CN101269108A - Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof - Google Patents
Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof Download PDFInfo
- Publication number
- CN101269108A CN101269108A CNA200810111777XA CN200810111777A CN101269108A CN 101269108 A CN101269108 A CN 101269108A CN A200810111777X A CNA200810111777X A CN A200810111777XA CN 200810111777 A CN200810111777 A CN 200810111777A CN 101269108 A CN101269108 A CN 101269108A
- Authority
- CN
- China
- Prior art keywords
- framework material
- sustained
- radix tripterygii
- extract
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a drug compound which has the efficacies of dispelling wind, removing dampness, stimulating the circulation of blood, relaxing muscles and joints, subsiding swellings and relieving pain, and is used for treating rheumatic diseases. The drug compound aims to supplement the deficiencies of the prior oral pharmaceutical preparation used for treating the symptoms of rheumatoid arthritis (The symptoms are that joints are swollen, painful and hard to straighten, the limbs are chill tender and cold weather worsens the situation, and waist and legs lack strength or chill and fever jumble.) and provide a combined oral pharmaceutical preparation, thunder god vine total terpene slow-release dropping pill which has the advantages that the bioavailability is high, the effect is rapid, the release time is long, the taking frequency is low, toxic and side effects are small, the medicine content is high, the dose is small, the dose is precise, the medicine-taking is convenient, the price is low and the portability is available. The dropping pill is prepared according to a definite ingredient constitution by adopting the thunder god vine extractive as the ingredient and by adopting a hydrophilic framework material and a hydrophobic framework material as the stroma.
Description
Technical field
The invention belongs to the pharmaceutical technology field, relate to a kind of expelling wind and removing dampness that has, the Shujin Lip river of living, the reducing swelling and alleviating pain effect is used for the treatment of the cold-damp invasion and attack, the arthralgia that obstruction of collaterals by blood stasis causes, joint stuffiness, aversion to cold and cold limbs is met cold increasing the weight of, weakness of the waist and knees, or disease such as cold and heat are staggered; Rheumatoid arthritis is seen the pharmaceutical composition that above-mentioned symptom person is arranged, and is raw material with the Radix Tripterygii Wilfordii extract particularly, a kind of tripterygium wilfordii total terpene sustained-release dropping pill preparation that is prepared from.
Background technology
The tripterygium total terpenoids sheet that is prepared from according to the prescription that provides among the national drug standards WS-10715 (ZD-0715)-2002 and preparation method, it is a kind of expelling wind and removing dampness that has, Shujin Lip river alive has the reducing swelling and alleviating pain effect, is used for the treatment of the cold-damp invasion and attack, the arthralgia that obstruction of collaterals by blood stasis causes, joint stuffiness, aversion to cold and cold limbs is met cold increasing the weight of, weakness of the waist and knees, or disease such as cold and heat are staggered; Rheumatoid arthritis sees above-mentioned symptom person's oral Chinese medicine preparation, through clinical verification, steady quality, determined curative effect is clinical and family is used for the treatment of the common drug preparation of above disease.
Below be the contained partial content of this drug standard:
Prescription: Radix Tripterygii Wilfordii extract (in Radix Tripterygii Wilfordii lactone alcohol) 20mg, starch 75g, dextrin 75g, sucrose 4g, micropowder silica gel 0.75g;
Method for making: get Radix Tripterygii Wilfordii extract, behind dextrin, starch, the abundant mixing of micropowder silica gel, add 40% syrup, make granule, drying, tabletting, the bag film-coat, promptly.
Be explained as follows for this product in the appended description:
Nomenclature of drug: tripterygium total terpenoids sheet;
Main component: Radix Tripterygii Wilfordii extract;
Character: this product is a Film coated tablets, removes film-coat and shows brown;
Function cures mainly: expelling wind and removing dampness, Shujin Lip river alive, reducing swelling and alleviating pain.Be used for cold-damp invasion and attack, the arthralgia that obstruction of collaterals by blood stasis causes, joint stuffiness, aversion to cold and cold limbs is met cold increasing the weight of, weakness of the waist and knees, or disease such as cold and heat are staggered; Rheumatoid arthritis is seen above-mentioned symptom person;
Usage and dosage: oral, one time 2,3 times on the one.
For patient with above-mentioned disease, need more that a kind of to have the time of proving effective long, the medicine rapidly that proves effective is owing to reasons such as technologies of preparing, and the oral formulations of present most drug, especially the oral formulations of Chinese medicine exists all after taking that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, blood drug level is unstable, and release is insufficient, patient's medicining times is many, problems such as liver sausage first pass effect and bioavailability are lower, thus the performance of drug effect influenced, also directly affect therapeutic effect.
In addition, conventional peroral dosage form as tablet, capsule etc., because the technology of granulation is arranged, therefore can produce bigger dust pollution in preparation process, can staff's health be worked the mischief to a certain extent, also can cause certain pollution to environment simultaneously.Moreover, the complex manufacturing of conventional oral formulations, production cost is higher, thereby patient's drug cost is also improved thereupon, is unfavorable for improving the ability of seeking medical advice of extensive patients, also is unfavorable for improving the general health level of society.
Summary of the invention
Purpose of the present invention is to replenish the existing cold-damp invasion and attack that are used for the treatment of, the arthralgia that obstruction of collaterals by blood stasis causes, and joint stuffiness, aversion to cold and cold limbs is met cold increasing the weight of, weakness of the waist and knees, or disease such as cold and heat are staggered; The deficiency of rheumatoid arthritis sees above-mentioned symptom person's oral drug preparation, a kind of bioavailability height that has is provided, quick produce effects, drug release time is long, medicining times is few, toxic and side effects is littler, and the medicament contg height, and taking dose is little, taking dose is accurate, taking convenience, cheap, and be convenient to the drug composition oral preparation tripterygium wilfordii total terpene sustained-release dropping pill of going out to carry.
Tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention determines that through a large amount of experiment sievings based on the preparation technology of Chinese traditional patent formulation tripterygium total terpenoids sheet, process is adjusted part technology, and cooperates drop pill preparation technology to be prepared from.Be prepared by the following technical solutions, can obtain tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention:
[preparation method]
1. raw material: Radix Tripterygii Wilfordii extract;
2. substrate---hydrophilic framework material and hydrophobicity framework material are formed;
2.1 hydrophilic framework material: the mixture of one or more in polyethylene glycol 1500, Macrogol 4000, polyethylene glycol 6000, polyvinylpyrrolidone, the above-mentioned pharmaceutically suitable carrier of microcrystalline Cellulose;
2.2 hydrophobicity framework material: the mixture of one or more in stearic acid, cohune eleostearic acid, glyceryl monostearate and the above-mentioned pharmaceutically suitable carrier of octadecanol;
3. component constitutes: calculate according to percentage by weight, tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention is by the substrate of 20-40% Radix Tripterygii Wilfordii extract and 60-80%, and substrate comprises 40-60% hydrophilic framework material and 20-30% hydrophobicity framework material.
4. preparation method: constitute according to said components, accurately take by weighing Radix Tripterygii Wilfordii extract and hydrophilic framework material and hydrophobicity framework material, in advance hydrophilic framework material and hydrophobicity framework material are placed that heating while stirring makes fusion in the heating container, gradation adds Radix Tripterygii Wilfordii extract when stirring then, and is standby until the fused solution that obtains containing Radix Tripterygii Wilfordii extract and substrate and/or emulsion and/or suspension;
5. adopt homemade or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on 50 ℃～80 ℃, the temperature cooling of condensed fluid, and to keep the condensed fluid upper temp be 50 ℃～20 ℃, and bottom temp is 10 ℃～0 ℃ a state;
6. the temperature for the treatment of dropping-pill machine head and condensation column inner condensat liquid is stable respectively when reaching above-mentioned state, to contain the fused solution of Radix Tripterygii Wilfordii extract and substrate and/or emulsion and/or suspension places in the water dropper jar of drop pill machine, splash into and shrink shaping in the condensed fluid, promptly.
Annotate: condensed fluid can be any one or the two or more mixture in liquid paraffin, dimethicone, the vegetable oil.
[attached: a kind of preparation method of Radix Tripterygii Wilfordii extract]
Get the Radix Tripterygii Wilfordii root and rhizome, be cut into the thick decoction pieces of 3～5mm, with 85% ethanol (5,4,4 times of amounts) reflux, extract, 3 times, each 4 hours, the extracting solution decompression recycling ethanol is to thick paste shape (relative density 1.25～1.30,60 ℃), dry below 60 ℃, dry extract is pulverized, and takes off ester, removal of solvent under reduced pressure with No. 90 petroleum ether, dry below 60 ℃, promptly.
Given here is according to the preparation method of a kind of Chinese medicine dry powder comparatively commonly used, its processing step adjustment is formed again.Similarly method is a lot, is not limited to this a kind of method during actual enforcement.
Beneficial effect
The tripterygium total terpenoids sheet that is prepared from according to the prescription that provides among the national drug standards WS-10715 (ZD-0715)-2002 and preparation method, it is a kind of expelling wind and removing dampness that has, Shujin Lip river alive, the reducing swelling and alleviating pain effect is used for the treatment of the cold-damp invasion and attack, the arthralgia that obstruction of collaterals by blood stasis causes, joint stuffiness, aversion to cold and cold limbs is met cold increasing the weight of, weakness of the waist and knees, or disease such as cold and heat are staggered; Rheumatoid arthritis sees above-mentioned symptom person's oral Chinese medicine preparation, through clinical verification, steady quality, determined curative effect is clinical and family is used for the treatment of the common drug preparation of above disease.
Owing to reasons such as technologies of preparing, the oral formulations of most drug, especially the oral formulations of Chinese medicine, exist all after taking that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, blood drug level is unstable, problems such as release is insufficient, and patient's medicining times is many, and liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect.
In addition, conventional peroral dosage form as tablet, capsule etc., because the technology of granulation is arranged, therefore can produce bigger dust pollution in preparation process, can staff's health be worked the mischief to a certain extent, also can cause certain pollution to environment simultaneously.Moreover, the complex manufacturing of conventional oral formulations, production cost is higher, thereby patient's drug cost is also improved thereupon, is unfavorable for improving the ability of seeking medical advice of extensive patients, also is unfavorable for improving the general health level of society.
Tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention is compared with the tripterygium total terpenoids sheet has following beneficial effect:
1. tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention; utilize hydrophilic framework material and hydrophobicity framework material as substrate; make solid dispersion with the dry powder that contains the Radix Tripterygii Wilfordii extract active component; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases; and substrate has the hydrophilic framework material; medicine had wetting action; can make medicine molten microgranule or the solution of loosing into rapidly; thereby make the dissolving of medicine and absorb quickening; thereby improved bioavailability, brought into play effects such as efficient, quick-acting.Because of substrate has the hydrophobicity framework material, make medicine have slow release release effect again, reach long-acting function.
Compare with the administering mode of tripterygium total terpenoids sheet, exist essential distinction.Utilize the sustained-release dropping pill of solid dispersion technology preparation, can adopt oral and sublingual administration, effective ingredient is fully contacted with mucomembranous surface, absorb, directly enter blood circulation by mucomembranous epithelial cell.Because active constituents of medicine directly enters blood circulation without gastrointestinal tract and liver, avoided first pass effect effectively, also avoided gastrointestinal irritation, thereby thereby it is rapid to make that tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention has an onset, the bioavailability height, characteristics such as side effect is little, and medication is convenient.
2. tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention contacts promptly with saliva and to dissolve rapidly, and is absorbed by oral mucosa, and is not only rapid-action, and the influence of not taken food, and promptly all can containing take after meal ante cibum.
3. tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention mixes the dry powder that contains active constituents of medicine mutually with molten matrix, splashes in the not miscible condensed fluid and makes.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
In sum, make tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention have the advantage of triple effect (quick-acting, efficient, long-acting), three little (taking dose is little, toxicity is little, side effect little), five convenience (convenient for production, store convenience, convenient transportation, easy to carry, easy to use).
The specific embodiment
Now with several groups of specific embodiments, be described further with regard to the preparation method of tripterygium wilfordii total terpene sustained-release dropping pill of the present invention.
First group:
In gross weight 100g, take by weighing substrate PEG6000 20%, PEG1500 40%, stearic acid 10%, octadecanol 10%, raw material Radix Tripterygii Wilfordii extract 20%; By above-mentioned preparation method preparation.
Products obtained therefrom, 2 hours cumulative release percentage rate are that 39～52%, 6 hours cumulative release percentage rate are that 59～83%, 10 hours cumulative release percentage rate are 80～93%, and hardness is better, and roundness is better.
Second group:
In gross weight 100g, take by weighing substrate PEG600020%, PEG400040%, stearic acid 10%, glyceryl monostearate 7%, raw material Radix Tripterygii Wilfordii extract 23%: by above-mentioned preparation method preparation.
Products obtained therefrom, 2 hours cumulative release percentage rate are that 48%～61%, 6 hours cumulative release percentage rate are that 58～79%, 10 hours cumulative release percentage rate are 79～93%, and hardness is better, and roundness is better.
The 3rd group:
In gross weight 100g, take by weighing substrate PEG4000 10%, PEG1500 40%, and PEG6000 10%, stearic acid 10%, glyceryl monostearate 5%, raw material Radix Tripterygii Wilfordii extract 25%; By above-mentioned preparation method preparation.
Products obtained therefrom, 2 hours cumulative release percentage rate are that 50%～63%, 6 hours cumulative release percentage rate are that 65～80%, 10 hours cumulative release percentage rate are 82～96%, and hardness is better, and roundness is better.
The 4th group:
In gross weight 100g, take by weighing substrate PEG4000 30%, PEG6000 15%. microcrystalline Cellulose 5%, stearic acid 15%, cohune eleostearic acid 5%, raw material Radix Tripterygii Wilfordii extract 30%; By above-mentioned preparation method preparation.
Products obtained therefrom, 2h cumulative release percentage rate is 40%～53%, and 6h cumulative release percentage rate is 56～77%, and 10h cumulative release percentage rate is 79～93%,, hardness is better, and roundness is better.
The 5th group:
In gross weight 100g, take by weighing substrate PEG4000 20%, PEG1500 15%, polyvinylpyrrolidone 5%, glyceryl monostearate 10%, octadecanol 3%, cohune eleostearic acid 7%, raw material Radix Tripterygii Wilfordii extract 40%: by above-mentioned preparation method preparation.
Products obtained therefrom, 2h cumulative release percentage rate is 38%～63%, and 6h cumulative release percentage rate is 61～84%, and 10h cumulative release percentage rate is 73～91%, and hardness is better, and roundness is better.
The 6th group:
In gross weight 100g, take by weighing substrate PEG 1,500 30%, PEG4000 10%, microcrystalline Cellulose 5%, glyceryl monostearate 13%, cohune eleostearic acid 7%, raw material Radix Tripterygii Wilfordii extract 35%: by above-mentioned preparation method preparation.
Products obtained therefrom, 2h cumulative release percentage rate is 40%～68%, and 6h cumulative release percentage rate is 73～84%, and 10h cumulative release percentage rate is 83～97%, and hardness is better, and roundness is better.
Claims (4)
1. a tripterygium wilfordii total terpene sustained-release dropping pill that is used for the treatment of rheumatism is a raw material of Chinese medicine with the Radix Tripterygii Wilfordii extract, constitute by certain component as pharmaceutically suitable carrier of substrate with hydrophilic framework material and hydrophobicity framework material to be prepared from, wherein:
1.1. substrate---hydrophilic framework material and hydrophobicity framework material are formed;
1.1.1 hydrophilic framework material: the mixture of one or more in polyethylene glycol 1500, Macrogol 4000, polyethylene glycol 6000, polyvinylpyrrolidone, the above-mentioned pharmaceutically suitable carrier of microcrystalline Cellulose;
1.1.2 hydrophobicity framework material: the mixture of one or more in stearic acid, cohune eleostearic acid, glyceryl monostearate and the above-mentioned pharmaceutically suitable carrier of octadecanol;
1.2 component constitutes: calculate according to percentage by weight, tripterygium wilfordii total terpene sustained-release dropping pill involved in the present invention is by the substrate of 20-40% Radix Tripterygii Wilfordii extract and 60-80%, and substrate comprises 40-60% hydrophilic framework material and 20-30% hydrophobicity framework material.
2. tripterygium wilfordii total terpene sustained-release dropping pill as claimed in claim 1 is characterized in that described Radix Tripterygii Wilfordii extract obtains by the following method: get the Radix Tripterygii Wilfordii root and rhizome, be cut into the thick decoction pieces of 3～5mm, use 85% ethanol, be respectively 5,4,4 times of amounts, reflux, extract, 3 times, each 4 hours, 60 ℃ of decompression recycling ethanols of extracting solution are to the thick paste shape of relative density 1.25～1.30, and dry below 60 ℃, dry extract is pulverized, and take off ester with No. 90 petroleum ether, removal of solvent under reduced pressure, dry below 60 ℃, promptly.
3. according to the preparation method of the described tripterygium wilfordii total terpene sustained-release dropping pill of claim 1, it is characterized in that constituting by following process:
3.1 constitute according to the described component of claim 1.2, accurately take by weighing Radix Tripterygii Wilfordii extract and hydrophilic framework material and hydrophobicity framework material, in advance hydrophilic framework material and hydrophobicity framework material are placed that heating while stirring makes fusion in the heating container, gradation adds Radix Tripterygii Wilfordii extract when stirring then, and is standby until the fused solution that obtains containing Radix Tripterygii Wilfordii extract and substrate and/or emulsion and/or suspension;
3.2 adopt homemade or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on 50 ℃～80 ℃, the temperature cooling of condensed fluid, and to keep the condensed fluid upper temp be 50 ℃～20 ℃, and bottom temp is 10 ℃～-4 ℃ a state;
3.3 the temperature for the treatment of dropping-pill machine head and condensation column inner condensat liquid is stable respectively when reaching above-mentioned state, to contain the fused solution of Radix Tripterygii Wilfordii extract and substrate and/or emulsion and/or suspension places in the water dropper jar of drop pill machine, splash into and shrink shaping in the condensed fluid, promptly.
4. as the preparation method of tripterygium wilfordii total terpene sustained-release dropping pill as described in the claim 3, it is characterized in that: described condensing agent be methyl-silicone oil or/and liquid paraffin or/and vegetable oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810111777XA CN101269108A (en) | 2008-05-16 | 2008-05-16 | Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810111777XA CN101269108A (en) | 2008-05-16 | 2008-05-16 | Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101269108A true CN101269108A (en) | 2008-09-24 |
Family
ID=40003499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200810111777XA Pending CN101269108A (en) | 2008-05-16 | 2008-05-16 | Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101269108A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311100A (en) * | 2015-01-20 | 2016-02-10 | 广西南宁科冠医药科技开发有限公司 | Rabdosia amethystoides slowly released drop pill with effect of eliminating stasis to subdue swelling |
| CN114831962A (en) * | 2022-04-29 | 2022-08-02 | 福建省医学科学研究院 | Triptolide solid lipid nanoparticles and preparation method of dropping pills thereof |
-
2008
- 2008-05-16 CN CNA200810111777XA patent/CN101269108A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311100A (en) * | 2015-01-20 | 2016-02-10 | 广西南宁科冠医药科技开发有限公司 | Rabdosia amethystoides slowly released drop pill with effect of eliminating stasis to subdue swelling |
| CN114831962A (en) * | 2022-04-29 | 2022-08-02 | 福建省医学科学研究院 | Triptolide solid lipid nanoparticles and preparation method of dropping pills thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100382785C (en) | Cough suppressing phlegm transforming drip pill and its preparation method | |
| CN100473394C (en) | Compound preparation of baikal skullcap root | |
| CN100382786C (en) | Bastard feverfew throat clearing drip pill and its preparation method | |
| CN101269108A (en) | Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof | |
| CN100375614C (en) | Dripping pills with jaundice eliminating liver protecting functions and its preparation method | |
| CN100348170C (en) | Yitongshu drop pill for treating pain and its preparation method | |
| CN1679676A (en) | Six-component saf-flower drops and preparation thereof | |
| CN100453072C (en) | Isatis root drops and preparation thereof | |
| CN100358562C (en) | Tendril-leaved fritillary bulb loquat drop pills and preparation method thereof | |
| CN100348169C (en) | Saussurea involucrata drop pill and its preparation method | |
| CN1322851C (en) | Tripterygium total terpenoids drop pill and its preparation method | |
| CN100358496C (en) | 'Xingnaojing' dripping pills for treating cephalitis and hepatic coma and preparation process thereof | |
| CN1322857C (en) | Xiaoke drip pill used for suppressing cough and transforming phlegm and its preparation method | |
| CN100542517C (en) | Calculus bovis detoxifying dropping pill and preparation method thereof | |
| CN100358503C (en) | Compound cynomorium drip pill and its preparation method | |
| CN100364506C (en) | Drop pills preparation in use for treating bronchitis and preparation method | |
| CN100367937C (en) | Throat dripping pill for clearing away heat and toxic material and its preparing method | |
| CN1315465C (en) | Lonicera flower mango drip pill and its preparation method | |
| CN1315470C (en) | Compound liver-benefiting dropping pill for treating hepatitis and its preparing method | |
| CN1315463C (en) | Guanxinning drip pill for treating heart disease and its preparation method | |
| CN1297255C (en) | Dripping pills for treating high blood fat and its preparing method | |
| CN100443073C (en) | Chinese Apea Ear-ring preparation capable of improving drug effect and preparation method thereof | |
| CN100348171C (en) | Yujin drop pill for clearing away the heat-evil and expelling superficial evils and its preparation method | |
| CN100358500C (en) | Fleabane and earthworm dripping pill and its preparing method | |
| CN101623306B (en) | Bracken pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080924 |