CN102940859A - Preparation method of traditional Chinese medicine particles for treating cold and influenza - Google Patents
Preparation method of traditional Chinese medicine particles for treating cold and influenza Download PDFInfo
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- CN102940859A CN102940859A CN2012102918324A CN201210291832A CN102940859A CN 102940859 A CN102940859 A CN 102940859A CN 2012102918324 A CN2012102918324 A CN 2012102918324A CN 201210291832 A CN201210291832 A CN 201210291832A CN 102940859 A CN102940859 A CN 102940859A
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Abstract
The invention discloses a preparation method of traditional Chinese medicine particles for treating cold and influenza and belongs to the technical field of medicines. The preparation method comprises that isatis root, solidago decurrens, emilia sonchifolia, liquorice root and fresh ginger are subjected to superfine grinding, microwave heating extraction, alcohol precipitation, microwave extraction, standing, microfiltration membrane filtration, condensation and granulation. The preparation method has a short production period, short heating time, a high yield and less impurities, saves production time, improves an extraction ratio, reduces degradation and a loss of thermosensitive ingredients in a drug, reduces impurity content, simplifies extraction processes, reduces a production cost and improves product quality.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of preparation method for the treatment of the Chinese medicinal granule of flu and influenza.
Background technology
Flu is a kind of commonly encountered diseases and frequently-occurring disease, and coldrex is the standing medicine of family.Western medicine is not obvious to the therapeutic effect of flu, large works to improve symptom more, and treatment by Chinese herbs flu effect is apparent in view.The Chinese medicinal granule that is used for the treatment of flu and influenza is more, evident in efficacy in the clinical practice for the treatment of flu.Publication number is the preparation method that the Chinese patent application of CN1887339A discloses a kind of cold treating Yankeling, and the product of making by this preparation method is sugar type granules, thereby rapid-action with respect to tablet; With respect to syrup, more be applicable to the diabetes patient, and easy to carry, stability is better.But this preparation method is traditional Chinese medicine granules preparation method, adopts the effective ingredient in the medicine that traditional decocting mode of boiling directly extracts Herba Solidaginis, Herba Duchesneae Indicae, Radix Glycyrrhizae, Radix Isatidis, and Radix Glycyrrhizae powder is broken into fine powder, adds adjuvant again and is prepared from.The method is because to decoct temperature higher, and decocting time is longer, wastes time and energy, and energy consumption is high, and cause easily drug fever sensitive ingredient severe attrition and and then affect drug effect; And the Radix Glycyrrhizae fiber is more, and conventional the pulverizing is difficult to be ground into fully fine powder, affects the effective ingredient stripping; Simultaneously the quality of extract lacked effectively control, require extremely incompatible with the Chinese medicine preparation technical modernization.
Summary of the invention
The objective of the invention is for top described defective, the preparation method of the Chinese medicinal granule of a kind of simple to operate, extraction time is short and the medicament effective component extraction ratio is high treatment flu and influenza is provided.
The objective of the invention is to be achieved by the following technical programs.
A kind of preparation method for the treatment of the Chinese medicinal granule of flu and influenza is made by Radix Isatidis, Herba Solidaginis, Herba Duchesneae Indicae, Radix Glycyrrhizae and Rhizoma Zingiberis Recens, it is characterized in that, adopts the following steps preparation: 1. Radix Glycyrrhizae powder is broken into fine powder; 2. with Radix Isatidis take water as the solvent microwave extraction, extracting solution is concentrated by behind the precipitate with ethanol, the concentrated clear paste of Radix Isatidis that to get of Recycled ethanol; 3. with Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens three flavor medicines, take water as the solvent microwave extraction, aqueous extract leaves standstill, and gets supernatant concentration and gets the water extract clear paste; 4. with using filtering with microporous membrane after water extract clear paste and the clear paste of Radix Isatidis merging, be concentrated into thick paste; 5. thick paste adds Radix Glycyrrhizae fine powder, auxiliary materials and mixing, granulation, granulate, packing and get final product.
The Chinese medicinal granule of the influenza of described treatment flu is made by the crude drug of following weight portion: Radix Isatidis 10-40 part, Herba Solidaginis 10-40 part, Herba Duchesneae Indicae 10-60 part, Radix Glycyrrhizae 10-20 part, Rhizoma Zingiberis Recens 1-5 part.
Step 1. described Radix Glycyrrhizae powder adopts micronizing technique, is ground into and is no more than 200-300 purpose fine powder.
Step 2. described Radix Isatidis adopts extracting through microwave heating technique, the extracting through microwave heating of 200-800W 1-3 time, each 5-40 minute; The gained extracting solution filters after merging, and it is 1.05-1.15 that filtrate is concentrated into 50 ℃ of relative densities of gained clear paste; Add ethanol and make alcohol amount be 50%-80%, filter, behind the filtrate recycling ethanol concentrated when obtaining 50 ℃ relative density be the clear paste of Radix Isatidis of 1.05-1.15.
Step is described Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens three flavor medicines 3., adopt extracting through microwave heating technique, the extracting through microwave heating of 200-800W 1-3 time, each 5-40 minute; Gained water extraction liquid left standstill 12-24 hour, get supernatant concentration when obtaining 50 ℃ relative density be the water extract clear paste of 1.05-1.15.
Step is described filtering with microporous membrane 4., and the microporous filter membrane of employing is ceramic membrane and organic membrane, and the aperture is 0.1-10 μ m, and operating pressure is 0.05-0.5MPa; Relative density is 1.30-1.40 during 80 ℃ of concentrated gained thick pastes.
5. step behind described thick paste and Radix Glycyrrhizae fine powder, adjuvant dextrin, the steviosin mixing, adopts one-step palletizing, granulate, packing to make granule.
The invention has the beneficial effects as follows: the present invention adopts micronizing, microwave extraction, filtering with microporous membrane, one-step palletizing technique, have the characteristics such as with short production cycle, that heat time heating time is short, productive rate is high and impurity is few, saved the production time, improved extraction ratio, reduced degraded and the loss of heat-sensitive ingredients in the medicine, reduced impurity content, simplified extraction process, reduced production cost, improved the quality of product.
The specific embodiment
Embodiment 1.
Take by weighing Radix Isatidis 625g, Herba Solidaginis 750g, Herba Duchesneae Indicae 1000g, Radix Glycyrrhizae 375g, Rhizoma Zingiberis Recens 63g.Wherein Radix Glycyrrhizae is through being the Radix Glycyrrhizae fine powder of 200 mesh sieves after the micronizing.Radix Isatidis adds the water of 8 times of amounts, the extracting through microwave heating of employing 400w 2 times, each 15 minutes, the gained extracting solution filters after merging, filtrate is concentrated into relative density 1.10 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, filters, be concentrated into relative density 1.10 (50 ℃) behind the filtrate recycling ethanol, get clear paste of Radix Isatidis.Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens add the water of 10 times of amounts, the extracting through microwave heating of employing 400w 2 times, and each 15 minutes, the gained extracting solution left standstill 12 hours after merging, and got supernatant concentration to relative density 1.10 (50 ℃), got the water extract clear paste.It is interior pressure-pipe type ceramic micro filter film cross flow filter under 0.12MPa of 0.2um that clear paste of Radix Isatidis and water extract clear paste merge by the aperture, collects permeate, and permeate is concentrated, and to obtain relative density be 1.30(80 ℃) thick paste.After adding Radix Glycyrrhizae fine powder, 1350g dextrin, 10g steviosin mixing in the thick paste, adopt one-step palletizing, granulate, packing, namely get the about 1990g of granule.
Embodiment 2.
Take by weighing Radix Isatidis 625g, Herba Solidaginis 750g, Herba Duchesneae Indicae 1000g, Radix Glycyrrhizae 375g, Rhizoma Zingiberis Recens 63g.Wherein Radix Glycyrrhizae is through being the Radix Glycyrrhizae fine powder of 300 mesh sieves after the micronizing.Radix Isatidis adds the water of 8 times of amounts, the extracting through microwave heating of employing 600w 2 times, each 10 minutes, the gained extracting solution filters after merging, filtrate is concentrated into relative density 1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, filters, be concentrated into relative density 1.15 (50 ℃) behind the filtrate recycling ethanol, get clear paste of Radix Isatidis.Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens add the water of 10 times of amounts, the extracting through microwave heating of employing 600w 2 times, and each 10 minutes, the gained extracting solution left standstill 18 hours after merging, and got supernatant concentration to relative density 1.15 (50 ℃), got the water extract clear paste.It is interior pressure-pipe type ceramic micro filter film cross flow filter under 0.18MPa of 0.4um that clear paste of Radix Isatidis and water extract clear paste merge by the aperture, collects permeate, and permeate is concentrated, and to obtain relative density be 1.40(80 ℃) thick paste.After adding Radix Glycyrrhizae fine powder, 1300g dextrin, 10g steviosin mixing in the thick paste, adopt one-step palletizing, granulate, packing, namely get the about 1970g of granule.
Embodiment 3.
Take by weighing Radix Isatidis 2.7kg, Herba Solidaginis 3kg, Herba Duchesneae Indicae 4kg, Radix Glycyrrhizae 1.5kg, Rhizoma Zingiberis Recens 0.25kg.Wherein Radix Glycyrrhizae is through being the Radix Glycyrrhizae fine powder of 200 mesh sieves after the micronizing.Radix Isatidis adds the water of 8 times of amounts, the extracting through microwave heating of employing 600w 2 times, each 20 minutes, the gained extracting solution filters after merging, filtrate is concentrated into relative density 1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 75%, filters, be concentrated into relative density 1.10 (50 ℃) behind the filtrate recycling ethanol, get clear paste of Radix Isatidis.Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens add the water of 10 times of amounts, the extracting through microwave heating of employing 600w 2 times, and each 20 minutes, the gained extracting solution left standstill 24 hours after merging, and got supernatant concentration to relative density 1.10 (50 ℃), got the water extract clear paste.It is interior pressure-pipe type ceramic micro filter film cross flow filter under 0.14MPa of 0.8um that water extract clear paste and clear paste of Radix Isatidis merge by the aperture, collects permeate, and permeate is concentrated, and to obtain relative density be 1.35(80 ℃) thick paste.After adding Radix Glycyrrhizae fine powder, 5.5kg dextrin, 40g steviosin mixing in the thick paste, adopt one-step palletizing, granulate, packing, namely get the about 8kg of granule.
Embodiment 4.
Take by weighing Radix Isatidis 270kg, Herba Solidaginis 300kg, Herba Duchesneae Indicae 400kg, Radix Glycyrrhizae 150g, Rhizoma Zingiberis Recens 25kg.Wherein Radix Glycyrrhizae is through being the Radix Glycyrrhizae superfine powder of 200 mesh sieves after the micronizing.Radix Isatidis adds the water of 8 times of amounts, the extracting through microwave heating of employing 800w 2 times, each 30 minutes, the gained extracting solution filters after merging, filtrate is concentrated into relative density 1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 70%, filters, be concentrated into relative density 1.05 (50 ℃) behind the filtrate recycling ethanol, get clear paste of Radix Isatidis.Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens add the water of 10 times of amounts, the extracting through microwave heating of employing 800w 2 times, and each 30 minutes, the gained extracting solution left standstill 12 hours after merging, and got supernatant concentration to relative density 1.05 (50 ℃), got the water extract clear paste.It is interior pressure-pipe type ceramic micro filter film cross flow filter under 0.10MPa of 1.0um that clear paste of Radix Isatidis and water extract clear paste merge by the aperture, collects permeate, and permeate is concentrated, and to obtain relative density be 1.40(80 ℃) thick paste.After adding Radix Glycyrrhizae superfine powder, 550kg dextrin, 4kg steviosin mixing in the thick paste, adopt one-step palletizing, granulate, packing, namely get the about 800kg of granule.
Claims (7)
1. a preparation method for the treatment of the Chinese medicinal granule of flu and influenza is made by Radix Isatidis, Herba Solidaginis, Herba Duchesneae Indicae, Radix Glycyrrhizae and Rhizoma Zingiberis Recens, it is characterized in that, adopts the following steps preparation: 1. Radix Glycyrrhizae powder is broken into fine powder; 2. with Radix Isatidis take water as the solvent microwave extraction, extracting solution is concentrated by behind the precipitate with ethanol, the concentrated clear paste of Radix Isatidis that to get of Recycled ethanol; 3. with Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens three flavor medicines, take water as the solvent microwave extraction, aqueous extract leaves standstill, and gets supernatant concentration and gets the water extract clear paste; 4. with using filtering with microporous membrane after water extract clear paste and the clear paste of Radix Isatidis merging, be concentrated into thick paste; 5. thick paste adds Radix Glycyrrhizae fine powder, auxiliary materials and mixing, granulation, granulate, packing and get final product.
2. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1, it is characterized in that: the Chinese medicinal granule of the influenza of described treatment flu, made by the crude drug of following weight portion: Radix Isatidis 10-40 part, Herba Solidaginis 10-40 part, Herba Duchesneae Indicae 10-60 part, Radix Glycyrrhizae 10-20 part, Rhizoma Zingiberis Recens 1-5 part.
3. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1, it is characterized in that: step is described Radix Glycyrrhizae powder employing micronizing technique 1., is ground into and is no more than 200-300 purpose fine powder.
4. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1, it is characterized in that: step 2. described Radix Isatidis adopts extracting through microwave heating technique, the extracting through microwave heating of 200-800W 1-3 time, 5-40 minute at every turn; The gained extracting solution filters after merging, and it is 1.05-1.15 that filtrate is concentrated into 50 ℃ of relative densities of gained clear paste; Add ethanol and make alcohol amount be 50%-80%, filter, behind the filtrate recycling ethanol concentrated when obtaining 50 ℃ relative density be the clear paste of Radix Isatidis of 1.05-1.15.
5. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1, it is characterized in that: step is described Herba Solidaginis, Herba Duchesneae Indicae, Rhizoma Zingiberis Recens three flavor medicines 3., adopt extracting through microwave heating technique, the extracting through microwave heating of 200-800W 1-3 time, each 5-40 minute; Gained water extraction liquid left standstill 12-24 hour, get supernatant concentration when obtaining 50 ℃ relative density be the water extract clear paste of 1.05-1.15.
6. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1, it is characterized in that: step is described filtering with microporous membrane 4., the microporous filter membrane that adopts is ceramic membrane and organic membrane, and the aperture is 0.1-10 μ m, and operating pressure is 0.05-0.5MPa; Relative density is 1.30-1.40 during 80 ℃ of concentrated gained thick pastes.
7. a kind of preparation method for the treatment of flu and the Chinese medicinal granule of influenza according to claim 1 is characterized in that: 5. behind described thick paste and Radix Glycyrrhizae fine powder, adjuvant dextrin, the steviosin mixing, employing one-step palletizing, granulate, packing make granule to step.
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| CN2012102918324A CN102940859A (en) | 2012-08-16 | 2012-08-16 | Preparation method of traditional Chinese medicine particles for treating cold and influenza |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104273623A (en) * | 2013-07-12 | 2015-01-14 | 冯桂芬 | Auxiliary cold prevention beverage |
| CN109173422A (en) * | 2018-10-09 | 2019-01-11 | 飞潮（无锡）过滤技术有限公司 | The complete filtering technique of batch of process API medical fluid before a kind of medicine production transfer is brilliant |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104273623A (en) * | 2013-07-12 | 2015-01-14 | 冯桂芬 | Auxiliary cold prevention beverage |
| CN109173422A (en) * | 2018-10-09 | 2019-01-11 | 飞潮（无锡）过滤技术有限公司 | The complete filtering technique of batch of process API medical fluid before a kind of medicine production transfer is brilliant |
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Application publication date: 20130227 |