CN101623306B - Bracken pill and preparation method thereof - Google Patents
Bracken pill and preparation method thereof Download PDFInfo
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- CN101623306B CN101623306B CN2008101296604A CN200810129660A CN101623306B CN 101623306 B CN101623306 B CN 101623306B CN 2008101296604 A CN2008101296604 A CN 2008101296604A CN 200810129660 A CN200810129660 A CN 200810129660A CN 101623306 B CN101623306 B CN 101623306B
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- Prior art keywords
- herba pteridis
- pteridis multifidae
- ethanol
- pill
- extract
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a bracken pill and a preparation method thereof. The method comprises the following steps: dissolving bracken extract in a proper solvent; adding the solution into a fused substrate through a dispersive dripping method; evenly stirring the mixture; dripping the mixture; and condensing the mixture into pills.
Description
Technical field
The invention belongs to medical technical field, be specifically related to bracken pill and manufacture method thereof.
Background technology
Herba Pteridis Multifidae extract is the Chinese herbal and crude drugs preparations that extracts from China Chinese herbal medicine Pteridaceae Pteris plant Herba Pteridis Multifidae (Pteris multifida Poir.), the medicinal ingredient such as total flavonoid, sterol, aminoacid, lactone, phenolic substance that wherein mainly contains Herba Pteridis Multifidae, Herba Pteridis Multifidae has heat-clearing and toxic substances removing, dampness removing is treating stranguria, removing heat from blood, antibacterial, antiinflammation, be usually used in bacillary dysentery, enteritis, acute, chronic pyelonephritis, cystitis, urinary tract infection have the bibliographical information total flavone of phoenix-tail fern to have the treatment heart, cerebrovascular effect in the recent period.Compare with similar drugs, it is strong, rapid-action that bracken pill has an antibacterial action, can make things convenient for the advantages such as oral application.Since in the Herba Pteridis Multifidae composition such as total flavone part have draw moist, principal agent dosage is little, volume with the sheet of traditional method preparation and capsule is large, time disintegration is relatively long, dissolution and dissolution rate are low, supplementary product consumption is large, and old people and bed patient and dysphagia patien take inconvenience, and compliance is poor.
Have in the market similar oral formulations product or not, and do not have the Herba Pteridis Multifidae extract preparation, particularly drop pill of pure Chinese herbal medicine, this efficient, quick-acting, Chinese medicine preparation that bioavailability is high.The exploitation bracken pill has practical value concerning current medical market field, also embodied novelty of the present invention and practicality.
The present invention makes bracken pill by using fusion method and solid dispersion technology, correct and overcome some defectives of tablet, capsule, because the drop pill volume is little, can oral or buccal, provide great convenience to elderly patients and dysphagia patien, improved the compliance of medication.
Summary of the invention
The present invention makes bracken pill by using fusion method and solid dispersion technology, and it is rapid to have a disintegrate, and dissolution and dissolution rate improve, the steady quality characteristics.Because the drop pill volume is little, easy to carry and use, can oral or buccal, the old people is bed patient and dysphagia patien's taking convenience especially, compliance is good, and bioavailability is high, relatively and tablet, capsule, the drop pill supplementary product consumption is few, working condition and production equipment are simple, reduce and pollute, and reduce labor intensity, reduce production costs, show characteristics of the present invention.
By Herba Pteridis Multifidae extract is prepared into drop pill, be applied to treat the aspect diseases such as bacillary dysentery, enteritis, nephritis, urinary tract infection and the heart, cerebrovascular, also be characteristics of the present invention.
The existing pharmaceutic adjuvant that meets medicinal requirements of adjuvant that the present invention is selected also has the natural edible-plant adjuvant.Sum up by lot of experiments, obtain a result, this drug component forms and comprises: Herba Pteridis Multifidae extract, appropriate amount of auxiliary materials, wherein adjuvant comprises the fillibility adjuvant and has the plasticity adjuvant, the fillibility adjuvant has Macrogol 4000,6000,1500, polyoxyethylene stearate (40) ester, polyoxyethylene sorbitan monoleate, xylitol, sorbitol, mannitol, lactose, sucrose, insect wax, sodium stearate etc., the plasticity adjuvant has glycerin gelatine, Resina persicae, arabic gum, starch, dextrin, alginic acid, glucosamine etc.
Preferred substrate adjuvant of the present invention is Macrogol 4000 and polyethylene glycol 6000, and Macrogol 4000 is 1 with the ratio of the weight of poly-second 2 6000: 0.3-0.5.Xylitol is 1 with the ratio of the weight of starch: 0.3-1: 0.5, or the ratio of sorbitol and the weight of starch is 1: 0.2-1: 0.5.
Herba Pteridis Multifidae extract is 1 with the ratio of the weight of adjuvant in the pharmaceutical composition of the present invention: 0.5-1: 20.
Preferred pharmaceutical composition Chinese medicine of the present invention is 1 with the ratio of adjuvant: 4-1: 12.
Best pharmaceutical composition Chinese medicine of the present invention is 1 with the ratio of adjuvant: 2-1: 10.
The ratio of the adjuvant of pharmaceutical composition of the present invention and the consumption of medicine all is in pharmaceutics and the pharmacopeia allowed band, Herba Pteridis Multifidae extract is measured main component total flavone of phoenix-tail fern content, feed intake by metering, make the Herba Pteridis Multifidae content of every ball reach the requirement of pharmacopeia regulation same amount, the prepared drop pill of the present invention have easy, the steady quality of preparation, efficient, quick-acting, clinical administration convenient, can oral or buccal.
The present invention is based on fusion method and solid dispersion technology, just 1 weight portion Herba Pteridis Multifidae extract and 2 to 10 parts by weight solvent are through being dissolved into homogeneous solution, join in the substrate of 2 to 20 weight portion meltings by the phase process for dispersing that disperses to drip, stir, press drop pill dropping preparation method dripping in coolant, be condensed into ball, wipe coolant, drying, and get final product.
Specific implementation method
One, example 1
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol of Herba Pteridis Multifidae extract, add in the substrate that the polyethylene glycol 6000, Macrogol 4000, polyoxyethylene sorbitan monoleate of melting form, be stirred well to evenly, take dimethicone or white oil as coolant, 15 ℃ of following drippings become ball, wipe ball, drying, and get final product.
Two, example 2
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol of Herba Pteridis Multifidae extract, add in the substrate that the Macrogol 4000, polyoxyethylene sorbitan monoleate of melting form, be stirred well to evenly, take dimethicone or white oil as coolant, 10 ℃ of following drippings become ball, wipe ball, drying, and get final product.
Three, example 3,
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol of Herba Pteridis Multifidae extract, add in the substrate that the polyethylene glycol 6000, polyoxyethylene sorbitan monoleate of melting form, be stirred well to evenly, take dimethicone or white oil as coolant, 15 ℃ of following drippings become ball, wipe ball, drying, and get final product.
Four, example 4
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol of Herba Pteridis Multifidae extract, the Macrogol 4000 that adds melting, polyoxyethylene stearate 40) in the substrate that forms of ester, be stirred well to evenly, take or white oil or dimethicone as coolant, 15 ℃ of following drippings become ball, the wiping ball is dry, and get final product.
Five, example 5,
Prescription
Method for making: Herba Pteridis Multifidae extract is dissolved in the ethanol fully dissolving, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, add in the substrate that insect wax, sodium stearate, the polyoxyethylene sorbitan monoleate of melting form, be stirred well to evenly, become ball with 5 ℃ of following drippings of brine ice, wipe ball, drying, and get final product.
Six, example 6
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, gelatin, glycerol adds the water mixing, heating in water bath stirred evenly into solution in 1 hour, was chilled to 50 ℃ and was added dropwise to Herba Pteridis Multifidae dispersion ethanol, stirred, insulation to 65 ℃ is cooled off in medicinal plant oil with the dosing pump dropping-pill machine, dry, press the soft capsule conventional drying, and get final product.
Seven, example 7
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, xylitol adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise at last Herba Pteridis Multifidae and disperse ethanol, stir, insulation is dripped in white oil or edible oil with dosing pump pill dripping machine or water dropper to 65 ℃ and is cooled off, and dries, drying, and get final product.
Eight, example 8
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, sorbitol adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise at last Herba Pteridis Multifidae and disperse ethanol, stir, insulation is dripped cooling below 15 ℃ in white oil or edible oil to 65 ℃ with dosing pump pill dripping machine or water dropper, dries, drying, and get final product.
Nine, example 9
Prescription
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, lactose adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise at last Herba Pteridis Multifidae and disperse ethanol, stir, insulation to 65 ℃ is dripped cooling below 15 ℃ in white oil or edible oil with dosing pump pill dripping machine or water dropper, dries drying, and get final product.
Ten, example 10
Prescription:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, xylitol adds an amount of mixing of water, heats to stir evenly into solution in 5 minutes, is chilled to 60 ℃, add arabic gum, polyoxyethylene sorbitan monoleate, heating in water bath 65-80 ℃, to dissolving, stir, be added dropwise at last Herba Pteridis Multifidae and disperse ethanol, stir, insulation to 65 ℃ is dripped cooling below 15 ℃ in white oil or edible oil with dosing pump pill dripping machine or water dropper, dry, drying, and get final product.
Claims (1)
1. a bracken pill is characterized in that, is processed into by following composition:
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol of Herba Pteridis Multifidae extract, for subsequent use, sorbitol adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise at last Herba Pteridis Multifidae and disperse ethanol, stir, insulation is dripped cooling below 15 ℃ in white oil or edible oil to 65 ℃ with dosing pump pill dripping machine or water dropper, dries, drying, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101296604A CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810137879.9 | 2008-07-07 | ||
| CN200810137879 | 2008-07-07 | ||
| CN2008101296604A CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101623306A CN101623306A (en) | 2010-01-13 |
| CN101623306B true CN101623306B (en) | 2013-03-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101296604A Expired - Fee Related CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
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|---|---|
| CN (1) | CN101623306B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697930A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Phoenix-tail fern traditional Chinese medicine decoction for treating dysentery and preparation method for decoction |
-
2008
- 2008-08-05 CN CN2008101296604A patent/CN101623306B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 欧莉.中药凤尾草的研究进展.《中医药导报》.2008,第14卷(第3期),92-93. * |
| 范碧亭.滴丸.《中药药剂学》.上海科学技术出版社,1997,380-381. * |
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| Publication number | Publication date |
|---|---|
| CN101623306A (en) | 2010-01-13 |
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