CN101623306A - Bracken pill and preparation method thereof - Google Patents
Bracken pill and preparation method thereof Download PDFInfo
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- CN101623306A CN101623306A CN200810129660A CN200810129660A CN101623306A CN 101623306 A CN101623306 A CN 101623306A CN 200810129660 A CN200810129660 A CN 200810129660A CN 200810129660 A CN200810129660 A CN 200810129660A CN 101623306 A CN101623306 A CN 101623306A
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- herba pteridis
- pteridis multifidae
- pill
- bracken
- coolant
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a bracken pill and a preparation method thereof. The method comprises the following steps: dissolving bracken extract in a proper solvent; adding the solution into a fused substrate through a dispersive dripping method; evenly stirring the mixture; dripping the mixture; and condensing the mixture into pills.
Description
Technical field
The invention belongs to medical technical field, be specifically related to bracken pill and manufacture method thereof.
Background technology
Herba Pteridis Multifidae extract is the Chinese herbal and crude drugs preparations that extracts from China Chinese herbal medicine Pteridaceae Pteris plant Herba Pteridis Multifidae (Pteris multifidaPoir.), the medicinal ingredient such as total flavonoid, sterol, aminoacid, lactone, phenolic substance that wherein mainly contains Herba Pteridis Multifidae, Herba Pteridis Multifidae has heat-clearing and toxic substances removing, dampness removing is treating stranguria, removing heat from blood, antibacterial, antiinflammation, be usually used in bacillary dysentery, enteritis, acute, chronic pyelonephritis, cystitis, urinary tract infection have the bibliographical information total flavone of phoenix-tail fern to have the treatment heart, cerebrovascular effect in the recent period.Compare with similar medicine, it is strong, rapid-action that bracken pill has an antibacterial action, can make things convenient for advantages such as oral application.Since in the Herba Pteridis Multifidae composition such as total flavone part have draw moist, principal agent dosage is little, sheet and capsular volume with the traditional method preparation are big, time disintegration is long relatively, dissolution and dissolution rate are low, supplementary product consumption is big, and old people and bed patient and dysphagia patien take inconvenience, and compliance is poor.
Have similar oral formulations product in the market or not, and do not have the Herba Pteridis Multifidae extract preparation, particularly drop pill of pure Chinese herbal medicine, this efficient, quick-acting, Chinese medicine preparation that bioavailability is high.The exploitation bracken pill has practical value concerning current medical market field, also embodied novelty of the present invention and practicality.
The present invention makes bracken pill by using fusion method and solid-state dispersion technology, correct and overcome some defectives of tablet, capsule, because the drop pill volume is little, can oral or buccal, provide great convenience to elderly patients and dysphagia patien, improved the compliance of medication.
Summary of the invention
The present invention makes bracken pill by using fusion method and solid-state dispersion technology, and it is rapid to have a disintegrate, and dissolution and dissolution rate improve, the steady quality characteristics.Because the drop pill volume is little, easy to carry and use, can oral or buccal, the old people is bed patient and dysphagia patien's taking convenience especially, compliance is good, the bioavailability height, relatively and tablet, capsule, the drop pill supplementary product consumption is few, working condition and production equipment are simple, reduce and pollute, and reduce labor intensity, reduce production costs, show characteristics of the present invention.
By Herba Pteridis Multifidae extract is prepared into drop pill, be applied to treat aspect diseases such as bacillary dysentery, enteritis, nephritis, urinary tract infection and the heart, cerebrovascular, also be characteristics of the present invention.
The existing pharmaceutic adjuvant that meets medicinal requirements of adjuvant that the present invention is selected also has the natural edible-plant adjuvant.By a large amount of Test Summaries, obtain a result, this drug component is formed and is comprised: Herba Pteridis Multifidae extract, appropriate amount of auxiliary materials, wherein adjuvant comprises the fillibility adjuvant and has the plasticity adjuvant, the fillibility adjuvant has Macrogol 4000,6000,1500, polyoxyethylene stearate (40) ester, polyoxyethylene sorbitan monoleate, xylitol, sorbitol, mannitol, lactose, sucrose, insect wax, sodium stearate etc., the plasticity adjuvant has glycerin gelatine, Resina persicae, arabic gum, starch, dextrin, alginic acid, glucosamine etc.
Preferred substrate adjuvant of the present invention is Macrogol 4000 and polyethylene glycol 6000, and Macrogol 4000 is 1 with the ratio of the weight of poly-second 2 6000: 0.3-0.5.Xylitol is 1 with the ratio of the weight of starch: 0.3-1: 0.5, or the ratio of sorbitol and the weight of starch is 1: 0.2-1: 0.5.
Herba Pteridis Multifidae extract is 1 with the ratio of the weight of adjuvant in the pharmaceutical composition of the present invention: 0.5-1: 20.
Preferred pharmaceutical composition Chinese medicine of the present invention is 1 with the ratio of adjuvant: 4-1: 12.
Best pharmaceutical composition Chinese medicine of the present invention is 1 with the ratio of adjuvant: 2-1: 10.
The ratio of the adjuvant of pharmaceutical composition of the present invention and amount of drug all is in pharmaceutics and the pharmacopeia allowed band, Herba Pteridis Multifidae extract is measured main component total flavone of phoenix-tail fern content, feed intake by metering, make the Herba Pteridis Multifidae content of every ball reach the requirement of pharmacopeia regulation same amount, the prepared drop pill of the present invention have easy, the steady quality of preparation, efficient, quick-acting, clinical administration convenient, can oral or buccal.
The present invention is based on fusion method and solid-state dispersion technology, just 1 weight portion Herba Pteridis Multifidae extract and 2 to 10 parts by weight solvent are through being dissolved into homogeneous solution, join in 2 to the 20 weight portion molten matrix by the phase process for dispersing that disperses to drip, stir, press the drop pill dropping preparation method and in coolant, drip system, be condensed into ball, wipe coolant, drying, promptly.
Specific implementation method
One, example 1
Prescription:
Herba Pteridis Multifidae extract 20g
Polyethylene glycol 6000 20g
Macrogol 4000 20g
Polyoxyethylene sorbitan monoleate 0.6g
Ethanol 5ml
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol liquid of Herba Pteridis Multifidae extract, add in the substrate of fused polyethylene glycol 6000, Macrogol 4000, polyoxyethylene sorbitan monoleate composition, be stirred well to evenly, with dimethicone or white oil is coolant, drips below 15 ℃ and makes ball, wipes ball, drying, promptly.
Two, example 2
Prescription:
Herba Pteridis Multifidae extract 20g
Macrogol 4000 40g
Polyoxyethylene sorbitan monoleate 0.6g
Ethanol 5ml
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol liquid of Herba Pteridis Multifidae extract, add in the substrate of fused Macrogol 4000, polyoxyethylene sorbitan monoleate composition, be stirred well to evenly, with dimethicone or white oil is coolant, drips below 10 ℃ and makes ball, wipes ball, drying, promptly.
Three, example 3,
Prescription:
Herba Pteridis Multifidae extract 20g
Polyethylene glycol 6000 40g
Polyoxyethylene sorbitan monoleate 0.6g
Ethanol 5ml
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol liquid of Herba Pteridis Multifidae extract, add in the substrate of fused polyethylene glycol 6000, polyoxyethylene sorbitan monoleate composition, be stirred well to evenly, with dimethicone or white oil is coolant, drips below 15 ℃ and makes ball, wipes ball, drying, promptly.
Four, example 4
Prescription:
Herba Pteridis Multifidae extract 20g
Macrogol 4000 30g
Polyoxyethylene stearate { 40} ester 10g
Ethanol 5ml
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol liquid of Herba Pteridis Multifidae extract, add fused Macrogol 4000, polyoxyethylene stearate is { in the substrate that the 40} ester is formed, be stirred well to evenly, with or white oil or dimethicone be coolant, drip below 15 ℃ and make ball, wiping ball drying, promptly.
Five, example 5,
Prescription
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Insect wax 20g
Sodium stearate 20g
Polyoxyethylene sorbitan monoleate 0.6g
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol liquid of Herba Pteridis Multifidae extract, add in the substrate of fused insect wax, sodium stearate, polyoxyethylene sorbitan monoleate composition, be stirred well to evenly, drip below 5 ℃ with brine ice and make ball, wipe ball, drying, promptly.
Six, example 6
Prescription:
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Gelatin 30g
Glycerol 10g
Polyoxyethylene sorbitan monoleate 0.6g
Medicinal plant oil is an amount of
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, become the dispersion ethanol liquid of Herba Pteridis Multifidae extract, standby, gelatin, glycerol adds the water mixing, heating in water bath stirred evenly into solution in 1 hour, was chilled to 50 ℃ and was added dropwise to Herba Pteridis Multifidae dispersion ethanol liquid, stirred, insulation to 65 ℃ is cooled off in medicinal plant oil with the dosing pump dropping-pill machine, dry, press the soft capsule conventional drying, promptly.
Seven, example 7
Prescription:
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Xylitol 25g
Starch 5g
Polyoxyethylene sorbitan monoleate 0.6g
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol liquid of Herba Pteridis Multifidae extract, standby, xylitol adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise to Herba Pteridis Multifidae at last and disperse ethanol liquid, stir, insulation is dripped in white oil or edible oil with dosing pump drop pill machine or water dropper to 65 ℃ and is cooled off, and dries, drying, promptly.
Eight, example 8
Prescription:
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Sorbitol 30g
Starch 10g
Polyoxyethylene sorbitan monoleate 0.6g
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol liquid of Herba Pteridis Multifidae extract, standby, sorbitol adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise to Herba Pteridis Multifidae at last and disperse ethanol liquid, stir, insulation is dripped cooling below 15 ℃ in white oil or edible oil to 65 ℃ with dosing pump drop pill machine or water dropper, dries, drying, promptly.
Nine, example 9
Prescription
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Lactose 30g
Starch 10g
Polyoxyethylene sorbitan monoleate 0.6g
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol liquid of Herba Pteridis Multifidae extract, standby, lactose adds an amount of mixing of water, and heating in water bath 5 minutes stirs evenly into solution, be chilled to 60 ℃, add starch, polyoxyethylene sorbitan monoleate, stir, be added dropwise to Herba Pteridis Multifidae at last and disperse ethanol liquid, stir, insulation to 65 ℃ is dripped cooling below 15 ℃ in white oil or edible oil with dosing pump drop pill machine or water dropper, dries drying, promptly.
Ten, example 10
Prescription:
Herba Pteridis Multifidae extract 20g
Ethanol 5ml
Xylitol 30g
Arabic gum 10g
Polyoxyethylene sorbitan monoleate 0.6g
Make 1000 balls
Method for making: Herba Pteridis Multifidae extract is dissolved in fully dissolving in the ethanol, becomes the dispersion ethanol liquid of Herba Pteridis Multifidae extract, standby, xylitol adds an amount of mixing of water, heats to stir evenly into solution in 5 minutes, is chilled to 60 ℃, add arabic gum, polyoxyethylene sorbitan monoleate, heating in water bath 65-80 ℃, to dissolving, stir, be added dropwise to Herba Pteridis Multifidae at last and disperse ethanol liquid, stir, insulation to 65 ℃ is dripped cooling below 15 ℃ in white oil or edible oil with dosing pump drop pill machine or water dropper, dry, drying, promptly.
Claims (10)
1. bracken pill and preparation method thereof: its feature this in 1 weight portion Herba Pteridis Multifidae extract and 1 to 10 parts by weight solvent through being dissolved into solution, add in 2 to the 15 weight portion molten matrix by disperseing to drip dispersive method, stir, press the drop pill dropping preparation method and in coolant, drip system, be condensed into ball, wipe coolant, drying, promptly.
2. the main medicinal ingredient of Herba Pteridis Multifidae extract according to claim 1 is a flavone compound, and Herba Pteridis Multifidae through clinical use proof to treatments such as bacillary dysentery, enteritis, urinary tract infection effectively.Also effective to the treatment cardiovascular and cerebrovascular disease.
3. bracken pill according to claim 1, its feature includes but not limited to ethanol, glycerol, propylene glycol etc. at the described solvent of claim 1.
4. substrate according to claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, insect wax, sodium stearate, polyoxyethylene stearate (40) ester, polyoxyethylene sorbitan monoleate, xylitol, mannitol, lactose, sucrose, starch, dextrin, medicinal plant oil, glycerin gelatine, Resina persicae, arabic gum, alginic acid, glucosamine.
5. coolant according to claim 1 includes but not limited to dimethicone, liquid paraffin, edible vegetable oil, ethanol, brine ice etc.
6. bracken pill according to claim 2 is characterized in that the adjuvant and the ratio of the weight of Herba Pteridis Multifidae extract are 1: 1-20: 1.
7. bracken pill according to claim 2, it is characterized in that solvent and Herba Pteridis Multifidae extract weight ratio be 0.5: 1-5: 1.
8. according to the described bracken pill of claim 1-7, it is characterized in that preparation method may further comprise the steps:
(1) accurately take by weighing Herba Pteridis Multifidae extract, various adjuvant is standby.
(2) solvent is added Herba Pteridis Multifidae extract, stirring and dissolving are evenly, and be standby.
(3) various adjuvants are placed 65-90 ℃ of heating and melting, stir, mixing time is 10-120 minute, insulation.
(4) Herba Pteridis Multifidae extract solution is added in the mixture fused solution of adjuvant composition, disperse, stir, following system of 50-95 ℃ of temperature, water dropper diameter 1 ~ 5mm, splash into-5-20 ℃ coolant in, treat that ball solidifies after, with the most coolant of ball drop, wipe coolant and dry to the greatest extent, promptly.
9. described according to Claim 8 bracken pill preparation method, it is characterized in that adjuvant mixture heated melt temperature is that 60-85 ℃ of mixing time is 20-60 minute, the water dropper bore be 1.5-3.5mm to drip the system temperature be 70-85 ℃, condensing agent is-dimethicone of 3-15 ℃ or liquid paraffin, edible vegetable oil.
10. the preparation method of bracken pill as claimed in claim 8 is characterized in that adjuvant mixture heated melt temperature is 80 ℃, and dripping the system temperature is 80 ℃, the water dropper bore is 2.5 millimeters, and coolant is a methyl-silicone oil, and epimere is 10 ℃, stage casing 4-6 ℃, latter end is 0-2 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101296604A CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810137879 | 2008-07-07 | ||
| CN200810137879.9 | 2008-07-07 | ||
| CN2008101296604A CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101623306A true CN101623306A (en) | 2010-01-13 |
| CN101623306B CN101623306B (en) | 2013-03-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101296604A Expired - Fee Related CN101623306B (en) | 2008-07-07 | 2008-08-05 | Bracken pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101623306B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697930A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Phoenix-tail fern traditional Chinese medicine decoction for treating dysentery and preparation method for decoction |
-
2008
- 2008-08-05 CN CN2008101296604A patent/CN101623306B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697930A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Phoenix-tail fern traditional Chinese medicine decoction for treating dysentery and preparation method for decoction |
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| Publication number | Publication date |
|---|---|
| CN101623306B (en) | 2013-03-20 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130320 Termination date: 20150805 |
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| EXPY | Termination of patent right or utility model |