CN102119952A - Ultrasonic extraction preparation method of Chinese traditional medicine preparation for treating lumbago due to kidney deficiency - Google Patents
Ultrasonic extraction preparation method of Chinese traditional medicine preparation for treating lumbago due to kidney deficiency Download PDFInfo
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- CN102119952A CN102119952A CN 201110051326 CN201110051326A CN102119952A CN 102119952 A CN102119952 A CN 102119952A CN 201110051326 CN201110051326 CN 201110051326 CN 201110051326 A CN201110051326 A CN 201110051326A CN 102119952 A CN102119952 A CN 102119952A
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Abstract
The invention belongs to the technical field of Chinese traditional medicine, and in particular relates to an ultrasonic extraction preparation method of a Chinese traditional medicine preparation for treating lumbago due to the kidney deficiency. The ultrasonic extraction preparation method comprises the following steps of: taking coarse powder of 250g of eucommia ulmoides and 1250g of folium cortex eucommiae, adding water and performing ultrasonic extraction for 30-50 minutes at the extraction temperature of 30-50 DEG C, filtering the extracted liquid, concentrating the filtrate until the relative density of the concentrate is about 1.20-1.30, cooling to room temperature, precipitating by adding 2.8 times of ethanol, filtering, concentrating the filtrate into extract with the relative density of about 1.10-1.15, and adding a proper amount of dextrin and sweetening agent or auxiliary materials to the extract to prepare medicaments. The ultrasonic extraction preparation method provided by the invention adopts the preparation process by an ultrasonic extraction technique, and the active components in the medicines are fully released under the ultrasonic action, thus improving the utilization ratio of the active components, shortening the short extraction time, increasing the yield, improving the product yield and purity, improving the curative effect of the medicament, and maximizing the medicinal value of the medicament.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of preparation method for the treatment of the ultrasonic extraction Chinese medicine preparation of lumbago due to renal deficiency.
Background technology
The medicine of modern relevant treatment lumbago due to renal deficiency is a lot, but adopt the technology of traditional water extract-alcohol precipitation to produce more, extraction time is long, energy consumption is big in the heating decoction process, active ingredient can not fully extract, and active ingredients a large amount of in the medical material do not discharge fully, causes the waste of medical material, reduce curative effect, increased cost.Sharp rise at price of medicinal material now, under the medical material situation in short supply, require to adopt new process means that the active ingredient in the medical material is extracted as much as possible, will cut down the consumption of energy simultaneously.Just there is above-mentioned deficiency in the method for making of the accurate word Z22022790 of traditional Chinese medicines number " Cortex Eucommiae electuary ".Its prescription is: Cortex Eucommiae 250g, Folium Eucommiae 1250g.Method for making: above two flavors, the Cortex Eucommiae decocts with water three times, 3 hours for the first time, adds Folium Eucommiae for the second time and decocts 2 hours, 1 hour for the third time, collecting decoction filters, and filtrate is concentrated into relative density and is about 1.24 (60 ℃), be chilled to room temperature, add 2.8 times of amount ethanol and make precipitation, filter, filtrate is concentrated into the clear paste that relative density is 1.13～1.15 (60 ℃).1 part of qinghuo reagent, with 5 parts of sucrose, mixing is made granule, drying, promptly.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive, blood pressure lowering.Be used for lumbago due to renal deficiency, weakness of the waist and knees, frequent fetal movement, threatened abortion, vascular hypertension.
Summary of the invention
The present invention seeks to adopt advanced ultrasonic wave extraction, provide rapid-action, good effect, stay-in-grade a kind of preparation method for the treatment of the ultrasonic extraction Chinese medicine preparation of lumbago due to renal deficiency.
Technical solution of the present invention is: the preparation method of the ultrasonic extraction Chinese medicine preparation of treatment lumbago due to renal deficiency, may further comprise the steps: (1) gets Cortex Eucommiae 250g, Folium Eucommiae 1250 coarse powder (40 order) by the accurate word Z22022790 prescription of traditional Chinese medicines, add water ultrasonic extraction 30～50min, extract 30～50 ℃ of temperature, extracting solution filters, filtrate is concentrated into relative density and is about 1.20-1.30 (60 ℃), be chilled to room temperature, add 2.8 times of amount ethanol and make precipitation, filter, filtrate is concentrated into the clear paste that relative density is about 1.10-1.15 (60 ℃);
(2) qinghuo reagent adds an amount of dextrin and sweeting agent or adjuvant, makes granule, drying, and electuary is made in pack; Or make tablet; Or make hard capsule; Promptly.Wherein every 1g contains the Cortex Eucommiae and Folium Eucommiae with chlorogenic acid (C
16H
18O
9) meter, must not be less than 0.50mg.
The present invention adopts the ultimate principle of ultrasound assisted extraction technique, the leaching that utilizes cavitation effect of ultrasonic waves to quicken effective ingredients in plant is extracted, hyperacoustic in addition second order effect, as mechanical vibration, emulsifying, spread, smash, chemical effect etc., also can quicken desire and extract diffusion release and abundant and the solvent of composition, be beneficial to extraction.
Advantage of the present invention is: 1, adopt ultrasound assisted extraction technique preparation technology, the active ingredient in the medical material fully discharges under action of ultrasonic waves, improved the utilization rate of active ingredient, improved the curative effect of this Chinese medicine preparation, reduced production cost, easily large-scale production.2, extraction time is short, yield is high, need not heating, simplify operation sequence greatly, shortened extraction time, improved product yield and purity, improved not only loaded down with trivial details time-consuming but also easy emulsive extracting method commonly used, reduced and extract energy consumption, save cost, active ingredient in the medical material is in the obvious raising of chlorogenic acid simultaneously, and the preparation of making has improved curative effect of medication, bring into play the medical value of this medicine to greatest extent, bring excellent curative to the patient.3, technology is simple, advanced, and is feasible.
Table 1 extracts assay (in preparation) for different ultrasonic time active ingredient chlorogenic acids,
Table 2 extracts different time active ingredient determination of chlorogenic acid (in preparation) for tradition.
Table 1
Table 2
The specific embodiment
Embodiment 1
The preparation method of the ultrasonic extraction Chinese medicine preparation of treatment lumbago due to renal deficiency: 1, get Cortex Eucommiae 250g, Folium Eucommiae 1250 coarse powder (40 order), add water ultrasonic extraction 40min, extracting solution filters, filtrate is concentrated into relative density and is about 1.20-1.30 (60 ℃), be chilled to room temperature, add 2.8 times of amount ethanol and make precipitation, filter, filtrate is concentrated into the clear paste that relative density is about 1.10-1.15 (60 ℃).2, qinghuo reagent, the dextrin and 1% sweeting agent of adding 25% are made granule, drying, electuary is made in pack, promptly.
Embodiment 2
The preparation method of the ultrasonic extraction Chinese medicine preparation of treatment lumbago due to renal deficiency: 1, get Cortex Eucommiae 250g, Folium Eucommiae 1250 coarse powder (40 order), add water ultrasonic extraction 40min, extracting solution filters, filtrate is concentrated into relative density and is about 1.20-1.30 (60 ℃), be chilled to room temperature, add 2.8 times of amount ethanol and make precipitation, filter, filtrate is concentrated into the clear paste that relative density is about 1.10-1.15 (60 ℃).2, qinghuo reagent, the starch of adding 25% is made granule, drying, tabletting is made tablet, promptly.
Embodiment 3
The preparation method of the ultrasonic extraction Chinese medicine preparation of treatment lumbago due to renal deficiency: 1, get Cortex Eucommiae 250g, Folium Eucommiae 1250 coarse powder (40 order), add water ultrasonic extraction 40min, extracting solution filters, filtrate is concentrated into relative density and is about 1.20-1.30 (60 ℃), be chilled to room temperature, add 2.8 times of amount ethanol and make precipitation, filter, filtrate is concentrated into the clear paste that relative density is about 1.10-1.15 (60 ℃); 2, qinghuo reagent, the starch of adding 25% is made granule, drying, the hard capsule of packing into, promptly.
Claims (1)
1. preparation method for the treatment of the ultrasonic extraction Chinese medicine preparation of lumbago due to renal deficiency may further comprise the steps:
(1) gets Cortex Eucommiae 250g, Folium Eucommiae 1250 coarse powder, add water ultrasonic extraction 30～50min, extract 30～50 ℃ of temperature, extracting solution filters, filtrate is concentrated into 60 ℃ of following relative densities and is about 1.20-1.30, is chilled to room temperature, adds 2.8 times of amount ethanol and makes precipitation, filter, filtrate is concentrated into the clear paste that is about 1.10-1.15 60 ℃ of following relative densities;
(2) qinghuo reagent adds dextrin and sweeting agent or adjuvant, makes granule, drying, and electuary is made in pack; Or make tablet; Or make hard capsule; Promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201110051326 CN102119952A (en) | 2011-03-04 | 2011-03-04 | Ultrasonic extraction preparation method of Chinese traditional medicine preparation for treating lumbago due to kidney deficiency |
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| CN 201110051326 CN102119952A (en) | 2011-03-04 | 2011-03-04 | Ultrasonic extraction preparation method of Chinese traditional medicine preparation for treating lumbago due to kidney deficiency |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039995A (en) * | 2012-12-20 | 2013-04-17 | 苏州天南星生物科技有限公司 | Health-care food |
| CN103623030A (en) * | 2013-11-26 | 2014-03-12 | 百花医药集团股份有限公司 | Eucommia ulmoides oral preparation and preparation method thereof |
| CN111714566A (en) * | 2020-07-22 | 2020-09-29 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine extract for tonifying liver and kidney and preventing miscarriage and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101486651A (en) * | 2009-02-10 | 2009-07-22 | 江苏省苏微微生物研究有限公司 | Method for extracting chlorogenic acid from Eucommia leaves and use thereof |
| CN101912434A (en) * | 2010-07-30 | 2010-12-15 | 郑家桂 | Medicament for treating hypertension and insomnia and preparation method thereof |
-
2011
- 2011-03-04 CN CN 201110051326 patent/CN102119952A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101486651A (en) * | 2009-02-10 | 2009-07-22 | 江苏省苏微微生物研究有限公司 | Method for extracting chlorogenic acid from Eucommia leaves and use thereof |
| CN101912434A (en) * | 2010-07-30 | 2010-12-15 | 郑家桂 | Medicament for treating hypertension and insomnia and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 《中药成方制剂第10册》 19951231 中华人民共和国卫生部药典委员会 杜仲冲剂 68 1 , 1 * |
| 《林产化学与工业》 19990930 孙波等 超声波提取杜仲叶的工艺研究 67-70 1 第19卷, 第3期 2 * |
| 《西北林学院学报》 20030331 董娟娥等 超声波提取杜仲叶中有效成分工艺研究 66-68 1 第18卷, 第3期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039995A (en) * | 2012-12-20 | 2013-04-17 | 苏州天南星生物科技有限公司 | Health-care food |
| CN103623030A (en) * | 2013-11-26 | 2014-03-12 | 百花医药集团股份有限公司 | Eucommia ulmoides oral preparation and preparation method thereof |
| CN111714566A (en) * | 2020-07-22 | 2020-09-29 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine extract for tonifying liver and kidney and preventing miscarriage and preparation method thereof |
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Application publication date: 20110713 |