CN103494952A - Wuzi Yanzong pill and preparation process thereof - Google Patents
Wuzi Yanzong pill and preparation process thereof Download PDFInfo
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- CN103494952A CN103494952A CN201310473331.2A CN201310473331A CN103494952A CN 103494952 A CN103494952 A CN 103494952A CN 201310473331 A CN201310473331 A CN 201310473331A CN 103494952 A CN103494952 A CN 103494952A
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Abstract
The invention relates to a Wuzi Yanzong pill and a preparation method thereof. The Wuzi Yanzong pill comprises the following components in percentage by mass: 35 percent of barbary wolfberry fruit, 34.5 percent of fried semen cuscutae, 17 percent of raspberry, 4.5 percent of steamed Chinese magnoliavine fruit and 9 percent of salt-fried semen plantaginis. The preparation method comprises the following steps of crushing, particle preparation, pressing and pill preparation. In the crushing process, the barbary wolfberry fruit, the fried semen cuscutae and the raspberry are crushed into powder of 60-80 meshes, the steamed Chinese magnoliavine fruit and the salt-fried semen plantaginis are crushed into powder of 140-150 meshes, and the powders are uniformly mixed to form fine raw powder; in the particle preparation process, an aqueous solution containing refined honey is added in the fine raw powder to prepare particles of 20 meshes; in the pressing process, the particles are put into a spherical mold and pressed to form a spherical model; in the pill preparation process, the spherical model is put into a pill processing pot and processed to form the Wuzi Yanzong pill. A preparation process of the Wuzi Yanzong pill is short in production peroid and high in production efficiency; the prepared Wuzi Yanzong pill is easy to mold, has a smooth surface and ensures that the microbial limit meets the specification.
Description
Technical field
The present invention relates to a kind of preparation technology of medicine pill, be specifically related to a kind of WUZIYANZONG WAN and preparation technology thereof.
Background technology
Pill is a kind of important Chinese medicine dosage form, and WUZIYANZONG WAN is a kind of time-honored Chinese medicine, and it originates from the Tang Dynasty, Fructus Lycii, Semen Cuscutae, Fructus Rubi, Fructus Schisandrae Chinensis and Semen Plantaginis, consists of, and is described as at all times " seed first party ".Wherein, Fructus Lycii and Semen Cuscutae can the kidney invigorating, and Fructus Rubi is used for growing essence, and Fructus Schisandrae Chinensis can be enriched blood, and Semen Plantaginis diuresis controlling nocturnal emission with astringent drugs, so WUZIYANZONG WAN has numerous effects such as resisting fatigue, the kidney invigorating and essence nourishing, is clinical important drugs.Also be subject to through the ages much favors of medicines and medicine technical study person therefore study its different preparation method.
The WUZIYANZONG WAN traditional handicraft is that the prescription medical material is ground into to 80-100 purpose fine powder; The part fine powder is added in general ball pot, piller with the certain particle diameter of the general one-tenth of mulse, with standard screen, piller is screened, select particle diameter piller close to each other, as mould, then mould is added in general ball pot after drying, all the other medicated powder evenly are sprinkling upon on mould to the general pill of making gradually, adopt the oven for drying pill of hot air circulation, adopt and select the ball machine to select prescribed level, ball pill heavily.
The defect of tradition pill: 1), because the fibroid pulverizing medicinal materials is not thorough, affect the pill molding; The effective ingredient stripping is low, and impact absorbs and curative effect; 2) the mould size of general ball is inhomogeneous, affects shape, the outward appearance of finished product pill, and ball is heavy can not meet the pharmacopeia requirement; 3) production efficiency is lower, per hour is no more than 10,000; Batch production cycle is long; 4) dissolve scattered time limit of pill is long, generally over 60 minutes; 5) bioavailability of pill is low, and microbial limit can not meet the pharmacopeia requirement; 6) poor, the coatings of the fineness of finished product pill has obscission, and the ball method of double differences is different large.
Summary of the invention
The purpose of this invention is to provide a kind of WUZIYANZONG WAN and preparation technology thereof, the various composition ratios of this WUZIYANZONG WAN are reasonable, the pill stripping prepared by this technique is high, dissolve scattered time limit is short, bioavailability is high, and its there is good absorbing, curative effect is fast, with short production cycle and efficiency is high; Traditional numerous deficiencies that prepare Chinese medicine pill have been overcome.
The objective of the invention is to be achieved through the following technical solutions:
A kind of WUZIYANZONG WAN, the active ingredient of described WUZIYANZONG WAN and the mass percent of various compositions are: Fructus Lycii 35%, Semen Cuscutae (parched) 34.5%, Fructus Rubi 17%, Fructus Schisandrae Chinensis (steamed) 4.5%, Semen Plantaginis (parched with salt) 9%.
A kind of preparation technology of WUZIYANZONG WAN, described preparation technology comprises pulverizing, prepares granule, compacting and pill preparation;
1. described pulverizing is that the Fructus Rubi of described 35% Fructus Lycii, 34.5% Semen Cuscutae (parched) and 17% is pulverized is 60～80 purpose powder; It is 140～150 purpose powder that Fructus Schisandrae Chinensis (steamed) by described 4.5% and 9% Semen Plantaginis (parched with salt) are pulverized, and, by the powder mix homogeneously of these five kinds of Chinese herbal medicine, is raw material fine powder.
2. the described granule for preparing is to add aqueous solution in described raw material fine powder, and stirring and making particle diameter is 20 purpose granules, drying.
3. described compacting is the dried granule described in 2. to be put into to spherical module suppressed, and makes spherical mold.
4. described pill preparation is that spherical mold is put in general ball pot, and adds gradually the general regulation ball pill heavily of making of raw material fine powder, obtains the pill of WUZIYANZONG WAN after drying.
Further, be added with refined honey in the aqueous solution described in 2..
Further, the amount of described refined honey is 30～40% of raw material fine powder amount.
Further, the amount of described refined honey is 37% of raw material fine powder amount.
Further, step 2. and the drying 4. under 70～75 ℃, carry out.
Further, described pill carries out coating and makes the WUZIYANZONG WAN finished product.
Beneficial effect of the present invention: the invention provides a kind of WUZIYANZONG WAN and preparation technology thereof, compare with traditional preparation technology, this Chinese medicine pill and preparation technology thereof have following advantage:
1. each composition ratio of WUZIYANZONG WAN provided by the invention is reasonable, and therapeutic effect is good;
2. pill molding of the present invention is easy, any surface finish;
3. the present invention adopts the method for granulation, compacting pill mould, general pharmacy ball, overcome traditional general overlong time processed, amount of water excessive, the lymphatic temperament in medicated powder is oozed out, cause the longer shortcoming of dissolve scattered time limit, reduced the dissolve scattered time limit of pill, usually be no more than 20 minutes;
4. pill whole process using of the present invention automated production, reduced pollution, and the quick high-temp drying is killing microorganisms effectively, guarantees that microbial limit is up to specification;
5. pill mould of the present invention size evenly, particle diameter can be set by compacting tool set, and the shape of finished product pill, ball weight average meet the requirements, and the ball method of double differences is different in ± 5%;
6. the present invention is with short production cycle, and every batch of production cycle is within 5 days; Production efficiency is high, ten thousand/hour of 10-30.
The specific embodiment
The embodiment of the present invention has been announced a kind of WUZIYANZONG WAN and preparation technology thereof, below with specific embodiment, be illustrated the specific embodiment of the present invention, should be appreciated that specific embodiment described herein, only in order to the present invention that explains, is not intended to limit the present invention.
Embodiment 1
Accurately take 35% Fructus Lycii, 34.5% Semen Cuscutae (parched) and 17% Fructus Rubi, and be crushed into 80 purpose powder, mix homogeneously; Accurately take 4.5% Fructus Schisandrae Chinensis (steamed) and 9% Semen Plantaginis (parched with salt) again, be crushed into 150 purpose powder, then the powder of these five kinds of Chinese herbal medicine is stirred, mix homogeneously, be raw material fine powder.
Add the aqueous solution that contains refined honey in this raw material fine powder, the amount of refined honey is 37% of raw material fine powder amount, and stirring and making particle diameter is 20 purpose granules, under 75 ℃ dry 13 minutes; Then this dried granule is put into to spherical module and suppressed, make spherical mold; This spherical mold is put in general ball pot again, and adds gradually that raw material fine powder is general makes the pill that the regulation ball is heavy, dry 15 minutes dryings under 72 ℃, obtain the pill of WUZIYANZONG WAN.This pill is carried out to coating and make the WUZIYANZONG WAN finished product.
Embodiment 2
Accurately take 35% Fructus Lycii, 34.5% Semen Cuscutae (parched) and 17% Fructus Rubi, and be crushed into 70 purpose powder, mix homogeneously; Accurately take 4.5% Fructus Schisandrae Chinensis (steamed) and 9% Semen Plantaginis (parched with salt) again, be crushed into 140 purpose powder, then the powder of these five kinds of Chinese herbal medicine is stirred, mix homogeneously, be raw material fine powder.
Add the aqueous solution that contains refined honey in this raw material fine powder, the amount of refined honey is 35% of raw material fine powder amount, and stirring and making particle diameter is 20 purpose granules, under 70 ℃ dry 18 minutes; Then this dried granule is put into to spherical module and suppressed, make spherical mold; This spherical mold is put in general ball pot again, and adds gradually that raw material fine powder is general makes the pill that the regulation ball is heavy, dry 15 minutes dryings under 73 ℃, obtain the pill of WUZIYANZONG WAN.This pill is carried out to coating and make the WUZIYANZONG WAN finished product.
The present invention is not limited to above-mentioned preferred forms, any modification relevant of the present invention or change that anyone does under enlightenment of the present invention, and every have identical with a application or akin technical scheme, within all dropping on protection scope of the present invention.
Claims (8)
1. a WUZIYANZONG WAN, it is characterized in that: the active ingredient of described WUZIYANZONG WAN and the mass percent of various compositions are: Fructus Lycii 35%, Semen Cuscutae (parched) 34.5%, Fructus Rubi 17%, Fructus Schisandrae Chinensis (steamed) 4.5% and Semen Plantaginis (parched with salt) 9%.
2. the preparation technology of a WUZIYANZONG WAN according to claim 1 is characterized in that: described preparation technology comprises pulverizing, prepares granule, compacting and pill preparation;
Described pulverizing is that the Fructus Rubi of described 35% Fructus Lycii, 34.5% Semen Cuscutae (parched) and 17% is pulverized is 60～80 purpose powder; It is 140～150 purpose powder that Fructus Schisandrae Chinensis (steamed) by described 4.5% and 9% Semen Plantaginis (parched with salt) are pulverized, and, by the powder mix homogeneously of these five kinds of Chinese herbal medicine, is raw material fine powder;
The described granule for preparing is to add aqueous solution in described raw material fine powder, and stirring and making particle diameter is 20 purpose granules, drying;
Described compacting is described dried granule to be put into to spherical module suppressed, and makes spherical mold;
Described pill preparation is that spherical mold is put in general ball pot, and adds gradually the general regulation ball pill heavily of making of raw material fine powder, obtains the pill of WUZIYANZONG WAN after drying.
3. the preparation technology of WUZIYANZONG WAN according to claim 2, is characterized in that: in the aqueous solution 2., be added with refined honey.
4. the preparation technology of WUZIYANZONG WAN according to claim 3, it is characterized in that: the amount of described refined honey is 30～40% of raw material fine powder amount.
5. according to the preparation technology of claim 3 or 4 described WUZIYANZONG WAN, it is characterized in that: the amount of described refined honey is 37% of raw material fine powder amount.
6. the preparation technology of WUZIYANZONG WAN according to claim 2, it is characterized in that: described drying is carried out under 70～75 ℃.
7. according to the preparation technology of claim 2 or 6 described WUZIYANZONG WAN, it is characterized in that: be 13～18 minutes described drying time.
8. the preparation technology of WUZIYANZONG WAN according to claim 2, it is characterized in that: described pill carries out coating and makes the WUZIYANZONG WAN finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310473331.2A CN103494952A (en) | 2013-10-12 | 2013-10-12 | Wuzi Yanzong pill and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310473331.2A CN103494952A (en) | 2013-10-12 | 2013-10-12 | Wuzi Yanzong pill and preparation process thereof |
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| CN103494952A true CN103494952A (en) | 2014-01-08 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015172399A1 (en) * | 2014-05-12 | 2015-11-19 | 四川圣湖生物科技有限公司 | Pharmaceutical composition for improving male sexual dysfunction |
| CN108721435A (en) * | 2018-05-24 | 2018-11-02 | 华南理工大学 | A kind of Semen Cuscutae composite essential oil and the preparation method and application thereof |
| CN111281927A (en) * | 2020-04-17 | 2020-06-16 | 山西中医药大学 | Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof |
-
2013
- 2013-10-12 CN CN201310473331.2A patent/CN103494952A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015172399A1 (en) * | 2014-05-12 | 2015-11-19 | 四川圣湖生物科技有限公司 | Pharmaceutical composition for improving male sexual dysfunction |
| CN108721435A (en) * | 2018-05-24 | 2018-11-02 | 华南理工大学 | A kind of Semen Cuscutae composite essential oil and the preparation method and application thereof |
| CN111281927A (en) * | 2020-04-17 | 2020-06-16 | 山西中医药大学 | Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof |
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Application publication date: 20140108 |
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| WD01 | Invention patent application deemed withdrawn after publication |