CN101773636A - Antitumor nanometer Chinese medicine and production method thereof - Google Patents
Antitumor nanometer Chinese medicine and production method thereof Download PDFInfo
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Abstract
The invention relates to antitumor nanometer Chinese medicine and a production method thereof. The antitumor nanometer Chinese medicine comprises the following raw material composition of active ingredients in percentage by weight: dozens of kinds of Chinese medicine such as 20 to 30 of gamene, 30 to 40 of euphorbia fisheriana, 23 to 30 of achyranthes, 15 to 25 of arisaema cum bile, 40 to 50 of radix scutellariae and the like. The method comprises the production processes of ultrasonic pulverization extraction dispersion, microwave leaching, supersonic speed spray drying pulverization, nanometer grinding, mixing and capsule filling. The recipe has the antitumor treatment effect, has no toxic or side effect, and is suitable for being used for treating various tumor patients. Through the treatment measures of replenishing qi to invigorate the spleen, removing dampness to reduce phlegm, reasonably matching assistant and guide medicine and the like, the recipe is finely divided into five time preparations: a monitoring preparation, a noon preparation, an evening preparation, a midnight preparation and a late-night preparation, each preparation contains no more than 20 kinds of Chinese medicine, the preparations are respectively taken in four time intervals according to the flowing rule of the meridional flow injected into qi and blood of human bodies, and the antitumor nanometer Chinese medicine can also be used for local skin application and acupuncture point medication percutaneous absorption treatment on human bodies according to different periods.
Description
Technical field
The present invention relates to a kind of anti-tumor nano Chinese medicine preparation medicine, the invention still further relates to this medicament nano powder preparing and production method thereof.
Background technology
Big quantity research studies show that, most of malignancy disease and human virus increase substantial connection, eliminate that tumor suppresses virus from killing, cuts off the blood supply of tumor blood capillary, replenishing QI to invigorate the spleen, raising immunity are started with, and to can yet be regarded as be an efficient ways, nanometer Chinese medicine is one of effective ways of the thoroughly various tumor diseases of radical cure." Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments beginning gives birth to " proposed the generation and the class card of " amassing ", all by " cold is living; fainting is to become also. " " trembling with fear ", comprise exopathogenic factor, endogenous cause of ill and eliological factors being neither endogenous nor exogenous and eventually cause vigour and decay, the kidney-Yang loss, Kidney-Yin exhaustion, gasification reaches partially, the cold coagulation stasis, and the turbid cohesion of expectorant is given birth to. and cold life then gas is contracted, the gas then stasis of contracting is puckery, causing cold warm prosperity and decline and cause eventually in the human body three YIN and three YANG and hide mansion meridians vim and vigour dysfunction of the spleen in transportation and transformation, make vigour can not positive conventional conductor liquid etc. be circulated in whole body the exterior and the interior, condense because of cold. cancer is the cell of doubtful property of stagnating, be that normal cell has lost quick function alive, thereby can not newly pursue katabolism, and treat to fall causing to a certain degree to healthy energy, given the puckery cells survival condition of doubting, cause gradually coalescently, become eventually carcinoma.At present, angiogenesis has become the field, forward position of tumor research, suppresses tumor by angiogenesis inhibiting and is called the 4th kind of tumor therapy after operation, chemotherapy, radiotherapy by scientific circles.The more important thing is, in theory most tumors are all had effect, thereby have wide research prospect because the method is the purpose that reaches the treatment tumor by the nutrient supply that cuts off tumor.This prescription has to be set upright timid heresy, blocks, suppresses neonate tumour blood vessel, train first invigorating YANG, replenishing QI to invigorate the spleen, hard masses softening and resolving, temperature male wind-supplying kidney, heat-clearing and toxic substances removing, timid expectorant damp eliminating, treating the poisonous disease with poisonous drugs, activating blood circulation and dissipating blood stasis, eliminating phlegm and removing dampness, liver and kidney tonifying, the resolving depression of regulating the flow of vital energy, blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, removing food stagnancy and dispersing accumulation, capture relieve oedema or abdominal distension through diuresis or purgation, effect such as nourishing YIN and benefiting blood, replenishing YIN and removing heat, warming YANG to expel cold, heart tonifying lung benefiting.Function cures mainly: train first invigorating YANG, QI invigorating is set upright, block, suppress neonate tumour blood vessel, kill virus, enhancing human body immunity function.Can be used for the kinds of tumors patient, low leukocyte counts that a variety of causes causes and minimizing disease.
A large amount of investigation confirms that the generation of tumor, control and trace element " selenium " are closely related.Lacking " selenium " crowd tumor incidence in the body, is 2-6 times of high selenium crowd; " selenium " content is low more in the blood, and cancer mortality is high more; Obviously lack in the oncosis human bodies such as breast carcinoma, colon cancer, gastric cancer, pulmonary carcinoma, hepatocarcinoma on " selenium ".The tumor patient that lacks " selenium " has short possibility of metastasis, grade malignancy height and life cycle more." selenium " has five big effect enantiopathy evil spirits: one, improving immunologic function raising resistance " selenium " influences cellular immunization, humoral immunization and nonspecific immunity significantly.Can also promote lymphocyte to produce antibody, the haematogenic immunity globulin levels is increased or keep normal.Two, improve antioxidant ability of organism,, make lipid peroxide, hydrogen peroxide etc. obtain removing by selenoenzyme.Three, the blocking-up tumor vessel forms, and prevents tumor recurrence, transfer, cuts off the nutrition supply channel of tumor cell, withered gradually, extinction.Four, direct killing tumor cell, " selenium " increases the level of cyclic adenosine monophosphate in the cancerous cell (CAMP), plays and suppresses tumor cell DNA, RNA and protein synthesis, the effect of the Growth and Differentiation of control tumor cell, thereby cancer inhibitting and killing cell.Five, get rid of toxin health care health, " selenium " can strengthen " separating toxenzyme " activity in the body, and carcinogen was excluded in the past in the performance carcinogenic effect.This prescription is to adopt sun to make main dialectical opinion greater than cloudy theory to control method, pays attention to the human body integral idea, adopts nano-selenium rich Chinese medicine Synergistic treatment scheme.Emphasize that the vital organs of the human body, the four stages in the course of an epidemic febrile disease, body fluid marrow are in harmonious proportion with mending, the cold warm medicine of a cold nature of heat and develop simultaneously, flow to the position medication of timesharing branch by the midnight-noon and ebb-flow doctrine QI and blood with, inside and outside administration.This prescription is by distinguishing negative and positive, monarch reasonable compatibility etc., that the Chinese medicine of will filling a prescription is divided into is early, middle and late, night five prescriptions, each prescription is no more than 20 flavor Chinese medicines, takes five time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Nanometer Chinese medicine is made plaster be attached to the affected part, can and need not inject by the direct absorption of skin, this will make traditional Chinese medical science interior disease external therapy, Chinese medicine antiviral drugs theory and curative effect generation major transformation.
Further, the granule that these various rich selenium Chinese medicine nanometer particle size major parts of filling a prescription are 40～250 nanometers (approaching) with the virus size, can directly enter in the blood after taking, tumor locus, and viral adsorption, block the blood supply of tumor cell blood capillary, the man-to-man contact, viral adsorption firmly, tumor cell (adsorption of surface charge), make virus, the tumor cell LOM, cut off tumor cell blood capillary blood supply function, make it to enter the cellular replication breeding,, make virion become big because of the Nano medication particle has stronger adsorption, can be easily by phagocyte identification parcel, metabolism goes out external.In addition, the nanometer Chinese medicinal granule also has tunnel-effect, and penetrable hepatocyte strengthens the attack of nanometer selenium to virus, tumor cell, and absorption is also got rid of intracellular virus, and virus is thoroughly removed, and infected tissue is recovered fully.The anti-curing oncoma of this prescription and effective ingredient thereof realizes that by many target spots, multipath, too many levels its antineoplastic action mechanism mainly comprises regulates body's immunity, inhibition tumor vascular growth, inducing apoptosis of tumour cell, inducing tumor cell differentiation, reversing tumor cell multi-drug resistant, the conduction of regulate tumor cell signal, inhibition telomerase activation and cytotoxicity etc.The theoretical basis of this prescription selenium-enriched nano Chinese medicine and effective ingredient thereof will be opened up new approach for human virus, tumor treatment.
The present invention fills a prescription to adopt high-frequency ultrasonic to extract to pulverize and adds the microwave extracting mode and carry out medicine and propose extraction, process route is: extract pulverizing with high-frequency ultrasonic earlier, ultrasonic power: 800W-3000W, supersonic frequency: 28KHz-120KHz, to pulverize extraction time be 10-100 minute, carry out microwave extracting then, microwave power is set under the 40-80% (1000 watts of peak powers), make solvent with 38%--45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Containing the liquid medicinal residues adopts conventional Chinese medicine extraction percolation squeezing and pressing method to extract, extracting solution adopts supersonic speed (temperature 10-60 degree after concentrating, pressure 0.01-0.65Mpa, supersonic jet speed is 350 meters-980 meter per seconds) spray drying is crushed to the 1-5 micron grain size, connecing down the swing nanon ball-mill that adopts independent research ground 4-16 hour, obtaining particle size distribution is the nanometer Chinese medicine of 40-500 nanometer, the Nano Chinese medicine powder end is mixed by above-mentioned formula proportion in GMP10000 level toilet by version Chinese Pharmacopoeia second portion standard preparation standard in 2005 at last, make capsule, aforementioned various preparations such as tablet.After finishing, Production and Packaging unify sterilization to appointment cobalt 60 irradiation centers by production batch.
The effect of main Chinese medicine in this prescription: the antitumor of this prescription Chinese medicine, antiviral activity composition mainly are flavonoid, terpenoid, polysaccharide, alkaloids, protein-based, and multiple material such as phenols, sterol, lignanoid, mainly contain glycyrrhizic acid, polyporusum bellatus, resveratrol, curcumin, astragalus polysaccharides, cinnamic aldehyde, ephedrine, hypericin, chlorogenic acid, gamlogic acid or the like.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and a kind of anti-tumor nano Chinese medicine preparation and production method thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
A kind of anti-tumor nano Chinese medicine, wherein: this nanometer Chinese medicine raw materials of effective components and weight proportion---
Radix Rubiae 20-30, Euphorbia fischeriana S teud 30-40, Radix Achyranthis Bidentatae 23-30, Arisaema Cum Bile 15-25, Radix Scutellariae 40-50, Flos Inulae 20-30, Radix Glycyrrhizae Preparata 5-20, Radix Astragali 40-60, Rhizoma Smilacis Glabrae 30-40, Rhizoma Polygoni Cuspidati 40-50, Radix Aconiti Lateralis Preparata 50-60, Herba Artemisiae Scopariae 30-40, Radix Morindae Officinalis 30-40, Fructus Schisandrae Chinensis 10-20, Rhizoma Atractylodis Macrocephalae 10-20, Herba Scutellariae Barbatae 20-30, Herba Asari 6-15, Ramulus Cinnamomi 30-40, Radix Sophorae Tonkinensis 30-40, Fructus Trichosanthis 30-40, Rhizoma Anemarrhenae 20-30, Radix Notoginseng 20-30, Radix Salviae Miltiorrhizae 30-40, Radix Angelicae Sinensis 30-40, Flos Lonicerae 30-40, Herba Phyllanthi Urinariae 40-50, Cortex Eucommiae 20-30, rhizoma sparganic 30-40, Rhizoma Curcumae 30-40, Rhizoma Curcumae Longae 30-40, Fructus Toosendan 30-40, Radix Morindae Officinalis 30-40, Scorpio 20-30, Radix Codonopsis 30-40, Herba Ephedrae 10-20, Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Polygoni Multiflori 20-30, Semen Coicis 30-40, Placenta Hominis 20-30, Lignum Cudraniae tricuspidatae 20-30, Ganoderma 20-30, Bulbus Fritillariae Uninbracteatae 20-30, Spica Prunellae 20-30, Fructus Crataegi 20-30, Herba Epimedii 30-40, Herba Andrographis 20-30, Concha Ostreae 20-30, Radix Bupleuri 30-40, Radix Asparagi 20-30, Semen Plantaginis 20-30, Cortex Mori 20-30, Fructus Mori 20-30, Herba Solani Nigri 20-30, Squama Manis 20-30, Rhizoma Chuanxiong 20-30, Rhizoma Pinelliae 40-50, Myrrha 20-30, Herba Cistanches 20-30, Hedyotidis Diffusae 20-30, field dobber 20-30, Radix Rehmanniae 20-30, Radix Arnebiae (Radix Lithospermi) 20-30, Flos Carthami 20-30, Fructus Ligustri Lucidi 20-30, Rhizoma Polygonati 20-30, Herba Violae 20-30, Semen Lablab Album 20-30, Polyporus 20-30, Herba Taraxaci 20-30, Hirudo 20-30, Rhizoma Curculiginis 20-30, Rhizoma Dioscoreae 20-30, Cortex Eucommiae 20-30, Eupolyphaga Seu Steleophaga 15-25, Resina garciniae 20-30, Gekko Swinhonis 10-25, Radix Et Caulis Acanthopanacis Senticosi 20-30, Bombyx Batryticatus 20-30, Rhizoma Dioscoreae Bulbiferae 20-30, Endothelium Corneum Gigeriae Galli 20-30, Caulis Spatholobi 25-35, Pheretima 20-30, Pericarpium Arecae 10-25, Radix Tripterygii Wilfordii 25-35.
Above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: the weight proportion of described each raw material is---
Radix Rubiae 22-28, Euphorbia fischeriana S teud 32-38, Radix Achyranthis Bidentatae 22-28, Arisaema Cum Bile 12-22, Radix Scutellariae 42-48, Flos Inulae 22-28, Radix Glycyrrhizae Preparata 6-18, Radix Astragali 42-58, Rhizoma Smilacis Glabrae 32-38, Rhizoma Polygoni Cuspidati 42-48, Radix Aconiti Lateralis Preparata 52-58, Herba Artemisiae Scopariae 32-38, Radix Morindae Officinalis 32-38, Fructus Schisandrae Chinensis 12-15, Rhizoma Atractylodis Macrocephalae 12-18, Herba Scutellariae Barbatae 22-28, Herba Asari 6-12, Ramulus Cinnamomi 32-48, Radix Sophorae Tonkinensis 32-38, Fructus Trichosanthis 32-38, Rhizoma Anemarrhenae 22-28, Radix Notoginseng 22-28, Radix Salviae Miltiorrhizae 32-38, Radix Angelicae Sinensis 32-38, Flos Lonicerae 32-38, Herba Phyllanthi Urinariae 42-48, Cortex Eucommiae 22-28, rhizoma sparganic 32-38, Rhizoma Curcumae 32-38, Rhizoma Curcumae Longae 32-38, Fructus Toosendan 32-38, Radix Morindae Officinalis 32-38, Scorpio 22-28, Radix Codonopsis 32-38, Herba Ephedrae 12-18, Radix Sophorae Flavescentis 22-28, Radix Et Rhizoma Rhei 22-28, Radix Polygoni Multiflori 22-28, Semen Coicis 32-38, Placenta Hominis 22-28, Lignum Cudraniae tricuspidatae 22-28, Ganoderma 22-28, Bulbus Fritillariae Uninbracteatae 22-28, Spica Prunellae 22-28, Fructus Crataegi 22-28, Herba Epimedii 32-38, Herba Andrographis 22-28, Concha Ostreae 22-28, Radix Bupleuri 32-38, Radix Asparagi 22-28, Semen Plantaginis 22-28, Cortex Mori 22-28, Fructus Mori 22-28, Herba Solani Nigri 22-28, Squama Manis 22-28, Rhizoma Chuanxiong 22-28, Rhizoma Pinelliae 42-48, Myrrha 22-28, Herba Cistanches 22-28, Hedyotidis Diffusae 22-28, field dobber 22-28, Radix Rehmanniae 22-28, Radix Arnebiae (Radix Lithospermi) 22-28, Flos Carthami 22-28, Fructus Ligustri Lucidi 22-28, Rhizoma Polygonati 22-28, Herba Violae 22-28, Semen Lablab Album 22-28, Polyporus 22-28, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 22-28, Gekko Swinhonis 12-22, Radix Et Caulis Acanthopanacis Senticosi 22-28, Bombyx Batryticatus 22-28, Rhizoma Dioscoreae Bulbiferae 22-28, Endothelium Corneum Gigeriae Galli 22-28, Caulis Spatholobi 25-32, Pheretima 22-28, Pericarpium Arecae 12-22, Radix Tripterygii Wilfordii 28-32.
Further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: the weight proportion of described each raw material is---
Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, Lignum Cudraniae tricuspidatae 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
Further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: said ingredient is rich in organic selenium, the present invention prescription is subdivided into early, in, at dusk, midnight, the late into the night five prescriptions, each prescription is no more than 20 flavor Chinese medicines, take in four time periods of every day respectively by midnight-noon and ebb-flow doctrine energy and blood of human body flowing law, by different time stick at body local skin, acupuncture point administration Transdermal absorption treatment.
Again further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: the dosage form of this anti-AIDS nanometer Chinese medicine is tablet, pill, powder, suppository, granule, membrane, capsule, microcapsule, effervescent, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution, plaster.
A kind of production method of anti-tumor nano Chinese medicine, it may further comprise the steps:
Step 1: pretreatment, get the common Chinese decoction pieces of respectively distinguishing the flavor of, each flavor Chinese medicine is inserted pulverizer respectively be crushed to the 80-200 order, obtain various Chinese medicine coarse powder, carry out particle screen selecting simultaneously, the excessive secondary that carries out of granule is pulverized;
Step 2: extract pulverizing with high-frequency ultrasonic, process route is: ultrasonic power: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-50 minute;
Step 3: carry out various medicines with microwave extracting and propose extraction, microwave power is set under the 40-80% (1000 watts of peak powers), makes solvent with 38%--45% ethanol, and solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second;
Step 4: contain the liquid medicinal residues and adopt conventional Chinese medicine extraction percolation squeezing and pressing method to extract;
Step 5: the extracting solution after concentrating adopts supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size;
Step 6: the swing nanon ball-mill with independent research ground 4-16 hour, and obtaining particle size distribution is the nanometer Chinese medicine of 40-500 nanometer;
Step 7: in GMP10000 level toilet, the above-mentioned prepared slices of Chinese crude drugs or nanometer powder are mixed by described Billy;
Step 8: in GMP10000 level toilet, make aforementioned various preparations such as capsule, tablet by version Chinese Pharmacopoeia second portion standard preparation standard in 2005;
Step 9: each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning;
Step 10: packaged product is transported to by production batch specifies cobalt 60 irradiation centers to unify irradiation sterilization, and opens the sterilization report;
Above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: described step 2 is being carried out in the leaching process with high-frequency ultrasonic, can carry out the dispersion and the pulverizing of powder simultaneously.
Further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: described step 3 is carried out various medicines with microwave extracting and is carried when extraction, can collect volatile active substance in the medicine simultaneously.
Further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: described step 6 is carried out nano-milled with the swing nanon ball-mill of independent research, is with the powder ball grinder of bacterium of going out of packing into, grinds 4～16 hours with the nano double planetary ball mill.60～90 degrees centigrade the high temperature that produces when grinding with the swing nanon ball-mill of independent research simultaneously, can carry out high temperature sterilize to raw material.
Again further, above-mentioned a kind of anti-tumor nano Chinese medicine, wherein: described step 7 is mixed the above-mentioned prepared slices of Chinese crude drugs or nanometer powder in GMP10000 level toilet by the described Billy of prescription.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in: the present invention adopts sun greater than cloudy theoretical research and development anti-tumor nano Chinese medicine, prove the present domestic reported literature that has the utilization sun to research and develop the nanometer tcm product greater than cloudy theory of not seeing according to the novelty assessment report conclusion.This prescription is to adopt sun to make main dialectical opinion greater than cloudy theory to control method, pays attention to the collaborative idea of human body integral, pays attention to selenium-enriched nano medicine Synergistic treatment scheme.Emphasize that the vital organs of the human body, the four stages in the course of an epidemic febrile disease, body fluid marrow are in harmonious proportion with mending, the cold warm medicine of a cold nature of heat and with, inside and outside administration develop simultaneously, the midnight-noon and ebb-flow doctrine QI and blood flows to the position medication of timesharing branch.This prescription is by setting upright timid heresy, monarch reasonable compatibility etc., that the Chinese medicine of will filling a prescription is divided into is early, middle and late, midnight, the late into the night five prescriptions, each prescription is no more than 20 flavor Chinese medicines, takes five time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Nanometer Chinese medicine is made plaster be attached to the affected part, can and need not inject, strengthened single variety antiviral antineoplastic ability and biological activity behind the prescription nanorize, reach the purpose of enhancing immunity, raising human body antiviral anti-tumor capacity by the direct absorption of skin.This prescription is taken for a long time and is had no side effect, be fit to various crowd's enhancing immunity, improve human body antiviral anti-tumor capacity, various tumor patients, viral infection patient are all had therapeutical effect, and the mode of production has then been gathered the integration that high-frequency ultrasonic extracts advanced technologies such as disperseing crushing technology, microwave extracting technology of preparing, supersonic speed dry technology, the grinding of efficient physical nanoscale.The prescription theory is to be based upon on the rationale such as a large amount of traditional Chinese medical science works, pharmacology of Chinese materia medica, pharmacodynamics, toxicology, biotechnology, modern pharmaceutical technology, nanotechnology, is many interdisciplinary technology set.This shows that the present invention has substantive technical characterstic and significant technological progress, its application prospect is boundless.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
A kind of anti-tumor nano Chinese medicine, its special feature is: making the raw materials of effective components composition is by weight ratio---Radix Rubiae 20-30, Euphorbia fischeriana S teud 30-40, Radix Achyranthis Bidentatae 23-30, Arisaema Cum Bile 15-25, Radix Scutellariae 40-50, Flos Inulae 20-30, Radix Glycyrrhizae Preparata 5-20, Radix Astragali 40-60, Rhizoma Smilacis Glabrae 30-40, Rhizoma Polygoni Cuspidati 40-50, Radix Aconiti Lateralis Preparata 50-60, Herba Artemisiae Scopariae 30-40, Radix Morindae Officinalis 30-40, Fructus Schisandrae Chinensis 10-20, Rhizoma Atractylodis Macrocephalae 10-20, Herba Scutellariae Barbatae 20-30, Herba Asari 6-15, Ramulus Cinnamomi 30-40, Radix Sophorae Tonkinensis 30-40, Fructus Trichosanthis 30-40, Rhizoma Anemarrhenae 20-30, Radix Notoginseng 20-30, Radix Salviae Miltiorrhizae 30-40, Radix Angelicae Sinensis 30-40, Flos Lonicerae 30-40, Herba Phyllanthi Urinariae 40-50, Cortex Eucommiae 20-30, rhizoma sparganic 30-40, Rhizoma Curcumae 30-40, Rhizoma Curcumae Longae 30-40, Fructus Toosendan 30-40, Radix Morindae Officinalis 30-40, Scorpio 20-30, Radix Codonopsis 30-40, Herba Ephedrae 10-20, Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Polygoni Multiflori 20-30, Semen Coicis 30-40, Placenta Hominis 20-30, Lignum Cudraniae tricuspidatae 20-30, Ganoderma 20-30, Bulbus Fritillariae Uninbracteatae 20-30, Spica Prunellae 20-30, Fructus Crataegi 20-30, Herba Epimedii 30-40, Herba Andrographis 20-30, Concha Ostreae 20-30, Radix Bupleuri 30-40, Radix Asparagi 20-30, Semen Plantaginis 20-30, Cortex Mori 20-30, Fructus Mori 20-30, Herba Solani Nigri 20-30, Squama Manis 20-30, Rhizoma Chuanxiong 20-30, Rhizoma Pinelliae 40-50, Myrrha 20-30, Herba Cistanches 20-30, Hedyotidis Diffusae 20-30, field dobber 20-30, Radix Rehmanniae 20-30, Radix Arnebiae (Radix Lithospermi) 20-30, Flos Carthami 20-30, Fructus Ligustri Lucidi 20-30, Rhizoma Polygonati 20-30, Herba Violae 20-30, Semen Lablab Album 20-30, Polyporus 20-30, Herba Taraxaci 20-30, Hirudo 20-30, Rhizoma Curculiginis 20-30, Rhizoma Dioscoreae 20-30, Cortex Eucommiae 20-30, Eupolyphaga Seu Steleophaga 15-25, Resina garciniae 20-30, Gekko Swinhonis 10-25, Radix Et Caulis Acanthopanacis Senticosi 20-30, Bombyx Batryticatus 20-30, Rhizoma Dioscoreae Bulbiferae 20-30, Endothelium Corneum Gigeriae Galli 20-30, Caulis Spatholobi 25-35, Pheretima 20-30, Pericarpium Arecae 10-25, Radix Tripterygii Wilfordii 25-35.
With regard to the present invention's one preferred embodiment, described each raw material can adopt following weight proportion: Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, Lignum Cudraniae tricuspidatae 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
Again further, solid preparation of the present invention can be fast in the gastrointestinal disintegrate, in water, in the body solid dispersion good, absorb rapidly fully, bioavailability is good, stronger targeting and tunneling are arranged, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention, may further comprise the steps: at first, adopt high-frequency ultrasonic to extract to pulverize and add the microwave extracting mode and carry out medicine and propose extraction, process route is: adopt high-frequency ultrasonic to extract earlier and pulverize, ultrasonic power: 800W-3000W, supersonic frequency: 28KHz--120KHz, pulverizing extraction time is 10-50 minute, carry out microwave extracting then, microwave power is set under the 40--80% (1000 watts of peak powers), make solvent with 38%-45% ethanol, solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second.Then will contain the liquid medicinal residues and adopt conventional Chinese medicine extraction percolation squeezing and pressing method to extract, extracting solution adopts supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size after concentrating.
Adopt the swing nanon ball-mill of independent research to grind then 4-16 hour, obtaining particle size distribution is the nanometer Chinese medicine of 40-500 nanometer, mix in GMP10000 level toilet by version Chinese Pharmacopoeia second portion standard preparation standard in 2005 at last, make aforementioned various preparations such as capsule, tablet.After finishing, Production and Packaging get final product to specifying cobalt 60 irradiation centers to unify sterilization by production batch.
" embodiment one "
Prepare nano raw material by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, Lignum Cudraniae tricuspidatae 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
Its manufacture process is as follows:
After in the GMP10000 level toilet Nano Chinese medicine powder agent or the prepared slices of Chinese crude drugs being mixed according to the above ratio, adopt version Chinese Pharmacopoeia second portion preparation capsule standard in 2005, do not add adjuvant, antiseptic, do not granulate, it is encapsulated to adopt the fully-automatic capsule filling machine to divide, and makes capsule.After finishing, Production and Packaging unify sterilization to appointment cobalt 60 irradiation centers by production batch.Every content of dispersion is the 0.2-0.6 gram, and the patient takes the 1-6 grain at every turn, and respectively obey 1 early, middle and late, night every day.
" embodiment two "
Prepare nano raw material by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, three-bristle cudrania art 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
Its manufacture process is as follows:
After in the GMP10000 level toilet Nano Chinese medicine powder agent or the prepared slices of Chinese crude drugs being mixed according to the above ratio, adopt version Chinese Pharmacopoeia second portion preparation tablet standard in 2005, do not add adjuvant, antiseptic, adopt full-automatic tablet machine, make tablet.After finishing, Production and Packaging unify sterilization to appointment cobalt 60 irradiation centers by production batch.Every content of dispersion is the 0.2-1.2 gram, and the patient takes the 1-5 sheet at every turn, and respectively obey 1 early, middle and late, night every day.
" embodiment three "
Prepare nano raw material by preceding method: it is made raw materials of effective components and forms and to be by weight ratio---Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, Lignum Cudraniae tricuspidatae 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
Its manufacture process is as follows:
After in the GMP10000 level toilet Nano Chinese medicine powder agent or the prepared slices of Chinese crude drugs being mixed according to the above ratio, adopt version Chinese Pharmacopoeia second portion preparation membrane standard in 2005, filmogen adopts polyvinyl alcohol, make medicine film in the nanometer, every membrane area size is the 1-98 square centimeter, content of dispersion is the 1.2-55 gram, and every medicine film pasted 12-96 hour, pasted the medicine position: acupuncture points such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
Claims (10)
1. anti-tumor nano Chinese medicine is characterized in that: this prescription raw materials of effective components and weight proportion---
Radix Rubiae 20-30, Euphorbia fischeriana S teud 30-40, Radix Achyranthis Bidentatae 23-30, Arisaema Cum Bile 15-25, Radix Scutellariae 40-50, Flos Inulae 20-30, Radix Glycyrrhizae Preparata 5-20, Radix Astragali 40-60, Rhizoma Smilacis Glabrae 30-40, Rhizoma Polygoni Cuspidati 40-50, Radix Aconiti Lateralis Preparata 50-60, Herba Artemisiae Scopariae 30-40, Radix Morindae Officinalis 30-40, Fructus Schisandrae Chinensis 10-20, Rhizoma Atractylodis Macrocephalae 10-20, Herba Scutellariae Barbatae 20-30, Herba Asari 6-15, Ramulus Cinnamomi 30-40, Radix Sophorae Tonkinensis 30-40, Fructus Trichosanthis 30-40, Rhizoma Anemarrhenae 20-30, Radix Notoginseng 20-30, Radix Salviae Miltiorrhizae 30-40, Radix Angelicae Sinensis 30-40, Flos Lonicerae 30-40, Herba Phyllanthi Urinariae 40-50, Cortex Eucommiae 20-30, rhizoma sparganic 30-40, Rhizoma Curcumae 30-40, Rhizoma Curcumae Longae 30-40, Fructus Toosendan 30-40, Radix Morindae Officinalis 30-40, Scorpio 20-30, Radix Codonopsis 30-40, Herba Ephedrae 10-20, Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Polygoni Multiflori 20-30, Semen Coicis 30-40, Placenta Hominis 20-30, Lignum Cudraniae tricuspidatae 20-30, Ganoderma 20-30, Bulbus Fritillariae Uninbracteatae 20-30, Spica Prunellae 20-30, Fructus Crataegi 20-30, Herba Epimedii 30-40, Herba Andrographis 20-30, Concha Ostreae 20-30, Radix Bupleuri 30-40, Radix Asparagi 20-30, Semen Plantaginis 20-30, Cortex Mori 20-30, Fructus Mori 20-30, Herba Solani Nigri 20-30, Squama Manis 20-30, Rhizoma Chuanxiong 20-30, Rhizoma Pinelliae 40-50, Myrrha 20-30, Herba Cistanches 20-30, Hedyotidis Diffusae 20-30, field dobber 20-30, Radix Rehmanniae 20-30, Radix Arnebiae (Radix Lithospermi) 20-30, Flos Carthami 20-30, Fructus Ligustri Lucidi 20-30, Rhizoma Polygonati 20-30, Herba Violae 20-30, Semen Lablab Album 20-30, Polyporus 20-30, Herba Taraxaci 20-30, Hirudo 20-30, Rhizoma Curculiginis 20-30, Rhizoma Dioscoreae 20-30, Cortex Eucommiae 20-30, Eupolyphaga Seu Steleophaga 15-25, Resina garciniae 20-30, Gekko Swinhonis 10-25, Radix Et Caulis Acanthopanacis Senticosi 20-30, Bombyx Batryticatus 20-30, Rhizoma Dioscoreae Bulbiferae 20-30, Endothelium Corneum Gigeriae Galli 20-30, Caulis Spatholobi 25-35, Pheretima 20-30, Pericarpium Arecae 10-25, Radix Tripterygii Wilfordii 25-35.
2. a kind of anti-tumor nano Chinese medicine according to claim 1 is characterized in that: the weight proportion of described each raw material is---
Radix Rubiae 22-28, Euphorbia fischeriana S teud 32-38, Radix Achyranthis Bidentatae 22-28, Arisaema Cum Bile 12-22, Radix Scutellariae 42-48, Flos Inulae 22-28, Radix Glycyrrhizae Preparata 6-18, Radix Astragali 42-58, Rhizoma Smilacis Glabrae 32-38, Rhizoma Polygoni Cuspidati 42-48, Radix Aconiti Lateralis Preparata 52-58, Herba Artemisiae Scopariae 32-38, Radix Morindae Officinalis 32-38, Fructus Schisandrae Chinensis 12-15, Rhizoma Atractylodis Macrocephalae 12-18, Herba Scutellariae Barbatae 22-28, Herba Asari 6-12, Ramulus Cinnamomi 32-48, Radix Sophorae Tonkinensis 32-38, Fructus Trichosanthis 32-38, Rhizoma Anemarrhenae 22-28, Radix Notoginseng 22-28, Radix Salviae Miltiorrhizae 32-38, Radix Angelicae Sinensis 32-38, Flos Lonicerae 32-38, Herba Phyllanthi Urinariae 42-48, Cortex Eucommiae 22-28, rhizoma sparganic 32-38, Rhizoma Curcumae 32-38, Rhizoma Curcumae Longae 32-38, Fructus Toosendan 32-38, Radix Morindae Officinalis 32-38, Scorpio 22-28, Radix Codonopsis 32-38, Herba Ephedrae 12-18, Radix Sophorae Flavescentis 22-28, Radix Et Rhizoma Rhei 22-28, Radix Polygoni Multiflori 22-28, Semen Coicis 32-38, Placenta Hominis 22-28, Lignum Cudraniae tricuspidatae 22-28, Ganoderma 22-28, Bulbus Fritillariae Uninbracteatae 22-28, Spica Prunellae 22-28, Fructus Crataegi 22-28, Herba Epimedii 32-38, Herba Andrographis 22-28, Concha Ostreae 22-28, Radix Bupleuri 32-38, Radix Asparagi 22-28, Semen Plantaginis 22-28, Cortex Mori 22-28, Fructus Mori 22-28, Herba Solani Nigri 22-28, Squama Manis 22-28, Rhizoma Chuanxiong 22-28, Rhizoma Pinelliae 42-48, Myrrha 22-28, Herba Cistanches 22-28, Hedyotidis Diffusae 22-28, field dobber 22-28, Radix Rehmanniae 22-28, Radix Arnebiae (Radix Lithospermi) 22-28, Flos Carthami 22-28, Fructus Ligustri Lucidi 22-28, Rhizoma Polygonati 22-28, Herba Violae 22-28, Semen Lablab Album 22-28, Polyporus 22-28, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 18-22, Resina garciniae 22-28, Gekko Swinhonis 12-22, Radix Et Caulis Acanthopanacis Senticosi 22-28, Bombyx Batryticatus 22-28, Rhizoma Dioscoreae Bulbiferae 22-28, Endothelium Corneum Gigeriae Galli 22-28, Caulis Spatholobi 25-32, Pheretima 22-28, Pericarpium Arecae 12-22, Radix Tripterygii Wilfordii 28-32.
3. a kind of anti-tumor nano Chinese medicine according to claim 1 is characterized in that: the weight proportion of described each raw material is---
Radix Rubiae 25, Euphorbia fischeriana S teud 35, Radix Achyranthis Bidentatae 25, Arisaema Cum Bile 12, Radix Scutellariae 42, Flos Inulae 25, Radix Glycyrrhizae Preparata 8, the Radix Astragali 58, Rhizoma Smilacis Glabrae 35, Rhizoma Polygoni Cuspidati 45, Radix Aconiti Lateralis Preparata 55, Herba Artemisiae Scopariae 35, Radix Morindae Officinalis 35, Fructus Schisandrae Chinensis 12, the Rhizoma Atractylodis Macrocephalae 15, Herba Scutellariae Barbatae 25, Herba Asari 8, Ramulus Cinnamomi 35, Radix Sophorae Tonkinensis 35, Fructus Trichosanthis 35, the Rhizoma Anemarrhenae 25, Radix Notoginseng 25, Radix Salviae Miltiorrhizae 35, Radix Angelicae Sinensis 35, Flos Lonicerae 35, Herba Phyllanthi Urinariae 45, the Cortex Eucommiae 25, rhizoma sparganic 35, Rhizoma Curcumae 35, Rhizoma Curcumae Longae 35, Fructus Toosendan 35, Radix Morindae Officinalis 35, Scorpio 25, Radix Codonopsis 35, Herba Ephedrae 15, Radix Sophorae Flavescentis 25, Radix Et Rhizoma Rhei 25, Radix Polygoni Multiflori 25, Semen Coicis 35, Placenta Hominis 25, Lignum Cudraniae tricuspidatae 25, Ganoderma 25, Bulbus Fritillariae Uninbracteatae 25, Spica Prunellae 25, Fructus Crataegi 25, Herba Epimedii 35, Herba Andrographis 25, Concha Ostreae 25, Radix Bupleuri 35, Radix Asparagi 25, Semen Plantaginis 25, Cortex Mori 25, Fructus Mori 25, Herba Solani Nigri 25, Squama Manis 25, Rhizoma Chuanxiong 25, the Rhizoma Pinelliae 45, Myrrha 25, Herba Cistanches 25, Hedyotidis Diffusae 25, field dobber 25, Radix Rehmanniae 25, Radix Arnebiae (Radix Lithospermi) 25, Flos Carthami 25, Fructus Ligustri Lucidi 25, Rhizoma Polygonati 25, Herba Violae 25, Semen Lablab Album 25, Polyporus 25, Herba Taraxaci 22-28, Hirudo 22-28, Rhizoma Curculiginis 22-28, Rhizoma Dioscoreae 22-28, Cortex Eucommiae 22-28, Eupolyphaga Seu Steleophaga 1822, Resina garciniae 25, Gekko Swinhonis 15, Radix Et Caulis Acanthopanacis Senticosi 25, Bombyx Batryticatus 25, Rhizoma Dioscoreae Bulbiferae 25, Endothelium Corneum Gigeriae Galli 25, Caulis Spatholobi 30, Pheretima 25, Pericarpium Arecae 15, Radix Tripterygii Wilfordii 30.
4. according to claim 1 or 2 or 3 any described a kind of anti-tumor nano Chinese medicines, it is characterized in that: adopt sun greater than cloudy theoretical this prescription of research and development, said pharmaceutical formulation is tablet, pill, powder, suppository, granule, membrane, capsule, microcapsule, effervescent, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution, plaster.
5. according to claim 1 or 2 or 3 any described a kind of anti-tumor nano Chinese medicines, it is characterized in that: said medicine is rich in organic selenium, the present invention prescription is subdivided into early, in, at dusk, midnight, the late into the night five division of day and night prescriptions, each prescription is no more than 20 flavor Chinese medicines, take in five time periods of every day respectively by midnight-noon and ebb-flow doctrine energy and blood of human body flowing law, by different time stick at body local skin, acupuncture point administration Transdermal absorption treatment.
6. the production method of an anti-tumor nano Chinese medicine is characterized in that may further comprise the steps:
Step 1: pretreatment, get the common Chinese decoction pieces of respectively distinguishing the flavor of, each flavor Chinese medicine is inserted pulverizer respectively be crushed to the 80-200 order, obtain various Chinese medicine coarse powder, carry out particle screen selecting simultaneously, the excessive secondary that carries out of granule is pulverized;
Step 2: extract pulverizing with high-frequency ultrasonic, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute;
Step 3: carry out various medicines with microwave extracting and propose extraction, microwave power is set under the 40-80% (1000 watts of peak powers), makes solvent with 38%--45% ethanol, and solvent 25-35 doubly measures, pressure 0.10-0.25Mpa, constant voltage time 30-60 can obtain dissolution rate preferably second;
Step 4: contain the liquid medicinal residues and adopt conventional Chinese medicine extraction percolation squeezing and pressing method to extract;
Step 5: the extracting solution after concentrating adopts supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) spray drying to be crushed to the 1-5 micron grain size,
Step 6: the swing nanon ball-mill with independent research ground 4-16 hour, and obtaining particle size distribution is the nanometer Chinese medicine of 40-500 nanometer;
Step 7: in GMP10000 level toilet, the above-mentioned prepared slices of Chinese crude drugs or nanometer powder are mixed by described Billy;
Step 8: in GMP10000 level toilet, make aforementioned various preparations such as capsule, tablet by version Chinese Pharmacopoeia second portion standard preparation standard in 2005;
Step 9: each formulation products is pasted labeling respectively, played exterior and interior packings such as sign indicating number, vanning;
Step 10: packaged product is transported to by production batch specifies cobalt 60 irradiation centers to unify irradiation sterilization, and opens the sterilization report;
7. the production method of a kind of anti-tumor nano Chinese medicine according to claim 6 is characterized in that: described step 2 is being carried out in the leaching process with high-frequency ultrasonic, can carry out the dispersion and the pulverizing of powder simultaneously.
8. the production method of a kind of anti-tumor nano Chinese medicine according to claim 7 is characterized in that: described step 3 is carried out various medicines with microwave extracting and is carried when extraction, can collect volatile active substance in the medicine simultaneously.
9. the production method of a kind of anti-tumor nano Chinese medicine according to claim 8, it is characterized in that: described step 6 is carried out nano-milled with the swing nanon ball-mill of independent research, be with the powder ball grinder of bacterium of going out of packing into, ground 4～16 hours with swing nanon ball-mill.60～90 degrees centigrade the high temperature that produces when grinding with the swing nanon ball-mill of independent research simultaneously, can carry out high temperature sterilize to raw material.
10. the production method of a kind of anti-tumor nano Chinese medicine according to claim 9 is characterized in that: described step 7 is mixed the above-mentioned prepared slices of Chinese crude drugs or nanometer powder in GMP10000 level toilet by the described Billy of prescription.
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