructus Toosendan 16-24 part, Squama Manis 12-18 part.

3. the medicine of treatment cholelithiasis according to claim 1 is characterized in that being made by following bulk drugs:

25 parts of Herba Lysimachiaes, 25 parts of Herba Artemisiae Scopariaes, 15 parts of Fructus Gardeniaes, forge 15 parts on Sal Nitri, 20 parts in Natrii Sulfas, 15 parts of Fructus Aurantiis, 20 parts of Radix Curcumaes, 10 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Corydalis, 10 parts of Radix Scutellariaes, 15 parts of Radix Bupleuri, 10 parts of dried Alumens, 10 parts of the Rhizoma Pinelliaes, 15 parts of the Radix Paeoniae Albas, 25 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Flos Loniceraes, 25 parts of Herba Taraxacis, 20 parts of Fructus Toosendans, 15 parts of Squama Maniss.

4. according to the medicine of claim 1 or 2 or 3 described treatment cholelithiasis, it is characterized in that:

Fructus Aurantii, Endothelium Corneum Gigeriae Galli and Squama Manis are respectively Fructus Aurantii (parched), Endothelium Corneum Gigeriae Galli (parched) and Squama Manis(parched); Radix Curcumae, Rhizoma Corydalis, Radix Bupleuri and Fructus Toosendan are respectively vinegar Radix Curcumae, vinegar Rhizoma Corydalis, Radix Bupleuri (processed with vinegar) and vinegar Fructus Toosendan; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis(processed with ginger).