CN104623118A - Toxicity-eliminating and urinary calculus-removing preparation for treating bile duct stones due to dampness-heat of liver and gallbladder and preparation method thereof - Google Patents

Abstract

The invention discloses a toxicity-eliminating and urinary calculus-removing preparation for treating bile duct stones due to dampness-heat of liver and gallbladder. The preparation is prepared from the following main raw materials in parts by weight: 15-30 parts of felwort, 10-20 parts of endothelium corneum gigeriae galli, 8-16 parts of ginger-processed cape jasmine, 20-30 parts of astragalus membranaceus, 8-16 parts of centipeda minima, 8-12 parts of melia toosendan, 7-14 parts of sculellaria barbata, 9-13 parts of cuttle bone, 6-9 parts of salvia chinensis, 5-9 parts of aralia decaisneana hance, 5-10 parts of oldenlandia diffusa, 7-12 parts of gynostemma pentaphylla, 9-15 parts of slaked lime, 3-6 parts of ovateleaf holly bark, 4-9 parts of whiteflower violet herb with root and 8-12 parts of licorice root. The preparation has the efficacy of clearing heat and removing dampness, promoting bile flow and removing calculus, dispersing stagnated liver qi for promoting bile flow, and activating vital energy to stop pain, can directly, rapidly and completely act on the lesion, and can be used for resolving hard lump, rapidly dissolving stones from the outside to inside, and quickly relieving and eliminating pain, swelling and other symptoms caused by in vivo stones.

Description

Liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament and method for making.

Background technology

Calculus of bile duct refers in extrahepatic duct have calculus, is modal biliary tract disease.Calculus is blocked bile duct and is caused cholestasis, secondary bacterial infection and cause acute cholangitis to occur.Bile duct repeatedly inflammation can cause local tube wall thickening or cicatrical narrow, and bile duct inflammation and narrowly can promote calculus.Cholelithiasis is China's commonly encountered diseases, and sickness rate is about about 10%, and the generation of this disease is relevant with biliary tract ascarid, biliary tract infection and obstruction of biliary tract.Calculus of bile duct is divided into primary cholelithiasis and Secondary cases calculus of bile duct, and primary cholelithiasis means the calculus formed in bile duct, is mainly bile pigment calculus or mixed calculus.Secondary cases calculus of bile duct is the cholelithiasis person that drains into common bile duct, is mainly cholesterol calculus.Extrahepatic biliary stone and calculus of intrahepatic duct is divided into according to position, calculus place.Extrahepatic biliary stone multidigit is in distal common bile duct; Calculus of intrahepatic duct can be distributed widely in two leaf stones in intrahepatic bile duct or be confined to certain leaf bile duct, wherein with left outside leaf and right back leaf common.When calculus block bile duct and secondary infection time, its typical clinical manifestation is Charcot triad, namely suffers from abdominal pain, shiver with cold high heat and jaundice.Infect and seriously can occur shock and psychological problem, symptom is repeatedly of a specified duration there is biliary cirrhosis, then occurs portal hypertension.

Calculus of bile duct brings a lot of inconvenience to patient, and the biliary colic of 90% breaks out, and pain symptom is often positioned at the position of epigastrium or upper right abdomen, and can emit to shoulder and back.Usually be easy to occur in eat very full time, after overworked or strenuous exercise, also have some patients may send out disease suddenly at night.Except the symptom had an intense pain, often have uneasy in either sitting or lying, even toss about, dripping sweat, pale complexion etc. some performance, also can there is nausea and vomiting etc.Each outbreak generally can continue for some time, and often needs could alleviate for a long time.

The method of existing Chinese traditional treatment calculus of bile duct is also many, for the problems referred to above, publication number CN103495116 A (application number 201310453953.9) patent document discloses a kind of Chinese medicine for the treatment of calculus of intrahepatic duct, and its composition weight proportioning is: monarch drug-Talcum l50 part, Endothelium Corneum Gigeriae Galli 40 parts, Herba Lysimachiae 40 parts, Concha Ostreae 30 parts; Ministerial drug-Rhizoma Atractylodis Macrocephalae l5 part, Fructus Crataegi 15 parts, Radix Curcumae 12 parts, 10 parts, Lignum Santali Albi, Fructus Amomi 8 parts, Fructus Aurantii 12 parts, Rhizoma Polygoni Cuspidati 20 parts, Fructus Toosendan 12 parts, Rhizoma Cyperi 10 parts, Radix Bupleuri 15 parts; Adjuvant drug-Radix Paeoniae Alba 30 parts, Radix Salviae Miltiorrhizae 30 parts, bulky l2 part, Rhizoma Corydalis 15 parts, Pollen Typhae l2 part, Oletum Trogopterori l5 part, Radix Linderae l5 part, Aspongopus l5 part; Make medicine-Oldenlandia diffusa Roxb 30 parts, Herba Patriniae 30 parts, Herba Taraxaci 10 parts, Semen Phaseoli 30 parts, Os Draconis 30 parts, Caulis Akebiae l5 part, liana Spora Lygodii 30 parts, Herba Artemisiae Scopariae 30 parts, Radix Scutellariae 15 parts; Processing technique: above-mentioned medical material removing impurity, moisture content are put into cast iron pan and repeatedly fried to clear-cut; Drop in pulverizer and pulverize, cross dusting cover.Publication number CN 101342350 A (application number 200810032163.2) patent document discloses a kind of medicine for the treatment of calculus, this medicine comprises Herba Lysimachiae 130-170 part (weight portion, lower same), Folium Pyrrosiae 80-120 part, Spora Lygodii 130-170 part, Semen Abutili 80-120 part, succinum 80-120 part, Rhizoma Chuanxiong 80-120 part, Radix Curcumae 80-120 part, Radix Aucklandiae 40-80 part, Rhizoma Corydalis 80-120 part, Rhizoma Sparganii 40-80 part, Endothelium Corneum Gigeriae Galli 130-180 part, Gryllotalpa 100-140 part, Radix Glycyrrhizae 60-100 part, Rhizoma Curcumae 40-80 part, said medicine dries rear common pulverizing respectively, stir, after crossing 100 mesh sieves, incapsulate.Publication number CN 101721656 A(application number 200810224635.4) patent document discloses a kind of pharmaceutical composition for the treatment of calculus and preparation method thereof, the crude drug of this pharmaceutical composition consists of: A group: Radix Curcumae 30-90 weight portion, Rhizoma Alismatis 30-90 weight portion, Folium Pyrrosiae 30-90 weight portion, Fructus Toosendan 50-150 weight portion, Herba Lysimachiae 75-225 weight portion, Radix Paeoniae Rubra 30-90 weight portion, Radix Astragali 50-150 weight portion; B group: Spora Lygodii 75-225 weight portion, Borneolum Syntheticum 10-30 weight portion.

The prior art comprising above-mentioned patent documentation all achieves certain achievement to the research of calculus of bile duct mechanism and treatment, but yet there is many deficiencies.Mostly traditional operation treatment is cut-out gallbladder, very harmful to health.Extracorporeal shock wave is through clinical proof, dangerous high, easily causes rubble to block bile duct, falls into many serious consequences such as esophagus.Western medicine as one independently Therapeutic Method, can not can only play the auxiliaring effect of anti-inflammatory analgetic, cannot melt calculus.

Summary of the invention

For the deficiency of existing treatment calculus of bile duct, an object of the present invention is to provide a kind of liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, directly, fast, fully can act on focus, hard masses softening and resolving, rapid solution calculus from outside to inside, the symptom such as pain, swelling that alleviation rapidly, elimination calculi in vivo cause.Another object is just to provide the preparation method of above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, takes off the primary raw material stating weight proportion and is prepared from: Radix Gentianae 15-30 part; Endothelium Corneum Gigeriae Galli 10-20 part; Rhizoma Zingiberis Recens Fructus Gardeniae 8-16 part; Radix Astragali 20-30 part; Herba Centipedae 8-16 part; Fructus Toosendan 8-12 part; Herba Scutellariae Barbatae 7-14 part; Os Sepiae 9-13 part; Herba Salviae Chinensis 6-9 part; Aralia decaisneana Hance 5-9 part; Herba Hedyotidis Diffusae 5-10 part; Herb Gynostemmae Pentaphylli 7-12 part; Sal Nitri 9-15 part; Cortex Ilicis Rotundae 3-6 part; Herba violae patrinii 4-9 part; Radix Glycyrrhizae 8-12 part.

Liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Gentianae 20-25 part; Endothelium Corneum Gigeriae Galli 13-17 part; Rhizoma Zingiberis Recens Fructus Gardeniae 11-13 part; Radix Astragali 23-27 part; Herba Centipedae 11-13 part; Fructus Toosendan 9-11 part; Herba Scutellariae Barbatae 9-12 part; Os Sepiae 10-12 part; Herba Salviae Chinensis 7-8 part; Aralia decaisneana Hance 6-8 part; Herba Hedyotidis Diffusae 6-9 part; Herb Gynostemmae Pentaphylli 8-11 part; Sal Nitri 11-13 part; Cortex Ilicis Rotundae 4-5 part; Herba violae patrinii 5-8 part; Radix Glycyrrhizae 9-11 part.

Liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Gentianae 22 parts; Endothelium Corneum Gigeriae Galli 15 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 12 parts; The Radix Astragali 25 parts; Herba Centipedae 12 parts; Fructus Toosendan 10 parts; Herba Scutellariae Barbatae 11 parts; Os Sepiae 11 parts; Herba Salviae Chinensis 7.5 parts; Aralia decaisneana Hance 7 parts; Herba Hedyotidis Diffusae 7 parts; Herb Gynostemmae Pentaphylli 9 parts; Sal Nitri 12 parts; Cortex Ilicis Rotundae 4.5 parts; Herba violae patrinii 6 parts; 10 parts, Radix Glycyrrhizae.

Present invention also offers the preparation method above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament being made pharmaceutically acceptable decoction, granule, Tablet and Capsula.

The preparation method of described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament decoction, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, high temperature sterilization 20-40 minute, sterile packaged.

According to preparation method recited above, preferred scheme is: step (5) high temperature sterilization 25-35 minute, is more preferably, high temperature sterilization 30 minutes.

Instructions of taking: each 200-300ml, every day 2 times, 5 days courses for the treatment of.

The preparation method of described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus pharmacy particle agent, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) by step (3) and step (4) gained liquid mixing even, be concentrated into relative density 1.20-1.40(preferred, be concentrated into relative density 1.25-1.35, be more preferably, be concentrated into relative density 1.30), add starch, mix homogeneously, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, encapsulate with the specification of every parcel 6g.

According to preparation method recited above, preferred scheme is: the consumption of step (5) starch is the 10%-20% of medicated powder gross mass, is more preferably, and the consumption of starch is 15% of medicated powder gross mass.

Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 5 days courses for the treatment of.

The preparation method of described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament tablet, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.20-1.40, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

According to preparation method recited above, preferred scheme is: step (5) is concentrated into relative density 1.25-1.35, is more preferably, and is concentrated into relative density 1.30.

Instructions of taking: each 1-2 sheet, every day 3 times, 5 days courses for the treatment of.

The preparation method of described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus drug capsule, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.10-1.30 thick paste (preferred, be concentrated into the thick paste of relative density 1.15-1.25, be more preferably, be concentrated into the thick paste of relative density 1.20), dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

Using method: each 1-2 grain, every day 3 times, 5 days courses for the treatment of.

Liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament of the present invention has effect of clearing away heat-damp and promoting diuresis, cholagogic and lithagogue, 'Shugan Lidan ', promoting the circulation of QI to relieve pain.Directly, fast, fully can act on focus, hard masses softening and resolving, from outside to inside rapid solution calculus, the symptom such as pain, swelling that alleviation rapidly, elimination calculi in vivo cause.The increase of hepatic bile secretory volume can be promoted, improve acid or alkali environment in human body, divide stone nuclear in a short time, make calculus in human body gradually cracked, melt, eliminate.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

The pharmacological effect of each crude drug is respectively:

Radix Gentianae: bitter in the mouth, cold in nature.Return liver, gallbladder meridian.For Gentianaceae root welding technology gentianaceous.There is heat clearing and damp drying, effect of eliminating pathogen in the liver arresting convulsion.For jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear swells, hypochondriac pain bitter taste, calentura convulsion with spasms.

Endothelium Corneum Gigeriae Galli: sweet in the mouth, property is put down.Return spleen, stomach, small intestinal, urinary bladder channel.For the dry inner wall of sandbag of Phasianidae animal man chicken.There is invigorating the stomach and promoting digestion, effect of arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.

Rhizoma Zingiberis Recens Fructus Gardeniae: the processed goods being Fructus Gardeniae.And be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen channel.For the dry root of leguminous plant Radix Astagali or Radix Astragali.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.

Herba Centipedae: acrid in the mouth, warm in nature.Return lung, Liver Channel.For the dry herb of feverfew Herba Centipedae.There is clearing the nasal passage, effect of cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.

Fructus Toosendan: call as Fructus Toosendan, Fructus Toosendan, Fructus Toosendan reality.For the dry mature fruit of Meliaceae plant Fructus Toosendan, primary medicinal component is Fructus Toosendan element, alkaloid etc.Gather during fruit maturation in winter, removing impurity, dry.Bitter in the mouth, cold in nature.Return liver, small intestinal, urinary bladder channel.There are soothing liver-QI promoting the circulation of QI to relieve pain, effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.Bitter cold is fallen and is let out, can clearing away liver-fire, let out hot and suffocating, promoting the circulation of QI to relieve pain.

Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature.Return lung, liver, kidney channel.For the dry herb of labiate Herba Scutellariae Barbatae.There is heat-clearing and toxic substances removing, effect of blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.

Os Sepiae: salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.For the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Containing calcium carbonate more than 85%, in addition, 17 seed amino acids such as methionine, aspartic acid, glutamic acid are contained in inner shell.There is astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, effect of sore.For Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.

Herba Salviae Chinensis: acrid in the mouth, hardship, cold nature.Return liver, spleen channel.Having another name called Salvia chinensis, is the herb of labiate Salvia chinensis.Containing different salvianolic acid, salvianolic acid B, D, Radix Arnebiae (Radix Lithospermi) phenolic acid, rosmarinic acid, caffeic acid, protocatechualdehyde, oleanolic acid, in addition containing sterol, Triterpenoid etc.There is blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, effect of mass dissipating and swelling eliminating.For menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, has blood in stool, jaundice due to damp-heat, hot toxic-heat and blood stasis, drenches pain, leukorrhagia, rheumatic ostalgia, scrofula, and skin ulcer swells, acute mastitis, herpes zoster, leprosy, and traumatic injury wound is swollen.

Aralia decaisneana Hance: bitter in the mouth, pungent, property is put down.For the root of Araliaceae Aralia decaisneana Hance.Han chikusetsusaponin, oleanolic acid-3-O [α-L-Arab (1-4)]-β-D glucuronide.There is expelling wind and removing dampness, promoting blood circulation to restore menstrual flow, effect of removing toxic substances and promoting subsidence of swelling.For anemopyretic cold headache, cough, rheumatic arthralgia, waist and leg ache, jaundice due to damp-heat, edema, stranguria with turbid discharge, leukorrhagia, amenorrhea, puerperal exposure to wind pain, treating swelling and pain by traumatic injury, gastric abscess, laryngopharynx swelling and pain, gingival swelling and pain.

Herba Hedyotidis Diffusae: mildly bitter flavor, micro-sweet, cold nature.GUIXIN, liver, spleen channel.For the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae.Herb containing rubichloric acid., rubichloric acid. acid, remove the acid of acetate rubichloric acid., all square rafter glycoside acid, Herba Paederiae time glycoside, Herba Paederiae time glycoside methyl ester, 6-O-p-hydroxyl cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-p-methoxyl group cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-Resina Ferulae acyl Herba Paederiae time glycoside methyl ester, 2-methyl-3-hydroxyanthraquinone, 2-methyl-3-methoxy anthraquinone etc.There is heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, effect of inducing diuresis to remove edema.For laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, the puckery pain of pyretic stranguria, jaundice due to damp-heat, venom, skin ulcer swells hot carbuncle.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature.Return lung, spleen, kidney channel.For Cucurbitaceae is overgrow the Herb of herbaceous plant Herb Gynostemmae Pentaphylli and multiple congener.Another name: Herba Gynostemmatis, Pentapanax, gynostemma pentaphyllum makino, Herba Gynostemmatis etc.Containing multiple Ginsenosides, there is the function of similar Radix Ginseng.There is QI invigorating, calm the nerves, blood pressure lowering, heat-clearing and toxic substances removing, effect of eliminating phlegm and stopping cough.Weak for body void, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, chronic gastroenteritis, chronic tracheitis.

Sal Nitri: bitter in the mouth, salty, warm in nature.GUIXIN, spleen two warp.Another name taste Natrii Sulfas, change metal and stone, be the crystallization of Sal Nitri through processing refining, main component is potassium nitrate.Have broken hard loose long-pending, under diuresis is rushed down, effect of removing toxic substances and promoting subsidence of swelling.Be used for the treatment of trusted subordinate's pain, vomit and diarrhoea, jaundice, gonorrhea, furunculosis, the diseases such as carbuncle.

Cortex Ilicis Rotundae: bitter in the mouth, cool in nature.Return lung, liver, large intestine channel.Another name: silver bark, Semen Sterculiae Nobilis, white orchid are fragrant, Fel Ursi is wooden.For bark or the root bark of holly plant Ilex rotunda Thunb..Containing flavonoid glycoside, phenols, tannin, Triterpene Glycosides, and isolate β-Amyrin, cupreol and stearic acid.Leaf contains flavonoid glycoside, phenols, aminoacid, saccharide, triterpene.Seed is containing oleanolic acid, rotundic acid.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flu, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, rheumatic ostalgia; Traumatic injury is controlled in external, carbuncle furuncle infections, traumatic hemorrhage, burn and scald.

Herba violae patrinii: acrid in the mouth, micro-hardship, cold in nature.Return large intestine, the heart, Liver Channel.For Violaceae plant spends Herba Violae, the herb of viola inconspicua Blume or Nepal's common violet or whole herb with root in vain.There is heat-clearing and toxic substances removing, effect of dissipating blood stasis for subsidence of swelling.For acute appendicitis, furuncle, red and swollen sore, jaundice, stranguria with turbid discharge, order is raw nebula also.

Radix Glycyrrhizae: sweet in the mouth, property is put down.GUIXIN.Lung, spleen, stomach warp.For the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

embodiment 1liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, takes off and states primary raw material and be prepared from (getting 50g for every part): Radix Gentianae 15 parts; Endothelium Corneum Gigeriae Galli 10 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 8 parts; The Radix Astragali 20 parts; Herba Centipedae 8 parts; Fructus Toosendan 8 parts; Herba Scutellariae Barbatae 7 parts; Os Sepiae 9 parts; Herba Salviae Chinensis 6 parts; Aralia decaisneana Hance 5 parts; Herba Hedyotidis Diffusae 5 parts; Herb Gynostemmae Pentaphylli 7 parts; Sal Nitri 9 parts; Cortex Ilicis Rotundae 3 parts; Herba violae patrinii 4 parts; 8 parts, Radix Glycyrrhizae.

The preparation method of above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament decoction, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (slice thickness is 3mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, remove coarse toilet paper, be ground into fine powder;

(3) by the grinding of Rhizoma Zingiberis Recens Fructus Gardeniae, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3 times amount 30%, percolation, collect percolate, leave standstill 8 hours, filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 50 minutes, add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, each 40 minutes, merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, high temperature sterilization 30 minutes, sterile packaged.

Instructions of taking: each 200-300ml, every day 2 times, 5 days courses for the treatment of.

model case one:xX suddenly, man, 37 years old, people from Huaiyin District, Jinan City, Shandong Province.Suffer from calculus of intrahepatic duct 10 years soon.Before 2 years, he starts to occur Upper abdominal pain, goes to a doctor to local hospital, and after CT examination, doctor, to having opened a little medicine, takes medicine invalid rear drug withdrawal.In the ensuing time, pain is often shown effect, and the pressure of Mr. Huo is very large, and also very irritated, when having an attack of one's old illness, mood all can be more overcast at every turn.And paroxysmal pain all can appear in his abdominal part substantially every several days, also often emit to back and shoulder, sometimes upper right half body, particularly back, just as numbness, be afraid of cold with fever once in a while.

Take embodiment 1 gained liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament decoction, Mr. Huo recovers very fast, and after having taken 1 course for the treatment of, stable disease, paroxysmal pain frequency obviously reduces.After continuing to take 2 courses for the treatment of, Mr.'s Huo bile mesobilirubin and glycoprotein fraction reduce to go examination in hospital to find, cholic acid increases, and this shows, while treatment calculus of bile duct, also to serve the effect that prevention cholelithiasis is formed, and efficiently avoid cholelithiasis recurrence.Visit after 1 year and learn and fully recover, do not recur.

embodiment 2liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, takes off and states primary raw material and be prepared from (getting 30g for every part): Radix Gentianae 20 parts; Endothelium Corneum Gigeriae Galli 13 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 11 parts; The Radix Astragali 23 parts; Herba Centipedae 11 parts; Fructus Toosendan 9 parts; Herba Scutellariae Barbatae 9 parts; Os Sepiae 10 parts; Herba Salviae Chinensis 7 parts; Aralia decaisneana Hance 6 parts; Herba Hedyotidis Diffusae 6 parts; Herb Gynostemmae Pentaphylli 8 parts; Sal Nitri 11 parts; Cortex Ilicis Rotundae 4 parts; Herba violae patrinii 5 parts; 9 parts, Radix Glycyrrhizae.

The preparation method of above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus pharmacy particle agent, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (slice thickness is 3mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, remove coarse toilet paper, be ground into fine powder;

(3) by the grinding of Rhizoma Zingiberis Recens Fructus Gardeniae, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3 times amount 33%, percolation, collect percolate, leave standstill 8 hours, filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 50 minutes, add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, each 40 minutes, merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.30, add starch, mix homogeneously, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, encapsulate with the specification of every parcel 6g.

Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 5 days courses for the treatment of.

model case two:king XX, female, 42 years old, Zibo City of Shandong Province from Huantai County.Right upper quadrant of the abdomen is painful sad also draws back, under xiphoid-process and right upper quadrant of the abdomen tenderness obvious, swollen indigestion and loss of appetite with gastral cavity, constipation, without rebound tenderness, hepatic region knocking is comparatively bitterly.B ultrasonic shows: right stones in intrahepatic bile duct microlith.Disease is seen: shallow complexion, epigastrium pain, draws right back, the severe pain of pressure, oppression sensation over the epigastrium and anorexia, dizzy nausea, and lower limb acid is firmly unable, sleeps night and feels unwell.Be diagnosed as Calculus of bile duct with cholecystitis.

Take embodiment 2 gained liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus pharmacy particle agent second day, stool rushes down lower 2 times, and after having taken 1 course for the treatment of, right hypochondrial region is clearly better, and diet improves, but still effectively tired out, sleeps night and feels unwell.After continuing to take 2 courses for the treatment of, clinical symptoms disappears substantially, and during defecation, discharge sandstone is as large in Kidney bean.B ultrasonic is checked: calculus of intrahepatic duct disappears.Follow up a case by regular visits to and have no a recurrence in.

embodiment 3liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Gentianae 25 parts; Endothelium Corneum Gigeriae Galli 17 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 13 parts; The Radix Astragali 27 parts; Herba Centipedae 13 parts; Fructus Toosendan 11 parts; Herba Scutellariae Barbatae 12 parts; Os Sepiae 12 parts; Herba Salviae Chinensis 8 parts; Aralia decaisneana Hance 8 parts; Herba Hedyotidis Diffusae 9 parts; Herb Gynostemmae Pentaphylli 11 parts; Sal Nitri 13 parts; Cortex Ilicis Rotundae 5 parts; Herba violae patrinii 8 parts; 11 parts, Radix Glycyrrhizae.

The preparation method of above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament tablet, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (slice thickness is 5mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, remove coarse toilet paper, be ground into fine powder;

(3) by the grinding of Rhizoma Zingiberis Recens Fructus Gardeniae, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 5 times amount 37%, percolation, collect percolate, leave standstill 8 hours, filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 50 minutes, add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, each 40 minutes, merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.30, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Using method: each 1-2 sheet, every day 3 times, 5 days courses for the treatment of.

model case three:poplar XX, female, 49 years old, people from Middle District of Zaozhuang City.Right hypochondrial region recurrent exerbation for many years, because cholelithiasis carried out operation before 4 years, postoperative biliary colic transference cure.Started before 2 years to occur upper right angina abdominis, cause after greasy more than feed, without heating and jaundice symptom.Stomachache outbreak is frequent, occasionally has shiver with cold, heating.Angina abdominis in about 2 months front rights, companion's mild skin xanthochromia, urine color depth, alleviates after infusion treatment.But there is not again above-mentioned symptom in a few days, in the ensuing time again and again.Have a medical check-up: abdomen is smooth, as seen below right costal margin and upper abdomen paramedian incision cicatrix, upper right abdominal pressure pain, bilirubin 30umol/L, bilirubin direct 14.90umol/L, is diagnosed as calculus of bile duct.

After taking embodiment 3 gained liver gallbladder damp-heat type calculus of bile duct removing toxic substances 1 course for the treatment of of calculus medicament tablet, upper right angina abdominis symptom is eased, but still weak with dizziness.Continue to take 2 courses for the treatment of, various malaise symptoms obviously disappears, and spirit is clearly better, and appetite strengthens, and knows on inspection and has reached clinical cure.Later stage visits and learns and fully recover, and does not recur.

embodiment 4liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Gentianae 22 parts; Endothelium Corneum Gigeriae Galli 15 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 12 parts; The Radix Astragali 25 parts; Herba Centipedae 12 parts; Fructus Toosendan 10 parts; Herba Scutellariae Barbatae 11 parts; Os Sepiae 11 parts; Herba Salviae Chinensis 7.5 parts; Aralia decaisneana Hance 7 parts; Herba Hedyotidis Diffusae 7 parts; Herb Gynostemmae Pentaphylli 9 parts; Sal Nitri 12 parts; Cortex Ilicis Rotundae 4.5 parts; Herba violae patrinii 6 parts; 10 parts, Radix Glycyrrhizae.

The preparation method of above-mentioned liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus drug capsule, step is as follows:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, remove coarse toilet paper, be ground into fine powder;

(3) by the grinding of Rhizoma Zingiberis Recens Fructus Gardeniae, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 4 times amount 35%, percolation, collect percolate, leave standstill 8 hours, filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 50 minutes, add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, each 40 minutes, merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into the thick paste of relative density 1.20, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 1-2 grain, every day 3 times, 5 days courses for the treatment of.

test example:in order to verify the curative effect of gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus medicament (embodiment 4), we have done contrast test between in May ,-2011 in February, 2009.

General data: the patient screening 250 routine calculus of bile duct in Duo Suo hospital, the shortest person of the course of disease about 1 month, most elder reaches 16 years, average 8.6 years; Minimal ages 18 years old, max age 67 years old, 49 years old mean age; Female patient 168 people, male patient 82 people.Be divided into experimental group and matched group Liang Ge group (wherein, experimental group 150 people, matched group 100 people) at random.

Diagnostic criteria: the diagnostic criteria with reference to calculus of bile duct in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":

1, leukocyte raises, and shift to left, determination of bilirubin prompts for obstructive jaundice.

2, calculus is had in ultrasound diagnosis bile duct.

3, the many Nonvisualizations of oral cholecystography, PTC, ERCP check and see Intrahepatic Bile Duct Dilation, obstruction of bile duct etc.

4, CT examination has gallbladder to expand or calculus existence.

Usage and dosage: experimental group takes gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus drug capsule, each 2, every day 3 times, 5 days courses for the treatment of.Matched group: adopt other treatment mode (as cholagogic and lithagogue tablet, fufangdantong capsules etc.), cholagogic and lithagogue tablet 6-10 sheet, 2 times on the one; Fufangdantong capsules one time 2,3 times on the one.

Curative effect situation criterion: with reference to calculus of bile duct efficacy assessment standard in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":

(1) cure: B ultrasonic etc. check without calculus, clinical symptom disappearance.

(2) effective: symptom takes a turn for the better, but still residual calculus person.

(3) invalid: the symptoms such as pain, cold and heat, jaundice do not disappear, and still have calculus.

3 courses for the treatment of of medication treatment, observe latter 1 month for the treatment of, and follow up a case by regular visits to and observe with or without recurrence for 1 year.The Comparison of therapeutic of the matched group taking other drug and the experimental group taking gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus medicament, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, the inefficiency taking gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus medicament is only 2.67%, and take other drug have 16% inefficiency, and take the cure rate of gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus medicament up to 66.67%, and the cure rate taking other drug only reaches 43%.Experiment shows that the curative effect of gained liver gallbladder damp-heat type calculus of bile duct of the present invention removing toxic substances calculus medicament is more remarkable, and cure rate is high, and inefficiency is low.Be treat the more desirable medicament of calculus of bile duct at present, and this medicament adopt Chinese herbal medicine to make, and not containing any hormone, has no side effect to human body.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Gentianae 15-30 part; Endothelium Corneum Gigeriae Galli 10-20 part; Rhizoma Zingiberis Recens Fructus Gardeniae 8-16 part; Radix Astragali 20-30 part; Herba Centipedae 8-16 part; Fructus Toosendan 8-12 part; Herba Scutellariae Barbatae 7-14 part; Os Sepiae 9-13 part; Herba Salviae Chinensis 6-9 part; Aralia decaisneana Hance 5-9 part; Herba Hedyotidis Diffusae 5-10 part; Herb Gynostemmae Pentaphylli 7-12 part; Sal Nitri 9-15 part; Cortex Ilicis Rotundae 3-6 part; Herba violae patrinii 4-9 part; Radix Glycyrrhizae 8-12 part.

2. liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Gentianae 20-25 part; Endothelium Corneum Gigeriae Galli 13-17 part; Rhizoma Zingiberis Recens Fructus Gardeniae 11-13 part; Radix Astragali 23-27 part; Herba Centipedae 11-13 part; Fructus Toosendan 9-11 part; Herba Scutellariae Barbatae 9-12 part; Os Sepiae 10-12 part; Herba Salviae Chinensis 7-8 part; Aralia decaisneana Hance 6-8 part; Herba Hedyotidis Diffusae 6-9 part; Herb Gynostemmae Pentaphylli 8-11 part; Sal Nitri 11-13 part; Cortex Ilicis Rotundae 4-5 part; Herba violae patrinii 5-8 part; Radix Glycyrrhizae 9-11 part.

3. liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Gentianae 22 parts; Endothelium Corneum Gigeriae Galli 15 parts; Rhizoma Zingiberis Recens Fructus Gardeniae 12 parts; The Radix Astragali 25 parts; Herba Centipedae 12 parts; Fructus Toosendan 10 parts; Herba Scutellariae Barbatae 11 parts; Os Sepiae 11 parts; Herba Salviae Chinensis 7.5 parts; Aralia decaisneana Hance 7 parts; Herba Hedyotidis Diffusae 7 parts; Herb Gynostemmae Pentaphylli 9 parts; Sal Nitri 12 parts; Cortex Ilicis Rotundae 4.5 parts; Herba violae patrinii 6 parts; 10 parts, Radix Glycyrrhizae.

4., according to claim 1-3 arbitrary described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, high temperature sterilization 20-40 minute, sterile packaged.

5. the preparation method of liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament according to claim 4, is characterized in that: step (5) is preferred, and high temperature sterilization 25-35 minute, is more preferably, high temperature sterilization 30 minutes.

6., according to claim 1-3 arbitrary described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) by step (3) and step (4) gained liquid mixing even, be concentrated into relative density 1.20-1.40(preferred, be concentrated into relative density 1.25-1.35, be more preferably, be concentrated into relative density 1.30), add starch, mix homogeneously, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, encapsulate with the specification of every parcel 6g.

7. the preparation method of liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament according to claim 6, it is characterized in that: step (5) is preferred, the consumption of starch is the 10%-20% of medicated powder gross mass, is more preferably, and the consumption of starch is 15% of medicated powder gross mass.

8., according to claim 1-3 arbitrary described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.20-1.40, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

9. the preparation method of liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament according to claim 8, is characterized in that: step (5) is preferred, is concentrated into relative density 1.25-1.35, is more preferably, be concentrated into relative density 1.30.

10., according to claim 1-3 arbitrary described liver gallbladder damp-heat type calculus of bile duct removing toxic substances calculus medicament, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is:

(1) sand is put into pot to make popular, add clean Endothelium Corneum Gigeriae Galli, slow fire stirs to brown color or coke yellow, takes out, and sieve shakeout, is ground into fine powder;

(2) by Radix Gentianae, the Radix Astragali and Aralia decaisneana Hance section (preferred, slice thickness is 3-5mm, is more preferably, and slice thickness is 4mm), mix homogeneously, wraps up three layers with coarse toilet paper by medicine, puts into water and drenches, and puts in pot interior-heat sand and simmers to sallow, cooling, removes coarse toilet paper, is ground into fine powder;

(3) Rhizoma Zingiberis Recens Fructus Gardeniae is ground, be placed in glass container, add step (1)-(2) gained fine powder, mix homogeneously, add the alcohol dipping of 3-5 times amount 30%-40%, percolation, collect percolate, it is (preferred to leave standstill 6-10 hour, leave standstill 7-9 hour, be more preferably, leave standstill 8 hours), filter, reclaim ethanol extremely without alcohol taste;

(4) Os Sepiae and Sal Nitri are smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add Herba Centipedae, Fructus Toosendan, Herba Scutellariae Barbatae, Herba Salviae Chinensis, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, Cortex Ilicis Rotundae, Herba violae patrinii and Radix Glycyrrhizae, decoct twice, within each 30-50 minute, (preferred, each 35-45 minute, is more preferably, each 40 minutes), merge twice decocting liquid;

(5) step (3) and step (4) gained liquid mixing is even, be concentrated into relative density 1.10-1.30 thick paste (preferred, be concentrated into the thick paste of relative density 1.15-1.25, be more preferably, be concentrated into the thick paste of relative density 1.20), dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.