CN1225268C - anhuang dripping pill and preparation thereof - Google Patents
anhuang dripping pill and preparation thereof Download PDFInfo
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- CN1225268C CN1225268C CN 03119774 CN03119774A CN1225268C CN 1225268 C CN1225268 C CN 1225268C CN 03119774 CN03119774 CN 03119774 CN 03119774 A CN03119774 A CN 03119774A CN 1225268 C CN1225268 C CN 1225268C
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Abstract
The present invention discloses a sanhuang dripping pill which is an improved dosage form of a sanhuang preparation. The present invention uses the extract of rhubarb, scutellaria root extractum and berberine hydrochloride as effective components, and uses polyethylene glycol as substrate. The effective components are pulverized, mixed and added in the melting substrate, and are uniformly stirred. Dimethyl silicon oil is dropped under a homothermal condition of 80 to 85 DEG C, and the effective components are condensed into dripping pills. The silicon oil is removed, and the effective components are made after dried. Because a solid dispersion method is used, a gap is small after the dripping pill substrate and a pharmaceutical granulate are combined. The contact area of the pharmaceutical granulate with the air is reduced, so the effective components are safe from influence of the air, and the stability is not reduced. The dripping pill has the advantages of fast dissolving speed, small pharmaceutical granulate and high bioavailability of active components. The dripping pill of the present invention is also easily dissolved in water to form solution.
Description
Technical field
The present invention relates to a kind of Chinese herbal and crude drugs preparations, particularly a kind of preparation reform of SANHUANG Chinese patent medicine is a kind of three new skullcap dripping pills.The invention still further relates to the preparation method of above-mentioned drop pill.
Background technology
SANHUANG is meant the abbreviation of Chinese herb rhubarb, Radix Scutellariae and Rhizoma Coptidis, the prescriptions of Chinese medicine that this SANHUANG is share is of long duration, function with heat clearing and damp drying, eliminating fire and detoxication, it can be used for diseases such as Sheng, hyperpyrexia agitation, aphtha of the mouth and tongue, conjunctival congestion headache, the red constipation of urinating, damp and hot yellow pestilence, dysentery, toxic swelling pain, hemorrhoid hematochezia in the three warmers.Began modern age to replace Rhizoma Coptidis, had identical effect with berberine hydrochloride.Because the determined curative effect of three yellow preparation, toxic and side effects is little, thereby very fast in the field of traditional Chinese development.There are dosage forms such as SANHUANG ball, Sanhuang San, SANHUANG tablet, Sanhuang capsules to occur up till now, use commonplace.
Advantages such as the modern medicine dosage form is upgraded very fast, has occurred as novel forms such as drops, and drop pill is made with solid dispersion method as a kind of novel form, has molten diffusing time weak point, and molten diffusing back granule is little, is beneficial to absorption, and onset is very fast.This dosage form has been applied to many medicines.But position up till now, people are not applied to this dosage form in the three yellow preparation.
Summary of the invention
The object of the present invention is to provide a kind of three skullcap dripping pills, the dosage form of three yellow preparation is reformed, improve the bioavailability of three yellow preparation, reduce manufacturing cost.
Three skullcap dripping pills of the present invention are to be effective ingredient with Radix Et Rhizoma Rhei extract, Radix Scutellariae extractum and berberine hydrochloride, with the Polyethylene Glycol is substrate, stir in the substrate with effective ingredient pulverizing mixing adding fusing, keep 80-85 degree centigrade constant temperature, the system of dripping is gone in the dimethicone, be condensed into drop pill, go the silicone oil drying to make.
Wherein every system 1000 balls need Radix Et Rhizoma Rhei 50 grams, need Radix Scutellariae extractum 3.5 grams, need berberine hydrochloride 0.833 gram, need Macrogol 4000 27 grams and PEG400 4 grams.
This above-mentioned Radix Scutellariae extractum makes through following method: Radix Scutellariae decocted with water three times, and 1.5 hours for the first time, 1 hour for the second time, 40 minutes for the third time; Collecting decoction filters, and filtrate adds hydrochloric acid and transfers pH value to 1～2; Quiescent setting 1 hour is washed with water to the washings pH value and is till 5～7; Oven dry, it is standby to be ground into fine powder.
This above-mentioned Radix Et Rhizoma Rhei needs to handle through following method, extracts useful component: Radix Et Rhizoma Rhei powder is broken into powder, and the alcohol heating reflux with 30% extracts three times, wherein adds for the first time the ethanol of 4 times of amounts, extracts 3 hours; Respectively add the ethanol of 3 times of amounts for the second time and for the third time, each extracted 1 hour; Distillate filters, and merging filtrate reclaims ethanol, is heated to 80-90 degree centigrade of drying under reduced pressure, and it is standby to be ground into fine powder.
The method that is used to prepare above-mentioned three skullcap dripping pills of the present invention may further comprise the steps:
A: extract the Radix Et Rhizoma Rhei useful component: take by weighing in proportion Radix Et Rhizoma Rhei, be ground into powder, the alcohol heating reflux with 30% extracts three times, wherein adds for the first time the ethanol of 4 times of amounts, extracts 3 hours; Respectively add the ethanol of 3 times of amounts for the second time and for the third time, each extracted 1 hour; Distillate filters, and merging filtrate reclaims ethanol, is heated to 80-90 degree centigrade of drying under reduced pressure, and it is standby to be ground into fine powder;
B: extract Radix Scutellariae extractum: Radix Scutellariae is decocted with water three times, 1.5 hours for the first time, 1 hour for the second time, 40 minutes for the third time; Collecting decoction filters, and filtrate adds hydrochloric acid and transfers pH value to 1～2; It is till 5～7 that quiescent setting 1 hour, precipitate are washed with water to the washings pH value; Oven dry, it is standby to be ground into fine powder;
C: fusing Polyethylene Glycol: take by weighing Macrogol 4000 and PEG400 in proportion, be heated to 85 degrees centigrade, fusing and abundant mix homogeneously;
D: Radix Et Rhizoma Rhei extract fine powder that step a and step b are obtained and Radix Scutellariae extractum fine powder and berberine hydrochloride are pulverized mix homogeneously, again in the Polyethylene Glycol that above-mentioned mixed powder adding steps d has been melted, and stir, remain under 85 degrees centigrade the condition, the system of dripping goes in the dimethicone to be condensed into drop pill.
After the above-mentioned drop pill system of dripping is finished, also comprise the process of removing silicone oil and dry coationg.
Three skullcap dripping pills of the invention described above are owing to used solid dispersion method, and drop pill substrate is little with drug particles fusion post gap, reduced the contact area of drug particles and air, make effective ingredient avoid air influence and reduce stability.The molten diffusing speed of this drop pill is fast, and drug particles is little, active component bioavailability height.Owing to uses Polyethylene Glycol to be substrate, can make drop pill of the present invention soluble in water and form solution, can modulate facing with before adding water, be more convenient for children's how the patient of dysphagia take, instructions of taking obviously is better than other solid dosage forms.
The specific embodiment
To prepare drop pill 1000 balls of the present invention is that example describes:
Extract Radix Et Rhizoma Rhei extract: take by weighing Radix Et Rhizoma Rhei 50 grams, be ground into fine powder, put into Backflow bottle, add the alcoholic solution of 200 grams 30%, be heated to boiling, condensing reflux 3 hours is collected distillate, and inclining liquid; Then add the ethanol of 150 grams 30% again, refluxed 1 hour, collect distillate; Then add the repetitive operation that ethanol 150 grams reflux, collect distillate; Filter distillate respectively, filter the back merging filtrate, reclaim ethanol, and under 85 degrees celsius, carry out drying under reduced pressure.Should be ground into fine powder by the drying thing again, standby as the Radix Et Rhizoma Rhei extract that the present invention uses.
The preparation Radix Scutellariae extractum: get an amount of Radix Scutellariae powder and be broken into fine powder, be placed in the container, add suitable quantity of water and decocted 1.5 hours, filter, residue decocts with water 1 hour again, filters, and residue decocts with water 40 minutes, filters; Merging filtrate also filters, adjusts with hydrochloric acid between pH value to 1～2 of filtrate, and quiescent setting 1 hour, precipitate washs between PH to 5～7 to washings with clear water; Oven dry precipitation, taking by weighing precipitate 3.5 grams, to be ground into fine powder standby.
Melt Polyethylene Glycol, take by weighing 27 gram Macrogol 4000s respectively and 4 gram PEG400s mix, put into container internal heating to 85 degree centigrade, make it to melt fully and stir insulation.
With above-mentioned Radix Et Rhizoma Rhei extract fine powder and Radix Scutellariae extractum fine powder 3.5, add berberine hydrochloride fine powder 0.833 gram again, fully mix homogeneously; The effective ingredient of this mix homogeneously is joined in the Polyethylene Glycol of 85 degrees centigrade of insulations, stir, keep constant temperature.
Remain on 85 degrees centigrade of homothermic materials and drip in the dimethicone of making room temperature and cool off above-mentioned, make it to form drop pill.
Remove the outer dimethicone of above-mentioned drop pill, dry coationg just makes three skullcap dripping pills, 1000 balls of the present invention.
Through overtesting, the molten diffusing speed of the drop pill of the invention described above is greater than tablet and capsule, and bioavailability also is greatly improved.And production method of the present invention can not produce pollution, does not need complex apparatus, and cost is lower.
Claims (6)
1. skullcap dripping pills, it is characterized in that: it is to be effective ingredient with Radix Et Rhizoma Rhei extract, Radix Scutellariae extractum and berberine hydrochloride, mixture with Macrogol 4000 and PEG400 is a substrate, stir in the substrate with effective ingredient pulverizing mixing adding fusing, keep 80-85 degree centigrade constant temperature, the system of dripping is gone in the dimethicone, is condensed into drop pill, goes the silicone oil drying to make.
2. three skullcap dripping pills according to claim 1 is characterized in that: every system 1000 balls need Radix Et Rhizoma Rhei 50 grams, need Radix Scutellariae extractum 3.5 grams, need berberine hydrochloride 0.833 gram, need Macrogol 4000 27 grams and PEG400 4 grams.
3. three skullcap dripping pills according to claim 2 is characterized in that: this Radix Scutellariae extractum makes through following method: Radix Scutellariae is decocted with water three times, and 1.5 hours for the first time, 1 hour for the second time, 40 minutes for the third time; Collecting decoction filters, and filtrate adds hydrochloric acid and transfers pH value to 1～2; Quiescent setting 1 hour is washed with water to the washings pH value and is till 5～7; Oven dry, it is standby to be ground into fine powder.
4. three skullcap dripping pills according to claim 2, it is characterized in that: this Radix Et Rhizoma Rhei needs to handle through following method, extracts useful component: Radix Et Rhizoma Rhei powder is broken into powder, and the alcohol heating reflux with 30% extracts three times, wherein add for the first time the ethanol of 4 times of amounts, extracted 3 hours; Respectively add the ethanol of 3 times of amounts for the second time and for the third time, each extracted 1 hour; Get distillate and filter, merging filtrate reclaims ethanol, is heated to 80-90 degree centigrade of drying under reduced pressure, and it is standby to be ground into fine powder.
5. a method for preparing described three skullcap dripping pills of claim 1 is characterized in that comprising the steps:
A: extract the Radix Et Rhizoma Rhei useful component: take by weighing in proportion Radix Et Rhizoma Rhei, be ground into powder, the alcohol heating reflux with 30% extracts three times, wherein adds for the first time the ethanol of 4 times of amounts, extracts 3 hours; Respectively add the ethanol of 3 times of amounts for the second time and for the third time, each extracted 1 hour; Distillate filters, and merging filtrate reclaims ethanol, is heated to 80-90 degree centigrade of drying under reduced pressure, and it is standby to be ground into fine powder;
B: extract Radix Scutellariae extractum: Radix Scutellariae is decocted with water three times, 1.5 hours for the first time, 1 hour for the second time, 40 minutes for the third time; Collecting decoction filters, and filtrate adds hydrochloric acid and transfers pH value to 1～2; Quiescent setting 1 hour is washed with water to the washings pH value and is till 5～7; Oven dry, it is standby to be ground into fine powder;
C: fusing Polyethylene Glycol: take by weighing Macrogol 4000 and PEG400 in proportion, be heated to 85 degrees centigrade, fusing and abundant mix homogeneously;
D: Radix Et Rhizoma Rhei extract fine powder that step a and step b are obtained and Radix Scutellariae extractum fine powder and berberine hydrochloride are pulverized mix homogeneously, again in the Polyethylene Glycol that above-mentioned mixed powder adding step c has been melted, and stir, remain under 85 degrees centigrade the condition, the system of dripping goes in the dimethicone to be condensed into drop pill.
6. the preparation method of three skullcap dripping pills according to claim 5 is characterized in that: after the system of dripping is finished, also comprise the process of removing silicone oil and dry coationg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03119774 CN1225268C (en) | 2003-03-12 | 2003-03-12 | anhuang dripping pill and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03119774 CN1225268C (en) | 2003-03-12 | 2003-03-12 | anhuang dripping pill and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1435251A CN1435251A (en) | 2003-08-13 |
| CN1225268C true CN1225268C (en) | 2005-11-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03119774 Expired - Fee Related CN1225268C (en) | 2003-03-12 | 2003-03-12 | anhuang dripping pill and preparation thereof |
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| Country | Link |
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| CN (1) | CN1225268C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370993C (en) * | 2006-01-11 | 2008-02-27 | 四川省中药研究所 | Medicinal composition with heat-clearing, fire-draining and detoxification function |
| CN108185023A (en) * | 2017-12-21 | 2018-06-22 | 陇南市朝华核桃产业开发有限公司 | A kind of Walnut oil dropping pills for promoting infant development and preparation method thereof |
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2003
- 2003-03-12 CN CN 03119774 patent/CN1225268C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1435251A (en) | 2003-08-13 |
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