CN1562239A - Lingdancao dispersion tablet and preparation method - Google Patents
Lingdancao dispersion tablet and preparation method Download PDFInfo
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- CN1562239A CN1562239A CN 200410023040 CN200410023040A CN1562239A CN 1562239 A CN1562239 A CN 1562239A CN 200410023040 CN200410023040 CN 200410023040 CN 200410023040 A CN200410023040 A CN 200410023040A CN 1562239 A CN1562239 A CN 1562239A
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- lingdancao
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Abstract
A dispersing tablet is prepared from the Chinese-medicinal herb 'Lingdan herb' and auxiliaries. Its preparing process is also disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicinal tablet and process for making thereof, relate in particular to LINGDANCAO dispersible tablet and preparation method thereof.
Background technology:
Dispersible tablet, changes dosage form and manages as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The original capsule of LINGDANCAO, tablets and other formulations, and all list the national drug ministry standard in.
The technology features of original capsule, tablet is that the medical material in the prescription is carried volatile oil, and after the extraction, filtrate is condensed into extractum, will extract dry, pulverize the back and add suitable adjuvant, and direct encapsulating capsule, or granulate, be pressed into tablet after the drying, and coating.
Tablet, capsule have prolonged disintegration, influence shortcomings such as medicine plays a role rapidly.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly can decompose LINGDANCAO tablet with stripping and preparation method thereof rapidly, overcome the above-mentioned defective of present technology, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
Technical solution of the present invention is a kind of LINGDANCAO dispersible tablet, main constituent is the Chinese medicine LINGDANCAO, it is characterized in that it is the dispersible tablet that contains appropriate amount of auxiliary materials, adjuvant is: one or more various combination in lactose, mannitol, xylitol, calcium sulfate, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, sodium carboxymethyl cellulose, 30 POVIDONE K 30 BP/USP 30, the micropowder silica gel.
The preparation method of LINGDANCAO dispersible tablet is:
(1) get the LINGDANCAO medical material and clean, decontamination is collected volatile oil with steam distillation, and the aqueous solution after the distillation filters, medicinal residues decoct with water secondary, each 1 hour, filter, aqueous solution after filtrate and the above-mentioned distillation merges, and the concentrating under reduced pressure after drying becomes dried cream, is ground into dried cream powder;
(2) adding adjuvant granulates;
A, granulation adjuvant are: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose;
B, granulation binders are: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution;
Mix homogeneously, granulation, drying;
(3) by (2) prepared granular medicine, add the tabletting adjuvant, mix homogeneously, spray into volatile oil, tabletting, the tabletting adjuvant is: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the low-substituted hydroxypropyl cellulose, or outer coatings again behind the tabletting, coating material is the film-coat pre-mixing agent.
The specific embodiment:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of LINGDANCAO dispersible tablet, its main component are LINGDANCAO, and the LINGDANCAO dispersible tablet is the dispersible tablet made from it and appropriate amount of auxiliary materials.Adjuvant is that tablet speed is collapsed and figuration, the conventional tablet that LINGDANCAO dispersible tablet and LINGDANCAO are made, and capsule is compared, its feature is that oral back can rapid disintegrate become homodisperse fine particle in water in three minutes, help the dissolving and the absorption of LINGDANCAO medicine, LINGDANCAO conventional tablet, capsule then disintegrate are slow.
The adjuvant of making the LINGDANCAO dispersible tablet is:
The added adjuvant of granulating: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose.Optimum amount is 10% microcrystalline Cellulose, 5% low-substituted hydroxypropyl cellulose, 5% polyvinylpolypyrrolidone, 2% carboxymethyl starch sodium.
Granulation binders is: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution, optium concentration are 5% 30 POVIDONE K 30 BP/USP 30 alcoholic solution.
Used adjuvant of tabletting and consumption are: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the hydroxypropyl cellulose, optimum amount are 1% micropowder silica gel, 2% carboxymethyl starch sodium or 3% low-substituted hydroxypropyl cellulose.
LINGDANCAO dispersible tablet preparation technology method is:
Process one, get the LINGDANCAO medical material and clean, decontamination is collected volatile oil with steam distillation, aqueous solution after the distillation filters, and medicinal residues decoct with water secondary, each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, behind the concentrating under reduced pressure, filtrate is condensed into thick paste, adds the right amount of auxiliary materials mixing, granulate, drying adds the appropriate amount of auxiliary materials mixing, sprays into volatile oil, tabletting, coating, promptly.
Process two, get LINGDANCAO and clean, remove impurity, pulverize, passed examination is standby; Collect volatile oil with steam distillation, the aqueous solution after the distillation filters, and medicinal residues decoct with water secondary, each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, be evaporated to the extractum of relative density 1.05-1.15 (50 ℃), spray drying, it is standby to collect extract powder; Extract powder is added the right amount of auxiliary materials mixing, granulate, drying adds the appropriate amount of auxiliary materials mixing, sprays into volatile oil, tabletting, coating, promptly.
Process three, get LINGDANCAO and clean, remove impurity, pulverize, passed examination is standby; Collect volatile oil with steam distillation, the aqueous solution after the distillation filters, and medicinal residues decoct with water secondary, each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, be evaporated to the extractum of relative density 1.05-1.15 (50 ℃), vacuum drying becomes dry extract, and dry extract is broken into 80-160 purpose fine powder, add the right amount of auxiliary materials mixing, granulate drying, add the appropriate amount of auxiliary materials mixing, spray into volatile oil, tabletting, coating, promptly.
Process four, get LINGDANCAO and clean, remove impurity, pulverize, passed examination is standby; Collect volatile oil with steam distillation, the aqueous solution after the distillation filters, and medicinal residues decoct with water secondary, each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, concentrating under reduced pressure becomes thick paste, is dried to dry extract, and dry extract is broken into 80-160 purpose fine powder, add the right amount of auxiliary materials mixing, granulate drying, add the appropriate amount of auxiliary materials mixing, spray into volatile oil, tabletting, coating, promptly.
By technology one, two, three, four prepared tablets is non-film-coat or Film coated tablets, and its film-coat material is the film-coat pre-mixing agent.
Most preferred embodiment of the present invention: get LINGDANCAO 1667g and clean, remove impurity, pulverize, passed examination is standby; Collect volatile oil with steam distillation, the aqueous solution after the distillation filters, and medicinal residues decoct with water secondary, each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, spray drying behind the concentrating under reduced pressure is broken into 80-200 order fine powder with dry extract, and extract powder adds the right amount of auxiliary materials mixing, granulate, drying adds the appropriate amount of auxiliary materials mixing, spray into volatile oil, tabletting, coating make 1000 of LINGDANCAO dispersible tablets, every heavy 0.3g.
Advantage of the present invention is:
The oral back of LINGDANCAO dispersible tablet in water in three minutes disintegrate promptly become homodisperse fine particle, help stripping, the absorption of medicine.Common tablet, capsule be disintegrate in 30 minutes then, so the LINGDANCAO dispersible tablet has conventional tablet, incomparable disintegrate and the dissolving out capability of capsule, and it is fast to take post-absorption, the bioavailability advantages of higher.
Claims (3)
1, a kind of LINGDANCAO dispersible tablet, main constituent is the Chinese medicine LINGDANCAO, it is characterized in that it is the dispersible tablet that contains appropriate amount of auxiliary materials, adjuvant is: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, sodium carboxymethyl cellulose, 30 POVIDONE K 30 BP/USP 30, the micropowder silica gel.
2, a kind of preparation method of LINGDANCAO dispersible tablet is characterized in that:
(1) get the LINGDANCAO medical material and clean, decontamination is collected volatile oil with steam distillation, and the aqueous solution after the distillation filters, medicinal residues decoct with water secondary, and each 1 hour, filter, the aqueous solution after filtrate and the above-mentioned distillation merges, behind the concentrating under reduced pressure, be dried to dried cream, be ground into dried cream powder;
(2) adding adjuvant granulates;
A, granulation adjuvant are: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose;
B, granulation binders are: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution;
Mix homogeneously, granulation, drying;
(3) by (2) prepared granular medicine, spray into volatile oil, add the tabletting adjuvant, mix homogeneously, tabletting, the tabletting adjuvant is: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the low-substituted hydroxypropyl cellulose, or outer coatings again behind the tabletting, coating material is the film-coat pre-mixing agent.
3, the preparation method of LINGDANCAO dispersible tablet according to claim 2 is characterized in that the consumption of its adjuvant is:
The percentage by weight of a, granulation adjuvant and consumption thereof is: optimum amount is 10% microcrystalline Cellulose, 5% low-substituted hydroxypropyl cellulose, 5% polyvinylpolypyrrolidone, 2% carboxymethyl starch sodium;
B, granulation binders and consumption thereof are: optium concentration is 5% 30 POVIDONE K 30 BP/USP 30 alcoholic solution;
C, tabletting adjuvant and consumption thereof are: optimum amount is 1% micropowder silica gel, 2% carboxymethyl starch sodium or 3% low-substituted hydroxypropyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023040 CN1562239A (en) | 2004-03-30 | 2004-03-30 | Lingdancao dispersion tablet and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023040 CN1562239A (en) | 2004-03-30 | 2004-03-30 | Lingdancao dispersion tablet and preparation method |
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| Publication Number | Publication Date |
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| CN1562239A true CN1562239A (en) | 2005-01-12 |
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| CN 200410023040 Pending CN1562239A (en) | 2004-03-30 | 2004-03-30 | Lingdancao dispersion tablet and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100413495C (en) * | 2006-09-26 | 2008-08-27 | 赵昱 | Medical use of 2 alpha, 3 beta-dihydroxy-5, 11(13)- diallyl eudesmane-12 acid for inhibiting hepatitis B virus |
| CN100544707C (en) * | 2005-12-14 | 2009-09-30 | 王殿华 | panacea grass soft capsule and production method thereof |
| CN103381191A (en) * | 2013-08-02 | 2013-11-06 | 温先敏 | Sugar-free laggera herba mixture and preparation method thereof |
| CN103751244A (en) * | 2014-02-10 | 2014-04-30 | 青岛蔚蓝生物股份有限公司 | Traditional Chinese medicine oral liquid for treating infectious coryza and preparation method of traditional Chinese medicine oral liquid |
-
2004
- 2004-03-30 CN CN 200410023040 patent/CN1562239A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100544707C (en) * | 2005-12-14 | 2009-09-30 | 王殿华 | panacea grass soft capsule and production method thereof |
| CN100413495C (en) * | 2006-09-26 | 2008-08-27 | 赵昱 | Medical use of 2 alpha, 3 beta-dihydroxy-5, 11(13)- diallyl eudesmane-12 acid for inhibiting hepatitis B virus |
| CN103381191A (en) * | 2013-08-02 | 2013-11-06 | 温先敏 | Sugar-free laggera herba mixture and preparation method thereof |
| CN103751244A (en) * | 2014-02-10 | 2014-04-30 | 青岛蔚蓝生物股份有限公司 | Traditional Chinese medicine oral liquid for treating infectious coryza and preparation method of traditional Chinese medicine oral liquid |
| CN103751244B (en) * | 2014-02-10 | 2016-04-20 | 青岛蔚蓝生物股份有限公司 | A kind of Chinese medicine oral liquid for the treatment of infectious coryza of chicken and preparation method thereof |
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