CN1872180A - Medication of membranous milk vetch for activating blood and the channels, and preparation method - Google Patents
Medication of membranous milk vetch for activating blood and the channels, and preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating the apoplexy sequelae is prepared from 9 Chinese-medicinal materials including astragalus root, Chinese angelica root, Chuan-xiong rhizome, red peony root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to medicine of a kind of treatment by Chinese herbs apoplexy sequela and preparation method thereof, especially a kind of stilbene blood collateral dredging medicine and preparation method thereof.
Background technology
Apoplexy sequela is commonly encountered diseases, frequently-occurring disease, treats the medicine of apoplexy sequela in the market, generally all has the price height, side effect is arranged, the inapparent defective of curative effect.
Summary of the invention
The objective of the invention is to provide a kind of evident in efficacy, taking convenience, have no side effect, the medicine of moderate treatment apoplexy sequela and preparation method thereof.
The present invention is achieved in that
Stilbene blood collateral dredging medicine, it is by following materials of weight proportions: 40～2000 parts of the Radixs Astragali, 2～100 parts of Radix Angelicae Sinensis, 1～50 part of Rhizoma Chuanxiong, 1.5～75 parts of Radix Paeoniae Rubra, 1～50 part of Pheretima, 1～50 part in Semen Persicae, 1～50 part on Flos Carthami, 1～50 part of Caulis Spatholobi, 4～200 parts of Radix Salviae Miltiorrhizaes, adopt the method for galenic pharmacy to make regular dosage form, comprising: granule, capsule (containing soft capsule), tablet (containing coated tablet, plain sheet, Film coated tablets, chewable tablet, dispersible tablet, effervescent tablet, enteric coatel tablets, fast-release tablet, slow releasing tablet, controlled release tablet), pill (containing honeyed pill, the watered pill, concentrated pill).
Preparation method of the present invention is: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, seven flavor raw materials such as all the other Radixs Astragali directly feed intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65/10～90 ℃ that filtrate is concentrated into relative density, puts cold, add ethanol and make that to contain alcohol amount be 20～90%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, be concentrated into relative density and be 1.10～1.65/10～90 ℃ thick paste, add Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing, make granule, or powder, make granule; Or granule or powder incapsulated, make capsule (containing soft capsule); Or with granule or pressed powder, coating is made tablet (containing coated tablet, plain sheet, Film coated tablets, chewable tablet, dispersible tablet, effervescent tablet, enteric coatel tablets, fast-release tablet, slow releasing tablet, controlled release tablet); Or with granule or powder, compacting or the general pill (containing honeyed pill, the watered pill, concentrated pill) of making.
Granule method for making of the present invention: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, seven flavor raw materials such as all the other Radixs Astragali directly feed intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65 (10～90 ℃) that filtrate is concentrated into relative density, puts cold, add ethanol and make that to contain alcohol amount be 20～90%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.10～1.65 (10～90 ℃), adds Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing, make granule, or powder, make granule.
Tablet method for making of the present invention: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, seven flavor raw materials such as all the other Radixs Astragali directly feed intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65 (10～90 ℃) that filtrate is concentrated into relative density, put cold, adding ethanol, to make the alcohol amount of closing be 20～90%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.10～1.65 (10～90 ℃), add Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing, make granule, or powder, with granule, or pressed powder, coating is made tablet and (is contained coated tablet, plain sheet, Film coated tablets, chewable tablet, dispersible tablet, effervescent tablet, enteric coatel tablets, fast-release tablet, slow releasing tablet, controlled release tablet).
Capsule method for making of the present invention: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, seven flavor raw materials such as all the other Radixs Astragali directly feed intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65 (10～90 ℃) that filtrate is concentrated into relative density, put cold, add ethanol and make that to contain alcohol amount be 20～90%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.10～1.65 (10～90 ℃), adds Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing, make granule, or powder, with granule, or powder incapsulates, and makes capsule (containing soft capsule).
Pill method for making of the present invention: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, seven flavor raw materials such as all the other Radixs Astragali directly feed intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65 (10～90 ℃) that filtrate is concentrated into relative density, put cold, add ethanol and make that to contain alcohol amount be 20～90%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.10～1.65 (10～90 ℃), adds Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing, make granule, or powder, with granule, or powder incapsulates, and compacting or the general pill of making (contain honeyed pill, the watered pill, concentrated pill).
Medicine of the present invention has the following advantages:
1, the raw material selected for use of the present invention is the Nantural non-toxic plant amedica, and each component meets the pharmaceutical control and administration rules.Utilize the comprehensive function treatment apoplexy sequela of each raw material, no chemical addition agent, nontoxic to human body.
2, medicine of the present invention is a Chinese patent medicine, meets Chinese medical theory.The present invention serves as according to carrying out prescription, reuse the Radix Astragali with QI invigorating in the side with Traditional Chinese medical theory " QI and blood " theory, makes the prosperous blood of gas also row, blood stasis dispelling and just do not hinder; Be aided with Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Semen Persicae, Caulis Spatholobi, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; The Pheretima the meridian dredging.Play the effect of inrigorating qi and promoting blood circulation, removing blood stasis collateral dredging jointly.Full side collection QI invigorating, promoting blood circulation to remove obstruction in the collateral are one, have given prominence to high invigorating primordial QI, and the combination principle with fate blood reaches treating both the principal and the secondary aspects of a disease at the same time.Be the flexible prescription of the traditional Chinese medical science, dialectically execute an innovation of controlling, for benefiting QI for activating blood circulation treatment cardiovascular and cerebrovascular disease has been started a new treatment approach.Medicine of the present invention has QI invigorating, invigorates blood circulation, the collateral dredging function, is used for the treatment of the apoplexy sequela due to blood stagnancy due to deficiency of QI, the venation block, and disease is not just being seen soft unable, the deflective mouth and eye of hemiplegia, limb, dysphonia, slobbering, tongue body.
3, tablet of the present invention shows through the animal effect experiment: have blood viscosity lowering, accelerate erythrocyte electrophoretic time, and anticoagulant, antithrombotic forms, atherosclerosis, coronary blood flow increasing, the enhancing human body immunity function has antiinflammatory action.
4, tablet of the present invention shows through animal acute toxicity test, gives mouse stomach administration (be equivalent to clinical day dosage 2381 times), animal no abnormality seen with this product 750g/kg.Long term toxicity test: give the mice feed with 127.63 times of clinical daily dosage, continuous 90 days, weight of mice was normal as a result, and the outward appearance behavior is normal, and organs and tissues such as the heart, liver,spleen,kidney, brain are learned and checked the change of not finding drug-induced.The prompting clinical application should be safe.
5, tablet of the present invention shows that through the clinical hospital clinical test of three tame front threes following advantage is arranged:
5.1 tablet of the present invention carries out clinical trial 100 examples in first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, the People's Hospital, Guangxi district, selecting age, the state of an illness, pattern of syndrome and suitable apoplexy sequela 60 examples of Therapeutic Method be matched group, employing district group at random, the observation of experiment contrast method.The treatment group is taken tablet of the present invention, and every is equivalent to raw medicinal herbs 1.05 gram, 3 times on the one, one time 5, serve on for 4 weeks.Matched group is taken HUATUO ZAIZAO WAN, and 2 times on the one, one time 1 ball serve on for 4 weeks.The conventional physical examination of the previous crops of taking medicine is followed up a case by regular visits to weekly after taking medicine 1 time, inquires the situation of taking medicine, record change of illness state and side effect.Therapeutic outcome is evaluated with scoring method, and efficacy result is judged by the doctor in charge, and its therapeutic outcome sees Table 1, table 2.
The witness integration relatively before and after table 1, the treatment
| Grouping | The example number | Before the treatment | After the treatment | The P value | |
| The health giving quality project | The treatment group | 100 | 12.93±4.41 | 9.43±4.30 | ＞0.05 |
| Matched group | 60 | 12.41±4.41 | 9.01±4.39 | ||
| Traditional Chinese medical science witness project | The treatment group | 100 | 10.61±3.84 | 7.40±3.44 | ＞0.05 |
| Matched group | 60 | 10.46±3.97 | 7.15±3.71 |
Table 2, treatment group and matched group curative effect be (Rrdit analysis) relatively
| Grouping | The example number | Produce effects | Effectively | Invalid | R | U | P |
| The treatment group | 100 | 15 | 57 | 28 | 0.5099 | 0.4200 | ＞0.05 |
| Matched group | 60 | 6 | 36 | 18 | 0.4901 |
5.2 the observed object of tablet of the present invention is the apoplexy sequela patient that differential diagnosis in tcm is blood stagnancy due to deficiency of QI, venation block card, soft unable, the diseases such as the language plug is puckery, facial hemiparalysis of treatment back patient's hemiplegia, limb have clear improvement.
5.3 tablet clinical trial 100 routine total effective rates of the present invention are 72%, matched group HUATUO ZAIZAO WAN 60 routine effective percentage are 70%, its therapeutic effect unanimity.
5.4 in the tablet clinical trial of the present invention, do not find obvious adverse reaction and toxic and side effects, point out clinical use safe and reliable.
That 5.5 the present invention has is evident in efficacy, taking convenience, have no side effect, characteristics such as moderate cost.Have QI invigorating, invigorate blood circulation, the collateral dredging function, be used for the treatment of the apoplexy sequela due to blood stagnancy due to deficiency of QI, the venation block, disease is not just being seen soft unable, the deflective mouth and eye of hemiplegia, limb, dysphonia, slobbering, tongue body.
The specific embodiment
Embodiment 1:
With Flos Carthami 2g, Radix Salviae Miltiorrhizae 8g is ground into fine powder, all the other Radix Astragali 80g, Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 2g, Radix Paeoniae Rubra 3g, Pheretima 2g, Semen Persicae 2g, Caulis Spatholobi 2g is ground into coarse powder, with the Flos Carthami mixing, decoct with water first three times, secondary adds water 6 respectively, 4 times of amounts, decocted 2 hours, add 4 times of amounts of water for the third time, decocted collecting decoction 1 hour, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes that to contain alcohol amount be 70%, stir evenly, left standstill 24 hours, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35 (60 ℃), add Radix Salviae Miltiorrhizae fine powder and micropowder silica gel 4.8g, dried starch 2g, mixing, make granule, be pressed into 100, sugar coating is made tablet.
Embodiment 2:
With Flos Carthami 200g, Radix Salviae Miltiorrhizae 800g is ground into fine powder, all the other Radix Astragali 8000g, Radix Angelicae Sinensis 400g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 300g, Pheretima 200g, Semen Persicae 200g, Caulis Spatholobi 200g is ground into coarse powder, with the Flos Carthami mixing, decoct with water first three times, secondary adds water 6 respectively, 4 times of amounts, decocted 2 hours, add 4 times of amounts of water for the third time, decocted collecting decoction 1 hour, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes that to contain alcohol amount be 70%, stir evenly, left standstill 24 hours, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35 (60 ℃), add Radix Salviae Miltiorrhizae fine powder and micropowder silica gel 480g, dried starch 200g, mixing, make granule, be pressed into 10000, sugar coating is made tablet.
Embodiment 3:
With Flos Carthami 2g, Radix Salviae Miltiorrhizae 8g is ground into fine powder, all the other Radix Astragali 80g, Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 2g, Radix Paeoniae Rubra 3g, Pheretima 2g, Semen Persicae 2g, Caulis Spatholobi 2g is ground into coarse powder, with the Flos Carthami mixing, each amount of water is 6 times of amounts of raw material deal, and heating decocts 3 times, collecting decoction, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes that to contain alcohol amount be 70%, stir evenly, leave standstill, the leaching supernatant reclaims ethanol, being concentrated into relative density is the thick paste of 1.35 (60 ℃), add Radix Salviae Miltiorrhizae fine powder and Pulvis Talci, magnesium stearate is an amount of, and mixing is made granule, encapsulated, make capsule.
Embodiment 4:
With Flos Carthami 200g, Radix Salviae Miltiorrhizae 800g is ground into fine powder, all the other Radix Astragali 8000g, Radix Angelicae Sinensis 400g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 300g, Pheretima 200g, Semen Persicae 200g, Caulis Spatholobi 200g is ground into coarse powder, with the Flos Carthami mixing, each amount of water is 6 times of amounts of raw material deal, and heating decocts 3 times, collecting decoction, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes that to contain alcohol amount be 70%, stir evenly, leave standstill, the leaching supernatant reclaims ethanol, being concentrated into relative density is the thick paste of 1.35 (60 ℃), add Radix Salviae Miltiorrhizae fine powder and Pulvis Talci, magnesium stearate is an amount of, and mixing is made granule, encapsulated, make capsule.
Embodiment 5:
With Flos Carthami 2g, Radix Salviae Miltiorrhizae 8g is ground into fine powder, all the other Radix Astragali 80g, Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 2g, Radix Paeoniae Rubra 3g, Pheretima 2g, Semen Persicae 2g, Caulis Spatholobi 2g is ground into coarse powder, with the Flos Carthami mixing, each amount of water is 6 times of amounts of raw material deal, and heating decocts 3 times, collecting decoction, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts cold, add ethanol and make that to contain alcohol amount be 70%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.35 (60 ℃), adds Radix Salviae Miltiorrhizae fine powder and Pulvis Talci, magnesium stearate is an amount of, mixing, dry, be ground into fine powder, be pressed into ball, make concentrated pill.
Embodiment 6:
With Flos Carthami 200g, Radix Salviae Miltiorrhizae 800g is ground into fine powder, all the other Radix Astragali 8000g, Radix Angelicae Sinensis 400g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 300g, Pheretima 200g, Semen Persicae 200g, Caulis Spatholobi 200g is ground into coarse powder, with the Flos Carthami mixing, each amount of water is 6 times of amounts of raw material deal, and heating decocts 3 times, collecting decoction, filter, it is 1.20 (60 ℃) that filtrate is concentrated into relative density, puts cold, add ethanol and make that to contain alcohol amount be 70%, stir evenly, leave standstill, the leaching supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.35 (60 ℃), adds Radix Salviae Miltiorrhizae fine powder and Pulvis Talci, magnesium stearate is an amount of, mixing, dry, be ground into fine powder, the general ball of making is made watered pill.
Claims (4)
1, a kind of stilbene blood collateral dredging medicine is characterized in that being made by following materials of weight proportions: 40～2000 parts of the Radixs Astragali, 2～100 parts of Radix Angelicae Sinensis, 1～50 part of Rhizoma Chuanxiong, 1.5～75 parts of Radix Paeoniae Rubra, 1～50 part of Pheretima, 1～50 part in Semen Persicae, 1～50 part on Flos Carthami, 1～50 part of Caulis Spatholobi, 4～200 parts of Radix Salviae Miltiorrhizaes.
2, stilbene blood collateral dredging medicine according to claim 1 is characterized in that being made by following materials of weight proportions: 40 parts of the Radixs Astragali, 2 parts of Radix Angelicae Sinensis, 1 part of Rhizoma Chuanxiong, 1.5 parts of Radix Paeoniae Rubra, 1 part of Pheretima, 1 part in Semen Persicae, 1 part on Flos Carthami, 1 part of Caulis Spatholobi, 4 parts of Radix Salviae Miltiorrhizaes.
3, stilbene blood collateral dredging medicine according to claim 1 and 2 is characterized in that: adopt the method for galenic pharmacy to make regular dosage form, dosage form is a granule; Capsule contains soft capsule; Tablet contains coated tablet, plain sheet, Film coated tablets, chewable tablet, dispersible tablet, effervescent tablet, enteric coatel tablets, fast-release tablet, slow releasing tablet, controlled release tablet; Pill contains honeyed pill, the watered pill, concentrated pill.
4, the preparation method of stilbene blood collateral dredging medicine according to claim 1 and 2, it is characterized in that may further comprise the steps: with Flos Carthami, Radix Salviae Miltiorrhizae powder is broken into fine powder, all the other Radixs Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Pheretima, Semen Persicae, Sanguis Gallus domesticus TENGQI (sic) flavor raw material directly feeds intake, or be ground into coarse powder, with the Flos Carthami mixing, amount of water is 1～14 times of amount of raw material deal, heating decocts 1～6 time, collecting decoction, filter, it is 1.05～1.65/10～90 ℃ that filtrate is concentrated into relative density, put coldly, add ethanol and make that to contain alcohol amount be 20～90%, stir evenly, leave standstill, the leaching supernatant reclaims ethanol, is concentrated into relative density and is 1.10～1.65/10～90 ℃ thick paste, add Radix Salviae Miltiorrhizae fine powder and starch, or sucrose, or mannitol, or pregelatinized Starch, or Pulvis Talci, or microcrystalline Cellulose, or carboxymethyl starch sodium, or crospolyvinylpyrrolidone, or magnesium stearate, or micropowder silica gel is wherein a kind of, or several mixture are an amount of, mixing is made granule, or powder, make granule; Or granule or powder incapsulated, make capsule; Or, become plain sheet or coating with granule or pressed powder, make tablet; Or, make pill with granule or powder.
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| CN101310737B (en) * | 2007-08-10 | 2011-08-31 | 赵玉英 | Medicine for treating ischemic stroke and its preparation method |
| CN101396441B (en) * | 2007-09-26 | 2011-11-30 | 首都医科大学附属北京友谊医院 | Traditional Chinese medicine composition for treating blood stasis syndrome of multi viscera organs incompetence syndrome |
| CN102657754A (en) * | 2012-05-23 | 2012-09-12 | 通化中西医结合血栓病研究所 | Thrombus collaterals-dredging medicament |
| CN102670893A (en) * | 2012-05-31 | 2012-09-19 | 刘大男 | Traditional Chinese medicine composition for treating atherosclerosis |
| CN103263502A (en) * | 2013-05-03 | 2013-08-28 | 山东科技大学 | Medicament for treating cerebrovascular disease sequelae |
| CN103655727A (en) * | 2013-12-09 | 2014-03-26 | 贵州信邦制药股份有限公司 | Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof |
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| CN112891432A (en) * | 2021-04-09 | 2021-06-04 | 湖南三真康复医院股份有限公司 | A Chinese medicinal granule for treating apoplexy and preparation method thereof |
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| CN101396441B (en) * | 2007-09-26 | 2011-11-30 | 首都医科大学附属北京友谊医院 | Traditional Chinese medicine composition for treating blood stasis syndrome of multi viscera organs incompetence syndrome |
| CN102657754A (en) * | 2012-05-23 | 2012-09-12 | 通化中西医结合血栓病研究所 | Thrombus collaterals-dredging medicament |
| CN102657754B (en) * | 2012-05-23 | 2013-10-09 | 通化中西医结合血栓病研究所 | Thrombus collaterals-dredging medicament |
| CN102670893A (en) * | 2012-05-31 | 2012-09-19 | 刘大男 | Traditional Chinese medicine composition for treating atherosclerosis |
| CN103263502A (en) * | 2013-05-03 | 2013-08-28 | 山东科技大学 | Medicament for treating cerebrovascular disease sequelae |
| CN103655727A (en) * | 2013-12-09 | 2014-03-26 | 贵州信邦制药股份有限公司 | Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof |
| CN103735584A (en) * | 2014-01-21 | 2014-04-23 | 谢国清 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases |
| CN103735584B (en) * | 2014-01-21 | 2016-09-07 | 谢国清 | The Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease |
| CN104758649A (en) * | 2015-03-26 | 2015-07-08 | 王军红 | Traditional Chinese medicine composition for treating numbness of limbs |
| CN106038809A (en) * | 2016-08-09 | 2016-10-26 | 张志红 | Traditional Chinese medicine composition for treating cerebral thrombosis |
| CN112891432A (en) * | 2021-04-09 | 2021-06-04 | 湖南三真康复医院股份有限公司 | A Chinese medicinal granule for treating apoplexy and preparation method thereof |
| CN115813972A (en) * | 2022-09-23 | 2023-03-21 | 梅小平 | Zhuang medicine compound medicine for treating ischemic stroke in acute stage and preparation method thereof |
| CN115813972B (en) * | 2022-09-23 | 2023-09-12 | 梅小平 | Zhuang medicine compound medicine for treating acute stage of ischemic stroke and preparation method thereof |
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