CN101703695A - Compound dendrobium candidum blood-nourishing and liver-softening capsule and preparation method thereof - Google Patents
Compound dendrobium candidum blood-nourishing and liver-softening capsule and preparation method thereof Download PDFInfo
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- CN101703695A CN101703695A CN200910155277A CN200910155277A CN101703695A CN 101703695 A CN101703695 A CN 101703695A CN 200910155277 A CN200910155277 A CN 200910155277A CN 200910155277 A CN200910155277 A CN 200910155277A CN 101703695 A CN101703695 A CN 101703695A
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Abstract
The invention provides a dendrobium candidum blood-nourishing and liver-softening capsule and a preparation method thereof, wherein the dendrobium candidum blood-nourishing and liver-softening capsule takes seven types of traditional Chinese medicines of dendrobium candidum, radix rehmanniae, Chinese angelica, white paeony root, salvia miltiorrhiza bunge, barbary wolfberry fruit and adenophora stricta as raw materials. The main technique comprises the following steps: firstly crushing the radix rehmanniae and the white paeony root into powder for later use, combining and mixing evenly the extracts of the Chinese angelica, the dendrobium candidum, the barbary wolfberry fruit and the like, reducing the pressure under low temperature, drying and filling into a capsule. The invention can nourish the blood and soften the liver, and has the advantages of stable manufacture technique, simple operation, short production cycle and the like.
Description
Technical field
The invention belongs to the Medicines and Health Product field, be specifically related to a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule and preparation method thereof.
Background technology
Herba Dendrobii (Dendrobium officinale Kimura et Migo) claims again to be the orchid family Dendrobium medicinal plants by ferrum bracketplant.Herba Dendrobii is a kind of rare Chinese medicine, has except that the fraud therapeutic method to keep the adverse QI flowing downwards, and tonifying five ZANG-organs labor is won thin, and reinforcing YIN-essence is grown the effect of essence, is widely used in clinical and complex health care product.
Liver is one of most important organ of human body, and it all plays important effect at aspects such as people's metabolism, digestion, detoxifcation, blood coagulation, immunomodulating, has stored blood, regulates the function of blood volume.The blood that the partes corporis humani divides often changes blood flow in view of various physiological conditions.If liver is ill, then lose the function of store blood, will influence the normal activity of human body, the pathological changes of blood aspect also can appear simultaneously.In order to prevent that pathological changes from appearring in liver, protect the liver, hepatoprotective becomes an effective means of prevention of liver disease.The health product tool of for this reason developing a kind of compound recipe nourishing yin for softening liver effect has very important significance.
By retrieval, though, do not see the report of Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule and preparation thereof relevant for compound recipe Herba Dendrobii YIN nourishing class health product.The present invention uses the modern pharmaceutical technology exactly, develops a kind of compound capsule with nourishing YIN and benefiting blood easing the affected liver effect.
Summary of the invention
The object of the present invention is to provide a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule and preparation method thereof, come nourishing blood to suppress the hyperactive liver, YIN nourishing and QI supplementing, enhancing immunity.
A kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule mainly contains following deal component and forms: Herba Dendrobii 566-666 part, Radix Rehmanniae 59-109 part, Radix Angelicae Sinensis 159-189 part, Radix Paeoniae Alba 59-89 part, Radix Salviae Miltiorrhizae 26-59 part, Fructus Lycii 59-89 part, Radix Adenophorae (Radix Glehniae) 26-59 part.
Herba Dendrobii: go into stomach, lung, kidney three warps, can nourishing stomach-YIN, clearing heat and moistening lung, again can replenishing vital essence to improve eyesight.
The Radix Rehmanniae: energy removing heat from blood, hemostasis, yet easy obstruction transporting and transforming function of the spleen and stomach cold in nature.
Radix Angelicae Sinensis: warm in nature, hide sweet, hot; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.In blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
The Radix Paeoniae Alba: cold in nature, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Heart-liver blood deficiency and meet that color is sallow, the lip pawl is simple and unadorned, have a dizzy spell, cardiopalmus limb fiber crops.Radix Angelicae Sinensis and Radix Paeoniae Alba compatibility, the power of then enriching blood is stronger.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Radix Adenophorae (Radix Glehniae): sweet, cold.Clearing away heat and nourishing YIN, nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, the cough due to lung-heat, it is yellow thick to cough up phlegm.
The present invention is exactly the nourishing the stomach YIN nourishing that has made full use of Herba Dendrobii, the clearing heat and moistening lung effect, and with the effect of invigorating blood circulation of enriching blood of Radix Angelicae Sinensis, benefit mutually and open. with the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Fructus Lycii, the mutual compatibility of Radix Adenophorae (Radix Glehniae), have the effect of nourishing blood to suppress the hyperactive liver, can be used for the liver-yin deficiency of liver-blood, insomnia, women's scanty menorrhea or amenorrhea, lip pale tongue, deep-thready pulse.
The capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver, realize by following processing step:
(1) earlier with the Radix Rehmanniae, that the Radix Paeoniae Alba is ground into powder is standby;
(2) Radix Angelicae Sinensis is adopted alcohol reflux extract more than twice, merge alcohol extract, filter, filtrate decompression reclaims mellow, is evaporated to thick paste again;
(3) medical material water extraction such as Herba Dendrobii, Fructus Lycii more than twice, are merged aqueous extract, filter, filtrate is concentrated into thick paste;
(4) two cream are merged, add the Radix Paeoniae Alba, Radix Rehmanniae powder mixing, the low-temperature reduced-pressure drying is pulverized, sieve, and filled capsules, promptly.
The alcohol that is used for the Radix Angelicae Sinensis extraction in above-mentioned steps is ethanol, and concentration is 70%-90%.
The relative density of Radix Angelicae Sinensis thick paste can be 1.20-1.35 (50 ℃) in above-mentioned steps.
The relative density of Fructus Lycii, Radix Adenophorae (Radix Glehniae), Radix Salviae Miltiorrhizae thick paste is 1.10-1.35 (80 ℃) in above-mentioned steps.
In above-mentioned steps the low-temperature reduced-pressure drying can be≤-0.06MPA, 45 ℃ of-70 ℃ of drying under reduced pressure.
Above-mentionedly do not walk middle pulverizing, sieve, filled capsules also can make and be ground into powder, cross 40-80 mesh sieve, filled capsules.
The main technique step that the capsular preparation method of nourishing blood to suppress the hyperactive liver of the present invention is adopted is saved the solvent and the energy, and process stabilizing is simple to operate, with short production cycle.Adopt the low-temperature vacuum drying technology, keep the Chinese medicine active ingredient, more allow stable and controllable for qualityly, can guarantee curative effect.Has little, the suitable crowd of the volume of taking advantage widely.
The toxicologic study checking
Acute toxicity test: disposable filling stomach 45% Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule medicinal liquid 40ml/kg in the Kunming mouse 24h, (Cmax, maximum volume), promptly contain iron sheet Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule crude drug in whole 44g/kg, be equivalent to 240 times of the clinical daily dosage of people, no animal dead and whole body toxicity.Results suggest, the nourishing blood to suppress the hyperactive liver capsule is taken safety in effective dose.
Long term toxicity test:, Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule is carried out the rat long term toxicity test according to the requirement of Ministry of Public Health " new Chinese medicine toxicologic study guide ".Result: rat oral gavage 5% Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule medicinal liquid 15ml/kgd
-1(1.84g crude drug in whole/kg is equivalent to 10 times of the clinical consumptions of people), 15% Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule medicinal liquid 15ml/kgd
-1(5.5lg, crude drug in whole/kg are equivalent to 30 times of clinical consumption), 45% Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule Pharmaceutical 15ml/kgd
-1(16.5g crude drug in whole, kg, be equivalent to 90 times of the clinical consumption of people), continuous 8 weeks, general states such as animal food-intake, body weight, outward appearance sign and behavioral activity are normal, hematological indices (RBC, HB, PLT, WBC, N, L, E), blood parameters (GPT, TCHO, TP, ALB, Grea, Bun), system become celestial and mainly hide organ (heart, liver, spleen, lung, kidney, adrenal gland, thymus, ovary, uterus, testis) histopathological examination, do not see significant toxicity; Reversibility is observed, no abnormality seen.Results suggest, Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule are in effective dose and effectively use safety in the course of treatment.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following embodiment only is used to illustrate the present invention, but to not restriction of the present invention.
Embodiment one
According to the per 1000 granulated iron skin Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule Herba Dendrobii 566g of preparation, Radix Rehmanniae 59g, Radix Angelicae Sinensis 159g, Radix Paeoniae Alba 59g, Radix Salviae Miltiorrhizae 26g, Fructus Lycii 59g, Radix Adenophorae (Radix Glehniae) 26g weight part ratio takes by weighing raw material. and the Radix Rehmanniae, the Radix Paeoniae Alba are pulverized beat powder, it is standby to cross 80 mesh sieves.
Radix Angelicae Sinensis adds 8 times of amount 80% ethanol, reflux, extract, twice, and each 1 hour, merge alcohol extract, filter, decompression filtrate recycling ethanol is evaporated to the thick paste of relative density 1.30 (50 ℃).
Radix Salviae Miltiorrhizae, Fructus Lycii, Radix Adenophorae (Radix Glehniae), Herba Dendrobii add 8 times of water gagings, and reflux, extract, twice is 2.5h for the first time, and 1.5h merges the water extract for the second time, filters, and is concentrated into the thick paste of relative density 1.28 (80 ℃).
Two cream merge, and add the Radix Paeoniae Alba, Radix Rehmanniae fine powder, mixing, the low-temperature reduced-pressure drying (50 ℃ ,≤-0.06Mpa) become dried cream, after the pulverizing, cross 60 mesh sieves, filled capsules, promptly.
Embodiment two
According to the per 1000 granulated iron skin Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule Herba Dendrobii 586g of preparation, Radix Rehmanniae 69g, Radix Angelicae Sinensis 179g, Radix Paeoniae Alba 79g, Radix Salviae Miltiorrhizae 46g, Fructus Lycii 79g, Radix Adenophorae (Radix Glehniae) 46g weight part ratio takes by weighing raw material.Powder is beaten in the Radix Rehmanniae, Radix Paeoniae Alba pulverizing, and it is standby to cross 60 mesh sieves.
Radix Angelicae Sinensis adds 5 times of amount 90% ethanol, reflux, extract, twice, and each 1 hour, merge alcohol extract, filter, decompression filtrate recycling ethanol is evaporated to the thick paste of relative density 1.30 (50 ℃).
Radix Salviae Miltiorrhizae, Fructus Lycii, Radix Adenophorae (Radix Glehniae), Herba Dendrobii add 8 times of water gagings, and reflux, extract, twice is 2.5h for the first time, and 1.5h merges the water extract for the second time, filters, and is concentrated into the thick paste of relative density 1.32 (80 ℃).
Two cream merge, and add the Radix Paeoniae Alba, Radix Rehmanniae fine powder, mixing, the low-temperature reduced-pressure drying (50 ℃ ,≤-0.07Mpa) become dried cream, after the pulverizing, cross 60 mesh sieves, filled capsules, promptly.
Embodiment three
According to the per 1000 granulated iron skin Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule Herba Dendrobii 666g of preparation, Radix Rehmanniae 109g, Radix Angelicae Sinensis 189g, Radix Paeoniae Alba 89g, Radix Salviae Miltiorrhizae 59g, Fructus Lycii 89g, Radix Adenophorae (Radix Glehniae) 59g weight part ratio takes by weighing raw material.Powder is beaten in the Radix Rehmanniae, Radix Paeoniae Alba pulverizing, and it is standby to cross 50 mesh sieves.
Radix Angelicae Sinensis adds 10 times of amount 70% ethanol, reflux, extract, twice, and each 1 hour, merge alcohol extract, filter, decompression filtrate recycling ethanol is evaporated to the thick paste of relative density 1.42 (50 ℃).
Radix Salviae Miltiorrhizae, Fructus Lycii, Radix Adenophorae (Radix Glehniae), Herba Dendrobii add 8 times of water gagings, and reflux, extract, twice is 2.5h for the first time, and 1.5h merges the water extract for the second time, filters, and is concentrated into the thick paste of relative density 1.45 (80 ℃).
Two cream merge, and add the Radix Paeoniae Alba, Radix Rehmanniae fine powder, mixing, the low-temperature reduced-pressure drying (50 ℃ ,≤-0.08Mpa) become dried cream, after the pulverizing, cross 40 mesh sieves, filled capsules, promptly.
Claims (7)
1. a compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver capsule is characterized in that, is made up of following components by weight percent: Herba Dendrobii 566-666 part, Radix Rehmanniae 59-109 part, Radix Angelicae Sinensis 159-189 part, Radix Paeoniae Alba 59-89 part, Radix Salviae Miltiorrhizae 26-59 part, Fructus Lycii 59-89 part, Radix Adenophorae (Radix Glehniae) 26-59 part seven flavor Chinese medicines are formed.
2. the capsular preparation method of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver is characterized in that, comprises following steps:
(1) earlier with the Radix Rehmanniae, that the Radix Paeoniae Alba is ground into powder is standby;
(2) Radix Angelicae Sinensis is adopted alcohol reflux extract more than twice, merge alcohol extract, filter, filtrate decompression reclaims mellow, is evaporated to thick paste again;
(3) medical material water extraction such as Herba Dendrobii, Fructus Lycii more than twice, are merged aqueous extract, filter, filtrate is concentrated into thick paste;
(4) two cream are merged, add the Radix Paeoniae Alba, Radix Rehmanniae powder mixing, the low-temperature reduced-pressure drying is pulverized, sieve, and filled capsules, promptly.
3. as the capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver as described in the claim 2, it is characterized in that: being used for the alcohol that Radix Angelicae Sinensis extracts in the step (2) in above-mentioned steps is ethanol, and concentration is 70%-90%.
4. as the capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver as described in the claim 2, it is characterized in that: the relative density at Radix Angelicae Sinensis thick paste in above-mentioned steps in the step (3) can be 1.20-1.35 (50 ℃).
5. as the capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver as described in the claim 2, it is characterized in that: the relative density at Fructus Lycii in above-mentioned steps, Radix Adenophorae (Radix Glehniae), Radix Salviae Miltiorrhizae thick paste in the step (4) is 1.10-1.35 (80 ℃).
6. as the capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver as described in the claim 2, it is characterized in that: in the step (2) in the step low-temperature reduced-pressure drying can be≤-0.06MPA, 45 ℃ of-70 ℃ of drying under reduced pressure.
7. as the capsular preparation method of a kind of compound recipe Herba Dendrobii nourishing blood to suppress the hyperactive liver as described in the claim 2, it is characterized in that: in the step (2) in middle pulverizing, sieving was meant 40-80 mesh sieve, filled capsules.
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| CN200910155277A CN101703695A (en) | 2009-12-09 | 2009-12-09 | Compound dendrobium candidum blood-nourishing and liver-softening capsule and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971941A (en) * | 2010-09-10 | 2011-02-16 | 芮旭婷 | Preparation method of composite dendrobe health-care product |
| CN103181431A (en) * | 2012-06-06 | 2013-07-03 | 严丰丽 | Liver-nourishing health protection tea and preparation method |
| CN104818191A (en) * | 2015-03-11 | 2015-08-05 | 常州展华机器人有限公司 | Dendrobium officinale health wine and preparation method thereof |
| CN105077232A (en) * | 2015-06-12 | 2015-11-25 | 浙江仙人草保健品有限公司 | Dendrobium officinale and fructus lycii capsule and preparation method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN105796819A (en) * | 2016-05-05 | 2016-07-27 | 广东福寿仙生物科技有限公司 | Immunomodulating selenium-rich Chinese herbal medicine composition containing compound polysaccharide and preparation |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN108902965A (en) * | 2018-06-12 | 2018-11-30 | 中肽生物科技（深圳）有限公司 | One kind is enriched blood compound peptide functional food and preparation method thereof |
-
2009
- 2009-12-09 CN CN200910155277A patent/CN101703695A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971941A (en) * | 2010-09-10 | 2011-02-16 | 芮旭婷 | Preparation method of composite dendrobe health-care product |
| CN103181431A (en) * | 2012-06-06 | 2013-07-03 | 严丰丽 | Liver-nourishing health protection tea and preparation method |
| CN103181431B (en) * | 2012-06-06 | 2014-09-10 | 严丰丽 | Liver-nourishing health protection tea and preparation method |
| CN104818191A (en) * | 2015-03-11 | 2015-08-05 | 常州展华机器人有限公司 | Dendrobium officinale health wine and preparation method thereof |
| CN105077232A (en) * | 2015-06-12 | 2015-11-25 | 浙江仙人草保健品有限公司 | Dendrobium officinale and fructus lycii capsule and preparation method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN105796819A (en) * | 2016-05-05 | 2016-07-27 | 广东福寿仙生物科技有限公司 | Immunomodulating selenium-rich Chinese herbal medicine composition containing compound polysaccharide and preparation |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN108902965A (en) * | 2018-06-12 | 2018-11-30 | 中肽生物科技（深圳）有限公司 | One kind is enriched blood compound peptide functional food and preparation method thereof |
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Application publication date: 20100512 |