CN103520420A - Sixiao pill and preparation method thereof - Google Patents
Sixiao pill and preparation method thereof Download PDFInfo
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- CN103520420A CN103520420A CN201310473295.XA CN201310473295A CN103520420A CN 103520420 A CN103520420 A CN 103520420A CN 201310473295 A CN201310473295 A CN 201310473295A CN 103520420 A CN103520420 A CN 103520420A
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Abstract
The invention relates to a Sixiao pill and a preparation method thereof. The Sixiao pill comprises seven effective components. The preparation method is as follows: A, crushing wine fried rhubarb and fried semen pharbitidis into a 100 mesh powder, crushing the stings of fructus gleditsiae, vinegar fried rhizoma cyperi and vinegar fried trogopterus dung into a 120-150 mesh powder, and mixing these two powders; B, distilling Betel with steam, extracting volatile oil, decoction the dregs with semen pharbitidis, filtering and concentrating the obtained decoction, adding alcohol, stirring, taking a supernatant, and concentrating to obtain a viscous substance; and C, mixing the mixed powder from the step A and the viscous substance from the step B, adding water and stirring, and spraying Betel volatile oil to prepare particles; pressing the particles into a ball mould in a spherical mold; and processing the ball mold into the Sixiao pill. The pill prepared by the method provided by the invention is easy for moulding, has smooth surface and ensures the microbial limit to meet the provisions; in addition, the method has short production period and high production efficiency.
Description
Technical field
The present invention relates to the preparation technology of a kind of medicine pill in the field of Chinese medicines, be specifically related to a kind of four balls and preparation method thereof that disappear.
Background technology
Four balls that disappear have dyspepsia and intestinal stasis relieving, and the effect of circulation of qi promoting removing water retention by purgation, is mainly used in treating food stagnation phlegm retention, dyspepsia, distension and fullness in the abdomen, belch acid regurgitation and constipation etc., are the conventional good medicine for the treatment of gastrointestinal disease.Medicine pill is a kind of traditional form of Chinese drug, at Chinese field of medicaments, occupies very large market.At present of common occurrence about four disappear preparation technology's the researchs of ball.
Tradition preparation four techniques that disappear ball are that prescription medical material is ground into 80-100 object fine powder; Part fine powder is added in general ball pot, the piller that adds the certain particle diameter of the general one-tenth of water, with standard screen, piller is screened, select particle diameter piller close to each other, after dry, as mould, then mould is added in general ball pot, all the other medicated powder are evenly sprinkling upon on mould to the general pill of making gradually, adopt the oven for drying pill of hot air circulation, adopt and select ball machine to select prescribed level, ball pill heavily.
The defect of tradition pill: (1), because fibroid pulverizing medicinal materials is not thorough, affects pill molding; Effective ingredient stripping is low, and impact absorbs and curative effect; (2) the mould size of general ball is inhomogeneous, affects shape, the outward appearance of finished product pill, and ball is heavy can not meet pharmacopeia requirement; (3) production efficiency is lower, is per hourly no more than 10,000; Batch production cycle is long, generally need to be at 10-15 days; (4) dissolve scattered time limit of pill is long, conventionally approaches 60 or over 60 minutes; (5) bioavailability of pill is low, and microbial limit can not meet pharmacopeia requirement; (6) poor, the coatings of the fineness of finished product pill has obscission, and the ball method of double differences is different large.
Summary of the invention
The object of this invention is to provide a kind of four balls and preparation method thereof that disappear, prepared four disappear, and ball stripping is high, dissolve scattered time limit is short, bioavailability is high, and its there is good absorbing, curative effect is fast, with short production cycle and efficiency is high; Traditional numerous deficiencies of preparing Chinese medicine pill have been overcome.
The object of the invention is to be achieved through the following technical solutions:
A kind of four balls that disappear, described four disappear ball by seven kinds of effective component contents, and the ratio of various compositions is: Semen Arecae 100～300g, Radix et Rhizoma Rhei (parched with wine) 200～600g, Semen Pharbitidis (parched) 200～400g, Semen Pharbitidis 80～150, Fructus Gleditsiae Abnormalis 25～75g, vinegar are fried Rhizoma Cyperi 100～300g, Oletum Trogopterori (parched with vinegar) 100～200g.
Further, the ratio of kind composition is: Semen Arecae 200g, Radix et Rhizoma Rhei (parched with wine) 400g, Semen Pharbitidis 100g, Semen Pharbitidis (parched) 300g, Fructus Gleditsiae Abnormalis 50g, vinegar are fried Rhizoma Cyperi 200g, Oletum Trogopterori (parched with vinegar) 200g.
A kind of four preparation methoies that disappear ball comprise the following steps:
A is 100 object powder by described Radix et Rhizoma Rhei (parched with wine) 400g and Semen Pharbitidis (parched) 300g pulverizing; By described Fructus Gleditsiae Abnormalis 50g, vinegar stir-fry Rhizoma Cyperi 200g and Oletum Trogopterori (parched with vinegar) 200g pulverizing, be 120～150 object powder again; And by this two classes powder mix homogeneously;
B extracts volatile oil by the Semen Arecae of described 200g with vapor distillation, aqueous solution after medicinal residues and distillation decocts twice with the Semen Pharbitidis of 100g again, gained decocting liquid filters, filtrate is carried out concentrating under reduced pressure, in concentrated later material, add ethanol stirring and dissolving, get supernatant, precipitation continues to add dissolve with ethanol 1～2 time and gets supernatant, above-mentioned supernatant is merged, at relatively low temperature, concentrate to obtain thick material;
C, by the thick material mix homogeneously described in the powder of the mix homogeneously described in A and B, adds deionized water and stirs, and in the time of stirring, spray adds the volatile oil of above-mentioned Semen Arecae, and making particle diameter is 16～18 object granules, dry;
D. the dried granule described in C is put into spherical module and suppress, obtain spherical mold; Spherical mold adds general ball pot pterygium in inner canthus to make the pill that regulation ball is heavy again, after dry described four pills that disappear ball.
Further, the baking temperature described in step C is 50～60 ℃, and be 12～16min drying time.
Further, the baking temperature described in step D is 65～78 ℃, and be 7～11min drying time.
Further, four of the gained pills that disappear ball are carried out to coating, obtain finished product four ball that disappears.
Further, the ethanol that the ethanol described in step B is 60%.
Beneficial effect of the present invention: the invention provides a kind of four balls and preparation method thereof that disappear, compare with traditional preparation technology, this Chinese medicine pill and preparation technology thereof have following advantage:
(1) provided by the invention four disappear each composition ratios of ball are reasonable, and therapeutic effect is good;
(2) pill molding of the present invention is easy, any surface finish;
(3) the present invention adopts the method for granulation, compacting pill mould, general pharmacy ball, overcome traditional general overlong time processed, amount of water excessive, the lymphatic temperament in medicated powder is oozed out, cause the longer shortcoming of dissolve scattered time limit, reduced the dissolve scattered time limit of pill, be conventionally no more than 20 minutes;
(4) pill whole process using of the present invention automated production, has reduced pollution, and the dry effectively killing microorganisms of quick high-temp, guarantees that microbial limit is up to specification;
(5) pill mould of the present invention size evenly, particle diameter can be set by compacting tool set, and the shape of finished product pill, ball weight average meet the requirements, and the ball method of double differences is different in ± 5%;
(6) the present invention is with short production cycle, and every batch of production cycle is within 5 days; Production efficiency is high, ten thousand/hour of 10-30.
The specific embodiment
The embodiment of the present invention has been announced a kind of four balls and preparation method thereof that disappear, this four disappears ball by seven kinds of effective component contents, the ratio of various compositions is: Semen Arecae 100～300g, Radix et Rhizoma Rhei (parched with wine) 200～600g, Semen Pharbitidis (parched) 200～400g, Semen Pharbitidis 80～150g, Fructus Gleditsiae Abnormalis 25～75g, vinegar are fried Rhizoma Cyperi 100～300g, Oletum Trogopterori (parched with vinegar) 100～200g, and preferably Semen Arecae 200g, Radix et Rhizoma Rhei (parched with wine) 400g, Semen Pharbitidis 100g, Semen Pharbitidis (parched) 300g, Fructus Gleditsiae Abnormalis 50g, vinegar are fried Rhizoma Cyperi 200g, Oletum Trogopterori (parched with vinegar) 200g.
This four preparation method that disappears ball comprises the following steps:
A is 100 object powder by described Radix et Rhizoma Rhei (parched with wine) 400g and Semen Pharbitidis (parched) 300g pulverizing; By described Fructus Gleditsiae Abnormalis 50g, vinegar stir-fry Rhizoma Cyperi 200g and Oletum Trogopterori (parched with vinegar) 200g pulverizing, be 120～150 object powder again; And by this two classes powder mix homogeneously;
B extracts volatile oil by the Semen Arecae of described 200g with vapor distillation, aqueous solution after medicinal residues and distillation decocts twice with the Semen Pharbitidis of 100g again, gained decocting liquid filters, and filtrate is carried out concentrating under reduced pressure, in concentrated later material, adds ethanol stirring and dissolving, get supernatant, precipitation continues to add dissolve with ethanol 1～2 time and gets supernatant, preferably 2 times, above-mentioned supernatant is merged, at relatively low temperature, concentrate to obtain thick material, ethanol is herein 60% ethanol preferably;
C is by the thick material mix homogeneously described in the powder of the mix homogeneously described in A and B, add deionized water and stir, when stirring, spray adds the volatile oil of above-mentioned Semen Arecae, making particle diameter is 16～18 object granules, preferred 17 orders, dry 12～16min at 50～60 ℃, preferably dry 15min at 55 ℃;
D. the dried granule described in C is put into spherical module and suppress, obtain spherical mold; Spherical mold adds general ball pot pterygium in inner canthus to make the pill that regulation ball is heavy again, at 65～78 ℃ after dry 7～11min described four pills that disappear ball, preferred dry 8min at 74 ℃ herein
E. four of the gained pills that disappear ball are carried out to coating, obtain finished product four ball that disappears.
With specific embodiment, be illustrated the specific embodiment of the present invention below, should be appreciated that specific embodiment described herein, only in order to the present invention that explains, is not intended to limit the present invention.
Embodiment 1
Take Radix et Rhizoma Rhei (parched with wine) 400g and Semen Pharbitidis (parched) 300g, be crushed into 100 object powder; Taking Fructus Gleditsiae Abnormalis 50g, vinegar stir-fry Rhizoma Cyperi 200g and Oletum Trogopterori (parched with vinegar) 200g pulverizing is 120～150 object powder again; And by this two classes powder mix homogeneously;
Take the Semen Arecae of 200g and extract volatile oil with vapor distillation, aqueous solution after medicinal residues and distillation decocts twice with the Semen Pharbitidis of 100g again, gained decocting liquid filters, filtrate is carried out concentrating under reduced pressure, in concentrated later material, add 60% ethanol stirring and dissolving, get supernatant, precipitation continues add 60% twice of dissolve with ethanol and get supernatant, above-mentioned supernatant is merged, concentrate to obtain thick material;
By the powder of above-mentioned mix homogeneously and thick material mix homogeneously, add deionized water and stir, in the time of stirring, spray adds the volatile oil of above-mentioned Semen Arecae, and making particle diameter is 17 object granules, dry 15min at 55 ℃; This dried granule is put into spherical module and suppress, obtain spherical mold; Spherical mold adds general ball pot pterygium in inner canthus to make the pill that regulation ball is heavy again, at 74 ℃ after dry 8min four pills that disappear ball; Four of the gained pills that disappear ball are carried out to coating, obtain finished product four ball that disappears.
Embodiment 2
Take Radix et Rhizoma Rhei (parched with wine) 400g and Semen Pharbitidis (parched) 300g, be crushed into 100 object powder; Taking Fructus Gleditsiae Abnormalis 50g, vinegar stir-fry Rhizoma Cyperi 200g and Oletum Trogopterori (parched with vinegar) 200g pulverizing is 120～150 object powder again; And by this two classes powder mix homogeneously;
Take the Semen Arecae of 200g and extract volatile oil with vapor distillation, aqueous solution after medicinal residues and distillation decocts twice with the Semen Pharbitidis of 100g again, gained decocting liquid filters, filtrate is carried out concentrating under reduced pressure, in concentrated later material, add 60% ethanol stirring and dissolving, get supernatant, precipitation continues add 60% twice of dissolve with ethanol and get supernatant, above-mentioned supernatant is merged, concentrate to obtain thick material;
By the powder of above-mentioned mix homogeneously and thick material mix homogeneously, add deionized water and stir, in the time of stirring, spray adds the volatile oil of above-mentioned Semen Arecae, and making particle diameter is 18 object granules, dry 16min at 52 ℃; This dried granule is put into spherical module and suppress, obtain spherical mold; Spherical mold adds general ball pot pterygium in inner canthus to make the pill that regulation ball is heavy again, at 70 ℃ after dry 10min four pills that disappear ball; Four of the gained pills that disappear ball are carried out to coating, obtain finished product four ball that disappears.
The present invention is not limited to above-mentioned preferred forms, any modification relevant of the present invention or change that anyone does under enlightenment of the present invention, and every have identical with a application or akin technical scheme, within all dropping on protection scope of the present invention.
Claims (7)
1. the ball that disappears, described four disappear ball by seven kinds of effective component contents, it is characterized in that: the ratio of various compositions is: Semen Arecae 100～300g, Radix et Rhizoma Rhei (parched with wine) 200～600g, Semen Pharbitidis (parched) 200～400g, Semen Pharbitidis 80～150g, Fructus Gleditsiae Abnormalis 25～75g, vinegar are fried Rhizoma Cyperi 100～300g, Oletum Trogopterori (parched with vinegar) 100～200g.
2. according to claim 1 four balls that disappear, is characterized in that: four ratios that disappear the various compositions of ball are: Semen Arecae 200g, Radix et Rhizoma Rhei (parched with wine) 400g, Semen Pharbitidis 100g, Semen Pharbitidis (parched) 300g, Fructus Gleditsiae Abnormalis 50g, vinegar are fried Rhizoma Cyperi 200g, Oletum Trogopterori (parched with vinegar) 200g.
3. according to claim 2 four preparation methoies that disappear ball, is characterized in that: described preparation method comprises the following steps:
A is 100 object powder by described Radix et Rhizoma Rhei (parched with wine) 400g and Semen Pharbitidis (parched) 300g pulverizing; By described Fructus Gleditsiae Abnormalis 50g, vinegar stir-fry Rhizoma Cyperi 200g and Oletum Trogopterori (parched with vinegar) 200g pulverizing, be 120～150 object powder again; And by this two classes powder mix homogeneously;
B extracts volatile oil by the Semen Arecae of described 200g with vapor distillation, aqueous solution after medicinal residues and distillation decocts twice with the Semen Pharbitidis of 100g again, gained decocting liquid filters, filtrate is carried out concentrating under reduced pressure, in concentrated later material, add ethanol stirring and dissolving, get supernatant, precipitation continues to add dissolve with ethanol 1～2 time and gets supernatant, above-mentioned supernatant is merged, concentrate to obtain thick material;
C, by the thick material mix homogeneously described in the powder of the mix homogeneously described in A and B, adds deionized water and stirs, and in the time of stirring, spray adds the volatile oil of above-mentioned Semen Arecae, and making particle diameter is 16～18 object granules, dry;
D. the dried granule described in C is put into spherical module and suppress, obtain spherical mold; Spherical mold adds general ball pot pterygium in inner canthus to make the pill that regulation ball is heavy again, after dry described four pills that disappear ball.
4. according to claim 3 four preparation methoies that disappear ball, is characterized in that: the baking temperature described in step C is 50～60 ℃, and be 12～16min drying time.
5. according to claim 3 four preparation methoies that disappear ball, is characterized in that: the baking temperature described in step D is 65～78 ℃, and be 7～11min drying time.
6. according to claim 3 four preparation methoies that disappear ball, is characterized in that: four of the gained pills that disappear ball are carried out to coating, obtain finished product four ball that disappears.
7. according to claim 3 four preparation methoies that disappear ball, is characterized in that: the ethanol that the ethanol described in step B is 60%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310473295.XA CN103520420A (en) | 2013-10-12 | 2013-10-12 | Sixiao pill and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310473295.XA CN103520420A (en) | 2013-10-12 | 2013-10-12 | Sixiao pill and preparation method thereof |
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| CN103520420A true CN103520420A (en) | 2014-01-22 |
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| CN201310473295.XA Pending CN103520420A (en) | 2013-10-12 | 2013-10-12 | Sixiao pill and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108704098A (en) * | 2018-07-31 | 2018-10-26 | 河南润弘本草制药有限公司 | One kind four disappears ball and preparation method thereof |
| CN110507743A (en) * | 2019-09-06 | 2019-11-29 | 山西正元盛邦制药有限公司 | One kind helps digestion stagnant gas ball preparation process |
-
2013
- 2013-10-12 CN CN201310473295.XA patent/CN103520420A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108704098A (en) * | 2018-07-31 | 2018-10-26 | 河南润弘本草制药有限公司 | One kind four disappears ball and preparation method thereof |
| CN110507743A (en) * | 2019-09-06 | 2019-11-29 | 山西正元盛邦制药有限公司 | One kind helps digestion stagnant gas ball preparation process |
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Application publication date: 20140122 |
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| WD01 | Invention patent application deemed withdrawn after publication |