CN101278958A - Feining dropping pill and method of preparing the same - Google Patents
Feining dropping pill and method of preparing the same Download PDFInfo
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- CN101278958A CN101278958A CNA2007100907593A CN200710090759A CN101278958A CN 101278958 A CN101278958 A CN 101278958A CN A2007100907593 A CNA2007100907593 A CN A2007100907593A CN 200710090759 A CN200710090759 A CN 200710090759A CN 101278958 A CN101278958 A CN 101278958A
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- herba senecionis
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Abstract
The invention discloses a medicine with the functions of clearing away heat and toxic substance, diminishing inflammation and alleviating pain, in particular to an oral dropping pill preparation which is made of Senecio Ccannabifolius as Chinese medicine material. The medicine can be used for treating influenza, laryngopharyngitis and pneumonia. The invention aims at providing an oral dropping pill with high bioavailability, rapid drug releasing, rapid marked effect and low price. The invention relates to Ferining dropping pill which uses the Senecio Ccannabifolius of Chinese medicine as raw material. The Senecio Ccannabifolius and a theriacal carrier as matrix are prepared to make the Ferining dropping pill.
Description
Technical field
The present invention designs a kind of antipyretic and antidote functions that has, and is used for the treatment of the medicine of diseases such as influenza, pharyngolaryngitis, pneumonia, is a kind of oral drop pills that raw material of Chinese medicine is prepared from the Chinese medicine Herba Senecionis cannabifolii particularly.The object of the present invention is to provide a kind of bioavailability height, and have quick release, quick produce effects, cheap oral formulations drop pill.
Background technology
According to 04 in Chinese medicine promulgated by the ministries or commissions of the Central Government, standard is numbered WS
3The peaceful granule of lung of-B-0747-91 preparation exist dose big, carry problem such as inconvenience.The corresponding peaceful conventional tablet of lung then exist onset slow, take problem such as inconvenience.Therefore the present invention adopts Herba Senecionis cannabifolii through extracting, refiningly obtaining the drop pill that its effective site and medicinal substrate are made jointly, has fully avoided the shortcoming of granule, tablets and other formulations, and can control the quality of this product better.
Beneficial effect
Chronic bronchitis is the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof, and the state of an illness is slowly made progress, Chang Bingfa obstructive emphysema, even pulmonary hypertension, pulmonary heart disease.It is a kind of commonly encountered diseases of serious harm people ' s health, sees with the old people especially more, and the person can be up to about 15% more than 50 years old.
The traditional Chinese medical science thinks that chronic bronchitis belongs to traditional Chinese medical science cough, cough with asthma category.And Herba Senecionis cannabifolii bitter in the mouth cold in nature is little sweet and hot, goes into lung, liver, large intestine channel, has the lung qi dispersing cough-relieving, reduces phlegm, relievings asthma, the effect of heat-clearing and toxic substances removing.Pharmacological research and clinical practice also show with the Herba Senecionis cannabifolii to be effects such as the preparation of raw material has antiinflammatory, antiviral, eliminates the phlegm, relievings asthma, antitussive, treatment chronic bronchitis and acute episode of chronic bronchitis and influenza, determined curative effect, and can improve cough, expectoration rapidly, symptom such as pant.
Herba Senecionis cannabifolii drop pill involved in the present invention is compared with the Herba Senecionis cannabifolii granule has following beneficial effect:
1,, shortened it in people intravital onset time at the effectiveness that keeps medicine and improved it in the intravital bioavailability of people.Reduced the taking dose of medicine simultaneously, made medicine carry, store, take convenient.
2, Herba Senecionis cannabifolii drop pill involved in the present invention gets matrix phase to activity of drug ingredients component extract and fusion and mixes, and splashes in the not miscible condensed fluid and makes.The stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
3, production technology, the equipment of preparation drop pill are simple, easy to operate, the automaticity height, and labor intensity is low, the production efficiency height.Workshop does not have dust simultaneously, helps labor protection and environmental protection yet.
4, do not contain sugar in the drop pill involved in the present invention, than sugar coated tablet, contain dosage forms such as sugared granule, oral liquid and enlarged the crowd of taking, can optionally take for certain patient who prohibits sugar.
The specific embodiment
To further instruction of the present invention, embodiment does not only mean that for explanatory it limits the scope of the invention by any way below in conjunction with embodiment.
Embodiment 1
The Chinese medicine Herba Senecionis cannabifolii is an amount of, decocts with water 3 times.Amount of water is 8 times of amounts for the first time, decocts 2 hours; Second and third time amount of water is 6 times of amounts, decocts to extract in 1 hour.Merge extractive liquid, filters, and filtrate is concentrated into thick paste.The thick paste drying under reduced pressure also is ground into impalpable powder.Get extract powder and add 3 times of fused PEG6000 of quality for 1 part, fully mixing.Other gets No. 100 dimethicone as condensing agent, and the condensing agent upper temp is 20 ℃, and bottom temp is 5 ℃.Drip and make ball, get final product.
Embodiment 2
The Chinese medicine Herba Senecionis cannabifolii is an amount of, adds 55% ethanol extraction 2 times.8 times of volumes soaked 30 minutes earlier for the first time, extracted 2 hours; 6 times of volumes extracted 1 hour for the second time.Merge extractive liquid, is concentrated into thick paste.The thick paste drying under reduced pressure also is ground into impalpable powder.In extract: PEG 6000 is that 1: 1.8 ratio adds fused PEG6000, and fully mixing be incubated 65～75 ℃, selects the water dropper of suitable bore for use, fast with dripping of 40～50 of per minutes, splashes in 10～15 ℃ the paraffin oil.Drip and make ball, get final product.
Embodiment 3
The Chinese medicine Herba Senecionis cannabifolii is an amount of, decocts with water 3 times.Amount of water is 8 times of amounts for the first time, decocts 2 hours; Second and third time amount of water is 6 times of amounts, decocts to extract in 1 hour.Merge extractive liquid, filters.It is 70% that filtrate adds ethanol to determining alcohol, leaves standstill, centrifugal.Supernatant reclaims ethanol to there not being the alcohol flavor, and spray drying gets Herba Senecionis cannabifolii extract.Other gets weight ratio is 99: 1 PEG6000 and PEG4000, heating and melting.The Herba Senecionis cannabifolii extract that adds the 30%PEG gross weight, abundant mixing splashes in 10～15 ℃ the methyl-silicone oil.Drip and make ball, get final product.
Embodiment 4
The Chinese medicine Herba Senecionis cannabifolii is an amount of, decocts with water 3 times.Amount of water is 8 times of amounts for the first time, decocts 2 hours; Second and third time amount of water is 6 times of amounts, decocts to extract in 1 hour.Merge extractive liquid, filters.It is 1.20～1.40 that filtrate is concentrated into density.Concentrated solution is collected 70% ethanol elution position and is reclaimed ethanol to there not being the alcohol flavor through the AB-8 macroporous resin treatment, and spray drying gets Herba Senecionis cannabifolii extract.Other gets weight ratio is 99: 1 PEG6000 and PEG4000, heating and melting.The Herba Senecionis cannabifolii extract that adds the 30%PEG gross weight, abundant mixing splashes in 10～15 ℃ the methyl-silicone oil.Drip and make ball, get final product.
Claims (14)
1. a medicine Feining dropping pill that is used for the treatment of viral influenza, pharyngolaryngitis, pneumonia etc. is a raw material with the Chinese medicine Herba Senecionis cannabifolii, is prepared from the pharmaceutically suitable carrier as substrate.
2. according to claim 1 described Feining dropping pill, the source of Chinese medicine Herba Senecionis cannabifolii is single leaf Herba Senecionis cannabifolii S.cannabifolius Less.Var.inlegrifolius (the K ǒ iz) Kitam of Compositae Senecio plant or the aerial parts of wide leaf Herba Senecionis cannabifolii Senecio cannabifolius Less or the herb of band root, also can be the combination of these two different proportion.
3. according to claim 1～2 any described Feining dropping pill, Chinese medicine Herba Senecionis cannabifolii raw material can be the extract of Herba Senecionis cannabifolii.Promptly get an amount of solvent of Herba Senecionis cannabifolii and extract 1～5 time, extracting solution obtains thick paste or exsiccant fine powder through suitable processing.
4. according to claim 3 described Feining dispersible tablets, Herba Senecionis cannabifolii extract can by water or ethanol or other organic solvent obtains by decoction, percolation, immersion or alternate manner.
5. according to claim 3 described Feining dispersible tablets, Herba Senecionis cannabifolii extracting solution or extractum can utilize other extracting mode to obtain, and obtain as adopting methods such as supercritical extraction, microwave heating.
6. according to claim 3 described Feining dropping pills, extracting thick paste can be that extracting solution directly concentrates by normal pressure or decompression or other method obtains, and obtains after also can passing through the microporous filter membrane of precipitate with ethanol, centrifugal, the different molecular amount of damming and various types of chromatographic column individual processing or two or more combined treatment earlier.
7. according to any described Feining dropping pill of claim 3～6 two kind, extracting solution or thick paste can obtain after treatment through after the macroporous resin enrichment of various models.
8. according to claim 3～7 described Feining dropping pills, extracting the exsiccant drying mode of thick paste can be the combination of a kind of or two or more modes in normal temperature drying, cold drying, lyophilization, drying under reduced pressure, the spray drying.
9. according to claim 1 described Feining dropping pill, its substrate is one or more the mixture in pharmaceutically suitable carrier such as Polyethylene Glycol (2000～20000), polyoxyethylene stearate 40 esters, beta-schardinger dextrin-, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac.
10. according to claim 1～9 any described Feining dropping pill, be unit with the weight or volume, the ratio of Chinese medicine extract and substrate is 1: 1～1: 9.
11. according to claim 1～10 any described Feining dropping pill, according to accurate weighing Chinese medicine extract of formula proportion and substrate, be placed on heating while stirring in the heating container, until the fused solution or emulsion or the suspension that obtain containing drug extract and substrate.
12. according to claim 1～10 any described Feining dropping pill, according to accurate weighing Chinese medicine extract of formula proportion and substrate, it is placed in the heating container heating while stirring respectively, obtain corresponding fused solution or emulsion or suspension respectively after, again with the two mixing.
13. according to claim 1～12 any described Feining dropping pill, can adopt self-control or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on 50～90 ℃, the temperature cooling of condensing agent also remains on (40～-5 ℃).To contain mixture abundant mixing under the condition close of raw material of Chinese medicine and substrate, place in the water dropper jar of drop pill machine, splash in the condensing agent, shrink molding promptly by water dropper with the water dropper temperature.
14. according to claim 13 described Feining dropping pills, the condensing agent that is adopted is that methyl-silicone oil or liquid paraffin or vegetable oil and other meet other material that pharmaceutical formulation requires.Also can be any two kinds or combination of the different proportion of two or more condensing agents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100907593A CN101278958A (en) | 2007-04-06 | 2007-04-06 | Feining dropping pill and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100907593A CN101278958A (en) | 2007-04-06 | 2007-04-06 | Feining dropping pill and method of preparing the same |
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| CN101278958A true CN101278958A (en) | 2008-10-08 |
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| CNA2007100907593A Pending CN101278958A (en) | 2007-04-06 | 2007-04-06 | Feining dropping pill and method of preparing the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940859A (en) * | 2012-08-16 | 2013-02-27 | 江西普正制药有限公司 | Preparation method of traditional Chinese medicine particles for treating cold and influenza |
| CN103417593A (en) * | 2013-07-12 | 2013-12-04 | 辽宁澎健药业有限公司 | Preparation method of lung-soothing concentration pill |
| CN103463157A (en) * | 2012-06-08 | 2013-12-25 | 吉林吉春制药股份有限公司 | Medicament for treating intrapulmonary infection and chronic bronchitis and preparation method thereof |
| CN103655778A (en) * | 2013-12-16 | 2014-03-26 | 无锡济民可信山禾药业股份有限公司 | Novel preparation for treating acute drug withdrawal syndrome and preparation method thereof |
| CN107576149A (en) * | 2017-07-24 | 2018-01-12 | 张家界湘汇生物有限责任公司 | A kind of drying means of plant extract product |
| CN108635391A (en) * | 2018-06-20 | 2018-10-12 | 吉林益民堂制药有限公司 | A kind of hempleaf groundsel herb phenolic acid components and the preparation method and application thereof |
-
2007
- 2007-04-06 CN CNA2007100907593A patent/CN101278958A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463157A (en) * | 2012-06-08 | 2013-12-25 | 吉林吉春制药股份有限公司 | Medicament for treating intrapulmonary infection and chronic bronchitis and preparation method thereof |
| CN102940859A (en) * | 2012-08-16 | 2013-02-27 | 江西普正制药有限公司 | Preparation method of traditional Chinese medicine particles for treating cold and influenza |
| CN103417593A (en) * | 2013-07-12 | 2013-12-04 | 辽宁澎健药业有限公司 | Preparation method of lung-soothing concentration pill |
| CN103417593B (en) * | 2013-07-12 | 2016-03-23 | 辽宁澎健药业有限公司 | The preparation of the peaceful concentrated pill of lung |
| CN103655778A (en) * | 2013-12-16 | 2014-03-26 | 无锡济民可信山禾药业股份有限公司 | Novel preparation for treating acute drug withdrawal syndrome and preparation method thereof |
| CN107576149A (en) * | 2017-07-24 | 2018-01-12 | 张家界湘汇生物有限责任公司 | A kind of drying means of plant extract product |
| CN108635391A (en) * | 2018-06-20 | 2018-10-12 | 吉林益民堂制药有限公司 | A kind of hempleaf groundsel herb phenolic acid components and the preparation method and application thereof |
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Addressee: Feng Zewang Document name: Written notice of preliminary examination of application for patent for invention |
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Open date: 20081008 |