CN104147573A - Heat clearing and toxin removing preparation for treating wind-induced headache - Google Patents
Heat clearing and toxin removing preparation for treating wind-induced headache Download PDFInfo
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Abstract
The invention discloses a heat clearing and toxin removing preparation for treating wind-induced headache. The preparation is prepared from following raw material medicines, by weight, 3-9 parts of mix-fried radix glycyrrhizae, 3-6 parts of pigeon pea roots, 2-6 parts of fresh ginger, 6-12 parts of date, 5-15 parts of folium perillae, 3-12 parts of platycodon grandiflorum, 9-16 parts of peucedanum praeruptorum, 9-13 parts of fructus arctii, 6-12 parts of nepeta cataria panicles, 4-9 parts of fructus viticis, 6-15 parts of notopterygium, 4-14 parts of divaricate saposhnikovia roots, 3-8 parts of solidago decurrens, 6-15 parts of xanthium sibiricum, 5-14 parts of forsythia suspensa, 12-20 parts of isatis tinctoria, 5-12 parts of bupleurum, 3-9 parts of radix scutellariae, 6-18 parts of pueraria lobata roots and 4-9 parts of commelina hengalensis. The preparation has effects of clearing heat and removing toxin, and freeing orifices and relieving pain, and has a good curative effect on wind-induced headache without toxic and side effects.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to Chinese medicine preparation of a kind of heat-clearing and toxic substances removing for the treatment of wind sense headache and preparation method thereof.
Background technology
Headache is one of clinical common sympton, conventionally will be confined to the head first half, comprises the pain general designation headache with upper part of geisoma, helix upper limb and the outer knuckle line of pillow.The reason that causes headache is varied, and neuralgia, intracranial infection, intracranial space-occupying lesion, cerebrovascular disease, cranium the outside maxillofacial disease and general disease all can cause headache as actute infection, poisoning etc.Headache mode of onset can be divided into: the 1. headache of Acute onset; 2. the headache of subacute onset; 3. the headache of chronic onset.Age of onset is common in youth, middle age and old.Headache is divided into headache due to invasion of exogenous pathogens, the large type of headache due to internal injury two by motherland's medical literature.Wind sense headache is exactly a class of headache due to invasion of exogenous pathogens, and headache due to pathogenic wind-heat is a kind of common disease in headache, and Chinese medical discrimination thinks, thus wind heat belong to sun, on disturb key headache clearly as split, scorching on pathogenic fire, therefore flushed face with red ears; Wind heat is at table, therefore fever and aversion to wind; Heat is impairment of body fluid very, therefore thirsty as drink.The general formulas that adopt the evanescence of heat heresy of dispelling in clinical treatment more.Headche due to wind-cold, Chinese medical discrimination is thought, headche due to wind-cold is because of affection by exopathogenic cold-wind, follow through upper criminal mountain peak and push up, clear sun is held back, unable heresy of dredging internal organs that its exopathogen is invaded is cold, thus its passages through which vital energy circulates circulation person's back, upper to top, mountain peak, pathogen attack outward, through gas do not relax that headache connects and person's back, wind and cold bundle table, defensive QI being obstructed, therefore aversion to wind and cold, traditional treatment is mainly with the eliminating evil square medicine except trembling with fear.
At present, the medicine for the treatment of headache is both at home and abroad a lot, and all can only symptomatic treatment, pain relieving is main, cures the symptoms, not the disease, and patient's headache outbreak repeatedly, its long-term taking pain relieving class medicine can produce drug resistance and addiction, therefore the unsuitable long-term taking of such medicine can not fundamentally solve the puzzlement of headache.In addition, also use antianxiety drug, resist melancholy agent, sympathetic inhibitor, calcium channel blocker, antiepileptic etc. according to the different causes of disease clinically, these side effects of pharmaceutical drugs are larger, long-term taking can make curative effect reduce gradually, so that patient's dosage of having to increase gradually, result is taken medicine more, has a headache but serious all the more.At present, Chinese medicine has good effect on to the treatment of headache, can reach treating both the principal and secondary aspects of a disease, the absolute advantages that side effect is little, but onset is its major defect more slowly, this has affected patient's quality of life.For this reason, have to be excavated, promote new Chinese medicine formula, for treatment wind sense headache provides through practice test, the Chinese medicine of the treatment wind sense headache that proving effect is good.
Publication number CN 103893572A(application number 201410093416.2) Chinese patent literature a kind of pharmaceutical composition for the treatment of headache is disclosed, said composition by Rhizoma Gastrodiae, Radix Angelicae Sinensis, Scorpio, Radix Saposhnikoviae, Radix Rehmanniae, Flos Carthami,
Rhizoma Chuanxiong and Radix Salviae Miltiorrhizae are made.Publication number CN 103877241A(application number 201310727054.3) Chinese patent literature a kind of medicine for the treatment of headache is disclosed, this medicine is made up of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Semen Cassiae, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Concha Margaritifera and Herba Asari.Publication number CN 103417765A(application number 201310338155.1) Chinese patent literature a kind of medicine for the treatment of headche due to wind-cold is disclosed, wherein the ratio of weight and number of each component is: Radix Angelicae Dahuricae 8-12 part, Radix Bupleuri 6-13 part, Radix Saposhnikoviae 12-18 part, Herba Schizonepetae 8-15 part, Ramulus Cinnamomi 6-12 part, Radix Angelicae Sinensis 8-12 part, Herba Asari 4-6 part, Rhizoma Chuanxiong 7-12 part, Rhizoma Atractylodis 8-12 part, Concha Ostreae 10-15 part, Rhizoma Acori Graminei 10-16 part, Radix Glycyrrhizae 8-12 part.
In a word, in Chinese medicine, the prescription for the treatment of headache is more, therapeutic effect is had nothing in common with each other, and has hindered its applying clinically.The medicine of existing treatment headache is main mainly with temporary transient treatment, more easily recurrence, and curative effect is undesirable, and therefore, the traditional Chinese medical science is to be further improved in addition to the treatment research of wind sense headache.
Summary of the invention
For making up the deficiencies in the prior art, the object of this invention is to provide one has heat-clearing and toxic substances removing to cat fever patient, understand things pain-stopping effect, the antipyretic-detoxicant preparation and the preparation method that have the treatment wind sense of good result to have a headache for wind sense headache.This Chinese medicine preparation determined curative effect and having no side effect.
Technical scheme of the present invention is:
Chinese medicine preparation and the preparation method of the heat-clearing and toxic substances removing for the treatment of wind sense headache, the main raw material(s) that takes off row weight proportion is prepared from: Radix Glycyrrhizae Preparata 3-9; Semen Cajani root 3-6; Rhizoma Zingiberis Recens 2-6; Fructus Jujubae 6-12; Folium Perillae 5-15; Radix Platycodonis 3-12; Radix Peucedani 9-16; Fructus Arctii 9-13; Herba Schizonepetae 6-12; Fructus Viticis 4-9; Rhizoma Et Radix Notopterygii 6-15; Radix Saposhnikoviae 4-14; Herba Solidaginis 3-8; Fructus Xanthii 6-15; Fructus Forsythiae 5-14; Radix Isatidis 12-20(is preferred, Radix Isatidis 14-18; Be more preferably Radix Isatidis 16); Radix Bupleuri 5-12; Radix Scutellariae 3-9; Radix Puerariae 6-18; Horse Auricled Hedyotis Herb 4-9.
In preferred version, Radix Glycyrrhizae Preparata 4-8; Semen Cajani root 4-5; Rhizoma Zingiberis Recens 3-5; Fructus Jujubae 8-10; Folium Perillae 8-12; Radix Platycodonis 5-10; Radix Peucedani 10-15; Fructus Arctii 10-12; Herba Schizonepetae 7-11; Fructus Viticis 5-8; Rhizoma Et Radix Notopterygii 8-13; Radix Saposhnikoviae 6-12; Herba Solidaginis 4-7; Fructus Xanthii 8-13; Fructus Forsythiae 7-12; Radix Isatidis 15-17; Radix Bupleuri 7-10; Radix Scutellariae 5-7; Radix Puerariae 8-16; Horse Auricled Hedyotis Herb 5-8.Preferred scheme is, Radix Glycyrrhizae Preparata 6; Semen Cajani root 4.5; Rhizoma Zingiberis Recens 4; Fructus Jujubae 9; Folium Perillae 10; Radix Platycodonis 7.5; Radix Peucedani 12.5; Fructus Arctii 11; Herba Schizonepetae 9; Fructus Viticis 6.5; Rhizoma Et Radix Notopterygii 10.5; Radix Saposhnikoviae 9; Herba Solidaginis 5.5; Fructus Xanthii 10.5; Fructus Forsythiae 9.5; Radix Isatidis 16; Radix Bupleuri 8.5; Radix Scutellariae 6; Radix Puerariae 12; Horse Auricled Hedyotis Herb 6.5.
The present invention also provides the method for aforementioned Chinese medicine preparation being made to pharmaceutically acceptable decoction, tablet and pill.
The preparation process of described decoction is as follows:
(1) Rhizoma Zingiberis Recens is smashed to pieces, filtered through gauze, obtains Rhizoma Zingiberis Recens juice;
(2) Radix Bupleuri of proportional quantity and Radix Saposhnikoviae powder are broken into coarse granule, use 80% ethanol, 80 DEG C of reflux, extract, 3 times, each 1-2 hour (preferably 1.5 hours), filter to get filtrate, merge three times extracting solution, filtrate is at vacuum 50-60 DEG C, be concentrated into relative density 1.32(60-70 DEG C), obtain extracting solution I for subsequent use;
(3) Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, soak 30-50 minute (preferably 40 minutes) then intense fire be fried open, put into Folium Perillae, Herba Schizonepetae, Radix Glycyrrhizae Preparata, Herba Solidaginis, horse Auricled Hedyotis Herb, after being fried open, turn 40-50 at a simmer minute (preferably 45 minutes), filter to obtain medicinal liquid, stay recrement;
(4) recrement is watered intense fire and is fried open, and turns 1-2 at a simmer hour after (preferably 1.5 hours) and leaches medicinal liquid;
(5) recrement is watered to intense fire again and boils, turn 1.5-2.5 at a simmer hour after (preferably 2 hours), leach medicinal liquid, by three medicinal liquid mix homogeneously and be concentrated into relative density 1.34(55-65 DEG C), obtain extracting solution II;
(6) Rhizoma Zingiberis Recens juice and extracting solution I, extracting solution II are mixed, sterile packaged, obtains Chinese medicine composition decoction.
The preparation method of described Chinese medicine decoction, in step (1), the consumption of 80% ethanol is doubly (preferably 10 times) of 8-12 of medical material weight.
The preparation method of described Chinese medicine decoction, step (3) is that Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, the water surface exceeds 3 centimetres of medical materials.
The preparation method of described tablet is: each crude drug was pulverized to 60-80 mesh sieve (preferably 70 mesh sieves), mix each medicated powder, obtain Chinese medicine composition medicinal powder, Chinese medicine composition medicinal powder, according to 0.2-0.3g/ sheet (preferably 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
The preparation method of described pill is: by step (6) gained Chinese medicine composition decoction, and vacuum drying, dried cream powder is broken, obtains dry thing.To be dried thing according to 0.3-0.4g/ (preferably 0.35g/) metering, be processed into ball shape dosage form according to the preparation for processing of pill.
The application of heat-clearing and detoxifying herb compositions described in the present invention also provides in the time of the medicine of preparation treatment wind sense headache.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Glycyrrhizae Preparata: Radix Glycyrrhizae: be dry root and the rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and remove fibrous root, dry.Radix Glycyrrhizae Preparata: extracting liquorice sheet, fry to yellow to buff according to processed with honey method, when tack-free, take out, dry in the air cool.Nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Semen Cajani root: base is former: be the root of pulse family Semen Cajani platymiscium Semen Cajani.Nature and flavor: hardship, cold.Effect: heat-clearing and toxic substances removing, dampness removing, hemostasis.Cure mainly: for laryngopharynx swelling and pain, ulcer sore pain, bleeding hemorrhoids, stranguria with blood, edema, dysuria.
Rhizoma Zingiberis Recens: nature and flavor: sweet, flat.Gui Jing: return stomach, the heart, lung, spleen channel.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Fructus Jujubae: nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach, heart channel.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Cure mainly: for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Folium Perillae: nature and flavor: pungent, temperature.Gui Jing: return lung, spleen channel.Effect: the cold expelling that induces sweat, relieving QI stagnancy in the stomach.Cure mainly: for anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
Radix Platycodonis: nature and flavor: bitter, pungent, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
Radix Peucedani: nature and flavor: bitter, pungent, be slightly cold.Gui Jing: return lung meridian.Effect: lowering the adverse-rising QI to resolve phlegm, loose wind heat clearing away.Cure mainly: full for expectorant dyspnea of heat type, cough up phlegm yellow thick. cough due to pathogenic wind-heat's abundant expectoration.
Fructus Arctii: nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Effect: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.Cure mainly: for anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps, erysipelas, carbuncle sore tumefacting virus.
Herba Schizonepetae: nature and flavor: pungent, tepor.Gui Jing: return lung, Liver Channel.Effect: the loose wind that induces sweat, rash, skin ulcer disappears.Cure mainly: for flu, headache, measles, rubella, skin infection from the beginning of.
Fructus Viticis: nature and flavor: pungent, bitter, be slightly cold.Gui Jing: return bladder, liver, stomach warp.Effect: dispelling wind and heat pathogens, the clear sharp head.Cure mainly: for anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
Rhizoma Et Radix Notopterygii: nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Effect: the cold expelling that induces sweat, expelling wind and removing dampness, pain relieving.Cure mainly: for anemofrigid cold, headache stiffness of the nape, rheumatic arthralgia, aching pain in should and back.
Radix Saposhnikoviae: nature and flavor: pungent, sweet, tepor.Gui Jing: return bladder, liver, spleen channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly: for headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Herba Solidaginis: base is former: be herb or the root of Compositae Herba Solidaginis platymiscium Herba Solidaginis.Composition: aerial parts contains saponin component: Herba Solidaginis glycosides, activities of Solidago virgaurea L saponin 3 is 3, Solidago saponin, solidago canadesis saponin, huge Herba Solidaginis saponin, the triterpene glycosides of Polygalacic acid etc.Nature and flavor: pungent, bitter, cool.Effect: wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Cure mainly: anemopyretic cold, laryngopharynx swelling and pain, cough due to lung-heat, jaundice, pyretic stranguria, carbuncle furuncle, venom, traumatic injury.Compatibility and incompatibility of drugs: " Guangdong Chinese medicine ": " can not decoct for a long time, decoct for a long time nauseating.”
Fructus Xanthii: nature and flavor: pungent, bitter, temperature; Poisonous.Gui Jing: return lung meridian.Effect: dispersing wind and cold, clearing the nasal passage, wind-damp dispelling.Cure mainly: for headche due to wind-cold, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.Fructus Forsythiae: nature and flavor: hardship, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly: for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm people battalion, high hot excessive thirst, coma is sent out speckle, the puckery pain of pyretic stranguria.
Radix Isatidis: hardship, cold.Gui Jing: GUIXIN, stomach warp.Effect: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Cure mainly: for pestilence seasonal noxious pathogen, heating pharyngalgia, maculae caused by violent heat pathogen, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle.
Radix Bupleuri: nature and flavor: pungent, bitter, be slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Effect: evacuate and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Radix Scutellariae: nature and flavor: hardship, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Cure mainly: for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Puerariae: nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach, lung meridian.Effect: expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.Cure mainly: for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
Horse Auricled Hedyotis Herb: base is former: be the herb of Commeline communis section Commeline communis platymiscium meal bag grass.Composition: herb contains n-Octacosanol, myricyl alcohol, positive laccerol, stigmasterol ,-sitosterol, campesterol and benzyladenine etc.The property of medicine: hardship, cold.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly calentura heating, excessive thirst, laryngopharynx swelling and pain, hematodiarrhoea, pyretic stranguria, hemorrhoid, furuncle carbuncle, snake bite and insect sting.
Wind sense provided by the invention headache antipyretic-detoxicant preparation prescription science, the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention have easy to make, use safely, have no side effect;
2, positive pain management wind sense headache is got rid of evils, held under the arm to this prescription with expelling wind and clearing away heat, thin muscle, has effect for the treatment of both the principal and secondary aspects of a disease.
3, this prescription meets the feature of Chinese medicine principle and wind sense headache completely, under the prerequisite of general principle, can do suitable adjustment according to crowd's difference, has motility.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is prepared from by following bulk drugs: Radix Glycyrrhizae Preparata 3g, Semen Cajani root 3g, Rhizoma Zingiberis Recens 2g, Fructus Jujubae 6g, Folium Perillae 5g, Radix Platycodonis 3g, Radix Peucedani 9g, Fructus Arctii 9g, Herba Schizonepetae 6g, Fructus Viticis 4g, Rhizoma Et Radix Notopterygii 6g, Radix Saposhnikoviae 4g, Herba Solidaginis 3g, Fructus Xanthii 6g, Fructus Forsythiae 5g, Radix Isatidis 12g, Radix Bupleuri 5g, Radix Scutellariae 3g, Radix Puerariae 6g, horse Auricled Hedyotis Herb 4g.The preparation method of the heat-clearing and detoxifying herb water preparation of above-mentioned treatment wind sense headache is:
(1) Rhizoma Zingiberis Recens is smashed to pieces, filtered through gauze, obtains Rhizoma Zingiberis Recens juice;
(2) Radix Bupleuri of proportional quantity and Radix Saposhnikoviae powder are broken into coarse granule, with 80% ethanol of 8 times of medical material weight, 80 DEG C of reflux, extract, 3 times, each 1 hour, filter to get filtrate, merge three times extracting solution, filtrate, at vacuum 50-60 DEG C, is concentrated into relative density 1.32(60-70 DEG C), obtain extracting solution I for subsequent use;
(3) Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, add water, the water surface exceeds 3 centimetres of medical materials.Soak 30 minutes, then intense fire is fried open, and puts into Folium Perillae, Herba Schizonepetae, Radix Glycyrrhizae Preparata, Herba Solidaginis, horse Auricled Hedyotis Herb, turns 40 minutes at a simmer after being fried open, and filters to obtain medicinal liquid, stays recrement;
(4) recrement is watered intense fire and is fried open, and leaches medicinal liquid after turning 1 hour at a simmer;
(5) recrement is watered to intense fire again and boils, turn after 1.5 hours at a simmer, leach medicinal liquid, by three medicinal liquid mix homogeneously and be concentrated into relative density 1.34(55-65 DEG C), obtain extracting solution II;
(6) Rhizoma Zingiberis Recens juice and extracting solution I, extracting solution II are mixed, sterile packaged, obtains Chinese medicine composition decoction.
The instructions of taking of decoction of the present invention: decoction is 5 days courses for the treatment of, takes 2 times (warm) every day, each 200m1-300m1.
Model case: xxx, female, 34 years old, first visit headache due to invasion of exogenous pathogens ten days, patient, over nearly 3 years, has a headache after each flu, taking analgesic can alleviate temporarily, but have a headache and do again after flu, nearly ten days next time, after flu, cold symptoms disappears to have a headache and does again, existing disease, whole body distending pain, especially taking both sides temple as main, head is scorching hot, red tongue with yellow fur.Be diagnosed as wind sense headache.
Take the heat-clearing and detoxifying herb compositions decoction of the present embodiment gained treatment wind sense headache, each 300ml, twice of every day (warm), 5 days courses for the treatment of.Take after 3 days, headache is alleviated, and whole body distending pain alleviates, continue to take 3 days, and headache, the malaise symptoms such as distending pain disappear, and patient's recovery from illness, has no recurrence.
embodiment 2the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is prepared from by following bulk drugs: Radix Glycyrrhizae Preparata 9g, Semen Cajani root 6g, Rhizoma Zingiberis Recens 6g, Fructus Jujubae 12g, Folium Perillae 15g, Radix Platycodonis 12g, Radix Peucedani 16g, Fructus Arctii 13g, Herba Schizonepetae 12g, Fructus Viticis 9g, Rhizoma Et Radix Notopterygii 15g, Radix Saposhnikoviae 14g, Herba Solidaginis 8g, Fructus Xanthii 15g, Fructus Forsythiae 14g, Radix Isatidis 20g, Radix Bupleuri 12g, Radix Scutellariae 9g, Radix Puerariae 18g, horse Auricled Hedyotis Herb 9g.The preparation method of the heat-clearing and detoxifying herb tablet for the treatment of wind sense headache is: each crude drug was pulverized to 60 mesh sieves, mix each medicated powder, obtain Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder, according to the metering of 0.2g/ sheet, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.Tablet adopts every day twice, each 3-4 sheet, and with warm boiled water, 5 days courses for the treatment of.
Model case: xxx, female, 21 years old.Catch a cold because of wind at night, the temple jumping pain of waking up morning, had a headache after 2 days, aggravation, and nausea and vomiting when headache is heavy, vexed, red tongue yellow fur, sublingual vein anger is opened, dizzy drowsiness, weak.Take NAOQING sheet, the analgesic such as ibuprofen can be alleviated temporarily.Be diagnosed as wind sense headache.
Take the heat-clearing and detoxifying herb composition tablet of the present embodiment gained treatment wind sense headache, every day twice, each 4, warm boiled water, 5 days courses for the treatment of.Take after 2 days, headache alleviates, and temple jumping pain disappears, and nausea and vomiting, is vexedly also eased.Continue to take 3 days, headache, the malaise symptoms such as drowsiness disappear completely, and the recovery from illness of patient's self-induction, has no recurrence.
embodiment 3the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is prepared from by following bulk drugs: Radix Glycyrrhizae Preparata 4g, Semen Cajani root 4g, Rhizoma Zingiberis Recens 3g, Fructus Jujubae 8g, Folium Perillae 8g, Radix Platycodonis 5g, Radix Peucedani 10g, Fructus Arctii 10g, Herba Schizonepetae 7g, Fructus Viticis 5g, Rhizoma Et Radix Notopterygii 8g, Radix Saposhnikoviae 6g, Herba Solidaginis 4g, Fructus Xanthii 8g, Fructus Forsythiae 7g, Radix Isatidis 15g, Radix Bupleuri 7g, Radix Scutellariae 5-7, Radix Puerariae 8g, horse Auricled Hedyotis Herb 5g.The preparation method of the heat-clearing and detoxifying herb pill for the treatment of wind sense headache is:
(1) Rhizoma Zingiberis Recens is smashed to pieces, filtered through gauze, obtains Rhizoma Zingiberis Recens juice;
(2) Radix Bupleuri of proportional quantity and Radix Saposhnikoviae powder are broken into coarse granule, with 80% ethanol of 12 times of medical material weight, 80 DEG C of reflux, extract, 3 times, each 2 hours, filter to get filtrate, merge three times extracting solution, filtrate is at vacuum 50-60 DEG C, be concentrated into relative density 1.32(60-70 DEG C), obtain extracting solution I for subsequent use;
(3) Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, add water, the water surface exceeds 3 centimetres of medical materials.Soak 50 minutes, then intense fire is fried open, and puts into Folium Perillae, Herba Schizonepetae, Radix Glycyrrhizae Preparata, Herba Solidaginis, horse Auricled Hedyotis Herb, turns 50 minutes at a simmer after being fried open, and filters to obtain medicinal liquid, stays recrement;
(4) recrement is watered intense fire and is fried open, and leaches medicinal liquid after turning 2 hours at a simmer;
(5) recrement is watered to intense fire again and boils, turn after 2.5 hours at a simmer, leach medicinal liquid, by three medicinal liquid mix homogeneously and be concentrated into relative density 1.34(55-65 DEG C), obtain extracting solution II;
(6) Rhizoma Zingiberis Recens juice and extracting solution I, extracting solution II are mixed, sterile packaged, obtains Chinese medicine composition decoction.
(7) by step (6) gained Chinese medicine composition decoction, vacuum drying, dried cream powder is broken, obtains dry thing.To be dried thing according to 0.35g/ metering, be processed into ball shape dosage form according to the preparation for processing of pill.
Pill adopts every day twice, each 2-3, and with warm boiled water, 5 days courses for the treatment of.
Model case: xxx, man, 40 years old.Because of the regular headache that flu causes, bilateral temple distending pain, with nausea and vomiting, red tip of the tongue yellow fur, wiry and frequent pulse, dizzy drowsiness when pain, face has the sense of rising.Take the god of unit peace granule, symptom is slightly alleviated, but recurrence again behind this month.Be diagnosed as wind sense headache.
Take the heat-clearing and detoxifying herb compositions pill of the present embodiment gained treatment wind sense headache, every day twice, each 2, warm boiled water, 5 days courses for the treatment of.Take after 3 days, headache alleviates, and temple distending pain alleviates, and nausea and vomiting is also eased.Continue to take 4 days, headache, the dizzy malaise symptoms such as drowsiness disappear completely, the recovery from illness of patient's self-induction, and drug withdrawal has no recurrence for three months.
embodiment 4the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is prepared from by following bulk drugs: Radix Glycyrrhizae Preparata 8g, Semen Cajani root 5g, Rhizoma Zingiberis Recens 5g, Fructus Jujubae 10g, Folium Perillae 12g, Radix Platycodonis 10g, Radix Peucedani 15g, Fructus Arctii 12g, Herba Schizonepetae 11g, Fructus Viticis 8g, Rhizoma Et Radix Notopterygii 13g, Radix Saposhnikoviae 12g, Herba Solidaginis 7g, Fructus Xanthii 13g, Fructus Forsythiae 12g, Radix Isatidis 17g, Radix Bupleuri 10g, Radix Scutellariae 7g, Radix Puerariae 16g, horse Auricled Hedyotis Herb 8g.The preparation method of the heat-clearing and detoxifying herb tablet for the treatment of wind sense headache is: each crude drug was pulverized to 70 mesh sieves, mix each medicated powder, obtain Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder, according to the metering of 0.25g/ sheet, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.Tablet adopts every day twice, each 3-4 sheet, and with warm boiled water, 5 days courses for the treatment of.
embodiment 5the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is prepared from by following bulk drugs: Radix Glycyrrhizae Preparata 6g, Semen Cajani root 4.5g, Rhizoma Zingiberis Recens 4g, Fructus Jujubae 9g, Folium Perillae 10g, Radix Platycodonis 7.5g, Radix Peucedani 12.5g, Fructus Arctii 11g, Herba Schizonepetae 9g, Fructus Viticis 6.5g, Rhizoma Et Radix Notopterygii 10.5g, Radix Saposhnikoviae 9g, Herba Solidaginis 5.5g, Fructus Xanthii 10.5g, Fructus Forsythiae 9.5g, Radix Isatidis 16g, Radix Bupleuri 8.5g, Radix Scutellariae 6g, Radix Puerariae 12g, horse Auricled Hedyotis Herb 6.5g.The preparation method of the heat-clearing and detoxifying herb water preparation for the treatment of wind sense headache:
(1) Rhizoma Zingiberis Recens is smashed to pieces, filtered through gauze, obtains Rhizoma Zingiberis Recens juice;
(2) Radix Bupleuri of proportional quantity and Radix Saposhnikoviae powder are broken into coarse granule, with 80% ethanol of 10 times of weight of medical material, 80 DEG C of reflux, extract, 3 times, each 1.5 hours, filter to get filtrate, merge three times extracting solution, filtrate is at vacuum 50-60 DEG C, be concentrated into relative density 1.32(60-70 DEG C), obtain extracting solution I for subsequent use;
(3) Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, add water, the water surface exceeds 3 centimetres of medical materials.Soak 40 minutes, then intense fire is fried open, and puts into Folium Perillae, Herba Schizonepetae, Radix Glycyrrhizae Preparata, Herba Solidaginis, horse Auricled Hedyotis Herb, turns 45 minutes at a simmer after being fried open, and filters to obtain medicinal liquid, stays recrement;
(4) recrement is watered intense fire and is fried open, and leaches medicinal liquid after turning 1.5 hours at a simmer;
(5) recrement is watered to intense fire again and boils, turn after 2 hours at a simmer, leach medicinal liquid, by three medicinal liquid mix homogeneously and be concentrated into relative density 1.34(55-65 DEG C), obtain extracting solution II;
(6) Rhizoma Zingiberis Recens juice and extracting solution I, extracting solution II are mixed, sterile packaged, obtains Chinese medicine composition decoction.
test example 1the clinical practice of the heat-clearing and detoxifying herb compositions decoction of embodiment 5 gained treatment wind sense headaches: in March, 2010-2012 year December, screen 158 routine patients in 5 hospitals, be divided at random two groups.Treatment group 114 examples, wherein women's 69 examples, male's 45 examples, man: female=1:1.5, the oldest 64 years old, minimum 18 years old, 40.3 years old mean age; Matched group 44 examples, wherein women and male are 22 examples, man: female=1:1, the oldest 67 years old, minimum 14 years old, 39.3 years old mean age.Treatment group is taken embodiment 5 products obtained therefroms, and using method is: take every day twice (warm), each 200m1-300m1(adjusts to some extent depending on conditions of patients), 5 days courses for the treatment of; Matched group is taken other medicine (carbamazepine, oral Nimoldipine, the god of unit pacify the conventional medicines such as granule, ZHENNAONING JIAONANG).
Curative effect determinate standard: cure: take this product headache and disappear, energy and muscle power obviously strengthen, after drug withdrawal in three months without recurrence; Effective: take this product headache and obviously alleviate, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen, even after drug withdrawal have recurrence, but pain is light, and number of times is few, and the persistent period is short; Invalid: take this product, headache malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 4 product 18-64 year wind sense headache therapeutic outcomes
Therapeutic effect: cure 92 examples (80.7%), effective 18 examples (15.8%), invalid 4 examples (3.5%), total effective rate 96.5%.Successful is better than matched group.
During taking, symptom and change of spirit thereof are as shown in table 2.
Table 2:
The present invention is taking heat-clearing and toxic substances removing as main effect, select Semen Cajani root, Folium Perillae, Radix Peucedani,, Herba Schizonepetae, Fructus Viticis, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Radix Scutellariae, horse Auricled Hedyotis Herb etc. carry out compatibility, make to produce synergism after these drug regimens, can more effectively treat wind sense headache.Semen Cajani root, Fructus Arctii, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and horse Auricled Hedyotis Herb heat-clearing and toxic substances removing in side, removing dampness to relieve pain; Radix Platycodonis, Radix Peucedani and Herba Solidaginis eliminate the phlegm for sore-throat relieving; Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, Radix Puerariae, Fructus Xanthii and Fructus Viticis, for the clear sharp head, are had a dizzy spell; Rhizoma Zingiberis Recens, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind; Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription is played suppressing the hyperactive liver pain relieving altogether, and the effect of heat-clearing and toxic substances removing, therefore can obtain good therapeutic effect.Take 3 days, more than 49% patient feels to take a turn for the better, and headache is alleviated, and malaise symptoms alleviates; Take 6 days, more than 94% patient feels that sb.'s illness took a favorable turn, the rare outbreak of having a headache, and pain number of times and time decreased, malaise symptoms disappears; Take 9 days, more than 97% patient had a headache and remains dormant in three months, the recovery from illness of patient's self-induction.Take more than 9 days, the effective percentage for the treatment of group is 96%, and the effective percentage of matched group is that 83%, two group of therapeutic effect exists significant difference.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. the heat-clearing and detoxifying herb preparation for the treatment of wind sense headache, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Radix Glycyrrhizae Preparata 3-9, Semen Cajani root 3-6, Rhizoma Zingiberis Recens 2-6, Fructus Jujubae 6-12, Folium Perillae 5-15, Radix Platycodonis 3-12, Radix Peucedani 9-16, Fructus Arctii 9-13, Herba Schizonepetae 6-12, Fructus Viticis 4-9, Rhizoma Et Radix Notopterygii 6-15, Radix Saposhnikoviae 4-14, Herba Solidaginis 3-8, Fructus Xanthii 6-15, Fructus Forsythiae 5-14, Radix Isatidis 12-20, Radix Bupleuri 5-12, Radix Scutellariae 3-9, Radix Puerariae 6-18, horse Auricled Hedyotis Herb 4-9.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Radix Glycyrrhizae Preparata 4-8, Semen Cajani root 4-5, Rhizoma Zingiberis Recens 3-5, Fructus Jujubae 8-10, Folium Perillae 8-12, Radix Platycodonis 5-10, Radix Peucedani 10-15, Fructus Arctii 10-12, Herba Schizonepetae 7-11, Fructus Viticis 5-8, Rhizoma Et Radix Notopterygii 8-13, Radix Saposhnikoviae 6-12, Herba Solidaginis 4-7, Fructus Xanthii 8-13, Fructus Forsythiae 7-12, Radix Isatidis 15-17, Radix Bupleuri 7-10, Radix Scutellariae 5-7, Radix Puerariae 8-16, horse Auricled Hedyotis Herb 5-8.
3. Chinese medicine preparation as claimed in claim 1, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Radix Glycyrrhizae Preparata 6, Semen Cajani root 4.5, Rhizoma Zingiberis Recens 4, Fructus Jujubae 9, Folium Perillae 10, Radix Platycodonis 7.5, Radix Peucedani 12.5, Fructus Arctii 11, Herba Schizonepetae 9, Fructus Viticis 6.5, Rhizoma Et Radix Notopterygii 10.5, Radix Saposhnikoviae 9, Herba Solidaginis 5.5, Fructus Xanthii 10.5, Fructus Forsythiae 9.5, Radix Isatidis 16, Radix Bupleuri 8.5, Radix Scutellariae 6, Radix Puerariae 12, horse Auricled Hedyotis Herb 6.5.
4. the Chinese medicine preparation as described in as arbitrary in claim 1-3, is characterized in that, this Chinese medicine preparation is made to pharmaceutically acceptable decoction, tablet and pill.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that, the preparation process of described decoction is as follows:
(1) Rhizoma Zingiberis Recens is smashed to pieces, filtered through gauze, obtains Rhizoma Zingiberis Recens juice;
(2) Radix Bupleuri of proportional quantity and Radix Saposhnikoviae powder are broken into coarse granule, use 80% ethanol, 80 DEG C of reflux, extract, 3 times, each 1-2 hour (preferably 1.5 hours), filter to get filtrate, merge three times extracting solution, filtrate is at vacuum 50-60 DEG C, be concentrated into relative density 1.32(60-70 DEG C), obtain extracting solution I for subsequent use;
(3) Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, soak 30-50 minute (preferably 40 minutes) then intense fire be fried open, put into Folium Perillae, Herba Schizonepetae, Radix Glycyrrhizae Preparata, Herba Solidaginis, horse Auricled Hedyotis Herb, after being fried open, turn 40-50 at a simmer minute (preferably 45 minutes), filter to obtain medicinal liquid, stay recrement;
(4) recrement is watered intense fire and is fried open, and turns 1-2 at a simmer hour after (preferably 1.5 hours) and leaches medicinal liquid;
(5) recrement is watered to intense fire again and boils, turn 1.5-2.5 at a simmer hour after (preferably 2 hours) and leach medicinal liquid, by three medicinal liquid mix homogeneously and be concentrated into relative density 1.34(55-65 DEG C), obtain extracting solution II;
(6) Rhizoma Zingiberis Recens juice and extracting solution I, extracting solution II are mixed, sterile packaged, obtains Chinese medicine composition decoction.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that, described step (2) is that the consumption of 80% ethanol is doubly (preferably 10 times) of 8-12 of medical material weight.
7. Chinese medicine preparation as claimed in claim 5, it is characterized in that, described step (3) is that Semen Cajani root, Fructus Jujubae, Radix Platycodonis, Radix Peucedani, Fructus Arctii, Fructus Viticis, Rhizoma Et Radix Notopterygii, Fructus Xanthii, Fructus Forsythiae, Radix Isatidis, Radix Scutellariae are put into marmite together with Radix Puerariae, and the water surface exceeds 3 centimetres of medical materials.
8. Chinese medicine preparation as claimed in claim 4, it is characterized in that, the preparation method of described tablet is: each crude drug was pulverized to 60-80 mesh sieve (preferably 70 mesh sieves), mix each medicated powder, obtain Chinese medicine composition medicinal powder, Chinese medicine composition medicinal powder, according to 0.2-0.3g/ sheet (preferably 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
9. Chinese medicine preparation as claimed in claim 4, is characterized in that, the preparation method of described pill is: claim 5 step (6) gained Chinese medicine composition decoction, and vacuum drying, dried cream powder is broken, obtains dry thing; To be dried thing according to 0.3-0.4g/ (preferably 0.35g/) metering, be processed into ball shape dosage form according to the preparation for processing of pill.
10. the application of the Chinese medicine preparation as described in as arbitrary in claim 1-3 in the time of preparation treatment sense wind headache.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168659A (en) * | 2015-10-10 | 2015-12-23 | 济南高天机械设备有限公司 | Spray for treating wind-heat invasive type acute suppurative otitis media |
| CN105941318A (en) * | 2016-05-30 | 2016-09-21 | 高启忠 | A low cost raising method for flavor meat pigs |
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| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN103394064A (en) * | 2013-08-08 | 2013-11-20 | 太仓市第一人民医院 | Traditional Chinese medicine composition used for treating slight cold |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN103394064A (en) * | 2013-08-08 | 2013-11-20 | 太仓市第一人民医院 | Traditional Chinese medicine composition used for treating slight cold |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168659A (en) * | 2015-10-10 | 2015-12-23 | 济南高天机械设备有限公司 | Spray for treating wind-heat invasive type acute suppurative otitis media |
| CN105941318A (en) * | 2016-05-30 | 2016-09-21 | 高启忠 | A low cost raising method for flavor meat pigs |
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Address after: 365000 Fujian province Sanming City Fuwen three Yuan District Road No. 1 Fu Wen District 2-2-202 Applicant after: Li Haocheng Address before: 34-1 modern escape city, Jiefang East Road, Lixia District, Ji'nan City, Shandong province 250014 Applicant before: Li Haocheng |
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Application publication date: 20141119 |