CN1583051A - Dispersal tablets of thesium Chinese and their preparation - Google Patents
Dispersal tablets of thesium Chinese and their preparation Download PDFInfo
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- CN1583051A CN1583051A CN 200410023041 CN200410023041A CN1583051A CN 1583051 A CN1583051 A CN 1583051A CN 200410023041 CN200410023041 CN 200410023041 CN 200410023041 A CN200410023041 A CN 200410023041A CN 1583051 A CN1583051 A CN 1583051A
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Abstract
A dispersing tablet is prepared from bastardtoadflax herb through washing, pulverizing, decocting, filtering, concentrating, drying, adding auxiliary and adhsive, granulating, drying, tabletting and coating. Said auxiliary is also disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicinal tablet and process for making thereof, relate in particular to BAIRUI FENSANPIAN and preparation method thereof.
Background technology:
Dispersible tablet, changes dosage form and manages as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The original capsule of hundred stamens, tablets and other formulations, and all list the national drug ministry standard in.
The technology features of existing capsule, tablet is that filtrate is condensed into extractum with after the medicinal material extract in the prescription, will extract dry, pulverize the back and add suitable adjuvant, and direct encapsulating capsule, or granulate, be pressed into tablet after the drying, and coating.
Tablet, capsule have prolonged disintegration, influence shortcomings such as medicine plays a role rapidly.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly can decompose BAIRUI PIAN agent with stripping and preparation method thereof rapidly, overcome the above-mentioned defective of present technology, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
Technical solution of the present invention is a kind of BAIRUI FENSANPIAN, and main constituent is Chinese medicine hundred stamens, it is characterized in that it is the dispersible tablet that contains appropriate amount of auxiliary materials; Adjuvant is: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, sodium carboxymethyl cellulose, 30 POVIDONE K 30 BP/USP 30, the micropowder silica gel.
A kind of preparation method of BAIRUI FENSANPIAN is characterized in that:
(1) get hundred stamen medical materials and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃), thick paste is dried to dried cream;
(2) add the granulation adjuvant, and add granulation binders, mix homogeneously, granulation, drying;
A, granulation adjuvant are: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose;
B, granulation binders are: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution;
(3) by (2) prepared granular medicine, add the tabletting adjuvant again, mix homogeneously, tabletting, or outer coatings again behind the tabletting, coating material is the film-coat pre-mixing agent;
The tabletting adjuvant is: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the low-substituted hydroxypropyl cellulose.
The specific embodiment:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of BAIRUI FENSANPIAN, its main component are hundred stamens, and BAIRUI FENSANPIAN is the dispersible tablet made from it and appropriate amount of auxiliary materials.Adjuvant is that tablet speed is collapsed and figuration, BAIRUI FENSANPIAN is compared with conventional tablet and capsule that hundred stamens are made, its feature is that oral back can rapid disintegrate become homodisperse fine particle in water in three minutes, help the dissolving and the absorption of hundred stamen medicines, hundred stamen conventional tablets and capsule then need could slowly disintegrate in 30 minutes.
The adjuvant of making BAIRUI FENSANPIAN is:
The added adjuvant of granulating: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose.Optimum amount is 10% microcrystalline Cellulose, 5% low-substituted hydroxypropyl cellulose, 5% polyvinylpolypyrrolidone, 2%
Carboxymethyl starch sodium.
Granulation binders is: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution, optium concentration are 5% 30 POVIDONE K 30 BP/USP 30 alcoholic solution.
Used adjuvant of tabletting and consumption are: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the low-substituted hydroxypropyl cellulose, optimum amount are 1% micropowder silica gel, 2% carboxymethyl starch sodium or 3% low-substituted hydroxypropyl cellulose.
BAIRUI FENSANPIAN preparation technology's method is:
Process one, get the Herba Thesii medical material and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃), adds the right amount of auxiliary materials mixing, granulates, drying adds the appropriate amount of auxiliary materials mixing, tabletting, coating, promptly.
Process two, get the Herba Thesii medical material and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the extractum of 1.05-1.15 (50 ℃), spray drying, it is standby to collect extract powder; Extract powder is added the right amount of auxiliary materials mixing, granulate, drying adds the appropriate amount of auxiliary materials mixing, tabletting, coating, promptly.
Process three, get the Herba Thesii medical material and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, and being evaporated to relative density is the extractum of 1.05-1.15 (50 ℃), vacuum drying becomes dry extract, dry extract is broken into the fine powder of 80-160, adds the right amount of auxiliary materials mixing, granulates, dry, add the appropriate amount of auxiliary materials mixing, tabletting, coating, promptly.
Process four, get the Herba Thesii medical material and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, and being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃), be dried to dry extract, dry extract is broken into the fine powder of 80-160, adds the right amount of auxiliary materials mixing, granulates, dry, add the appropriate amount of auxiliary materials mixing, tabletting, coating, promptly.
By technology one, two, three, four prepared tablets is plain sheet or Film coated tablets, and its film-coat material is the film-coat pre-mixing agent.
The most preferred embodiment of this invention: get Herba Thesii, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75%7 alcohol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃); Dry below 80 ℃; Dry extract is broken into 80-200 order fine powder, and extract powder adds the right amount of auxiliary materials mixing, granulates, and drying adds the appropriate amount of auxiliary materials mixing, and tabletting, coating make 1000 of BAIRUI FENSANPIAN.
Advantage of the present invention is:
The oral back of BAIRUI FENSANPIAN in water in three minutes disintegrate promptly become homodisperse fine particle, help stripping, the absorption of medicine.Common tablet then, then disintegrate in 30 minutes of capsule, so BAIRUI FENSANPIAN has conventional tablet, incomparable disintegrate and the dissolving out capability of capsule, it is fast to take post-absorption, the bioavailability advantages of higher.
Claims (3)
1, a kind of BAIRUI FENSANPIAN, main constituent is the Chinese medicine Herba Thesii, it is characterized in that it is the dispersible tablet that contains appropriate amount of auxiliary materials, adjuvant is: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, sodium carboxymethyl cellulose, 30 POVIDONE K 30 BP/USP 30, the micropowder silica gel.
2, a kind of preparation method of BAIRUI FENSANPIAN is characterized in that:
(1) get hundred stamen medical materials and clean, decontamination decocts with water after the pulverizing 2 times; Merge 2 times decoction liquor, filter the back merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, stir evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃), thick paste is dried to dried cream;
(2) add the granulation adjuvant, and add granulation binders, mix homogeneously, granulation, drying;
A, granulation adjuvant are: one or more various combination in lactose, calcium sulfate, mannitol, xylitol, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the sodium carboxymethyl cellulose;
B, granulation binders are: the ethanol of 30 POVIDONE K 30 BP/USP 30 and aqueous solution;
(3) by (2) prepared granular medicine, add the tabletting adjuvant again, mix homogeneously, tabletting, or outer coatings again behind the tabletting, coating material is the film-coat pre-mixing agent;
The tabletting adjuvant is: one or more various combination in micropowder silica gel, carboxymethyl starch sodium, the low-substituted hydroxypropyl cellulose.
3, BAIRUI FENSANPIAN according to claim 2 is characterized in that the consumption of its adjuvant is:
The percentage by weight of a, granulation adjuvant and consumption thereof is: optimum amount is 10% microcrystalline Cellulose, 5% low-substituted hydroxypropyl cellulose, 5% polyvinylpolypyrrolidone, 2% carboxymethyl starch sodium;
B, granulation binders and consumption thereof are: optium concentration is 5% 30 POVIDONE K 30 BP/USP 30 alcoholic solution;
C, tabletting adjuvant and consumption thereof are: optimum amount is 1% micropowder silica gel, 2% carboxymethyl starch sodium or 3% low-substituted hydroxypropyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023041 CN1583051A (en) | 2004-03-30 | 2004-03-30 | Dispersal tablets of thesium Chinese and their preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023041 CN1583051A (en) | 2004-03-30 | 2004-03-30 | Dispersal tablets of thesium Chinese and their preparation |
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| CN1583051A true CN1583051A (en) | 2005-02-23 |
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| CN 200410023041 Pending CN1583051A (en) | 2004-03-30 | 2004-03-30 | Dispersal tablets of thesium Chinese and their preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112691129A (en) * | 2021-02-08 | 2021-04-23 | 安徽九华华源药业有限公司 | Granular preparation of bastardtoad herb and its preparation method |
| CN113813391A (en) * | 2021-09-28 | 2021-12-21 | 上海雷允上药业有限公司 | Auxiliary material, application of auxiliary material composition, core of thesium Chinese tablets, film-coated thesium Chinese tablets and preparation method of film-coated thesium Chinese tablets |
| CN115381878A (en) * | 2021-05-25 | 2022-11-25 | 新疆银朵兰药业股份有限公司 | Preparation method of medicine for treating leucoderma, prepared medicine and application thereof |
-
2004
- 2004-03-30 CN CN 200410023041 patent/CN1583051A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112691129A (en) * | 2021-02-08 | 2021-04-23 | 安徽九华华源药业有限公司 | Granular preparation of bastardtoad herb and its preparation method |
| CN115381878A (en) * | 2021-05-25 | 2022-11-25 | 新疆银朵兰药业股份有限公司 | Preparation method of medicine for treating leucoderma, prepared medicine and application thereof |
| CN113813391A (en) * | 2021-09-28 | 2021-12-21 | 上海雷允上药业有限公司 | Auxiliary material, application of auxiliary material composition, core of thesium Chinese tablets, film-coated thesium Chinese tablets and preparation method of film-coated thesium Chinese tablets |
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