CN103655727A - Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof - Google Patents
Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing the healthy qi, and a preparation method thereof. The preparation method comprises the following steps: preparing the following raw medicinal materials in parts by weight: 100 to 140 parts of radix astragali and 50 to 70 parts of ligustrum lucidum, decocting with water, extracting the effective components, adding a proper amount of auxiliary materials, wherein the auxiliary materials comprise: filing materials, which is composed of the following raw materials: 100 to 230 parts of starch, 75 to 90 parts of cane sugar, and 15 to 18 parts of micropowder silica gel, and a disintegrating agent, namely low-substituted hydroxypropyl cellulose accounting for 1% to 5% of the total weight of the raw medicinal material extract and the auxiliary materials. The condensed pill provided by the invention can prominently reduced the oral in-take dosage, is convenient to store and take, is easy to dissolve and absorb, and can prominently improve the clinical curative effect.
Description
Technical field
The present invention relates to a kind of body resistance-strengthening Zhenqi concentrated pill and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Zhenqi Fuzheng medicine be with the plant amedica Radix Astragali and Fructus Ligustri Lucidi, carry out assembly production for improving immunity, treatment, cause the medicine of leukopenia because of radiotherapy or chemotherapy.Zhenqi Fuzheng medicine has tablet, capsule, granule and drop pill for the dosage form of selection of clinical at present; Wherein, but these dosage forms are due to reasons such as preparation technologies, mostly after taking, have that dissolve scattered time limit is long, dissolution is low, it is poor to absorb, bioavailability is lower and the defect such as dose is larger.
Concentrated pill is the product that Chinese Traditional Medicine combines with modern technologies, has not only embodied the advance of modern pharmaceutical technology, and has kept that traditional pill is not perishable, curative effect is lasting, dose is little, portable advantage.Meanwhile, the ball shape of concentrated pill is little, is easier to swallow for tablet; The ingredient of concentrated pill is concentrated, and with respect to traditional watered pill and big honeyed pills, one time dose is less.In addition, compare with tablet, in the production process of concentrated pill, also reduced the operations such as granulation, coating, thereby can reduce production costs, alleviate patient economy burden, to doctor and patient, provide more pharmaceutical formulation to select space.Through retrieval, also there is no at present the relevant report about body resistance-strengthening Zhenqi concentrated pill.
Summary of the invention
The object of the invention is to, a kind of body resistance-strengthening Zhenqi concentrated pill and preparation method thereof is provided, it can effectively solve the shortcoming existing in prior art, provides a kind of and is easy to stripping and absorption, is convenient to preserve and take, the significant body resistance-strengthening Zhenqi novel formulation of therapeutic effect.
For solving the problems of the technologies described above, the present invention adopts following technical scheme:
A body resistance-strengthening Zhenqi concentrated pill, calculates by weight, and it is that to take 50～70 parts of 100～140 parts of the Radixs Astragali and Fructus Ligustri Lucidi be crude drug, after water boiling and extraction effective ingredient, adds appropriate amount of auxiliary materials to make; Described adjuvant comprises filler, be 15～18 parts of 100～230 parts of starch, 75～90 parts of sucrose and micropowder silica gels, and disintegrating agent, be the low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 1%～5%.
Preferably, calculate by weight, it is that to take 60 parts of 120 parts of the Radixs Astragali and Fructus Ligustri Lucidi be crude drug, after water boiling and extraction effective ingredient, adds appropriate amount of auxiliary materials to make; Described adjuvant comprises filler, be 17 parts of 210 parts of starch, 83 parts of sucrose and micropowder silica gels, and disintegrating agent, be the low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 3%.
The preparation method of body resistance-strengthening Zhenqi concentrated pill, is broken into coarse powder by the Radix Astragali and Fructus Ligustri Lucidi powder as mentioned above, and water decocts 2～4 times, adds for the first time 6～10 times of water gagings, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1～2 hour, filters filtrate for later use; The slag of getting it filled adds 6～10 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 0.5～1.5 hour at every turn, filters; Merge all medicinal liquids, filter, filtrate decompression is condensed into clear paste, filters, and clear paste is mixed with starch, and dry granulation, is broken into fine powder by granular powder, adds sucrose, micropowder silica gel and disintegrating agent, and mix homogeneously, obtains mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
Preferred preparation method: the Radix Astragali and Fructus Ligustri Lucidi powder are broken into coarse powder, and water decocts 2～4 times, adds for the first time 6～10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 1～2 hour, filters filtrate for later use; The slag of getting it filled adds 6～10 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 0.5～1.5 hour at every turn, filters; Merge all medicinal liquids, filter, filtrate is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under 60～80 ℃, the vacuum condition that is 0.06～0.07Mpa in temperature, filtering, clear paste is mixed with starch, is that 0.4MPa, steam pressure are that 0.4～0.6MPa, baking temperature are next step dry granulation of condition of 50～80 ℃ at spray pressure, granular powder is broken into fine powder, add sucrose, micropowder silica gel and disintegrating agent, mix homogeneously, obtains mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
Preferred preparation method: the Radix Astragali and Fructus Ligustri Lucidi powder are broken into coarse powder, and water decocts 3 times, adds for the first time 10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 2 hours, medicine juice filters through 100 mesh sieves, filtrate for later use; The slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1 hour at every turn, medicine juice filters through 100 mesh sieves; Merge all medicinal liquids, filter, filtrate is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under 60～80 ℃, the vacuum condition that is 0.06～0.07Mpa in temperature, through 100 mesh sieves, filter, clear paste is mixed with starch, at spray pressure, be that 0.4MPa, steam pressure are that 0.4～0.6MPa, baking temperature are next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add sucrose, micropowder silica gel and disintegrating agent, cross 80～100 mesh sieves, mix 80 minutes, obtain mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
Specifically, described concentrated watered pill is prepared like this: in gained mixing fine powders, adding cold boiled water or Diluted Alcohol, mix, is that 0.40～0.60Mpa, baking temperature are to be dried under 45～80 ℃, the condition of moisture≤9.0% in steam pressure, general controlling the water circulation ball, obtains.
Described concentrated honeyed pill is prepared like this: in every 100g mixing fine powders, adding refined honey 80～90g, mix, is that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤15.0% in steam pressure, is prepared into concentrated honeyed pill.
Described condensed water honeyed pill is prepared like this: in every 100g mixing fine powders, adding refined honey 40～60g, mix, is that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤12.0% in steam pressure, is prepared into condensed water honeyed pill.
Also the prepared concentrated watered pill of the present invention, concentrated honeyed pill or condensed water honeyed pill can be carried out to coating, as add appropriate amount of auxiliary materials (sucrose, Pulvis Talci, carmine etc.) sugar coating; Or add appropriate amount of auxiliary materials (hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone etc.) film coating.
In order to ensure effect of the present invention, the applicant has carried out the preparation process condition that series of experiments screens body resistance-strengthening Zhenqi concentrated pill, guaranteeing its science, reasonable, feasible.Specific as follows:
Experimental example 1: Study on extraction
By trial test, extraction process by water research is shown: amount of water, decocting time and decoction number of times are larger to the content influence of body resistance-strengthening Zhenqi concentrated pill effective ingredient.Amount of water, decocting time, the every factor of decoction number of times are established to 3 level values, and take Astragaloside content and carry out L as evaluation index
9(3
3) test, decoction process guarantees boiling, and extracting solution is condensed into thick paste, and drying under reduced pressure obtains dry extract, calculates paste-forming rate, and factor and level be in Table 1, testing program and the results are shown in Table 2:
The extraction process orthogonal test factor level of table 1 body resistance-strengthening Zhenqi concentrated pill
Table 2 orthogonal test L9 (33) result and comprehensive grading intuitive analysis
By above-mentioned orthogonal experiments, shown: factor amount of water C is larger to the quality influence of extract powder, and the impact of factor decoction number of times A, decocting time B is less.Therefore best extraction process by water is A
2b
1c
3, decocting number of times is 3 times, 10 times of water gagings decoct 2h; Industrial, this condition can suitably change into: add for the first time 10 times of water gagings and decoct 2h, add for the second time and for the third time 8 times of water gagings and decoct 1h.
Experimental example 2: concentration technology research
In order to avoid, high temperature is concentrated causes hot-spot, causes grabbing pot, caking, and the destruction that even causes effective ingredient meanwhile, is to shorten concentration time, reduce effective ingredient and extend the probability reducing because of heated time, this process using be concentrating under reduced pressure.Concentrating under reduced pressure had both shortened concentration time, had retained to greatest extent again effective ingredient.
Experimental example 3: preparation process research
(1) screening study of filler
For concentrated pill preparation, conventionally with starch, as filler, adjust the specification size of pill.To the concentrated pill below specification 6g, according to the needs of preparation prescription amount, when the Radix Astragali and Fructus Ligustri Lucidi consumption are respectively 100～140g, 50～70g, starch consumption is suitably adjusted within the scope of 100～230g.
Simultaneously, Chinese medicine extraction liquid spraying drying efficiency is high, and gained extract powder evenly, fine and smooth, water content is low, dissolubility is fabulous, but because specific surface area is very large, thereby the easy moisture absorption, viscosity is strong, easily adhesion is agglomerating, the difficulty of granulating, must add suitable filler and with reduction extract powder, draw moistly, and is beneficial to and prepares soft material and granulation.
The evaluation of pelletization difficulty presses out the now probability of row phenomenon and marks, and (A) viscosity is excessive, granulating difficulty; (B) in granule, there is bar to produce; (C) particle size distribution great disparity; (D) hard after particle drying (stiff grain); (E) granule uneven shade, easily whitens a little; (F) granule degree of tightness is improper; (G) too loose, granulating difficulty.Above A～G is every, and meter of every appearance one minute, can repeat score.Result of each formula is as following table 3:
Table 3 reduces the screening study of drawing moist filler
By table 3, can be found: add micropowder silica gel can improve drawing of extract powder moist, particularly sucrose and micropowder silica gel are used in conjunction with proper proportion, both it is moist to have improved drawing of granule, in the time of overcoming preferably again granulation, easily lump, adhere to, stir inequality, block the shortcomings such as screen cloth, granule yield is high, and filler loading is few, cost is low.When microcrystalline Cellulose and sucrose share, granulate easily, granule is difficult for drawing wet, but measure dissolve when large not good, the alone sucrose difficulty of granulating.
(2) screening of medicated powder fineness
The fineness of medicated powder also can affect the preparation of concentrated pill, and applicant screens the fineness of medicated powder, and result of the test is in Table 4:
The selection result of study of table 4 medicated powder fineness
As shown in Table 4: adopt the general ball of 80～100 object fine powder, the pill glowing surface exquisiteness, smooth rounding, and owing to having increased the total surface area of medicated powder, thereby can make human body can absorb more fully effective ingredient wherein, strengthened pharmaceutical effectiveness; Medicated powder is thicker to cross 65 orders, the pill rough surface of general one-tenth, affect pill outward appearance, and have piebaldism and fiber hair, and easy-formation not; Powder is meticulous to cross 120 orders, and when molding, powder can closely be heaped mutually, and too much fine powder is embedded in intergranular hole, and therefore general ball medication powder is also unsuitable meticulous.
(3) screening of disintegrating agent kind and consumption
The screening of disintegrating agent kind
Select four kinds of different disintegrating agents: low-substituted hydroxypropyl cellulose (L-HPC), carboxymethyl starch sodium (CMS-Na), cross-linking sodium carboxymethyl cellulose (CCMCNa), crospolyvinylpyrrolidone (PVPP), measure external disintegration time, result of the test is in Table 5:
Table 5 adds the disintegration time (x ± s) of different disintegrating agents
From upper table 5, CCNa and L-HPC as the prescription disintegration time of disintegrating agent all in 30s; From economics, consider, CCNa is slightly more cheap than L-HPC, but considers, and the present invention selects L-HPC as disintegrating agent.Contrary, the disintegration time of CMS-Na sheet is the longest, because of rapid swelling after its water suction, easily forms gel, has hindered the rapid osmotic of moisture, therefore makes the disintegration time of tablet also longer.
The screening of L-HPC consumption
Because L-HPC has very large surface area and porosity, so have good absorption speed and water absorption, its expansion rate of water absorption is when 500%～700%(replaces fiduciary point 10%～15%), the granule after disintegrate is also more tiny, so be conducive to the stripping of medicine.After determining that employing L-HPC is disintegrating agent of the present invention, we investigate its consumption again, the results are shown in Table 6:
The screening of table 6L-HPC consumption
As shown in Table 6: along with the increase of L-HPC addition, the hardness of pill and disintegrate ability all increase gradually, and when the addition of L-HPC is 5%, hardness reaches Appropriate, and disintegrate ability meets the requirement of concentrated pill; When the addition of L-HPC continues to increase, the hardness of pill starts higher.So by the factors such as disintegration time, dissolution rate, hardness are carried out after integrated survey, the L-HPC of 1%～5% recipe quantity is all suitable, the L-HPC of 3% recipe quantity (described recipe quantity refers to the gross weight of crude drug extract and adjuvant) is best.
(4) dissolution of different preparations is investigated
The stripping meeting of medicine directly affects its absorption and utilization in vivo, is an inherent index of Control of drug quality.According to the method for the invention, prepare concentrated pill; According to prescription of the present invention, prepare routinely the method for tablet and prepare tablet, record both dissolutions, result of the test is in Table 7:
Table 7
As shown in Table 7: each stripping parameter of concentrated pill, lower than tablet, shows that the dissolution of concentrated pill is better than tablet.
(5) bioavailability of different preparations is investigated
The bioavailability metrics of above-mentioned two kinds of preparations is in Table 8:
Table 8
Experiment shows: the bioavailability of pill is obviously greater than tablet.This is due to through impalpable powder technique, has greatly increased the dissolution rate of effective ingredient, thereby has increased medicine infiltration rate in vivo.
(6) drug efficacy study
Effect to the hemocytes increasing protection bone marrow adrenal cortex of body resistance-strengthening Zhenqi concentrated pill of the present invention and liver function and the generation of promotion interferon is studied.
One, material:
1, medicine: Zhenqi dripping pill for strengthening resistance: according to application number be 200610054828.0, name is called the method preparation of " Zhenqi dripping pill for strengthening resistance ";
Preparation of the present invention: prepare according to the method for the invention.
2, animal: mice, by Guiyang Medical College, provided, body weight 26～30g, counts 60.
Two, experimental technique and result
1, hemocytes increasing protection bone marrow adrenal cortex and liver functional experiment: get 30 of mices, male and female half and half, are divided into 3 groups at random, are respectively matched group, Zhenqi dripping pill for strengthening resistance group, preparation group of the present invention.Each administration group is gastric infusion 20mL/kg according to dosage, and matched group gives equal-volume normal saline, and after 1 hour, every Mus is drawn and coughs with strong aqua ammonia 0.1mL spraying, take erythrocyte content as index, observes the impact of medicine on Mouse Blood cell content, the results detailed in Table 9:
Table 9
| Group | Dosage (mLkg -1） | Erythrocyte content/L |
| Matched group | － | 4.5×10 12 |
| Zhenqi dripping pill for strengthening resistance group | 20 | 5.0×10 12 |
| Preparation group of the present invention | 20 | 6.0×10 12 |
As shown in Table 9: preparation group of the present invention is compared with matched group and Zhenqi dripping pill for strengthening resistance group, P<0.01; Visible, to compare with Zhenqi dripping pill for strengthening resistance group, preparation group mouse red blood cell content of the present invention is higher, thereby is more conducive to protect bone marrow adrenal cortex and liver function.
2, mice secretion interferon experiment: get 30 of mices, male and female half and half, are divided into 3 groups at random, are respectively matched group, Zhenqi dripping pill for strengthening resistance group, preparation group of the present invention.Before each group experiment, water 24h is can't help in fasting, gastric infusion, and administration volume is 0.2mL/10g, blank group gives equal-volume distilled water, after 60 minutes, respectively organizes the secretory volume of mouse interferon, the results are shown in Table 10:
Table 10
As shown in Table 10: preparation group of the present invention is compared with matched group, P<0.01; Compare P<0.05 with Zhenqi dripping pill for strengthening resistance group; Visible, preparation group of the present invention is compared with Zhenqi dripping pill for strengthening resistance group, and the interferon secretory volume of mice significantly increases.
More than experiment shows: preparation of the present invention and the comparison of Zhenqi dripping pill for strengthening resistance group, and the generation of hemocyte is more, thereby can better protect bone marrow adrenal cortex and liver function; Can promote that in addition mice secretes more interferon, thereby more be conducive to improve the immunologic function of body.
Compared with prior art, body resistance-strengthening Zhenqi concentrated pill of the present invention is by Fructus Ligustri Lucidi, Milkvetch Root are extracted, in extractum, add the pill that suitable adjuvant is made, compare with full powder pill and existing Zhenqi Fuzheng prepn, can significantly reduce taking dose, be convenient to preserve and take simultaneously, be easy to stripping and absorption, can significantly improve clinical efficacy.Specifically, the present invention is by adding adjuvant filler and disintegrating agent in the extraction clear paste at Fructus Ligustri Lucidi and the Radix Astragali, thereby it is moist to improve drawing of clear paste powder, particularly by filler---sucrose and micropowder silica gel are used in conjunction with proper proportion, both it is moist to have improved drawing of granule, can overcome preferably again while granulating and easily lump, adhere to, stir uneven, block the shortcomings such as screen cloth, adopt disintegrating agent simultaneously---the low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 1%～5%, due to its hygroscopicity and water absorption better, thereby can overcome pill rough surface and the problem such as dry and cracked.In addition, the present invention, in obtaining the process of medicine juice, filters medicine juice through 100 mesh sieves, thereby the impurity in medicinal liquid or medicinal residues can be got rid of completely; And if through 80 mesh sieves filtrations, medicinal liquid can totally not affecting sprays be dried and pill operation because fine impurities is removed, cause shower nozzle often to stop up and the crude problem of pill appearance below.In addition, it is also for impurity wherein or medicinal residues are got rid of completely that the clear paste in the present invention filters through 100 mesh sieves, improves spraying and is dried and pill effect.In addition, spray pressure of the present invention is 0.4MPa, thereby is convenient to medicinal liquid is uniform and fine powder combination drying; Steam pressure is 0.4～0.6MPa, thereby is convenient to control baking temperature; Baking temperature is 50～80 ℃, thereby can effectively control the molding of content and the preparation of concentrated pill, if temperature is higher than 80 ℃, can affect on the one hand the content of preparation, some volatile matters in preparation are vapored away, cause content to reduce, on the other hand, also can cause pill cracking, thereby affect preparations shaping.
The specific embodiment
Embodiments of the invention 1: the concrete preparation method of body resistance-strengthening Zhenqi concentrated watered pill is: Radix Astragali 120g, Fructus Ligustri Lucidi 60g are ground into coarse powder, water decocts 3 times, add for the first time 10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decoct 2 hours, medicine juice filters through 100 mesh sieves, filtrate for later use, the slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1 hour at every turn, medicine juice filters through 100 mesh sieves, merge all medicinal liquids, filter, filtrate is 60～80 ℃ in temperature, vacuum is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under the condition of 0.06～0.07Mpa, through 100 mesh sieves, filter, clear paste is mixed with 210g starch, at spray pressure, be 0.4MPa, steam pressure is 0.4～0.6MPa, baking temperature is next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add 83g sucrose, 17g micropowder silica gel, disintegrating agent (low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 3%), cross 80～100 mesh sieves, mix 80 minutes, obtain mixing fine powders, adding cold boiled water or Diluted Alcohol, mix, is that 0.40～0.60Mpa, baking temperature are to be dried under 45～80 ℃, the condition of moisture≤9.0% in steam pressure, and general controlling the water circulation ball, obtains.According to making the watered pill below 6g under pill regularization term, each serving consumption by primary crude drug 12.5g, every day 2 times.
Embodiment 2: the concrete preparation method of the concentrated honeyed pill of body resistance-strengthening Zhenqi is: Radix Astragali 120g, Fructus Ligustri Lucidi 60g are ground into coarse powder, and water decocts 3 times, adds for the first time 10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 2 hours, medicine juice filters through 100 mesh sieves, filtrate for later use, the slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1 hour at every turn, medicine juice filters through 100 mesh sieves, merge all medicinal liquids, filter, filtrate is 60～80 ℃ in temperature, vacuum is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under the condition of 0.06～0.07Mpa, through 100 mesh sieves, filter, clear paste is mixed with 210g starch, at spray pressure, be 0.4MPa, steam pressure is 0.4～0.6MPa, baking temperature is next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add 83g sucrose, 17g micropowder silica gel, disintegrating agent (low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 4%), cross 80～100 mesh sieves, mix 80 minutes, obtain mixing fine powders, every 100g mixing fine powders adds refined honey 80～90g, mixes, and in steam pressure, be that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤15.0%, be prepared into concentrated honeyed pill.According to the concentrated honeyed pill of making under pill regularization term below 6g, each serving consumption by primary crude drug 12.5g, every day 2 times.
Embodiment 3: the preparation method of body resistance-strengthening Zhenqi condensed water honeyed pill is: Radix Astragali 120g, Fructus Ligustri Lucidi 60g are ground into coarse powder, and water decocts 3 times, adds for the first time 10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 2 hours, medicine juice filters through 100 mesh sieves, filtrate for later use, the slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1 hour at every turn, medicine juice filters through 100 mesh sieves, merge all medicinal liquids, filter, filtrate is 60～80 ℃ in temperature, vacuum is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under the condition of 0.06～0.07Mpa, through 100 mesh sieves, filter, clear paste is mixed with 210g starch, at spray pressure, be 0.4MPa, steam pressure is 0.4～0.6MPa, baking temperature is next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add 83g sucrose, 17g micropowder silica gel, disintegrating agent (low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 2%), cross 80～100 mesh sieves, mix 80 minutes, obtain mixing fine powders, every 100g mixing fine powders adds refined honey 40～60g, mixes, and in steam pressure, be that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤12.0%, be prepared into condensed water honeyed pill.According to the condensed water honeyed pill of making under pill regularization term below 6g, each serving consumption by primary crude drug 12.5g, every day 2 times.
Embodiment 4: a kind of preparation method of body resistance-strengthening Zhenqi concentrated pill, Radix Astragali 140g, Fructus Ligustri Lucidi 70g are ground into coarse powder, and water decocts 4 times, adds for the first time 8 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 2 hours, filters filtrate for later use, the slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1.5 hours at every turn, filters, merge all medicinal liquids, filter, filtrate is 60～80 ℃ in temperature, vacuum is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under the condition of 0.06～0.07Mpa, filter, clear paste is mixed with 230g starch, at spray pressure, be 0.4MPa, steam pressure is 0.4～0.6MPa, baking temperature is next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add 90g sucrose, 18g micropowder silica gel, disintegrating agent (low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 5%), cross 100 mesh sieves, mix homogeneously, obtain mixing fine powders, adding cold boiled water or Diluted Alcohol, mix, is that 0.40～0.60Mpa, baking temperature are to be dried under 45～80 ℃, the condition of moisture≤9.0% in steam pressure, and general controlling the water circulation ball, obtains concentrated watered pill.According to making the concentrated watered pill below 6g under pill regularization term, each serving consumption by primary crude drug 12.5g, every day 2 times.
Embodiment 5: a kind of preparation method of body resistance-strengthening Zhenqi concentrated pill, Radix Astragali 100g, Fructus Ligustri Lucidi 50g are ground into coarse powder, and water decocts 2 times, adds for the first time 8 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 1 hour, filters filtrate for later use, the slag of getting it filled, adds 6 times of water gagings, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 0.5 hour, filters, merge all medicinal liquids, filter, filtrate is 60～80 ℃ in temperature, vacuum is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under the condition of 0.06～0.07Mpa, filter, clear paste is mixed with 100g starch, at spray pressure, be 0.4MPa, steam pressure is 0.4～0.6MPa, baking temperature is next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add 75g sucrose, 15g micropowder silica gel, disintegrating agent (low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 1%), cross 80 mesh sieves, mix homogeneously, obtain mixing fine powders, every 100g mixing fine powders adds refined honey 80～90g, mixes, and in steam pressure, be that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤15.0%, be prepared into concentrated honeyed pill.According to the concentrated honeyed pill of making under pill regularization term below 6g, each serving consumption by primary crude drug 12.5g, every day 2 times.
The prepared concentrated watered pill of above-described embodiment, concentrated honeyed pill or condensed water honeyed pill be further coating also, as adds appropriate amount of auxiliary materials (sucrose, Pulvis Talci, carmine etc.) sugar coating; Or add appropriate amount of auxiliary materials (hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone etc.) film coating.
Claims (8)
1. a body resistance-strengthening Zhenqi concentrated pill, is characterized in that: calculate by weight, it is that to take 50～70 parts of 100～140 parts of the Radixs Astragali and Fructus Ligustri Lucidi be crude drug, after water boiling and extraction effective ingredient, adds appropriate amount of auxiliary materials to make; Described adjuvant comprises filler, be 15～18 parts of 100～230 parts of starch, 75～90 parts of sucrose and micropowder silica gels, and disintegrating agent, be the low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 1%～5%.
2. body resistance-strengthening Zhenqi concentrated pill according to claim 1, is characterized in that: calculate by weight, it is that to take 60 parts of 120 parts of the Radixs Astragali and Fructus Ligustri Lucidi be crude drug, after water boiling and extraction effective ingredient, adds appropriate amount of auxiliary materials to make; Described adjuvant comprises filler, be 17 parts of 210 parts of starch, 83 parts of sucrose and micropowder silica gels, and disintegrating agent, be the low-substituted hydroxypropyl cellulose of crude drug extract and adjuvant total amount 3%.
3. the preparation method of body resistance-strengthening Zhenqi concentrated pill as claimed in claim 1 or 2, is characterized in that: the Radix Astragali and Fructus Ligustri Lucidi powder are broken into coarse powder, and water decocts 2～4 times, add for the first time 6～10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decoct 1～2 hour, filter filtrate for later use; The slag of getting it filled adds 6～10 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 0.5～1.5 hour at every turn, filters; Merge all medicinal liquids, filter, filtrate decompression is condensed into clear paste, filters, and clear paste is mixed with starch, and dry granulation, is broken into fine powder by granular powder, adds sucrose, micropowder silica gel and disintegrating agent, and mix homogeneously, obtains mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
4. the preparation method of body resistance-strengthening Zhenqi concentrated pill according to claim 3, is characterized in that: the Radix Astragali and Fructus Ligustri Lucidi powder are broken into coarse powder, and water decocts 2～4 times, add for the first time 6～10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decoct 1～2 hour, filter filtrate for later use; The slag of getting it filled adds 6～10 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 0.5～1.5 hour at every turn, filters; Merge all medicinal liquids, filter, filtrate is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under 60～80 ℃, the vacuum condition that is 0.06～0.07Mpa in temperature, filtering, clear paste is mixed with starch, is that 0.4MPa, steam pressure are that 0.4～0.6MPa, baking temperature are the further granulation that is dried under the condition of 50～80 ℃ at spray pressure, granular powder is broken into fine powder, add sucrose, micropowder silica gel and disintegrating agent, mix homogeneously, obtains mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
5. the preparation method of body resistance-strengthening Zhenqi concentrated pill according to claim 4, it is characterized in that: the Radix Astragali and Fructus Ligustri Lucidi powder are broken into coarse powder, water decocts 3 times, add for the first time 10 times of water gagings, Steam Heating, steam pressure is 0.1～0.25MPa, decocts 2 hours, medicine juice filters through 100 mesh sieves, filtrate for later use; The slag of getting it filled adds 8 times of water gagings afterwards at every turn, Steam Heating, and steam pressure is 0.1～0.25MPa, decocts 1 hour at every turn, medicine juice filters through 100 mesh sieves; Merge all medicinal liquids, filter, filtrate is to be evaporated to the clear paste that 50～70 ℃ of relative densities are 1.15～1.18 under 60～80 ℃, the vacuum condition that is 0.06～0.07Mpa in temperature, through 100 mesh sieves, filter, clear paste is mixed with starch, at spray pressure, be that 0.4MPa, steam pressure are that 0.4～0.6MPa, baking temperature are next step dry granulation of condition of 50～80 ℃, granular powder is broken into fine powder, add sucrose, micropowder silica gel and disintegrating agent, cross 80～100 mesh sieves, mix 80 minutes, obtain mixing fine powders; By the moulding process of concentrated pill, be prepared into concentrated watered pill, concentrated honeyed pill or condensed water honeyed pill.
6. according to the preparation method of the body resistance-strengthening Zhenqi concentrated pill described in claim 3,4 or 5, it is characterized in that, described concentrated watered pill is prepared like this: in gained mixing fine powders, add cold boiled water or Diluted Alcohol, mix, in steam pressure, be that 0.40～0.60Mpa, baking temperature are to be dried under 45～80 ℃, the condition of moisture≤9.0%, general controlling the water circulation ball, obtains.
7. according to the preparation method of the body resistance-strengthening Zhenqi concentrated pill described in claim 3,4 or 5, it is characterized in that, described concentrated honeyed pill is prepared like this: in every 100g mixing fine powders, add refined honey 80～90g, mix, in steam pressure, be that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤15.0%, be prepared into concentrated honeyed pill.
8. according to the preparation method of the body resistance-strengthening Zhenqi concentrated pill described in claim 3,4 or 5, it is characterized in that, described condensed water honeyed pill is prepared like this: in every 100g mixing fine powders, add refined honey 40～60g, mix, in steam pressure, be that 0.40～0.60Mpa, baking temperature are dry under 45～80 ℃, the condition of moisture≤12.0%, be prepared into condensed water honeyed pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113546049A (en) * | 2021-04-30 | 2021-10-26 | 贵州汉方药业有限公司 | Flexible pill medicine adhesive and flexible pill prepared by using same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723986A (en) * | 2005-06-10 | 2006-01-25 | 湖南麓山天然植物制药有限公司 | Effervescent tablets contg. Astragalus root and fructus ligustric lucidi for strengthening the body resistance, and its prepn. art |
| CN1872180A (en) * | 2006-04-11 | 2006-12-06 | 广西玉林方特药业有限责任公司 | Medication of membranous milk vetch for activating blood and the channels, and preparation method |
| CN101129642A (en) * | 2007-07-16 | 2008-02-27 | 太极集团重庆中药二厂 | Method of preparing concentrated pill of six ingredients with rehmannia |
-
2013
- 2013-12-09 CN CN201310658896.8A patent/CN103655727A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723986A (en) * | 2005-06-10 | 2006-01-25 | 湖南麓山天然植物制药有限公司 | Effervescent tablets contg. Astragalus root and fructus ligustric lucidi for strengthening the body resistance, and its prepn. art |
| CN1872180A (en) * | 2006-04-11 | 2006-12-06 | 广西玉林方特药业有限责任公司 | Medication of membranous milk vetch for activating blood and the channels, and preparation method |
| CN101129642A (en) * | 2007-07-16 | 2008-02-27 | 太极集团重庆中药二厂 | Method of preparing concentrated pill of six ingredients with rehmannia |
Non-Patent Citations (2)
| Title |
|---|
| 王秀良等: "不同赋形剂及配方对中药喷雾干燥浸膏粉制粒的影响", 《中成药》 * |
| 蔡伟庆: "中药颗粒剂辅料的研究进展", 《黑龙江医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113546049A (en) * | 2021-04-30 | 2021-10-26 | 贵州汉方药业有限公司 | Flexible pill medicine adhesive and flexible pill prepared by using same |
| CN113546049B (en) * | 2021-04-30 | 2023-03-17 | 贵州汉方药业有限公司 | Flexible pill medicine adhesive and flexible pill prepared by using same |
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Application publication date: 20140326 |