CN103479804A - Coptis bolus for clearing upper heat, and preparation method thereof - Google Patents
Coptis bolus for clearing upper heat, and preparation method thereof Download PDFInfo
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- CN103479804A CN103479804A CN201310473335.0A CN201310473335A CN103479804A CN 103479804 A CN103479804 A CN 103479804A CN 201310473335 A CN201310473335 A CN 201310473335A CN 103479804 A CN103479804 A CN 103479804A
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Abstract
The invention relates to a coptis bolus for clearing upper heat, and a preparation method thereof. Components of the coptis bolus for clearing upper heat comprise coptis, ginger processed Fructus Gardeniae, Weeping Forsythia, stir-fried Fructus Viticis, Divaricate Saposhnikovia Root, spikes of Herba Schizonepetae, dahurian angelica root, Radix Scutellariae, chrysanthemum, mint, prepared Radix et Rhizoma Rhei with wine, wine fried Amur Corktree Bark, Radix Platycodonis, Ligusticum wallichii, gypsum, Flos Inulae and licorice root. The preparation method of the coptis bolus for clearing upper heat mainly comprises the following steps: 1, crushing above components composing the coptis bolus for clearing upper heat to prepare 130-150 mesh fine powder; 2, adding deionized water to the fine powder to prepare particles having a particle size of 20 meshes; 3, putting the particles in a spherical die, and pressing to obtain a spherical model; and 4, adding the spherical model to a processing pot, adding the fine powder to prepare a bolus having a prescribed weight, and drying to obtain the coptis bolus for clearing upper heat. The component proportions of the coptis bolus for clearing upper heat are reasonable. The coptis bolus prepared by adopting the method is easy to mold, has a clean surface, and ensures that the microbial limit accords with the prescription; and additionally, the method has the advantages of short production period and high production efficiency.
Description
Technical field
The present invention relates to prepare the Chinese medicine pill field, be specifically related to a kind of coptos bolus for clearing the upper heat and preparation method thereof.
Background technology
Pill is a kind of Chinese medicine dosage form, at Chinese field of medicaments, occupies very large market; And coptos bolus for clearing the upper heat is a kind of important Chinese herbal medicine, for most of Chinese common people, it is all the standing domestic medicine that what's frequently heard can be repeated in detail, the function that it has loose wind heat clearing away, pathogenic fire purging pain relieving, be mainly used in attacking on wind heat, having a dizzy spell due to exuberant lung-stomach heat, dental pain, aphtha of the mouth and tongue, laryngopharynx swelling and pain, otalgia tinnitus, constipation and oliguria with reddish urine etc.Preparation technology about coptos bolus for clearing the upper heat also comes into one's own.
The traditional handicraft of coptos bolus for clearing the upper heat is that the prescription medical material is ground into to 80-100 purpose fine powder; The part fine powder is added in general ball pot, the piller that adds the certain particle diameter of the general one-tenth of water, with standard screen, piller is screened, select particle diameter piller close to each other, as mould, then mould is added in general ball pot after drying, all the other medicated powder evenly are sprinkling upon on mould to the general pill of making gradually, adopt the oven for drying pill of hot air circulation, adopt and select the ball machine to select prescribed level, ball pill heavily.
The defect of tradition pill: (1), because the fibroid pulverizing medicinal materials is not thorough, affects the pill molding; The effective ingredient stripping is low, and impact absorbs and curative effect; (2) the mould size of general ball is inhomogeneous, affects shape, the outward appearance of finished product pill, and ball is heavy can not meet the pharmacopeia requirement; (3) production efficiency is lower, per hour is no more than 10,000; Batch production cycle is long, generally need to be at 10-15 days; (4) dissolve scattered time limit of pill is long, usually approaches 60 or over 60 minutes; (5) bioavailability of pill is low, and microbial limit can not meet the pharmacopeia requirement; (6) poor, the coatings of the fineness of finished product pill has obscission, and the ball method of double differences is different large.
Summary of the invention
The purpose of this invention is to provide a kind of coptos bolus for clearing the upper heat and preparation method thereof, prepared pill stripping is high, dissolve scattered time limit is short, bioavailability is high, and its there is good absorbing, curative effect is fast, with short production cycle and efficiency is high; Traditional numerous deficiencies that prepare Chinese medicine pill have been overcome.
The objective of the invention is to be achieved through the following technical solutions:
A kind of coptos bolus for clearing the upper heat, each composition of described coptos bolus for clearing the upper heat is Chinese herbal medicine, and its mass percent is: Rhizoma Coptidis 0.8%, processed with Rhizoma Zingiberis Recens Fructus Gardeniae 6.2%, Fructus Forsythiae 6%, stir-baked FRUCTUS VITICIS 6.2%, Radix Saposhnikoviae 3%, Herba Schizonepetae 5.8%, the Radix Angelicae Dahuricae 6.6%, Radix Scutellariae 6%, Flos Chrysanthemi 12.8%, Herba Menthae 3.2%, Radix et Rhizoma Rhei (stir-fried with wine) 23%, wine Cortex Phellodendri (parched) 3.1%, Radix Platycodonis 6.1%, Rhizoma Chuanxiong 3.2%, Gypsum Fibrosum 3.1%, Flos Inulae 1.4% and Radix Glycyrrhizae 3.5%.
Described preparation method comprises the following steps:
(1) the various Chinese herbal medicine medical materials that will form described coptos bolus for clearing the upper heat are pulverized, and cross 130～150 mesh sieves, and the gained fine powder is standby; 130～150 mesh sieves are pulverized and crossed to the gained coarse powder again, merges the gained fine powder;
(2) add deionized water to the fine powder described in (1), stir, making particle diameter is 20 purpose granules, dry described granule;
(3) the dried granule described in (2) is put into to spherical module and suppressed, obtain spherical mold;
(4) spherical mold described in (3) is added in general ball pot, and add the general regulation ball pill heavily of making of fine powder, obtain described coptos bolus for clearing the upper heat after drying.
Further, described baking temperature is 68～78 ℃, and be 15～20min drying time.
Further, the coptos bolus for clearing the upper heat coated pill by gained, obtain the coptos bolus for clearing the upper heat finished product.
Beneficial effect of the present invention: the invention provides a kind of coptos bolus for clearing the upper heat and preparation method thereof, compare with traditional preparation technology, this Chinese medicine pill and preparation technology thereof have following advantage:
(1) each composition ratio of coptos bolus for clearing the upper heat provided by the invention is reasonable, and therapeutic effect is good;
(2) pill molding of the present invention is easy, any surface finish;
(3) the present invention adopts the method for granulation, compacting pill mould, general pharmacy ball, overcome traditional general overlong time processed, amount of water excessive, the lymphatic temperament in medicated powder is oozed out, cause the longer shortcoming of dissolve scattered time limit, reduced the dissolve scattered time limit of pill, usually be no more than 20 minutes;
(4) pill whole process using of the present invention automated production, reduced pollution, and the quick high-temp drying is killing microorganisms effectively, guarantees that microbial limit is up to specification;
(5) pill mould of the present invention size evenly, particle diameter can be set by compacting tool set, and the shape of finished product pill, ball weight average meet the requirements, and the ball method of double differences is different in ± 5%;
(6) the present invention is with short production cycle, and every batch of production cycle is within 5 days; Production efficiency is high, ten thousand/hour of 10-30.
The specific embodiment
The embodiment of the present invention has been announced a kind of coptos bolus for clearing the upper heat and preparation method thereof, below with specific embodiment, be illustrated the specific embodiment of the present invention, should be appreciated that specific embodiment described herein, only in order to the present invention that explains, is not intended to limit the present invention.
Embodiment 1
Accurately take 17 kinds of Chinese crude drug compositions of coptos bolus for clearing the upper heat, take 0.8% Rhizoma Coptidis, 6.2% processed with Rhizoma Zingiberis Recens Fructus Gardeniae, 6% Fructus Forsythiae, 6.2% stir-baked FRUCTUS VITICIS, 3% Radix Saposhnikoviae, 5.8% Herba Schizonepetae, 6.6% the Radix Angelicae Dahuricae, 6% Radix Scutellariae, 12.8% Flos Chrysanthemi, 3.2% Herba Menthae, 23% Radix et Rhizoma Rhei (stir-fried with wine), 3.1% wine Cortex Phellodendri (parched), 6.1% Radix Platycodonis, 3.2% Rhizoma Chuanxiong, 3.1% Gypsum Fibrosum, 1.4% Flos Inulae and 3.5% Radix Glycyrrhizae, by its pulverizing, cross 140 mesh sieves, the gained fine powder is standby; The gained coarse powder pulverized again and crossed 140 mesh sieves, being merged the fine powder of twice gained.
Fine powder to gained adds deionized water, stirs, and making particle diameter is 20 purpose granules, dry this granule under 78 ℃, and be 15 minutes drying time; Then dried granule is put into to spherical module and suppressed, obtain spherical mold; This spherical mold is added in general ball pot again, and add the general regulation ball pill heavily of making of fine powder, obtain described coptos bolus for clearing the upper heat after drying under 78 ℃, be 15 minutes drying time; In this coptos bolus for clearing the upper heat coated pill, obtain the coptos bolus for clearing the upper heat finished product.
Embodiment 2
Accurately take 17 kinds of Chinese crude drug compositions of coptos bolus for clearing the upper heat, take 0.8% Rhizoma Coptidis, 6.2% processed with Rhizoma Zingiberis Recens Fructus Gardeniae, 6% Fructus Forsythiae, 6.2% stir-baked FRUCTUS VITICIS, 3% Radix Saposhnikoviae, 5.8% Herba Schizonepetae, 6.6% the Radix Angelicae Dahuricae, 6% Radix Scutellariae, 12.8% Flos Chrysanthemi, 3.2% Herba Menthae, 23% Radix et Rhizoma Rhei (stir-fried with wine), 3.1% wine Cortex Phellodendri (parched), 6.1% Radix Platycodonis, 3.2% Rhizoma Chuanxiong, 3.1% Gypsum Fibrosum, 1.4% Flos Inulae and 3.5% Radix Glycyrrhizae, by its pulverizing, cross 150 mesh sieves, the gained fine powder is standby; The gained coarse powder pulverized again and crossed 150 mesh sieves, being merged the fine powder of twice gained.
Fine powder to gained adds deionized water, stirs, and making particle diameter is 20 purpose granules, dry this granule under 68 ℃, and be 20 minutes drying time; Then dried granule is put into to spherical module and suppressed, obtain spherical mold; This spherical mold is added in general ball pot again, and add the general regulation ball pill heavily of making of fine powder, obtain described coptos bolus for clearing the upper heat after drying under 68 ℃, be 20 minutes drying time; In this coptos bolus for clearing the upper heat coated pill, obtain the coptos bolus for clearing the upper heat finished product.
The present invention is not limited to above-mentioned preferred forms, any modification relevant of the present invention or change that anyone does under enlightenment of the present invention, and every have identical with a application or akin technical scheme, within all dropping on protection scope of the present invention.
Claims (4)
1. a coptos bolus for clearing the upper heat, each composition of described coptos bolus for clearing the upper heat is Chinese herbal medicine, it is characterized in that: its mass percent is: Rhizoma Coptidis 0.8%, processed with Rhizoma Zingiberis Recens Fructus Gardeniae 6.2%, Fructus Forsythiae 6%, stir-baked FRUCTUS VITICIS 6.2%, Radix Saposhnikoviae 3%, Herba Schizonepetae 5.8%, the Radix Angelicae Dahuricae 6.6%, Radix Scutellariae 6%, Flos Chrysanthemi 12.8%, Herba Menthae 3.2%, Radix et Rhizoma Rhei (stir-fried with wine) 23%, wine Cortex Phellodendri (parched) 3.1%, Radix Platycodonis 6.1%, Rhizoma Chuanxiong 3.2%, Gypsum Fibrosum 3.1%, Flos Inulae 1.4% and Radix Glycyrrhizae 3.5%.
2. the preparation method of a coptos bolus for clearing the upper heat according to claim 1, it is characterized in that: described preparation method comprises the following steps:
(1) the various Chinese herbal medicine medical materials that will form described coptos bolus for clearing the upper heat are pulverized, and cross 130～150 mesh sieves, and the gained fine powder is standby; 130～150 mesh sieves are pulverized and crossed to the gained coarse powder again, merges the gained fine powder;
(2) add deionized water to the fine powder described in (1), stir, making particle diameter is 20 purpose granules, dry described granule;
(3) the dried granule described in (2) is put into to spherical module and suppressed, obtain spherical mold;
(4) spherical mold described in (3) is added in general ball pot, and add the general regulation ball pill heavily of making of fine powder, obtain described coptos bolus for clearing the upper heat after drying.
3. the preparation method of coptos bolus for clearing the upper heat according to claim 2, it is characterized in that: described baking temperature is 68～78 ℃, be 15～20min drying time.
4. the preparation method of coptos bolus for clearing the upper heat according to claim 2, it is characterized in that: the coptos bolus for clearing the upper heat coated pill by gained obtains the coptos bolus for clearing the upper heat finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822755A (en) * | 2017-01-12 | 2017-06-13 | 张超英 | One kind is relieved the effect of alcohol guttural tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822755A (en) * | 2017-01-12 | 2017-06-13 | 张超英 | One kind is relieved the effect of alcohol guttural tablets and preparation method thereof |
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Application publication date: 20140101 |