CN111759943A - A Chinese medicinal composition for health protection, and its preparation method - Google Patents
A Chinese medicinal composition for health protection, and its preparation method Download PDFInfo
- Publication number
- CN111759943A CN111759943A CN202010734210.9A CN202010734210A CN111759943A CN 111759943 A CN111759943 A CN 111759943A CN 202010734210 A CN202010734210 A CN 202010734210A CN 111759943 A CN111759943 A CN 111759943A
- Authority
- CN
- China
- Prior art keywords
- extract
- rhizoma polygonati
- pseudo
- drying
- heating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention belongs to the technical field of medicine preparation, and discloses a traditional Chinese medicine composite health product and a preparation process thereof, wherein the preparation process of the traditional Chinese medicine composite health product comprises the following steps: adding cold water into pulverized Notoginseng radix, and heating; performing dynamic circulation extraction with ethanol, recovering ethanol, concentrating, and drying to obtain Notoginseng radix extract; adding cold water into pulverized rhizoma Polygonati, heating, filtering, adding water, heating, mixing filtrates, concentrating, and drying to obtain rhizoma Polygonati extract; soaking radix Angelicae sinensis, radix Adenophorae, fructus Schisandrae chinensis, fructus Lycii, and semen Allii Tuberosi, heating, concentrating, adding radix Notoginseng extract, rhizoma Polygonati extract, and starch drying agent, and stirring; drying under reduced pressure, sieving, and making into tablet. The health care product provided by the invention can regulate blood fat, improve blood circulation, regulate immunity, and realize antioxidation, immunoregulation and fatigue resistance. The preparation method of the traditional Chinese medicine composite health product provided by the invention is simple, and can fully realize the retention and exertion of the effects of the medicinal materials and realize the health-care effect.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a traditional Chinese medicine composite health product and a preparation process thereof.
Background
At present, along with improvement and improvement of the material and cultural life of people, people pay more and more attention to body health, but at present, the pace of social life is faster and faster, and unreasonable diet, insufficient sleep and abnormal work and rest become common phenomena. The excessive tension, the too big pressure, the lack of the modern movement, the long bad mood and the like all lead to the increasing of people in sub-health, the decline of the body immunity, the easy fatigue, the easy illness and the influence on the daily life. Immunity refers to the ability of the human immune system to fight infection by pathogens. The immune system consists of thymus, spleen and lymphoid tissue. One of the main functions of the healthy human immune system is the defense function of the body, i.e. protecting the body from damage, helping the body to destroy foreign bacteria and viruses and preventing diseases. The health care products sold in the market at present are various in types, but cannot bring real health care efficacy, and even cause harm to the health of users.
Through the above analysis, the problems and defects of the prior art are as follows: the health care products sold in the market at present are various in types, but cannot bring real health care efficacy, and even cause harm to the health of users.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine composite health product and a preparation process thereof.
The invention is realized in such a way that the preparation process of the traditional Chinese medicine composite health-care product comprises the following steps:
firstly, picking and cleaning dry roots of pseudo-ginseng, drying and then placing the pseudo-ginseng in a grinder to be ground into particles with the particle size of 2-3 mm; adding cold water and citric acid into the pseudo-ginseng particles, heating to 60-70 ℃, and leaching for 3-5 h.
And step two, after filtering, respectively collecting filter residues and filtrate, adding water and citric acid into the filter residues again, heating and leaching, filtering to obtain filtrate, and combining the secondary filtrate to obtain the pseudo-ginseng extracting solution.
And step three, adsorbing the pseudo-ginseng extract obtained in the step two by using resin, then performing dynamic cycle elution by using ethanol, heating and concentrating at the temperature of 60-70 ℃, and recovering the ethanol to obtain a concentrated solution.
Step four, adding ethyl acetate with the volume 3-5 times of that of the concentrated solution into the concentrated solution obtained in the step three, extracting, and collecting an organic layer and a water layer respectively; adding ethyl acetate into the water layer again for extraction, and collecting an organic layer; the two collected organic layers were then combined to give an extract.
Step five, concentrating and drying the extract liquid obtained in the step four to obtain a pseudo-ginseng crude extract; adding water into the pseudo-ginseng crude extract, heating for dissolving, cooling for 36-48 h at 4-6 ℃, and crystallizing to obtain crystals; and under the condition of gas protection, drying and crushing the crystals, and then sieving the crystals with a 50-80-mesh sieve to obtain fine powder, namely the pseudo-ginseng extract.
Step six, rhizoma polygonati pretreatment: cleaning rhizoma polygonati, removing dust and granular impurities on the surface, cutting into thin slices with the thickness of 0.2-1 mm, and drying at a low temperature of 45-60 ℃.
Step seven, crushing the pretreated rhizoma polygonati slices into particles with the particle size of 2-3mm, adding 75-85% ethanol solution which is 15-30 times of the weight of the rhizoma polygonati particles into the rhizoma polygonati particles, carrying out ultrasonic extraction at 50-65 ℃ for 3-5 times for 0.5-2.5 h each time, combining the ethanol extract, and filtering to obtain rhizoma polygonati filtrate I and rhizoma polygonati filter residues.
Step eight, adding cold water into the sealwort filter residue, heating for 2 hours, and filtering to obtain a filtrate II; adding cold water into the filter residue, heating for 2h, filtering to obtain filtrate III, mixing filtrate I, filtrate II and filtrate III, concentrating, and spin-drying with rotary evaporator to obtain crude rhizoma Polygonati extract.
Step nine, diluting the crude polygonatum sibiricum extract obtained in the step eight with a proper amount of distilled water, adding the diluted solution into prepared adsorption resin for adsorption, eluting with distilled water, then eluting with 70-85% ethanol until no extract flows out of the eluate, namely complete elution, collecting ethanol eluate, spin-drying with a rotary evaporator, and drying with a reduced pressure dryer until the weight is constant to obtain a purified polygonatum sibiricum extract.
Step ten, soaking the angelica sinensis, the adenophora stricta, the schisandra chinensis, the medlar and the semen allii tuberosi for 12-15 hours, adding cold water to submerge the medicinal materials, heating for 4-5 hours, filtering to obtain filtrate and filter residues, and keeping the filtrate for later use.
Step eleven, adding cold water into the filter residue obtained in the step eleven to immerse the filter residue, heating for 2-5 hours, and taking a filtrate; and combining the filtrates obtained by the two times of decoction, standing for 20-30 min, and removing bottom precipitates to obtain a liquid medicine.
And step twelve, putting the liquid medicine into a concentration pot for heating and concentrating, transferring the concentrated liquid medicine into a stirrer, sequentially adding the pseudo-ginseng extract, the rhizoma polygonati extract and the starch drying agent, and uniformly stirring to obtain a viscous substance.
And step thirteen, putting the viscous substance obtained in the step twelfth into a constant-temperature reduced-pressure drying box, vacuumizing, drying under reduced pressure, crushing, and sieving with a 80-100-mesh sieve to obtain medicinal powder.
Step fourteen, adding the wetting agent and the anti-sticking agent into the medicinal powder obtained in the step thirteen, mixing and stirring uniformly, placing the mixture into a mould, and pressing the mixture into tablets to obtain the traditional Chinese medicine composite health-care product.
Further, in the step one, the amount of the cold water added is 2-2.5 times of the weight of the pseudo-ginseng particles, and the amount of the citric acid is 2-3% of the mass of the added water.
Further, in the third step, the resin is AB-8, LX-8 or HPD826 resin.
Further, in the third step, the amount of ethanol added during dynamic circulation elution and concentration is 3-4 times of the mass of the pseudo-ginseng particles, the concentration of the ethanol is 65%, and the dynamic circulation extraction time is 20-24 hours.
Further, in the fifth step, the main component of the panax notoginseng extract is panaxtriol saponins.
Further, in the ninth step, the rhizoma polygonati extract mainly contains rhizoma polygonati polysaccharide.
Further, in the twelfth step, the water content of the concentrated liquid medicine is 20% -30%.
Further, in a fourteenth step, the wetting agent is docusate sodium or honey.
Further, in a fourteenth step, the antisticking agent is a composition of one or more of talc, glyceryl monostearate and magnesium stearate.
The invention also aims to provide the traditional Chinese medicine composite health-care product prepared by applying the preparation process of the traditional Chinese medicine composite health-care product, and the traditional Chinese medicine composite health-care product comprises 20-25 parts of pseudo-ginseng, 18-20 parts of rhizoma polygonati, 10-12 parts of angelica sinensis, 10-12 parts of adenophora stricta, 3-6 parts of schisandra chinensis, 4-6 parts of medlar and 1-2 parts of semen allii tuberosi by mass.
By combining all the technical schemes, the invention has the advantages and positive effects that: notoginseng radix is dried root of Notoginseng radix of Araliaceae family, has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain, and can be used for treating hemorrhage, traumatic injury, and swelling and pain due to blood stasis; rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; it is commonly used for deficiency of spleen-stomach qi, tiredness, debilitation, stomach yin deficiency, dry mouth, poor appetite, lung deficiency, dry cough, hemoptysis, essence and blood deficiency, soreness and weakness of waist and knees, early white beard and hair, internal heat, and diabetes; the invention extracts the triol saponin in the panax notoginseng and the rhizoma polygonati and the polysaccharide, can regulate blood fat, improve blood circulation, regulate immunity, prevent tumors, and realize antioxidation, immunoregulation, fatigue resistance, antivirus, bacteriostasis and anti-inflammation.
The radix Angelicae sinensis is dried root of Angelica sinensis (oliv.) Diels of Umbelliferae, and has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation; it is commonly used for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness and constipation. The radix adenophorae has the effects of nourishing yin, clearing heat, moistening lung, reducing phlegm, benefiting stomach and promoting fluid production; it is commonly used for chronic cough due to yin deficiency, tuberculosis cough with phlegm and blood, dry cough with little phlegm, deficiency heat and throat impediment, thirst due to body fluid consumption; the schisandra chinensis has the effects of astringing, arresting discharge, tonifying qi, promoting the production of body fluid, tonifying the kidney and calming the heart; it is commonly used for chronic cough, dyspnea of deficiency type, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, internal heat, diabetes, palpitation, insomnia; fructus Lycii has effects in promoting immunity, resisting aging, resisting tumor, scavenging free radicals, relieving fatigue, resisting radiation, protecting liver, and protecting and improving reproductive function; semen Allii Tuberosi is warm in nature, pungent and sweet in flavor, and enters kidney and liver meridians; warming and nourishing liver and kidney, tonifying yang and arresting spontaneous emission; the product has effects of enhancing liver, spleen and kidney functions, and strengthening yang qi, and the specific component sulfuryl has appetite stimulating effect; semen Allii Tuberosi also has stomach warming effect, and can help human body expel toxin out of body. The Chinese angelica, the adenophora stricta, the schisandra chinensis, the medlar and the semen allii tuberosi are added into the health care medicine, so that the health care medicine can realize the nourishing of a human body, clear away heat and sterilize, tonify qi and promote the production of body fluid, and is helpful for reducing fatigue and improving energy.
The health product provided by the invention is simple in preparation method, and can fully retain and exert the effects of medicinal materials and realize the health care effect of human bodies.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
Fig. 1 is a flow chart of a preparation process of a traditional Chinese medicine composite health product provided by the embodiment of the invention.
FIG. 2 is a graph comparing the mean time to stress response of three groups of mice provided in the examples of the present invention.
FIG. 3 is a graph comparing the average body weight of three groups of mice provided by the example of the present invention.
FIG. 4 is a graph comparing the activity rates of three groups of mice provided by the present invention.
FIG. 5 is a graph comparing the mean blood glucose of three groups of mice provided by the example of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine composite health product and a preparation process thereof, and the invention is described in detail with reference to the accompanying drawings.
As shown in fig. 1, the preparation process of the traditional Chinese medicine composite health product provided by the embodiment of the invention comprises the following steps:
s101, picking and cleaning dry roots of the pseudo-ginseng, and extracting the pseudo-ginseng in a secondary leaching mode by taking citric acid as a protective agent to obtain a pseudo-ginseng extract.
S102, pretreating rhizoma polygonati, and adding an ethanol solution for ultrasonic extraction; and (4) after elution, spin-drying by using a rotary evaporator to obtain a purified polygonatum sibiricum extract.
S103, soaking the angelica sinensis, the adenophora stricta, the schisandra chinensis, the medlar and the semen allii tuberosi for 12-15 hours, adding cold water to submerge the medicinal materials, heating for 4-5 hours, filtering to obtain filtrate and filter residues, and keeping the filtrate for later use.
S104, adding cold water into the filter residue obtained in the S103 to immerse the filter residue, heating for 2-5 hours, and taking a filtrate; and combining the filtrates obtained by the two times of decoction, standing for 20-30 min, and removing bottom precipitates to obtain a liquid medicine.
S105, putting the liquid medicine into a concentration pot for heating and concentrating, transferring the concentrated liquid medicine into a stirrer, sequentially adding the pseudo-ginseng extract, the sealwort extract and the starch drying agent, and uniformly stirring to obtain a viscous substance.
And S106, putting the viscous substance obtained in the step S105 into a constant-temperature reduced-pressure drying box, vacuumizing, drying under reduced pressure, crushing, and sieving with a 80-100-mesh sieve to obtain medicinal powder.
And S107, adding the wetting agent and the anti-sticking agent into the medicinal powder obtained in the step S106, uniformly mixing and stirring, placing the mixture into a mold, and pressing the mixture into tablets to obtain the traditional Chinese medicine composite health-care product.
The wetting agent provided by the embodiment of the invention is docusate sodium or honey.
The antisticking agent provided by the embodiment of the invention is a composition of one or more of talcum powder, glyceryl monostearate and magnesium stearate.
The traditional Chinese medicine composite health care product provided by the embodiment of the invention comprises, by mass, 20-25 parts of pseudo-ginseng, 18-20 parts of rhizoma polygonati, 10-12 parts of angelica sinensis, 10-12 parts of adenophora stricta, 3-6 parts of schisandra chinensis, 4-6 parts of medlar and 1-2 parts of semen allii tuberosi.
The preparation method of the pseudo-ginseng extract provided by the embodiment of the invention comprises the following steps:
(1) picking and cleaning dry roots of the pseudo-ginseng, drying and then putting the pseudo-ginseng into a crusher to be crushed into particles with the particle size of 2-3 mm; adding cold water and citric acid into the pseudo-ginseng particles, heating to 60-70 ℃, and leaching for 3-5 h.
(2) Filtering, collecting residue and filtrate, adding water and citric acid into the residue, heating and extracting, filtering to obtain filtrate, and mixing the filtrates to obtain Notoginseng radix extract.
(3) Adsorbing the obtained pseudo-ginseng extract by using resin, then performing dynamic cycle elution by using ethanol, heating and concentrating at the temperature of 60-70 ℃, and recovering the ethanol to obtain a concentrated solution.
(4) Adding ethyl acetate with the volume 3-5 times that of the concentrated solution into the obtained concentrated solution for extraction, and then respectively collecting an organic layer and a water layer; adding ethyl acetate into the water layer again for extraction, and collecting an organic layer; the two collected organic layers were then combined to give an extract.
(5) Concentrating and drying the obtained extract to obtain a pseudo-ginseng crude extract; adding water into the pseudo-ginseng crude extract, heating for dissolving, cooling for 36-48 h at 4-6 ℃, and crystallizing to obtain crystals; and under the condition of gas protection, drying and crushing the crystals, and then sieving the crystals with a 50-80-mesh sieve to obtain fine powder, namely the pseudo-ginseng extract.
The amount of the cold water added is 2-2.5 times of the weight of the pseudo-ginseng particles, and the amount of the citric acid is 2-3% of the mass of the added water.
The resin provided by the embodiment of the invention is AB-8, LX-8 or HPD826 resin.
The amount of ethanol added during dynamic circulation elution and concentration provided by the embodiment of the invention is 3-4 times of the mass of the pseudo-ginseng particles, the concentration of the ethanol is 65%, and the dynamic circulation extraction time is 20-24 h.
The main component of the panax notoginseng extract provided by the embodiment of the invention is panaxtriol saponins.
The preparation method of the polygonatum sibiricum extract provided by the embodiment of the invention comprises the following steps:
(I) preprocessing rhizoma polygonati: cleaning rhizoma polygonati, removing dust and granular impurities on the surface, cutting into thin slices with the thickness of 0.2-1 mm, and drying at a low temperature of 45-60 ℃.
(II) crushing the pretreated rhizoma polygonati slices into particles with the particle size of 2-3mm, adding 75-85% ethanol solution which is 15-30 times of the weight of the rhizoma polygonati particles into the rhizoma polygonati particles, carrying out ultrasonic extraction at 50-65 ℃ for 3-5 times for 0.5-2.5 h each time, combining ethanol extracting solutions, and filtering to obtain rhizoma polygonati filtrate I and rhizoma polygonati filter residues.
(III) adding cold water into the sealwort filter residue, heating for 2 hours, and filtering to obtain a filtrate II; adding cold water into the filter residue, heating for 2h, filtering to obtain filtrate III, mixing filtrate I, filtrate II and filtrate III, concentrating, and spin-drying with rotary evaporator to obtain crude rhizoma Polygonati extract.
(IV) diluting the obtained crude product of the rhizoma polygonati extract with a proper amount of distilled water, adding the diluted crude product of the rhizoma polygonati extract into prepared adsorption resin for adsorption, eluting with distilled water, then eluting with 70-85% ethanol until no extract flows out of the eluent, namely, the eluent is completely eluted, collecting the ethanol eluent, spin-drying with a rotary evaporator, and drying with a reduced-pressure dryer until the weight is constant, thus obtaining the purified rhizoma polygonati extract.
The rhizoma polygonati extract provided by the embodiment of the invention mainly contains rhizoma polygonati polysaccharide.
The water content of the concentrated liquid medicine provided by the embodiment of the invention is 20-30%.
The invention is further described with reference to specific examples.
Example 1
Case one
The insomnia problem of plum, male and 21 years old, which is caused by fatigue and poor energy before one year, can be relieved after 8 days of taking the product, symptoms disappear after 25 days of treatment, and the sleep is normal.
Case two
Zhangqi, male, age 39, smoking and drinking, poor immunity, and susceptibility to diseases for years, and no appetite in the last month due to overwork. The symptoms are relieved after the product is taken for three days, and the symptoms are eliminated after the product is taken for ten days.
Example 2
Picking and cleaning dried root of Notoginseng radix, drying, and pulverizing into 2-3mm granule; adding cold water 2 times the weight of the particles into the pseudo-ginseng particles, heating to 40 ℃, and keeping the temperature for 12 hours; adding ethanol with the mass 3 times of that of the pseudo-ginseng particles and the concentration of 65% for dynamic circulation extraction for 24 hours, recovering the ethanol, and concentrating to obtain an extract; drying the extract to obtain the pseudo-ginseng extract.
Example 3
Cleaning rhizoma Polygonati, drying, pulverizing into 2-3mm granules, adding cold water into rhizoma Polygonati granules, heating for 2 hr, and filtering; adding cold water into the filter residue, heating for 2h, and filtering; and adding cold water into the filter residue again, heating for 2h, filtering, combining the filtrates, concentrating to obtain an extract, and drying the extract to obtain the sealwort extract.
Example 4
4kg of rhizoma polygonati is used for extracting the rhizoma polygonati extract, and the extraction time is used for analyzing the yield of the rhizoma polygonati extract:
example 5
Soaking radix Angelicae sinensis, radix Adenophorae, fructus Schisandrae chinensis, fructus Lycii, and semen Allii Tuberosi for 12h, adding cold water to submerge the materials, heating for 4h, filtering, and keeping the filtrate for use; adding cold water into the filter residue to immerse the filter residue, heating for 2h, and collecting the filtrate; mixing the two decoctions, standing for 20min, and removing bottom precipitate to obtain medicinal liquid; heating and concentrating the medicinal liquid in a concentrating pot, transferring the concentrated medicinal liquid to a stirrer, sequentially adding the Notoginseng radix extract obtained in example 2, the rhizoma Polygonati extract obtained in example 3, and a starch drying agent, and stirring to obtain a viscous substance; placing into a constant-temperature reduced-pressure drying oven, vacuumizing, drying under reduced pressure, pulverizing, and sieving with 80 mesh sieve to obtain medicinal powder; adding Mel and glyceryl monostearate into the medicinal powder, mixing, and placing in a mold to obtain the final product.
Example 6
The health care efficacy of the traditional Chinese medicine composite health care product is researched: setting the sheet-shaped traditional Chinese medicine composite health-care product prepared in the example 5 as an experimental group; the decoction of pseudo-ginseng, rhizoma polygonati, angelica, radix adenophorae, schisandra, medlar and semen allii tuberosi is used as a first control group; the commercially available functionally similar drug is control group two.
Respectively arranging 10 mice in an experimental group, a first control group and a second control group, carrying out normal feeding in the same environment, respectively feeding three medicaments for 20 days continuously, and carrying out the following index determination:
stress reaction
Stress response tests of three groups of mice were carried out on days 1, 10, 15 and 20 of feeding, respectively, and each group was averaged, and the time from stimulation to response was recorded as the stress time, and the average stress response time of three groups of mice was compared with that shown in FIG. 2 (unit: s).
Second, body weight
The body weights of three groups of mice were measured on days 1, 10, 15 and 20 of feeding, respectively, and the body weight changes of the mice were recorded by averaging each group, and FIG. 3 is a graph comparing the average body weights of three groups of mice (unit: g).
Third, the amount of movement
The activity of three groups of mice was measured on days 1, 10, 15 and 20 of the breeding, the average value of each group was taken, the change in the activity of the mice was recorded, and fig. 4 is a graph showing the comparison of the activity rates of three groups of mice (unit:%).
The mice in the second control group showed transient hyperexcitability at 15 days, but the activity decreased significantly at 20 days.
Blood component (blood sugar)
Blood glucose of three groups of mice was measured on days 1, 10, 15 and 20, respectively, before fasting and water deprivation for 3 hours, an average value was taken for each group, and blood glucose changes of the mice were recorded, and FIG. 5 is a comparison graph of average blood glucose (unit: mmol/L) of three groups of mice.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any modification, equivalent replacement, and improvement made by those skilled in the art within the technical scope of the present invention disclosed herein, which is within the spirit and principle of the present invention, should be covered by the present invention.
Claims (10)
1. The preparation process of the traditional Chinese medicine composite health product is characterized by comprising the following steps of:
firstly, picking and cleaning dry roots of pseudo-ginseng, drying and then placing the pseudo-ginseng in a grinder to be ground into particles with the particle size of 2-3 mm; adding cold water and citric acid into the pseudo-ginseng particles, heating to 60-70 ℃, and leaching for 3-5 h;
step two, after filtering, respectively collecting filter residues and filtrate, adding water and citric acid into the filter residues again, heating and leaching, filtering to obtain filtrate, and combining the secondary filtrate to obtain pseudo-ginseng extract;
step three, adsorbing the pseudo-ginseng extract obtained in the step two by using resin, then performing dynamic cycle elution by using ethanol, heating and concentrating at the temperature of 60-70 ℃, and recovering the ethanol to obtain a concentrated solution;
step four, adding ethyl acetate with the volume 3-5 times of that of the concentrated solution into the concentrated solution obtained in the step three, extracting, and collecting an organic layer and a water layer respectively; adding ethyl acetate into the water layer again for extraction, and collecting an organic layer; then combining the organic layers collected twice to obtain extract liquor;
step five, concentrating and drying the extract liquid obtained in the step four to obtain a pseudo-ginseng crude extract; adding water into the pseudo-ginseng crude extract, heating for dissolving, cooling for 36-48 h at 4-6 ℃, and crystallizing to obtain crystals; drying and crushing the crystals under the protection of gas, and sieving the crystals with a 50-80-mesh sieve to obtain fine powder, namely the pseudo-ginseng extract;
step six, rhizoma polygonati pretreatment: cleaning rhizoma polygonati, removing dust and granular impurities on the surface, cutting into thin slices with the thickness of 0.2-1 mm, and drying at a low temperature of 45-60 ℃;
step seven, crushing pretreated rhizoma polygonati slices into particles with the particle size of 2-3mm, adding 75-85% ethanol solution which is 15-30 times of the weight of the rhizoma polygonati particles into the rhizoma polygonati particles, carrying out ultrasonic extraction at 50-65 ℃ for 3-5 times for 0.5-2.5 h each time, combining ethanol extracting solutions, and filtering to obtain rhizoma polygonati filtrate I and rhizoma polygonati filter residues;
step eight, adding cold water into the sealwort filter residue, heating for 2 hours, and filtering to obtain a filtrate II; adding cold water into the filter residue, heating for 2h, filtering to obtain filtrate III, mixing filtrate I, filtrate II and filtrate III, concentrating, and spin-drying with rotary evaporator to obtain crude rhizoma Polygonati extract;
step nine, diluting the crude polygonatum sibiricum extract obtained in the step eight with a proper amount of distilled water, then adding the diluted solution into prepared adsorption resin for adsorption, eluting with distilled water, then eluting with 70-85% ethanol until no extract flows out of the eluate, namely complete elution is obtained, collecting ethanol eluate, spin-drying with a rotary evaporator, and drying with a reduced pressure dryer until the weight is constant to obtain a purified polygonatum sibiricum extract;
step ten, soaking the angelica sinensis, the adenophora stricta, the schisandra chinensis, the medlar and the semen allii tuberosi for 12-15 hours, adding cold water to submerge the medicinal materials, heating for 4-5 hours, filtering to obtain filtrate and filter residues, and keeping the filtrate for later use;
step eleven, adding cold water into the filter residue obtained in the step eleven to immerse the filter residue, heating for 2-5 hours, and taking a filtrate; mixing the two decocted filtrates, standing for 20-30 min, and removing bottom precipitates to obtain a liquid medicine;
step twelve, putting the liquid medicine into a concentration pot for heating and concentrating, transferring the concentrated liquid medicine into a stirrer, sequentially adding the pseudo-ginseng extract, the rhizoma polygonati extract and the starch drying agent, and uniformly stirring to obtain a viscous substance;
thirteen, putting the viscous substance obtained in the twelfth step into a constant-temperature reduced-pressure drying box, vacuumizing and drying under reduced pressure, crushing, and sieving with a 80-100-mesh sieve to obtain medicinal powder;
step fourteen, adding the wetting agent and the anti-sticking agent into the medicinal powder obtained in the step thirteen, mixing and stirring uniformly, placing the mixture into a mould, and pressing the mixture into tablets to obtain the traditional Chinese medicine composite health-care product.
2. The preparation process of the traditional Chinese medicine composite health product according to claim 1, wherein in the first step, the amount of the added cold water is 2-2.5 times of the weight of the pseudo-ginseng particles, and the amount of the citric acid is 2-3% of the mass of the added water.
3. The process for preparing a composite health product of traditional Chinese medicine according to claim 1, wherein in the third step, the resin is AB-8, LX-8 or HPD826 resin.
4. The preparation process of the traditional Chinese medicine composite health product according to claim 1, wherein in the third step, the amount of ethanol added in the dynamic circulation elution and concentration is 3-4 times of the mass of the pseudo-ginseng particles, the concentration of the ethanol is 65%, and the dynamic circulation extraction time is 20-24 hours.
5. The process for preparing a compound health product of traditional Chinese medicine according to claim 1, wherein in step five, the main component of the notoginseng extract is panaxatriol saponin.
6. The process for preparing a traditional Chinese medicine composite health product according to claim 1, wherein in the ninth step, the rhizoma polygonati extract mainly contains rhizoma polygonati polysaccharide.
7. The process for preparing a composite health product of traditional Chinese medicine according to claim 1, wherein in the twelfth step, the water content of the concentrated liquid medicine is 20-30%.
8. The process for preparing a composite health product of traditional Chinese medicine according to claim 1, wherein in the fourteenth step, the wetting agent is docusate sodium or honey.
9. The process for preparing a composite health product according to claim 1, wherein in the fourteenth step, the anti-sticking agent is a combination of one or more of talc, glyceryl monostearate and magnesium stearate.
10. The traditional Chinese medicine compound health product prepared by the preparation process of the traditional Chinese medicine compound health product according to any one of claims 1 to 9 is characterized by comprising, by mass, 20 to 25 parts of pseudo-ginseng, 18 to 20 parts of rhizoma polygonati, 10 to 12 parts of angelica sinensis, 10 to 12 parts of radix adenophorae, 3 to 6 parts of schisandra chinensis, 4 to 6 parts of medlar and 1 to 2 parts of semen allii tuberosi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010734210.9A CN111759943A (en) | 2020-07-27 | 2020-07-27 | A Chinese medicinal composition for health protection, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010734210.9A CN111759943A (en) | 2020-07-27 | 2020-07-27 | A Chinese medicinal composition for health protection, and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111759943A true CN111759943A (en) | 2020-10-13 |
Family
ID=72727505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010734210.9A Pending CN111759943A (en) | 2020-07-27 | 2020-07-27 | A Chinese medicinal composition for health protection, and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111759943A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112062872A (en) * | 2020-10-15 | 2020-12-11 | 扬州市博睿糖生物技术有限公司 | Polygonatum sibiricum homogeneous polysaccharide and preparation method and application thereof |
| CN115868527A (en) * | 2022-12-29 | 2023-03-31 | 西南林业大学 | Novel plant preservative and preparation method and application thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1726984A (en) * | 2005-07-29 | 2006-02-01 | 王衡新 | Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method |
| CN1745656A (en) * | 2004-09-08 | 2006-03-15 | 史钦荣 | Compound Chinese medicinal health-care food |
| CN101293070A (en) * | 2008-06-25 | 2008-10-29 | 河南中医学院 | Extraction of seal wort oligose with effect of reinforcing immune function from seal wort |
| CN102614374A (en) * | 2012-04-12 | 2012-08-01 | 涂传荣 | Chinese medicine tablet with immunoregulation and hypoglycemic effects and preparation method thereof |
| CN103393984A (en) * | 2013-07-22 | 2013-11-20 | 马术奇 | Compound traditional Chinese medicine compound health-care product and preparation process thereof |
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN105998652A (en) * | 2016-06-30 | 2016-10-12 | 冯袖幅 | Traditional Chinese medicine composition and application and preparation thereof |
| CN107693559A (en) * | 2017-11-27 | 2018-02-16 | 贵州浩诚药业有限公司 | The preparation method of Notogineng Extract |
| CN109320624A (en) * | 2018-09-17 | 2019-02-12 | 田金举 | A kind of extraction process of Rhizoma Polygonati extract |
| CN110150429A (en) * | 2019-06-20 | 2019-08-23 | 山东润福宜生物科技有限公司 | Etech tea |
-
2020
- 2020-07-27 CN CN202010734210.9A patent/CN111759943A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1745656A (en) * | 2004-09-08 | 2006-03-15 | 史钦荣 | Compound Chinese medicinal health-care food |
| CN1726984A (en) * | 2005-07-29 | 2006-02-01 | 王衡新 | Chinese materia medica preparation for strengthening the spleen, eliminating dampness, expelling phlegm and relieving a cough, and preparation method |
| CN101293070A (en) * | 2008-06-25 | 2008-10-29 | 河南中医学院 | Extraction of seal wort oligose with effect of reinforcing immune function from seal wort |
| CN102614374A (en) * | 2012-04-12 | 2012-08-01 | 涂传荣 | Chinese medicine tablet with immunoregulation and hypoglycemic effects and preparation method thereof |
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN103393984A (en) * | 2013-07-22 | 2013-11-20 | 马术奇 | Compound traditional Chinese medicine compound health-care product and preparation process thereof |
| CN105998652A (en) * | 2016-06-30 | 2016-10-12 | 冯袖幅 | Traditional Chinese medicine composition and application and preparation thereof |
| CN107693559A (en) * | 2017-11-27 | 2018-02-16 | 贵州浩诚药业有限公司 | The preparation method of Notogineng Extract |
| CN109320624A (en) * | 2018-09-17 | 2019-02-12 | 田金举 | A kind of extraction process of Rhizoma Polygonati extract |
| CN110150429A (en) * | 2019-06-20 | 2019-08-23 | 山东润福宜生物科技有限公司 | Etech tea |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112062872A (en) * | 2020-10-15 | 2020-12-11 | 扬州市博睿糖生物技术有限公司 | Polygonatum sibiricum homogeneous polysaccharide and preparation method and application thereof |
| CN112062872B (en) * | 2020-10-15 | 2023-06-23 | 扬州大学 | Polygonatum sibiricum uniform polysaccharide and preparation method and application thereof |
| CN115868527A (en) * | 2022-12-29 | 2023-03-31 | 西南林业大学 | Novel plant preservative and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102068625B (en) | Traditional Chinese medicinal composition for reducing blood sugar and blood pressure and preparation method thereof | |
| CN101485830B (en) | Pure Chinese medicine anti-aging health-care capsule | |
| CN111759943A (en) | A Chinese medicinal composition for health protection, and its preparation method | |
| CN105918946B (en) | Jujube-wolfberry liver-nourishing composition, granules and preparation method thereof | |
| Jiang et al. | Post-infectious cough of different syndromes treated by traditional Chinese medicines: A review | |
| CN101011562B (en) | Novel formulation of shenqiwendan decoction and production method thereof | |
| CN104800771A (en) | Traditional Chinese medicine preparation for treating children sleep terror disorder and preparation method thereof | |
| CN113842443A (en) | Pharmaceutical composition for treating xerostomia after nasopharyngeal carcinoma radiotherapy | |
| CN110934974A (en) | Traditional Chinese medicine composition for treating lung cancer, traditional Chinese medicine preparation and preparation method thereof | |
| CN107952036B (en) | Traditional Chinese medicine preparation for reducing blood sugar and preparation method thereof | |
| WO2017101154A1 (en) | Stomach-nourishing traditional chinese medicine composition and preparation method therefor | |
| CN105362630A (en) | Climacteric syndrome treatment pharmaceutical composition and preparation method thereof | |
| CN110732015A (en) | A Chinese medicinal composition for treating diabetes due to deficiency of both qi and yin | |
| CN100421706C (en) | Chinese medicinal composition for treating climacteric syndrome and its preparation method | |
| CN105797092B (en) | Yiyuan anti-cold mixture | |
| CN114588228B (en) | Composition for treating type 2 diabetes | |
| CN108853340A (en) | A kind of Chinese medicine of nourishing the liver and kidney and preparation method thereof | |
| CN103690834B (en) | A kind of blood pressure lowering Chinese medicinal composition and preparation method thereof | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN108721425B (en) | Lung-clearing acupoint application paste and preparation method thereof | |
| CN105412673A (en) | Drug for treating Hashimoto disease and preparing method thereof | |
| CN104922301A (en) | Traditional Chinese medicine preparation for gastric mucosa prolapse syndrome and preparation method of traditional Chinese medicine preparation | |
| CN110787245A (en) | Traditional Chinese medicine decoction pieces suitable for recovery period of cancer treatment and radiotherapy and preparation method thereof | |
| CN104940726A (en) | Traditional Chinese medicine preparation for pulmonary alveolar proteinosis and preparation method of traditional Chinese medicine preparation | |
| CN116407606A (en) | Superfine powder for conditioning spontaneous perspiration and night sweat and medicine thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |