CN102119966B - Preparation method of Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction - Google Patents
Preparation method of Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction Download PDFInfo
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- CN102119966B CN102119966B CN201110051436XA CN201110051436A CN102119966B CN 102119966 B CN102119966 B CN 102119966B CN 201110051436X A CN201110051436X A CN 201110051436XA CN 201110051436 A CN201110051436 A CN 201110051436A CN 102119966 B CN102119966 B CN 102119966B
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of a Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction. The preparation method comprises the following steps of: washing Chinese magnoliavine fruit by using water, performing wall-breaking and drying treatment through a microwave tunnel oven and crushing, wherein the microwave power is 20kW, and the speed of a conveyor belt is 2m/second; adding three times water and soaking for 1 hour; decocting for three times, wherein the first time is 3 hours, the second time is 2 hours, and the third time is 1 hour; filtering medicinal liquid, mixing filtrate, concentrating at the temperature of 50 DEG C until thick paste with relative density of between 1.20 and 1.35 is obtained, drying under vacuum, and smashing until the fineness reaches 100 meshes; and adding 10 to 20 percent of starch into the smashed medicinal powder, uniformly mixing, and encapsuling to prepare hard capsules or tablets to obtain the Chinese medicinal preparation. By an advanced microwave wall-broken technology of a traditional Chinese medicine, active ingredients in medicinal materials are fully released, so that the utilization ratios of the medicinal materials are greatly improved, and a medicinal effect is increased.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to the method for preparing that a kind of microwave assistant of treating hepatitis disease extracts Chinese medicine preparation.
Background technology
In the prior art, hepatitis is the general terms of liver inflammation.Can refer to a papova property disease, promptly usually said first, second, third, fourth, defend type hepatitis, five kinds of hepatitis viruss are propagated through different approaches, are one of common but severe infectious disease, and its common trait is infected liver and causes the liver inflammation.Also have owing to abuse of alcohol in addition, make medicament or taken in the hepatitis that the environment toxicity causes.The various hepatitis of China is presenting ascendant trend, has every year nearly 400,000 people to die from hepatic disease, and chronic viral hepatitis B and lost hepatitis C are just becoming the healthy killer of compatriots.In case become the hepatitis patient,, also increased white elephant for society and family not only for patient and family members thereof bring huge misery.The accurate word Z20026446 of traditional Chinese medicines number " Fructus Schisandrae Chinensis capsule " treatment hepatitis disease effect is obvious.Its prescription is: Fructus Schisandrae Chinensis extrat 150g, starch 50g.Process 1000.Method for making: get Fructus Schisandrae Chinensis extrat, add starch, be mixed, incapsulate, promptly get.The Fructus Schisandrae Chinensis extrat method for making: get Fructus Schisandrae Chinensis 1450g, crushing adds 3 times of water gagings and soaked 1 hour, decocts three times; 3 hours for the first time, 2 hours for the second time, 1 hour for the third time; Filter, merging filtrate also is concentrated into the thick paste that relative density is 1.20～1.35 (50 ℃), cold drying (30～40 ℃); Be ground into fine powder, process 100g, promptly get.Function cures mainly: liver and kidney tonifying.Be used for hepatitis and belong to deficiency of the liver and kindey disease.Its shortcoming is: adopt traditional production process to be prepared from, active ingredient absorbs slower, and not thorough, drug effect is slow, affects the treatment.
Summary of the invention
The object of the invention is to provide a kind of modern advanced process means that utilizes, and provides a kind of microwave assistant of treatment hepatitis disease of method for preparing better effects if to extract the method for preparing of Chinese medicine preparation.
Technical solution of the present invention is: 1, a kind of microwave assistant of treating hepatitis disease extracts the method for preparing of Chinese medicine preparation, may further comprise the steps:
(1) get the Fructus Schisandrae Chinensis water and clean after, carry out the breaking cellular wall oven dry through the microwave tunnel baking oven and handle, microwave power 20kw, line speed 2m/ second, crushing;
(2) add 3 times of water loggings bubble 1 hour, decocts 3 times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, medicinal liquid filtered, merging filtrate and under 50 ℃, to be concentrated into relative density be 1.20～1.35 thick paste, and vacuum drying, pulverizing, fineness is 100 orders;
(3) add 10～20% starch in the medicated powder after pulverizing, mixing incapsulates, and processes hard capsule or processes tablet, promptly gets.
The present invention is the character of medicinal material according to Fructus Schisandrae Chinensis; Adopt the single medicinal material extract to process preparation, its function can make serum transaminase descend rapidly, and wherein the enzyme rate of falling of chronic hepatitis is higher; And hepatoprotective is arranged, promote the effect of liver synthetic proteins, liver cell regeneration, and strengthen the function of detoxification of liver.
Advantage of the present invention is: 1, adopted advanced Chinese medicine microwave wall breaking technology, overcome the shortcoming that traditional extraction process can not thoroughly propose active ingredient, be the basis with microwave penetration property heating principle; Be that microwave is three-dimensional heating to material; In the microwave field, it can produce the each second frequency of vibration is tens times microwave, and makes the hydrone movement therewith in the moistening crude drug cell; Violent motion produces a large amount of heat energy; Make in the crude drug cell hydrone vaporization, breaking cellular wall and going out, thus reach the purpose of medicinal material drying; Meanwhile, the crude drug cell wall breaks, and when extracting, active ingredient fully discharges in the medical material, has improved the utilization rate of medical material greatly, thereby has increased drug effect.Use preparation of the present invention, the active ingredient of medicine improves greatly, has improved bioavailability, and the extract showed increased.2, do not have medical material directly to pulverize material in this preparation, improve so the amount of human drug absorption's active ingredient is all detailed in the unit interval, drug effect is faster, acts on stronger.
Table 1 is that tradition is extracted and the contrast of microwave breaking cellular wall assistance extraction active ingredient schisandrin assay.
Table 1
To combine embodiment that embodiment of the present invention is described in further detail below.
The specific embodiment
Embodiment 1
The microwave assistant of treatment hepatitis disease extracts the method for preparing of Chinese medicine preparation: 1, get Fructus Schisandrae Chinensis 1450g, water cleans, and carries out the breaking cellular wall oven dry through the microwave tunnel baking oven and handles microwave power 20kw; Line speed 2m/ second, crushing adds 3 times of water loggings bubbles 1 hour, decocts 3 times; 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, medicinal liquid filtered; Merging filtrate also is concentrated into the thick paste that relative density is 1.20～1.35 (50 ℃), and vacuum drying is pulverized, and fineness is 100 orders; 2, get 15% starch, process gelatinized corn starch, join in the medicated powder, mixing, tabletting, coating is processed tablet, promptly gets.
Embodiment 2
The microwave assistant of treatment hepatitis disease extracts the method for preparing of Chinese medicine preparation: 1, get Fructus Schisandrae Chinensis 1450g, water cleans, and carries out the breaking cellular wall oven dry through the microwave tunnel baking oven and handles crushing; Add 3 times of water logging bubbles 1 hour, decoct 3 times, 3 hours for the first time, 2 hours for the second time; 1 hour for the third time, medicinal liquid filtered, and merging filtrate also is concentrated into the thick paste that relative density is 1.20～1.35 (50 ℃); Vacuum drying is pulverized, and fineness is 100 orders; 2, get 15% starch, join in the medicated powder, mixing incapsulates, and processes hard capsule, promptly gets.
Claims (1)
1. a microwave assistant of treating hepatitis disease extracts the method for preparing of Chinese medicine preparation, may further comprise the steps:
(1) get the Fructus Schisandrae Chinensis water and clean after, carry out the breaking cellular wall oven dry through the microwave tunnel baking oven and handle, microwave power 20kw, line speed 2m/ second, crushing;
(2) add 3 times of water loggings bubble 1 hour, decocts 3 times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, medicinal liquid filtered, merging filtrate and under 50 ℃, to be concentrated into relative density be 1.20～1.35 thick paste, and vacuum drying, pulverizing, fineness is 100 orders;
(3) add 10～20% starch in the medicated powder after pulverizing, mixing incapsulates, and processes hard capsule or processes tablet, promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110051436XA CN102119966B (en) | 2011-03-04 | 2011-03-04 | Preparation method of Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110051436XA CN102119966B (en) | 2011-03-04 | 2011-03-04 | Preparation method of Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction |
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| CN102119966A CN102119966A (en) | 2011-07-13 |
| CN102119966B true CN102119966B (en) | 2012-11-14 |
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| CN201110051436XA Active CN102119966B (en) | 2011-03-04 | 2011-03-04 | Preparation method of Chinese medicinal preparation for treating hepatitis disease by microwave-assisted extraction |
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Families Citing this family (3)
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| CN103976293A (en) * | 2013-11-14 | 2014-08-13 | 上海紫石生物科技有限公司 | Production methods of okra fruit powder |
| CN112106887A (en) * | 2020-09-30 | 2020-12-22 | 李星海 | Preparation method of medicated diet feed for feeding poultry and livestock |
| CN115300558A (en) * | 2022-10-10 | 2022-11-08 | 茂名市人民医院 | Exocarpium citri grandis processing device and method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768891A (en) * | 2004-11-05 | 2006-05-10 | 济南倍力粉技术工程有限公司 | Extraction method and equipment of Chinese medicinal active component |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768891A (en) * | 2004-11-05 | 2006-05-10 | 济南倍力粉技术工程有限公司 | Extraction method and equipment of Chinese medicinal active component |
Non-Patent Citations (5)
| Title |
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| 关芯蕊，等.北五味子提取物在天然调味料中的开发利用.《中国食品添加剂》.2007,(第4期),110-113. * |
| 彭修娟,等.不同加工方法对南五味子质量的影响.《陕西中医学院学报》.2007,第30卷(第3期),40-41. * |
| 王威，刘传斌，修志龙.高山红景天苷提取新工艺.《中草药》.1999,(第11期),824-826. * |
| 王晓丰,赵洪波.振动微粉机在中药生产中的应用与发展.《机电信息》.2006,(第S1期),55-59. * |
| 黄惠华，梁汉华.利用微波辅助萃取技术提取五味子果实中五味子醇甲的研究.《天然产物研究与开发》.2006,第18卷(第1期),112~116. * |
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Address after: 134001 Tonghua city of Jilin Province Dongchang District medicine Road No. 3998 Patentee after: TONGHUA YUSHENG PHARMACEUTICAL CO., LTD. Address before: 134001 Tonghua city of Jilin Province Dongchang District medicine Road No. 3998 Patentee before: Tonghua Yusheng Pharmaceutical Co., Ltd. |