CN1726984A - Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method - Google Patents
Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method Download PDFInfo
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Abstract
A Chinese medicine in the form of dripping pill, tablet, or capsule for invigorating the function of spleen, dispelling phlegm and treating cough is prepared from 6 Chinese medicines including alum, pilose asiabell bell, Kan-sui root, etc through pulverizing alum, decocting others, filtering, concentrating, adding alcohol, laying aside, filtering, concentrating, adding said alum powder, stirring and shaping.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of the spleen strengthening and damp drying expelling phlegm for arresting cough and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or sheet or dispersible tablet or soft capsule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a granule, has listed the national drug ministry standard in.
The technology features of the Chinese medicine preparation phlegm eliminating and cough relieving granules of existing the spleen strengthening and damp drying expelling phlegm for arresting cough is to get alum powder to be broken into fine powder; The five tastes such as all the other Radix Codonopsis decoct, and decocting liquid filters; Concentrate, add ethanol, make to contain the alcohol amount and reach 50%, leave standstill, filter, concentrate; It is an amount of to add Alumen powder and Icing Sugar, makes granule, drying, promptly.
The Chinese medicine preparation phlegm eliminating and cough relieving granules agent of existing the spleen strengthening and damp drying expelling phlegm for arresting cough exists carries, uses inconvenience, shortcoming such as need boiled water to take after mixing it with water, dose is big, quality is wayward.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of the spleen strengthening and damp drying expelling phlegm for arresting cough and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of the spleen strengthening and damp drying expelling phlegm for arresting cough, it is that main component is expelling phlegm for arresting cough drop pill or sheet or the dispersible tablet or the soft capsule of Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa (vinegar system), Radix Kansui (vinegar system), Folium et Cacumen Rhododendri Mariae, Alumen.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Radix Codonopsis 20～30%, Rhizoma pinelliae cordatae 35～45%, Flos Genkwa (vinegar system), Radix Kansui (vinegar system) each 5～15%, Folium et Cacumen Rhododendri Mariae 10～15%, Alumen 1～5%;
The optimum weight percentage ratio of medicine constituent is:
Radix Codonopsis 26.7%, Rhizoma pinelliae cordatae 40%, Flos Genkwa (vinegar system), Radix Kansui (vinegar system) each 8.9%, Folium et Cacumen Rhododendri Mariae 13.3%, Alumen 2.2%.
(2) get alum powder and be broken into fine powder, sieve, fine powder is standby;
(3) getting Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa, Radix Kansui, Folium et Cacumen Rhododendri Mariae decocts with water 1～3 time, each 1～3 hour, collecting decoction left standstill 12～36 hours, filter, it is 1.10～1.30 that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45～55%, leave standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20～1.50 thick paste, standby;
(4) get the thick paste of (3) gained, add the Alumen fine powder of (2) gained, get hybrid medicine, standby;
(5) preparation method of drop pill is: with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (4) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly.
(6) preparation method of sheet (plain sheet, Film coated tablets, coated tablet, enteric coated tablet) is: get (4) gained hybrid medicine, after the adding appropriate amount of auxiliary materials, mix homogeneously is granulated, drying, and granulate, tabletting gets plain sheet; Plain sheet promptly gets Film coated tablets with film-coat material coating; Plain sheet sugar coating material coating promptly gets coated tablet; Plain sheet enteric material coating promptly gets enteric coated tablet;
Adjuvant is one or more combinations or other proper auxiliary materials of following material, uses with by arbitrary proportion: lactose, starch, carboxymethyl starch sodium, pregelatinized Starch, sucrose, glucose, mannitol, sorbitol, syrup, microcrystalline Cellulose, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl emthylcellulose, low-substituted hydroxypropyl cellulose, carboxymethylcellulose calcium, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, calcium carbonate, light magnesium oxide, Pulvis Talci, micropowder silica gel, aluminium hydroxide, boric acid, sodium chloride, dextrin, magnesium stearate, hydrogenated vegetable oil, Polyethylene Glycol, magnesium stearate, Pulvis Talci, micropowder silica gel, polyvinylpyrrolidone class material;
(7) preparation method of dispersible tablet is: get the hybrid medicine of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is pressed into dispersible tablet;
Adjuvant is one or more combinations or other proper auxiliary materials of following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, the swollen shallow lake 5000 of dimension, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid or fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
(8) the preparation of soft capsule method is: get the hybrid medicine of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is suppressed or is dripped and makes soft capsule;
One or more combinations of the following material of adjuvant or other proper auxiliary materials are used with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation of the spleen strengthening and damp drying expelling phlegm for arresting cough, it is that main component is expelling phlegm for arresting cough drop pill or sheet or the dispersible tablet or the soft capsule of Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa (vinegar system), Radix Kansui (vinegar system), Folium et Cacumen Rhododendri Mariae, Alumen.
Chinese medicine preparation energy the spleen strengthening and damp drying of the present invention, expelling phlegm for arresting cough.Be mainly used in chronic bronchitis and bronchitis and merge emphysema, the caused abundant expectoration of pulmonary heart disease, cough, disease such as pant.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption thereof are as follows:
Radix Codonopsis 1500g, Rhizoma pinelliae cordatae 2250g, Flos Genkwa (vinegar system), each 500g of Radix Kansui (vinegar system), Folium et Cacumen Rhododendri Mariae 750g, Alumen 125g;
(2) get alum powder and be broken into fine powder, sieve, standby;
(3) get Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa, Radix Kansui, Folium et Cacumen Rhododendri Mariae and decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, left standstill 24 hours, and filtered, it is 1.20 that filtrate is concentrated into relative density, put cold, add ethanol and make and contain amount of alcohol and reach 50%, leave standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.30～1.40 thick paste, standby;
(4) get the thick paste of (3) gained, add the Alumen fine powder of (2) gained, get hybrid medicine, standby;
(5) the Chinese medicine preparation drop pill of the spleen strengthening and damp drying expelling phlegm for arresting cough is the expelling phlegm for arresting cough drop pill, its preparation method is: the hybrid medicine of getting (4) gained, Polyethylene Glycol PEG6000 100g, stearic acid 20g, Poloxamer188 15g, treat that Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to the hybrid medicine that adds (4) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(6) the Chinese medicine preparation tablet of the spleen strengthening and damp drying expelling phlegm for arresting cough is expelling phlegm for arresting cough sheet (plain sheet, Film coated tablets, enteric coatel tablets), its preparation method is to get (4) gained hybrid medicine, add low-substituted hydroxypropyl cellulose 80g, pregelatinized Starch 60g, mix homogeneously, alcohol granulation with 85%, behind drying, the granulate, the magnesium stearate that adds granule total amount 3%, tabletting gets plain sheet; Plain sheet gets Film coated tablets with film-coat material coating; Plain sheet sugar coating material coating gets coated tablet; Plain sheet enteric coating material coating gets enteric coated tablet.
(7) the Chinese medicine preparation dispersible tablet of the spleen strengthening and damp drying expelling phlegm for arresting cough is the expelling phlegm for arresting cough dispersible tablet, its preparation method is to get (4) gained hybrid medicine, add the swollen shallow lake P5000 100g of dimension, polyvinylpolypyrrolidone INF-10 30g, PEG6000 20g and PEG4000 20g and cross 80 mesh sieve secondaries, mix homogeneously, direct compression, promptly.
(8) the Chinese medicine preparation soft capsule of the spleen strengthening and damp drying expelling phlegm for arresting cough is the expelling phlegm for arresting cough soft capsule, its preparation method is to get (4) gained hybrid medicine, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule.
Advantage of the present invention is:
Carry, taking convenience, do not have bad smell, the bioavilability height.
Claims (3)
1, a kind of Chinese medicine preparation of the spleen strengthening and damp drying expelling phlegm for arresting cough is characterized in that it is that main component is expelling phlegm for arresting cough drop pill or sheet or the dispersible tablet or the soft capsule of Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa (vinegar system), Radix Kansui (vinegar system), Folium et Cacumen Rhododendri Mariae, Alumen.
2, a kind of preparation method of Chinese medicine preparation of the spleen strengthening and damp drying expelling phlegm for arresting cough, it is expelling phlegm for arresting cough drop pill or sheet or dispersible tablet or preparation of soft capsule method, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Radix Codonopsis 20～30%, Rhizoma pinelliae cordatae 35～45%, Flos Genkwa (vinegar system), Radix Kansui (vinegar system) each 5～15%, Folium et Cacumen Rhododendri Mariae 10～15%, Alumen 1～5%;
(2) get alum powder and be broken into fine powder, sieve, fine powder is standby;
(3) getting Radix Codonopsis, Rhizoma pinelliae cordatae, Flos Genkwa, Radix Kansui, Folium et Cacumen Rhododendri Mariae decocts with water 1～3 time, each 1～3 hour, collecting decoction left standstill 12～36 hours, filter, it is 1.10～1.30 that filtrate is concentrated into relative density, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45～55%, leave standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20～1.50 thick paste, standby;
(4) get the thick paste of (3) gained, add the Alumen fine powder of (2) gained, get hybrid medicine, add appropriate amount of auxiliary materials, mixing is made drop pill or sheet or dispersible tablet or soft capsule;
The preparation method of its drop pill is: with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (4) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of sheet (plain sheet, Film coated tablets, coated tablet, enteric coated tablet) is: get (4) gained hybrid medicine, after the adding appropriate amount of auxiliary materials, mix homogeneously is granulated, drying, and granulate, tabletting gets plain sheet; Plain sheet promptly gets Film coated tablets with film-coat material coating; Plain sheet sugar coating material coating promptly gets coated tablet; Plain sheet enteric material coating promptly gets enteric coated tablet;
Adjuvant is one or more combinations or other proper auxiliary materials of following material, uses with by arbitrary proportion: lactose, starch, carboxymethyl starch sodium, pregelatinized Starch, sucrose, glucose, mannitol, sorbitol, syrup, microcrystalline Cellulose, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl emthylcellulose, low-substituted hydroxypropyl cellulose, carboxymethylcellulose calcium, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, calcium carbonate, light magnesium oxide, Pulvis Talci, micropowder silica gel, aluminium hydroxide, boric acid, sodium chloride, dextrin, magnesium stearate, hydrogenated vegetable oil, Polyethylene Glycol, magnesium stearate, Pulvis Talci, micropowder silica gel, polyvinylpyrrolidone class material;
The preparation method of dispersible tablet is: get the hybrid medicine of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is pressed into dispersible tablet;
Adjuvant is one or more combinations or other proper auxiliary materials of following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, the swollen shallow lake 5000 of dimension, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid or fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
The preparation method of its soft capsule is: get the hybrid medicine of (4) gained, add appropriate amount of auxiliary materials, mix homogeneously is suppressed or is dripped and makes soft capsule;
One or more combinations of the following material of adjuvant or other proper auxiliary materials are used with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
3, the preparation method of the Chinese medicine preparation of a kind of the spleen strengthening and damp drying expelling phlegm for arresting cough according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Radix Codonopsis 26.7%, Rhizoma pinelliae cordatae 40%, Flos Genkwa (vinegar system), Radix Kansui (vinegar system) each 8.9%, Folium et Cacumen Rhododendri Mariae 13.3%, Alumen 2.2%.
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| CN 200510031944 CN1726984A (en) | 2005-07-29 | 2005-07-29 | Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method |
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| CN 200510031944 CN1726984A (en) | 2005-07-29 | 2005-07-29 | Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182046A (en) * | 2013-03-22 | 2013-07-03 | 陈欣 | Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof |
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN108245601A (en) * | 2018-02-28 | 2018-07-06 | 广东力罗定制药有限公司 | A kind of expelling phlegm and arresting coughing capsule and preparation method thereof |
| CN111494523A (en) * | 2020-06-18 | 2020-08-07 | 长春中医药大学 | A quality control method of Chinese medicinal composition with expectorant and antitussive effects |
| CN111759943A (en) * | 2020-07-27 | 2020-10-13 | 重庆师范大学 | A Chinese medicinal composition for health protection, and its preparation method |
-
2005
- 2005-07-29 CN CN 200510031944 patent/CN1726984A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182046A (en) * | 2013-03-22 | 2013-07-03 | 陈欣 | Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof |
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN104147080B (en) * | 2013-05-14 | 2018-04-27 | 肇庆星湖制药有限公司 | Chinese medicine preparation, preparation method and applications |
| CN108245601A (en) * | 2018-02-28 | 2018-07-06 | 广东力罗定制药有限公司 | A kind of expelling phlegm and arresting coughing capsule and preparation method thereof |
| CN111494523A (en) * | 2020-06-18 | 2020-08-07 | 长春中医药大学 | A quality control method of Chinese medicinal composition with expectorant and antitussive effects |
| CN111759943A (en) * | 2020-07-27 | 2020-10-13 | 重庆师范大学 | A Chinese medicinal composition for health protection, and its preparation method |
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