CN1709364A - Chinese medicine formulation for expelling heat to alleviate pain, and its preparing method - Google Patents
Chinese medicine formulation for expelling heat to alleviate pain, and its preparing method Download PDFInfo
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Abstract
The present invention discloses a Chinese medicine preparation Huanglian Shangqing dripping pills or dispersing tablet with the functions of dissipating wind, clearing away heat, purging the pathogenic fire and stopping pain and its preparation method. Said Chinese medicine preparation can be made up by using 17 Chinese medicinal materials of coptis root, gardenia fruit, forsythia fruit, stir-fried vitex fruit, ledebouriella root, schizonepeta spike and others, and can be made into dripping pills or dispersing tablet. Besides, said invention also provides the concrete steps of its preparation method.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of expelling heat to alleviate pain and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or dispersible tablet, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical formulation, and this product has tablet now, has listed the national drug ministry standard in.
The existing technology features that is used for the Chinese medicine preparation Rhizoma Coptidis supernatant sheet of expelling heat to alleviate pain is that prescription Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Gypsum Fibrosum, Rhizoma Coptidis powder are broken into fine powder; Herba Menthae, Fructus Forsythiae, extracting volatile oil from schizonepeta spike, medicinal residues decoct with water, filter and be condensed into thick paste; All the other ten flavor alcohol heating reflux reclaim ethanol, are condensed into thick paste; Medicinal residues decoct with water again, filter to be condensed into thick paste, merge thick paste, are condensed into clear paste, with above-mentioned powder mixing, make granule, and drying sprays into volatile oil, mixing, tabletting.
Shortcomings such as the Chinese medicine preparation Rhizoma Coptidis supernatant sheet of existing expelling heat to alleviate pain exists dose big, and disintegration time is long, bioavailability is low, and quality is wayward.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of expelling heat to alleviate pain and preparation method thereof, overcome the above-mentioned drawback of prior art, improve quality, curative effect, the bioavailability of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of expelling heat to alleviate pain, it is that main component is drop pill or the dispersible tablet of Rhizoma Coptidis, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-fry), Radix Saposhnikoviae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Flos Chrysanthemi, Herba Menthae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Platycodonis, Rhizoma Chuanxiong, Gypsum Fibrosum, Flos Inulae, Radix Glycyrrhizae.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Rhizoma Coptidis 0.5～3%, Herba Menthae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Cortex Phellodendri, Gypsum Fibrosum each 2～6%, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-frys), Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Radix Platycodonis respectively 3～10%, Flos Chrysanthemi 8～15%, Radix Et Rhizoma Rhei 15～30%, Flos Inulae 1～5%;
The optimum weight percentage ratio of medicine constituent is:
Rhizoma Coptidis 0.7%, Herba Menthae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Cortex Phellodendri, Gypsum Fibrosum each 3.05%, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-frys), Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Radix Platycodonis respectively 6.1%, Flos Chrysanthemi 12.4%, Radix Et Rhizoma Rhei 24.4%, Flos Inulae 1.5%.
(2) get Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Gypsum Fibrosum, Rhizoma Coptidis powder and be broken into fine powder, sieve, mixing, standby;
(3) Herba Menthae, Fructus Forsythiae, extracting volatile oil from schizonepeta spike are standby; Medicinal residues are standby;
(4) medicinal residues of getting (3) gained decoct with water 1～3 time, each 1～3 hour, and collecting decoction filters, and filtrate is condensed into thick paste, and is standby;
(5) all the other ten flavor Flos Inulaes etc. were with 60～80% alcohol heating reflux 1～3 hour, and extracting solution recovery ethanol is condensed into thick paste, and is standby; Medicinal residues are standby;
(6) medicinal residues of getting (5) gained decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, and is standby;
(7) merge (4), (5), three kinds of thick pastes of (6) gained, being condensed into relative density is the clear paste of 1.1～1.3 (80～100 ℃), adds the fine powder of (2) gained, and mixing is made granule, drying; Get the hybrid medicine granule, standby;
(8) get (7) gained hybrid medicine granule, spray into the volatile oil of (3) gained, get hybrid medicine, add an amount of adjuvant, mixing is made drop pill or dispersible tablet;
(9) with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (8) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly gets drop pill;
(10) get the hybrid medicine granule of (7) gained, add an amount of adjuvant, mix homogeneously, behind granulation, drying, the granulate, mix homogeneously sprays into (3) gained volatile oil, is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable auxiliary material in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation of expelling heat to alleviate pain, it is that main component is to be clearing dropping pill or dispersible tablet on the Rhizoma Coptidis of Rhizoma Coptidis, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-fry), Radix Saposhnikoviae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Flos Chrysanthemi, Herba Menthae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Platycodonis, Rhizoma Chuanxiong, Gypsum Fibrosum, Flos Inulae, Radix Glycyrrhizae.
Chinese medicine preparation of the present invention is mainly used on the wind heat attacks, and has a dizzy spell epidemic hemorrhagic conjunctivitis, tooth pain, aphtha of the mouth and tongue, laryngopharynx swelling and pain, otalgia tinnitus, constipation, oliguria with reddish urine due to the exuberant lung-stomach heat.
A kind of preparation method of Chinese medicine preparation of expelling heat to alleviate pain is:
(1) medicine constituent and weight consumption thereof are as follows:
Rhizoma Coptidis 5g, Herba Menthae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Cortex Phellodendri, each 20g of Gypsum Fibrosum, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-fry), Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, each 40g of Radix Platycodonis, Flos Chrysanthemi 80g, Radix Et Rhizoma Rhei 160g, Flos Inulae 10g;
(2) get Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Gypsum Fibrosum, Rhizoma Coptidis powder and be broken into fine powder, sieve, mixing, standby;
(3) Herba Menthae, Fructus Forsythiae, extracting volatile oil from schizonepeta spike, the aqueous solution after the distillation device are in addition collected, and standby, medicinal residues are standby;
(4) medicinal residues of getting (3) gained decoct with water 2 times, each 1 hour, and collecting decoction filters, and filtrate is condensed into thick paste, and is standby;
(5) all the other ten flavor Flos Inulaes etc. are with the extraordinarily hot reflux 2 hours of 75% ethanol 8, and extracting solution recovery ethanol is condensed into thick paste, and is standby; Medicinal residues are standby;
(6) medicinal residues of getting (5) gained decoct with water 2 times, and each 1 hour, collecting decoction filters, and filters and is condensed into thick paste, and was standby;
(7) merge (4), (5), three kinds of thick pastes of (6) gained, being condensed into relative density is the clear paste of 1.25 (90 ℃), adds the fine powder of (2) gained, and mixing is made granule, and 80 ℃ of dryings get the hybrid medicine granule, and are standby;
(8) clearing dropping pill on the Chinese medicine preparation Rhizoma Coptidis of expelling heat to alleviate pain, its preparation method is the hybrid medicine granule 300g that gets (7) gained, sprays into the volatile oil of (3) gained, the Polyethylene Glycol PEG6000 300g behind the adding heating and melting, stearic acid 60g, Poloxamer188 30g is transferred to rapidly after stirring in the liquid containing bottle, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly gets drop pill.
(9) Yiqing dispersing tablets on the Chinese medicine preparation Rhizoma Coptidis of expelling heat to alleviate pain, its preparation method is the hybrid medicine granule 300g that gets (7) institute gained, add cross-linking polyethylene pyrrolidone 26g, low-substituted hydroxypropyl cellulose 36g, microcrystalline cellulose 108g, micropowder silica gel 2g cross 100 mesh sieves, mix homogeneously, cross 80 mesh sieve secondaries, spray into (3) gained volatile oil again, airtight moistening 12 hours, tabletting.
Advantage of the present invention is:
Drug effect rapidly, taking convenience, bioavilability height, be conducive to improve curative effect.
Claims (3)
1, a kind of Chinese medicine preparation of expelling heat to alleviate pain is characterized in that it is that main component is clearing dropping pill or a dispersible tablet on the Rhizoma Coptidis of Rhizoma Coptidis, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-fry), Radix Saposhnikoviae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Flos Chrysanthemi, Herba Menthae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Platycodonis, Rhizoma Chuanxiong, Gypsum Fibrosum, Flos Inulae, Radix Glycyrrhizae.
2, a kind of preparation method of Chinese medicine preparation of expelling heat to alleviate pain, it is the preparation method of clearing dropping pill or dispersible tablet on the Rhizoma Coptidis, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows: Rhizoma Coptidis 0.5～3%, Herba Menthae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Cortex Phellodendri, Gypsum Fibrosum each 2～6%, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-fry), Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Radix Platycodonis each 3～10%, Flos Chrysanthemi 8～15%, Radix Et Rhizoma Rhei 15～30%, Flos Inulae 1～5%;
(2) get Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Gypsum Fibrosum, Rhizoma Coptidis powder and be broken into fine powder, sieve, mixing, standby;
(3) Herba Menthae, Fructus Forsythiae, extracting volatile oil from schizonepeta spike are standby; Medicinal residues are standby;
(4) medicinal residues of getting (3) gained decoct with water 1～3 time, each 1～3 hour, and collecting decoction filters, and filtrate is condensed into thick paste, and is standby;
(5) all the other ten flavor Flos Inulaes etc. were with 60～80% alcohol heating reflux 1～3 hour, and extracting solution recovery ethanol is condensed into thick paste, and is standby; Medicinal residues are standby;
(6) medicinal residues of getting (5) gained decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, and is standby;
(7) merge (4), (5), three kinds of thick pastes of (6) gained, being condensed into relative density is the clear paste of 1.1～1.3 (80～100 ℃), adds the fine powder of (2) gained, and mixing is made granule, drying; Get the hybrid medicine granule, standby;
(8) get (7) gained hybrid medicine granule, spray into the volatile oil of (3) gained, get hybrid medicine; Add an amount of adjuvant, mixing is made drop pill or dispersible tablet;
(9) with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (8) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly gets drop pill;
(10) get (7) gained hybrid medicine granule, add adjuvant, mix homogeneously behind granulation, drying, the granulate, sprays into (3) gained volatile oil, is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable auxiliary material in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci.
3, the preparation method of the Chinese medicine preparation of a kind of expelling heat to alleviate pain according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Rhizoma Coptidis 0.7%, Herba Menthae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Cortex Phellodendri, Gypsum Fibrosum each 3.05%, Fructus Gardeniae, Fructus Forsythiae, Fructus Viticis (stir-frys), Herba Schizonepetae, the Radix Angelicae Dahuricae, Radix Scutellariae, Radix Platycodonis respectively 6.1%, Flos Chrysanthemi 12.4%, Radix Et Rhizoma Rhei 24.4%, Flos Inulae 1.5%.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297907B (en) * | 2008-06-05 | 2010-09-15 | 冯占英 | Preparation of Chinese medicine for curing sthenia fire type dentalgia |
| CN103006912A (en) * | 2012-12-27 | 2013-04-03 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Method for preparing medicine capsule for clearing away heat and loosing bowels and dispelling rheumatism to relieve pain |
| CN103196853A (en) * | 2013-04-15 | 2013-07-10 | 贵州百灵企业集团制药股份有限公司 | Method for detecting arsenic salt of Huanglian Shangqing tablets |
| CN104435619A (en) * | 2014-11-12 | 2015-03-25 | 王芳存 | Stomach-clearing and heat-discharging preparation for treating dizziness caused by flourishing heart and stomach fire and preparation method thereof |
| CN104825664A (en) * | 2014-02-11 | 2015-08-12 | 姜莉莉 | Traditional Chinese medicine formula for clearing heat, releasing the exterior, dissipating wind and relieving pain and preparation method thereof |
| CN105535275A (en) * | 2015-12-30 | 2016-05-04 | 韩志强 | Huanglian Shangqing tablet and preparation method thereof |
| CN105770200A (en) * | 2016-03-02 | 2016-07-20 | 南京正亮医药科技有限公司 | Preparing method and application of coptidis-rhizoma shangqing tablets |
| CN110559369A (en) * | 2019-08-06 | 2019-12-13 | 回音必集团安徽制药有限公司 | coptis chinensis tablet for clearing away heat of upper part of body and preparation method thereof |
-
2005
- 2005-06-24 CN CN 200510031756 patent/CN1709364A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297907B (en) * | 2008-06-05 | 2010-09-15 | 冯占英 | Preparation of Chinese medicine for curing sthenia fire type dentalgia |
| CN103006912A (en) * | 2012-12-27 | 2013-04-03 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Method for preparing medicine capsule for clearing away heat and loosing bowels and dispelling rheumatism to relieve pain |
| CN103196853A (en) * | 2013-04-15 | 2013-07-10 | 贵州百灵企业集团制药股份有限公司 | Method for detecting arsenic salt of Huanglian Shangqing tablets |
| CN104825664A (en) * | 2014-02-11 | 2015-08-12 | 姜莉莉 | Traditional Chinese medicine formula for clearing heat, releasing the exterior, dissipating wind and relieving pain and preparation method thereof |
| CN104435619A (en) * | 2014-11-12 | 2015-03-25 | 王芳存 | Stomach-clearing and heat-discharging preparation for treating dizziness caused by flourishing heart and stomach fire and preparation method thereof |
| CN105535275A (en) * | 2015-12-30 | 2016-05-04 | 韩志强 | Huanglian Shangqing tablet and preparation method thereof |
| CN105770200A (en) * | 2016-03-02 | 2016-07-20 | 南京正亮医药科技有限公司 | Preparing method and application of coptidis-rhizoma shangqing tablets |
| CN110559369A (en) * | 2019-08-06 | 2019-12-13 | 回音必集团安徽制药有限公司 | coptis chinensis tablet for clearing away heat of upper part of body and preparation method thereof |
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