CN102579984A - Method for preparing Xinnaokang capsule - Google Patents
Method for preparing Xinnaokang capsule Download PDFInfo
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- CN102579984A CN102579984A CN2012100567802A CN201210056780A CN102579984A CN 102579984 A CN102579984 A CN 102579984A CN 2012100567802 A CN2012100567802 A CN 2012100567802A CN 201210056780 A CN201210056780 A CN 201210056780A CN 102579984 A CN102579984 A CN 102579984A
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Abstract
The invention discloses a method for preparing a Xinnaokang capsule. Medicinal herbs are sterilized by reducing the pressure of ethanol gas before medicine preparing according to the method disclosed by the invention, and thus the Chinese traditional medicine can be sterilized at low temperature (below 80 DEC C) without destroying effective ingredients of the Chinese traditional medicine. During granulation, the air temperature is 85 to 95 DEG C, the exhaust temperature is 45 to 55 DEG C, and the temperature of the materials is 50 to 60 DEG C, the material retention time is 2-3 hours,, the spraying frequency is 5 to 8 Hz, and the moisture content in particles is less than 2.0 percent. The granulation is a one-step granulation method with integration of mixing, granulating and drying, thus the working hours are saved, and the production efficiency is improved; and the heating time of the medicinal herbs is shortened, the loss of effective ingredients is reduced, and the product quality is indirectly increased. Since the medicine is processed into grains and the grains are filled into capsules according to the invention, the workshop can be prevented from being polluted by flying dust when the medical powder is filled in the capsules, the preparation method is conducive to the fluidity of the powder, and the filling amount of the capsules can be controlled easily.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, relate to a kind of method for preparing of XINNAOKANG JIAONANG.
Background technology
XINNAOKANG JIAONANG is a national essential drugs; Form by Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, Fructus Lycii, Radix Puerariae, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Pheretima, Radix Curcumae, Radix Polygalae (processed with honey), Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Cor Cervi powder, Radix Glycyrrhizae 16 flavor Chinese medicines; Cure mainly blood circulation promoting and blood stasis dispelling, understand things pain-stopping; Be used for the thoracic obstruction, dizzy due to the obstruction of collaterals by blood stasis, that disease is seen is uncomfortable in chest, pareordia twinge, dizzy, headache; Angina pectoris, cerebral arteriosclerosis are seen above-mentioned disease person.XINNAOKANG JIAONANG rose to the Chinese Pharmacopoeia standard in 2010.The method of granulating of pharmacopeia regulation is time-consuming, and production cost is higher; The heated time of pharmacy procedure Chinese medicine is long simultaneously, and effective ingredient is prone to loss.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of XINNAOKANG JIAONANG.
In order to realize above purpose, the technical scheme that the present invention adopts is:
A kind of method for preparing of XINNAOKANG JIAONANG may further comprise the steps:
(1) Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Curcumae, Radix Polygalae, Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Radix Glycyrrhizae nine flavor medical materials are sterilized with the alcohol gas decompression earlier, mix and pulverize, cross 100 mesh sieves, mix homogeneously;
(2) get Radix Salviae Miltiorrhizae, Fructus Lycii, Pheretima, Radix Paeoniae Rubra, Radix Puerariae, Radix Polygoni Multiflori Preparata Six-element medical material adding extraction pot; Extracting in water three times; The each extraction adds 6-8 times of water gaging; Decocted 1-3 hour, and merged three times decoction liquor, filtrate decompression is condensed into the extractum that relative density is 1.19～1.21 (77 ℃～83 ℃);
(3) with crossing 80 mesh sieves behind step (1) the medicated powder adding extractum mix homogeneously, granulate; With 40 eye mesh screen granulate, get the granule below 40 orders, subsequent use;
(4) the magnesium stearate mix homogeneously of step (3) gained granule, Cor Cervi powder and grain amount 0.7%, filled capsules, packing, warehouse-in after the assay was approved.
Temperature is 65-75 ℃ during step (1) decompression sterilization, more than the vacuum 0.085MPa.
During step (2) concentrating under reduced pressure, one imitates 70～85 ℃ of temperature, vacuum 0.02～0.05MPa; Two imitate 60～75 ℃ of temperature, vacuum 0.04～0.07MPa.
The temperature EAT was 85～95 ℃ when step (3) was granulated, and temperature of outgoing air is 45～55 ℃, and temperature of charge is 50～60 ℃, residence time of material 2～3 hours, and the hydrojet frequency is 5～8Hz, pellet moisture content is less than 2.0%.
Before pharmacy, the present invention has carried out alcohol gas decompression sterilization to medical material, can sterilize to the prepared slices of Chinese crude drugs at lower temperature (below 80 ℃), does not destroy the effective ingredient of the prepared slices of Chinese crude drugs.The present invention processes particles filled capsule with medicine, and the filled capsules dust from flying pollutes the workshop when having avoided medicine to process powder, also helps the flowability of powder body simultaneously, is easy to control the capsule loading amount.The method of granulating that the present invention uses has been saved man-hour for integrating the marumerization of mixing, granulation, drying, has improved production efficiency; Shorten the heated time of medicine, reduced loss of active ingredients, improved product quality indirectly.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further explanation.
Embodiment 1: the method for preparing of present embodiment XINNAOKANG JIAONANG may further comprise the steps:
(1) Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Curcumae, Radix Polygalae, Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Radix Glycyrrhizae nine flavor medical materials are sterilized with the alcohol gas decompression earlier: open the heater steam valve and make steam pressure≤0.4MPa; Adjustment heater steam valve and condensed water valve make the cabinet chamber slowly be heated to 65 ℃; After temperature was raised to set point of temperature, extracting vacuum was opened vacuum pump and is evacuated down to more than the vacuum 0.085MPa, closes vacuum pump.Suction 90% alcoholic solution (consumption is pressed every cubic metre of cabinet volume and calculated with ethanol 4L).Alcoholic solution is closed the effusion meter valve after all feeding sterilizer, closes heater steam and gets into valve, closes valves all except that ganging up valve.Keep alcohol gas sterilization 12 hours, temperature natural drops to below 50 ℃, and vacuum is unclamped take-up device less than 0.02MPa in the machine, opens the cabinet door and gets final product discharging, mixes then and pulverizes, and crosses 100 mesh sieves, mix homogeneously;
(2) get Radix Salviae Miltiorrhizae, Fructus Lycii, Pheretima, Radix Paeoniae Rubra, Radix Puerariae, Radix Polygoni Multiflori Preparata Six-element medical material adding extraction pot, first pass adds 8 times of water gagings, boils 3 hours; Add 7 times of water gagings for second time, boiled 2 hours; Add 6 times of water gagings the 3rd time, boiled 1 hour; Merge three times decoction liquor, filtrate decompression is concentrated, concentrate and adopt the energy-conservation concentrator of economic benefits and social benefits, wherein one to imitate temperature be that 70 ℃, vacuum are 0.02MPa; Two to imitate temperature be that 60 ℃, vacuum are 0.04MPa.When the extractum relative density is 1.19 (80 ± 3 ℃), goes out cream, and cross 100 mesh sieves;
(3) with crossing 80 mesh sieves behind step (1) the medicated powder adding extractum mix homogeneously, the temperature EAT is 85 ℃ when granulating drying, and temperature of outgoing air is 45 ℃; Temperature of charge is 50 ℃; Residence time of material 2 hours, hydrojet frequency are 5Hz, and pellet moisture content is less than 2.0%.With 40 eye mesh screen granulate, get the granule below 40 orders, subsequent use;
(4) the magnesium stearate mix homogeneously of step (3) gained granule and grain amount 0.7%, filled capsules, packing, warehouse-in after the assay was approved.
Embodiment 2: the method for preparing of present embodiment XINNAOKANG JIAONANG may further comprise the steps:
(1) Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Curcumae, Radix Polygalae, Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Radix Glycyrrhizae nine flavor medical materials are sterilized with the alcohol gas decompression earlier: open the heater steam valve and make steam pressure≤0.4MPa; Adjustment heater steam valve and condensed water valve make the cabinet chamber slowly be heated to 70 ℃; After temperature was raised to set point of temperature, extracting vacuum was opened vacuum pump and is evacuated down to more than the vacuum 0.085MPa, closes vacuum pump.Suction 90% alcoholic solution (consumption is pressed every cubic metre of cabinet volume and calculated with ethanol 4L).Alcoholic solution is closed the effusion meter valve after all feeding sterilizer, closes heater steam and gets into valve, closes valves all except that ganging up valve.Keep alcohol gas sterilization 12 hours, temperature natural drops to below 50 ℃, and vacuum is unclamped take-up device less than 0.02MPa in the machine, opens the cabinet door and gets final product discharging, mixes then and pulverizes, and crosses 100 mesh sieves, mix homogeneously;
(2) get Radix Salviae Miltiorrhizae, Fructus Lycii, Pheretima, Radix Paeoniae Rubra, Radix Puerariae, Radix Polygoni Multiflori Preparata Six-element medical material adding extraction pot, first pass adds 8 times of water gagings, boils 3 hours; Add 7 times of water gagings for second time, boiled 2 hours; Add 6 times of water gagings the 3rd time, boiled 1 hour; Merge three times decoction liquor, filtrate decompression is concentrated, concentrate and adopt the energy-conservation concentrator of economic benefits and social benefits, wherein one to imitate temperature be that 80 ℃, vacuum are 0.04MPa; Two to imitate temperature be that 70 ℃, vacuum are 0.06MPa.When the extractum relative density is 1.20 (80 ± 3 ℃), goes out cream, and cross 100 mesh sieves;
(3) with crossing 80 mesh sieves behind step (1) the medicated powder adding extractum mix homogeneously, the temperature EAT is 90 ℃ when granulating drying, and temperature of outgoing air is 50 ℃; Temperature of charge is 55 ℃; Residence time of material 2.5 hours, hydrojet frequency are 7Hz, and pellet moisture content is less than 2.0%.With 40 eye mesh screen granulate, get the granule below 40 orders, subsequent use;
(4) the magnesium stearate mix homogeneously of step (3) gained granule and grain amount 0.7%, filled capsules, packing, warehouse-in after the assay was approved.
Embodiment 3: the method for preparing of present embodiment XINNAOKANG JIAONANG may further comprise the steps:
(1) Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Curcumae, Radix Polygalae, Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Radix Glycyrrhizae nine flavor medical materials are sterilized with the alcohol gas decompression earlier: open the heater steam valve and make steam pressure≤0.4MPa; Adjustment heater steam valve and condensed water valve make the cabinet chamber slowly be heated to 75 ℃; After temperature was raised to set point of temperature, extracting vacuum was opened vacuum pump and is evacuated down to more than the vacuum 0.085MPa, closes vacuum pump.Suction 90% alcoholic solution (consumption is pressed every cubic metre of cabinet volume and calculated with ethanol 4L).Alcoholic solution is closed the effusion meter valve after all feeding sterilizer, closes heater steam and gets into valve, closes valves all except that ganging up valve.Keep alcohol gas sterilization 12 hours, temperature natural drops to below 50 ℃, and vacuum is unclamped take-up device less than 0.02MPa in the machine, opens the cabinet door and gets final product discharging, mixes then and pulverizes, and crosses 100 mesh sieves, mix homogeneously;
(2) get Radix Salviae Miltiorrhizae, Fructus Lycii, Pheretima, Radix Paeoniae Rubra, Radix Puerariae, Radix Polygoni Multiflori Preparata Six-element medical material adding extraction pot, first pass adds 8 times of water gagings, boils 3 hours; Add 7 times of water gagings for second time, boiled 2 hours; Add 6 times of water gagings the 3rd time, boiled 1 hour; Merge three times decoction liquor, filtrate decompression is concentrated, concentrate and adopt the energy-conservation concentrator of economic benefits and social benefits, wherein one to imitate temperature be that 85 ℃, vacuum are 0.05MPa; Two to imitate temperature be that 75 ℃, vacuum are 0.07MPa.When the extractum relative density is 1.21 (80 ± 3 ℃), goes out cream, and cross 100 mesh sieves;
(3) with crossing 80 mesh sieves behind step (1) the medicated powder adding extractum mix homogeneously, the temperature EAT is 95 ℃ when granulating drying, and temperature of outgoing air is 55 ℃; Temperature of charge is 60 ℃; Residence time of material 3 hours, hydrojet frequency are 8Hz, and pellet moisture content is less than 2.0%.With 40 eye mesh screen granulate, get the granule below 40 orders, subsequent use;
(4) the magnesium stearate mix homogeneously of step (3) gained granule and grain amount 0.7%, filled capsules, packing, warehouse-in after the assay was approved.
Claims (4)
1. the method for preparing of an XINNAOKANG JIAONANG is characterized in that may further comprise the steps:
(1) Rhizoma Chuanxiong, Flos Carthami, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Radix Curcumae, Radix Polygalae, Rhizoma Anemones Altaicae, Semen Ziziphi Spinosae (parched), Radix Glycyrrhizae nine flavor medical materials are sterilized with the alcohol gas decompression earlier, mix and pulverize, cross 100 mesh sieves, mix homogeneously;
(2) get Radix Salviae Miltiorrhizae, Fructus Lycii, Pheretima, Radix Paeoniae Rubra, Radix Puerariae, Radix Polygoni Multiflori Preparata Six-element medical material adding extraction pot; Extracting in water three times; The each extraction adds 6-8 times of water gaging; Decocted 1-3 hour, and merged three times decoction liquor, filtrate decompression is condensed into the extractum that relative density is 1.19～1.21 (77 ℃～83 ℃);
(3) with crossing 80 mesh sieves behind step (1) the medicated powder adding extractum mix homogeneously, granulate; With 40 eye mesh screen granulate, get the granule below 40 orders, subsequent use;
(4) the magnesium stearate mix homogeneously of step (3) gained granule, Cor Cervi powder and grain amount 0.7%, filled capsules, packing, warehouse-in after the assay was approved.
2. the method for preparing of XINNAOKANG JIAONANG according to claim 1 is characterized in that: temperature is 65-75 ℃ during step (1) decompression sterilization, more than the vacuum 0.085MPa.
3. the method for preparing of XINNAOKANG JIAONANG according to claim 1 is characterized in that: during step (2) concentrating under reduced pressure, one imitates 70～85 ℃ of temperature, vacuum 0.02～0.05MPa; Two imitate 60～75 ℃ of temperature, vacuum 0.04～0.07MPa.
4. the method for preparing of XINNAOKANG JIAONANG according to claim 1; It is characterized in that: the temperature EAT was 85～95 ℃ when step (3) was granulated; Temperature of outgoing air is 45～55 ℃, and temperature of charge is 50～60 ℃, residence time of material 2～3 hours; The hydrojet frequency is 5～8Hz, and pellet moisture content is less than 2.0%.
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| CN2012100567802A CN102579984A (en) | 2012-03-06 | 2012-03-06 | Method for preparing Xinnaokang capsule |
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| CN2012100567802A CN102579984A (en) | 2012-03-06 | 2012-03-06 | Method for preparing Xinnaokang capsule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106444688A (en) * | 2016-12-07 | 2017-02-22 | 宜春万申制药机械有限公司 | Integrated intelligent pharmaceutical system |
| CN115814039A (en) * | 2022-02-09 | 2023-03-21 | 吉林省正和药业集团股份有限公司 | Xinnaokang capsule and large-batch and efficient preparation method thereof |
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| CN101569736A (en) * | 2008-04-29 | 2009-11-04 | 北京亚东生物制药有限公司 | Quality control method of Xinnaokang capsule |
| CN102000304A (en) * | 2010-11-29 | 2011-04-06 | 杨凌无为制药集团有限公司 | Method for preparing Xinnaokang capsules |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106444688A (en) * | 2016-12-07 | 2017-02-22 | 宜春万申制药机械有限公司 | Integrated intelligent pharmaceutical system |
| CN115814039A (en) * | 2022-02-09 | 2023-03-21 | 吉林省正和药业集团股份有限公司 | Xinnaokang capsule and large-batch and efficient preparation method thereof |
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Application publication date: 20120718 |